Base de dados : MEDLINE
Pesquisa : C10.668.829.050 [Categoria DeCS]
Referências encontradas : 541 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 55 ir para página                         

  1 / 541 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28490654
[Au] Autor:Masuda T; Ueda M; Suenaga G; Misumi Y; Tasaki M; Izaki A; Yanagisawa Y; Inoue Y; Motokawa H; Matsumoto S; Mizukami M; Arimura A; Deguchi T; Nishio Y; Yamashita T; Inomata Y; Obayashi K; Ando Y
[Ad] Endereço:From the Department of Neurology (T.M., M.U., G.S., Y.M., M.T., Y.I., H.M., S.M., M.M., T.Y., Y.A.) and Departments of Transplantation and Pediatric Surgery (Y.I.), Graduate School of Medical Sciences, and Department of Morphological and Physiological Sciences (M.T., A.I., Y.Y., K.O.), Graduate Scho
[Ti] Título:Early skin denervation in hereditary and iatrogenic transthyretin amyloid neuropathy.
[So] Source:Neurology;88(23):2192-2197, 2017 Jun 06.
[Is] ISSN:1526-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To elucidate early skin denervation in hereditary transthyretin (TTR) amyloidosis and iatrogenic TTR amyloidosis. METHODS: We investigated intraepidermal nerve fiber density (IENFD) and clinical findings in 32 patients with hereditary TTR amyloidosis, 11 asymptomatic mutation carriers, 6 patients with iatrogenic TTR amyloidosis, and 23 healthy volunteers. RESULTS: IENFD values were reduced in patients with the V30M mutation (1.9 ± 2.1 per 1 mm), patients with non-V30M mutations (5.8 ± 3.2 per 1 mm), and patients with iatrogenic TTR amyloidosis (3.5 ± 1.8 per 1 mm) compared with healthy volunteers (11.8 ± 3.2 per 1 mm) ( < 0.01). Skin denervation also occurred, even in presymptomatic V30M mutation carriers (5.0 ± 2.2 per 1 mm). The IENFD was correlated with disease duration (ρ = -0.533, = 0.002) and various peripheral neuropathy parameters such as sensory impairment in the Kumamoto clinical score (ρ = -0.575, = 0.001), heat-pain detection threshold (ρ = -0.704, < 0.001), and sural sensory nerve action potential (ρ = 0.481, = 0.005). TTR amyloid deposits frequently occurred in connective tissues and vessels of the dermal reticular layer in patients with hereditary TTR amyloidosis and those with iatrogenic TTR amyloidosis. CONCLUSIONS: Patients with hereditary TTR amyloidosis and those with iatrogenic TTR amyloidosis may show early skin denervation even in the presymptomatic stage. IENFD may thus be useful for early diagnosis and may serve as a biomarker in clinical trials for hereditary and iatrogenic TTR amyloidosis.
[Mh] Termos MeSH primário: Neuropatias Amiloides Familiares/patologia
Neuropatias Amiloides/patologia
Pré-Albumina/genética
Pele/inervação
Pele/patologia
[Mh] Termos MeSH secundário: Adulto
Diagnóstico Precoce
Feminino
Heterozigoto
Seres Humanos
Doença Iatrogênica
Masculino
Meia-Idade
Mutação
Sintomas Prodrômicos
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Prealbumin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000004016


  2 / 541 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27568093
[Au] Autor:Gonçalves NP; Gonçalves P; Magalhães J; Ventosa M; Coelho AV; Saraiva MJ
[Ad] Endereço:Instituto de Inovação e Investigação em Saúde (I3S), Universidade do Porto, Porto, Portugal; Molecular Neurobiology, Instituto de Biologia Molecular e Celular - IBMC, Porto, Portugal.
[Ti] Título:Tissue remodeling after interference RNA mediated knockdown of transthyretin in a familial amyloidotic polyneuropathy mouse model.
[So] Source:Neurobiol Aging;47:91-101, 2016 Nov.
[Is] ISSN:1558-1497
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Transthyretin (TTR) deposition in the peripheral nervous system is the hallmark of familial amyloidotic polyneuropathy (FAP). Currently, liver transplantation is the only available treatment to halt the progression of clinical symptoms; however, due to the limitations of this procedure, development of alternative therapeutic strategies is of utmost importance. In this regard, interference RNA (RNAi) targeting TTR is currently in phase III clinical development. To dissect molecular changes occurring in dorsal root ganglia (DRG) upon RNAi-mediated knockdown of TTR, we treated both chronically and acutely an FAP mouse model, in different stages of disease. Our data show that inhibition of TTR expression by the liver with RNAi reverse TTR deposition in DRG, decrease matrix metalloproteinase-2 (MMP-2) protein levels in plasma, inhibit Mmp-2 gene expression and downregulate MMP-9 activity in DRG, indicating extracellular matrix remodeling. Furthermore, protein levels of MMP-2 were found upregulated in plasma samples from FAP patients indicating that MMP-2 might be a novel potential biomarker for FAP diagnosis. Collectively, our data show that silencing TTR liver synthesis in vivo can modulate TTR-induced pathology in the peripheral nervous system and highlight the potential of MMP-2 as a novel disease biomarker.
[Mh] Termos MeSH primário: Neuropatias Amiloides/genética
Neuropatias Amiloides/patologia
Técnicas de Silenciamento de Genes
Pré-Albumina/genética
Pré-Albumina/metabolismo
Interferência de RNA
[Mh] Termos MeSH secundário: Neuropatias Amiloides/diagnóstico
Neuropatias Amiloides/terapia
Animais
Biomarcadores/metabolismo
Modelos Animais de Doenças
Matriz Extracelular/metabolismo
Gânglios Espinais/metabolismo
Gânglios Espinais/patologia
Expressão Gênica
Fígado/metabolismo
Metaloproteinase 2 da Matriz/genética
Metaloproteinase 2 da Matriz/metabolismo
Camundongos Transgênicos
Sistema Nervoso Periférico/metabolismo
Sistema Nervoso Periférico/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Prealbumin); EC 3.4.24.24 (Matrix Metalloproteinase 2)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160829
[St] Status:MEDLINE


  3 / 541 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27422051
[Au] Autor:Loavenbruck AJ; Singer W; Mauermann ML; Sandroni P; B Dyck PJ; Gertz M; Klein CJ; Low PA
[Ad] Endereço:Department of Neurology, Mayo Clinic, Rochester, MN.
[Ti] Título:Transthyretin amyloid neuropathy has earlier neural involvement but better prognosis than primary amyloid counterpart: an answer to the paradox?
[So] Source:Ann Neurol;80(3):401-11, 2016 Sep.
[Is] ISSN:1531-8249
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To systematically compare transthyretin with primary amyloid neuropathy to define their natural history and the underlying mechanisms for differences in phenotype and natural history. METHODS: All patients with defined amyloid subtype and peripheral neuropathy who completed autonomic testing and electromyography at Mayo Clinic Rochester between 1993 and 2013 were included. Medical records were reviewed for time of onset of defined clinical features. The degree of autonomic impairment was quantified using the composite autonomic severity scale. Comparisons were made between acquired and inherited forms of amyloidosis. RESULTS: One hundred one cases of amyloidosis with peripheral neuropathy were identified, 60 primary and 41 transthyretin. Twenty transthyretin cases were found to have Val30Met mutations; 21 had other mutations. Compared to primary cases, transthyretin cases had longer survival, longer time to diagnosis, higher composite autonomic severity scale scores, greater reduction of upper limb nerve conduction study amplitudes, more frequent occurrence of weakness, and later non-neuronal systemic involvement. Four systemic markers (cardiac involvement by echocardiogram, weight loss > 10 pounds, orthostatic intolerance, fatigue) in combination were highly predictive of poor survival in both groups. INTERPRETATION: These findings suggest that transthyretin has earlier and greater predilection for neural involvement and more delayed systemic involvement. The degree and rate of systemic involvement is most closely related to prognosis. Ann Neurol 2016;80:401-411.
[Mh] Termos MeSH primário: Neuropatias Amiloides/metabolismo
Neuropatias Amiloides/fisiopatologia
Amiloide/metabolismo
Pré-Albumina/metabolismo
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Mutação
Fenótipo
Pré-Albumina/genética
Prognóstico
Estudos Retrospectivos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amyloid); 0 (Prealbumin); 87090-18-4 (amyloid prealbumin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170902
[Lr] Data última revisão:
170902
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160717
[St] Status:MEDLINE
[do] DOI:10.1002/ana.24725


  4 / 541 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26843567
[Au] Autor:Furst AJ; Bigler ED
[Ad] Endereço:From the Departments of Psychiatry and Behavioral Sciences (A.J.F.) and Neurology and Neurological Sciences (A.J.F.), Stanford University School of Medicine, Stanford, CA; War Related Illness and Injury Study Center (WRIISC) (A.J.F.), VA Palo Alto Health Care System, Palo Alto, CA; and Department of Psychology (E.D.B.), Brigham Young University, Provo, UT. ajfurst@stanford.edu.
[Ti] Título:Amyloid plaques in TBI: Incidental finding or precursor for what is to come?
[So] Source:Neurology;86(9):798-9, 2016 Mar 01.
[Is] ISSN:1526-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Neuropatias Amiloides/diagnóstico
Neuropatias Amiloides/etiologia
Peptídeos beta-Amiloides/metabolismo
Axônios/patologia
Lesões Encefálicas/complicações
Lesões Encefálicas/diagnóstico
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:COMMENT; EDITORIAL
[Nm] Nome de substância:
0 (Amyloid beta-Peptides)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160301
[Lr] Data última revisão:
160301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160205
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000002426


  5 / 541 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:26843562
[Au] Autor:Scott G; Ramlackhansingh AF; Edison P; Hellyer P; Cole J; Veronese M; Leech R; Greenwood RJ; Turkheimer FE; Gentleman SM; Heckemann RA; Matthews PM; Brooks DJ; Sharp DJ
[Ad] Endereço:From the Division of Brain Sciences (G.S., A.F.R., P.E., P.H., J.C., R.L., S.M.G., R.A.H., P.M.M., D.J.B., D.J.S.), Department of Medicine, Imperial College London; Institute of Psychiatry, Psychology & Neuroscience (P.H., M.V., F.E.T.), King's College London; Institute of Neurology (R.J.G.), Un
[Ti] Título:Amyloid pathology and axonal injury after brain trauma.
[So] Source:Neurology;86(9):821-8, 2016 Mar 01.
[Is] ISSN:1526-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To image ß-amyloid (Aß) plaque burden in long-term survivors of traumatic brain injury (TBI), test whether traumatic axonal injury and Aß are correlated, and compare the spatial distribution of Aß to Alzheimer disease (AD). METHODS: Patients 11 months to 17 years after moderate-severe TBI underwent (11)C-Pittsburgh compound B ((11)C-PiB)-PET, structural and diffusion MRI, and neuropsychological examination. Healthy aged controls and patients with AD underwent PET and structural MRI. Binding potential (BPND) images of (11)C-PiB, which index Aß plaque density, were computed using an automatic reference region extraction procedure. Voxelwise and regional differences in BPND were assessed. In TBI, a measure of white matter integrity, fractional anisotropy, was estimated and correlated with (11)C-PiB BPND. RESULTS: Twenty-eight participants (9 with TBI, 9 controls, 10 with AD) were assessed. Increased (11)C-PiB BPND was found in TBI vs controls in the posterior cingulate cortex and cerebellum. Binding in the posterior cingulate cortex increased with decreasing fractional anisotropy of associated white matter tracts and increased with time since injury. Compared to AD, binding after TBI was lower in neocortical regions but increased in the cerebellum. CONCLUSIONS: Increased Aß burden was observed in TBI. The distribution overlaps with, but is distinct from, that of AD. This suggests a mechanistic link between TBI and the development of neuropathologic features of dementia, which may relate to axonal damage produced by the injury.
[Mh] Termos MeSH primário: Neuropatias Amiloides/diagnóstico
Neuropatias Amiloides/etiologia
Peptídeos beta-Amiloides/metabolismo
Axônios/patologia
Lesões Encefálicas/complicações
Lesões Encefálicas/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Neuropatias Amiloides/metabolismo
Biomarcadores/metabolismo
Lesões Encefálicas/metabolismo
Imagem de Tensor de Difusão/métodos
Feminino
Seres Humanos
Estudos Longitudinais
Masculino
Meia-Idade
Imagem Multimodal/métodos
Tomografia por Emissão de Pósitrons/métodos
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amyloid beta-Peptides); 0 (Biomarkers)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160205
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000002413


  6 / 541 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26831189
[Au] Autor:Bourque PR; Shafi S; Jansen GH; McCurdy A; Warman Chardon J
[Ad] Endereço:Division of Neurology, Department of Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada.
[Ti] Título:Amyloid Neuropathy Following Domino Liver Transplantation: Response to Diflunisal.
[So] Source:JAMA Neurol;73(4):477-8, 2016 Apr.
[Is] ISSN:2168-6157
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Neuropatias Amiloides/diagnóstico
Neuropatias Amiloides/tratamento farmacológico
Anti-Inflamatórios não Esteroides/uso terapêutico
Diflunisal/uso terapêutico
Transplante de Fígado/efeitos adversos
[Mh] Termos MeSH secundário: Idoso
Neuropatias Amiloides/etiologia
Seres Humanos
Transplante de Fígado/tendências
Masculino
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 7C546U4DEN (Diflunisal)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160412
[Lr] Data última revisão:
160412
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160203
[St] Status:MEDLINE
[do] DOI:10.1001/jamaneurol.2015.4715


  7 / 541 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26806028
[Au] Autor:Cruz S; Cortes-Vicente E; Illa I; Rojas-Garcia R
[Ad] Endereço:a Department of Neurology , Hospital Prof. Doutor Fernando Fonseca , Amadora , Portugal .
[Ti] Título:Transthyretin-related hereditary amyloid polyneuropathy presenting with large fibre involvement and cardiomyopathy.
[So] Source:Amyloid;23(1):64-5, 2016.
[Is] ISSN:1744-2818
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Neuropatias Amiloides/genética
Cardiomiopatias/genética
Pré-Albumina/genética
[Mh] Termos MeSH secundário: Adulto
Neuropatias Amiloides/patologia
Cardiomiopatias/patologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Mutação de Sentido Incorreto
Nervos Periféricos/patologia
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
0 (Prealbumin)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160126
[St] Status:MEDLINE
[do] DOI:10.3109/13506129.2015.1127223


  8 / 541 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26284768
[Au] Autor:Broski SM; Spinner RJ; Howe BM; Dispenzieri A; Johnson GB
[Ad] Endereço:From the Departments of *Radiology, †Neurosurgery, and ‡Orthopedics, §Division of Hematology, and ∥Department of Immunology, Mayo Clinic, Rochester, MN.
[Ti] Título:18F-Florbetapir and 18F-FDG PET/CT in Systemic Immunoglobulin Light Chain Amyloidosis Involving the Peripheral Nerves.
[So] Source:Clin Nucl Med;41(2):e115-7, 2016 Feb.
[Is] ISSN:1536-0229
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We present a case of both F-FDG and F-florbetapir uptake in a biopsy-confirmed immunoglobulin light chain (AL) amyloidosis involving the peripheral nerves. AL amyloidosis is the most common cause of acquired amyloid polyneuropathy, manifesting with both sensorimotor and autonomic neuronal dysfunction. Given the overlapping MRI and FDG PET/CT appearances of several different causes of peripheral neuropathy, F-florbetapir PET/CT provides another potential tool in the imaging algorithm of these patients and may guide targeted fascicular biopsy for pathologic confirmation.
[Mh] Termos MeSH primário: Neuropatias Amiloides/diagnóstico por imagem
Amiloidose/diagnóstico por imagem
Compostos de Anilina
Etilenoglicóis
Fluordesoxiglucose F18
Tomografia por Emissão de Pósitrons
Compostos Radiofarmacêuticos
Tomografia Computadorizada por Raios X
[Mh] Termos MeSH secundário: Seres Humanos
Amiloidose de Cadeia Leve de Imunoglobulina
Masculino
Meia-Idade
Imagem Multimodal
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aniline Compounds); 0 (Ethylene Glycols); 0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18); 6867Q6IKOD (florbetapir)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150819
[St] Status:MEDLINE
[do] DOI:10.1097/RLU.0000000000000947


  9 / 541 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26513367
[Au] Autor:Herrero L; Naranjo-Hans D; Solé M; Santamaría G; Bargalló X; Velasco M; Fernández PL
[Ad] Endereço:Department of Pathology, Hospital Clinic, University of Barcelona, Barcelona, Spain.
[Ti] Título:Amyloidosis of the Breast: Three Different and Unusual Presentations of a Rare Entity.
[So] Source:Pathobiology;82(6):264-8, 2015.
[Is] ISSN:1423-0291
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Amyloidosis involving the breast is a rare finding and it may present as a solitary mass called 'amyloid tumor'. According to the largest case series, the amyloid deposits are usually of the AL type (commonly x03BA; light chain). METHODS: We report 3 cases diagnosed at our institution in the period from 2000 to 2015. Radiological, histological and immunohistochemical studies were performed. RESULTS AND CONCLUSIONS: Together with a case presenting in a patient with multiple myeloma, we describe 2 unique presentations including 1 associated with CREST syndrome in a patient with a previous history of breast carcinoma and another, also associated with cancer, with transthyretin deposits in a woman with a TTR gene mutation and a family history of familial amyloidotic polyneuropathy. These cases are an example of the vast heterogeneity of this disorder regarding its clinical presentation, the type of amyloid deposits and other diseases associated with breast amyloidosis.
[Mh] Termos MeSH primário: Amiloidose/diagnóstico
Amiloidose/patologia
Mama/patologia
[Mh] Termos MeSH secundário: Idoso
Neuropatias Amiloides/complicações
Neuropatias Amiloides/congênito
Amiloidose/complicações
Mama/ultraestrutura
Neoplasias da Mama/complicações
Síndrome CREST/complicações
Síndrome CREST/diagnóstico por imagem
Síndrome CREST/patologia
Diagnóstico Diferencial
Feminino
Seres Humanos
Meia-Idade
Mieloma Múltiplo/complicações
Mutação
Pré-Albumina/genética
Radiografia
Doenças Raras
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Prealbumin)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151030
[St] Status:MEDLINE
[do] DOI:10.1159/000440866


  10 / 541 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26441223
[Au] Autor:Shao H; Mi Z; Ji WG; Zhang CH; Zhang T; Ren SC; Zhu ZR
[Ad] Endereço:Department of Physiology, Third Military Medical University, Gaotanyan Street 30, Chongqing, 400038, People's Republic of China.
[Ti] Título:Rhynchophylline Protects Against the Amyloid ß-Induced Increase of Spontaneous Discharges in the Hippocampal CA1 Region of Rats.
[So] Source:Neurochem Res;40(11):2365-73, 2015 Nov.
[Is] ISSN:1573-6903
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Accumulated soluble amyloid ß (Aß)-induced aberrant neuronal network activity has been recognized as a key causative factor leading to cognitive deficits which are the most outstanding characteristic of Alzheimer's disease (AD). As an important structure associated with learning and memory, the hippocampus is one of the brain regions that are impaired very early in AD, and the hippocampal CA1 region is selectively vulnerable to soluble Aß oligomers. Our recent study showed that soluble Aß1-42 oligomers induced hyperactivity and perturbed the firing patterns in hippocampal neurons. Rhynchophylline (RIN) is an important active tetracyclic oxindole alkaloid isolated from Uncaria rhynchophylla which is a traditional Chinese medicine and often used to treat central nervous system illnesses such as hypertension, convulsions, tremor, stroke etc. Previous evidence showed that RIN possessed neuroprotective effects of improving the cognitive function of mice with Alzheimer-like symptoms. In the present study, we aimed to investigate the protective effect of RIN against soluble Aß1-42 oligomers-induced hippocampal hyperactivity. The results showed that (1) the mean frequency of spontaneous discharge was increased by the local application of 3 µM soluble Aß1-42 oligomers; (2) 30 µM RIN did not exert any obvious effects on basal physiological discharges; and (3) treatment with RIN effectively inhibited the soluble Aß1-42 oligomers-induced enhancement of spontaneous discharge, in a concentration-dependent manner with an IC50 = 9.0 µM. These in vivo electrophysiological results indicate that RIN can remold the spontaneous discharges disturbed by Aß and counteract the deleterious effect of Aß1-42 on neural circuit. The experimental findings provide further evidence to affirm the potential of RIN as a worthy candidate for further development into a therapeutic agent for AD.
[Mh] Termos MeSH primário: Neuropatias Amiloides/prevenção & controle
Neuropatias Amiloides/fisiopatologia
Peptídeos beta-Amiloides/antagonistas & inibidores
Peptídeos beta-Amiloides/toxicidade
Região CA1 Hipocampal/efeitos dos fármacos
Região CA1 Hipocampal/fisiopatologia
Alcaloides de Indol/farmacologia
Fármacos Neuroprotetores/farmacologia
[Mh] Termos MeSH secundário: Neuropatias Amiloides/psicologia
Animais
Transtornos Cognitivos/induzido quimicamente
Transtornos Cognitivos/psicologia
Relação Dose-Resposta a Droga
Masculino
Fragmentos de Peptídeos/antagonistas & inibidores
Fragmentos de Peptídeos/toxicidade
Ratos
Ratos Sprague-Dawley
Uncaria/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amyloid beta-Peptides); 0 (Indole Alkaloids); 0 (Neuroprotective Agents); 0 (Peptide Fragments); 0 (amyloid beta-protein (1-42)); 46BQ79VJ8D (rhyncophylline)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151007
[St] Status:MEDLINE
[do] DOI:10.1007/s11064-015-1730-y



página 1 de 55 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde