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[PMID]:28468199
[Au] Autor:Cho SE; Shin HS; Tak MS; Kang SG; Lee YS; Kim HS; Kim CH
[Ad] Endereço:*Department of Plastic and Reconstructive Surgery, College of Medicine, Soonchunhyang University Seoul Hospital, Seoul †Department of Plastic and Reconstructive Surgery, College of Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.
[Ti] Título:A Rare Complication of Infraorbital Nerve Hyperesthesia in Surgically Repaired Orbital Fracture Patients.
[So] Source:J Craniofac Surg;28(3):e233-e234, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Injury to the peripheral sensory branches of the trigeminal nerve can follow a wide variety of craniofacial injuries. Many patients with facial fractures complain about the symptom of numbness to the distribution of injured nerve, which is indicative of hypoesthesia. Hyperesthesia involving the infraorbital nerve is rare in comparison to hypoesthesia secondary to facial trauma. The authors report on 2 patients with infraorbital nerve hyperesthesia in surgically repaired orbital fracture patients. Surgical decompression of the infraorbital nerve led to rapid resolution of hyperesthesia. To the best of our knowledge, these were rare cases of patients who presented with persistent hyperesthesia. Clinician should perform early surgical decompression of the infraorbital nerve in patient with persistent hyperesthesia of the infraorbital nerve.
[Mh] Termos MeSH primário: Hiperestesia/etiologia
Nervo Maxilar/lesões
Fraturas Orbitárias/complicações
Fraturas Orbitárias/cirurgia
[Mh] Termos MeSH secundário: Adulto
Descompressão Cirúrgica
Seres Humanos
Hiperestesia/diagnóstico
Hiperestesia/cirurgia
Hipestesia/etiologia
Hipestesia/cirurgia
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003439


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[PMID]:27434229
[Au] Autor:Reynolds WS; Brown ET; Danford J; Kaufman M; Wein A; Dmochowski R; Bruehl S
[Ad] Endereço:Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
[Ti] Título:Temporal summation to thermal stimuli is elevated in women with overactive bladder syndrome.
[So] Source:Neurourol Urodyn;36(4):1108-1112, 2017 04.
[Is] ISSN:1520-6777
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: This study sought to provide a preliminary assessment of whether spinally mediated afferent hyperactivity (i.e., central sensitization) might contribute to manifestations of overactive bladder syndrome (OAB) in women as indexed by elevated temporal summation of evoked heat pain stimuli. METHODS: We recruited 20 adult women with OAB who were planning to undergo interventional therapy for OAB with either onabotulinumtoxinA injection or sacral neuromodulation and 23 healthy controls without OAB symptoms to undergo quantitative sensory testing with cutaneous thermal pain temporal summation. The primary study outcome was the degree of temporal summation, as reflected in the magnitude of positive slope of the line fitted to the series of 10 stimuli at the 49°C target temperatures. Linear regression and analysis of covariance were utilized to compare the degree of temporal summation between study groups. RESULTS: The standardized slope of temporal summation trials for women with OAB was significantly higher than for controls (ß = 3.43, 95% confidence interval = 0.6-6.2, P = 0.017). The adjusted means ±SE of the standardized temporal summation slopes for the full OAB and control groups were 3.0 ± 0.5 (95% confidence interval = 2.0, 4.1) and 1.7 ± 0.5 (95% confidence interval = 0.7, 2.7), respectively. CONCLUSION: In this preliminary study, we demonstrated that women with OAB refractory to primary and secondary therapies exhibited greater thermal cutaneous temporal summation than women without OAB symptoms. This suggests that central sensitization, indexed by temporal summation, may be an underlying factor contributing to OAB in some women. Neurourol. Urodynam. 36:1108-1112, 2017. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Sensibilização do Sistema Nervoso Central/fisiologia
Hiperestesia/fisiopatologia
Percepção da Dor/fisiologia
Bexiga Urinária Hiperativa/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Vias Aferentes/fisiopatologia
Idoso
Feminino
Temperatura Alta
Seres Humanos
Meia-Idade
Dor/fisiopatologia
Medição da Dor
Limiar da Dor
Bexiga Urinária Hiperativa/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160720
[St] Status:MEDLINE
[do] DOI:10.1002/nau.23059


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[PMID]:27840000
[Au] Autor:Yarmolinsky DA; Peng Y; Pogorzala LA; Rutlin M; Hoon MA; Zuker CS
[Ad] Endereço:Howard Hughes Medical Institute and Departments of Biochemistry and Molecular Biophysics and Neuroscience, Columbia College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
[Ti] Título:Coding and Plasticity in the Mammalian Thermosensory System.
[So] Source:Neuron;92(5):1079-1092, 2016 Dec 07.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Perception of the thermal environment begins with the activation of peripheral thermosensory neurons innervating the body surface. To understand how temperature is represented in vivo, we used genetically encoded calcium indicators to measure temperature-evoked responses in hundreds of neurons across the trigeminal ganglion. Our results show how warm, hot, and cold stimuli are represented by distinct population responses, uncover unique functional classes of thermosensory neurons mediating heat and cold sensing, and reveal the molecular logic for peripheral warmth sensing. Next, we examined how the peripheral somatosensory system is functionally reorganized to produce altered perception of the thermal environment after injury. We identify fundamental transformations in sensory coding, including the silencing and recruitment of large ensembles of neurons, providing a cellular basis for perceptual changes in temperature sensing, including heat hypersensitivity, persistence of heat perception, cold hyperalgesia, and cold analgesia.
[Mh] Termos MeSH primário: Queimaduras/metabolismo
Hiperalgesia/metabolismo
Hiperestesia/metabolismo
Neurônios/metabolismo
Canais de Cátion TRPV/metabolismo
Sensação Térmica/fisiologia
Gânglio Trigeminal/citologia
[Mh] Termos MeSH secundário: Animais
Queimaduras/fisiopatologia
Temperatura Baixa
Temperatura Alta
Hiperalgesia/fisiopatologia
Hiperestesia/fisiopatologia
Camundongos
Camundongos Knockout
Camundongos Transgênicos
Plasticidade Neuronal
Neurônios/fisiologia
Canal de Cátion TRPA1
Canais de Cátion TRPM/genética
Canais de Cátion TRPM/metabolismo
Canais de Cátion TRPV/genética
Canais de Receptores Transientes de Potencial/genética
Canais de Receptores Transientes de Potencial/metabolismo
Gânglio Trigeminal/metabolismo
Gânglio Trigeminal/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (TRPA1 Cation Channel); 0 (TRPM Cation Channels); 0 (TRPM8 protein, mouse); 0 (TRPV Cation Channels); 0 (TRPV1 protein, mouse); 0 (Transient Receptor Potential Channels); 0 (Trpa1 protein, mouse)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161115
[St] Status:MEDLINE


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[PMID]:27811266
[Au] Autor:Servick K
[Ti] Título:Primed for pain.
[So] Source:Science;354(6312):569-571, 2016 Nov 04.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Analgésicos Opioides/efeitos adversos
Dor Crônica/tratamento farmacológico
Dor Crônica/fisiopatologia
Hiperalgesia
Limiar da Dor/efeitos dos fármacos
[Mh] Termos MeSH secundário: Analgésicos Opioides/administração & dosagem
Encéfalo/fisiopatologia
Temperatura Baixa
Temperatura Alta
Seres Humanos
Hiperalgesia/induzido quimicamente
Hiperalgesia/epidemiologia
Hiperalgesia/fisiopatologia
Hiperestesia/induzido quimicamente
Hiperestesia/epidemiologia
Hiperestesia/fisiopatologia
Transtornos Relacionados ao Uso de Opioides/epidemiologia
Limiar da Dor/fisiologia
Receptores de N-Metil-D-Aspartato/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Opioid); 0 (Receptors, N-Methyl-D-Aspartate)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161105
[St] Status:MEDLINE


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[PMID]:27608525
[Au] Autor:Gandolfi S; Auquit-Auckbur I; Panunzi S; Mici E; Grolleau JL; Chaput B
[Ad] Endereço:Plastic and Reconstructive Surgery Unit, Faculty of Medicine, University Toulouse Rangueil, CHU Rangueil, 1, Avenue Jean-Poulhès, 31059 Toulouse, France.
[Ti] Título:Validation of the French version of the Burn Specific Health Scale-Brief (BSHS-B) questionnaire.
[So] Source:Burns;42(7):1573-1580, 2016 Nov.
[Is] ISSN:1879-1409
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The Burn Specific Health Scale-Brief questionnaire is a widely validated tool for estimating the health related quality of life and for assessing the best multidisciplinary management of burn patients. The aim of this study was to translate the BSHS-B into French and to investigate its reliability and validity. METHODS: According to the procedure proposed by the Scientific Advisory Committee of the Medical Outcomes Trust, the Burn Specific Health Scale-Brief (BSHS-B) was translated from the English version into French. In order to test the reliability of the French version of the BSHS-B, 53 burn patients French speakers completed the BSHS-B and SF-36 questionnaires from two to four years after burn. Ten of them have been re-tested at 6 months after the first evaluation. To evaluate clinical utility of the BSHS-F, internal consistency, construct validity (using SF-36) and stability in time were assessed using Cronbach's alpha statistic, Spearman rank test, and intra-class correlation coefficient respectively. RESULTS: The French version of the BSHS-B Cronbach's alpha coefficient was 0.93 and was >0.80 for all the sub-domains. French version of the BSHS-B and the SF-36 were positively correlated, all the associations were statistically significant (p<0.01). Intra-class correlation coefficients for test-retest ranged between 0.95 and 0.99 for the sub-domains. The intra-class correlation coefficient (ICC) for the total score was 0.98. CONCLUSION: The French version of the BSHS-B shows a robust rate of internal consistency, construct validity and stability in time, supporting its application in routine clinical practice as well as in international studies.
[Mh] Termos MeSH primário: Atividades Cotidianas
Afeto
Imagem Corporal/psicologia
Queimaduras/psicologia
Nível de Saúde
Relações Interpessoais
Qualidade de Vida
Sexualidade/psicologia
[Mh] Termos MeSH secundário: Adulto
Queimaduras/complicações
Queimaduras/fisiopatologia
Queimaduras/terapia
Feminino
Seres Humanos
Hiperestesia/etiologia
Hiperestesia/fisiopatologia
Hiperestesia/psicologia
Masculino
Meia-Idade
Psicometria
Inquéritos e Questionários
Traduções
Trabalho
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160910
[St] Status:MEDLINE


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[PMID]:27007066
[Au] Autor:Pedler A; Kamper SJ; Sterling M
[Ad] Endereço:aRECOVER Injury Research Centre, NHMRC Centre of Research Excellence in Recovery After Road Traffic Injury, Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia bThe George Institute for Global Health, University of Sydney, Sydney, Australia.
[Ti] Título:Addition of posttraumatic stress and sensory hypersensitivity more accurately estimates disability and pain than fear avoidance measures alone after whiplash injury.
[So] Source:Pain;157(8):1645-54, 2016 08.
[Is] ISSN:1872-6623
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The fear avoidance model (FAM) has been proposed to explain the development of chronic disability in a variety of conditions including whiplash-associated disorders (WADs). The FAM does not account for symptoms of posttraumatic stress and sensory hypersensitivity, which are associated with poor recovery from whiplash injury. The aim of this study was to explore a model for the maintenance of pain and related disability in people with WAD including symptoms of PTSD, sensory hypersensitivity, and FAM components. The relationship between individual components in the model and disability and how these relationships changed over the first 12 weeks after injury were investigated. We performed a longitudinal study of 103 (74 female) patients with WAD. Measures of pain intensity, cold and mechanical pain thresholds, symptoms of posttraumatic stress, pain catastrophising, kinesiophobia, and fear of cervical spine movement were collected within 6 weeks of injury and at 12 weeks after injury. Mixed-model analysis using Neck Disability Index (NDI) scores and average 24-hour pain intensity as the dependent variables revealed that overall model fit was greatest when measures of fear of movement, posttraumatic stress, and sensory hypersensitivity were included. The interactive effects of time with catastrophising and time with fear of activity of the cervical spine were also included in the best model for disability. These results provide preliminary support for the addition of neurobiological and stress system components to the FAM to explain poor outcome in patients with WAD.
[Mh] Termos MeSH primário: Aprendizagem da Esquiva/fisiologia
Sensibilização do Sistema Nervoso Central/fisiologia
Medo/psicologia
Hiperestesia/etiologia
Transtornos de Estresse Pós-Traumáticos/etiologia
Traumatismos em Chicotada/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Catastrofização/complicações
Catastrofização/psicologia
Temperatura Baixa
Avaliação da Deficiência
Feminino
Seres Humanos
Hiperestesia/psicologia
Estudos Longitudinais
Masculino
Meia-Idade
Limiar da Dor/fisiologia
Índice de Gravidade de Doença
Transtornos de Estresse Pós-Traumáticos/psicologia
Traumatismos em Chicotada/complicações
Traumatismos em Chicotada/psicologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160324
[St] Status:MEDLINE
[do] DOI:10.1097/j.pain.0000000000000564


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[PMID]:26882945
[Au] Autor:Keefer L; Kahrilas PJ
[Ad] Endereço:Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
[Ti] Título:Low-Dose Tricyclics for Esophageal Hypersensitivity: Is it all Placebo Effect?
[So] Source:Am J Gastroenterol;111(2):225-7, 2016 Feb.
[Is] ISSN:1572-0241
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Limsrivilai et al. report on a randomized control trial (RCT) testing the efficacy of imipramine for treating esophageal hypersensitivity and functional heartburn, the first RCT to test this therapy in this indication. Among 43 functional heartburn and esophageal hypersensitivity patients randomized to treatment with 25 mg qhs imipramine and 40 randomized to matched placebo, the response rates, judged by a 50% reduction in gastroesophageal reflux disease symptoms, were 37.2% and 37.5%, respectively, with no observed difference between patients with hypersensitivity and those with functional heartburn. On the positive side, imipramine treatment was associated with improvement in quality of life as assessed by total SF-36 score. Although negative at first glance, there are several important lessons from this study: (i) low-dose tricyclic is sufficient in these patients; (ii) proton pump inhibitors can (and should) be discontinued when they are ineffective; and (iii) distinguishing between functional heartburn and esophageal hypersensitivity is of unclear clinical relevance.
[Mh] Termos MeSH primário: Antidepressivos Tricíclicos/uso terapêutico
Refluxo Gastroesofágico/tratamento farmacológico
Azia/tratamento farmacológico
Hiperestesia/tratamento farmacológico
Imipramina/uso terapêutico
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:COMMENT; EDITORIAL
[Nm] Nome de substância:
0 (Antidepressive Agents, Tricyclic); OGG85SX4E4 (Imipramine)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160218
[St] Status:MEDLINE
[do] DOI:10.1038/ajg.2016.13


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[PMID]:26852761
[Au] Autor:Deiteren A; de Wit A; van der Linden L; De Man JG; Pelckmans PA; De Winter BY
[Ti] Título:Irritable bowel syndrome and visceral hypersensitivity : risk factors and pathophysiological mechanisms.
[So] Source:Acta Gastroenterol Belg;79(1):29-38, 2016 Mar.
[Is] ISSN:1784-3227
[Cp] País de publicação:Belgium
[La] Idioma:eng
[Ab] Resumo:Irritable bowel syndrome (IBS) is a common functional gastro-intestinal disorder, characterized by abdominal pain and altered intestinal motility. Visceral hypersensitivity is an important hallmark feature of IBS and is believed to underlie abdominal pain in patients with IBS. The two main risk factors associated with the development of IBS are gastrointestinal inflammation and psychological distress. On a peripheral level, visceral sensitivity seems to be modulated by several mechanisms. Immune cells in the mucosal wall, such as mast cells, and enterochromaffin cells may sensitize afferent nerves by release of their mediators. Furthermore, increased mucosal permeability, altered intestinal microflora and dietary habits may contribute to this feature. On a central level, an increased prevalence of psychiatric comorbidities is demonstrated in IBS patients, alongside alterations in the hormonal brain-gut axis, increased vigilance towards intestinal stimuli and functional and structural changes in the brain. The pathogenesis of IBS is complicated and multifactorial and the treatment remains clinically challenging. Dietary measures and symptomatic control are the cornerstones for IBS treatment and may be sufficient for patients experiencing mild symptoms, alongside education, reassurance and an effective therapeutic physician-patient relationship. New pharmacological therapies are aimed at interfering with mediator release and/or blockade of the relevant receptors within the gut wall, while modulation of the intestinal flora and diet may also be of therapeutic benefit. Tricyclic anti-depressants and serotonin reuptake inhibitors act both on a central and peripheral level by modulating pain signalling pathways.
[Mh] Termos MeSH primário: Dor Abdominal/imunologia
Encéfalo/fisiopatologia
Hiperalgesia/imunologia
Hiperestesia/imunologia
Intestinos/imunologia
Síndrome do Intestino Irritável/imunologia
Estresse Psicológico/fisiopatologia
[Mh] Termos MeSH secundário: Dor Abdominal/fisiopatologia
Dor Abdominal/psicologia
Seres Humanos
Hiperalgesia/fisiopatologia
Hiperalgesia/psicologia
Hiperestesia/fisiopatologia
Hiperestesia/psicologia
Intestinos/inervação
Intestinos/fisiopatologia
Síndrome do Intestino Irritável/fisiopatologia
Síndrome do Intestino Irritável/psicologia
Estresse Psicológico/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160923
[Lr] Data última revisão:
160923
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160209
[St] Status:MEDLINE


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[PMID]:26843440
[Au] Autor:Ghosh D; Pinto S; Danglot L; Vandewauw I; Segal A; Van Ranst N; Benoit M; Janssens A; Vennekens R; Vanden Berghe P; Galli T; Vriens J; Voets T
[Ad] Endereço:Laboratory of Ion Channel Research and TRP Channel Research Platform Leuven (TRPLe), Department of Cellular and Molecular Medicine, University of Leuven, Herestraat 49 box 802, B-3000 Leuven, Belgium.
[Ti] Título:VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8.
[So] Source:Nat Commun;7:10489, 2016 Feb 04.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The cation channel TRPM8 plays a central role in the somatosensory system, as a key sensor of innocuously cold temperatures and cooling agents. Although increased functional expression of TRPM8 has been implicated in various forms of pathological cold hypersensitivity, little is known about the cellular and molecular mechanisms that determine TRPM8 abundance at the plasma membrane. Here we demonstrate constitutive transport of TRPM8 towards the plasma membrane in atypical, non-acidic transport vesicles that contain lysosomal-associated membrane protein 1 (LAMP1), and provide evidence that vesicle-associated membrane protein 7 (VAMP7) mediates fusion of these vesicles with the plasma membrane. In line herewith, VAMP7-deficient mice exhibit reduced functional expression of TRPM8 in sensory neurons and concomitant deficits in cold avoidance and icilin-induced cold hypersensitivity. Our results uncover a cellular pathway that controls functional plasma membrane incorporation of a temperature-sensitive TRP channel, and thus regulates thermosensitivity in vivo.
[Mh] Termos MeSH primário: Membrana Celular/metabolismo
Temperatura Baixa
Hiperestesia/genética
Proteínas R-SNARE/genética
Células Receptoras Sensoriais/metabolismo
Canais de Cátion TRPM/metabolismo
Vesículas Transportadoras/metabolismo
[Mh] Termos MeSH secundário: Animais
Cálcio/metabolismo
Feminino
Gânglios Espinais/metabolismo
Células HEK293
Seres Humanos
Hiperestesia/induzido quimicamente
Hiperestesia/metabolismo
Glicoproteínas de Membrana Associadas ao Lisossomo/metabolismo
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Microscopia de Fluorescência
Técnicas de Patch-Clamp
Pirimidinonas/toxicidade
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Gânglio Trigeminal/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Lamp1 protein, mouse); 0 (Lysosome-Associated Membrane Glycoproteins); 0 (Pyrimidinones); 0 (R-SNARE Proteins); 0 (Sybl1 protein, mouse); 0 (TRPM Cation Channels); 0 (TRPM8 protein, mouse); CS70PZQ4QJ (icilin); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160205
[St] Status:MEDLINE
[do] DOI:10.1038/ncomms10489


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[PMID]:26788281
[Au] Autor:Wicker B; Monfardini E; Royet JP
[Ad] Endereço:Institut de Neurosciences de la Timone. CNRS & Université Aix-Marseille, Campus Santé Timone 27, Boulevard Jean Moulin, 13385 Marseille cedex 05, France.
[Ti] Título:Olfactory processing in adults with autism spectrum disorders.
[So] Source:Mol Autism;7:4, 2016.
[Is] ISSN:2040-2392
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: As evidenced in the DSM-V, autism spectrum disorders (ASD) are often characterized by atypical sensory behavior (hyper- or hypo-reactivity), but very few studies have evaluated olfactory abilities in individuals with ASD. METHODS: Fifteen adults with ASD and 15 typically developing participants underwent olfactory tests focused on superficial (suprathreshold detection task), perceptual (intensity and pleasantness judgment tasks), and semantic (identification task) odor processing. RESULTS: In terms of suprathreshold detection performance, decreased discrimination scores and increased bias scores were observed in the ASD group. Furthermore, the participants with ASD exhibited increased intensity judgment scores and impaired scores for pleasantness judgments of unpleasant odorants. Decreased identification performance was also observed in the participants with ASD compared with the typically developing participants. This decrease was partly attributed to a higher number of near misses (a category close to veridical labels) among the participants with ASD than was observed among the typically developing participants. CONCLUSIONS: The changes in discrimination and bias scores were the result of a high number of false alarms among the participants with ASD, which suggests the adoption of a liberal attitude in their responses. Atypical intensity and pleasantness ratings were associated with hyperresponsiveness and flattened emotional reactions, respectively, which are typical of participants with ASD. The high number of near misses as non-veridical labels suggested that categorical processing is functional in individuals with ASD and could be explained by attention-deficit/hyperactivity disorder. These findings are discussed in terms of dysfunction of the olfactory system.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista/fisiopatologia
Odorantes
Condutos Olfatórios/fisiopatologia
Percepção Olfatória
[Mh] Termos MeSH secundário: Adulto
Transtorno do Espectro Autista/psicologia
Limiar Diferencial/fisiologia
Emoções/fisiologia
Feminino
Seres Humanos
Hiperestesia/etiologia
Hiperestesia/fisiopatologia
Hiperestesia/psicologia
Hipestesia/etiologia
Hipestesia/fisiopatologia
Hipestesia/psicologia
Masculino
Percepção Olfatória/fisiologia
Prazer
Recognição (Psicologia)/fisiologia
Limiar Sensorial
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1604
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160121
[St] Status:MEDLINE
[do] DOI:10.1186/s13229-016-0070-3



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