Base de dados : MEDLINE
Pesquisa : C10.597.704 [Categoria DeCS]
Referências encontradas : 4437 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 444 ir para página                         

  1 / 4437 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29390531
[Au] Autor:Tu Y; Gao F
[Ad] Endereço:Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
[Ti] Título:Dexmedetomidine-based monitored conscious sedation combined local anesthesia for levator resection in a 10-year-old child with Marcus Gunn jaw-winking synkinesis: A case report.
[So] Source:Medicine (Baltimore);96(51):e9369, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Levator resection has become a routine procedure for patients with severe Marcus Gunn jaw-winking synkinesis (MGJWS). To optimize the surgical outcome, adult patients need to be kept awake, or easily aroused and responsive to verbal commands during the operation. However, levator resection is commonly performed under general anesthesia in pediatric patients. In the present case, we described a successful anesthetic protocol of conscious sedation with local anesthesia for levator resection in a child. PATIENT CONCERNS: A 10-year-old boy with MGJWS was admitted to our hospital and scheduled for levator resection. The patient was born through a normal delivery and had no previous history of allergy, no comorbidity, and no history of receiving anesthesia or operation. The laboratory tests of the patient were unremarkable. DIAGNOSES: The diagnosis of MGJWS was made by two experienced ophthalmologists. INTERVENTIONS: A 10-year-old boy with MGJWS was admitted to our hospital and scheduled for levator resection. The levator resection was performed under monitored conscious sedation with dexmedetomidine and local anesthesia. OUTCOMES: Patient with spontaneous breathing responded normally to verbal commands throughout the operation, and no adverse events occurred. The patient and ophthalmologist reported high satisfaction with anesthesia management. LESSONS: Dexmedetomidine-based monitored conscious sedation with local anesthesia is a feasible alternative to general anesthesia for levator resection in collaborative patients.
[Mh] Termos MeSH primário: Blefaroptose/diagnóstico
Blefaroptose/terapia
Dexmedetomidina/administração & dosagem
Cardiopatias Congênitas/diagnóstico
Cardiopatias Congênitas/terapia
Anormalidades Maxilomandibulares/diagnóstico
Anormalidades Maxilomandibulares/terapia
Monitorização Fisiológica/métodos
Doenças do Sistema Nervoso/diagnóstico
Doenças do Sistema Nervoso/terapia
Músculos Oculomotores/cirurgia
[Mh] Termos MeSH secundário: Anestesia Local
Criança
Sedação Consciente/métodos
Seguimentos
Seres Humanos
Masculino
Doenças Raras
Reflexo Anormal
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
67VB76HONO (Dexmedetomidine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009369


  2 / 4437 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29243902
[Au] Autor:Tyurenkov IN; Perfilova VN; Lashhenova LI; Zhakupova GA; Lebedeva SA
[Ti] Título:Comparison of physical development and rate of formation sensory-motor reflexes offspring of rats with different experimental model of preeclampsia.
[So] Source:Patol Fiziol Eksp Ter;60(3):10-7, 2016 Jul-Sep.
[Is] ISSN:0031-2991
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:Summary: A comparative study of the physical development and the rate of formation of sensory-motor reflexes offspring of rats with experimental preeclampsia (EP) was carried out. In the first experimental group EP was modeled intraperitoneal conduct of L-NAME at a dose of 25 mg/kg from 14 to 21 days of gestation, the second experimental group - the replacement of drinking water by 1.8% sodium chloride solution for the entire period of gestation. In the offspring of both groups, there was a delay of physical development, which was reflected in the later timing of the hair coat development, incisor eruption, pinna detachment as compared to the pups in the control group. It also noted the gap in the formation of sensory-motor reflexes and vestibular reactions. This was manifested in the delayed appearance of the olfactory response, auditory sensitivity, later performing tests «righting reflex¼, «negative geotaxis¼, «aerial righting reflex¼, «cliff avoidance¼, «horizontal wire test¼, «raising the head and forelegs¼, «supporting their bodies on hind legs¼ as compared to the indices of the pups of the female rats with an uncomplicated pregnancy. The most pronounced lag in postnatal development was observed in the offspring of rats with EP, which instead of drinking water was prepared 1.8% sodium chloride during the entire period of gestation. The purpose: To make a comparative study of the impact of ADMA-like preeclampsia (PE) and preeclampsia modeled by the replacement of drinking water consumed by female rats during gestation with 1.8% NaCl solution on the physical development and the rate of the maturation of sensory motor reflexes of their offspring. Methods: The study was performed on three groups of pregnant female rats aged 3-4 months whose original weight was 210-250 g and their pups. They were divided into three groups: 1: Control group including female rats with an uncomplicated pregnancy (n = 6) and their pups (n = 49); 2. Experimental group 1 - pregnant female rats with PE (n = 6) induced by intraabdominal introduction of L-NAME at a dose of 25 mg/kg from 14 to 21 day of gestation (ADMA-like preeclampsia) and their offspring (n = 35); 3. Experimental group 2 - pregnant female rats with PE (n = 6) modeled by the replacement of drinking throughout gestation with 1.8% NaCl solution and their pups. When studying the physical development of the pups we considered the terms of pinna detachment, hair coat development, incisor eruption and the time when they began to open their eyes. To estimate the rate of the maturation of sensory motor reflexes and motor coordination of the pups of the rats with PE we analyzed the time when they started to support their bodies on hind legs, lift their bodies off the floor, crawl, raise their head and forelegs, show the aerial righting reflex and the righting reflex, negative geotaxis, reactions to auditory and olfactory stimuli as well as the time they managed to stay on the horizontal wire. Results: The pups of the female rats with PE of both experimental groups were found to have later pinna detachment, incisor eruption and hair coat development as compared to the indices of the control group. In addition, the offspring of the experimental groups demonstrated a delay in the performance of the following tests: «righting reflex¼, «negative geotaxis¼, «aerial righting reflex¼, «cliff avoidance¼, «horizontal wire test¼, «raising the head and forelegs¼, «supporting their bodies on hind legs¼, «reaction to an olfactory stimulus¼ and «reaction to an auditory stimulus¼ as compared to the indices of the pups of the female rats with an uncomplicated pregnancy. Conclusion: PE induced by the introduction of ADMA to pregnant female rats and by the replacement of drinking water consumed by female rats during gestation with 1.8% NaCl solution causes a delay in physical development, maturation of sensory motor reflexes and vestibular reactions in their offspring.
[Mh] Termos MeSH primário: NG-Nitroarginina Metil Éster/efeitos adversos
Pré-Eclâmpsia/induzido quimicamente
Efeitos Tardios da Exposição Pré-Natal/fisiopatologia
Reflexo Anormal/efeitos dos fármacos
Córtex Sensório-Motor/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Feminino
NG-Nitroarginina Metil Éster/farmacologia
Pré-Eclâmpsia/metabolismo
Pré-Eclâmpsia/fisiopatologia
Gravidez
Efeitos Tardios da Exposição Pré-Natal/induzido quimicamente
Efeitos Tardios da Exposição Pré-Natal/patologia
Ratos
Córtex Sensório-Motor/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
V55S2QJN2X (NG-Nitroarginine Methyl Ester)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE


  3 / 4437 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29287866
[Au] Autor:Paquay S; Wiame E; Deggouj N; Boschi A; De Siati RD; Sznajer Y; Nassogne MC
[Ad] Endereço:Pediatric Neurology Unit, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium. Electronic address: stephanie.paquay@uclouvain.be.
[Ti] Título:Childhood hearing loss is a key feature of CAPOS syndrome: A case report.
[So] Source:Int J Pediatr Otorhinolaryngol;104:191-194, 2018 Jan.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:CAPOS syndrome (cerebellar ataxia, areflexia, pes cavus, optic atrophy, and sensorineural hearing loss) is a rare neurological disorder, recently associated with the c.2452G > A hotspot mutation in the ATP1A3 gene, with sensorineural hearing loss as a prominent feature. We herein report on a girl who has experienced hearing loss for three years following an initial encephalitic episode when aged 15 months old. CAPOS was diagnosed only when she was six years old by targeted testing whilst she displayed optic atrophy, cerebellar signs and areflexia. CAPOS syndrome should be considered in the differential diagnosis of acquired childhood deafness, prompting clinicians to search for associated neurological features.
[Mh] Termos MeSH primário: Ataxia Cerebelar/diagnóstico
Deformidades Congênitas do Pé/diagnóstico
Perda Auditiva Neurossensorial/etiologia
Atrofia Óptica/diagnóstico
[Mh] Termos MeSH secundário: Ataxia Cerebelar/complicações
Criança
Diagnóstico Diferencial
Feminino
Deformidades Congênitas do Pé/complicações
Perda Auditiva Neurossensorial/complicações
Perda Auditiva Neurossensorial/diagnóstico
Testes Auditivos
Seres Humanos
Mutação
Atrofia Óptica/complicações
Reflexo Anormal
ATPase Trocadora de Sódio-Potássio/genética
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.6.3.9 (ATP1A3 protein, human); EC 3.6.3.9 (Sodium-Potassium-Exchanging ATPase)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171231
[St] Status:MEDLINE


  4 / 4437 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29019905
[Au] Autor:Yuan KM; Fu SY; Li J; Shangguan WN; Lian QQ
[Ad] Endereço:Department of Anesthesiology and Perioperative Medicine, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
[Ti] Título:Bezold-Jarisch reflex occurred in a pediatric patient with giant intra-abdominal teratoma during induction of anesthesia: A case report.
[So] Source:Medicine (Baltimore);96(41):e8304, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Bezold-Jarisch reflex (BJR) occurs when the cardioinhibitory receptors in the walls of ventricles are activated by various stimuli, with typical features of bradycardia, vasorelaxation, and hypotension. This reflex usually happens in parturient intrathecal anesthesia, as a result of decreased venous return by compression of inferior vena cava, but it is only rarely reported during general anesthesia. PATIENT CONCERNS: Severe bradycardia and hypotension, indicating BJR, occurred during the induction of general anesthesia in a 3-month-old female child with giant intra-abdominal teratoma. DIAGNOSES: A giant intra-abdominal teratoma was detected by computed tomography scanning. The decreased left ventricular ejection faction along with increased troponin I and N-terminal pro-B-type natriuretic peptide indicated a preoperative mild cardiac dysfunction. BJR was diagnosed on the basis of the severe bradycardia and hypotension observed during the induction of general anesthesia, INTERVENTIONS:: Atropine failed to increase heart rate. Cardiopulmonary resuscitation was initiated immediately and epinephrine was injected intravenously because of sudden circulatory collapse. Soon after the return of spontaneous circulation, a central venous line was placed and invasive blood pressure was monitored. Vital signs and homeostasis were kept stable during teratoma resection. OUTCOMES: The child was extubated after emergence from anesthesia in the operating room. Eleven days later, she had recovered without complications and was discharged. LESSONS: General anesthesia should be induced with great care in patients with giant intra-abdominal masses, and the patient should be kept in the left-lateral table tilt position before induction.
[Mh] Termos MeSH primário: Neoplasias Abdominais
Bradicardia
Dissecação/métodos
Hipotensão
Teratoma
Vasodilatação/fisiologia
[Mh] Termos MeSH secundário: Neoplasias Abdominais/patologia
Neoplasias Abdominais/fisiopatologia
Neoplasias Abdominais/cirurgia
Bradicardia/diagnóstico
Bradicardia/etiologia
Reanimação Cardiopulmonar/métodos
Feminino
Seres Humanos
Hipotensão/diagnóstico
Hipotensão/etiologia
Lactente
Peptídeo Natriurético Encefálico/análise
Fragmentos de Peptídeos/análise
Reflexo Anormal
Volume Sistólico
Teratoma/patologia
Teratoma/fisiopatologia
Teratoma/cirurgia
Tomografia Computadorizada por Raios X/métodos
Resultado do Tratamento
Troponina I/análise
Carga Tumoral
Disfunção Ventricular Esquerda/diagnóstico
Disfunção Ventricular Esquerda/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Peptide Fragments); 0 (Troponin I); 0 (pro-brain natriuretic peptide (1-76)); 114471-18-0 (Natriuretic Peptide, Brain)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171012
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008304


  5 / 4437 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28778915
[Au] Autor:Grotle AK; Garcia EA; Huo Y; Stone AJ
[Ad] Endereço:Department of Kinesiology and Health Education, The University of Texas at Austin, Austin Texas.
[Ti] Título:Temporal changes in the exercise pressor reflex in type 1 diabetic rats.
[So] Source:Am J Physiol Heart Circ Physiol;313(4):H708-H714, 2017 Oct 01.
[Is] ISSN:1522-1539
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Previous studies have shown that diabetic peripheral neuropathy affects both unmyelinated and myelinated afferents, similar to those evoking the exercise pressor reflex. However, the effect of type 1 diabetes (T1DM) on this reflex is not known. We examined, in decerebrate male and female T1DM [streptozotocin (STZ)] and healthy control (CTL) rats, pressor and cardioaccelerator responses to isometric contraction of the hindlimb muscles during the early and late stages of the disease. STZ (50 mg/kg) was injected to induce diabetes, and experiments were conducted at 1, 3, and 6 wk after injection. On the day of the experiment, we statically contracted the hindlimb muscles by stimulating the sciatic nerve and measured changes in mean arterial pressure and heart rate. We found that the pressor but not cardioaccelerator response was exaggerated in STZ rats at 1 wk (STZ: 21 ± 3 mmHg, = 10, and CTL: 14 ± 2 mmHg, = 10, < 0.05) and at 3 wk (STZ: 26 ± 5 mmHg, = 10, and CTL: 17 ± 3 mmHg, = 11, < 0.05) after injection. However, at 6 wk, and only in male rats, both the pressor (STZ: 13 ± 3 mmHg, = 12, and CTL: 17 ± 3 mmHg, = 13, < 0.05) and cardioaccelerator responses (STZ: 7 ± 3 beats/min, = 12, and CTL: 10 ± 3 beats/min, = 13, < 0.05) to contraction were significantly attenuated in STZ rats compared with CTL rats. These data indicate that T1DM exaggerates the exercise pressor reflex during the early stages of the disease in both male and female rats. Conversely, T1DM attenuates this reflex in the late stage of the disease in male but not female rats. This is the first study to provide evidence that the pressor and cardioaccelerator responses to skeletal muscle contraction vary depending on the duration of type 1 diabetes.
[Mh] Termos MeSH primário: Pressão Arterial/fisiologia
Diabetes Mellitus Experimental/fisiopatologia
Diabetes Mellitus Tipo 1/fisiopatologia
Frequência Cardíaca/fisiologia
Condicionamento Físico Animal
Reflexo Anormal/fisiologia
Vasoconstrição/fisiologia
[Mh] Termos MeSH secundário: Animais
Estudos de Casos e Controles
Estado de Descerebração
Estimulação Elétrica
Feminino
Membro Posterior
Masculino
Contração Muscular/fisiologia
Músculo Esquelético
Ratos
Ratos Sprague-Dawley
Reflexo
Nervo Isquiático
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170806
[St] Status:MEDLINE
[do] DOI:10.1152/ajpheart.00399.2017


  6 / 4437 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28778914
[Au] Autor:Tsai CY; Poon YY; Chen CH; Chan SHH
[Ad] Endereço:Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, Republic of China; and.
[Ti] Título:Anomalous baroreflex functionality inherent in floxed and Cre-Lox mice: an overlooked physiological phenotype.
[So] Source:Am J Physiol Heart Circ Physiol;313(4):H700-H707, 2017 Oct 01.
[Is] ISSN:1522-1539
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The last two decades have seen the emergence of Cre-Lox recombination as one of the most powerful and versatile technologies for cell-specific genetic engineering of mammalian cells. Understandably, the primary concerns in the practice of Cre-Lox recombination are whether the predicted genome has been correctly modified and the targeted phenotypes expressed. Rarely are the physiological conditions of the animals routinely examined because the general assumption is that they are normal. Based on corroborative results from radiotelemetric recording, power spectral analysis, and magnetic resonance imaging/diffusion tensor imaging in brain-derived neurotrophic factor-floxed mice, the present study revealed that this assumption requires amendment. We found that despite comparable blood pressure and heart rate with C57BL/6 or Cre mice under the conscious state, floxed and Cre-Lox mice exhibited diminished baroreflex-mediated sympathetic vasomotor tone and cardiac vagal baroreflex. We further found that the capacity and plasticity of baroreflex of these two strains of mice under isoflurane anesthesia were retarded, as reflected by reduced connectivity between the nucleus tractus solitarii and rostral ventrolateral medulla or nucleus ambiguus. The identification of anomalous baroreflex functionality inherent in floxed and Cre-Lox mice points to the importance of incorporating physiological phenotypes into studies that engage gene manipulations such as Cre-Lox recombination. We established that anomalous baroreflex functionality is inherent in floxed and Cre-Lox mice. These two mouse strains exhibited diminished baroreflex-mediated sympathetic vasomotor tone and cardiac vagal baroreflex under the conscious state, retarded capacity and plasticity of baroreflex under isoflurane anesthesia, and reduced connectivity between key nuclei in the baroreflex neural circuits.
[Mh] Termos MeSH primário: Barorreflexo/genética
Pressão Sanguínea/genética
Frequência Cardíaca/genética
Reflexo Anormal/genética
[Mh] Termos MeSH secundário: Anestésicos Inalatórios/farmacologia
Animais
Animais Geneticamente Modificados
Barorreflexo/efeitos dos fármacos
Barorreflexo/fisiologia
Pressão Sanguínea/fisiologia
Fator Neurotrófico Derivado do Encéfalo/genética
Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/genética
Estado de Consciência
Imagem de Tensor de Difusão
Frequência Cardíaca/fisiologia
Integrases
Isoflurano/farmacologia
Imagem por Ressonância Magnética
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Vias Neurais
Fenótipo
Reflexo Anormal/efeitos dos fármacos
Reflexo Anormal/fisiologia
Núcleo Solitário/fisiopatologia
Nervo Vago/fisiopatologia
Sistema Vasomotor
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Inhalation); 0 (Brain-Derived Neurotrophic Factor); CYS9AKD70P (Isoflurane); EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2); EC 2.7.11.17 (Camk2a protein, mouse); EC 2.7.7.- (Cre recombinase); EC 2.7.7.- (Integrases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170806
[St] Status:MEDLINE
[do] DOI:10.1152/ajpheart.00346.2017


  7 / 4437 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28538420
[Au] Autor:Lee DG; Kwak SG; Chang MC
[Ad] Endereço:aDepartment of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University bDepartment of Medical Statistics, College of Medicine, Catholic University of Daegu, Daegu, Republic of Korea.
[Ti] Título:Prediction of the outcome of bladder dysfunction based on electrically induced reflex findings in patients with cauda equina syndrome: A retrospective study.
[So] Source:Medicine (Baltimore);96(21):e7014, 2017 May.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The evaluation of the electrically induced bulbocavernosus reflex (BCR) using electromyography (EMG) is a useful tool for evaluating the integrity of sacral spinal segments 2 to 4, and that of their afferent and efferent connections in the urogenital region. In the current retrospective study, the value of this technique in predicting the outcome of bladder dysfunction was investigated in patients with cauda equina syndrome (CES). Electrically induced BCR (E-BCR) was evaluated in 40 patients with bladder dysfunction due to CES at the subacute stage (7-90 days). Manually examined BCR, perianal pinprick sensation, and voluntary anal contraction were also investigated. The recovery of bladder function was evaluated 1 year after the onset of CES. All patients with the presence of E-BCR showed successful recovery of the bladder function, while all patients in whom E-BCR was absent showed poor recovery. E-BCR showed a higher positive predictive value than perianal pinprick sensation and voluntary anal contraction, and showed a higher negative predictive value than manually examined BCR. Results show that E-BCR has advantages in predicting the outcome of bladder dysfunction. Thus, this method can be used as a reference to predict the final outcome of bladder dysfunction at the subacute stage of CES.
[Mh] Termos MeSH primário: Eletromiografia
Polirradiculopatia/complicações
Reflexo
Doenças da Bexiga Urinária/diagnóstico
Doenças da Bexiga Urinária/fisiopatologia
Bexiga Urinária/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Estimulação Elétrica
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Polirradiculopatia/diagnóstico
Polirradiculopatia/fisiopatologia
Prognóstico
Reflexo/fisiologia
Reflexo Anormal/fisiologia
Estudos Retrospectivos
Doenças da Bexiga Urinária/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170525
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007014


  8 / 4437 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28520722
[Au] Autor:Pritchard S; Jackson MJ; Hikima A; Lione L; Benham CD; Chaudhuri KR; Rose S; Jenner P; Iravani MM
[Ad] Endereço:Department of Pharmacy, Pharmacology and Postgraduate Medicine, University of Hertfordshire, Hatfield, United Kingdom.
[Ti] Título:Altered detrusor contractility in MPTP-treated common marmosets with bladder hyperreflexia.
[So] Source:PLoS One;12(5):e0175797, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bladder hyperreflexia is a common non-motor feature of Parkinson's disease. We now report on the contractility of the isolated primate detrusor strips devoid of nerve input and show that following MPTP, the amplitude and frequency of spontaneous contraction was increased. These responses were unaffected by dopamine D1 and D2 receptor agonists A77636 and ropinirole respectively. Contractions by exogenous carbachol, histamine or ATP were similar and no differences in the magnitude of noradrenaline-induced relaxation were seen in detrusor strip obtained from normal and MPTP-treated common marmosets (Callithrix jacchus). However, the neurogenic contractions following electrical field stimulation of the intrinsic nerves (EFS) were markedly greater in strips obtained from MPTP treated animals. EFS evoked non-cholinergic contractions following atropine were also greater but the contribution of the cholinergic innervation as a proportion of the overall contraction was smaller in the detrusor strips of MPTP treated animals, suggesting a preferential enhancement of the non-cholinergic transmission. Although dopaminergic mechanism has been proposed to underlie bladder hyperreflexia in MPTP-treated animals with intact bladder, the present data indicates that the increased neurogenically mediated contractions where no extrinsic innervation exists might be due to long-term adaptive changes locally as a result of the loss of the nigrostriatal output.
[Mh] Termos MeSH primário: Intoxicação por MPTP/fisiopatologia
Contração Muscular
Reflexo Anormal
Bexiga Urinária/fisiopatologia
[Mh] Termos MeSH secundário: Adamantano/análogos & derivados
Adamantano/farmacologia
Animais
Atropina/farmacologia
Benzopiranos/farmacologia
Callithrix
Fibras Colinérgicas/efeitos dos fármacos
Fibras Colinérgicas/fisiologia
Agonistas de Dopamina/farmacologia
Feminino
Indóis/farmacologia
Masculino
Antagonistas Muscarínicos/farmacologia
Músculo Liso/inervação
Músculo Liso/fisiologia
Bexiga Urinária/efeitos dos fármacos
Bexiga Urinária/inervação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzopyrans); 0 (Dopamine Agonists); 0 (Indoles); 0 (Muscarinic Antagonists); 030PYR8953 (ropinirole); 145307-34-2 (A 77636); 7C0697DR9I (Atropine); PJY633525U (Adamantane)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170519
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0175797


  9 / 4437 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28228416
[Au] Autor:Zhang C; Lin RL; Hong J; Khosravi M; Lee LY
[Ad] Endereço:Department of Physiology, University of Kentucky, Lexington, Kentucky.
[Ti] Título:Cough and expiration reflexes elicited by inhaled irritant gases are intensified in ovalbumin-sensitized mice.
[So] Source:Am J Physiol Regul Integr Comp Physiol;312(5):R718-R726, 2017 May 01.
[Is] ISSN:1522-1490
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study was designed to determine the effect of active sensitization with ovalbumin (Ova) on cough responses to inhaled irritant gases in mice. Conscious mice moved freely in a recording chamber, while the pressure change in the chamber and audio and video signals of the mouse movements were recorded simultaneously to measure the frequencies of cough reflex (CR) and expiration reflex (ER). To further verify the accuracy of cough analysis, the intrapleural pressure was also recorded by a telemetry sensor surgically implanted in the intrapleural space in a subgroup of mice. During the irritant gas inhalation challenge, sulfur dioxide (SO ; 200 and 400 ppm) or ammonia (NH ; 0.1% and 0.2%) was drawn into the chamber at a constant flow rate for 8 min. Ova sensitization and sham sensitization with vehicle (Veh) were performed over a 25-day period in separate groups of mice. Our results showed that ) both SO and NH inhalation challenges increased CR and ER frequencies in a concentration-dependent manner before Ova sensitization; ) the baseline CR frequency was significantly elevated after Ova sensitization, accompanied by pronounced airway inflammation; and ) Ova sensitization also markedly augmented the responses of CR and ER to both SO and NH inhalation challenges; in sharp contrast, the cough responses did not change after sham sensitization in the Veh group. In conclusion, Ova sensitization caused distinct and lingering increases in baseline cough frequency, and also intensified both CR and ER responses to inhaled irritant gases, which probably resulted from an allergic inflammation-induced hypersensitivity of airway sensory nerves.
[Mh] Termos MeSH primário: Tosse/fisiopatologia
Expiração/efeitos dos fármacos
Lesão Pulmonar/induzido quimicamente
Lesão Pulmonar/fisiopatologia
Pneumonia/fisiopatologia
Reflexo/efeitos dos fármacos
Emissões de Veículos/envenenamento
[Mh] Termos MeSH secundário: Administração por Inalação
Amônia/administração & dosagem
Amônia/envenenamento
Animais
Exposição por Inalação/efeitos adversos
Irritantes/administração & dosagem
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Ovalbumina
Pneumonia/induzido quimicamente
Pneumonia/complicações
Reflexo Anormal
Dióxido de Enxofre/administração & dosagem
Dióxido de Enxofre/envenenamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Irritants); 0 (Vehicle Emissions); 0UZA3422Q4 (Sulfur Dioxide); 7664-41-7 (Ammonia); 9006-59-1 (Ovalbumin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170224
[St] Status:MEDLINE
[do] DOI:10.1152/ajpregu.00444.2016


  10 / 4437 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27923188
[Au] Autor:Kuwabara S; Sekiguchi Y; Misawa S
[Ad] Endereço:Department of Neurology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. Electronic address: kuwabara-s@faculty.chiba-u.jp.
[Ti] Título:Electrophysiology in Fisher syndrome.
[So] Source:Clin Neurophysiol;128(1):215-219, 2017 Jan.
[Is] ISSN:1872-8952
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Fisher syndrome (FS), a variant of Guillain-Barré syndrome (GBS), is characterized by the clinical triad of ophthalmoplegia, ataxia, and areflexia. The lesion sites for these unique clinical features include the oculomotor nerves and group 1a neurons in the dorsal root ganglion, and the presence of FS is determined by the expression of ganglioside GQ1b in the human nervous system. Neurophysiological findings suggest that ataxia and areflexia are due to an impaired proprioceptive afferent system. Typically, the soleus H-reflex is absent and a body-sway analysis using posturography shows a 1-Hz peak, which indicates proprioception dysfunction. Sensory nerve action potentials and somatosensory-evoked potentials are abnormal in approximately 30% of FS patients, indicating the occasional involvement of cutaneous (group 2) afferents. During the disease course, approximately 15% of FS patients suffer an overlap of axonal GBS with nerve conduction abnormalities that reflect axonal dysfunction. This review summarizes electrophysiological abnormalities and their clinical significance in FS.
[Mh] Termos MeSH primário: Fenômenos Eletrofisiológicos/fisiologia
Síndrome de Miller Fisher/diagnóstico
Síndrome de Miller Fisher/fisiopatologia
Condução Nervosa/fisiologia
[Mh] Termos MeSH secundário: Ataxia/diagnóstico
Ataxia/fisiopatologia
Potenciais Somatossensoriais Evocados/fisiologia
Reflexo H/fisiologia
Seres Humanos
Nervo Oculomotor/fisiopatologia
Propriocepção/fisiologia
Reflexo Anormal/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161207
[St] Status:MEDLINE



página 1 de 444 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde