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[PMID]:29360871
[Au] Autor:Belqaid K; Tishelman C; Orrevall Y; Månsson-Brahme E; Bernhardson BM
[Ad] Endereço:Medical Management Centre, Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden.
[Ti] Título:Dealing with taste and smell alterations-A qualitative interview study of people treated for lung cancer.
[So] Source:PLoS One;13(1):e0191117, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Taste and smell alterations have been recognized as common symptoms in relation to various cancers. However, previous research suggests that patients do not receive sufficient support in managing taste and smell alterations. Therefore, the objective of this study is to investigate how persons with experience from lung cancer-related taste and smell alterations reason about resources and strategies offered and used to manage these symptoms. Data from semi-structured individual interviews with 13 women and four men were analyzed with qualitative content analysis. We used Kleinman's now classic medical anthropological model of local health care systems, consisting of the personal, professional, and folk sector, to interpret and understand how people respond to sickness experiences in their daily lives. By presenting the findings using this model, we demonstrate that most strategies for dealing with taste and smell alterations were undertaken in the personal sector, i.e. in participants' daily lives, on an individual level and in interaction with family, social networks and communities. Taste and smell alterations implied two overarching challenges: 1) adjusting to no longer being able to trust information provided by one's own senses of taste and/or smell, and 2) coming to terms with taste and smell alterations as a part of having lung cancer. Health care professionals' involvement was described as limited, but appeared to fulfil most participants' expectations. However, through provision of normalizing information, practical advice, and to some extent, emotional support, health care professionals had potential to influence strategies and resources used for dealing with taste and smell alterations. With this study, we further the understanding of how people deal with lung cancer-related taste and smell alterations and discuss the role of health care professionals for this process.
[Mh] Termos MeSH primário: Neoplasias Pulmonares/fisiopatologia
Transtornos do Olfato/terapia
Distúrbios do Paladar/terapia
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Entrevistas como Assunto
Neoplasias Pulmonares/complicações
Masculino
Meia-Idade
Transtornos do Olfato/etiologia
Pesquisa Qualitativa
Distúrbios do Paladar/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180124
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191117


  2 / 3456 MEDLINE  
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[PMID]:28468171
[Au] Autor:Hwang K; Yeom SH; Hwang SH
[Ad] Endereço:*Department of Plastic Surgery, Inha University School of Medicine †Inha University School of Medicine, Incheon, Korea.
[Ti] Título:Complications of Nasal Bone Fractures.
[So] Source:J Craniofac Surg;28(3):803-805, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to perform a systematic review of the treatment of nasal bone fractures. The search terms ("nasal bone fracture" AND complication) and ("nasal bone fracture" AND [anosmia OR olfaction OR olfactory nerve OR smell]) and (anosmia AND ["nasal preparation" OR "nasal antiseptics"]) were used to search PubMed and SCOPUS. Of the 500 titles, 40 full papers were reviewed. One paper was excluded, and 3 mined papers were added. Ultimately, 12 papers were analyzed. The overall deformity rate was 10.4% ±â€Š4.8%. No significant differences were found between patients who underwent closed reduction (14.7% ±â€Š7.3%) and those who underwent open reduction (9.4% ±â€Š4.4%), between those who underwent local anesthesia (5.8% ±â€Š4.5%), and those who underwent general anesthesia (8.8% ±â€Š3.8%), or between those who received timely treatment (5.7%) and those whose treatment was delayed (9.0%). Septal deviation occurred in 10.0% of patients as a sequela of nasal bone fracture. The nasal obstruction rate was 10.5% ±â€Š5.3%. Fewer patients of nasal obstruction occurred in the open reduction patients (6.9% ±â€Š4.4%) than in the closed reduction patients (15.2%). One patient of epiphora and 1 patient of diplopia were reportedAmong the 77 patients with nasal bone fractures, 29 (37.7% ±â€Š11.3%) complained of olfactory disturbances. No significant associations were found between the type of fracture and the presence of olfactory disturbances. It is recommended for providers to explain to patients that approximately one-tenth of nasal bone fractures exhibit deformity, septal deviation, or nasal obstruction after surgery. Surgeons should take considerable care to avoid the olfactory mucosa during reduction surgery.
[Mh] Termos MeSH primário: Osso Nasal/lesões
Obstrução Nasal/etiologia
Deformidades Adquiridas Nasais/etiologia
Transtornos do Olfato/etiologia
Redução Aberta/efeitos adversos
Fraturas Cranianas/cirurgia
[Mh] Termos MeSH secundário: Seres Humanos
Osso Nasal/diagnóstico por imagem
Osso Nasal/cirurgia
Obstrução Nasal/diagnóstico
Deformidades Adquiridas Nasais/diagnóstico
Transtornos do Olfato/diagnóstico
Fraturas Cranianas/diagnóstico
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003482


  3 / 3456 MEDLINE  
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[PMID]:29382018
[Au] Autor:Park JH; Byeon HK; Park KN; Kim JW; Lee SW; Han KD; Chang JW; Kim WS; Koh YW; Ban MJ
[Ad] Endereço:Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Cheonan.
[Ti] Título:Epidemiological association of olfactory dysfunction with hearing loss and dysphonia in the Korean population: A cross-sectional study.
[So] Source:Medicine (Baltimore);96(47):e8890, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of the study is to investigate the association between olfactory dysfunction (OD), hearing loss, and dysphonia.The cross-sectional data for 17,984 adults who completed the Korea National Health and Nutrition Examination Surveys (2010-12) were analyzed. OD, hearing loss, and dysphonia were assessed using self-reporting questionnaires. The association of OD with hearing loss and dysphonia was evaluated.Hearing loss and dysphonia were significantly more prevalent in patients with OD than in those without OD (hearing loss, 28.1% vs 11.3%; dysphonia, 11.1% vs 5.9%; both P < .0001). After adjusting for confounders, including mental stress and metabolic syndrome, the risk of OD was significantly associated with hearing loss and dysphonia, and was greater in those with combined hearing loss and dysphonia than in both patients without these dysfunctions and in those with a single dysfunction (odds ratio 3.115, 95% confidence interval 1.973-4.917).OD was significantly associated with hearing loss and dysphonia.
[Mh] Termos MeSH primário: Disfonia/epidemiologia
Perda Auditiva/epidemiologia
Transtornos do Olfato/epidemiologia
[Mh] Termos MeSH secundário: Estudos Transversais
Disfonia/complicações
Feminino
Perda Auditiva/complicações
Seres Humanos
Masculino
Meia-Idade
Inquéritos Nutricionais
Razão de Chances
Transtornos do Olfato/complicações
Prevalência
República da Coreia/epidemiologia
Autorrelato
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008890


  4 / 3456 MEDLINE  
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[PMID]:29304050
[Au] Autor:Yoneyama N; Watanabe H; Kawabata K; Bagarinao E; Hara K; Tsuboi T; Tanaka Y; Ohdake R; Imai K; Masuda M; Hattori T; Ito M; Atsuta N; Nakamura T; Hirayama M; Maesawa S; Katsuno M; Sobue G
[Ad] Endereço:Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
[Ti] Título:Severe hyposmia and aberrant functional connectivity in cognitively normal Parkinson's disease.
[So] Source:PLoS One;13(1):e0190072, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Severe hyposmia is a risk factor of dementia in Parkinson's disease (PD), while the underlying functional connectivity (FC) and brain volume alterations in PD patients with severe hyposmia (PD-SH) are unclear. METHODS: We examined voxel-based morphometric and resting state functional magnetic resonance imaging findings in 15 cognitively normal PD-SH, 15 cognitively normal patients with PD with no/mild hyposmia (PD-N/MH), and 15 healthy controls (HCs). RESULTS: Decreased gray matter volume (GMV) was observed in the bilateral cuneus, right associative visual area, precuneus, and some areas in anterior temporal lobes in PD-SH group compared to HCs. Both the PD-SH and PD-N/MH groups showed increased GMV in the bilateral posterior insula and its surrounding regions. A widespread significant decrease in amygdala FC beyond the decreased GMV areas and olfactory cortices were found in the PD-SH group compared with the HCs. Above all, decreased amygdala FC with the inferior parietal lobule, lingual gyrus, and fusiform gyrus was significantly correlated with both reduction of Addenbrooke's Cognitive Examination-Revised scores and severity of hyposmia in all participants. Canonical resting state networks exhibited decreased FC in the precuneus and left executive control networks but increased FC in the primary and high visual networks of patients with PD compared with HCs. Canonical network FC to other brain regions was enhanced in the executive control, salience, primary visual, and visuospatial networks of the PD-SH. CONCLUSION: PD-SH showed extensive decreased amygdala FC. Particularly, decreased FC between the amygdala and inferior parietal lobule, lingual gyrus, and fusiform gyrus were associated with the severity of hyposmia and cognitive performance. In contrast, relatively preserved canonical networks in combination with increased FC to brain regions outside of canonical networks may be related to compensatory mechanisms, and preservation of brain function.
[Mh] Termos MeSH primário: Mapeamento Encefálico/métodos
Cognição
Transtornos do Olfato/fisiopatologia
Doença de Parkinson/fisiopatologia
[Mh] Termos MeSH secundário: Idoso
Feminino
Substância Cinzenta/diagnóstico por imagem
Substância Cinzenta/fisiopatologia
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Doença de Parkinson/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190072


  5 / 3456 MEDLINE  
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[PMID]:28882981
[Au] Autor:Bonomi M; Vezzoli V; Krausz C; Guizzardi F; Vezzani S; Simoni M; Bassi I; Duminuco P; Di Iorgi N; Giavoli C; Pizzocaro A; Russo G; Moro M; Fatti L; Ferlin A; Mazzanti L; Zatelli MC; Cannavò S; Isidori AM; Pincelli AI; Prodam F; Mancini A; Limone P; Tanda ML; Gaudino R; Salerno M; Francesca P; Maghnie M; Maggi M; Persani L; Italian Network on Central Hypogonadism
[Ad] Endereço:Department of Clinical Sciences and Community HealthUniversity of Milan, Milan, Italy m.bonomi@auxologico.it marco.bonomi@unimi.it.
[Ti] Título:Characteristics of a nationwide cohort of patients presenting with isolated hypogonadotropic hypogonadism (IHH).
[So] Source:Eur J Endocrinol;178(1):23-32, 2018 Jan.
[Is] ISSN:1479-683X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Isolated hypogonadotropic hypogonadism (IHH) is a rare disorder with pubertal delay, normal (normoosmic-IHH, nIHH) or defective sense of smell (Kallmann syndrome, KS). Other reproductive and non-reproductive anomalies might be present although information on their frequency are scanty, particularly according to the age of presentation. DESIGN: Observational cohort study carried out between January 2008 and June 2016 within a national network of academic or general hospitals. METHODS: We performed a detailed phenotyping of 503 IHH patients with: (1) manifestations of hypogonadism with low sex steroid hormone and low/normal gonadotropins; (2) absence of expansive hypothalamic/pituitary lesions or multiple pituitary hormone defects. Cohort was divided on IHH onset (PPO, pre-pubertal onset or AO, adult onset) and olfactory function: PPO-nIHH ( = 275), KS ( = 184), AO-nIHH ( = 36) and AO-doIHH (AO-IHH with defective olfaction, = 8). RESULTS: 90% of patients were classified as PPO and 10% as AO. Typical midline and olfactory defects, bimanual synkinesis and familiarity for pubertal delay were also found among the AO-IHH. Mean age at diagnosis was significantly earlier and more frequently associated with congenital hypogonadism stigmata in patients with Kallmann's syndrome (KS). Synkinesis, renal and male genital tract anomalies were enriched in KS. Overweight/obesity are significantly associated with AO-IHH rather than PPO-IHH. CONCLUSIONS: Patients with KS are more prone to develop a severe and complex phenotype than nIHH. The presence of typical extra-gonadal defects and familiarity for PPO-IHH among the AO-IHH patients indicates a common predisposition with variable clinical expression. Overall, these findings improve the understanding of IHH and may have a positive impact on the management of patients and their families.
[Mh] Termos MeSH primário: Hipogonadismo/fisiopatologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idade de Início
Estudos de Coortes
Feminino
Hormônios Esteroides Gonadais/sangue
Gonadotropinas/sangue
Gonadotropinas/deficiência
Seres Humanos
Hipogonadismo/diagnóstico por imagem
Hipogonadismo/epidemiologia
Itália/epidemiologia
Masculino
Obesidade/complicações
Obesidade/epidemiologia
Transtornos do Olfato/complicações
Transtornos do Olfato/epidemiologia
Sobrepeso/complicações
Sobrepeso/epidemiologia
Fenótipo
Hormônios Hipofisários/sangue
Hormônios Hipofisários/deficiência
Sincinesia/complicações
Sincinesia/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Gonadal Steroid Hormones); 0 (Gonadotropins); 0 (Pituitary Hormones)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171129
[Lr] Data última revisão:
171129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1530/EJE-17-0065


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[PMID]:29016623
[Au] Autor:Schriever VA; Han P; Weise S; Hösel F; Pellegrino R; Hummel T
[Ad] Endereço:Smell & Taste Clinic, Department of Otorhinolaryngology, Technical University of Dresden, Dresden, Germany.
[Ti] Título:Time frequency analysis of olfactory induced EEG-power change.
[So] Source:PLoS One;12(10):e0185596, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The objective of the present study was to investigate the usefulness of time-frequency analysis (TFA) of olfactory-induced EEG change with a low-cost, portable olfactometer in the clinical investigation of smell function. MATERIALS & METHODS: A total of 78 volunteers participated. The study was composed of three parts where olfactory stimuli were presented using a custom-built olfactometer. Part I was designed to optimize the stimulus as well as the recording conditions. In part II EEG-power changes after olfactory/trigeminal stimulation were compared between healthy participants and patients with olfactory impairment. In Part III the test-retest reliability of the method was evaluated in healthy subjects. RESULTS: Part I indicated that the most effective paradigm for stimulus presentation was cued stimulus, with an interstimulus interval of 18-20s at a stimulus duration of 1000ms with each stimulus quality presented 60 times in blocks of 20 stimuli each. In Part II we found that central processing of olfactory stimuli analyzed by TFA differed significantly between healthy controls and patients even when controlling for age. It was possible to reliably distinguish patients with olfactory impairment from healthy individuals at a high degree of accuracy (healthy controls vs anosmic patients: sensitivity 75%; specificity 89%). In addition we could show a good test-retest reliability of TFA of chemosensory induced EEG-power changes in Part III. CONCLUSIONS: Central processing of olfactory stimuli analyzed by TFA reliably distinguishes patients with olfactory impairment from healthy individuals at a high degree of accuracy. Importantly this can be achieved with a simple olfactometer.
[Mh] Termos MeSH primário: Eletroencefalografia/métodos
Transtornos do Olfato/diagnóstico
Olfatometria/métodos
Percepção Olfatória/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Estudos de Casos e Controles
Sinais (Psicologia)
Cicloexanóis/análise
Eletroencefalografia/instrumentação
Feminino
Voluntários Saudáveis
Seres Humanos
Masculino
Meia-Idade
Monoterpenos/análise
Transtornos do Olfato/fisiopatologia
Olfatometria/instrumentação
Álcool Feniletílico/análise
Sensibilidade e Especificidade
Olfato/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclohexanols); 0 (Monoterpenes); ML9LGA7468 (Phenylethyl Alcohol); RV6J6604TK (eucalyptol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171011
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185596


  7 / 3456 MEDLINE  
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[PMID]:28969383
[Au] Autor:Zapiec B; Dieriks BV; Tan S; Faull RLM; Mombaerts P; Curtis MA
[Ad] Endereço:Max Planck Research Unit for Neurogenetics, Frankfurt, Germany.
[Ti] Título:A ventral glomerular deficit in Parkinson's disease revealed by whole olfactory bulb reconstruction.
[So] Source:Brain;140(10):2722-2736, 2017 Oct 01.
[Is] ISSN:1460-2156
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Olfactory dysfunction is common in Parkinson's disease and is an early symptom, but its pathogenesis remains poorly understood. Hindering progress in our mechanistic understanding of olfactory dysfunction in Parkinson's disease is the paucity of literature about the human olfactory bulb, both from normal and Parkinson's disease cases. Qualitatively it is well established that the neat arrangement of the glomerular array seen in the mouse olfactory bulb is missing in humans. But rigorous quantitative approaches to describe and compare the thousands of glomeruli in the human olfactory bulb are not available. Here we report a quantitative approach to describe the glomerular component of the human olfactory bulb, and its application to draw statistical comparisons between olfactory bulbs from normal and Parkinson's disease cases. We subjected horizontal 10 µm sections of olfactory bulbs from six normal and five Parkinson's disease cases to fluorescence immunohistochemistry with antibodies against vesicular glutamate transporter-2 and neural cell adhesion molecule. We scanned the immunostained sections with a fluorescence slide scanner, segmented the glomeruli, and generated 3D reconstructions of whole olfactory bulbs. We document the occurrence of atypical glomerular morphologies and glomerular-like structures deep in the olfactory bulb, both in normal and Parkinson's disease cases. We define a novel and objective parameter: the global glomerular voxel volume, which is the total volume of all voxels that are classified immunohistochemically as glomerular. We find that the global glomerular voxel volume in Parkinson's disease cases is half that of normal cases. The distribution of glomerular voxels along the dorsal-ventral dimension of the olfactory bulb in these series of horizontal sections is significantly altered in Parkinson's disease cases: whereas most glomerular voxels reside within the ventral half of olfactory bulbs from normal cases, glomerular voxels are more evenly spread among the ventral and dorsal halves of olfactory bulbs from Parkinson's disease cases. These quantitative whole-olfactory bulb analyses indicate a predominantly ventral deficit in the glomerular component in Parkinson's disease, consistent with the olfactory vector hypothesis for the pathogenesis of this neurodegenerative disease. The distribution of serine 129-phosphorylated α-synuclein immunoreactive voxels correlates with that of glomerular voxels. The higher the serine 129-phosphorylated α-synuclein load of an olfactory bulb from a Parkinson's disease case, the lower the global glomerular voxel volume. Our rigorous quantitative approach to the whole olfactory bulb will help understand the anatomy and histology of the normal human olfactory bulb and its pathological alterations in Parkinson's disease.
[Mh] Termos MeSH primário: Transtornos do Olfato/etiologia
Bulbo Olfatório/patologia
Doença de Parkinson/complicações
Doença de Parkinson/patologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Imunofluorescência
Seres Humanos
Processamento de Imagem Assistida por Computador
Masculino
Meia-Idade
Moléculas de Adesão de Célula Nervosa/metabolismo
Bulbo Olfatório/metabolismo
Tirosina 3-Mono-Oxigenase
Proteína Vesicular 2 de Transporte de Glutamato/metabolismo
alfa-Sinucleína/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neural Cell Adhesion Molecules); 0 (Vesicular Glutamate Transport Protein 2); 0 (alpha-Synuclein); EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE
[do] DOI:10.1093/brain/awx208


  8 / 3456 MEDLINE  
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[PMID]:28882322
[Au] Autor:Rodríguez-Violante M; Zerón-Martínez R; Cervantes-Arriaga A; Corona T
[Ad] Endereço:Unidad de Investigación de Enfermedades Neurodegenerativas Clínicas, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México; Clínica de Trastornos del Movimiento, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.
[Ti] Título:Who Can Diagnose Parkinson's Disease First? Role of Pre-motor Symptoms.
[So] Source:Arch Med Res;48(3):221-227, 2017 Apr.
[Is] ISSN:1873-5487
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In 1817, James Parkinson described the disease which bears his name. The disease was defined as a neurological syndrome characterized by tremor, rigidity, and slowness of movements. Almost one hundred years later, degeneration of neurons in the substantia nigra and low levels of dopamine were identified as the putative cause of the disease, thus the disease remained as a pure neurological disorder. In the late 1990s, non-motor symptoms of the disease began to gain interest because of their clinical relevance, as well as for their potential role in broadening the understanding of the pathophysiological mechanisms involved. In the last decade, focus has shifted to the pre-motor symptoms, those non-motor symptoms that present years before the motor onset of the disease. The main premotor symptoms include rapid eye movement sleep behavior disorder, hyposmia, constipation and depression. Subjects with these symptoms usually are not initially seen by a neurologist, and by the time they are consulted neuronal loss in the substantia nigra is over 50%. This review summarizes the overall relevance of non-motor symptoms, their frequency and their pathophysiological implications. Also, the importance of pre-motor symptoms, and the role of specialists other than neurologists in diagnosing subjects with Parkinson's disease is discussed. Two hundred years after the first description of the disease, it is now evident that Parkinson's disease is a systemic disease and a multispecialty team approach is mandatory.
[Mh] Termos MeSH primário: Doença de Parkinson/diagnóstico
[Mh] Termos MeSH secundário: Constipação Intestinal/diagnóstico
Depressão/diagnóstico
Diagnóstico Precoce
Seres Humanos
Transtornos do Olfato/diagnóstico
Doença de Parkinson/fisiopatologia
Doença de Parkinson/psicologia
Transtornos do Sono-Vigília/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE


  9 / 3456 MEDLINE  
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[PMID]:28864676
[Au] Autor:Searles Nielsen S; Warden MN; Camacho-Soto A; Willis AW; Wright BA; Racette BA
[Ad] Endereço:From the Department of Neurology (S.S.N., M.N.W., A.C.-S., B.A.W., B.A.R.), Washington University School of Medicine, St. Louis, MO; Departments of Neurology and Biostatistics and Epidemiology (A.W.W.), University of Pennsylvania School of Medicine, Philadelphia; and School of Public Health, Faculty
[Ti] Título:A predictive model to identify Parkinson disease from administrative claims data.
[So] Source:Neurology;89(14):1448-1456, 2017 Oct 03.
[Is] ISSN:1526-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To use administrative medical claims data to identify patients with incident Parkinson disease (PD) prior to diagnosis. METHODS: Using a population-based case-control study of incident PD in 2009 among Medicare beneficiaries aged 66-90 years (89,790 cases, 118,095 controls) and the elastic net algorithm, we developed a cross-validated model for predicting PD using only demographic data and 2004-2009 Medicare claims data. We then compared this model to more basic models containing only demographic data and diagnosis codes for constipation, taste/smell disturbance, and REM sleep behavior disorder, using each model's receiver operator characteristic area under the curve (AUC). RESULTS: We observed all established associations between PD and age, sex, race/ethnicity, tobacco smoking, and the above medical conditions. A model with those predictors had an AUC of only 0.670 (95% confidence interval [CI] 0.668-0.673). In contrast, the AUC for a predictive model with 536 diagnosis and procedure codes was 0.857 (95% CI 0.855-0.859). At the optimal cut point, sensitivity was 73.5% and specificity was 83.2%. CONCLUSIONS: Using only demographic data and selected diagnosis and procedure codes readily available in administrative claims data, it is possible to identify individuals with a high probability of eventually being diagnosed with PD.
[Mh] Termos MeSH primário: Medicare/estatística & dados numéricos
Doença de Parkinson/diagnóstico
Doença de Parkinson/epidemiologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Estudos de Casos e Controles
Feminino
Seres Humanos
Masculino
Transtornos do Olfato/etiologia
Doença de Parkinson/complicações
Valor Preditivo dos Testes
Curva ROC
Estudos Retrospectivos
Transtornos do Sono-Vigília/etiologia
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170903
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000004536


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[PMID]:28802362
[Au] Autor:Dzaman K; Zborowska-Piskadlo K; Pietniczka-Zaleska M; Kantor I
[Ad] Endereço:Department of Otolaryngology, Centre of Postgraduate Medical Education, 8 Kondratowicza St., 03-242 Warsaw, Poland; Department of Otolaryngology, Miedzyleski Hospital, 2 Bursztynowa St., 04-749 Warsaw, Poland. Electronic address: kfrydel@poczta.onet.pl.
[Ti] Título:Kallmann syndrome in pediatric otorhinolaryngology practice - Case report and literature review.
[So] Source:Int J Pediatr Otorhinolaryngol;100:149-153, 2017 Sep.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Kallmann syndrome (KS) is an isolated form of hypogonadotrophic hypogonadism (HH) in combination with a defect in olfactory function. The diagnosis of KS before maturation is often difficult to make due to the broad spectrum of presentation and genetic heterogeneities. ENT examination including smell test is essential for proper diagnosis of olfactory disturbances and non olfactory abnormalities in craniofacial region which may also be existent in KS. CASE: A 17-year-old girl admitted to ENT Department because of the olfactory sense disturbances since two years. The patient reported also amenorrhea caused by primary HH. A diagnostic work-up using double-checked Sniffin' Sticks test and 6-items olfactory test confirmed serious hyposmia and identified the presence of KS. CONCLUSION: Usually anosmia is not recognized by the affected individuals, so it is recommended to perform olfactory screening tests and obligatory ENT examination in the event of a HH even when patient reports a normal sense of smell. It leads to early diagnosis of KS and will benefit the relevant patient care.The KS diagnosis should be done at an early stage, but symptoms and clinical manifestations are not always evident both in ENT and pediatric field. In this article we would like to highlight the need for a multidisciplinary assessment and awareness for KS symptoms in pediatric practice as a hole.
[Mh] Termos MeSH primário: Síndrome de Kallmann/diagnóstico
Transtornos do Olfato/etiologia
[Mh] Termos MeSH secundário: Adolescente
Criança
Feminino
Seres Humanos
Hipogonadismo/etiologia
Síndrome de Kallmann/complicações
Transtornos do Olfato/diagnóstico
Otolaringologia
Olfato
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170814
[St] Status:MEDLINE



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