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[PMID]: | 29329293 |
[Au] Autor: | Ezeamama AE; Bustinduy AL; Nkwata AK; Martinez L; Pabalan N; Boivin MJ; King CH |
[Ad] Endereço: | Department of Psychiatry, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, United States of America. |
[Ti] Título: | Cognitive deficits and educational loss in children with schistosome infection-A systematic review and meta-analysis. |
[So] Source: | PLoS Negl Trop Dis;12(1):e0005524, 2018 01. | [Is] ISSN: | 1935-2735 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | BACKGROUND: By means of meta-analysis of information from all relevant epidemiologic studies, we examined the hypothesis that Schistosoma infection in school-aged children (SAC) is associated with educational loss and cognitive deficits. METHODOLOGY/PRINCIPAL FINDINGS: This review was prospectively registered in the PROSPERO database (CRD42016040052). Medline, Biosis, and Web of Science were searched for studies published before August 2016 that evaluated associations between Schistosoma infection and cognitive or educational outcomes. Cognitive function was defined in four domains-learning, memory, reaction time, and innate intelligence. Educational outcome measures were defined as attendance and scholastic achievement. Risk of bias (ROB) was evaluated using the Newcastle-Ottawa quality assessment scale. Standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated to compare cognitive and educational measures for Schistosoma infected /not dewormed vs. uninfected/dewormed children. Sensitivity analyses by study design, ROB, and sequential exclusion of individual studies were implemented. Thirty studies from 14 countries, including 38,992 SAC between 5-19 years old, were identified. Compared to uninfected children and children dewormed with praziquantel, the presence of Schistosoma infection and/or non-dewormed status was associated with deficits in school attendance (SMD = -0.36, 95%CI: -0.60, -0.12), scholastic achievement (SMD = -0.58, 95%CI: -0.96, -0.20), learning (SMD = -0.39, 95%CI: -0.70, -0.09) and memory (SMD = -0.28, 95%CI: -0.52, -0.04) tests. By contrast, Schistosoma-infected/non-dewormed and uninfected/dewormed children were similar with respect to performance in tests of reaction time (SMD = -0.06, 95%CI: -0.42, 0.30) and intelligence (SMD = -0.25, 95%CI: -0.57, 0.06). Schistosoma infection-associated deficits in educational measures were robust among observational studies, but not among interventional studies. The significance of infection-associated deficits in scholastic achievement was sensitive to ROB. Schistosoma infection-related deficits in learning and memory tests were invariant by ROB and study design. CONCLUSION/SIGNIFICANCE: Schistosoma infection/non-treatment was significantly associated with educational, learning, and memory deficits in SAC. Early treatment of children in Schistosoma-endemic regions could potentially mitigate these deficits. TRIAL REGISTRATION: ClinicalTrials.gov CRD42016040052. |
[Mh] Termos MeSH primário: |
Disfunção Cognitiva/parasitologia Transtornos de Aprendizagem/parasitologia Transtornos da Memória/parasitologia Esquistossomose/complicações
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[Mh] Termos MeSH secundário: |
Adolescente Animais Anti-Helmínticos/uso terapêutico Criança Pré-Escolar Cognição/fisiologia Seres Humanos Inteligência/fisiologia Memória/fisiologia Testes de Memória e Aprendizagem Praziquantel/uso terapêutico Tempo de Reação/fisiologia Schistosoma/patogenicidade Esquistossomose/tratamento farmacológico Esquistossomose/psicologia
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[Pt] Tipo de publicação: | JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW |
[Nm] Nome de substância:
| 0 (Anthelmintics); 6490C9U457 (Praziquantel) |
[Em] Mês de entrada: | 1801 |
[Cu] Atualização por classe: | 180210 |
[Lr] Data última revisão:
| 180210 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 180113 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1371/journal.pntd.0005524 |
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