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Pesquisa : C10.597.606.150.500.800.500 [Categoria DeCS]
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[PMID]:28498095
[Au] Autor:Pols SYCV; van Veelen MLC; Aarsen FK; Gonzalez Candel A; Catsman-Berrevoets CE
[Ad] Endereço:Departments of 1 Pediatric Neurology.
[Ti] Título:Risk factors for development of postoperative cerebellar mutism syndrome in children after medulloblastoma surgery.
[So] Source:J Neurosurg Pediatr;20(1):35-41, 2017 Jul.
[Is] ISSN:1933-0715
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE Postoperative cerebellar mutism syndrome (pCMS) occurs in 7%-50% of children after cerebellar tumor surgery. Typical features include a latent onset of 1-2 days after surgery, transient mutism, emotional lability, and a wide variety of motor and neurobehavioral abnormalities. Sequelae of this syndrome usually persist long term. The principal causal factor is bilateral surgical damage (regardless of tumor location) to any component of the proximal efferent cerebellar pathway, which leads to temporary dysfunction of cerebral cortical regions as a result of diaschisis. Tumor type, cerebellar midline location, and brainstem involvement are risk factors for pCMS that have been identified repeatedly, but they do not explain its latent onset. Ambiguous or negative results for other factors, such as hydrocephalus, postoperative meningitis, length of vermian incision, and tumor size, have been reached. The aim of this study was to identify perioperative clinical, radiological, and laboratory factors that also increase risk for the development of pCMS. The focus was on factors that might explain the delayed onset of pCMS and thus might provide a time window for taking precautionary measures to prevent pCMS or reduce its severity. The study was focused specifically on children who had undergone surgery for medulloblastoma. METHODS In this single-center retrospective cohort study, the authors included 71 children with medulloblastoma, 28 of whom developed pCMS after primary resection. Clinical and laboratory data were collected prospectively and analyzed systematically. Variables were included for univariate and multivariate analysis. RESULTS Univariate regression analysis revealed 7 variables that had a significant influence on pCMS onset, namely, tumor size, maximum tumor diameter > 5 cm, tumor infiltration or compression of the brainstem, significantly larger decreases in hemoglobin (p = 0.010) and hematocrit (p = 0.003) in the pCMS group after surgery than in the no-pCMS group, significantly more reported incidents of severe bleeding in the tumor bed during surgery in the pCMS group, preoperative hydrocephalus, and a mean body temperature rise of 0.5°C in the first 4 days after surgery in the pCMS group. Multiple regression analysis revealed that tumor size, tumor infiltration into or compression of the brainstem, and higher mean body temperature in the first 4 postoperative days were independent and highly significant predictors for pCMS. CONCLUSIONS The authors confirmed earlier findings that tumor-associated preoperative conditions, such as a maximum tumor diameter ≥ 5 cm and infiltration into or compression of the brainstem, are associated with a higher risk for the development of pCMS. Most importantly, the authors found that a 0.5°C higher mean body temperature in the first 4 postoperative days increased the odds ratio for the development of pCMS almost 5-fold. These data suggest that an important focus for the prevention of pCMS in children who have undergone medulloblastoma surgery might be rigorous maintenance of normothermia as standard care after surgery.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/complicações
Neoplasias Encefálicas/cirurgia
Meduloblastoma/complicações
Meduloblastoma/cirurgia
Mutismo/etiologia
Complicações Pós-Operatórias
[Mh] Termos MeSH secundário: Adolescente
Biomarcadores/sangue
Encéfalo/diagnóstico por imagem
Encéfalo/cirurgia
Neoplasias Encefálicas/diagnóstico por imagem
Neoplasias Encefálicas/epidemiologia
Criança
Pré-Escolar
Seres Humanos
Incidência
Imagem por Ressonância Magnética
Meduloblastoma/diagnóstico por imagem
Meduloblastoma/epidemiologia
Análise Multivariada
Mutismo/diagnóstico por imagem
Mutismo/epidemiologia
Procedimentos Neurocirúrgicos
Complicações Pós-Operatórias/diagnóstico por imagem
Complicações Pós-Operatórias/epidemiologia
Análise de Regressão
Estudos Retrospectivos
Fatores de Risco
Síndrome
Carga Tumoral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170513
[St] Status:MEDLINE
[do] DOI:10.3171/2017.2.PEDS16605


  2 / 931 MEDLINE  
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[PMID]:28181389
[Au] Autor:Sheth J; Ranjan G; Shah K; Bhavsar R; Sheth F
[Ad] Endereço:FRIGE's Institute of Human Genetics, Ahmedabad, Gujarat, India.
[Ti] Título:Novel LINS1 missense mutation in a family with non-syndromic intellectual disability.
[So] Source:Am J Med Genet A;173(4):1041-1046, 2017 Apr.
[Is] ISSN:1552-4833
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Newer sequencing technologies decipher molecular variations and increase the knowledge of pathogenesis of complex diseases like intellectual disability (ID), affecting 2-3% of the population. We report a novel family with a missense mutation in LINS1 as a cause for non-syndromic ID. Clinical exome sequencing for ID related genes carried out for a male with dysmorphism, mutism, and cognitive delay was uninformative. Subsequently, "pathogenic" and "likely pathogenic" variants associated with other inherited disorders were searched for as secondary findings. Further, PCR-RFLP carried out in other family members confirmed the result. A novel missense variant (c.937G>A) in exon 5 of LINS1 was detected in the proband. His affected elder brother was homozygous and the parents were heterozygous respectively, for the mutation. No mutation was observed in his unaffected sister. Mutations in LINS1 were suspected in this non-syndromic ID case with mutism. LINS1 alterations affect ELAV1 expression and result in reduction in the commissural axonal growth, thus affecting peripheral and central neuronal function. LINS1 acts in association with ß-catenin to influence WNT1 signaling. It is hypothesized that mutations in LINS1 may alter HuR expression during neural differentiation, leading to ID in humans. © 2017 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Deficiência Intelectual/genética
Mutação de Sentido Incorreto
Mutismo/genética
Proteínas/genética
[Mh] Termos MeSH secundário: Sequência de Bases
Exoma
Família
Feminino
Expressão Gênica
Heterozigoto
Sequenciamento de Nucleotídeos em Larga Escala
Homozigoto
Seres Humanos
Deficiência Intelectual/diagnóstico
Deficiência Intelectual/fisiopatologia
Masculino
Modelos Moleculares
Mutismo/diagnóstico
Mutismo/fisiopatologia
Linhagem
Polimorfismo de Fragmento de Restrição
Estrutura Secundária de Proteína
Proteínas/química
Proteínas/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (LINS protein, human); 0 (Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170210
[St] Status:MEDLINE
[do] DOI:10.1002/ajmg.a.38089


  3 / 931 MEDLINE  
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[PMID]:28118217
[Au] Autor:Chao JY; Liu C; Shetty N; Shah U
[Ad] Endereço:From the *Department of Anesthesiology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York; and †Department of Anesthesiology, Rutgers University-Robert Wood Johnson University Hospital, New Brunswick, New Jersey.
[Ti] Título:Postoperative Pediatric Cerebellar Mutism After Posterior Fossa Surgery: A Case Report.
[So] Source:A A Case Rep;8(8):213-215, 2017 Apr 15.
[Is] ISSN:2325-7237
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cerebellar mutism syndrome (CMS) is a common complication of posterior fossa surgery that can confound the postanesthetic examination and have long-lasting impacts. There is confusion surrounding its precise description, diagnostic features, and associated morbidity. Here, we discuss the most up-to-date knowledge of CMS drawing from a clinical case in the context of 3 new reports: (1) an international consensus paper presenting a new proposed working definition by the Iceland Delphi Group, (2) a knowledge update by Gadgil et al, (3) and a review of neuroimaging-based data elucidating the etiology of CMS by Patay.
[Mh] Termos MeSH primário: Doenças Cerebelares/etiologia
Fossa Craniana Posterior/cirurgia
Mutismo/etiologia
Complicações Pós-Operatórias/diagnóstico
[Mh] Termos MeSH secundário: Doenças Cerebelares/reabilitação
Criança
Gerenciamento Clínico
Feminino
Seres Humanos
Mutismo/reabilitação
Terapia Ocupacional
Modalidades de Fisioterapia
Complicações Pós-Operatórias/reabilitação
Fonoterapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE
[do] DOI:10.1213/XAA.0000000000000467


  4 / 931 MEDLINE  
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[PMID]:28050719
[Au] Autor:Nicita F; Paiano M; Liberatore M; Spalice A; Papoff P; Ullo M; Piccirilli M; Clerico A; Schiavetti A
[Ad] Endereço:Child Neurology Division, Department of Pediatrics and Child Neuropsychiatry, Umberto I Hospital, Sapienza University of Rome, Viale Regina Elena 324, 00161, Roma, Italy. nicita.f@gmail.com.
[Ti] Título:Sudden benzodiazepine-induced resolution of post-operative pediatric cerebellar mutism syndrome: a clinical-SPECT study.
[So] Source:Acta Neurochir (Wien);159(3):475-479, 2017 Mar.
[Is] ISSN:0942-0940
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Post-operative pediatric cerebellar mutism syndrome (PPCMS) is a clinical syndrome arising from cerebellar injury and characterized by absence of speech and other possible symptoms and signs. Rare reports described some benefit after administration of dopamine agonist therapy, but no treatment has proven efficacy. In this paper, we report on the dramatic, sudden resolution of PPCMS induced by midazolam administration in a boy who underwent posterior fossa surgery for choroid plexus papilloma of the fourth ventricle. In addition to clinical improvement, post-midazolam single-photon emission computed tomography also demonstrated amelioration of brain perfusion.
[Mh] Termos MeSH primário: Benzodiazepinas/farmacologia
Doenças Cerebelares/tratamento farmacológico
Neoplasias do Ventrículo Cerebral/cirurgia
Hipnóticos e Sedativos/farmacologia
Midazolam/farmacologia
Mutismo/tratamento farmacológico
Mutismo/etiologia
Papiloma/cirurgia
Complicações Pós-Operatórias/tratamento farmacológico
[Mh] Termos MeSH secundário: Adolescente
Doenças Cerebelares/etiologia
Fossa Craniana Posterior/cirurgia
Seres Humanos
Hipnóticos e Sedativos/administração & dosagem
Masculino
Midazolam/administração & dosagem
Complicações Pós-Operatórias/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypnotics and Sedatives); 12794-10-4 (Benzodiazepines); R60L0SM5BC (Midazolam)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170105
[St] Status:MEDLINE
[do] DOI:10.1007/s00701-016-3059-y


  5 / 931 MEDLINE  
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[PMID]:27977468
[Au] Autor:Ipci M; Inci SB; Akyol Ardiç Ü; Ercan ES
[Ad] Endereço:Faculty of Art, Ege University, Izmir, Turkey melis.ipci@hotmail.com Institute on Drug Abuse, Toxicology and Pharmaceutical Science, Ege University, Izmir, Turkey Hospital for Psychiatry, Denizli, Turkey Medical Faculty, Child and Adolescent Psychiatry Department, Ege University, Izmir, Turkey.
[Ti] Título:A Case of Asperger Syndrome With Comorbidity of Posttraumatic Stress Disorder and Selective Mutism: Significant Remission With the Combination of Aripiprazole and Eye Movement Desensitization and Reprocessing.
[So] Source:J Clin Psychopharmacol;37(1):109-110, 2017 Feb.
[Is] ISSN:1533-712X
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Antipsicóticos/farmacologia
Aripiprazol/farmacologia
Síndrome de Asperger/terapia
Dessensibilização e Reprocessamento através dos Movimentos Oculares/métodos
Mutismo/terapia
Transtornos de Estresse Pós-Traumáticos/terapia
[Mh] Termos MeSH secundário: Antipsicóticos/administração & dosagem
Aripiprazol/administração & dosagem
Síndrome de Asperger/epidemiologia
Criança
Terapia Combinada
Comorbidade
Seres Humanos
Masculino
Mutismo/epidemiologia
Transtornos de Estresse Pós-Traumáticos/epidemiologia
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (Antipsychotic Agents); 82VFR53I78 (Aripiprazole)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161216
[St] Status:MEDLINE
[do] DOI:10.1097/JCP.0000000000000627


  6 / 931 MEDLINE  
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[PMID]:27787875
[Au] Autor:Lanier JC; Abrams AN
[Ad] Endereço:Department of Child and Adolescent Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
[Ti] Título:Posterior fossa syndrome: Review of the behavioral and emotional aspects in pediatric cancer patients.
[So] Source:Cancer;123(4):551-559, 2017 Feb 15.
[Is] ISSN:1097-0142
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Medulloblastoma, the most common malignant brain tumor of childhood, occurs in the posterior fossa, the part of the intracranial cavity that contains the brainstem and the cerebellum. The cerebellum is involved in many complex aspects of human behavior and function, and when it is disrupted or insulted, this can lead to significant sequelae in children with posterior fossa tumors. A constellation of impairing and distressing symptoms, including mutism, ataxia/hypotonia, and emotional lability, develops in approximately 25% of children after the surgical resection of posterior fossa tumors. These symptoms may impede treatment and frequently require intervention in order for children to be able to participate in their care. The eventual recovery of speech occurs for most, but with slowly improving dysarthria over many months. Behavioral changes and emotional lability also occur. This phenomenon has been classified differently by different investigators over the past 35 years. For the purposes of this article, the term posterior fossa syndrome is used to refer to the neuropsychiatric and behavioral features that compose this condition. The current review summarizes the development of the clinical understanding of this phenomenon with a focus on near- and long-term psychosocial and psychiatric implications. Also, clinical examples of the presentation, management, and lasting implications of this syndrome are provided. This review is intended to be a resource for clinicians who treat affected children. Cancer 2017;123:551-559. © 2016 American Cancer Society.
[Mh] Termos MeSH primário: Neoplasias Cerebelares/fisiopatologia
Neoplasias Infratentoriais/fisiopatologia
Meduloblastoma/fisiopatologia
Complicações Pós-Operatórias/fisiopatologia
[Mh] Termos MeSH secundário: Neoplasias Cerebelares/complicações
Neoplasias Cerebelares/psicologia
Neoplasias Cerebelares/cirurgia
Criança
Seres Humanos
Neoplasias Infratentoriais/complicações
Neoplasias Infratentoriais/psicologia
Neoplasias Infratentoriais/cirurgia
Meduloblastoma/complicações
Meduloblastoma/psicologia
Meduloblastoma/cirurgia
Mutismo/complicações
Mutismo/fisiopatologia
Complicações Pós-Operatórias/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170602
[Lr] Data última revisão:
170602
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161028
[St] Status:MEDLINE
[do] DOI:10.1002/cncr.30238


  7 / 931 MEDLINE  
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[PMID]:26940121
[Au] Autor:Klein ER; Armstrong SL; Skira K; Gordon J
[Ad] Endereço:1 Department of Communication Sciences and Disorders, La Salle University, USA.
[Ti] Título:Social Communication Anxiety Treatment (S-CAT) for children and families with selective mutism: A pilot study.
[So] Source:Clin Child Psychol Psychiatry;22(1):90-108, 2017 Jan.
[Is] ISSN:1461-7021
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This research assessed the feasibility of Social Communication Anxiety Treatment (S-CAT) developed by Elisa Shipon-Blum, a brief multimodal approach, to increase social communication in 40 children aged 5-12 years with selective mutism (SM). SM is a disorder in which children consistently fail to speak in specific situations although they have the ability to do so. Key features of this approach are the SM-Social Communication Comfort Scale (SCCS), transfer of control (ToC), a nonchalant therapeutic style, and cognitive-behavioral strategies over a brief time frame. Following 9 weeks of treatment, children showed significant gains in speaking frequency on all 17 items from the Selective Mutism Questionnaire (SMQ), a standardized measure of SM severity. Children also showed decreased levels of anxiety and withdrawal as reported by parents on the Child Behavior Checklist (CBCL). SM initial symptom severity and family therapy compliance, but not duration of SM, contributed to treatment outcomes.
[Mh] Termos MeSH primário: Ansiedade/terapia
Terapia Cognitiva/métodos
Comunicação
Terapia Familiar/métodos
Mutismo/terapia
Comportamento Social
[Mh] Termos MeSH secundário: Ansiedade/psicologia
Criança
Pré-Escolar
Feminino
Seres Humanos
Masculino
Mutismo/psicologia
Projetos Piloto
Relações Profissional-Paciente
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170214
[Lr] Data última revisão:
170214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160305
[St] Status:MEDLINE
[do] DOI:10.1177/1359104516633497


  8 / 931 MEDLINE  
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[PMID]:27686206
[Au] Autor:Engan M; Bjørlykke JA; Moen G; Lund KB; Njølstad G
[Ad] Endereço:Barneklinikken Haukeland universitetssykehus.
[Ti] Título:[A 4-year-old girl with diarrhoea, paresis and mutism].
[Ti] Título:En fire år gammel jente med diaré, kraftsvikt og mutisme..
[So] Source:Tidsskr Nor Laegeforen;136(17):1458-60, 2016 Sep.
[Is] ISSN:0807-7096
[Cp] País de publicação:Norway
[La] Idioma:nor
[Ab] Resumo:BACKGROUND Rotavirus is a common cause of gastroenteritis in children. Neurological manifestations associated with rotavirus infections are well described and range from benign afebrile convulsions to lethal encephalopathy or encephalitis.CASE PRESENTATION We present an uncommon neurological manifestation in a Caucasian child in the course of a rotavirus infection. A 4-year old girl presented with mutism, hypotonia and reduced consciousness. Magnetic resonance imaging revealed diffusion abnormalities in the splenium corpus callosum and bilaterally in the nuclei dentate in the cerebellum. She was diagnosed with rotavirus cerebellitis.INTERPRETATION Her clinical symptoms and the magnetic resonance imaging abnormalities were uncommon and previously described in only a few Caucasian children. The outcome has varied, and some children have shown long term neurological sequela. Treatment with immunoglobulins and corticosteroids has been used in similar cases, but there is no established treatment for this condition.
[Mh] Termos MeSH primário: Doenças Cerebelares/virologia
Infecções por Rotavirus/diagnóstico
[Mh] Termos MeSH secundário: Doenças Cerebelares/tratamento farmacológico
Pré-Escolar
Diarreia/virologia
Imagem de Difusão por Ressonância Magnética
Feminino
Seres Humanos
Mutismo/virologia
Paresia/virologia
Rotavirus/isolamento & purificação
Infecções por Rotavirus/complicações
Infecções por Rotavirus/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161001
[St] Status:MEDLINE
[do] DOI:10.4045/tidsskr.16.0070


  9 / 931 MEDLINE  
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[PMID]:27646053
[Au] Autor:Mehrzad R; Ho MG
[Ad] Endereço:Yale New Haven Hospital, Yale School of Medicine, New Haven, Connecticut.
[Ti] Título:Mutism Caused by Severe Demyelination in a Patient With Marchiafava-Bignami Disease.
[So] Source:J Emerg Med;51(6):e129-e132, 2016 Dec.
[Is] ISSN:0736-4679
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Marchiafava-Bignami (MB) disease is a rare disorder that causes primary degeneration of the corpus callosum. It is associated with chronic alcohol consumption caused by either a toxic or nutritional etiology. CASE REPORT: We report a case of a 54-year-old woman who presented to our emergency department with complete mutism caused by MB disease that completely resolved with intravenous thiamine and dextrose therapy. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Emergency physicians frequently encounter patients with alcohol abuse and its complications. We report a rare presentation of a potential alcohol-related spectrum disease that may be encountered by an emergency physician. Early diagnosis and prompt management are critical to potentially reversing the disease, and this case shows the importance of including this disease in the differential diagnosis in patients with speech difficulty and alcohol abuse.
[Mh] Termos MeSH primário: Alcoolismo/complicações
Doença de Marchiafava-Bignami/complicações
Mutismo/tratamento farmacológico
Mutismo/etiologia
Tiamina/uso terapêutico
Complexo Vitamínico B/uso terapêutico
[Mh] Termos MeSH secundário: Feminino
Derivação Gástrica/efeitos adversos
Glucose/uso terapêutico
Seres Humanos
Imagem por Ressonância Magnética
Doença de Marchiafava-Bignami/diagnóstico por imagem
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
12001-76-2 (Vitamin B Complex); IY9XDZ35W2 (Glucose); X66NSO3N35 (Thiamine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160921
[St] Status:MEDLINE


  10 / 931 MEDLINE  
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[PMID]:27508430
[Au] Autor:Hirakawa H; Terao T; Tanaka T; Sato H; Yoshimura R
[Ad] Endereço:Department of Neuropsychiatry, Faculty of Medicine, Oita University, Oita, Japan; Department of Psychiatry, Faculty of Medicine, University of Occupational and Environmental Health, Japan; and Department of Forensic Medicine, School of Medicine, University of Occupational and Environmental Health, Japan hiro-hira@oita-u.ac.jp.
[Ti] Título:A Case of Mutism in Noncatatonic Schizophrenia Responding to Small Dose of Fluvoxamine Addition to Clozapine.
[So] Source:J Clin Psychopharmacol;36(5):531-2, 2016 Oct.
[Is] ISSN:1533-712X
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Antipsicóticos/farmacologia
Clozapina/farmacologia
Inibidores das Enzimas do Citocromo P-450/farmacologia
Fluvoxamina/farmacologia
Mutismo/tratamento farmacológico
Esquizofrenia/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Antipsicóticos/administração & dosagem
Clozapina/administração & dosagem
Inibidores das Enzimas do Citocromo P-450/administração & dosagem
Quimioterapia Combinada
Fluvoxamina/administração & dosagem
Seres Humanos
Masculino
Mutismo/etiologia
Esquizofrenia/complicações
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (Antipsychotic Agents); 0 (Cytochrome P-450 Enzyme Inhibitors); J60AR2IKIC (Clozapine); O4L1XPO44W (Fluvoxamine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160811
[St] Status:MEDLINE
[do] DOI:10.1097/JCP.0000000000000552



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde