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Pesquisa : C10.597.606.150.500.800.100.166 [Categoria DeCS]
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[PMID]:28259857
[Au] Autor:Woodhead ZV; Crinion J; Teki S; Penny W; Price CJ; Leff AP
[Ad] Endereço:Department of Brain Repair and Rehabilitation, University College London, London, UK.
[Ti] Título:Auditory training changes temporal lobe connectivity in 'Wernicke's aphasia': a randomised trial.
[So] Source:J Neurol Neurosurg Psychiatry;88(7):586-594, 2017 Jul.
[Is] ISSN:1468-330X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Aphasia is one of the most disabling sequelae after stroke, occurring in 25%-40% of stroke survivors. However, there remains a lack of good evidence for the efficacy or mechanisms of speech comprehension rehabilitation. TRIAL DESIGN: This within-subjects trial tested two concurrent interventions in 20 patients with chronic aphasia with speech comprehension impairment following left hemisphere stroke: (1) phonological training using 'Earobics' software and (2) a pharmacological intervention using donepezil, an acetylcholinesterase inhibitor. Donepezil was tested in a double-blind, placebo-controlled, cross-over design using block randomisation with bias minimisation. METHODS: The primary outcome measure was speech comprehension score on the comprehensive aphasia test. Magnetoencephalography (MEG) with an established index of auditory perception, the mismatch negativity response, tested whether the therapies altered effective connectivity at the lower (primary) or higher (secondary) level of the auditory network. RESULTS: Phonological training improved speech comprehension abilities and was particularly effective for patients with severe deficits. No major adverse effects of donepezil were observed, but it had an unpredicted negative effect on speech comprehension. The MEG analysis demonstrated that phonological training increased synaptic gain in the left superior temporal gyrus (STG). Patients with more severe speech comprehension impairments also showed strengthening of bidirectional connections between the left and right STG. CONCLUSIONS: Phonological training resulted in a small but significant improvement in speech comprehension, whereas donepezil had a negative effect. The connectivity results indicated that training reshaped higher order phonological representations in the left STG and (in more severe patients) induced stronger interhemispheric transfer of information between higher levels of auditory cortex.Clinical trial registrationThis trial was registered with EudraCT (2005-004215-30, https:// .ema.europa.eu/) and ISRCTN (68939136, http://www.isrctn.com/).
[Mh] Termos MeSH primário: Afasia de Wernicke/fisiopatologia
Percepção Auditiva/fisiologia
Lobo Temporal/patologia
[Mh] Termos MeSH secundário: Afasia de Wernicke/diagnóstico por imagem
Inibidores da Colinesterase/uso terapêutico
Compreensão/fisiologia
Método Duplo-Cego
Feminino
Seres Humanos
Indanos/uso terapêutico
Magnetoencefalografia/métodos
Masculino
Meia-Idade
Testes Neuropsicológicos
Piperidinas/uso terapêutico
Percepção da Fala/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Cholinesterase Inhibitors); 0 (Indans); 0 (Piperidines); 8SSC91326P (donepezil)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171114
[Lr] Data última revisão:
171114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170306
[St] Status:MEDLINE
[do] DOI:10.1136/jnnp-2016-314621


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[PMID]:28093855
[Au] Autor:Kawakatsu S; Kobayashi R; Hayashi H
[Ad] Endereço:Department of Neuropsychiatry, Aizu Medical Center, Fukushima Medical University, Aizuwakamatsu, Japan.
[Ti] Título:Typical and atypical appearance of early-onset Alzheimer's disease: A clinical, neuroimaging and neuropathological study.
[So] Source:Neuropathology;37(2):150-173, 2017 Apr.
[Is] ISSN:1440-1789
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:The International Working Group (IWG) has classified Alzheimer's disease (AD) as two different types, the typical form and the atypical form, but clinicopathological studies of atypical AD are limited. Because atypical AD cases usually present with early-onset dementia, we investigated 12 patients with early-onset AD, including two patients with typical AD and 10 patients with atypical AD. Of these patients, six had the posterior variant, three had the frontal variant and one had the logopenic variant mixed with semantic dementia. We reported MRI, single-photon emission CT and neuropathological findings in six representative cases. We also described a "left temporal variant" of AD presenting with transcortical cortical sensory aphasia, which has not been reported previously and is another subtype of the posterior variant of AD. We found a significant correlation between regional cerebral blood flow and counts of NFTs in the cerebral cortices. An atypical presentation with focal neuropsychological symptoms roughly correlated with the density of NFTs in the cerebral cortex and more directly related to spongiform changes in the superficial layers of these areas. In contrast, the distribution of amyloid depositions was diffuse and did not necessarily correlate with focal neuropsychological symptoms. Braak staging or ABC score is not necessarily appropriate to evaluate atypical AD, and instead, spongiform changes in addition to tau pathology in the association cortices better explain the diversity of atypical AD. Interestingly, another patient with a posterior variant of AD had a novel type of atypical plaque, which we referred to as "lucent plaque". They were recognizable with HE staining in the circumference and dystrophic neurites were abundant with Gallyas-Braak staining. These plaques demonstrated intense immunoreactivity to both tau AT-8 and amyloid ß (Aß), suggesting a peculiar coexistence pattern of amyloid and tau in these plaques. Clinicopathological studies of atypical AD will provide a new understanding of the pathophysiology of AD.
[Mh] Termos MeSH primário: Doença de Alzheimer/patologia
Encéfalo/patologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Doença de Alzheimer/classificação
Doença de Alzheimer/complicações
Doença de Alzheimer/diagnóstico por imagem
Afasia de Wernicke/complicações
Atrofia/complicações
Encéfalo/irrigação sanguínea
Encéfalo/diagnóstico por imagem
Feminino
Síndrome de Gerstmann/complicações
Síndrome de Gerstmann/diagnóstico por imagem
Síndrome de Gerstmann/patologia
Seres Humanos
Masculino
Meia-Idade
Emaranhados Neurofibrilares/patologia
Neuroimagem
Placa Amiloide/complicações
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170118
[St] Status:MEDLINE
[do] DOI:10.1111/neup.12364


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[PMID]:27483560
[Au] Autor:Savic G
[Ti] Título:Ability to solve riddles in patients with speech and language impairments after stroke.
[So] Source:Srp Arh Celok Lek;144(3-4):158-64, 2016 Mar-Apr.
[Is] ISSN:0370-8179
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Successful riddle solving requires recognition of the meaning of words, attention, concentration, memory, connectivity and analysis of riddle content, and sufficiently developed associative thinking. OBJECTIVE: The aim of the study was to determine the ability to solve riddles in stroke patients who do or do not have speech and language disorders (SLDs), to determine the presence of SLDs in relation to the lesion localization, as well as to define the relationship between riddle-solving and functional impairment of a body side. METHODS: The sample consisted of 88 patients. The data used included age, sex, educational level, time of stroke onset, presence of an SLD, lesion localization, and functional damage of the body side. The patients were presented with a task of solving 10 riddles. RESULTS: A significant SLD was present in 38.60% of the patients. Brain lesions were found distributed at 46 different brain sites. Patients with different lesion localization had different success in solving riddles. Patients with perisylvian cortex brain lesions, or patients with Wernicke and global aphasia, had the poorest results. The group with SLDs had an average success of solved riddles of 26.76% (p = 0.000). The group with right-sided functional impairments had average success of 37.14%, and the group with functional impairments of the left side of the body 56.88% (p = 0.002). CONCLUSION: Most patients with SLDs had a low ability of solving riddles. Most of the patients with left brain lesions and perisylvian cortex damage demonstrated lower ability in solving riddles in relation to patients with right hemisphere lesions.
[Mh] Termos MeSH primário: Afasia de Wernicke/fisiopatologia
Afasia/fisiopatologia
Encéfalo/fisiopatologia
Acidente Vascular Cerebral/fisiopatologia
[Mh] Termos MeSH secundário: Idoso
Afasia/etiologia
Afasia de Wernicke/etiologia
Encéfalo/patologia
Feminino
Lateralidade Funcional
Seres Humanos
Linguagem
Transtornos da Linguagem/etiologia
Transtornos da Linguagem/fisiopatologia
Masculino
Meia-Idade
Testes Neuropsicológicos
Fala
Distúrbios da Fala/etiologia
Distúrbios da Fala/fisiopatologia
Acidente Vascular Cerebral/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160803
[Lr] Data última revisão:
160803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160804
[St] Status:MEDLINE


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[PMID]:27445249
[Au] Autor:Camsari GB; Murray ME; Graff-Radford NR
[Ad] Endereço:Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA.
[Ti] Título:Case Studies Illustrating Focal Alzheimer's, Fluent Aphasia, Late-Onset Memory Loss, and Rapid Dementia.
[So] Source:Neurol Clin;34(3):699-716, 2016 Aug.
[Is] ISSN:1557-9875
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Many dementia subtypes have more shared signs and symptoms than defining ones. We review 8 cases with 4 overlapping syndromes and demonstrate how to distinguish the cases. These include focal cortical presentations of Alzheimer's disease (AD; posterior cortical atrophy and corticobasal syndrome [CBS]), fluent aphasia (semantic dementia and logopenic aphasia), late-onset slowly progressive dementia (hippocampal sclerosis and limbic predominant AD) and rapidly progressive dementia (Creutzfeldt-Jakob disease and limbic encephalitis). Recognizing the different syndromes can help the clinician to improve their diagnostic skills, leading to improved patient outcomes by early and accurate diagnosis, prompt treatment, and appropriate counseling and guidance.
[Mh] Termos MeSH primário: Afasia de Wernicke/diagnóstico
Demência/diagnóstico
Transtornos da Memória/etiologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Doença de Alzheimer/diagnóstico
Afasia de Wernicke/etiologia
Demência/etiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Fatores de Tempo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160723
[St] Status:MEDLINE


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[PMID]:27061639
[Au] Autor:Kozintseva E; Skvortsov A
[Ad] Endereço:Department of Medical Psychology, Center for Speech Pathology and Neurorehabilitation, Moscow, Russia.
[Ti] Título:Variability of writing disorders in Wernicke's aphasia underperforming different writing tasks: A single-case study.
[So] Source:Psych J;5(1):18-30, 2016 Mar.
[Is] ISSN:2046-0260
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:The aim of our study was to evolve views on writing disorders in Wernicke's agraphia by comparing group data and analysis of a single patient. We showed how a single-case study can be useful in obtaining essential results that can be hidden by averaging group data. Analysis of a single patient proved to be important for resolving contradictions of the "holistic" and "elementaristic" paradigms of psychology and for the development of theoretical knowledge with the example of a writing disorder. The implementation of a holistic approach was undertaken by presenting the tasks differing in functions in which writing had been performed since its appearance in human culture (communicative, mnestic, and regulatory). In spite of the identical composition of involved psychological components, these differences were identified when certain types of errors were analyzed in the single subject. The results are discussed in terms of used writing strategy, resulting in a way of operation of involved components that lead to qualitative and quantitative changes of writing errors within the syndrome of Wernicke's agraphia.
[Mh] Termos MeSH primário: Afasia de Wernicke/psicologia
Modelos Psicológicos
[Mh] Termos MeSH secundário: Adulto
Idoso
Agrafia/psicologia
Afasia de Wernicke/classificação
Feminino
Escrita Manual
Seres Humanos
Masculino
Meia-Idade
Testes Neuropsicológicos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170110
[Lr] Data última revisão:
170110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160411
[St] Status:MEDLINE
[do] DOI:10.1002/pchj.130


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[PMID]:26943459
[Au] Autor:Carota A; Rimoldi F; Calabrese P
[Ad] Endereço:GSMN Neurocenter, Genolier Clinic, Genolier Swiss Medical Network, Route du Muids 3, CP 100, 1272, Genolier, Switzerland. acarota@genolier.net.
[Ti] Título:Wernicke's aphasia and attempted suicide.
[So] Source:Acta Neurol Belg;116(4):659-661, 2016 Dec.
[Is] ISSN:2240-2993
[Cp] País de publicação:Italy
[La] Idioma:eng
[Mh] Termos MeSH primário: Afasia de Wernicke/psicologia
Tentativa de Suicídio/psicologia
[Mh] Termos MeSH secundário: Idoso
Afasia de Wernicke/etiologia
Seres Humanos
Masculino
Acidente Vascular Cerebral/complicações
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170117
[Lr] Data última revisão:
170117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160305
[St] Status:MEDLINE


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[PMID]:26808838
[Au] Autor:Kurowski K; Blumstein SE
[Ad] Endereço:Department of Cognitive Linguistic & Psychological Sciences, Brown University, Providence, RI United States.
[Ti] Título:Phonetic basis of phonemic paraphasias in aphasia: Evidence for cascading activation.
[So] Source:Cortex;75:193-203, 2016 Feb.
[Is] ISSN:1973-8102
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Phonemic paraphasias are a common presenting symptom in aphasia and are thought to reflect a deficit in which selecting an incorrect phonemic segment results in the clear-cut substitution of one phonemic segment for another. The current study re-examines the basis of these paraphasias. Seven left hemisphere-damaged aphasics with a range of left hemisphere lesions and clinical diagnoses including Broca's, Conduction, and Wernicke's aphasia, were asked to produce syllable-initial voiced and voiceless fricative consonants, [z] and [s], in CV syllables followed by one of five vowels [i e a o u] in isolation and in a carrier phrase. Acoustic analyses were conducted focusing on two acoustic parameters signaling voicing in fricative consonants: duration and amplitude properties of the fricative noise. Results show that for all participants, regardless of clinical diagnosis or lesion site, phonemic paraphasias leave an acoustic trace of the original target in the error production. These findings challenge the view that phonemic paraphasias arise from a mis-selection of phonemic units followed by its correct implementation, as traditionally proposed. Rather, they appear to derive from a common mechanism with speech errors reflecting the co-activation of a target and competitor resulting in speech output that has some phonetic properties of both segments.
[Mh] Termos MeSH primário: Afasia de Broca/fisiopatologia
Afasia de Wernicke/fisiopatologia
Fonética
Fala/fisiologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Meia-Idade
Medida da Produção da Fala/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170725
[Lr] Data última revisão:
170725
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160126
[St] Status:MEDLINE


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[PMID]:26705270
[Au] Autor:Robinson GA; Butterworth B; Cipolotti L
[Ad] Endereço:*Neuropsychology Research Unit, School of Psychology, The University of Queensland, Brisbane, Queensland, Australia †Department of Neuropsychology, National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom ‡Institute of Cognitive Neuroscience, University College, London, United Kingdom §Department of Psychology, University of Palermo, Palermo, Italy.
[Ti] Título:"My Mind Is Doing It All": No "Brake" to Stop Speech Generation in Jargon Aphasia.
[So] Source:Cogn Behav Neurol;28(4):229-41, 2015 Dec.
[Is] ISSN:1543-3641
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To study whether pressure of speech in jargon aphasia arises out of disturbances to core language or executive processes, or at the intersection of conceptual preparation. BACKGROUND: Conceptual preparation mechanisms for speech have not been well studied. Several mechanisms have been proposed for jargon aphasia, a fluent, well-articulated, logorrheic propositional speech that is almost incomprehensible. METHODS: We studied the vast quantity of jargon speech produced by patient J.A., who had suffered an infarct after the clipping of a middle cerebral artery aneurysm. We gave J.A. baseline cognitive tests and experimental word- and sentence-generation tasks that we had designed for patients with dynamic aphasia, a severely reduced but otherwise fairly normal propositional speech thought to result from deficits in conceptual preparation. RESULTS: J.A. had cognitive dysfunction, including executive difficulties, and a language profile characterized by poor repetition and naming in the context of relatively intact single-word comprehension. J.A.'s spontaneous speech was fluent but jargon. He had no difficulty generating sentences; in contrast to dynamic aphasia, his sentences were largely meaningless and not significantly affected by stimulus constraint level. CONCLUSIONS: This patient with jargon aphasia highlights that voluminous speech output can arise from disturbances of both language and executive functions. Our previous studies have identified three conceptual preparation mechanisms for speech: generation of novel thoughts, their sequencing, and selection. This study raises the possibility that a "brake" to stop message generation may be a fourth conceptual preparation mechanism behind the pressure of speech characteristic of jargon aphasia.
[Mh] Termos MeSH primário: Afasia de Wernicke/fisiopatologia
Transtornos Cognitivos/fisiopatologia
Função Executiva/fisiologia
[Mh] Termos MeSH secundário: Idoso
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151225
[Lr] Data última revisão:
151225
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151226
[St] Status:MEDLINE
[do] DOI:10.1097/WNN.0000000000000080


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[PMID]:26465238
[Au] Autor:Yourganov G; Smith KG; Fridriksson J; Rorden C
[Ad] Endereço:Department of Psychology, University of South Carolina, Columbia, SC, USA. Electronic address: yourgano@musc.edu.
[Ti] Título:Predicting aphasia type from brain damage measured with structural MRI.
[So] Source:Cortex;73:203-15, 2015 Dec.
[Is] ISSN:1973-8102
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Chronic aphasia is a common consequence of a left-hemisphere stroke. Since the early insights by Broca and Wernicke, studying the relationship between the loci of cortical damage and patterns of language impairment has been one of the concerns of aphasiology. We utilized multivariate classification in a cross-validation framework to predict the type of chronic aphasia from the spatial pattern of brain damage. Our sample consisted of 98 patients with five types of aphasia (Broca's, Wernicke's, global, conduction, and anomic), classified based on scores on the Western Aphasia Battery (WAB). Binary lesion maps were obtained from structural MRI scans (obtained at least 6 months poststroke, and within 2 days of behavioural assessment); after spatial normalization, the lesions were parcellated into a disjoint set of brain areas. The proportion of damage to the brain areas was used to classify patients' aphasia type. To create this parcellation, we relied on five brain atlases; our classifier (support vector machine - SVM) could differentiate between different kinds of aphasia using any of the five parcellations. In our sample, the best classification accuracy was obtained when using a novel parcellation that combined two previously published brain atlases, with the first atlas providing the segmentation of grey matter, and the second atlas used to segment the white matter. For each aphasia type, we computed the relative importance of different brain areas for distinguishing it from other aphasia types; our findings were consistent with previously published reports of lesion locations implicated in different types of aphasia. Overall, our results revealed that automated multivariate classification could distinguish between aphasia types based on damage to atlas-defined brain areas.
[Mh] Termos MeSH primário: Afasia de Broca/diagnóstico
Afasia de Wernicke/diagnóstico
Encéfalo/patologia
Imagem por Ressonância Magnética
Acidente Vascular Cerebral/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Afasia de Broca/patologia
Afasia de Wernicke/patologia
Lesões Encefálicas/patologia
Diagnóstico Diferencial
Feminino
Seres Humanos
Imagem por Ressonância Magnética/métodos
Masculino
Meia-Idade
Acidente Vascular Cerebral/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1609
[Cu] Atualização por classe:161201
[Lr] Data última revisão:
161201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151015
[St] Status:MEDLINE


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[PMID]:26454668
[Au] Autor:Thompson HE; Robson H; Lambon Ralph MA; Jefferies E
[Ad] Endereço:1 Department of Psychology and York Neuroimaging Centre, University of York, UK hannah.thompson@york.ac.uk.
[Ti] Título:Varieties of semantic 'access' deficit in Wernicke's aphasia and semantic aphasia.
[So] Source:Brain;138(Pt 12):3776-92, 2015 Dec.
[Is] ISSN:1460-2156
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Comprehension deficits are common in stroke aphasia, including in cases with (i) semantic aphasia, characterized by poor executive control of semantic processing across verbal and non-verbal modalities; and (ii) Wernicke's aphasia, associated with poor auditory-verbal comprehension and repetition, plus fluent speech with jargon. However, the varieties of these comprehension problems, and their underlying causes, are not well understood. Both patient groups exhibit some type of semantic 'access' deficit, as opposed to the 'storage' deficits observed in semantic dementia. Nevertheless, existing descriptions suggest that these patients might have different varieties of 'access' impairment-related to difficulty resolving competition (in semantic aphasia) versus initial activation of concepts from sensory inputs (in Wernicke's aphasia). We used a case series design to compare patients with Wernicke's aphasia and those with semantic aphasia on Warrington's paradigmatic assessment of semantic 'access' deficits. In these verbal and non-verbal matching tasks, a small set of semantically-related items are repeatedly presented over several cycles so that the target on one trial becomes a distractor on another (building up interference and eliciting semantic 'blocking' effects). Patients with Wernicke's aphasia and semantic aphasia were distinguished according to lesion location in the temporal cortex, but in each group, some individuals had additional prefrontal damage. Both of these aspects of lesion variability-one that mapped onto classical 'syndromes' and one that did not-predicted aspects of the semantic 'access' deficit. Both semantic aphasia and Wernicke's aphasia cases showed multimodal semantic impairment, although as expected, the Wernicke's aphasia group showed greater deficits on auditory-verbal than picture judgements. Distribution of damage in the temporal lobe was crucial for predicting the initially 'beneficial' effects of stimulus repetition: cases with Wernicke's aphasia showed initial improvement with repetition of words and pictures, while in semantic aphasia, semantic access was initially good but declined in the face of competition from previous targets. Prefrontal damage predicted the 'harmful' effects of repetition: the ability to reselect both word and picture targets in the face of mounting competition was linked to left prefrontal damage in both groups. Therefore, patients with semantic aphasia and Wernicke's aphasia have partially distinct impairment of semantic 'access' but, across these syndromes, prefrontal lesions produce declining comprehension with repetition in both verbal and non-verbal tasks.
[Mh] Termos MeSH primário: Afasia de Wernicke/fisiopatologia
Afasia de Wernicke/psicologia
Afasia/fisiopatologia
Afasia/psicologia
Compreensão
Semântica
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Afasia/patologia
Afasia de Wernicke/patologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Testes Neuropsicológicos
Córtex Pré-Frontal/patologia
Córtex Pré-Frontal/fisiopatologia
Lobo Temporal/patologia
Lobo Temporal/fisiopatologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1605
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:151012
[St] Status:MEDLINE
[do] DOI:10.1093/brain/awv281



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde