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Pesquisa : C10.597.606.762.100 [Categoria DeCS]
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  1 / 1892 MEDLINE  
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[PMID]:28421896
[Au] Autor:Yoon B; Shim YS; Hong YJ; Choi SH; Park HK; Park SA; Jeong JH; Yoon SJ; Yang DW
[Ad] Endereço:1 Department of Neurology, Konyang University Hospital, College of Medicine, Konyang University, Daejeon, Republic of Korea.
[Ti] Título:Anosognosia and Its Relation to Psychiatric Symptoms in Early-Onset Alzheimer Disease.
[So] Source:J Geriatr Psychiatry Neurol;30(3):170-177, 2017 May.
[Is] ISSN:0891-9887
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We investigated differences in the prevalence of anosognosia and neuropsychiatric symptoms (NPSs) characteristics according to disease severity in patients with early-onset Alzheimer disease (EOAD). METHODS: We recruited 616 patients with EOAD. We subdivided participants into 2 groups based on the presence or absence of anosognosia and then again by Clinical Dementia Rating (CDR) scale. We compared the differences in the Neuropsychiatric Inventory (NPI) scores according to anosognosia and disease severity. RESULTS: The percentage of patients with anosognosia in each CDR group steadily increased as the CDR rating increased (CDR 0.5 8.6% vs CDR 1 13.6% vs CDR 2 26.2%). The NPI total score was significantly higher in patients with anosognosia in the CDR 0.5 and 1 groups; by contrast, it had no association in the CDR 2 group. Frontal lobe functions were associated with anosognosia only in the CDR 0.5 and 1 groups. After stratification by CDR, in the CDR 0.5 group, the prevalence of agitation ( P = .040) and appetite ( P = .013) was significantly higher in patients with anosognosia. In the CDR 1 group, patients with anosognosia had a significantly higher prevalence of delusions ( P = .032), hallucinations ( P = .048), and sleep disturbances ( P = .047). In the CDR 2 group, we found no statistical difference in the frequency of symptoms between patients with and without anosognosia. CONCLUSION: These results confirm that the prevalence of anosognosia as well as the individual NPS and cognitive functions associated with it differ according to EOAD severity.
[Mh] Termos MeSH primário: Agnosia/psicologia
Doença de Alzheimer/psicologia
[Mh] Termos MeSH secundário: Afeto
Agnosia/diagnóstico
Agnosia/epidemiologia
Agnosia/fisiopatologia
Doença de Alzheimer/diagnóstico
Doença de Alzheimer/epidemiologia
Doença de Alzheimer/fisiopatologia
Apetite
Cognição
Delusões/epidemiologia
Feminino
Lobo Frontal/fisiopatologia
Alucinações/epidemiologia
Seres Humanos
Masculino
Meia-Idade
Testes Neuropsicológicos
Prevalência
Transtornos do Sono-Vigília/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170427
[Lr] Data última revisão:
170427
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.1177/0891988717700508


  2 / 1892 MEDLINE  
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[PMID]:28357826
[Au] Autor:Azzopardi CP; Matity L; Muscat S
[Ad] Endereço:Hyperbaric Unit, Mater Dei Hospital, Msida, Malta MSD 2090, charles.a.azzopardi@gov.mt.
[Ti] Título:Anton's syndrome as a presentation of decompression illness.
[So] Source:Diving Hyperb Med;47(1):59-60, 2017 Mar.
[Is] ISSN:1833-3516
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:We present a case of a patient with Anton's syndrome due to decompression illness (DCI) after recreational scuba diving. Visual anosognosia, or denial of loss of vision, which is associated with lack of awareness regarding visual loss in the setting of cortical blindness, is known as Anton's syndrome (also termed Anton-Babinski syndrome). Our patient presented with progressive neurological DCI treated with repeated recompression. The anosogosia resolved after 48 h. Subsequent echocardiography revealed a persistent (patent) foramen ovale.
[Mh] Termos MeSH primário: Agnosia/etiologia
Cegueira Cortical/etiologia
Doença da Descompressão/complicações
[Mh] Termos MeSH secundário: Agnosia/diagnóstico
Cegueira Cortical/diagnóstico
Encéfalo/diagnóstico por imagem
Doença da Descompressão/diagnóstico por imagem
Forame Oval Patente/diagnóstico por imagem
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170502
[Lr] Data última revisão:
170502
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170331
[St] Status:MEDLINE


  3 / 1892 MEDLINE  
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[PMID]:28284488
[Au] Autor:Strappini F; Pelli DG; Di Pace E; Martelli M
[Ad] Endereço:Department of Psychology, University of Rome La Sapienza, Rome, Italy; Neuropsychology Research Centre, IRCCS Foundation Hospital Santa Lucia, Rome, Italy; Neurobiology Department, Weizmann Institute of Science, Rehovot, Israel.
[Ti] Título:Agnosic vision is like peripheral vision, which is limited by crowding.
[So] Source:Cortex;89:135-155, 2017 Apr.
[Is] ISSN:1973-8102
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Visual agnosia is a neuropsychological impairment of visual object recognition despite near-normal acuity and visual fields. A century of research has provided only a rudimentary account of the functional damage underlying this deficit. We find that the object-recognition ability of agnosic patients viewing an object directly is like that of normally-sighted observers viewing it indirectly, with peripheral vision. Thus, agnosic vision is like peripheral vision. We obtained 14 visual-object-recognition tests that are commonly used for diagnosis of visual agnosia. Our "standard" normal observer took these tests at various eccentricities in his periphery. Analyzing the published data of 32 apperceptive agnosia patients and a group of 14 posterior cortical atrophy (PCA) patients on these tests, we find that each patient's pattern of object recognition deficits is well characterized by one number, the equivalent eccentricity at which our standard observer's peripheral vision is like the central vision of the agnosic patient. In other words, each agnosic patient's equivalent eccentricity is conserved across tests. Across patients, equivalent eccentricity ranges from 4 to 40 deg, which rates severity of the visual deficit. In normal peripheral vision, the required size to perceive a simple image (e.g., an isolated letter) is limited by acuity, and that for a complex image (e.g., a face or a word) is limited by crowding. In crowding, adjacent simple objects appear unrecognizably jumbled unless their spacing exceeds the crowding distance, which grows linearly with eccentricity. Besides conservation of equivalent eccentricity across object-recognition tests, we also find conservation, from eccentricity to agnosia, of the relative susceptibility of recognition of ten visual tests. These findings show that agnosic vision is like eccentric vision. Whence crowding? Peripheral vision, strabismic amblyopia, and possibly apperceptive agnosia are all limited by crowding, making it urgent to know what drives crowding. Acuity does not (Song et al., 2014), but neural density might: neurons per deg in the crowding-relevant cortical area.
[Mh] Termos MeSH primário: Agnosia/diagnóstico
Recognição (Psicologia)/fisiologia
Visão Ocular/fisiologia
Percepção Visual/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Agnosia/fisiopatologia
Criança
Feminino
Seres Humanos
Masculino
Meia-Idade
Reconhecimento Visual de Modelos/fisiologia
Testes Visuais
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE


  4 / 1892 MEDLINE  
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[PMID]:28283961
[Au] Autor:Sunderaraman P; Cosentino S
[Ad] Endereço:Cognitive Neuroscience Division of the Taub Institute for Research on Alzheimer's Disease, Columbia University Medical Center, New York, NY, USA.
[Ti] Título:Integrating the Constructs of Anosognosia and Metacognition: a Review of Recent Findings in Dementia.
[So] Source:Curr Neurol Neurosci Rep;17(3):27, 2017 Mar.
[Is] ISSN:1534-6293
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The current review integrates recent findings regarding the construct of self-awareness in dementia from both clinical and cognitive perspectives. We present the predominant theoretical models of awareness and summarize both traditional and emerging approaches to assessing awareness from clinical and meta-cognitive perspectives. In this review, we focus primarily on findings from recent studies in anosognosia and meta-cognition in the context of neurodegenerative disease with special emphasis on Alzheimer's disease and frontotemporal dementia. Emerging trends in the study of awareness, including examination of the longitudinal course of anosognosia, and investigation of the neural substrates underlying meta-cognitive abilities are addressed. Finally, the practical importance of studying and assessing awareness from both theoretical and clinical angles is emphasized.
[Mh] Termos MeSH primário: Agnosia/psicologia
Doença de Alzheimer/psicologia
Conscientização
Demência Frontotemporal/psicologia
Metacognição
[Mh] Termos MeSH secundário: Idoso
Seres Humanos
Modelos Psicológicos
Testes Neuropsicológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170312
[St] Status:MEDLINE
[do] DOI:10.1007/s11910-017-0734-1


  5 / 1892 MEDLINE  
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[PMID]:28122771
[Au] Autor:Renfroe JB; Turner TH; Hinson VK
[Ad] Endereço:Department of Neurology, Medical University of South Carolina, Charleston, SC, USA jennarenfroephd@gmail.com.
[Ti] Título:Assessing Visuospatial Skills in Parkinson's: Comparison of Neuropsychological Assessment Battery Visual Discrimination to the Judgment of Line Orientation.
[So] Source:Arch Clin Neuropsychol;32(1):123-127, 2017 Feb.
[Is] ISSN:1873-5843
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Judgment of Line Orientation (JOLO) test is widely used in assessing visuospatial deficits in Parkinson's disease (PD). The neuropsychological assessment battery (NAB) offers the Visual Discrimination test, with age and education correction, parallel forms, and co-normed standardization sample for comparisons within and between domains. However, NAB Visual Discrimination has not been validated in PD, and may not measure the same construct as JOLO. METHOD: A heterogeneous sample of 47 PD patients completed the JOLO and NAB Visual Discrimination within a broader neuropsychological evaluation. Pearson correlations assessed relationships between JOLO and NAB Visual Discrimination performances. RESULTS: Raw and demographically corrected scores from JOLO and Visual Discrimination were only weakly correlated. NAB Visual Discrimination subtest was moderately correlated with overall cognitive functioning, whereas the JOLO was not. CONCLUSIONS: Despite apparent virtues, results do not support NAB Visual Discrimination as an alternative to JOLO in assessing visuospatial functioning in PD.
[Mh] Termos MeSH primário: Agnosia/diagnóstico
Discriminação (Psicologia)
Testes Neuropsicológicos
Orientação Espacial
Doença de Parkinson/diagnóstico
Doença de Parkinson/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Agnosia/complicações
Cognição
Feminino
Seres Humanos
Masculino
Meia-Idade
Doença de Parkinson/complicações
Percepção Visual
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170213
[Lr] Data última revisão:
170213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170127
[St] Status:MEDLINE
[do] DOI:10.1093/arclin/acw102


  6 / 1892 MEDLINE  
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[PMID]:27903133
[Au] Autor:Carr AR; Samimi MS; Paholpak P; Jimenez EE; Mendez MF
[Ad] Endereço:a V.A. Greater Los Angeles Healthcare System , Los Angeles , CA , USA.
[Ti] Título:Emotional quotient in frontotemporal dementia vs. Alzheimer's disease: the role of socioemotional agnosia.
[So] Source:Cogn Neuropsychiatry;22(1):28-38, 2017 Jan.
[Is] ISSN:1464-0619
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Socioemotional dysfunction distinguishes behavioural variant frontotemporal dementia (bvFTD) from other dementias. Patients with bvFTD not only have early social impairment and emotional blunting, but they also have agnosia of their socioemotional dysfunction. METHODS: To investigate the relationship between agnosia and dysfunction, we assessed self-knowledge of socioemotional dysfunction with an emotional quotient (EQ) scale administered to 12 patients with bvFTD and a comparison group of 12 age-matched patients with Alzheimer's disease (AD), and compared these self-ratings to caregiver ratings of social dysfunction and emotional blunting. RESULTS: The bvFTD patients self-rated as having higher EQs than the AD patients, particularly higher self-ratings of their Social Skills, an EQ subscale which correlated with increased emotional blunting. On within-groups analysis, the bvFTD patients' high self-ratings of their EQ Appraisal of Emotions correlated with increased socioemotional dysfunction, whereas all of the AD patients' self-ratings correlated appropriately with their degree of dysfunction. CONCLUSIONS: Large socioemotional agnosia scores (EQ minus function) distinguishes bvFTD from AD. Additionally, in bvFTD, agnosia specifically for their ability to appreciate others' emotions correlates with the degree of socioemotional dysfunction, suggesting a role for socioemotional agnosia in increasing socioemotional dysfunction.
[Mh] Termos MeSH primário: Agnosia
Doença de Alzheimer/psicologia
Demência Frontotemporal/psicologia
Transtornos do Humor/psicologia
Escalas de Graduação Psiquiátrica
[Mh] Termos MeSH secundário: Idoso
Doença de Alzheimer/complicações
California
Feminino
Demência Frontotemporal/complicações
Seres Humanos
Masculino
Transtornos do Humor/complicações
Sensibilidade e Especificidade
Inquéritos e Questionários
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161202
[St] Status:MEDLINE
[do] DOI:10.1080/13546805.2016.1259612


  7 / 1892 MEDLINE  
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[PMID]:27484245
[Au] Autor:Bartolomeo P; de Vito S; Seidel Malkinson T
[Ad] Endereço:Inserm U 1127, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, Paris, France; CNRS, UMR 7225, Paris, France; Institut du Cerveau et de la Moelle épinière, ICM, Paris, France. Electronic address: paolo.bartolomeo@gmail.com.
[Ti] Título:Space-related confabulations after right hemisphere damage.
[So] Source:Cortex;87:166-173, 2017 Feb.
[Is] ISSN:1973-8102
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Confabulations usually refer to memory distortions, characterized by the production of verbal statements or actions that are inconsistent with the patient's history and present situation. However, behavioral patterns reminiscent of memory confabulations can also occur in patients with right hemisphere damage, in relation to their personal, peripersonal or extrapersonal space. Thus, such patients may be unaware of their left hemiplegia and confabulate about it (anosognosia), deny the ownership of their left limbs (somatoparaphrenia), insult and hit them (misoplegia), or experience a "third", supernumerary left limb. Right brain-damaged patients can also sometimes confabulate about the left, neglected part of images presented in their peripersonal space, or believe to be in another place (reduplicative paramnesia). We review here these instances of confabulation occurring after right hemisphere damage, and propose that they might reflect, at least partially, the attempts of the left hemisphere to make sense of inappropriate input received from the damaged right hemisphere.
[Mh] Termos MeSH primário: Agnosia/psicologia
Hemiplegia/psicologia
Transtornos da Memória/psicologia
Transtornos da Percepção/psicologia
Percepção Espacial/fisiologia
[Mh] Termos MeSH secundário: Agnosia/etiologia
Atenção/fisiologia
Hemiplegia/etiologia
Seres Humanos
Transtornos da Memória/etiologia
Testes Neuropsicológicos
Transtornos da Percepção/etiologia
Acidente Vascular Cerebral/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160804
[St] Status:MEDLINE


  8 / 1892 MEDLINE  
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[PMID]:27093371
[Au] Autor:Morin A
[Ad] Endereço:a Department of Psychology , Mount Royal University , Calgary , AB , Canada.
[Ti] Título:The "self-awareness-anosognosia" paradox explained: How can one process be associated with activation of, and damage to, opposite sides of the brain?
[So] Source:Laterality;22(1):105-119, 2017 Jan.
[Is] ISSN:1464-0678
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Healthy volunteers engaged in self-referential tasks such as reflecting on their personality traits exhibit mostly left lateralized brain activation, yet patients with lack of awareness of their deficit suffer from predominantly right hemisphere damage. How can the same basic process of self-awareness be associated with opposite sides of the brain? Anosognosia and self-awareness substantially differ on important dimensions and thus should not be equated. It is proposed that (1) anosognosia does not actually result from uniquely right hemisphere damage; (2) self-awareness and anosognosia do not constitute unitary concepts and encompass multiple other related processes, most likely associated with activity in distinct anatomical networks; and (3) impaired awareness of deficit is mostly caused by problems with self-monitoring, pre-/post-brain damage comparisons of performance, and episodic memory, and is more passive, unintentional, and about the body. Self-awareness produced by inviting participants to intentionally and actively think about more mental aspects of the self relies on judgements, inferential reasoning, imagination, and semantic memory. Consequently, the "self-awareness-anosognosia" paradox is only apparent. Furthermore, the claim that healthy self-awareness is located in the right hemisphere because anosognosia results from damage to this side of the brain must be fallacious.
[Mh] Termos MeSH primário: Agnosia/fisiopatologia
Conscientização/fisiologia
Encéfalo/fisiopatologia
Lateralidade Funcional/fisiologia
Autoimagem
[Mh] Termos MeSH secundário: Agnosia/patologia
Encéfalo/patologia
Seres Humanos
Modelos Neurológicos
Modelos Psicológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170203
[Lr] Data última revisão:
170203
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160420
[St] Status:MEDLINE
[do] DOI:10.1080/1357650X.2016.1173049


  9 / 1892 MEDLINE  
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[PMID]:26822668
[Au] Autor:Aglieri V; Watson R; Pernet C; Latinus M; Garrido L; Belin P
[Ad] Endereço:Institut des Neurosciences de la Timone, UMR 7289, CNRS and Université Aix-Marseille, Marseille, France. virginia.aglieri@univ-amu.fr.
[Ti] Título:The Glasgow Voice Memory Test: Assessing the ability to memorize and recognize unfamiliar voices.
[So] Source:Behav Res Methods;49(1):97-110, 2017 Feb.
[Is] ISSN:1554-3528
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:One thousand one hundred and twenty subjects as well as a developmental phonagnosic subject (KH) along with age-matched controls performed the Glasgow Voice Memory Test, which assesses the ability to encode and immediately recognize, through an old/new judgment, both unfamiliar voices (delivered as vowels, making language requirements minimal) and bell sounds. The inclusion of non-vocal stimuli allows the detection of significant dissociations between the two categories (vocal vs. non-vocal stimuli). The distributions of accuracy and sensitivity scores (d') reflected a wide range of individual differences in voice recognition performance in the population. As expected, KH showed a dissociation between the recognition of voices and bell sounds, her performance being significantly poorer than matched controls for voices but not for bells. By providing normative data of a large sample and by testing a developmental phonagnosic subject, we demonstrated that the Glasgow Voice Memory Test, available online and accessible from all over the world, can be a valid screening tool (~5 min) for a preliminary detection of potential cases of phonagnosia and of "super recognizers" for voices.
[Mh] Termos MeSH primário: Memória
Testes Psicológicos
Recognição (Psicologia)
Voz
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Agnosia/diagnóstico
Estudos de Casos e Controles
Feminino
Seres Humanos
Masculino
Meia-Idade
Som
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160130
[St] Status:MEDLINE
[do] DOI:10.3758/s13428-015-0689-6


  10 / 1892 MEDLINE  
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[PMID]:26226378
[Au] Autor:Allen R; Cocchini G
[Ad] Endereço:a Department of Psychology, Goldsmiths , University of London , London , England.
[Ti] Título:Treatment response profiles: An extension of the double dissociation concept in neuropsychological research.
[So] Source:Neuropsychol Rehabil;27(1):80-98, 2017 Jan.
[Is] ISSN:1464-0694
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The presence of double dissociations in patients with neurological damage has long been used as evidence that the dissociated functions cannot be explained in terms of a common system or module. Shallice (1988) has suggested that a second procedure, the double critical variable method, can provide evidence for a similar conclusion. In this paper we examine the situation where double dissocations are not naturally present, suggesting that the two phenomena are merely aspects of the same underlying condition. We propose that the logic of the double critical variable method can be applied in this situation, whenever responses to treatment vary in a particular manner across syndromes and patients. This logic was previously used by Beschin, Cocchini, Allen, and Della Sala (2012) to show a dissociation between anosognosia and neglect in stroke patients; we suggest that it might have a more general application. As an aid in understanding the concept we also introduce the performance/performance curve; this builds on the existing idea of performance/resource curves to draw a single graph from two such curves, whose points may be derived from direct observation. It enables the empirical testing of hypotheses about the functional form of unobservable performance/resource relationships, and may be of use beyond the existing application to treatment response profiles.
[Mh] Termos MeSH primário: Reabilitação do Acidente Vascular Cerebral
Acidente Vascular Cerebral/fisiopatologia
Análise e Desempenho de Tarefas
[Mh] Termos MeSH secundário: Agnosia/fisiopatologia
Agnosia/reabilitação
Seres Humanos
Transtornos da Percepção/fisiopatologia
Transtornos da Percepção/reabilitação
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170206
[Lr] Data última revisão:
170206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150731
[St] Status:MEDLINE



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