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[PMID]:29068979
[Au] Autor:Den Beste KA; Okeke C
[Ad] Endereço:aDepartment of Ophthalmology, Eastern Virginia Medical School bVirginia Eye Consultants, Norfolk, VA.
[Ti] Título:Trabeculotomy ab interno with Trabectome as surgical management for systemic fluoroquinolone-induced pigmentary glaucoma: A case report.
[So] Source:Medicine (Baltimore);96(43):e7936, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Bilateral acute iris transillumination (BAIT) is a poorly-understood ocular syndrome in which patients present with acute iridocyclitis and pigmentary dispersion with or without ocular hypertension. The etiology of the disease remains unknown, though recent reports suggest an antecedent upper respiratory tract infection or systemic antibiotic administration may trigger the clinical syndrome. PATIENT CONCERNS: A 55-year-old female was referred for a second opinion regarding her bilateral ocular pain, photophobia, and ocular hypertension. Her medical history was notable for a diagnosis of pneumonia managed with oral moxifloxacin several weeks prior to her initial presentation. DIAGNOSES: Visual acuity was 20/40 with an intraocular pressure (IOP) of 30 mmHg in the affected eye despite maximal tolerated medical therapy. The patient had severe bilateral iris transillumination defects with posterior synechiae formation and 3+ pigment with rare cell in the anterior chamber. This constellation of findings was consistent with a diagnosis of BAIT. INTERVENTIONS: A peripheral iridotomy was placed, which mildly relieved the iris bowing, but did not affect the IOP or inflammatory reaction. The patient then underwent cataract extraction with posterior synechiolysis and ab interno trabeculotomy of the left eye with the Trabectome. OUTCOMES: The patient's IOP on the first post-operative day was 13 mmHg, and anterior chamber inflammation was noted to be significantly reduced at post-operative week 2. The patient was recently seen at a 1-year post-operative visit and her IOP remains in the low teens on a low-dose combination topical agent. LESSONS: Ophthalmologists should remain aware of the association between systemic fluoroquinolones and acute pigmentary dispersion that can progress to glaucoma. The Trabectome remains a viable option for management of pigmentary and uveitic glaucoma resistant to medical treatment.
[Mh] Termos MeSH primário: Antibacterianos/efeitos adversos
Fluoroquinolonas/efeitos adversos
Glaucoma de Ângulo Aberto/induzido quimicamente
Glaucoma de Ângulo Aberto/cirurgia
Trabeculectomia/métodos
[Mh] Termos MeSH secundário: Extração de Catarata
Dor Ocular/induzido quimicamente
Feminino
Seres Humanos
Meia-Idade
Hipertensão Ocular/induzido quimicamente
Fotofobia/induzido quimicamente
Pneumonia Bacteriana/tratamento farmacológico
Trabeculectomia/instrumentação
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Fluoroquinolones); U188XYD42P (moxifloxacin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171123
[Lr] Data última revisão:
171123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007936


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[PMID]:28734636
[Au] Autor:Arveiler B; Lasseaux E; Morice-Picard F
[Ad] Endereço:CHU de Bordeaux, service de génétique médicale, 33076 Bordeaux, France; Laboratoire maladies rares, génétique et métabolisme, Inserm U1211, 33076 Bordeaux, France. Electronic address: benoit.arveiler@chu-bordeaux.fr.
[Ti] Título:[Clinical and genetic aspects of albinism].
[Ti] Título:Clinique et génétique de l'albinisme..
[So] Source:Presse Med;46(7-8 Pt 1):648-654, 2017 Jul - Aug.
[Is] ISSN:2213-0276
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:Albinism is a genetic disease affecting 1/17,000 person worldwide. It constitutes the second cause of congenital loss of visual acuity after optic atrophy. Albinism is heterogeneous both at the clinical and genetic levels. It is characterized by ocular development anomalies and by a variable degree of hypopigmentation. Clinically, three forms of the disease are described: oculocutaneous, ocular and syndromic (Hermansky-Pudlak syndrome, Chediak-Higashi syndrome). Nineteen genes involved in the different types of albinism have been described so far. The broad phenotypic variability between the different forms but also within a particular form renders the establishment of phenotype-genotype correlations impossible. A genetic test exploring all 19 genes is necessary to establish the diagnosis and to distinguish between syndromic and non-syndromic forms. We present the creation of an albinism-dedicated Day Hospital at the University Hospital of Bordeaux.
[Mh] Termos MeSH primário: Albinismo/genética
[Mh] Termos MeSH secundário: Síndrome de Chediak-Higashi/diagnóstico
Síndrome de Chediak-Higashi/genética
Testes Genéticos
Seres Humanos
Mutação
Fotofobia/etiologia
Transtornos da Visão/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170724
[St] Status:MEDLINE


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[PMID]:28715587
[Au] Autor:Aboshiha J; Kumaran N; Kalitzeos A; Hogg C; Rubin G; Michaelides M
[Ad] Endereço:UCL Institute of Ophthalmology, University College London, London, United Kingdom 2Moorfields Eye Hospital, London, United Kingdom.
[Ti] Título:A Quantitative and Qualitative Exploration of Photoaversion in Achromatopsia.
[So] Source:Invest Ophthalmol Vis Sci;58(9):3537-3546, 2017 Jul 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: Photoaversion (PA) is a disabling and ubiquitous feature of achromatopsia (ACHM). We aimed to help define the characteristics of this important symptom, and present the first published assessment of its impact on patients' lives, as well as quantitative and qualitative PA assessments. Methods: Molecularly confirmed ACHM subjects were assessed for PA using four tasks: structured survey of patient experience, novel quantitative subjective measurement of PA, visual acuities in differing ambient lighting, and objective palpebral aperture-related PA testing. Results: Photoaversion in ACHM was found to be the most significant symptom for a substantial proportion (38%) of patients. A novel subjective PA measurement technique was developed and demonstrated fidelity with more invasive paradigms without exposing often very photosensitive patients to brighter light intensities used elsewhere. An objective PA measurement was also refined for use in trials, indicating that higher light intensities than previously published are likely to be needed. Monocular testing, as required for trials, was also validated for the first time. Conclusions: This study offers new insights into PA in ACHM. It provides the first structured evidence of the great significance of this symptom to patients, suggesting that PA should be considered as an additional outcome measure in therapeutic trials. It also offers new insights into the characteristics of PA in ACHM, and describes both subjective and objective measures of PA that could be employed in clinical trials.
[Mh] Termos MeSH primário: Defeitos da Visão Cromática/fisiopatologia
Fotofobia/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Defeitos da Visão Cromática/diagnóstico
Eletrorretinografia
Feminino
Seres Humanos
Luz
Masculino
Fotofobia/diagnóstico
Retina/fisiopatologia
Inquéritos e Questionários
Tomografia de Coerência Óptica/métodos
Acuidade Visual/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170718
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-21935


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[PMID]:28390644
[Au] Autor:Mourad MR; Siwoski OM; Brownback KR
[Ad] Endereço:Division of Pulmonary and Critical Care Medicine, University of Kansas Medical Center, Kansas City, KS.
[Ti] Título:A 19-Year-Old College Student With Headache, Photophobia, and Flulike Illness.
[So] Source:Chest;151(4):e95-e98, 2017 Apr.
[Is] ISSN:1931-3543
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CASE PRESENTATION: A 19-year-old previously healthy man presented, minimally responsive, in respiratory distress to an ED after a 2-week history of headache, photophobia, and neck stiffness. Associated symptoms included low-grade fevers, malaise, and dark urine. He had no recent travel, ill contacts, consumption of undercooked meat, new sexual contacts, or illicit drug use. The patient resided in a campus dormitory and did not consume alcohol or tobacco.
[Mh] Termos MeSH primário: Enterite/microbiologia
Infecções por Fusobacterium/microbiologia
Fusobacterium necrophorum/isolamento & purificação
Linfo-Histiocitose Hemofagocítica/microbiologia
[Mh] Termos MeSH secundário: Dexametasona/uso terapêutico
Diagnóstico Diferencial
Enterite/tratamento farmacológico
Infecções por Fusobacterium/tratamento farmacológico
Glucocorticoides/uso terapêutico
Cefaleia
Seres Humanos
Linfo-Histiocitose Hemofagocítica/tratamento farmacológico
Masculino
Fotofobia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids); 7S5I7G3JQL (Dexamethasone)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170410
[St] Status:MEDLINE


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[PMID]:28338564
[Au] Autor:Tyler CW; Likova LT
[Ad] Endereço:*DSc †PhD Smith-Kettlewell Eye Research Institute, San Francisco, California (CWT, LTL); and Centre for Applied Vision Research, Division of Optometry and Vision Science, City University, London, United Kingdom (CWT).
[Ti] Título:Studying the Retinal Source of Photophobia by Facial Electroretinography.
[So] Source:Optom Vis Sci;94(4):511-518, 2017 Apr.
[Is] ISSN:1538-9235
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Photophobia is a debilitating clinical condition that disrupts the ability to use vision for everyday tasks in bright lighting conditions. The goal of the study is to develop a methodology to study the neural basis of photophobia and the contribution of the melanopic pathway to its etiology with differential chromatic responses by means of standard electroencephalographic recording equipment. METHODS: We introduce and validate the approach of recording wavelength-specific electroretinographic (ERG) responses from the face electrodes of the high-density whole-head electroencephalography recording system under light-adapted conditions. RESULTS: ERGs recorded in this way to whole-field chromatic stimuli exhibit striking differences between the photophobic and non-photophobic groups. The control responses were consistent with photopic intensity in peak time, and in the ordering of peak times as a function of wavelength condition, indicating a predominantly cone source of the signals. The photophobic responses, on the other hand, were substantially slowed relative to controls, with the peak times conforming to a different order as a function of wavelength condition than controls, implying that the cone response has been suppressed and that the responses derived from a different photoreceptor system consistent with mediation by melanopic retinal ganglion cells. CONCLUSIONS: The results will be important for determining the neural pathways involved in photophobia and potential approaches to its treatment on the basis of this etiology.
[Mh] Termos MeSH primário: Eletrorretinografia
Fotofobia/diagnóstico
Células Fotorreceptoras Retinianas Cones/patologia
Células Ganglionares da Retina/patologia
[Mh] Termos MeSH secundário: Adaptação Ocular
Eletroencefalografia/instrumentação
Face
Seres Humanos
Luz
Células Fotorreceptoras Retinianas Cones/metabolismo
Células Ganglionares da Retina/metabolismo
Opsinas de Bastonetes/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Rod Opsins); 0 (melanopsin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE
[do] DOI:10.1097/OPX.0000000000001064


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[PMID]:28329493
[Au] Autor:Ferrari B; Morita L; Choate K; Hu RH
[Ad] Endereço:Pediatric Dermatology Section, Hospital Ramos Mejía. Buenos Aires, Argentina. brunoferraripiel@gmail.com.
[Ti] Título:Ichthyosis follicularis with alopecia and photophobia syndrome (IFAP): A Case Report.
[So] Source:Dermatol Online J;23(2), 2017 Feb 15.
[Is] ISSN:1087-2108
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:IFAP syndrome is a rare autosomal recessive X-linked disease characterized by the triad of alopecia universalis, severe photophobia, and follicular ichthyosis. It is caused by loss of function of the gene MBTPS2. Its severity varies and there are only a few reports in the literature. We present a patient with characteristic clinical features and a mutation not previously reported.
[Mh] Termos MeSH primário: Alopecia/diagnóstico
Ictiose/diagnóstico
Fotofobia/diagnóstico
[Mh] Termos MeSH secundário: Alopecia/genética
Seres Humanos
Ictiose/genética
Lactente
Masculino
Metaloendopeptidases/genética
Fotofobia/genética
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.4.24.- (Metalloendopeptidases); EC 3.4.24.85 (MBTPS2 protein, human)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE


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[PMID]:28251921
[Au] Autor:Ksendzovsky A; Pomeraniec IJ; Zaghloul KA; Provencio JJ; Provencio I
[Ad] Endereço:From the Departments of Neurological Surgery (A.K., I.J.P.) and Neurology and Neuroscience (J.J.P.), University of Virginia Health Sciences Center, Charlottesville; Surgical Neurology Branch (A.K., K.A.Z.), National Institutes of Neurological Disorders and Stroke, NIH, Bethesda, MD; and the Departme
[Ti] Título:Clinical implications of the melanopsin-based non-image-forming visual system.
[So] Source:Neurology;88(13):1282-1290, 2017 Mar 28.
[Is] ISSN:1526-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Since the discovery of the non-image-forming visual system, tremendous research efforts have been dedicated to understanding its mechanisms and functional roles. Original functions associated with the melanopsin system include the photoentrainment of circadian sleep-wake cycles and the pupillary light reflex. Recent findings, however, suggest a much broader involvement of this system in an array of physiologic responses to light. This newfound insight into the underlying function of the non-image-forming system has revealed the many connections to human pathology and attendant disease states, including seasonal affective disorder, migraine, glaucoma, inherited mitochondrial optic neuropathy, and sleep dysregulation of aging. In this review, the authors discuss in detail the clinical implications of the melanopsin system.
[Mh] Termos MeSH primário: Ritmo Circadiano/fisiologia
Oftalmopatias
Opsinas de Bastonetes/metabolismo
Vias Visuais/metabolismo
[Mh] Termos MeSH secundário: Animais
Oftalmopatias/complicações
Oftalmopatias/metabolismo
Oftalmopatias/patologia
Seres Humanos
Luz
Fotofobia/metabolismo
Transtorno Afetivo Sazonal
Transtornos do Sono-Vigília
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Rod Opsins); 0 (melanopsin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170303
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000003761


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[PMID]:28185159
[Au] Autor:Seidel S; Beisteiner R; Manecke M; Aslan TS; Wöber C
[Ad] Endereço:Department of Neurology, Medical University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria. Stefan.seidel@meduniwien.ac.at.
[Ti] Título:Psychiatric comorbidities and photophobia in patients with migraine.
[So] Source:J Headache Pain;18(1):18, 2017 Dec.
[Is] ISSN:1129-2377
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Based on recent findings and our own impressions we took a closer look at the relationship between (inter)ictal photophobia and psychometric variables in migraine patients with photophobia. FINDINGS: For this study we included 29 (27 female) migraine patients and 31 (18 female) controls with a mean age of 31.6 ± 12.5 years and 24.0 ± 4.1 years, respectively. All participants filled out the Depression Anxiety Stress Scale (DASS). Interictal photophobia in patients was significantly higher than photophobia in controls (p = .001). Patients showed statistically significantly higher levels of depressive symptoms (p < .001), anxiety symptoms (p < .001) and stress (p < .001) than controls. Among all participants, (interictal) photophobia correlated positively with age (rho = .318, p = .013) as well as with the levels of depressive symptoms (rho = .459, p < .001), anxiety symptoms (rho = .346, p = .008) and stress (rho = .368, p = .005), but not with gender. In the patients, ictal photophobia correlated positively with age (rho = .473, p = .01) and interictal photophobia (rho = .423, p = .022). Linear regression analysis revealed only a trend towards statistical significance for (interictal) photophobia as a predictor for the level of depressive symptoms (rho = .457, p = 0.056) in the whole sample. CONCLUSIONS: Considering higher levels of photophobia in depression and the comorbidity of migraine and depression, it might be possible that depression contributes to interictal photophobia in patients with migraine. The same may be true for anxiety and stress. Both are also related to migraine and their possible impact on photophobia in migraine may be explained by pupillary dysfunction.
[Mh] Termos MeSH primário: Ansiedade/epidemiologia
Depressão/epidemiologia
Transtornos de Enxaqueca/epidemiologia
Transtornos de Enxaqueca/psicologia
Fotofobia/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Ansiedade/diagnóstico
Ansiedade/fisiopatologia
Comorbidade
Depressão/diagnóstico
Depressão/fisiopatologia
Feminino
Seres Humanos
Masculino
Transtornos de Enxaqueca/fisiopatologia
Estimulação Luminosa
Fotofobia/diagnóstico
Fotofobia/fisiopatologia
Prevalência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE
[do] DOI:10.1186/s10194-017-0718-1


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[PMID]:28137823
[Au] Autor:Shoughy SS; Tabbara KF
[Ad] Endereço:The Eye Center and the Eye Foundation for Research in Ophthalmology, Riyadh, Saudi Arabia.
[Ti] Título:Topical tacrolimus solution in autoimmune polyglandular syndrome-1-associated keratitis.
[So] Source:Br J Ophthalmol;101(9):1230-1233, 2017 Sep.
[Is] ISSN:1468-2079
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To evaluate the efficacy of topical tacrloimus eye drops in the treatment of keratitis associated with autoimmune polyglandular syndrome (APS)-1. METHODS: This is a retrospective review of 10 patients with APS-1. The patients were treated with topical tacrolimus 0.01% solution at The Eye Center, between 1 March 2012 and 30 April 2016. The outcome measures included improvement in visual acuity, photophobia and keratitis following treatment. Clinical assessment was carried out before, during and on the last visit following initiation of therapy. RESULTS: A total of 10 patients were included. There were five male and five female patients. The mean age was 11 years with age range of 3-42 years. The mean duration of treatment with topical tacrolimus was 26 months (range 8-46 months). There was improvement of photophobia in 7 out of 10 patients following therapy with topical tacrolimus. In three patients, the photophobia was persistent. There was no clinically detectable improvement in the severity of keratitis in all patients. The mean best corrected visual acuity was 0.1 before and following therapy. CONCLUSION: Topical tacrolimus is effective in reducing the photophobia in patients with APS-1-associated keratitis, but showed no effects on the severity of keratitis.
[Mh] Termos MeSH primário: Imunossupressores/administração & dosagem
Ceratite/tratamento farmacológico
Poliendocrinopatias Autoimunes/tratamento farmacológico
Tacrolimo/administração & dosagem
[Mh] Termos MeSH secundário: Administração Tópica
Adolescente
Adulto
Criança
Pré-Escolar
Feminino
Seres Humanos
Ceratite/diagnóstico
Ceratite/fisiopatologia
Masculino
Soluções Oftálmicas
Fotofobia/tratamento farmacológico
Poliendocrinopatias Autoimunes/diagnóstico
Poliendocrinopatias Autoimunes/fisiopatologia
Estudos Retrospectivos
Resultado do Tratamento
Acuidade Visual/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunosuppressive Agents); 0 (Ophthalmic Solutions); WM0HAQ4WNM (Tacrolimus)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE
[do] DOI:10.1136/bjophthalmol-2016-309808


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[PMID]:28057644
[Au] Autor:Al-Hemidan A; Shoughy SS; Kozak I; Tabbara KF
[Ad] Endereço:Habib Medical Group, Ophthalmology Department, Riyadh, Saudi Arabia.
[Ti] Título:Efficacy of topical cysteamine in nephropathic cystinosis.
[So] Source:Br J Ophthalmol;101(9):1234-1237, 2017 Sep.
[Is] ISSN:1468-2079
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The aim of this study is to evaluate the efficacy of topical cysteamine 0.55% eye drops in the treatment of corneal cystine crystal deposits in patients with nephropathic cystinosis. METHODS: Thirty-two patients with nephropathic cystinosis were prospectively included in the study. Patients with corneal cystinosis were treated with topical cysteamine 0.55% eye drops. They were examined before treatment, on each monthly visit and after treatment at the last follow-up. Photophobia was classified as grade 0 (none) for no photophobia, grade 1 (mild) for photophobia in bright light, grade 2 (moderate) for photophobia in room light and grade 3 (severe) for photophobia in dim light. Corneal cystine crystals were graded as grade 0=none, grade 1=1-10 crystals/mm , grade 2=11-50 crystals/mm , grade 3=more than 50 crystals/mm . The main outcome measure was evaluation of photophobia and resolution of corneal cystine crystals. RESULTS: There were 13 male and 19 female patients. The mean age was 8 years with an age range of 8 months to 19 years. The mean follow-up period was 4.1 years with a range of 2-8 years. Improvement of photophobia was not clinically significant in symptomatic patients. Patients displayed statistically significant worsening of corneal cystine deposits during the follow-up period. CONCLUSIONS: This study has shown that topical 0.55% cysteamine eye drops may have limited effects in decreasing the corneal cystine deposits in patients with severe forms of nephropathic cystinosis. TRIAL REGISTRATION NUMBER: NCT02766855, Results.
[Mh] Termos MeSH primário: Doenças da Córnea/tratamento farmacológico
Cisteamina/administração & dosagem
Eliminadores de Cistina/administração & dosagem
Cistinose/tratamento farmacológico
[Mh] Termos MeSH secundário: Administração Tópica
Adolescente
Criança
Pré-Escolar
Doenças da Córnea/diagnóstico
Doenças da Córnea/fisiopatologia
Cistinose/diagnóstico
Cistinose/fisiopatologia
Feminino
Seguimentos
Seres Humanos
Lactente
Masculino
Soluções Oftálmicas
Fotofobia/fisiopatologia
Estudos Prospectivos
Resultado do Tratamento
Acuidade Visual/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cystine Depleting Agents); 0 (Ophthalmic Solutions); 5UX2SD1KE2 (Cysteamine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170107
[St] Status:MEDLINE
[do] DOI:10.1136/bjophthalmol-2016-309278



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