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[PMID]:29282563
[Au] Autor:Kadavath Meethal NS; Mazumdar D; Asokan R; Panday M; van der Steen J; Vermeer KA; Lemij HG; George RJ; Pel JJM
[Ad] Endereço:Medical and Vision Research Foundation, Chennai, India.
[Ti] Título:Development of a test grid using Eye Movement Perimetry for screening glaucomatous visual field defects.
[So] Source:Graefes Arch Clin Exp Ophthalmol;256(2):371-379, 2018 Feb.
[Is] ISSN:1435-702X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Eye Movement Perimetry (EMP) uses Saccadic Eye Movement (SEM) responses for visual field evaluation. Previous studies have demonstrated significant delay in initiation of SEMs among glaucoma patients in comparison with healthy subjects. The aim of the current study was to develop an EMP-based screening grid to identify glaucomatous visual field defects. METHODS: An interactive test consisting of 36 locations and two stimulus contrasts (162 cd/m and 190 cd/m on a background of 140 cd/m ) was evaluated in 54 healthy subjects and 50 primary glaucoma patients. Each subject was presented a central fixation target combined with the random projection of Goldmann size III peripheral targets. Instructions were given to look at each peripheral target on detection and then re-fixate at the central fixation target while the saccades were assessed using an eye tracker. From each seen peripheral target, the Saccadic Reaction Time (SRT) was calculated for contrast level 162 cd/ m . These values were used to plot Receiver Operating Characteristic (ROC) curves for each test locations and the Area Under the Curve (AUC) values were used to identify the locations with highest susceptibility to glaucomatous damage. Each stimulus location with an AUC less than 0.75 along with its mirrored test location around the horizontal axis were eliminated from the grid. RESULTS: The mean age was 48.1 ± 16.6 years and 50.0 ± 14.5 years for healthy subjects and glaucoma patients respectively. A significant increase of SRT values by 76.5% (p < 0.001) was found in glaucoma patients in comparison with the healthy subjects. From the ROC analysis, ten out of 36 locations meeting the cut-off criteria of AUC were eliminated resulting in a new grid containing 26 test locations. SRT values were significantly different (p < 0.05) between the healthy subjects and glaucoma irrespective of the grids used. CONCLUSIONS: The present study resulted in a screening grid consisting of 26 locations predominantly testing nasal, superior and inferior areas of the visual field. An internal validation of the modified grid showed 90.4% of screening accuracy which makes it a potential approach for population based glaucoma screening.
[Mh] Termos MeSH primário: Movimentos Oculares
Glaucoma/complicações
Escotoma/diagnóstico
Seleção Visual/métodos
Testes de Campo Visual/métodos
Campos Visuais/fisiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Glaucoma/diagnóstico
Glaucoma/fisiopatologia
Seres Humanos
Incidência
Índia/epidemiologia
Masculino
Meia-Idade
Curva ROC
Reprodutibilidade dos Testes
Escotoma/epidemiologia
Escotoma/etiologia
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE
[do] DOI:10.1007/s00417-017-3872-x


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[PMID]:28451988
[Au] Autor:Badhani A; Padhi TR; Panda GK; Mukherjee S; Das T; Jalali S
[Ad] Endereço:Department of Vitreoretinal services, LV Prasad Eye Institute, Bhubaneswar, Odisha, India.
[Ti] Título:Correlation of macular structure and function in a boy with primary foveomacular retinitis and sequence of changes over 5 years.
[So] Source:Doc Ophthalmol;135(1):43-52, 2017 08.
[Is] ISSN:1573-2622
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To describe the clinical characteristics, macular structure and function, and to document sequential changes over 5 years in a 10-year-old boy with bilateral primary foveomacular retinitis. METHODS: A 10-year-old boy presented with sudden onset scotoma in both eyes, experienced after getting up from bed on a non-eclipse day. He persistently denied direct sun-gazing. He neither had any significant systemic illness, nor was using any medications. In addition to a detailed examination at presentation that included fundus fluorescein angiogram (FFA), electroretinogram (ERG), pattern ERG and electrooculogram (EOG), he was examined periodically for 5 years with Humphrey visual field (HVF), spectral domain optical coherence tomogram (SDOCT), Amsler grid charting and multifocal ERG. The macular structure and functions were analyzed over the years and correlated with the symptoms. RESULTS: All findings were bilaterally symmetrical at each visit. At presentation, his corrected visual acuity was 20/25 with subfoveal yellow dot similar to solar retinopathy, central scotoma with reduced foveal threshold in HVF 24-2, micropsia in Amsler grid, missing of two plates on Ishihara color vision chart, transfoveal full thickness hyper-reflective band on SD OCT, unremarkable FFA and normal foveal peak in mfERG. The flash ERG and EOG were unremarkable. A month later, his VA improved to 20/20, he had relative scotoma in Amsler grid, no scotoma in HVF (10-2), restoration of the inner segment of the photoreceptors with sharp defect involving ellipsoid and photoreceptor interdigitation zone in SDOCT and blunting of foveal peaks in mfERG. Three months later, his corrected VA was 20/20 with relative scotoma in Amsler grid, normal color vision, no scotoma in HVF 10-2 and unchanged SDOCT findings. In subsequent examinations at 6, 9, 14, 29, 39 and 60 months, he was symptomless with VA 20/20, unremarkable fundus, normal Amsler grid and HVF (normal foveal threshold), unchanged SDOCT findings and the reduced foveal peaks on mfERG in both eyes got normalized only at 60 months. CONCLUSION: Presented here is a case of bilaterally symmetrical idiopathic foveomacular retinitis that had a clinical appearance similar to solar retinopathy. The fundus changes persisted for 4 weeks, the symptoms and changes in Amsler grid lasted for 3 months, and the foveal threshold in visual fields normalized within 3 months. Maximum change in the SDOCT defect occurred within a month, and the extrafoveal defect in the ellipsoid and photoreceptor interdigitation line persisted despite resolution of symptoms and resolution of the visual field defect and normal distance vision. Probably, the foveal lesion detected on SDOCT was too small to cause a reduction in the distance visual acuity or show up in the visual field and mfERG later.
[Mh] Termos MeSH primário: Fóvea Central/fisiopatologia
Retinite/fisiopatologia
Escotoma/fisiopatologia
[Mh] Termos MeSH secundário: Criança
Eletroculografia
Eletrorretinografia
Angiofluoresceinografia
Seguimentos
Seres Humanos
Masculino
Retinite/diagnóstico
Escotoma/diagnóstico
Estatística como Assunto
Tomografia de Coerência Óptica
Acuidade Visual/fisiologia
Testes de Campo Visual
Campos Visuais/fisiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1007/s10633-017-9590-1


  3 / 2539 MEDLINE  
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[PMID]:29240745
[Au] Autor:Ramachandran N; Bhikoo R; Ah-Chan J; Bradshaw H
[Ad] Endereço:Ophthalmology Registrar, Southern DHB.
[Ti] Título:Waking up to poor vision after a night out.
[So] Source:N Z Med J;130(1467):87-89, 2017 12 15.
[Is] ISSN:1175-8716
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Mh] Termos MeSH primário: Retina/fisiopatologia
Escotoma/diagnóstico por imagem
Manobra de Valsalva
Baixa Visão/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Diagnóstico Diferencial
Seres Humanos
Masculino
Escotoma/etiologia
Tomografia de Coerência Óptica
Baixa Visão/etiologia
Acuidade Visual
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE


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[PMID]:28450381
[Au] Autor:Aoki S; Murata H; Fujino Y; Matsuura M; Miki A; Tanito M; Mizoue S; Mori K; Suzuki K; Yamashita T; Kashiwagi K; Hirasawa K; Shoji N; Asaoka R
[Ad] Endereço:Department of Ophthalmology, The University of Tokyo, Tokyo, Japan.
[Ti] Título:Investigating the usefulness of a cluster-based trend analysis to detect visual field progression in patients with open-angle glaucoma.
[So] Source:Br J Ophthalmol;101(12):1658-1665, 2017 12.
[Is] ISSN:1468-2079
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIMS: To investigate the usefulness of the Octopus (Haag-Streit) EyeSuite's cluster trend analysis in glaucoma. METHODS: Ten visual fields (VFs) with the Humphrey Field Analyzer (Carl Zeiss Meditec), spanning 7.7 years on average were obtained from 728 eyes of 475 primary open angle glaucoma patients. Mean total deviation (mTD) trend analysis and EyeSuite's cluster trend analysis were performed on various series of VFs (from 1st to 10th: VF1-10 to 6th to 10th: VF6-10). The results of the cluster-based trend analysis, based on different lengths of VF series, were compared against mTD trend analysis. RESULT: Cluster-based trend analysis and mTD trend analysis results were significantly associated in all clusters and with all lengths of VF series. Between 21.2% and 45.9% (depending on VF series length and location) of clusters were deemed to progress when the mTD trend analysis suggested no progression. On the other hand, 4.8% of eyes were observed to progress using the mTD trend analysis when cluster trend analysis suggested no progression in any two (or more) clusters. CONCLUSION: Whole field trend analysis can miss local VF progression. Cluster trend analysis appears as robust as mTD trend analysis and useful to assess both sectorial and whole field progression. Cluster-based trend analyses, in particular the definition of two or more progressing cluster, may help clinicians to detect glaucomatous progression in a timelier manner than using a whole field trend analysis, without significantly compromising specificity.
[Mh] Termos MeSH primário: Glaucoma de Ângulo Aberto/complicações
Pressão Intraocular
Escotoma/diagnóstico
Campos Visuais
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Análise por Conglomerados
Progressão da Doença
Feminino
Glaucoma de Ângulo Aberto/diagnóstico
Glaucoma de Ângulo Aberto/fisiopatologia
Seres Humanos
Masculino
Meia-Idade
Curva ROC
Estudos Retrospectivos
Escotoma/etiologia
Escotoma/fisiopatologia
Testes de Campo Visual
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180203
[Lr] Data última revisão:
180203
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1136/bjophthalmol-2016-310069


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[PMID]:29207977
[Au] Autor:Kuo YC; Chen N; Tsai RK
[Ad] Endereço:Department of Ophthalmology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
[Ti] Título:Acute Zonal Occult Outer Retinopathy (AZOOR): a case report of vision improvement after intravitreal injection of Ozurdex.
[So] Source:BMC Ophthalmol;17(1):236, 2017 Dec 06.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: AZOOR was first described by Gass in 1993 as a syndrome with rapid loss of one or more extensive zones of the outer retinal segments. It is characterized by photopsia, minimal funduscopic changes, and electroretinographic abnormalities. The efficacy of systemic steroids in treating AZOOR has been previously described and advocated by the concept of autoimmune retinopathy. However, the use of intravitreal of sustained-released steroid had not been mentioned to date. CASE PRESENTATION: A 34-year-old man had sudden onset of central scotoma and photopsia in the left eye. His visual acuity continued deteriorating. The visual field defect demonstrated bilateral enlarged blind spots and altitudinal defects. Fluorescein angiography (FA) showed nonspecific retinal inflammation, and an electroretinogram (ERG) illustrated decreased amplitude of the b wave in both eyes. Optical coherence tomography (OCT) examinations revealed parafoveal loss of the photoreceptor inner/outer segment (IS/OS) junction. Therefore, acute zonal occult outer retinopathy (AZOOR) was diagnosed. Although his vision did not improve under the initial treatment of systemic corticosteroid and calcium channel blocker, remarkable improvement was noticed after the intravitreal injection(IVI) of Ozurdex, consistent with the recovered IS/OS junction disruption. CONCLUSIONS: We herein report a typical case of AZOOR, suggesting that the intravitreal injection of steroid may benefit in certain patients.
[Mh] Termos MeSH primário: Anti-Inflamatórios/administração & dosagem
Dexametasona/administração & dosagem
Escotoma/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Injeções Intravítreas
Masculino
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 7S5I7G3JQL (Dexamethasone)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-017-0638-5


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[PMID]:29196760
[Au] Autor:Barraza-Bernal MJ; Rifai K; Wahl S
[Ad] Endereço:Institute for Ophthalmic Research, Eberhard Karls University, Tuebingen, Germany.
[Ti] Título:Transfer of an induced preferred retinal locus of fixation to everyday life visual tasks.
[So] Source:J Vis;17(14):2, 2017 Dec 01.
[Is] ISSN:1534-7362
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Subjects develop a preferred retinal locus of fixation (PRL) under simulation of central scotoma. If systematic relocations are applied to the stimulus position, PRLs manifest at a location in favor of the stimulus relocation. The present study investigates whether the induced PRL is transferred to important visual tasks in daily life, namely pursuit eye movements, signage reading, and text reading. Fifteen subjects with normal sight participated in the study. To develop a PRL, all subjects underwent a scotoma simulation in a prior study, where five subjects were trained to develop the PRL in the left hemifield, five different subjects on the right hemifield, and the remaining five subjects could naturally chose the PRL location. The position of this PRL was used as baseline. Under central scotoma simulation, subjects performed a pursuit task, a signage reading task, and a reading-text task. In addition, retention of the behavior was also studied. Results showed that the PRL position was transferred to the pursuit task and that the vertical location of the PRL was maintained on the text reading task. However, when reading signage, a function-driven change in PRL location was observed. In addition, retention of the PRL position was observed over weeks and months. These results indicate that PRL positions can be induced and may further transferred to everyday life visual tasks, without hindering function-driven changes in PRL position.
[Mh] Termos MeSH primário: Fixação Ocular/fisiologia
Retina/fisiologia
Escotoma/fisiopatologia
Acuidade Visual
Campos Visuais/fisiologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Leitura
Análise e Desempenho de Tarefas
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171203
[St] Status:MEDLINE
[do] DOI:10.1167/17.14.2


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[PMID]:29204647
[Au] Autor:Costela FM; Kajtezovic S; Woods RL
[Ad] Endereço:Schepens Eye Research Institute, Massachusetts Eye and Ear, Boston, Massachusetts, United States.
[Ti] Título:The Preferred Retinal Locus Used to Watch Videos.
[So] Source:Invest Ophthalmol Vis Sci;58(14):6073-6081, 2017 Dec 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: Eccentric viewing is a common strategy used by people with central vision loss (CVL) to direct the eye such that the image falls onto functioning peripheral retina, known as the preferred retinal locus (PRL). It has been long acknowledged that we do not know whether the PRL used in a fixation test is also used when performing tasks. We present an innovative method to determine whether the same PRL observed during a fixation task was used to watch videos and whether poor resolution affects gaze location. Methods: The gaze of a group of 60 normal vision (NV) observers was used to define a democratic center of interest (COI) of video clips from movies and television. For each CVL participant (N = 20), we computed the gaze offsets from the COI across the video clips. The distribution of gaze offsets of the NV participants was used to define the limits of NV behavior. If the gaze offset was within this 95% degree confidence interval, we presumed that the same PRL was used for fixation and video watching. Another 15 NV participants watched the video clips with various levels of defocus blur. Results: CVL participants had wider gaze-offset distributions than NV participants (P < 0.001). Gaze offsets of 18/20 CVL participants were outside the NV confidence interval. Further, none of the 15 NV participants watching the same videos with spherical defocus blur had a gaze offset that was decentered (outside the NV confidence interval), suggesting that resolution was not the problem. Conclusions: This indicates that many CVL participants were using a PRL to view videos that differed from that found with a fixation task and that it was not caused by poor resolution alone. The relationship between these locations needs further investigation.
[Mh] Termos MeSH primário: Movimentos Oculares/fisiologia
Filmes Cinematográficos
Retina/fisiopatologia
Escotoma/fisiopatologia
Acuidade Visual
Campos Visuais/fisiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Fixação Ocular
Voluntários Saudáveis
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-21839


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[PMID]:28837721
[Au] Autor:Martin GC; Dénier C; Zambrowski O; Grévent D; Bruère L; Brousse V; de Montalembert M; Brémond-Gignac D; Robert MP
[Ad] Endereço:Ophthalmology Department, Necker-Enfants Malades University Hospital, APHP, Paris, France.
[Ti] Título:Visual Function in Asymptomatic Patients With Homozygous Sickle Cell Disease and Temporal Macular Atrophy.
[So] Source:JAMA Ophthalmol;135(10):1100-1105, 2017 Oct 01.
[Is] ISSN:2168-6173
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Temporal macular involvement in sickle cell disease can now easily be detected by optical coherence tomography (OCT). However, while recent studies have demonstrated its high prevalence, little is known about its potential consequences on visual function. Objective: To assess the visual function of patients with sickle cell disease with no visual symptoms despite temporal macular atrophy. Design, Setting, and Participants: This retrospective case series included data collection and explorations made in a single referral center for sickle cell disease in 2016. Three patients with sickle cell disease exhibiting preserved visual acuity but showing temporal macular retinal atrophy were included. Exposures: Patients underwent the following explorations: best-corrected distance and near visual acuity evaluation; dilated fundus examination; OCT with 12 × 6-mm thickness map; horizontal, vertical, and en face sections; OCT angiography of the 6 × 6-mm perifoveal retina; 30° and 12° central visual fields; Lanthony 15-hue color vision test; automated static contrast sensitivity test; and global electroretinography. Main Outcomes and Measures: The OCT thickness maps were checked for areas of retinal thinning, appearing as blue patches. When present, these areas were compared with the areas of superficial and deep capillary flow loss on OCT angiography and with the scotomas on visual fields. Contrast sensitivity and color vision loss were quantified. Results: All 3 patients included had homozygous sickle cell disease. They presented with a 20/20 distance visual acuity, and Parinaud 1,5 near visual acuity in both eyes. They were all followed up for a severe cerebral vasculopathy related to sickle cell disease. The areas of atrophy involved the inner retinal layers and were associated with an absence of signal in the deep capillary plexuses in OCT angiography. These patches of retinal thinning were also matching with scotomas in the automated visual fields. Color vision ability and contrast sensitivity were impaired in all patients. Global electroretinography findings were normal. Conclusions and Relevance: Temporal macular atrophy in sickle cell disease may have direct consequences on visual function, including in children, even when visual acuity is preserved. Optical coherence tomographic imaging may be warranted when evaluating patients with sickle cell disease, even if asymptomatic with 20/20 visual acuity.
[Mh] Termos MeSH primário: Anemia Falciforme/fisiopatologia
Doenças Assintomáticas
Defeitos da Visão Cromática/fisiopatologia
Macula Lutea/patologia
Escotoma/fisiopatologia
Acuidade Visual/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Atrofia
Criança
Angiografia por Tomografia Computadorizada
Sensibilidades de Contraste/fisiologia
Seres Humanos
Masculino
Estudos Retrospectivos
Tomografia de Coerência Óptica
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170825
[St] Status:MEDLINE
[do] DOI:10.1001/jamaophthalmol.2017.3008


  9 / 2539 MEDLINE  
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[PMID]:28810043
[Au] Autor:Garrity ST; Holz EJ; Sarraf D
[Ti] Título:Amalric Triangular Syndrome Associated With Outer Nuclear Layer Infarction.
[So] Source:Ophthalmic Surg Lasers Imaging Retina;48(8):668-670, 2017 Aug 01.
[Is] ISSN:2325-8179
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An 85-year-old man presented with temporal headache and bilateral paracentral scotomas. Clinical examination, laboratory testing, and temporal artery biopsy confirmed the diagnosis of giant cell arteritis. Fluorescein angiography illustrated Amalric triangular choroidal infarction of the left eye. Spectral-domain optical coherence tomography of the left eye demonstrated outer nuclear layer abnormalities adjacent to the choroidal infarct. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:668-670.].
[Mh] Termos MeSH primário: Doenças da Coroide/complicações
Corioide/irrigação sanguínea
Infarto/complicações
Escotoma/etiologia
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Doenças da Coroide/diagnóstico
Angiofluoresceinografia/métodos
Seguimentos
Fundo de Olho
Seres Humanos
Infarto/diagnóstico
Masculino
Escotoma/diagnóstico
Síndrome
Tomografia de Coerência Óptica/métodos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170816
[St] Status:MEDLINE
[do] DOI:10.3928/23258160-20170802-10


  10 / 2539 MEDLINE  
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[PMID]:28734817
[Au] Autor:Jung KI; Park CK
[Ad] Endereço:Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
[Ti] Título:Detection of Functional Change in Preperimetric and Perimetric Glaucoma Using 10-2 Matrix Perimetry.
[So] Source:Am J Ophthalmol;182:35-44, 2017 Oct.
[Is] ISSN:1879-1891
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To evaluate an effective functional strategy for detecting glaucomatous damage of the macula in preperimetric to perimetric glaucoma. DESIGN: Cross-sectional study. METHODS: Preperimetric glaucoma patients (n = 102) and perimetric glaucoma patients (n = 88) with isolated paracentral scotoma or combined paracentral scotoma were enrolled in this study. Global and sectoral mean sensitivities (MS) were evaluated using 10-2 standard automated perimetry (SAP) with a stimulus of sizes III (0.43-degree diameter) and V (1.72 degrees), and 10-2 Matrix perimetry with a stimulus of 2 degrees. Ganglion cell-inner plexiform layer (GCIPL) was measured using spectral-domain optical coherence tomography. RESULTS: The percentage of significantly depressed visual field (VF) points <5% and <1% in the pattern deviation plot was higher with frequency doubling technology (FDT) 10-2 than with SAP 10-2 III in patients with preperimetric glaucoma (both P < .001). Using FDT 10-2 tests, the global structure-function correlation was superior to SAP 10-2 (III or V) in both preperimetric and perimetric glaucoma. Topographic structure-function relationships for each VF test were more favorable with the FDT 10-2 test. The preperimetric glaucoma patients showing VF abnormalities on FDT 10-2 or SAP 10-2 (III) showed thinner average, minimum, superior, inferior, and inferotemporal GCIPL thicknesses than in those without VF abnormalities (all P < .05). CONCLUSIONS: FDT 10-2 was found to detect functional damage of the macula early in preperimetric glaucoma, and to perform better than with SAP 10-2 (size III or V) from preperimetric to perimetric glaucoma in the structure-function relationship. FDT 10-2 can be considered a useful tool to detect glaucomatous damage of the macula early and appropriately.
[Mh] Termos MeSH primário: Glaucoma de Ângulo Aberto/diagnóstico
Macula Lutea/fisiopatologia
Doenças Retinianas/diagnóstico
Escotoma/diagnóstico
Campos Visuais/fisiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Estudos Transversais
Feminino
Glaucoma de Ângulo Aberto/fisiopatologia
Gonioscopia
Seres Humanos
Pressão Intraocular/fisiologia
Masculino
Meia-Idade
Fibras Nervosas/patologia
Doenças Retinianas/fisiopatologia
Células Ganglionares da Retina/patologia
Escotoma/fisiopatologia
Tomografia de Coerência Óptica
Tonometria Ocular
Acuidade Visual/fisiologia
Testes de Campo Visual/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170724
[St] Status:MEDLINE



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