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[PMID]: 29339255 [Au] Autor: Sun G; Wang J; Guo X; Lei M; Zhang Y; Wang X; Shen X; Hu L [Ad] Endereço: Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 2100 [Ti] Título: Design, synthesis and biological evaluation of LX2343 derivatives as neuroprotective agents for the treatment of Alzheimer's disease. [So] Source: Eur J Med Chem;145:622-633, 2018 Feb 10. [Is] ISSN: 1768-3254 [Cp] País de publicação: France [La] Idioma: eng [Ab] Resumo: A series of LX2343 derivatives were designed, synthesized and evaluated as neuroprotective agents for Alzheimer's disease (AD) in vitro. Most of the compounds displayed potent neuroprotective activities. Especially for compound A6, exhibited a remarkable EC value of 0.22 µM. Further investigation demonstrated that compound A6 can significantly reduce Aß production and increase Aß clearance, and alleviate Tau hyperphosphorylation. Most importantly, compound A6 could ameliorate learning and memory impairments in APP/PS1 transgenic mice. The present study evidently showed that compound A6 is a potent neuroprotective agent and might serve as a promising lead candidate for the treatment of Alzheimer's disease. [Mh] Termos MeSH primário: Acetamidas/farmacologia Doença de Alzheimer/tratamento farmacológico Desenho de Drogas Fármacos Neuroprotetores/farmacologia Sulfonamidas/farmacologia [Mh] Termos MeSH secundário: Acetamidas/síntese química Acetamidas/química Peptídeos beta-Amiloides/antagonistas & inibidores Peptídeos beta-Amiloides/metabolismo Animais Relação Dose-Resposta a Droga Células HEK293 Seres Humanos Aprendizagem em Labirinto/efeitos dos fármacos Transtornos da Memória/tratamento farmacológico Camundongos Camundongos Transgênicos Estrutura Molecular Fármacos Neuroprotetores/síntese química Fármacos Neuroprotetores/química Relação Estrutura-Atividade Sulfonamidas/síntese química Sulfonamidas/química Células Tumorais Cultivadas [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Acetamides); 0 (Amyloid beta-Peptides); 0 (LX2343); 0 (Neuroprotective Agents); 0 (Sulfonamides) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180302 [Lr] Data última revisão: 180302 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180118 [St] Status: MEDLINE

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[PMID]: 29314866 [Au] Autor: Herrlinger KA; Nieman KM; Sanoshy KD; Fonseca BA; Lasrado JA; Schild AL; Maki KC; Wesnes KA; Ceddia MA [Ad] Endereço: 1 Kemin Foods, LC , Des Moines, IA. [Ti] Título: Spearmint Extract Improves Working Memory in Men and Women with Age-Associated Memory Impairment. [So] Source: J Altern Complement Med;24(1):37-47, 2018 Jan. [Is] ISSN: 1557-7708 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVE: The purpose of this study was to investigate the effects of supplementation with a spearmint (Mentha spicata L.) extract, high in polyphenols including rosmarinic acid, on cognitive performance, sleep, and mood in individuals with age-associated memory impairment (AAMI). DESIGN: Subjects with AAMI (N = 90; 67% female; age = 59.4 ± 0.6 years) were randomly assigned (n = 30/group) to consume 900, 600, or 0 mg/day (two capsules, once daily) spearmint extract for 90 days, in this double-blind, placebo-controlled trial. Assessments were completed for cognition (days 0, 45, and 90), sleep (days 0 and 90), and mood (days 0 and 90) by using the Cognitive Drug Research (CDR) System , Leeds Sleep Evaluation Questionnaire (LSEQ), and Profile of Mood States (POMS ), respectively. RESULTS: Quality of working memory and spatial working memory accuracy improved after supplementation with 900 mg/day spearmint extract by 15% (p = 0.0469) and 9% (p = 0.0456), respectively, versus placebo. Subjects consuming 900 mg/day spearmint extract reported improvement in their ability to fall asleep, relative to subjects consuming placebo (p = 0.0046). Overall treatment effects were evident for vigor-activity (p = 0.0399), total mood disturbance (p = 0.0374), and alertness and behavior following wakefulness (p = 0.0415), with trends observed for improvements after spearmint supplementation relative to placebo. CONCLUSIONS: These results suggest that the distinct spearmint extract may be a beneficial nutritional intervention for cognitive health in older subjects with AAMI. [Mh] Termos MeSH primário: Transtornos da Memória/tratamento farmacológico Memória de Curto Prazo/efeitos dos fármacos Extratos Vegetais/farmacologia Extratos Vegetais/uso terapêutico [Mh] Termos MeSH secundário: Cinamatos Cognição/efeitos dos fármacos Depsídeos Feminino Seres Humanos Masculino Mentha spicata Meia-Idade Polifenóis Sono/efeitos dos fármacos [Pt] Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Nm] Nome de substância: 0 (Cinnamates); 0 (Depsides); 0 (Plant Extracts); 0 (Polyphenols); MQE6XG29YI (rosmarinic acid) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180223 [Lr] Data última revisão: 180223 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180110 [St] Status: MEDLINE [do] DOI: 10.1089/acm.2016.0379

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[PMID]: 29390491 [Au] Autor: Jang SH; Seo JP [Ad] Endereço: Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daemyungdong, Namku, Taegu, Republic of Korea. [Ti] Título: Absent-mindedness and injury of the ascending reticular activating system in a patient with mild traumatic brain injury: A case report. [So] Source: Medicine (Baltimore);96(51):e9289, 2017 Dec. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE: No study on the association of absent-mindedness and injury of the ascending reticular activating system (ARAS) has been reported. We report on a patient who showed absent-mindedness and injury of the ARAS following mild traumatic brain injury. PATIENT CONCERNS: The patient complained of absent-mindedness since the head trauma, which was mainly observed while dining for several (5-10) minutes approximately 3 to 4 times a day: according to the patient's family, he usually stopped eating while holding the spoon in the air for approximately 5∼10 minutes. DIAGNOSES: A 19-year-old man suffered from head trauma resulting from being hit on his head by a falling glass from a large window (1.5 × 2 m, approximately 100 kg) at a cafe. INTERVENTIONS: His absent-mindedness showed slow improvement with the passage of time and had almost disappeared at seven months after onset. OUTCOMES: The lower portion of both lower dorsal ARAS and the upper portion of the left lower ventral ARAS of the patient were thinner, and partial tearing was observed in the right lower ventral ARAS. Decreased neural connectivity of the intralaminar thalamic nucleus to the prefrontal cortex, basal forebrain, parietal cortex, and occipital cortex was detected in both hemispheres. LESSONS: Injury of the ARAS and injury of the cerebral cortex was demonstrated in a patient with absent-mindedness following mild traumatic brain injury. The absent-mindedness in this patient might be related to the injury of the ARAS. [Mh] Termos MeSH primário: Concussão Encefálica/complicações Traumatismos Craniocerebrais/complicações Núcleos Intralaminares do Tálamo/lesões Transtornos da Memória/etiologia [Mh] Termos MeSH secundário: Concussão Encefálica/diagnóstico Córtex Cerebral/lesões Traumatismos Craniocerebrais/diagnóstico por imagem Seguimentos Seres Humanos Escala de Gravidade do Ferimento Masculino Transtornos da Memória/fisiopatologia Testes Neuropsicológicos Índice de Gravidade de Doença Fatores de Tempo Tomografia Computadorizada de Emissão de Fóton Único/métodos Adulto Jovem [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180214 [Lr] Data última revisão: 180214 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180203 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000009289

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[PMID]: 29390470 [Au] Autor: Jang SH; Seo JP [Ad] Endereço: Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daemyungdong, Namgu, Daegu, Republic of Korea. [Ti] Título: Delayed degeneration of the left fornical crus with verbal memory impairment in a patient with mild traumatic brain injury: A case report. [So] Source: Medicine (Baltimore);96(51):e9219, 2017 Dec. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE: We report on a patient who showed delayed degeneration of the left fornical crus with verbal memory impairment following mild traumatic brain injury (TBI), which was demonstrated by diffusion tensor tractography (DTT). PATIENT CONCERNS:: fter flexion and hyperextension of her head to the opposite side, the patient experienced a dazed feeling for a while at the time of head trauma. The patient's Glasgow Coma Scale score was 15, and mini-mental state examination score was 30. DIAGNOSES: A 50-year-old right-handed female with 12 years of education suffered from head trauma resulting from a car accident. INTERVENTIONS: A The patient showed normal memory function at one year after onset: the Memory Assessment Scale (global memory: 124 (95 percentile (%ile)), verbal memory: 111 (77%ile), and visual memory: 132 (98%ile) (A percentile is a measure used in statistics indicating the value below which a given percentage of observations in a group of observations fall). However, the patient began to experience decline of memory function such as forgetfulness at approximately 1.5 years after onset. On the 2-year evaluation, she showed decrement of memory function (global memory: 108 (70%ile), verbal memory: 86 (18%ile), and visual memory: 129 (97%ile). OUTCOMES: On 1-year DTT, the integrity of the fornix was well preserved between the fornical column and fornical crus. However, on 2-year DTT, a discontinuation was observed in the left fornical crus. LESSONS: Delayed degeneration of the left fornical crus was demonstrated in a patient who showed delayed onset of verbal memory impairment following mild TBI. [Mh] Termos MeSH primário: Concussão Encefálica/complicações Imagem de Tensor de Difusão/métodos Fórnice/diagnóstico por imagem Fórnice/fisiopatologia Transtornos da Memória/etiologia [Mh] Termos MeSH secundário: Acidentes de Trânsito Concussão Encefálica/diagnóstico Progressão da Doença Feminino Seguimentos Fórnice/lesões Escala de Coma de Glasgow Seres Humanos Imagem por Ressonância Magnética/métodos Transtornos da Memória/fisiopatologia Meia-Idade Testes Neuropsicológicos República da Coreia Medição de Risco Fatores de Tempo Comportamento Verbal [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180214 [Lr] Data última revisão: 180214 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180203 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000009219

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[PMID]: 29329293 [Au] Autor: Ezeamama AE; Bustinduy AL; Nkwata AK; Martinez L; Pabalan N; Boivin MJ; King CH [Ad] Endereço: Department of Psychiatry, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, United States of America. [Ti] Título: Cognitive deficits and educational loss in children with schistosome infection-A systematic review and meta-analysis. [So] Source: PLoS Negl Trop Dis;12(1):e0005524, 2018 01. [Is] ISSN: 1935-2735 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: By means of meta-analysis of information from all relevant epidemiologic studies, we examined the hypothesis that Schistosoma infection in school-aged children (SAC) is associated with educational loss and cognitive deficits. METHODOLOGY/PRINCIPAL FINDINGS: This review was prospectively registered in the PROSPERO database (CRD42016040052). Medline, Biosis, and Web of Science were searched for studies published before August 2016 that evaluated associations between Schistosoma infection and cognitive or educational outcomes. Cognitive function was defined in four domains-learning, memory, reaction time, and innate intelligence. Educational outcome measures were defined as attendance and scholastic achievement. Risk of bias (ROB) was evaluated using the Newcastle-Ottawa quality assessment scale. Standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated to compare cognitive and educational measures for Schistosoma infected /not dewormed vs. uninfected/dewormed children. Sensitivity analyses by study design, ROB, and sequential exclusion of individual studies were implemented. Thirty studies from 14 countries, including 38,992 SAC between 5-19 years old, were identified. Compared to uninfected children and children dewormed with praziquantel, the presence of Schistosoma infection and/or non-dewormed status was associated with deficits in school attendance (SMD = -0.36, 95%CI: -0.60, -0.12), scholastic achievement (SMD = -0.58, 95%CI: -0.96, -0.20), learning (SMD = -0.39, 95%CI: -0.70, -0.09) and memory (SMD = -0.28, 95%CI: -0.52, -0.04) tests. By contrast, Schistosoma-infected/non-dewormed and uninfected/dewormed children were similar with respect to performance in tests of reaction time (SMD = -0.06, 95%CI: -0.42, 0.30) and intelligence (SMD = -0.25, 95%CI: -0.57, 0.06). Schistosoma infection-associated deficits in educational measures were robust among observational studies, but not among interventional studies. The significance of infection-associated deficits in scholastic achievement was sensitive to ROB. Schistosoma infection-related deficits in learning and memory tests were invariant by ROB and study design. CONCLUSION/SIGNIFICANCE: Schistosoma infection/non-treatment was significantly associated with educational, learning, and memory deficits in SAC. Early treatment of children in Schistosoma-endemic regions could potentially mitigate these deficits. TRIAL REGISTRATION: ClinicalTrials.gov CRD42016040052. [Mh] Termos MeSH primário: Disfunção Cognitiva/parasitologia Transtornos de Aprendizagem/parasitologia Transtornos da Memória/parasitologia Esquistossomose/complicações [Mh] Termos MeSH secundário: Adolescente Animais Anti-Helmínticos/uso terapêutico Criança Pré-Escolar Cognição/fisiologia Seres Humanos Inteligência/fisiologia Memória/fisiologia Testes de Memória e Aprendizagem Praziquantel/uso terapêutico Tempo de Reação/fisiologia Schistosoma/patogenicidade Esquistossomose/tratamento farmacológico Esquistossomose/psicologia [Pt] Tipo de publicação: JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW [Nm] Nome de substância: 0 (Anthelmintics); 6490C9U457 (Praziquantel) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180210 [Lr] Data última revisão: 180210 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180113 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pntd.0005524

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[PMID]: 28460850 [Au] Autor: Hu X; Heyn PC; Schwartz J; Roberts P [Ti] Título: What Is Mild Stroke? [So] Source: Arch Phys Med Rehabil;98(11):2347-2349, 2017 Nov. [Is] ISSN: 1532-821X [Cp] País de publicação: United States [La] Idioma: eng [Mh] Termos MeSH primário: Acidente Vascular Cerebral/complicações [Mh] Termos MeSH secundário: Emoções Fadiga/etiologia Seres Humanos Hipestesia/etiologia Transtornos da Memória/etiologia Debilidade Muscular/etiologia Índice de Gravidade de Doença Acidente Vascular Cerebral/diagnóstico Acidente Vascular Cerebral/psicologia Avaliação de Sintomas [Pt] Tipo de publicação: JOURNAL ARTICLE; PATIENT EDUCATION HANDOUT [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180209 [Lr] Data última revisão: 180209 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170503 [St] Status: MEDLINE

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[PMID]: 28987617 [Au] Autor: Goodfellow MJ; Shin YJ; Lindquist DH [Ad] Endereço: Department of Psychology, The Ohio State University, 1835 Neil Ave., Columbus, OH 43210, USA. Electronic address: mgoodfellow@som.umaryland.edu. [Ti] Título: Mitigation of postnatal ethanol-induced neuroinflammation ameliorates trace fear memory deficits in juvenile rats. [So] Source: Behav Brain Res;338:28-31, 2018 Feb 15. [Is] ISSN: 1872-7549 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Impairments in behavior and cognition are common in individuals diagnosed with fetal alcohol spectrum disorders (FASD). In this study, FASD model rats were intragastrically intubated with ethanol (5g/kg/day; 5E), sham-intubated (SI), or maintained as naïve controls (NC) over postnatal days (PD) 4-9. Ethanol exposure during this human third trimester-equivalent period induces persistent impairments in hippocampus-dependent learning and memory. The ability of ibuprofen (IBU), a non-steroidal anti-inflammatory drug, to diminish ethanol-induced neuroinflammation and rescue deficits in hippocampus-dependent trace fear conditioning (TFC) was investigated in 5E rats. Phosphate buffered saline vehicle (VEH) or IBU was injected 2h following ethanol exposure over PD4-9, followed by quantification of inflammation-related genes in the dorsal hippocampus of PD10 rats. The 5E-VEH rats exhibited significant increases in Il1b and Tnf, but not Itgam or Gfap, relative to NC, SI-VEH, and 5E-IBU rats. In separate groups of PD31-33 rats, conditioned fear (freezing) was significantly reduced in 5E-VEH rats during TFC testing, but not acquisition, compared to SI-VEH and, critically, 5E-IBU rats. Results suggest neuroimmune activation in response to ethanol within the neonate hippocampus contributes to later-life cognitive dysfunction. [Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/uso terapêutico Encéfalo/efeitos dos fármacos Citocinas/metabolismo Etanol/administração & dosagem Transtornos do Espectro Alcoólico Fetal/metabolismo Ibuprofeno/uso terapêutico Transtornos da Memória/tratamento farmacológico [Mh] Termos MeSH secundário: Animais Encéfalo/metabolismo Condicionamento (Psicologia)/efeitos dos fármacos Condicionamento (Psicologia)/fisiologia Citocinas/genética Modelos Animais de Doenças Medo/efeitos dos fármacos Medo/fisiologia Hipocampo/efeitos dos fármacos Hipocampo/metabolismo Transtornos da Memória/metabolismo Ratos Ratos Long-Evans [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Cytokines); 3K9958V90M (Ethanol); WK2XYI10QM (Ibuprofen) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180207 [Lr] Data última revisão: 180207 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171009 [St] Status: MEDLINE

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[PMID]: 29236820 [Au] Autor: Resende EPF; Tovar-Moll FF; Ferreira FM; Bramati I; de Souza LC; Carmona KC; Guimarães HC; Carvalho VA; Barbosa MT; Caramelli P [Ad] Endereço: Universidade Federal de Minas Gerais, Faculdade de Medicina da Belo Horizonte, Departamento de Clínica Médica, Grupo de Pesquisa em Neurologia Cognitiva e do Comportamento, Belo Horizonte MG, Brasil. [Ti] Título: Integrity of white matter structure is related to episodic memory performance in the low-educated elderly. [So] Source: Arq Neuropsiquiatr;75(11):778-784, 2017 11. [Is] ISSN: 1678-4227 [Cp] País de publicação: Brazil [La] Idioma: eng [Ab] Resumo: The low-educated elderly are a vulnerable population in whom studying the role of white matter integrity on memory may provide insights for understanding how memory declines with aging and disease. METHODS: Thirty-one participants (22 women), 23 cognitively healthy and eight with cognitive impairment-no dementia, aged 80.4 ± 3.8 years, with 2.2 ± 1.9 years of education, underwent an MRI scan with diffusion tensor imaging (DTI) acquisition. We verified if there were correlations between the performance on the Brief Cognitive Screening Battery (BCSB) and the Rey Auditory Verbal Learning Test (RAVLT) with DTI parameters. RESULTS: The BCSB delayed recall task correlated with frontotemporoparietal connection bundles, with the hippocampal part of the cingulum bilaterally and with the right superior longitudinal fasciculus. The RAVLT learning and delayed recall scores also correlated with the hippocampal part of the cingulum bilaterally. CONCLUSIONS: Although preliminary, our study suggests that the integrity of white matter frontotemporoparietal fasciculi seems to play a role in episodic memory performance in the low-educated elderly. This finding opens opportunities to study potential targets for memory decline prevention in vulnerable populations. [Mh] Termos MeSH primário: Transtornos da Memória/diagnóstico por imagem Substância Branca/diagnóstico por imagem [Mh] Termos MeSH secundário: Idoso Idoso de 80 Anos ou mais Imagem de Tensor de Difusão Escolaridade Feminino Seres Humanos Imagem por Ressonância Magnética Masculino Transtornos da Memória/etiologia Transtornos da Memória/patologia Testes Neuropsicológicos Substância Branca/patologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180129 [Lr] Data última revisão: 180129 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171214 [St] Status: MEDLINE

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[PMID]: 29240340 [Ti] Título: Update on Current Care guideline: Memory Disorders. [So] Source: Duodecim;133(8):756-7, 2017. [Is] ISSN: 0012-7183 [Cp] País de publicação: Finland [La] Idioma: eng [Ab] Resumo: Any complaint about memory should be examined. Diagnosis is based on international criteria. Basic evaluation consists of medical history, clinical evaluation, cognitive tests and brain imaging. When a diagnosis of Alzheimer's disease (AD), AD with cerebrovascular disease or with Lewy Body disease (LBD), or Dementia associated with Parkinson's disease or LBD is made, evidence-based medical therapy (acetylcholine esterase inhibitor or memantine) is indicated as a part of comprehensive care. In frontotemporal degenerations, these drugs are ineffective. For severe behavioural disorders, other psychoactive medications can be applied if non-pharmacological treatments are not sufficient. [Mh] Termos MeSH primário: Transtornos da Memória/diagnóstico Transtornos da Memória/tratamento farmacológico [Mh] Termos MeSH secundário: Seres Humanos Anamnese Neuroimagem Testes Neuropsicológicos Guias de Prática Clínica como Assunto [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180115 [Lr] Data última revisão: 180115 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171215 [St] Status: MEDLINE

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[PMID]: 29253020 [Au] Autor: Arime Y; Akiyama K [Ad] Endereço: Department of Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan. [Ti] Título: Abnormal neural activation patterns underlying working memory impairment in chronic phencyclidine-treated mice. [So] Source: PLoS One;12(12):e0189287, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Working memory impairment is a hallmark feature of schizophrenia and is thought be caused by dysfunctions in the prefrontal cortex (PFC) and associated brain regions. However, the neural circuit anomalies underlying this impairment are poorly understood. The aim of this study is to assess working memory performance in the chronic phencyclidine (PCP) mouse model of schizophrenia, and to identify the neural substrates of working memory. To address this issue, we conducted the following experiments for mice after withdrawal from chronic administration (14 days) of either saline or PCP (10 mg/kg): (1) a discrete paired-trial variable-delay task in T-maze to assess working memory, and (2) brain-wide c-Fos mapping to identify activated brain regions relevant to this task performance either 90 min or 0 min after the completion of the task, with each time point examined under working memory effort and basal conditions. Correct responses in the test phase of the task were significantly reduced across delays (5, 15, and 30 s) in chronic PCP-treated mice compared with chronic saline-treated controls, suggesting delay-independent impairments in working memory in the PCP group. In layer 2-3 of the prelimbic cortex, the number of working memory effort-elicited c-Fos+ cells was significantly higher in the chronic PCP group than in the chronic saline group. The main effect of working memory effort relative to basal conditions was to induce significantly increased c-Fos+ cells in the other layers of prelimbic cortex and the anterior cingulate and infralimbic cortex regardless of the different chronic regimens. Conversely, this working memory effort had a negative effect (fewer c-Fos+ cells) in the ventral hippocampus. These results shed light on some putative neural networks relevant to working memory impairments in mice chronically treated with PCP, and emphasize the importance of the layer 2-3 of the prelimbic cortex of the PFC. [Mh] Termos MeSH primário: Transtornos da Memória/fisiopatologia Memória de Curto Prazo/fisiologia Neurônios/fisiologia [Mh] Termos MeSH secundário: Animais Encéfalo/metabolismo Masculino Aprendizagem em Labirinto Camundongos Endogâmicos C57BL Fenciclidina Proteínas Proto-Oncogênicas c-fos/metabolismo Cloreto de Sódio Análise e Desempenho de Tarefas Tirosina 3-Mono-Oxigenase/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Proto-Oncogene Proteins c-fos); 451W47IQ8X (Sodium Chloride); EC 1.14.16.2 (Tyrosine 3-Monooxygenase); J1DOI7UV76 (Phencyclidine) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180108 [Lr] Data última revisão: 180108 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171219 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0189287

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1			PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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