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[PMID]:29260547
[Au] Autor:Hong SM; Soe KH; Lee TH; Kim IS; Lee YM; Lim BO
[Ad] Endereço:BK21PLUS Glocal Education Program of Nutraceuticals Development, Konkuk University , Chungju-si, Chungcheongbuk-do 27478, Republic of Korea.
[Ti] Título:Cognitive Improving Effects by Highbush Blueberry (Vaccinium crymbosum L.) Vinegar on Scopolamine-Induced Amnesia Mice Model.
[So] Source:J Agric Food Chem;66(1):99-107, 2018 Jan 10.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The present study aimed to evaluate the preventive effects of highbush blueberry (Vaccinium corymbosum L.) vinegar (BV) on cognitive functions in a scopolamine (Sco)-induced amnesia model in mice. In this study, Sco (1 mg/kg, intraperitoneal injection) was used to induce amnesia. ICR mice were orally administered donepezil (5 mg/kg), blueberry extract (120 mg/kg), and BV (120 mg/kg) for 7 days. After inducing cognitive impairment by Sco, a behavioral assessment using behavior tests (i.e., Y-maze and passive avoidance tests) was performed. The BV group showed significantly restored cognitive function in the behavioral tests. BV facilitated cholinergic activity by inhibiting acetylcholinesterase activity, and enhanced antioxidant enzyme activity. Furthermore, BV was found to be rehabilitated in the cornu ammonis 1 neurons of hippocampus. In our study, we demonstrated that the memory protection conferred by BV was linked to activation of brain-derived neurotrophic factor (BDNF)/cAMP response element binding protein (CREB)/serine-threonine kinase (AKT) signaling.
[Mh] Termos MeSH primário: Amnésia/tratamento farmacológico
Mirtilos Azuis (Planta)/química
Cognição/efeitos dos fármacos
Fármacos Neuroprotetores/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Acetilcolina/metabolismo
Acetilcolinesterase/metabolismo
Amnésia/induzido quimicamente
Animais
Aprendizagem da Esquiva/efeitos dos fármacos
Córtex Cerebral/efeitos dos fármacos
Córtex Cerebral/metabolismo
Modelos Animais de Doenças
Hipocampo/efeitos dos fármacos
Hipocampo/metabolismo
Aprendizagem em Labirinto
Camundongos Endogâmicos ICR
Extratos Vegetais/química
Hidrobrometo de Escopolamina/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neuroprotective Agents); 0 (Plant Extracts); 451IFR0GXB (Scopolamine Hydrobromide); EC 3.1.1.7 (Acetylcholinesterase); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b03965


  2 / 6441 MEDLINE  
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[PMID]:28449397
[Au] Autor:Baghel MS; Thakur MK
[Ad] Endereço:Department of Zoology, Biochemistry and Molecular Biology Laboratory, Centre of Advanced Study, Banaras Hindu University, Varanasi, 221005, India.
[Ti] Título:Differential proteome profiling in the hippocampus of amnesic mice.
[So] Source:Hippocampus;27(8):845-859, 2017 Aug.
[Is] ISSN:1098-1063
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Amnesia or memory loss is associated with brain aging and several neurodegenerative pathologies including Alzheimer's disease (AD). This can be induced by a cholinergic antagonist scopolamine but the underlying molecular mechanism is poorly understood. This study of proteome profiling in the hippocampus could provide conceptual insights into the molecular mechanisms involved in amnesia. To reveal this, mice were administered scopolamine to induce amnesia and memory impairment was validated by novel object recognition test. Using two-dimensional gel electrophoresis coupled with MALDI-MS/MS, we have analyzed the hippocampal proteome and identified 18 proteins which were differentially expressed. Out of these proteins, 11 were downregulated and 7 were upregulated in scopolamine-treated mice as compared to control. In silico analysis showed that the majority of identified proteins are involved in metabolism, catalytic activity, and cytoskeleton architectural functions. STRING interaction network analysis revealed that majority of identified proteins exhibit common association with Actg1 cytoskeleton and Vdac1 energy transporter protein. Furthermore, interaction map analysis showed that Fascin1 and Coronin 1b individually interact with Actg1 and regulate the actin filament dynamics. Vdac1 was significantly downregulated in amnesic mice and showed interaction with other proteins in interaction network. Therefore, we silenced Vdac1 in the hippocampus of normal young mice and found similar impairment in recognition memory of Vdac1 silenced and scopolamine-treated mice. Thus, these findings suggest that Vdac1-mediated disruption of energy metabolism and cytoskeleton architecture might be involved in scopolamine-induced amnesia.
[Mh] Termos MeSH primário: Amnésia/patologia
Regulação da Expressão Gênica/fisiologia
Hipocampo/metabolismo
Proteoma/metabolismo
[Mh] Termos MeSH secundário: Actinas/genética
Actinas/metabolismo
Amnésia/induzido quimicamente
Animais
Antagonistas Colinérgicos/toxicidade
Modelos Animais de Doenças
Expressão Gênica/efeitos dos fármacos
Regulação da Expressão Gênica/efeitos dos fármacos
Hipocampo/efeitos dos fármacos
Masculino
Camundongos
Proteínas dos Microfilamentos/genética
Proteínas dos Microfilamentos/metabolismo
Mapas de Interação de Proteínas
Proteoma/genética
RNA Interferente Pequeno/farmacologia
Receptores Odorantes/genética
Receptores Odorantes/metabolismo
Recognição (Psicologia)/efeitos dos fármacos
Hidrobrometo de Escopolamina/toxicidade
Fatores de Tempo
Canal de Ânion 1 Dependente de Voltagem/química
Canal de Ânion 1 Dependente de Voltagem/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Actins); 0 (Cholinergic Antagonists); 0 (Microfilament Proteins); 0 (Proteome); 0 (RNA, Small Interfering); 0 (Receptors, Odorant); 0 (fascin1 protein, mouse); 145420-64-0 (coronin proteins); 451IFR0GXB (Scopolamine Hydrobromide); EC 1.6.- (Voltage-Dependent Anion Channel 1)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1002/hipo.22735


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[PMID]:28458424
[Au] Autor:Pattanashetti LA; Taranalli AD; Parvatrao V; Malabade RH; Kumar D
[Ad] Endereço:Department of Pharmacology, K.L.E. University's, College of Pharmacy, Belgaum, Karnataka, India.
[Ti] Título:Evaluation of neuroprotective effect of quercetin with donepezil in scopolamine-induced amnesia in rats.
[So] Source:Indian J Pharmacol;49(1):60-64, 2017 Jan-Feb.
[Is] ISSN:1998-3751
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The objective of this study was to evaluate the neuroprotective effect of quercetin with donepezil in scopolamine-induced amnesia in rats. MATERIALS AND METHODS: Five groups of adult male Wistar rats (12 months old) weighing 180-200 g ( = 6) were used. The normal control group received normal saline and test group animals were pretreated orally with quercetin (25 mg/kg), donepezil (3 mg/kg), and a combination of quercetin (25 mg/kg) with donepezil (3 mg/kg), respectively, dosed at every 24 h interval for 14 consecutive days, afterward amnesia was induced by scopolamine (3 mg/kg) on the 14 day through intraperitoneal route. Cognitive performance was assessed by the Morris water maze, elevated plus maze, and passive avoidance paradigm. Acetylcholinesterase enzyme (AchE) level, biochemical markers such as lipid peroxidase (LPO), glutathione (GSH), ß amyloid level, and histopathological study of rat brain were estimated. Statistical analysis was done by one-way analysis of variance, followed by Dunnett's test. ≥ 0.05 was considered statistically significant. RESULTS: Pretreatment with quercetin, donepezil, and their combination showed a significant increase in escape latency, step-through latency, and decreased transfer latency in respective cognitive models of the Morris water maze, passive avoidance test, and elevated plus maze. Further coadministration significantly decreased AchE level, ß amyloid level as compared to individual therapy. Biochemical markers such as elevated GSH, decreased LPO were observed, and histopathological studies revealed the reversal of neuronal damage in the treatment group ( < 0.05) as compared to scopolamine-treated control group. CONCLUSION: Pretreatment with quercetin potentiates the action of donepezil in scopolamine-induced amnesia in rats. The improved cognitive memory could be due to the synergistic effect of the drugs by decreasing AchE level, ß amyloid level, and antioxidant action in rat brain.
[Mh] Termos MeSH primário: Amnésia/prevenção & controle
Indanos/farmacologia
Fármacos Neuroprotetores/farmacologia
Piperidinas/farmacologia
Quercetina/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/administração & dosagem
Antioxidantes/farmacologia
Aprendizagem da Esquiva/efeitos dos fármacos
Cognição/efeitos dos fármacos
Modelos Animais de Doenças
Sinergismo Farmacológico
Indanos/administração & dosagem
Masculino
Aprendizagem em Labirinto/efeitos dos fármacos
Memória/efeitos dos fármacos
Fármacos Neuroprotetores/administração & dosagem
Nootrópicos/administração & dosagem
Nootrópicos/farmacologia
Piperidinas/administração & dosagem
Quercetina/administração & dosagem
Ratos
Ratos Wistar
Hidrobrometo de Escopolamina/toxicidade
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Indans); 0 (Neuroprotective Agents); 0 (Nootropic Agents); 0 (Piperidines); 451IFR0GXB (Scopolamine Hydrobromide); 8SSC91326P (donepezil); 9IKM0I5T1E (Quercetin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.4103/0253-7613.201016


  4 / 6441 MEDLINE  
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[PMID]:29182653
[Au] Autor:Ben Shimon M; Zeimer T; Shavit Stein E; Artan-Furman A; Harnof S; Chapman J; Eisenkraft A; Pick CG; Maggio N
[Ad] Endereço:Department of Neurology, The Chaim Sheba Medical Center, Ramat Gan, Israel.
[Ti] Título:Recovery from trauma induced amnesia correlates with normalization of thrombin activity in the mouse hippocampus.
[So] Source:PLoS One;12(11):e0188524, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Transient amnesia is a common consequence of minimal traumatic brain injury (mTBI). However, while recent findings have addressed the mechanisms involved in its onset, the processes contributing to its recovery have not yet been addressed. Recently, we have found that thrombin is detected at high concentrations in the brain of mice after exposure to mTBI and that in such settings amnesia is rescued by either inhibiting thrombin activity or by blockade of PAR1. Here, we report that mice spontaneously recover from amnesia after two weeks from mTBI exposure. At this time point, long term potentiation was equally evoked in injured vs. control animals with thrombin concentration in the brain being normalized at this stage. These findings, which refer to the specific aspect of memory retrieval upon mTBI, together with our previous work, hint to a strong correlation between cognitive defects in the context of mTBI and thrombin concentrations in the brain. This may suggest that a possible scavenging of thrombin in the brain at early phases following mTBI may improve memory function.
[Mh] Termos MeSH primário: Amnésia/etiologia
Hipocampo/metabolismo
Trombina/fisiologia
Ferimentos e Lesões/complicações
[Mh] Termos MeSH secundário: Animais
Lesões Encefálicas Traumáticas/fisiopatologia
Hipocampo/fisiopatologia
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.4.21.5 (Thrombin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188524


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[PMID]:28745666
[Au] Autor:Alesenko AV; Gavrilova SI; Gutner UA; Lebedeva AO; Shupik MA; Kolykhalov IV; Ponomareva EV; Selezneva ND; Fedorova YB
[Ad] Endereço:Emanuel Institute of Biochemical Physics of RAS, Moscow, Russia.
[Ti] Título:[Detection of effective treatment of amnestic mild cognitive impairement with cereton by testing of lipids markers].
[Ti] Título:Issledovanie éffektivnosti tseretona pri miagkom kognitivnom snizhenii amnesticheskogo tipa na osnove testirovaniia markerov lipidnoi prirody..
[So] Source:Zh Nevrol Psikhiatr Im S S Korsakova;117(6):21-27, 2017.
[Is] ISSN:1997-7298
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:AIM: Determination of effectivity and safety of Cereton (Choline alfoscerate, production by Sotex) 1200 mg/day in the treatment of cognitive functioning disorders in patients with amnestic mild cognitive impairment (aMCI) and determining its influence in the process (after a 3 month course of taking the drug) and 3 months after the end of treatment of aMCI on the change in the content of phosphatidylcholine, sphingomyelin, ceramide-metabolite sphingolipids and the activity of genes controlling the synthesis of enzymes, which control ithe metabolism of sphingomyelin and ceramide (sphingomyelinase and ceramidase). MATERIAL AND METHODS: The study involved a group of elderly patients (20 people), consisting of 14 women and 6 men, aged 51 to 82 years (mean age 70.3±9.1 years). The patients' condition met the criteria for diagnosing aMCI syndrome. Analysis of phosphatidylcholine, sphingomyelin and ceramide in the blood plasma of patients was carried out by thin layer chromatography, expression of sphingomyelinase and ceramidase genes by RtPCR. RESULTS AND CONCLUSION: A sharp increase in the content of phosphatidylcholine and ceramide, the product of sphingomyelin hydrolysis, was detected. Expression of genes (acidic sphingomyelinase and ceramidase), controlling the metabolism of ceramide, is significantly reduced in the majority of patients in the treatment with ceretone. An increase in the level of phosphatidylcholine and a decrease in the expression level of the ceramide metabolism genes during treatment with ceretone and other drugs that affect the metabolism of phosphatidylchodine and sphingolipids can be used as markers of the effectiveness of therapy.
[Mh] Termos MeSH primário: Amnésia/tratamento farmacológico
Ceramidas/metabolismo
Disfunção Cognitiva/tratamento farmacológico
Glicerilfosforilcolina/uso terapêutico
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Biomarcadores/sangue
Biomarcadores/metabolismo
Ceramidases/sangue
Ceramidases/genética
Ceramidases/metabolismo
Ceramidas/sangue
Feminino
Expressão Gênica
Glicerilfosforilcolina/efeitos adversos
Seres Humanos
Masculino
Meia-Idade
Fosfatidilcolinas/sangue
Fosfatidilcolinas/metabolismo
Esfingomielina Fosfodiesterase/sangue
Esfingomielina Fosfodiesterase/genética
Esfingomielina Fosfodiesterase/metabolismo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Ceramides); 0 (Phosphatidylcholines); 60M22SGW66 (Glycerylphosphorylcholine); EC 3.1.4.12 (Sphingomyelin Phosphodiesterase); EC 3.5.1.23 (Ceramidases)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.17116/jnevro20171176121-27


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[PMID]:29050391
[Au] Autor:Harrison NA; Johnston K; Corno F; Casey SJ; Friedner K; Humphreys K; Jaldow EJ; Pitkanen M; Kopelman MD
[Ad] Endereço:King's College London, Academic Neuropsychiatry, Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, London, SE1 7EH UK.
[Ti] Título:Psychogenic amnesia: syndromes, outcome, and patterns of retrograde amnesia.
[So] Source:Brain;140(9):2498-2510, 2017 Sep 01.
[Is] ISSN:1460-2156
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:There are very few case series of patients with acute psychogenic memory loss (also known as dissociative/functional amnesia), and still fewer studies of outcome, or comparisons with neurological memory-disordered patients. Consequently, the literature on psychogenic amnesia is somewhat fragmented and offers little prognostic value for individual patients. In the present study, we reviewed the case records and neuropsychological findings in 53 psychogenic amnesia cases (ratio of 3:1, males:females), in comparison with 21 consecutively recruited neurological memory-disordered patients and 14 healthy control subjects. In particular, we examined the pattern of retrograde amnesia on an assessment of autobiographical memory (the Autobiographical Memory Interview). We found that our patients with psychogenic memory loss fell into four distinct groups, which we categorized as: (i) fugue state; (ii) fugue-to-focal retrograde amnesia; (iii) psychogenic focal retrograde amnesia following a minor neurological episode; and (iv) patients with gaps in their memories. While neurological cases were characterized by relevant neurological symptoms, a history of a past head injury was actually more common in our psychogenic cases (P = 0.012), perhaps reflecting a 'learning episode' predisposing to later psychological amnesia. As anticipated, loss of the sense of personal identity was confined to the psychogenic group. However, clinical depression, family/relationship problems, financial/employment problems, and failure to recognize the family were also statistically more common in that group. The pattern of autobiographical memory loss differed between the psychogenic groups: fugue cases showed a severe and uniform loss of memories for both facts and events across all time periods, whereas the two focal retrograde amnesia groups showed a 'reversed' temporal gradient with relative sparing of recent memories. After 3-6 months, the fugue patients had improved to normal scores for facts and near-normal scores for events. By contrast, the two focal retrograde amnesia groups showed less improvement and continued to show a reversed temporal gradient. In conclusion, the outcome in psychogenic amnesia, particularly those characterized by fugue, is better than generally supposed. Findings are interpreted in terms of Markowitsch's and Kopelman's models of psychogenic amnesia, and with respect to Anderson's neuroimaging findings in memory inhibition.
[Mh] Termos MeSH primário: Amnésia Retrógrada/classificação
Amnésia/classificação
[Mh] Termos MeSH secundário: Adulto
Idoso
Amnésia/complicações
Amnésia Retrógrada/complicações
Traumatismos Craniocerebrais/complicações
Traumatismos Craniocerebrais/epidemiologia
Depressão/complicações
Depressão/epidemiologia
Conflito Familiar
Feminino
Seres Humanos
Londres/epidemiologia
Masculino
Memória Episódica
Meia-Idade
Testes Neuropsicológicos
Autoimagem
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171021
[St] Status:MEDLINE
[do] DOI:10.1093/brain/awx186


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[PMID]:28987052
[Au] Autor:Ulatowska J; Sawicka M
[Ad] Endereço:Instytut Psychologii Stosowanej, Akademia Pedagogiki Specjalnej.
[Ti] Título:Recovered memories in clinical practice - a research review.
[Ti] Título:Odzyskiwanie wspomnien w praktyce klinicznej ­ przeglad badan..
[So] Source:Psychiatr Pol;51(4):609-618, 2017 Aug 29.
[Is] ISSN:2391-5854
[Cp] País de publicação:Poland
[La] Idioma:eng; pol
[Ab] Resumo:The problem of recovered memories concerns not only psychiatry, psychology or psychotherapy but it is also an important legal and judicial issue. Clinicians, scientists and lawyers are in unsolved dispute, called "memory wars", concerning the credibility of these memories, especially if they were recovered following specific therapeutic techniques or using self-help books. Many cases of recovered memories of childhood sexual abuse brought legal action against alleged offender. Investigations showed, however, that some of these memories were false. The aim of this article is to try to answer key questions concerning the issue if recovered memories: Is it possible not to remember traumatic experiences? In what conditions the autobiographical memories can be implanted? Is it possible to make a list of therapeutic techniques evoking false memories? What are the characteristics of a patient particularly vulnerable for false memories creation? Answers to the above questions are a ground for considerations concerning creation of favorable conditions for therapeutic work and minimizing mistakes resulting from the risk of implanting false memories.
[Mh] Termos MeSH primário: Imagens (Psicoterapia)
Transtornos Mentais/terapia
Rememoração Mental/fisiologia
Transtornos de Estresse Pós-Traumáticos/psicologia
[Mh] Termos MeSH secundário: Amnésia/psicologia
Seres Humanos
Entrevista Psicológica
Transtornos Mentais/psicologia
Repressão Psicológica
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171008
[St] Status:MEDLINE


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[PMID]:28763447
[Au] Autor:Mijalkov M; Kakaei E; Pereira JB; Westman E; Volpe G; Alzheimer's Disease Neuroimaging Initiative
[Ad] Endereço:UNAM-National Nanotechnology Research Center & Department of Physics, Bilkent University, Ankara, Turkey.
[Ti] Título:BRAPH: A graph theory software for the analysis of brain connectivity.
[So] Source:PLoS One;12(8):e0178798, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The brain is a large-scale complex network whose workings rely on the interaction between its various regions. In the past few years, the organization of the human brain network has been studied extensively using concepts from graph theory, where the brain is represented as a set of nodes connected by edges. This representation of the brain as a connectome can be used to assess important measures that reflect its topological architecture. We have developed a freeware MatLab-based software (BRAPH-BRain Analysis using graPH theory) for connectivity analysis of brain networks derived from structural magnetic resonance imaging (MRI), functional MRI (fMRI), positron emission tomography (PET) and electroencephalogram (EEG) data. BRAPH allows building connectivity matrices, calculating global and local network measures, performing non-parametric permutations for group comparisons, assessing the modules in the network, and comparing the results to random networks. By contrast to other toolboxes, it allows performing longitudinal comparisons of the same patients across different points in time. Furthermore, even though a user-friendly interface is provided, the architecture of the program is modular (object-oriented) so that it can be easily expanded and customized. To demonstrate the abilities of BRAPH, we performed structural and functional graph theory analyses in two separate studies. In the first study, using MRI data, we assessed the differences in global and nodal network topology in healthy controls, patients with amnestic mild cognitive impairment, and patients with Alzheimer's disease. In the second study, using resting-state fMRI data, we compared healthy controls and Parkinson's patients with mild cognitive impairment.
[Mh] Termos MeSH primário: Doença de Alzheimer/diagnóstico por imagem
Encéfalo/fisiologia
Disfunção Cognitiva/diagnóstico por imagem
Processamento de Imagem Assistida por Computador/métodos
Doença de Parkinson/diagnóstico por imagem
Software
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Algoritmos
Amnésia/diagnóstico por imagem
Estudos de Casos e Controles
Análise por Conglomerados
Estudos de Coortes
Conectoma/métodos
Eletroencefalografia
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Rede Nervosa/fisiopatologia
Vias Neurais/fisiopatologia
Tomografia por Emissão de Pósitrons
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170802
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178798


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[PMID]:28716085
[Au] Autor:Eun CS; Lim JS; Lee J; Lee SP; Yang SA
[Ad] Endereço:Major in Food Science and Technology, Keimyung University, Daegu, 42601, Republic of Korea.
[Ti] Título:The protective effect of fermented Curcuma longa L. on memory dysfunction in oxidative stress-induced C6 gliomal cells, proinflammatory-activated BV2 microglial cells, and scopolamine-induced amnesia model in mice.
[So] Source:BMC Complement Altern Med;17(1):367, 2017 Jul 17.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Curcuma longa L. is a well-known medicinal plant that has been used for its anti-cancer, neuroprotective, and hepatoprotective effects. However, the neuroprotective effect of fermented C. longa (FCL) has not been reported. Therefore, in this study, the effectiveness of FCL for the regulation of memory dysfunction was investigated in two brain cell lines (rat glioma C6 and murine microglia BV2) and scopolamine-treated mice. METHODS: C. longa powder was fermented by 5% Lactobacillus plantarum K154 containing 2% (w/v) yeast extract at 30 °C for 72 h followed by sterilization at 121 °C for 15 min. The protective effects of fermented C. longa (FCL) on oxidative stress induced cell death were analyzed by MTT assay in C6 cells. The anti-inflammatory effects of FCL were investigated by measuring the production of nitric oxide (NO) and prostaglandin E (PGE ) as well as the expression levels of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) in LPS-stimulated BV2 cells. The step-through passive avoidance test, Morris water maze test, acetylcholinesterase (AChE) activity, and expression of cAMP response element-binding protein (CREB) and brain-derived neurotropic factor (BDNF) were employed to determine the effects of FCL on scopolamine-induced memory deficit in mice. The contents of curcuminoids were analyzed through LC/MS. RESULTS: Pretreatment with FCL effectively prevented the cell death induced by oxidative stress in C6 cells. Moreover, FCL inhibited the production NO and PGE via the inhibition of iNOS and COX-2 expression in BV2 cells. FCL significantly attenuated scopolamine-induced memory impairment in mice and prevented scopolamine-induced AChE activity in the hippocampus. Additionally, FCL reversed the reduction of CREB and BDNF expression. The curcuminoids content in FCL was 1.44%. CONCLUSION: FCL pretreatment could alleviate scopolamine-induced memory impairment in mice, as well as oxidative stress and inflammation in C6 and BV2 cells, respectively. Thus, FCL might be a useful material for preventing impairment of learning and memory.
[Mh] Termos MeSH primário: Amnésia/tratamento farmacológico
Encéfalo/efeitos dos fármacos
Curcuma/química
Inflamação/tratamento farmacológico
Fármacos Neuroprotetores/uso terapêutico
Estresse Oxidativo/efeitos dos fármacos
Fitoterapia
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Amnésia/induzido quimicamente
Amnésia/metabolismo
Animais
Anti-Inflamatórios/farmacologia
Anti-Inflamatórios/uso terapêutico
Antioxidantes/farmacologia
Antioxidantes/uso terapêutico
Encéfalo/metabolismo
Fator Neurotrófico Derivado do Encéfalo/metabolismo
Linhagem Celular
Curcumina/análise
Curcumina/farmacologia
Curcumina/uso terapêutico
Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/metabolismo
Fermentação
Inflamação/induzido quimicamente
Inflamação/metabolismo
Mediadores da Inflamação/metabolismo
Lipopolissacarídeos
Masculino
Transtornos da Memória
Camundongos Endogâmicos ICR
Fármacos Neuroprotetores/farmacologia
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
Ratos
Hidrobrometo de Escopolamina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Brain-Derived Neurotrophic Factor); 0 (Creb1 protein, mouse); 0 (Cyclic AMP Response Element-Binding Protein); 0 (Inflammation Mediators); 0 (Lipopolysaccharides); 0 (Neuroprotective Agents); 0 (Plant Extracts); 451IFR0GXB (Scopolamine Hydrobromide); EC 3.1.1.7 (Acetylcholinesterase); IT942ZTH98 (Curcumin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1880-3


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[PMID]:28704207
[Au] Autor:Casali MB; Palazzo E; Blandino A; Battistini A; Motta F; Kustermann A; Cattaneo C
[Ad] Endereço:From the *Institute of Legal Medicine, Università degli Studi di Milano, Milan; and †SVSeD, Clinica Luigi Mangiagalli, Ospedale Policlinico di Milano, Milan, Italy.
[Ti] Título:The Adult Male Rape Victim: Forensic Description of a Series of 57 Cases.
[So] Source:Am J Forensic Med Pathol;38(3):175-179, 2017 Sep.
[Is] ISSN:1533-404X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A retrospective analysis on 57 adult male victims of sexual violence has been performed. Age, nationality and anamnesis of the victims, location of the assault, type of violence, number and identity of the assailants, presence of physical injuries, lapse of time between the assault and the request of medical assistance, and toxicological and semen detection tests were analyzed. Victims were mostly in the 31- to 40-year age group. Ten victims referred themselves as either active homosexuals or bisexuals. Forced oral and/or anal penetration was registered in 86.8% of cases, mostly performed by a single assailant. Anogenital injuries were recorded in 61.4% of cases, whereas extragenital injuries in 35.1%: abrasions and perianal reddening were the most frequent acute anogenital marks, whereas the head and lower limbs were the body parts most commonly affected by blunt trauma. No clinically severe injuries were found. Anal and perianal swabs for semen detection tested positive in less than 20% cases, whereas oral swabs always tested negative. When performed, nearly 50% of cases tested positive in drug tests, above all for psychoactive substances. No definite forensic diagnosis in terms of confirmation of rape was possible on the basis of type and topography of injuries.
[Mh] Termos MeSH primário: Vítimas de Crime/estatística & dados numéricos
Estupro/estatística & dados numéricos
Delitos Sexuais/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Amnésia/epidemiologia
Canal Anal/lesões
Bissexualidade/estatística & dados numéricos
Homossexualidade Masculina/estatística & dados numéricos
Seres Humanos
Itália/epidemiologia
Masculino
Estudos Retrospectivos
Detecção do Abuso de Substâncias/estatística & dados numéricos
Ferimentos e Lesões/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1097/PAF.0000000000000333



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