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Pesquisa : C10.597.606.358.800.200.200 [Categoria DeCS]
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  1 / 97 MEDLINE  
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[PMID]:25742590
[Au] Autor:Aguiar TS; Maranhão-Filho P
[Ad] Endereço:Departamento de Neurologia, Hospital Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
[Ti] Título:The corneomandibular reflex: a light touch and wide conclusions.
[So] Source:Arq Neuropsiquiatr;73(2):170, 2015 Feb.
[Is] ISSN:1678-4227
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Mh] Termos MeSH primário: Coma Pós-Traumatismo da Cabeça/fisiopatologia
Córnea/fisiopatologia
Mandíbula/fisiopatologia
Reflexo Anormal/fisiologia
[Mh] Termos MeSH secundário: Seres Humanos
Masculino
Meia-Idade
Tato
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1507
[Cu] Atualização por classe:150306
[Lr] Data última revisão:
150306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150306
[St] Status:MEDLINE


  2 / 97 MEDLINE  
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[PMID]:25664378
[Au] Autor:Lei J; Wang L; Gao G; Cooper E; Jiang J
[Ad] Endereço:1 Department of Neurosurgery, Renji Hospital, Shanghai Jiaotong University School of Medicine , Shanghai, China .
[Ti] Título:Right Median Nerve Electrical Stimulation for Acute Traumatic Coma Patients.
[So] Source:J Neurotrauma;32(20):1584-9, 2015 Oct 15.
[Is] ISSN:1557-9042
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The right median nerve as a peripheral portal to the central nervous system can be electrically stimulated to help coma arousal after traumatic brain injury (TBI). The present study set out to examine the efficacy and safety of right median nerve electrical stimulation (RMNS) in a cohort of 437 comatose patients after severe TBI from August 2005 to December 2011. The patients were enrolled 2 weeks after their injury and assigned to the RMNS group (n=221) receiving electrical stimulation for 2 weeks or the control group (n = 216) treated by standard management according to the date of birth in the month. The baseline data were similar. After the 2-week treatment, the RMNS-treated patients demonstrated a more rapid increase of the mean Glasgow Coma Score, although statistical significance was not reached (8.43 ± 4.98 vs. 7.47 ± 5.37, p = 0.0532). The follow-up data at 6-month post-injury showed a significantly higher proportion of patients who regained consciousness (59.8% vs. 46.2%, p = 0.0073). There was a lower proportion of vegetative persons in the RMNS group than in the control group (17.6% vs. 22.0%, p = 0.0012). For persons regaining consciousness, the functional independence measurement (FIM) score was higher among the RMNS group patients (91.45 ± 8.65 vs. 76.23 ± 11.02, p < 0.001). There were no unique complications associated with the RMNS treatment. The current study, although with some limitations, showed that RMNS may serve as an easy, effective, and noninvasive technique to promote the recovery of traumatic coma in the early phase.
[Mh] Termos MeSH primário: Lesões Encefálicas/complicações
Coma Pós-Traumatismo da Cabeça/terapia
Terapia por Estimulação Elétrica/métodos
Nervo Mediano
[Mh] Termos MeSH secundário: Adulto
Coma Pós-Traumatismo da Cabeça/etiologia
Terapia por Estimulação Elétrica/efeitos adversos
Feminino
Seguimentos
Escala de Coma de Glasgow
Seres Humanos
Masculino
Meia-Idade
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1607
[Cu] Atualização por classe:151006
[Lr] Data última revisão:
151006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150210
[St] Status:MEDLINE
[do] DOI:10.1089/neu.2014.3768


  3 / 97 MEDLINE  
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[PMID]:25381459
[Au] Autor:Schorr B; Schlee W; Arndt M; Lulé D; Kolassa IT; Lopez-Rolon A; Lopez-Rolon A; Bender A
[Ad] Endereço:Therapiezentrum Burgau, Kapuzinerstraße 34, 89331, Burgau, Germany, barbara.schorr@uni-ulm.de.
[Ti] Título:Stability of auditory event-related potentials in coma research.
[So] Source:J Neurol;262(2):307-15, 2015 Feb.
[Is] ISSN:1432-1459
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Patients with unresponsive wakefulness syndrome (UWS) or in minimally conscious state (MCS) after brain injury show significant fluctuations in their behavioural abilities over time. As the importance of event-related potentials (ERPs) in the detection of traces of consciousness increases, we investigated the retest reliability of ERPs with repeated tests at four different time points. Twelve healthy controls and 12 inpatients (8 UWS, 4 MCS; 6 traumatic, 6 non-traumatic) were tested twice a day (morning, afternoon) for 2 days with an auditory oddball task. ERPs were recorded with a 256-channel-EEG system, and correlated with behavioural test scores in the Coma Recovery Scale-revised (CRS-R). The number of identifiable P300 responses varied between zero and four in both groups. Reliabilities varied between Krippendorff's α = 0.43 for within-day comparison, and α = 0.25 for between-day comparison in the patient group. Retest reliability was strong for the CRS-R scores for all comparisons (α = 0.83-0.95). The stability of auditory information processing in patients with disorders of consciousness is the basis for other, even more demanding tasks and cognitive potentials. The relatively low ERP-retest reliability suggests that it is necessary to perform repeated tests, especially when probing for consciousness with ERPs. A single negative ERP test result may be mistaken for proof that a UWS patient truly is unresponsive.
[Mh] Termos MeSH primário: Coma Pós-Traumatismo da Cabeça/fisiopatologia
Potencial Evocado P300/fisiologia
Potenciais Evocados Auditivos/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Reprodutibilidade dos Testes
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1512
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141110
[St] Status:MEDLINE
[do] DOI:10.1007/s00415-014-7561-y


  4 / 97 MEDLINE  
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[PMID]:25233298
[Au] Autor:Suehiro E; Koizumi H; Fujisawa H; Fujita M; Kaneko T; Oda Y; Yamashita S; Tsuruta R; Maekawa T; Suzuki M
[Ad] Endereço:1 Department of Neurosurgery, Yamaguchi University School of Medicine , Ube, Yamaguchi, Japan .
[Ti] Título:Diverse effects of hypothermia therapy in patients with severe traumatic brain injury based on the computed tomography classification of the traumatic coma data bank.
[So] Source:J Neurotrauma;32(5):353-8, 2015 Mar 01.
[Is] ISSN:1557-9042
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A multicenter randomized controlled trial of patients with severe traumatic brain injury who received therapeutic hypothermia or fever control was performed from 2002 to 2008 in Japan (BHYPO). There was no difference in the therapeutic effect on traumatic brain injury between the two groups. The efficacy of hypothermia treatment and the objective of the treatment were reexamined based on a secondary analysis of the BHYPO trial in 135 patients (88 treated with therapeutic hypothermia and 47 with fever control). This analysis was performed to examine clinical outcomes according to the CT classification of the Traumatic Coma Data Bank on admission. Clinical outcomes were evaluated with the Glasgow Outcome Scale and mortality at 6 months after injury. Good recovery and moderate disability were defined as favorable outcomes. Favorable outcomes in young patients (≤50 years old) with evacuated mass lesions significantly increased from 33.3% with fever control to 77.8% with therapeutic hypothermia. Patients with diffuse injury III who were treated with therapeutic hypothermia, however, had significantly higher mortality than patients treated with fever control. It was difficult to control intracranial pressure with hypothermia for patients with diffuse injury III, but hypothermia was effective for young patients with an evacuated mass lesion.
[Mh] Termos MeSH primário: Lesões Encefálicas/terapia
Coma Pós-Traumatismo da Cabeça/terapia
Hipotermia Induzida/métodos
[Mh] Termos MeSH secundário: Adulto
Lesões Encefálicas/classificação
Lesões Encefálicas/diagnóstico por imagem
Coma Pós-Traumatismo da Cabeça/classificação
Coma Pós-Traumatismo da Cabeça/diagnóstico por imagem
Feminino
Escala de Resultado de Glasgow
Seres Humanos
Masculino
Meia-Idade
Recuperação de Função Fisiológica
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1511
[Cu] Atualização por classe:161215
[Lr] Data última revisão:
161215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140919
[St] Status:MEDLINE
[do] DOI:10.1089/neu.2014.3584


  5 / 97 MEDLINE  
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[PMID]:25473741
[Au] Autor:Bagnato S; Boccagni C; Sant'Angelo A; Fingelkurts AA; Fingelkurts AA; Gagliardo C; Galardi G
[Ti] Título:Long-lasting coma.
[So] Source:Funct Neurol;29(3):201-5, 2014 Jul-Sep.
[Is] ISSN:1971-3274
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:In this report, we describe the case of a patient who has remained in a comatose state for more than one year after a traumatic and hypoxic brain injury. This state, which we refer to as long-lasting coma (LLC), may be a disorder of consciousness with significantly different features from those of conventional coma, the vegetative state, or brain death. On the basis of clinical, neurophysiological and neuroimaging data, we hypothesize that a multilevel involvement of the ascending reticular activating system is required in LLC. This description may be useful for the identification of other patients suffering from this severe disorder of consciousness, which raises important ethical issues.
[Mh] Termos MeSH primário: Encéfalo/patologia
Encéfalo/fisiopatologia
Coma Pós-Traumatismo da Cabeça/diagnóstico
[Mh] Termos MeSH secundário: Encéfalo/metabolismo
Coma Pós-Traumatismo da Cabeça/etiologia
Eletroencefalografia
Glucose/metabolismo
Seres Humanos
Hipóxia Encefálica/complicações
Masculino
Meia-Idade
Fatores de Tempo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141205
[St] Status:MEDLINE


  6 / 97 MEDLINE  
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[PMID]:25006909
[Au] Autor:Xin H; Yun S; Jun X; Liang W; Ye-Lin C; Xiao-Feng Y
[Ad] Endereço:From the Department of Neurosurgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
[Ti] Título:Long-term outcomes after shunt implantation in patients with posttraumatic hydrocephalus and severe conscious disturbance.
[So] Source:J Craniofac Surg;25(4):1280-3, 2014 Jul.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Posttraumatic hydrocephalus (PTH) is a frequent complication secondary to traumatic brain injury, especially among patients keeping chronic unconscious. And effects of shunt implantation on improving outcomes among these patients are still controversial. This study was aimed to assess the long-term outcomes following shunt implantation among patients who had PTH and kept chronic unconscious. METHODS: A prospective study was performed to include patients who had PTH and remained in severe conscious disturbance from March 2010 to December 2010. All of included patients would have shunt implantation and be closely followed up at least for 2 years to assess final outcomes. RESULTS: Fifteen patients having PTH were identified. Before shunt implantation, 2 patients kept vegetative state (Glasgow Outcome Scale [GOS] score 2), and 13 patients kept minimally consciousness with severe disability (GOS score 3). After shunt implantation, the shunt device was removed because of intracranial infection in 1 patient, and the other patient died because of allergic shock. Among the remaining 13 patients, finally 7 patients had improvement on GOS or Modified Barthel Index (MBI) score during the 2-year follow-up, but only 1 patient achieved a good outcome (GOS score 4, independent life). Among them, 5 patients' outcomes improved as assessed by GOS or MBI score during the first 3 months following shunt implantation. During the fourth to sixth month following shunt implantation, there were 2 patients who showed first rise on GOS or MBI score. Beyond 6 months, no patient showed initial improvement. And among patients who showed improvement, most of them kept improving during a certain time. CONCLUSIONS: A proportion of patients who had PTH and remained in severe conscious disturbance would benefit from shunt implantation, and the improvement may turn up late after this procedure.
[Mh] Termos MeSH primário: Derivações do Líquido Cefalorraquidiano
Coma Pós-Traumatismo da Cabeça/cirurgia
Sedação Consciente
Hidrocefalia/cirurgia
Complicações Pós-Operatórias/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Coma Pós-Traumatismo da Cabeça/diagnóstico
Feminino
Seguimentos
Escala de Resultado de Glasgow
Seres Humanos
Hidrocefalia/diagnóstico
Masculino
Meia-Idade
Complicações Pós-Operatórias/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1511
[Cu] Atualização por classe:140710
[Lr] Data última revisão:
140710
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:140710
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000000583


  7 / 97 MEDLINE  
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[PMID]:24761591
[Au] Autor:Potapov AA; Zakharova NE; Kornienko VN; Pronin IN; Alexandrova EV; Zaitsev OS; Likhterman LB; Gavrilov AG; Danilov GV; Oshorov AV; Sychev AA; Polupan AA
[Ti] Título:[Neuroanatomical basis for traumatic coma: clinical and magnetic resonance correlates].
[So] Source:Zh Vopr Neirokhir Im N N Burdenko;78(1):4-13; discussion 13, 2014.
[Is] ISSN:0042-8817
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:In this paper, the relationship between brain lesion localization (verified by magnetic resonance imaging (MRI)) and the severity of traumatic brain injury (TBI) and its outcomes is presented. Magnetic resonance studies in different modes (T1, T2, FLAIR, DWI, DTI, T2 * GRE, SWAN) were performed in 162 patients with acute TBI. Statistical analysis was done using Statistica 6, 8 software and R programming language. A new advanced MRI-based classification of TBI was introduced implying the assessment of hemispheric and brainstem traumatic lesions level and localization. Statistically significant correlations were found between the Glasgow coma and outcome scales scores (p < 0.001), and the proposed MRI grading scale scores, which means a high prognostic value of the new classification. The knowledge of injured brain microanatomy coming from sensitive neuroimaging, in conjunction with the assessment of mechanisms, aggravating factors and clinical manifestation of brain trauma is the basis for the actual predictive model of TBI. The proposed advanced MRI classification contributes to this concept development.
[Mh] Termos MeSH primário: Lesões Encefálicas/diagnóstico
Coma Pós-Traumatismo da Cabeça/diagnóstico
Imagem por Ressonância Magnética/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Lesões Encefálicas/classificação
Criança
Interpretação Estatística de Dados
Feminino
Escala de Coma de Glasgow
Seres Humanos
Interpretação de Imagem Assistida por Computador
Masculino
Meia-Idade
Prognóstico
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Mês de entrada:1407
[Cu] Atualização por classe:140425
[Lr] Data última revisão:
140425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140426
[St] Status:MEDLINE


  8 / 97 MEDLINE  
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[PMID]:24525702
[Au] Autor:Edlow BL; Kinney HC; Folkerth R
[Ad] Endereço:Harvard Medical School, Boston, Massachusetts.
[Ti] Título:Authors' reply.
[So] Source:J Neuropathol Exp Neurol;73(3):268-9, 2014 Mar.
[Is] ISSN:1554-6578
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Nível de Alerta
Tronco Encefálico/patologia
Coma Pós-Traumatismo da Cabeça/diagnóstico
Coma Pós-Traumatismo da Cabeça/fisiopatologia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
[Pt] Tipo de publicação:COMMENT; LETTER
[Em] Mês de entrada:1404
[Cu] Atualização por classe:140214
[Lr] Data última revisão:
140214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140215
[St] Status:MEDLINE
[do] DOI:10.1097/01.jnen.0000444376.51734.30


  9 / 97 MEDLINE  
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[PMID]:24487802
[Au] Autor:Rosenblum W
[Ad] Endereço:200 East End Ave., Apt 9i, New York, NY 10128.
[Ti] Título:Re: Disconnection of the ascending arousal system in traumatic coma. J Neuropathol Exp Neurol 2013;72: 505-523.
[So] Source:J Neuropathol Exp Neurol;73(3):268, 2014 Mar.
[Is] ISSN:1554-6578
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Nível de Alerta
Tronco Encefálico/patologia
Coma Pós-Traumatismo da Cabeça/diagnóstico
Coma Pós-Traumatismo da Cabeça/fisiopatologia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
[Pt] Tipo de publicação:COMMENT; LETTER
[Em] Mês de entrada:1404
[Cu] Atualização por classe:140214
[Lr] Data última revisão:
140214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140204
[St] Status:MEDLINE
[do] DOI:10.1097/NEN.0000000000000049


  10 / 97 MEDLINE  
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[PMID]:23881623
[Au] Autor:Edlow BL; Giacino JT; Wu O
[Ad] Endereço:Department of Neurology, Massachusetts General Hospital, 55 Fruit Street - Lunder 650, Boston, MA 02114, USA. bedlow@partners.org
[Ti] Título:Functional MRI and outcome in traumatic coma.
[So] Source:Curr Neurol Neurosci Rep;13(9):375, 2013 Sep.
[Is] ISSN:1534-6293
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Advances in task-based functional MRI (fMRI), resting-state fMRI (rs-fMRI), and arterial spin labeling (ASL) perfusion MRI have occurred at a rapid pace in recent years. These techniques for measuring brain function have great potential to improve the accuracy of prognostication for civilian and military patients with traumatic coma. In addition, fMRI, rs-fMRI, and ASL perfusion MRI have provided novel insights into the pathophysiology of traumatic disorders of consciousness, as well as the mechanisms of recovery from coma. However, functional neuroimaging techniques have yet to achieve widespread clinical use as prognostic tests for patients with traumatic coma. Rather, a broad spectrum of methodological hurdles currently limits the feasibility of clinical implementation. In this review, we discuss the basic principles of fMRI, rs-fMRI, and ASL perfusion MRI and their potential applications as prognostic tools for patients with traumatic coma. We also discuss future strategies for overcoming the current barriers to clinical implementation.
[Mh] Termos MeSH primário: Encéfalo/fisiopatologia
Coma Pós-Traumatismo da Cabeça/fisiopatologia
Imagem por Ressonância Magnética
[Mh] Termos MeSH secundário: Animais
Encéfalo/patologia
Coma Pós-Traumatismo da Cabeça/diagnóstico
Seres Humanos
Imagem por Ressonância Magnética/métodos
Perfusão/métodos
Prognóstico
Marcadores de Spin
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; REVIEW
[Nm] Nome de substância:
0 (Spin Labels)
[Em] Mês de entrada:1403
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130725
[St] Status:MEDLINE
[do] DOI:10.1007/s11910-013-0375-y



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