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Pesquisa : C10.597.606.150.500.800.100.100 [Categoria DeCS]
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[PMID]:29390458
[Au] Autor:Jang SH; Ha JW; Kim HY; Seo YS
[Ad] Endereço:Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University.
[Ti] Título:Recovery of injured Broca's portion of arcuate fasciculus in the dominant hemisphere in a patient with traumatic brain injury.
[So] Source:Medicine (Baltimore);96(51):e9183, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Recovery of injured AF in patients with traumatic brain injury (TBI) has not been reported. In this study, we report on a patient with TBI who recovered from an injury to Broca's portion of AF in the dominant hemisphere, diagnosed by diffusion tensor tractography (DTT). PATIENT CONCERNS: A 28-year-old right-handed male patient suffered head trauma resulting from sliding while riding a motorcycle. DIAGNOSES: He was diagnosed with a traumatic contusional hemorrhage in the left frontal lobe, subarachnoid hemorrhage, and subdural hemorrhage in the left fronto-temporal lobe. INTERVENTIONS: He underwent craniectomy on the left fronto-temporal area, and hematoma removal for the subdural hemorrhage in the neurosurgery department of a university hospital. Two weeks after the injury, he was transferred to the rehabilitation department of another university hospital. He showed severe aphasia and brain MRI showed leukomalactic lesion in the left frontal lobe. OUTCOMES: The result WAB for the patient showed severe aphasia, with an aphasia quotient of 45.3 percentile. However, his aphasia improved rapidly by 9 months with an aphasia quotient at the 100.0 percentile. 2-week DTT detected discontinuity in the subcortical white matter at the branch to Broca's area of left AF. By contrast, on 9-month DTT, the discontinued portion of left AF was elongated to the left Broca's area. LESSONS: Recovery of injured Broca's portion of AF in the dominant hemisphere along with excellent improvement of aphasia was demonstrated in a patient with TBI. This study has important implications in brain rehabilitation because the mechanism of recovery from aphasia following TBI has not been elucidated.
[Mh] Termos MeSH primário: Afasia de Broca/fisiopatologia
Núcleo Arqueado do Hipotálamo/fisiopatologia
Lesões Encefálicas Traumáticas/diagnóstico
Lesões Encefálicas Traumáticas/reabilitação
Vias Neurais/lesões
[Mh] Termos MeSH secundário: Adulto
Afasia de Broca/etiologia
Lesões Encefálicas Traumáticas/cirurgia
Área de Broca/lesões
Craniotomia/métodos
Imagem de Tensor de Difusão/métodos
Seguimentos
Lobo Frontal/lesões
Lobo Frontal/patologia
Lateralidade Funcional
Hematoma Subdural/diagnóstico
Hematoma Subdural/reabilitação
Hematoma Subdural/cirurgia
Seres Humanos
Escala de Gravidade do Ferimento
Imagem por Ressonância Magnética/métodos
Masculino
Recuperação de Função Fisiológica
Medição de Risco
Lobo Temporal/lesões
Lobo Temporal/patologia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009183


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[PMID]:28596248
[Au] Autor:Saxon JA; Thompson JC; Jones M; Harris JM; Richardson AM; Langheinrich T; Neary D; Mann DM; Snowden JS
[Ad] Endereço:Manchester Academic Health Sciences Centre, Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, UK.
[Ti] Título:Examining the language and behavioural profile in FTD and ALS-FTD.
[So] Source:J Neurol Neurosurg Psychiatry;88(8):675-680, 2017 Aug.
[Is] ISSN:1468-330X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: A proportion of patients with behavioural variant frontotemporal dementia (bvFTD) develop amyotrophic lateral sclerosis (ALS). It is currently unknown whether the behavioural and cognitive syndrome in bvFTD with ALS (ALS-FTD) is indistinguishable from that of bvFTD alone. METHODS: A retrospective cohort of 241 patients with clinical diagnoses of bvFTD (n=185) or ALS-FTD (n=56) was examined with respect to behavioural, cognitive and neuropsychiatric symptoms. Features were rated as present or absent based on information recorded from clinical interviews and detailed neuropsychological assessment. RESULTS: A number of behavioural and affective changes were reported more frequently in bvFTD than ALS-FTD: social disinhibition (p<0.001), inertia (p<0.001), loss of sympathy and empathy (p 0.008), repetitive behaviours (p<0.001) and dietary changes (p<0.001). Warmth of affect demonstrated in the clinic setting was reported more often in ALS-FTD than bvFTD (p<0.001). Executive impairments occurred equally in both groups. Language impairments were more common in ALS-FTD than bvFTD: agrammatism (p<0.017) and impaired sentence comprehension (p<0.036). Psychotic features were relatively rare and did not distinguish the groups. CONCLUSIONS: Our findings suggest differences between bvFTD and ALS-FTD. In particular, while changes in social behaviour are prominent in bvFTD alone, there may be a comparatively greater degree of language impairment in ALS-FTD. Prospective exploration of the pattern of differences between these groups will be essential. Identification of a distinct neuropsychological phenotype in ALS-FTD may have clinical implications for early diagnosis, disease management and care planning and theoretical implications for our understanding of the relationship between ALS and FTD.
[Mh] Termos MeSH primário: Esclerose Amiotrófica Lateral/diagnóstico
Demência Frontotemporal/diagnóstico
Transtornos da Linguagem/diagnóstico
Transtornos do Comportamento Social/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Afasia de Broca/diagnóstico
Transtornos da Percepção Auditiva/diagnóstico
Estudos de Coortes
Diagnóstico Diferencial
Progressão da Doença
Diagnóstico Precoce
Feminino
Seres Humanos
Masculino
Meia-Idade
Transtornos do Humor/diagnóstico
Testes Neuropsicológicos
Estudos Retrospectivos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171114
[Lr] Data última revisão:
171114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE
[do] DOI:10.1136/jnnp-2017-315667


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[PMID]:28537114
[Au] Autor:Steurer J
[Ad] Endereço:1 Horten-Zentrum für praxisorientierte Forschung und Wissenstransfer, Universitätsspital Zürich.
[Ti] Título:Sprach- und Sprechtherapie bei chronischer Aphasie nach Schlaganfall wirksam..
[So] Source:Praxis (Bern 1994);106(11):601-602, 2017.
[Is] ISSN:1661-8157
[Cp] País de publicação:Switzerland
[La] Idioma:ger
[Mh] Termos MeSH primário: Afasia de Broca/terapia
Terapia da Linguagem/métodos
Fonoterapia/métodos
Acidente Vascular Cerebral/complicações
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seguimentos
Seres Humanos
Testes de Linguagem
Masculino
Meia-Idade
Qualidade de Vida
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170525
[St] Status:MEDLINE
[do] DOI:10.1024/1661-8157/a002684


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[PMID]:27590260
[Au] Autor:Chang J; Zhang H; Tan Z; Xiao J; Li S; Gao Y
[Ad] Endereço:Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, No. 5 Haiyuncang, 100700, Beijing, Dongcheng District, China. ear6979@163.com.
[Ti] Título:Effect of electroacupuncture in patients with post-stroke motor aphasia : Neurolinguistic and neuroimaging characteristics.
[So] Source:Wien Klin Wochenschr;129(3-4):102-109, 2017 Feb.
[Is] ISSN:1613-7671
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In this study we investigated the neurolinguistic and neuroimaging characteristics of post-stroke motor aphasia patients. The effects of acupuncture on cortex activation by using magnetic resonance imaging (MRI) in patients with motor aphasia were also studied. METHODS: In this study 43 patients with motor aphasia after stroke were assessed according to Clinical Rehabilitation Research Center aphasia examination (CRRCAE) for linguistic evaluation and MRI and computed tomography (CT) were used for the analyses of brain lesions. The MRI imaging data were also examined using statistical parametric mapping (SPM8) software. Cortex activation images during acupuncture were analyzed using generalized linear model analysis. RESULTS: The results of MRI and CT showed diverse brain lesion regions of post-stroke motor aphasia including the cortex, subcortex and cortex together with the subcortex. The language-related brain areas are activated by acupuncture including frontal, temporal, parietal and occipital lobes as well as insula, precuneus and other wide range of brain function areas as shown by MRI. CONCLUSIONS: Our study showed that the brain lesion regions in post-stroke motor aphasia were not completely consistent with the classical motor speech center. By using MRI our study results suggest that the formation of cognitive language may be involved with the cortical-subcortical functional networks. Acupuncture may be useful for treatment of motor aphasia after stroke.
[Mh] Termos MeSH primário: Afasia de Broca/diagnóstico
Afasia de Broca/reabilitação
Eletroacupuntura/métodos
Neuroimagem/métodos
Reabilitação do Acidente Vascular Cerebral/métodos
Acidente Vascular Cerebral/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Afasia de Broca/etiologia
Feminino
Seres Humanos
Testes de Linguagem
Masculino
Meia-Idade
Acidente Vascular Cerebral/complicações
Resultado do Tratamento
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160904
[St] Status:MEDLINE
[do] DOI:10.1007/s00508-016-1070-1


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[PMID]:27631161
[Au] Autor:Rutar Gorisek V; Zupanc Isoski V; Belic A; Manouilidou C; Koritnik B; Bon J; Pecaric Meglic N; Vrabec M; Zibert J; Repovs G; Zidar J
[Ad] Endereço:Institute of Clinical Neurophysiology, University Medical Centre Ljubljana, Zaloska cesta 7, SI-1525 Ljubljana, Slovenia; Department of Neurology, University Medical Centre Ljubljana, Zaloska cesta 2, SI-1000 Ljubljana, Slovenia. Electronic address: veronika.rutar@kclj.si.
[Ti] Título:Beyond aphasia: Altered EEG connectivity in Broca's patients during working memory task.
[So] Source:Brain Lang;163:10-21, 2016 Dec.
[Is] ISSN:1090-2155
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Broca's region and adjacent cortex presumably take part in working memory (WM) processes. Electrophysiologically, these processes are reflected in synchronized oscillations. We present the first study exploring the effects of a stroke causing Broca's aphasia on these processes and specifically on synchronized functional WM networks. We used high-density EEG and coherence analysis to map WM networks in ten Broca's patients and ten healthy controls during verbal WM task. Our results demonstrate that a stroke resulting in Broca's aphasia also alters two distinct WM networks. These theta and gamma functional networks likely reflect the executive and the phonological processes, respectively. The striking imbalance between task-related theta synchronization and desynchronization in Broca's patients might represent a disrupted balance between task-positive and WM-irrelevant functional networks. There is complete disintegration of left fronto-centroparietal gamma network in Broca's patients, which could reflect the damaged phonological loop.
[Mh] Termos MeSH primário: Afasia de Broca/etiologia
Afasia de Broca/fisiopatologia
Eletroencefalografia
Memória de Curto Prazo
Acidente Vascular Cerebral/complicações
[Mh] Termos MeSH secundário: Idoso
Estudos de Casos e Controles
Córtex Cerebral/fisiopatologia
Fenômenos Eletrofisiológicos
Função Executiva
Feminino
Ritmo Gama
Seres Humanos
Masculino
Meia-Idade
Ritmo Teta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160916
[St] Status:MEDLINE


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[PMID]:27465621
[Au] Autor:Hausmann A; Fischer N; Breitkopf S; Menne F; Jess K; Schmidmayr S; Wendtner CM; Hentrich M
[Ad] Endereço:Klinikum Schwabing, Clinic of Hematology, Oncology, Immunology, Palliative Medicine, Infectious Diseases and Tropical Medicine, Munich.
[Ti] Título:Severe motor aphasia after reinfusion of cryopreserved autologous stem cells after myeloablative conditioning.
[So] Source:Transfusion;56(10):2615-2617, 2016 Oct.
[Is] ISSN:1537-2995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Autologous peripheral blood stem cells (PBSCs) are usually cryopreserved before high-dose chemotherapy (HDCT) and autologous peripheral blood stem cell transplantation (PBSCT). The freezing process requires the addition of cryoprotectants such as dimethyl sulfoxide (DMSO), which is vital for cell viability in frozen aliquots. DMSO has a number of well-described side effects. However, severe neurologic side effects assigned to DMSO are exceedingly rare. CASE REPORT: A 64-year-old female underwent HDCT followed by PBSCT as consolidation therapy in relapsed high-grade (Grade 3B) Stage IIIA follicular lymphoma. PBSCs were mobilized using granulocyte-colony stimulating factor and plerixafor after the second cycle of R-DHAP (rituximab, dexamethasone, high-dose Ara-C, cisplatin) salvage chemotherapy. A total of 7.18 × 10 /kg body weight CD34+ cells were cryopreserved using 10% DMSO. HDCT was administered some weeks later followed by reinfusion of two bags of PBSCs, each containing 98 mL with 1.6 × 10 /kg body weight CD34+ cells. Within a few minutes the patient developed a motor aphasia and became very agitated. Brain imaging did not reveal any pathologic finding. After being transferred to the intensive care unit the patient's condition steadily improved and the motor aphasia resolved completely within 6 hours after its onset. CONCLUSION: This is, to our knowledge, the first report to describe an episode of severe motor aphasia during PBSCT. Given the close timely correlation with PBSCT, this episode appears to be caused by dimethyl sulfoxide (DMSO) and might possibly have been prevented by use of lower concentrations of DMSO.
[Mh] Termos MeSH primário: Afasia de Broca/induzido quimicamente
Criopreservação/métodos
Dimetil Sulfóxido/efeitos adversos
Transplante de Células-Tronco de Sangue Periférico/métodos
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Linfoma Folicular/terapia
Meia-Idade
Agonistas Mieloablativos/uso terapêutico
Condicionamento Pré-Transplante/métodos
Transplante Autólogo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Myeloablative Agonists); YOW8V9698H (Dimethyl Sulfoxide)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170526
[Lr] Data última revisão:
170526
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160729
[St] Status:MEDLINE
[do] DOI:10.1111/trf.13744


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[PMID]:27462834
[Au] Autor:Lorenzen A; Wilke M; Alber M; Milian M; Bornemann A; Ernemann U; Rona S
[Ad] Endereço:Department of Pediatric Neurology and Developmental Medicine, University of Tübingen, Tübingen, Germany.
[Ti] Título:Multimodal Assessment Reveals Late-Onset Hemispheric Shift of Language in a Child with Meningocerebral Dysplasia.
[So] Source:Neuropediatrics;47(5):341-5, 2016 Oct.
[Is] ISSN:1439-1899
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:We report on a girl with progressive left frontal tissue destruction starting at the age of almost 8 years. She manifested acutely with epileptic seizures accompanied by Broca aphasia as well as transient right hemiparesis. Due to refractory epilepsy developing over the next years, which originated from the left frontal lobe, the decision was made to proceed to epilepsy surgery. By then, her language functions had recovered despite progressive left frontal tissue-destruction, raising the possibility of a hemispheric shift of language. Clinical functional magnetic resonance imaging (fMRI) was conducted to localize brain regions involved in language production. A complex pattern of clear right-hemispheric dominance, but with some left-sided contribution was found. However, a Wada test suggested the left hemisphere to be critical, seemingly contradicting fMRI. Invasive electroencephalogram recordings could reconcile these results by identifying the fMRI-detected, residual left-sided activation as being relevant for speech production. Only by combining the localizing information from fMRI with the information obtained by two invasive procedures could the unusual pattern of late-onset language reorganization be uncovered. This allowed for extensive left frontal resection, with histology confirming meningocerebral angiodysplasia. Postoperatively, language functions were preserved and seizure outcome was excellent. The implications of our findings for presurgical assessments in children are discussed.
[Mh] Termos MeSH primário: Angiodisplasia/cirurgia
Afasia de Broca/fisiopatologia
Encefalopatias/cirurgia
Epilepsia do Lobo Frontal/cirurgia
Linguagem
[Mh] Termos MeSH secundário: Angiodisplasia/complicações
Angiodisplasia/patologia
Angiodisplasia/fisiopatologia
Afasia de Broca/etiologia
Encefalopatias/complicações
Encefalopatias/patologia
Encefalopatias/fisiopatologia
Mapeamento Encefálico
Criança
Eletroencefalografia
Epilepsia do Lobo Frontal/etiologia
Epilepsia do Lobo Frontal/fisiopatologia
Feminino
Lateralidade Funcional
Neuroimagem Funcional
Seres Humanos
Imagem por Ressonância Magnética
Plasticidade Neuronal
Paresia/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160728
[St] Status:MEDLINE
[do] DOI:10.1055/s-0036-1586223


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[PMID]:27262774
[Au] Autor:Carlson HL; Jadavji Z; Mineyko A; Damji O; Hodge J; Saunders J; Hererro M; Nowak M; Patzelt R; Mazur-Mosiewicz A; MacMaster FP; Kirton A
[Ad] Endereço:Calgary Pediatric Stroke Program, Alberta Children's Hospital, Calgary, AB, Canada; Alberta Children's Hospital Research Institute (ACHRI), Calgary, AB, Canada; Department of Neurosciences, Alberta Children's Hospital, Calgary, AB, Canada. Electronic address: Helen.carlson@albertahealthservices.ca.
[Ti] Título:Treatment of dysphasia with rTMS and language therapy after childhood stroke: Multimodal imaging of plastic change.
[So] Source:Brain Lang;159:23-34, 2016 Aug.
[Is] ISSN:1090-2155
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Expressive dysphasia accompanies left inferior frontal gyrus (IFG/Broca) injury. Recovery may relate to interhemispheric balance with homologous, contralesional IFG but is unexplored in children. We evaluated effects of inhibitory rTMS to contralesional IFG combined with intensive speech therapy (SLT). A 15year-old, right-handed male incurred a left middle cerebral artery stroke. After 30months, severe non-fluent dysphasia impacted quality of life. Language networks, neuronal metabolism and white matter pathways were explored using MRI. Language function was measured longitudinally. An intensive SLT program was combined with contralesional inhibitory rTMS of right pars triangularis. Procedures were well tolerated. Language function improved persisting to four months. Post-treatment fMRI demonstrated increased left perilesional IFG activations and connectivity at rest. Bilateral changes in inositol and glutamate metabolism were observed. Contralesional, inhibitory rTMS appears safe in childhood stroke-induced dysphasia. We observed clinically significant improvements after SLT coupled with rTMS. Advanced neuroimaging can evaluate intervention-induced plasticity.
[Mh] Termos MeSH primário: Afasia de Broca/terapia
Mapeamento Encefálico
Terapia da Linguagem
Imagem Multimodal
Plasticidade Neuronal
Acidente Vascular Cerebral/complicações
Estimulação Magnética Transcraniana
[Mh] Termos MeSH secundário: Adolescente
Afasia de Broca/etiologia
Afasia de Broca/patologia
Afasia de Broca/fisiopatologia
Área de Broca/patologia
Área de Broca/fisiopatologia
Lateralidade Funcional
Ácido Glutâmico/metabolismo
Seres Humanos
Infarto da Artéria Cerebral Média/fisiopatologia
Infarto da Artéria Cerebral Média/terapia
Inositol/metabolismo
Imagem por Ressonância Magnética
Masculino
Neurônios/metabolismo
Qualidade de Vida
Descanso
Fonoterapia
Acidente Vascular Cerebral/patologia
Acidente Vascular Cerebral/fisiopatologia
Acidente Vascular Cerebral/terapia
Estimulação Magnética Transcraniana/efeitos adversos
Substância Branca/patologia
Substância Branca/fisiopatologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
3KX376GY7L (Glutamic Acid); 4L6452S749 (Inositol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160606
[St] Status:MEDLINE


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[PMID]:27177100
[Au] Autor:Wu Q; Hu X; Wen X; Li F; Fu W
[Ad] Endereço:The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
[Ti] Título:Clinical study of acupuncture treatment on motor aphasia after stroke.
[So] Source:Technol Health Care;24 Suppl 2:S691-6, 2016 Apr 29.
[Is] ISSN:1878-7401
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To study the safety and effectiveness of the Heart-Gallbladder acupuncture treatment for motor aphasia after stroke via clinical studies. METHODS: Sixty valid patients were divided into two groups randomly with a ratio of 1:1. The treatment group was the Heart-Gallbladder acupuncture group and the control group was the conventional acupuncture group. The two groups underwent testing before and after treatments, which included: the Aphasia Battery of Chinese (ABC), the Chinese functional communication profile (CFCP), and the Boston diagnostic aphasia examination (BDAE). RESULTS: All the BDAE, CFCP and ABC results showed a significant difference between the two groups after treatment (P< 0.05), indicating that the Heart-Gallbladder acupuncture treatment for motor aphasia after stroke can reduce the degree of aphasia and improve patients' daily communication skills more than the conventional acupuncture treatment. The Heart-Gallbladder acupuncture treatment is better than the conventional acupuncture treatments for motor aphasia after stroke, with significantly improved scores for fluency, repetition, naming, and reading. CONCLUSIONS: Both the Heart-Gallbladder acupuncture and the conventional acupuncture are effective in the treatment of motor aphasia after stroke. Nevertheless, when compared to the conventional acupuncture, the Heart-Gallbladder acupuncture had better efficacy and it is safe as well.
[Mh] Termos MeSH primário: Terapia por Acupuntura
Afasia de Broca/terapia
Acidente Vascular Cerebral/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
China
Seres Humanos
Meia-Idade
Língua
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160514
[St] Status:MEDLINE
[do] DOI:10.3233/THC-161197


  10 / 1498 MEDLINE  
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[PMID]:27054439
[Au] Autor:Fischer-Baum S; Miozzo M; Laiacona M; Capitani E
[Ad] Endereço:Department of Psychology.
[Ti] Título:Perseveration during verbal fluency in traumatic brain injury reflects impairments in working memory.
[So] Source:Neuropsychology;30(7):791-9, 2016 Oct.
[Is] ISSN:1931-1559
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Previous studies of verbal fluency have reported higher rates of perseverative responses in both Alzheimer's disease (AD) and traumatic brain injury (TBI) relative to control groups. These perseverations could arise from a number of impairments-for example, failures in working memory, inhibitory control, or word retrieval-and different clinical populations may show an increase in perseveration because of different underlying deficits. The objective of the current report is to investigate the cause of perseveration in verbal fluency in individuals with TBI and compare those results to a recent study of individuals with AD. METHOD: In a previous study, conducted by Miozzo, Fischer-Baum, and Caccappolo-van Vliet (2013), perseveration errors produced by individuals with AD were shown to have long lags between the 1st occurrence of a word and its repetition in verbal fluency, suggesting that perseverations were caused by a failure of the working memory mechanisms that control response monitoring. In the present investigation, we applied the same analysis to the perseveration errors produced during 197 administrations of the verbal fluency task with 143 individuals with TBI. RESULTS: The perseverations of individuals with TBI showed a lag distribution similar to that of the AD population, with the lag between the 1st occurrence of a word and its repetition systematically longer than would be expected by chance. CONCLUSIONS: These results suggest that the perseverations produced during verbal fluency in individuals with TBI stem from the same working memory mechanism proposed in AD, rather than inhibitory control or word retrieval deficits. (PsycINFO Database Record
[Mh] Termos MeSH primário: Afasia de Broca/diagnóstico
Afasia de Broca/psicologia
Dano Encefálico Crônico/diagnóstico
Dano Encefálico Crônico/psicologia
Lesões Encefálicas Traumáticas/diagnóstico
Lesões Encefálicas Traumáticas/psicologia
Transtornos da Memória/diagnóstico
Transtornos da Memória/psicologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Memória de Curto Prazo
Meia-Idade
Testes Neuropsicológicos
Medida da Produção da Fala
Comportamento Verbal
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; WEBCASTS
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160408
[St] Status:MEDLINE
[do] DOI:10.1037/neu0000286



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