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[PMID]: 25815856 [Au] Autor: de Haan GA; Heutink J; Melis-Dankers BJ; Brouwer WH; Tucha O [Ad] Endereço: Department of Clinical and Developmental Neuropsychology (GAdH, JH, WHB, OT), University of Groningen, Groningen, the Netherlands; Department of Rehabilitation & Advice (GAdH, JH, BJMM-D), Royal Dutch Visio, Centre of Expertise for Blind and Partially Sighted People, Haren, the Netherlands; and Department of Neurology (WHB), University Medical Center Groningen, Groningen, the Netherlands. [Ti] Título: Difficulties in Daily Life Reported by Patients With Homonymous Visual Field Defects. [So] Source: J Neuroophthalmol;35(3):259-64, 2015 Sep. [Is] ISSN: 1536-5166 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Homonymous visual field defects (HVFD) are common after postchiasmatic acquired brain injury and may have a significant impact on independent living and participation in society. Vision-related difficulties experienced in daily life are usually assessed using questionnaires. The current study 1) links the content of 3 of these questionnaires to the International Classification of Functioning, Disability and Health (ICF) and 2) provides analyses of vision-related difficulties reported by patients with HVFD and minimal comorbidities. METHODS: Fifty-four patients with homonymous hemianopia or quadrantanopia were asked about difficulties experienced in daily life because of their HVFD. This was performed during a structured interview including 3 standardized questionnaires: National Eye Institute Visual Functioning Questionnaire, Independent Mobility Questionnaire, and Cerebral Visual Disorders Questionnaire. The reported difficulties were linked to the ICF according to the ICF linking rules. Main outcome measures were presence or absence of experienced difficulties. RESULTS: The ICF linking procedure resulted in a classification table that can be used in future studies of vision-related difficulties. Besides well-known difficulties related to reading, orientation, and mobility, a high proportion of patients with HVFD reported problems that previously have not been documented in the literature, such as impaired light sensitivity, color vision, and perception of depth. CONCLUSIONS: A systematic inventory of difficulties experienced in daily life by patients with HVFD was performed using the ICF. These findings have implications for future study, assessment and rehabilitation of patients with HVFD. [Mh] Termos MeSH primário: Atividades Cotidianas/psicologia Avaliação da Deficiência Hemianopsia/fisiopatologia Hemianopsia/psicologia Campos Visuais/fisiologia [Mh] Termos MeSH secundário: Visão de Cores Percepção de Profundidade Feminino Seres Humanos Masculino Inquéritos e Questionários Testes de Campo Visual [Pt] Tipo de publicação: JOURNAL ARTICLE; MULTICENTER STUDY [Em] Mês de entrada: 1606 [Cu] Atualização por classe: 180116 [Lr] Data última revisão: 180116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150328 [St] Status: MEDLINE [do] DOI: 10.1097/WNO.0000000000000244

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[PMID]: 29019903 [Au] Autor: Chung J; Jin KH; Kang J; Kim TG [Ad] Endereço: aDepartment of Ophthalmology, Kyung Hee University Hospital at Gangdong bDepartment of Ophthalmology, Kyung Hee University Medical Center, Kyung Hee University, Seoul, Korea. [Ti] Título: An atypical presentation of functional visual loss: A case report. [So] Source: Medicine (Baltimore);96(41):e8292, 2017 Oct. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE: Functional visual loss (FVL) can manifest as various symptoms. Decreased distant visual acuity is the most common symptom and visual field defect is the second most common symptom. Hemianopsia is rarely reported. In an atypical situation of FVL, it is important to prove that no organic pathology exists, through detailed history taking and appropriate examinations. PATIENT CONCERNS: This review presents the case of a 48-year-old male patient presented with decreased bilateral visual acuity and visual field defect after a traffic accident 3 weeks ago. Visual field test showed atypical features of FVL in which visual field change from binasal hemianopsia to left homonymous hemianopsia. DIAGNOSIS: The best corrected visual acuities (BCVA) were 20/63 in both eyes and binasal hemianopsia was observed on a Humphrey visual field test. Brain computed tomography (CT) scan and magnetic resonance imaging (MRI) showed no abnormalities in the brain and optic chiasm. Two weeks after presentation, however, the patient's visual field defect changed from binasal hemianopsia to left homonymous hemianopsia. We diagnosed it as FVL due to conversion disorder. INTERVENTION AND OUTCOMES: We decided to cooperate with a psychiatrist for cognitive behavioral therapy and the patient is under observation. LESSONS: Binasal hemianopsia and homonymous hemianopsia are rare; however, it may occur simultaneously in 1 patient with FVL. The possibility of FVL should be considered when there is atypical visual field defect and no organic abnormalities are observed. Repeated Humphrey field test and VEP may be helpful in diagnosis of FVL. [Mh] Termos MeSH primário: Acidentes de Trânsito/psicologia Hemianopsia Estresse Psicológico Acuidade Visual [Mh] Termos MeSH secundário: Encéfalo/diagnóstico por imagem Terapia Cognitiva/métodos Diagnóstico Diferencial Hemianopsia/diagnóstico Hemianopsia/etiologia Hemianopsia/psicologia Hemianopsia/terapia Seres Humanos Imagem por Ressonância Magnética/métodos Masculino Meia-Idade Estresse Psicológico/complicações Estresse Psicológico/fisiopatologia Tomografia Computadorizada por Raios X/métodos Resultado do Tratamento Testes de Campo Visual/métodos [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171122 [Lr] Data última revisão: 171122 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 171012 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000008292

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[PMID]: 28863215 [Au] Autor: Sousa RM; Oyamada MK; Cunha LP; Monteiro MLR [Ad] Endereço: Division of Ophthalmology and Laboratory of Investigation in Ophthalmology (LIM 33), University of São Paulo Medical School, São Paulo, Brazil. [Ti] Título: Multifocal Visual Evoked Potential in Eyes With Temporal Hemianopia From Chiasmal Compression: Correlation With Standard Automated Perimetry and OCT Findings. [So] Source: Invest Ophthalmol Vis Sci;58(11):4436-4449, 2017 Sep 01. [Is] ISSN: 1552-5783 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Purpose: To verify whether multifocal visual evoked potential (mfVEP) can differentiate eyes with temporal hemianopia due to chiasmal compression from healthy controls. To assess the relationship between mfVEP, standard automated perimetry (SAP), and Fourier domain-optical coherence tomography (FD-OCT) macular and peripapillary retinal nerve fiber layer (RNFL) thickness measurements. Methods: Twenty-seven eyes with permanent temporal visual field (VF) defects from chiasmal compression on SAP and 43 eyes of healthy controls were submitted to mfVEP and FD-OCT scanning. Multifocal visual evoked potential was elicited using a stimulus pattern of 60 sectors and the responses were averaged for the four quadrants and two hemifields. Optical coherence tomography macular measurements were averaged in quadrants and halves, while peripapillary RNFL thickness was averaged in four sectors around the disc. Visual field loss was estimated in four quadrants and each half of the 24-2 strategy test points. Multifocal visual evoked potential measurements in the two groups were compared using generalized estimated equations, and the correlations between mfVEP, VF, and OCT findings were quantified. Results: Multifocal visual evoked potential-measured temporal P1 and N2 amplitudes were significantly smaller in patients than in controls. No significant difference in amplitude was observed for nasal parameters. A significant correlation was found between mfVEP amplitudes and temporal VF loss, and between mfVEP amplitudes and the corresponding OCT-measured macular and RNFL thickness parameters. Conclusions: Multifocal visual evoked potential amplitude parameters were able to differentiate eyes with temporal hemianopia from controls and were significantly correlated with VF and OCT findings, suggesting mfVEP is a useful tool for the detection of visual abnormalities in patients with chiasmal compression. [Mh] Termos MeSH primário: Potenciais Evocados Visuais/fisiologia Hemianopsia/diagnóstico Síndromes de Compressão Nervosa/diagnóstico Quiasma Óptico/patologia Doenças do Nervo Óptico/diagnóstico Tomografia de Coerência Óptica Testes de Campo Visual [Mh] Termos MeSH secundário: Adulto Feminino Análise de Fourier Voluntários Saudáveis Hemianopsia/fisiopatologia Seres Humanos Masculino Meia-Idade Imagem Multimodal Síndromes de Compressão Nervosa/fisiopatologia Fibras Nervosas/patologia Quiasma Óptico/fisiopatologia Doenças do Nervo Óptico/fisiopatologia Células Ganglionares da Retina/patologia Estatística como Assunto Transtornos da Visão/diagnóstico Transtornos da Visão/fisiopatologia Campos Visuais/fisiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170908 [Lr] Data última revisão: 170908 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170902 [St] Status: MEDLINE [do] DOI: 10.1167/iovs.17-21529

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[PMID]: 28727615 [Au] Autor: Peli E; Jung JH [Ad] Endereço: Schepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts. [Ti] Título: Multiplexing Prisms for Field Expansion. [So] Source: Optom Vis Sci;94(8):817-829, 2017 Aug. [Is] ISSN: 1538-9235 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: PURPOSE: Prisms used for field expansion are limited by the optical scotoma at a prism apex (apical scotoma). For a patient with two functioning eyes, fitting prisms unilaterally allows the other eye to compensate for the apical scotoma. A monocular patient's field loss cannot be expanded with a conventional or Fresnel prism because of the apical scotoma. A newly invented optical device, the multiplexing prism (MxP), was developed to overcome the apical scotoma limitation in monocular field expansion. METHODS: A Fresnel-prism-like device with alternating prism and flat elements superimposes shifted and see-through views, thus creating the (monocular) visual confusion required for field expansion and eliminating the apical scotoma. Several implementations are demonstrated and preliminarily evaluated for different monocular conditions with visual field loss. The field expansion of the MxP is compared with the effect of conventional prisms using calculated and measured perimetry. RESULTS: Field expansion without apical scotomas is shown to be effective for monocular patients with hemianopia or constricted peripheral field. The MxPs are shown to increase the nasal field for a patient with only one eye and for patients with bitemporal hemianopia. The MxPs placed at the far temporal field are shown to expand the normal visual field. The ability to control the contrast ratio between the two images is verified. CONCLUSIONS: A novel optical device is demonstrated to have the potential for field expansion technology in a variety of conditions. The devices may be inexpensive and can be constructed in a cosmetically acceptable format. [Mh] Termos MeSH primário: Hemianopsia/reabilitação Dispositivos Ópticos Visão Binocular/fisiologia Campos Visuais/fisiologia [Mh] Termos MeSH secundário: Adulto Feminino Hemianopsia/fisiopatologia Seres Humanos Masculino Meia-Idade Visão Monocular/fisiologia Testes de Campo Visual [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170913 [Lr] Data última revisão: 170913 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170721 [St] Status: MEDLINE [do] DOI: 10.1097/OPX.0000000000001102

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[PMID]: 28723787 [Au] Autor: Shin HY; Kim SH; Lee MY; Kim SY; Lee YC [Ad] Endereço: Department of Ophthalmology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. [Ti] Título: Late emergence of macular sparing in a stroke patient: Clinical Case Report. [So] Source: Medicine (Baltimore);96(29):e7567, 2017 Jul. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE: Occlusive cerebrovascular disease is the most common cause of homonymous hemianopia (HH) with macular sparing. PATIENT CONCERNS: A 61-year-old man came to our ophthalmology clinic complaining of right-side hemianopia. Ophthalmic examination, visual field (VF) examination, and brain magnetic resonance imaging (MRI) were performed. DIAGNOSES: He had right HH without macular sparing on the initial VF test. And brain MRI 6 days after the visual symptoms began revealed a left occipital infarction. INTERVENTIONS AND OUTCOMES: Thirty-seven days after the onset, his follow-up 24-2 VF examination showed HH with bilateral macular sparing, which was not apparent in the initial VF examination. About 4 months after the stroke, his central 10-2 VF examination also showed HH with bilateral macular sparing. LESSONS: We report a case of HH with a dramatic improvement in central vision several days after an occipital infarction. To our knowledge, this is the first case to show macular sparing developing after several days. [Mh] Termos MeSH primário: Infarto Encefálico/complicações Hemianopsia/etiologia Lobo Occipital [Mh] Termos MeSH secundário: Infarto Encefálico/diagnóstico Infarto Encefálico/fisiopatologia Infarto Encefálico/terapia Diagnóstico Diferencial Progressão da Doença Hemianopsia/diagnóstico Hemianopsia/fisiopatologia Seres Humanos Masculino Meia-Idade Lobo Occipital/diagnóstico por imagem [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170808 [Lr] Data última revisão: 170808 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170721 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000007567

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[PMID]: 28526645 [Au] Autor: Woodall MN; Alleyne CH [Ad] Endereço: The Medical College of Georgia at Augusta University, Augusta, Georgia, USA. Electronic address: mneilwoodall@gmail.com. [Ti] Título: Carotid-Falciform Optic Neuropathy: Microsurgical Treatment. [So] Source: World Neurosurg;104:372-375, 2017 Aug. [Is] ISSN: 1878-8769 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Several recent reports have implicated vascular ectasia and vessel contact in dysfunction of the visual apparatus. A subset of patients with prechiasmatic visual deterioration have an ectatic internal carotid artery (ICA) that displaces and flattens the optic nerve (ON) rostrally as the ON exits the skull base. We describe a proposed pathophysiologic mechanism and a straightforward surgical technique for dealing with this problem. METHODS: Via an ipsilateral pterional craniotomy, the bony roof of the optic canal is removed. The falciform ligament is opened in parallel to the ON. Adhesions between the ICA and ON are then dissected, and a Teflon pledget is placed between the ICA and ON to complete the decompression. RESULTS: Patients both in the literature and in this series experienced an improvement in their vision postoperatively. CONCLUSIONS: We propose that 3 mechanisms contribute to this caroticofalciform optic neuropathy: 1) mass effect from ICA ectasia, 2) ON irritation from vessel pulsatility, and 3) indirect compression by the falciform ligament from above. This disease process can be treated safely using standard microsurgical techniques with excellent outcomes. [Mh] Termos MeSH primário: Doenças das Artérias Carótidas/cirurgia Artéria Carótida Interna/cirurgia Craniotomia/métodos Descompressão Cirúrgica/métodos Ligamentos/cirurgia Microcirurgia/métodos Síndromes de Compressão Nervosa/cirurgia Doenças do Nervo Óptico/cirurgia Base do Crânio/cirurgia [Mh] Termos MeSH secundário: Adulto Idoso Dilatação Patológica/cirurgia Feminino Hemianopsia/etiologia Hemianopsia/cirurgia Seres Humanos Comunicação Interdisciplinar Colaboração Intersetorial Imagem por Ressonância Magnética Masculino Baixa Visão/etiologia Baixa Visão/cirurgia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170927 [Lr] Data última revisão: 170927 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170521 [St] Status: MEDLINE

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[PMID]: 28502693 [Au] Autor: Morris SA; Rollo M; Rollo P; Johnson J; Grant GA; Friedman E; Kalamangalam G; Tandon N [Ad] Endereço: Vivian L. Smith Department of Neurosurgery, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas, USA. [Ti] Título: Prolonged Blood-Brain Barrier Disruption Following Laser Interstitial Ablation in Epilepsy: A Case Series with a Case Report of Postablation Optic Neuritis. [So] Source: World Neurosurg;104:467-475, 2017 Aug. [Is] ISSN: 1878-8769 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVE: Laser interstitial thermal therapy has become increasingly popular for targeting epileptic foci in a minimally invasive fashion. Despite its use in >1000 patients, the long-term effects of photothermal injury on brain physiology remain poorly understood. METHODS: We prospectively followed clinical and radiographic courses of 13 patients undergoing laser ablation for focal epilepsy by the senior author (N.T.). Only patients with nonenhancing lesions and patients who had a delayed postoperative magnetic resonance imaging (MRI) scan with gadolinium administration approximately 6 months after ablation were considered. Volumetric estimates of the amount of enhancement immediately after ablation and on the delayed MRI scan were made. RESULTS: Median interval between surgery and delayed postoperative MRI scan was 6 months (range, 5-8 months). In 12 of 13 cases, persistent enhancement was seen, consistent with prolonged blood-brain barrier dysfunction. Enhancement, when present, was 9%-67% (mean 30%). There was no correlation between the time from surgery and the relative percentage of postoperative enhancement on MRI. The blood-brain barrier remained compromised to gadolinium contrast for up to 8 months after thermal therapy. There were no adverse events from surgical intervention; however, 1 patient developed delayed optic neuritis. CONCLUSIONS: Prolonged incompetence of the blood-brain barrier produced by thermal ablation may provide a path for delivery of macromolecules into perilesional tissue, which could be exploited for therapeutic benefit, but rarely it may result in autoimmune central nervous system inflammatory conditions. [Mh] Termos MeSH primário: Barreira Hematoencefálica/fisiologia Epilepsia Resistente a Medicamentos/fisiopatologia Epilepsia Resistente a Medicamentos/cirurgia Epilepsias Parciais/fisiopatologia Epilepsias Parciais/cirurgia Epilepsia Parcial Complexa/fisiopatologia Epilepsia Parcial Complexa/cirurgia Epilepsia Motora Parcial/fisiopatologia Epilepsia Motora Parcial/cirurgia Epilepsia do Lobo Temporal/fisiopatologia Epilepsia do Lobo Temporal/cirurgia Hemianopsia/diagnóstico Hemianopsia/fisiopatologia Terapia a Laser/métodos Neurite Óptica/diagnóstico Neurite Óptica/fisiopatologia Complicações Pós-Operatórias/diagnóstico Complicações Pós-Operatórias/fisiopatologia Técnicas Estereotáxicas Cirurgia Assistida por Computador/métodos [Mh] Termos MeSH secundário: Adolescente Adulto Estudos de Coortes Angiografia por Tomografia Computadorizada Meios de Contraste Feminino Gadolínio Seres Humanos Interpretação de Imagem Assistida por Computador Terapia a Laser/instrumentação Imagem por Ressonância Magnética Masculino Meia-Idade Estudos Prospectivos Cirurgia Assistida por Computador/instrumentação Adulto Jovem [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Contrast Media); AU0V1LM3JT (Gadolinium) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170928 [Lr] Data última revisão: 170928 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170516 [St] Status: MEDLINE

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[PMID]: 28438131 [Au] Autor: Nesaratnam N; Thomas PBM; Kirollos R; Vingrys AJ; Kong GYX; Martin KR [Ad] Endereço: Department of Ophthalmology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, CB2 0QQ, UK. nisha.n@doctors.org.uk. [Ti] Título: Tablets at the bedside - iPad-based visual field test used in the diagnosis of Intrasellar Haemangiopericytoma: a case report. [So] Source: BMC Ophthalmol;17(1):53, 2017 Apr 24. [Is] ISSN: 1471-2415 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: In the assessment of a pituitary mass, objective visual field testing represents a valuable means of evaluating mass effect, and thus in deciding whether surgical management is warranted. CASE PRESENTATION: In this vignette, we describe a 73 year-old lady who presented with a three-week history of frontal headache, and 'blurriness' in the left side of her vision, due to a WHO grade III anaplastic haemangiopericytoma compressing the optic chiasm. We report how timely investigations, including an iPad-based visual field test (Melbourne Rapid Field, (MRF)) conducted at the bedside aided swift and appropriate management of the patient. CONCLUSIONS: We envisage such a test having a role in assessing bed-bound patients in hospital where access to formal visual field testing is difficult, or indeed in rapid testing of visual fields at the bedside to screen for post-operative complications, such as haematoma. [Mh] Termos MeSH primário: Computadores de Mão Hemangiopericitoma/diagnóstico Hemianopsia/diagnóstico Quiasma Óptico/patologia Neoplasias Hipofisárias/diagnóstico Testes Imediatos Testes de Campo Visual/instrumentação [Mh] Termos MeSH secundário: Idoso Diagnóstico Diferencial Feminino Hemangiopericitoma/complicações Hemianopsia/etiologia Seres Humanos Imagem por Ressonância Magnética Neoplasias Hipofisárias/complicações Acuidade Visual Campos Visuais [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170919 [Lr] Data última revisão: 170919 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170426 [St] Status: MEDLINE [do] DOI: 10.1186/s12886-017-0445-z

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[PMID]: 28350571 [Au] Autor: Holmes BB; Green WC; Kung NH; Goebel JA; Van Stavern GP [Ad] Endereço: Medical Scientist Training Program (BBH), Washington University School of Medicine, St. Louis, Missouri Departments of Ophthalmology and Visual Sciences (WCG, NHK, GPVS) and Otolaryngology-Head & Neck Surgery (JAG), Washington University, St. Louis, Missouri. [Ti] Título: Vertebrobasilar Dolichoectasia Causing An Optic Tract Syndrome. [So] Source: J Neuroophthalmol;37(2):179-181, 2017 Jun. [Is] ISSN: 1536-5166 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Vertebrobasilar dolichoectasia (VBD) is characterized by significant dilation, elongation, and tortuosity of the vertebrobasilar system. We present a unique case of VBD, confirmed by neuroimaging studies, showing vascular compression of the right optic tract and lower cranial nerves leading to an incongruous left homonymous inferior quadrantanopia and glossopharyngeal neuralgia. [Mh] Termos MeSH primário: Doenças do Nervo Glossofaríngeo/etiologia Hemianopsia/etiologia Trato Óptico/diagnóstico por imagem Insuficiência Vertebrobasilar/complicações [Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais Diagnóstico Diferencial Doenças do Nervo Glossofaríngeo/diagnóstico Hemianopsia/diagnóstico Seres Humanos Angiografia por Ressonância Magnética Masculino Oftalmoscopia Síndrome Insuficiência Vertebrobasilar/diagnóstico [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170913 [Lr] Data última revisão: 170913 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170329 [St] Status: MEDLINE [do] DOI: 10.1097/WNO.0000000000000495

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[PMID]: 28237414 [Au] Autor: Handley SE; Vargha-Khadem F; Bowman RJ; Liasis A [Ad] Endereço: Clinical and Academic Department of Ophthalmology, Great Ormond Street Hospital for Children, London, United Kingdom; Institute of Child Health, University College London, London, United Kingdom. [Ti] Título: Visual Function 20 Years After Childhood Hemispherectomy for Intractable Epilepsy. [So] Source: Am J Ophthalmol;177:81-89, 2017 May. [Is] ISSN: 1879-1891 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: PURPOSE: To investigate visual function in adults post hemispherectomy in childhood. DESIGN: Noncomparative case series. METHODS: All participants underwent visual acuity, binocular function, visual field, optical coherence tomography (OCT) of the retinal nerve fiber layer (RNFL), and monocular pattern reversal visually evoked potentials (prVEP). PARTICIPANTS: Six adults who had a hemispherectomy in childhood (median 21.5 years postoperative). MAIN OUTCOME MEASURES: Comparison was made of visual acuity, visual field height, global RNFL thickness, and prVEP amplitude evoked by full- and half-field stimulation. Comparison of the eye ipsilateral to the side of surgery to the contralateral eye was achieved employing paired t tests to the visual function measures. RESULTS: All participants had homonymous hemianopia. The residual seeing visual field was constricted in all cases when compared with normative data despite crossing the midline into the blind hemifield in 11 of 12 eyes. This observation was supported by prVEP to stimuli presented in the blind half field. The height of the visual field was smaller in the eye contralateral to the side of surgery compared with the ipsilateral side (P = .047). Visual acuity and RNFL thickness also showed greater diminution in the contralateral eye (P = .040 and P = .0004). Divergent strabismus was found in 4 participants with greater field loss. CONCLUSIONS: Adults post hemispherectomy in childhood may have better visual function in the eye ipsilateral to the side of the hemispherectomy compared with the contralateral eye. Possible mechanisms of the interocular difference are discussed. Though visual fields and prVEP responses demonstrate evidence of reorganization into the blind half field, they also reveal significant unexpected constriction of the functional field. [Mh] Termos MeSH primário: Epilepsia Resistente a Medicamentos/cirurgia Previsões Hemianopsia/fisiopatologia Hemisferectomia/métodos Células Ganglionares da Retina/patologia Acuidade Visual/fisiologia Campos Visuais/fisiologia [Mh] Termos MeSH secundário: Adolescente Adulto Criança Epilepsia Resistente a Medicamentos/complicações Epilepsia Resistente a Medicamentos/fisiopatologia Potenciais Evocados Visuais/fisiologia Feminino Hemianopsia/diagnóstico Hemianopsia/etiologia Seres Humanos Masculino Período Pós-Operatório Reprodutibilidade dos Testes Tomografia de Coerência Óptica Visão Binocular/fisiologia Testes de Campo Visual Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170719 [Lr] Data última revisão: 170719 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170227 [St] Status: MEDLINE

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2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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