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[PMID]:29378101
[Au] Autor:Serhiyenko VA
[Ti] Título:[Effects of omega-3 polyunsaturated fatty acids on the state of insulin resistance, the content of some pro- and antiinflammatory factors in patients with type 2 diabetes mellitus and cardiovascular autonomic neuropathy].
[So] Source:Vopr Pitan;84(6):76-82, 2015.
[Is] ISSN:0042-8833
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:We have investigated the influence of the long-chain ω-3 polyunsaturated fatty acids (ω-3 PUFA) administration on the insulin resistance parameters, levels of high sensitivity C-reactive protein (hsCRP), some pro- and anti-inflammatory cytokines in patients with type 2 diabetes mellitus (T2 DM) and cardiovascular autonomic neuropathy (CAN). The study involved 12 patients with T2 DM without verified cardiovascular diseases (CVD), 36 patients with T2 DM and functional stage of CAN, of median age 50­59 years, disease duration 1­6 years and HbA1c levels ­ 7.1±0.6%. 15 healthy subjects were control group. Screening for CAN, that included five standard cardiovascular tests, was performed. The levels of blood glucose, HbA1c, immunoreactive insulin (IRI), hsCRP, tumor necrosis factor α (TNFα), interleukin (IL)-6, IL-8 and IL-10 were measured. The index of insulin resistance (HOMA-IR) and TNFα/IL-10 ratio were calculated. Patients with T2 DM and CAN were divided into 2 groups: patients of the 1st group (group of comparison, n=15) received standard glucose-lowering therapy; patients of the 2nd group (n=21) received one capsule/day of the ω-3 PUFA (∼90% ethyl ester of PUFA (1000 mg), in particular eicosapentaenoic ­ 460 mg, docosahexaenoic acid ­ 380 mg and 4 mg α-tocopherol acetate) in addition to the standard therapy. The duration of the study was 3 months. Obtained results showed, that development of CAN in patients with T2 DM is accompanied by increase of the IRI (26.6±1.73 mcIU/ml, p<0.001 ­ compared to the control; p1<0.001 ­ compared to T2 DM patients without CVD); hsCRP (2.77±0.24 mg/l, p<0.001, p1<0,001); TNFα (5.75±0.24 pg/ml, p<0.001, p1<0.001); IL-6 (5.88±0.38 pg/ml, p<0.001, p1<0.001); IL-8 (6.65±0.3 pg/ml, p<0.001, p1>0.05); IL-10 (15.86±1.4 pg/ml, p<0.05, p1>0.05) levels; TNFα/IL-10 (44.2±3.57%, p<0.01, p1<0.05) and HOMA-IR. After 3 months of treatment no statistically significant changes (p>0.05) of investigated parameters, in particular levels of IRI (-6.8±2.0%); hsCRP (-7.2±1.63%); TNFα (-6.1±1.0%); IL-6 (-5.8±1.77%); IL-8 (-3.9±1.57%); IL-10 (-3.7±2.34%); TNFα/IL-10 (-0.5±2.3%) in patients from the group of comparison were found. The administration of ω-3 PUFA to patients with T2 DM and CAN promoted to the statistically significant decrease in hsCRP (-14.8±2.91%, p<0.05), TNFα (-14.1±2.15%, p<0.01), IL-6 (-13.5±2.7%, p<0.05), IL-8 (-9.8±2.13%, p<0.05), TNFα/IL-10 ratio (-34.6±1.93%, p<0.05); a slighty decrease in the content of the IRI (-10.3±1.1%, p>0.05), IL-10 (+7.9 ±6.42%, p>0.05), HOMA-IR was observed. Obtained results could witness, that prescription of ω-3 PUFA leads to decrease of the proinflammatory immune response activity and allows to consider ω-3 PUFA as a promising medicine in treatment and/or prevention of CAN in patients with DM 2.
[Mh] Termos MeSH primário: Doenças Cardiovasculares
Diabetes Mellitus Tipo 2
Neuropatias Diabéticas
Ácidos Graxos Ômega-3/administração & dosagem
Resistência à Insulina
[Mh] Termos MeSH secundário: Doenças Cardiovasculares/sangue
Doenças Cardiovasculares/tratamento farmacológico
Citocinas/sangue
Diabetes Mellitus Tipo 2/sangue
Diabetes Mellitus Tipo 2/tratamento farmacológico
Neuropatias Diabéticas/sangue
Neuropatias Diabéticas/tratamento farmacológico
Feminino
Seres Humanos
Inflamação/sangue
Inflamação/tratamento farmacológico
Mediadores da Inflamação/sangue
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Fatty Acids, Omega-3); 0 (Inflammation Mediators)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE


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[PMID]:29419686
[Au] Autor:Wang X; Lin H; Xu S; Jin Y; Zhang R
[Ad] Endereço:Shenzhen Bao'an Traditional Chinese Medicine Hospital Group, Guangzhou University of Chinese Medicine, Shenzhen.
[Ti] Título:The clinical efficacy of epalrestat combined with α-lipoic acid in diabetic peripheral neuropathy: Protocol for a systematic review and meta-analysis.
[So] Source:Medicine (Baltimore);97(6):e9828, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Diabetic peripheral neuropathy (DPN) is a common long-term complication of diabetes mellitus, affecting patients in the world. Epalrestat combined with α-lipoic acid (ALA) is the most frequent combine therapy used in the DPN researches. We aim to assess the effectiveness and safety of epalrestat combined with ALA in patients with DPN, compare with epalrestat alone. METHODS: We will search Cochrane Library, PubMed, Wanfang Data, China National Knowledge Infrastructure, VIP Chinese Science and Technology Journals Database, and Chinese Biomedical Database from inception until October 31th, 2017. Inclusion the randomized controlled trials and clinical control trials of combine therapy which evaluate clinical efficacy and side effect in people with DPN. Data extraction and risk of bias assessments will be independently conducted by 2 reviewers. The primary outcome measures will be total effective rate, motor nerve conduction velocity (MNCV), sensory nerve conduction velocity (SNCV), Toronto clinical scoring system (TCSS), and total symptom score (TSS). All statistical analyses will be performed using RevMan V.5.3 software. RESULTS: This review will evaluate the total effective rate, nerve conduction velocity, TCSS, TSS, and safety of ALA combined with epalrestat for patients with DPN, compare with epalrestat alone. CONCLUSION: Our study will provide evidence to assess whether epalrestat combined with ALA is an optional treatment for patients with DPN.
[Mh] Termos MeSH primário: Neuropatias Diabéticas/tratamento farmacológico
Metanálise como Assunto
Rodanina/análogos & derivados
Tiazolidinas
Ácido Tióctico
[Mh] Termos MeSH secundário: Antioxidantes/administração & dosagem
Antioxidantes/efeitos adversos
Quimioterapia Combinada
Inibidores Enzimáticos/administração & dosagem
Inibidores Enzimáticos/efeitos adversos
Seres Humanos
Ensaios Clínicos Controlados Aleatórios como Assunto
Projetos de Pesquisa
Rodanina/administração & dosagem
Rodanina/efeitos adversos
Tiazolidinas/administração & dosagem
Tiazolidinas/efeitos adversos
Ácido Tióctico/administração & dosagem
Ácido Tióctico/efeitos adversos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Enzyme Inhibitors); 0 (Thiazolidines); 424DV0807X (epalrestat); 73Y7P0K73Y (Thioctic Acid); 7O50LKL2G8 (Rhodanine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180209
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009828


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[PMID]:29341577
[Au] Autor:Biocanin V; Milic M; Vucetic M; Vasovic M; Zivadinovic D; Zivadinovic M; Cetkovic D; Calasan D; Brkovic B
[Ti] Título:Apical root-end filling with tricalcium silicate-based cement in a patient with diabetes mellitus: A case report.
[So] Source:Vojnosanit Pregl;73(12):1173-7, 2016 Dec.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Introduction: The material used for root-end filling has to be biocompatible with adjacent periapical tissue and to stimulate its regenerative processes. Tricalcium silicate cement (TSC), as a new dental material, shows good sealing properties with dentin, high compression strengths and better marginal adaptation than commonly used root-end filling materials. Although optimal postoperative healing of periapical tissues is mainly influenced by characteristics of end-root material used, it could sometimes be affected by the influence of systemic diseases, such as diabetes mellitus (DM). Case report: We presented apical healing of the upper central incisor, retrofilled with TSC, in a diabetic patient (type 2 DM) with peripheral neuropathy. Standard root-end resection of upper central incisor was accompanied by retropreparation using ultrasonic retrotips to the depth of 3 mm and retrofilling with TSC. Post-operatively, the surgical wound healed uneventfully. However, the patient reported undefined dull pain in the operated area that could possibly be attributed to undiagnosed intraoral diabetic peripheral neuropathy, what was evaluated clinically. Conclusion: Although TSC presents a suitable material for apical root-end filling in the treatment of chronic periradicular lesions a possible presence of systemic diseases, like type 2 DM, has to be considered in the treatment outcome estimation.
[Mh] Termos MeSH primário: Compostos de Cálcio/uso terapêutico
Diabetes Mellitus Tipo 2/complicações
Neuropatias Diabéticas/etiologia
Doenças Periapicais/cirurgia
Materiais Restauradores do Canal Radicular/uso terapêutico
Obturação do Canal Radicular
Silicatos/uso terapêutico
[Mh] Termos MeSH secundário: Diabetes Mellitus Tipo 2/diagnóstico
Diabetes Mellitus Tipo 2/fisiopatologia
Neuropatias Diabéticas/diagnóstico
Neuropatias Diabéticas/fisiopatologia
Seres Humanos
Masculino
Meia-Idade
Percepção da Dor
Limiar da Dor
Dor Pós-Operatória/complicações
Dor Pós-Operatória/fisiopatologia
Doenças Periapicais/complicações
Doenças Periapicais/diagnóstico por imagem
Radiografia Dentária
Obturação do Canal Radicular/efeitos adversos
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Calcium Compounds); 0 (Root Canal Filling Materials); 0 (Silicates); 404G39282C (tricalcium silicate)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150606137B


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[PMID]:29317209
[Au] Autor:Gong Y; Zhu Y; Zhu B; Si X; Heng D; Tang Y; Sun X; Lin L
[Ad] Endereço:Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
[Ti] Título:LncRNA MALAT1 is up-regulated in diabetic gastroparesis and involved in high-glucose-induced cellular processes in human gastric smooth muscle cells.
[So] Source:Biochem Biophys Res Commun;496(2):401-406, 2018 02 05.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recent years, widespread long non-coding RNAs (lncRNAs) were identified and known as regulator of gene expression. Diabetic gastroparesis (DGP) is one of the most common chronic complications of diabetes mellitus. There was no research reported the role of lncRNAs in DGP. In this study, we firstly established a rat model of DGP by STZ injection. Then, we detected the expression of MALAT1 and found that expression of MALAT1 was up-regulated in rat model of DGP, comparing to the control group (P < .01). Furthermore, we revealed that MALAT1 expression was increased in the samples from diabetic patients with DGP symptoms, in comparison with the control. In addition, we demonstrated that the inhibition of MALAT1 increased the expression of α-SMA and SM myosin heavy chains, reduced the cell viability, inhibited the potential of cell migration and induced cell apoptosis in human gastric smooth muscle cells (SMCs). Ultimately, we found that the regulation of MALAT1 expression modulated the function of high-glucose stimulation in human gastric SMCs. Therefore, our study firstly indicated that MALAT1 was up-regulated in DGP and played an important role in the pathogenesis of DGP.
[Mh] Termos MeSH primário: Diabetes Mellitus Experimental/genética
Neuropatias Diabéticas/genética
Gastroparesia/genética
Miócitos de Músculo Liso/metabolismo
RNA Longo não Codificante/genética
Estômago/metabolismo
[Mh] Termos MeSH secundário: Actinas/genética
Actinas/metabolismo
Animais
Apoptose/efeitos dos fármacos
Apoptose/genética
Movimento Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Diabetes Mellitus Experimental/induzido quimicamente
Diabetes Mellitus Experimental/complicações
Diabetes Mellitus Experimental/metabolismo
Neuropatias Diabéticas/induzido quimicamente
Neuropatias Diabéticas/complicações
Neuropatias Diabéticas/metabolismo
Esvaziamento Gástrico
Gastroparesia/induzido quimicamente
Gastroparesia/complicações
Gastroparesia/metabolismo
Regulação da Expressão Gênica
Glucose/farmacologia
Seres Humanos
Masculino
Miócitos de Músculo Liso/efeitos dos fármacos
Miócitos de Músculo Liso/patologia
Cadeias Pesadas de Miosina/genética
Cadeias Pesadas de Miosina/metabolismo
Cultura Primária de Células
RNA Longo não Codificante/metabolismo
Ratos
Ratos Sprague-Dawley
Transdução de Sinais
Estômago/efeitos dos fármacos
Estômago/patologia
Estreptozocina
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (ACTA2 protein, human); 0 (Actins); 0 (MALAT1 long non-coding RNA, human); 0 (RNA, Long Noncoding); 5W494URQ81 (Streptozocin); EC 3.6.4.1 (Myosin Heavy Chains); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE


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[PMID]:29304099
[Au] Autor:Li J; Zhang W; Wang X; Yuan T; Liu P; Wang T; Shen L; Huang Y; Li N; You H; Xiao T; Feng F; Ma C
[Ad] Endereço:Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, China.
[Ti] Título:Functional magnetic resonance imaging reveals differences in brain activation in response to thermal stimuli in diabetic patients with and without diabetic peripheral neuropathy.
[So] Source:PLoS One;13(1):e0190699, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Diabetes affects both the peripheral and central nervous systems. The aim of this study was to explore the changes in brain activity in response to thermal stimuli in diabetic patients with and without diabetic peripheral neuropathy (DPN) using functional magnetic resonance imaging (fMRI). METHODS: A total of 36 right-handed volunteers were enrolled: eight patients with Type-2 diabetes mellitus and DPN, 13 patients with Type-2 diabetes mellitus lacking DPN (NDPN patients), and 15 healthy volunteers (HV). Blood oxygenation level-dependent baseline scans were performed, first without any stimuli, and then with four sessions of thermal stimuli (0, 10, 34, and 44°C, in a random order) applied to the lateral side of the right lower extremity. There was a 240-s rest interval between each thermal stimulation. Each stimulation session consisted of three cycles of 30 s of stimulation followed by 30 s of rest. After each stimuli session, the participant rated pain and itch perception on a visual analog scale. The fMRI data series were analyzed by using Statistical Parametric Mapping 8 and Data Processing Assistant for Resting-State fMRI. RESULTS: In response to temperature stimuli, DPN patients showed stronger activation than HV and NDPN patients, not only in brain areas that participate in somatosensory pathways (right insula, left caudate nucleus, frontal gyrus, and cingulate cortex), but also in the cognition-related cerebral areas (right temporal lobe, left hippocampus, and left fusiform gyrus). Activation of vermis 1-3 was greater in NDPN patients than in HV in response to 0°C stimulation. CONCLUSIONS: fMRI may be useful for the early detection of central nervous system impairment caused by DPN. Our results indicate that central nervous system impairment related to diabetic neuropathy may not be limited to motion- and sensation-related cortical regions. Cognition-associated cerebral regions such as the hippocampus and fusiform gyrus are also affected by functional changes caused by DPN. This suggests that fMRI can detect the early stages of cognitive impairment in DPN patients before the symptoms become clinically significant.
[Mh] Termos MeSH primário: Encéfalo/fisiologia
Encéfalo/fisiopatologia
Neuropatias Diabéticas/diagnóstico por imagem
Neuropatias Diabéticas/fisiopatologia
Percepção/fisiologia
Sensação Térmica/fisiologia
[Mh] Termos MeSH secundário: Idoso
Encéfalo/diagnóstico por imagem
Mapeamento Encefálico
Temperatura Baixa
Diagnóstico Precoce
Feminino
Temperatura Alta
Seres Humanos
Extremidade Inferior/fisiologia
Extremidade Inferior/fisiopatologia
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Oxigênio/sangue
Dor/fisiopatologia
Estimulação Física
Prurido/fisiopatologia
Descanso
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
S88TT14065 (Oxygen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190699


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[PMID]:28467200
[Au] Autor:Santesson P; Lins PE; Kalani M; Adamson U; Lelic I; von Wendt G; Fagrell B; Jörneskog G
[Ad] Endereço:1 Microcirculatory Laboratory, Division of Medicine, Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden.
[Ti] Título:Skin microvascular function in patients with type 1 diabetes: An observational study from the onset of diabetes.
[So] Source:Diab Vasc Dis Res;14(3):191-199, 2017 May.
[Is] ISSN:1752-8984
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The development of disturbances in skin microcirculation in type 1 diabetes is not well characterised. We assessed skin microcirculation longitudinally from the onset of diabetes up to 29 years of duration to investigate when such disturbances start. MATERIAL AND METHODS: Seventeen adult patients with type 1 diabetes participated. Skin microvascular function in digit IV of the left hand was investigated by laser Doppler fluxmetry (LDF, arbitrary units [AU]). LDF was carried out at rest and following one-min arterial occlusion. Time to peak LDF (s) and percentage increase of LDF (post-occlusive reactive hyperaemia, PRH%) were determined. Retinopathy was assessed from fundus photographs or ophthalmoscopic recordings. RESULTS: Skin microvascular function remained normal during the first five years. Compared with baseline and a non-diabetic reference group, time to peak LDF was prolonged after 7-9 years of diabetes ( p < 0.01). PRH% was lower than in the reference group after 7-9 years ( p < 0.01), and lower than baseline after 24-29 years of diabetes ( p < 0.05). All but one patient developed retinopathy and the first signs were found after 10 years of diabetes. CONCLUSIONS: Functional disturbances in total skin microcirculation were observed after seven years in patients with type 1 diabetes and preceded diabetic complications such as retinopathy.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 1/complicações
Angiopatias Diabéticas/etiologia
Microcirculação
Microvasos/fisiopatologia
Pele/irrigação sanguínea
[Mh] Termos MeSH secundário: Adulto
Velocidade do Fluxo Sanguíneo
Estudos de Casos e Controles
Diabetes Mellitus Tipo 1/diagnóstico
Diabetes Mellitus Tipo 1/fisiopatologia
Angiopatias Diabéticas/diagnóstico
Angiopatias Diabéticas/fisiopatologia
Neuropatias Diabéticas/diagnóstico
Neuropatias Diabéticas/etiologia
Retinopatia Diabética/diagnóstico
Retinopatia Diabética/etiologia
Progressão da Doença
Feminino
Seres Humanos
Fluxometria por Laser-Doppler
Estudos Longitudinais
Masculino
Meia-Idade
Oftalmoscopia
Estudos Prospectivos
Fluxo Sanguíneo Regional
Fatores de Risco
Temperatura Cutânea
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1177/1479164117694463


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[PMID]:28459164
[Au] Autor:Nouman M; Leelasamran W; Chatpun S
[Ad] Endereço:1 Institute of Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
[Ti] Título:Effectiveness of Total Contact Orthosis for Plantar Pressure Redistribution in Neuropathic Diabetic Patients During Different Walking Activities.
[So] Source:Foot Ankle Int;38(8):901-908, 2017 Aug.
[Is] ISSN:1944-7876
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Using a total contact orthosis (TCO) is an effective method to offload in diabetic patients with foot neuropathy. However, the redistribution of peak plantar pressure is mostly observed during level walking, which may differ from other walking activities. The aim of this study was to investigate the plantar pressure from 4 regions of the foot during different walking activities (level walking, ramp ascending, ramp descending, stair ascending, and stair descending) in neuropathic diabetic patients with and without a TCO. METHODS: Sixteen neuropathic diabetic patients aged 40 to 60 years with calluses and hallux valgus were included in this study and were provided with TCOs made up of multifoam, Plastazote, and microcellular rubber. The plantar pressure and contact area with the TCO and without the TCO were recorded using the Pedar X system during different walking activities. RESULTS: A significant reduction of plantar pressure during different walking activities at the toes and forefoot regions was observed while walking with the TCO compared with walking without the TCO (control condition). Plantar pressure increased at the midfoot region when walking with the TCO, and no significant difference was observed at the hindfoot region between the control and TCO conditions. Furthermore, maximum contact area was observed during level walking with the TCO compared with other walking activities. CONCLUSION: The TCO significantly reduced and redistributed the peak plantar pressure from the sites where the ulceration rate is higher at the toes and forefoot compared with the other regions of the foot. LEVEL OF EVIDENCE: Therapeutic level II, lesser quality randomized controlled trial.
[Mh] Termos MeSH primário: Braquetes/normas
Pé Diabético/fisiopatologia
Neuropatias Diabéticas/fisiopatologia
/fisiologia
Antepé Humano/fisiopatologia
Hallux Valgus/fisiopatologia
Aparelhos Ortopédicos/normas
Dedos do Pé/fisiopatologia
Caminhada/fisiologia
[Mh] Termos MeSH secundário: Fenômenos Biomecânicos
Pé Diabético/terapia
Seres Humanos
Pressão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1177/1071100717704427


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[PMID]:28969623
[Au] Autor:Nasiry D; Khalatbary AR; Ahmadvand H; Talebpour Amiri F; Akbari E
[Ad] Endereço:Molecular and Cell Biology Research Center, Department of Anatomy, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
[Ti] Título:Protective effects of methanolic extract of Juglans regia L. leaf on streptozotocin-induced diabetic peripheral neuropathy in rats.
[So] Source:BMC Complement Altern Med;17(1):476, 2017 Oct 02.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Oxidative stress has a pivotal role in the pathogenesis and development of diabetic peripheral neuropathy (DPN), the most common and debilitating complications of diabetes mellitus. There is accumulating evidence that Juglans regia L. (GRL) leaf extract, a rich source of phenolic components, has hypoglycemic and antioxidative properties. This study aimed to determine the protective effects of Juglans regia L. leaf extract against streptozotocin-induced diabetic neuropathy in rat. METHODS: The DPN rat model was generated by intraperitoneal injection of a single 55 mg/kg dose of streptozotocin (STZ). A subset of the STZ-induced diabetic rats intragastically administered with GRL leaf extract (200 mg/kg/day) before or after the onset of neuropathy, whereas other diabetic rats received only isotonic saline as the same volume of GRL leaf extract. To evaluate the effects of GRL leaf extract on the diabetic neuropathy various parameters, including histopathology and immunohistochemistry of apoptotic and inflammatory factors were assessed along with nociceptive and biochemical assessments. RESULTS: Degeneration of the sciatic nerves which was detected in the STZ-diabetic rats attenuated after GRL leaf extract administration. Greater caspase-3, COX-2, and iNOS expression could be detected in the STZ-diabetic rats, which were significantly attenuated after GRL leaf extract administration. Also, attenuation of lipid peroxidation and nociceptive response along with improved antioxidant status in the sciatic nerve of diabetic rats were detected after GRL leaf extract administration. In other word, GRL leaf extract ameliorated the behavioral and structural indices of diabetic neuropathy even after the onset of neuropathy, in addition to blood sugar reduction. CONCLUSION: Our results suggest that GRL leaf extract exert preventive and curative effects against STZ-induced diabetic neuropathy in rats which might be due to its antioxidant, anti-inflammatory, and antiapoptotic properties. Protection against neuropathy.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Neuropatias Diabéticas/metabolismo
Juglans/química
Nervos Periféricos/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/química
Glicemia/efeitos dos fármacos
Peso Corporal/efeitos dos fármacos
Neuropatias Diabéticas/induzido quimicamente
Hipoglicemiantes/farmacologia
Masculino
Nervos Periféricos/patologia
Extratos Vegetais/química
Folhas de Planta/química
Ratos
Ratos Sprague-Dawley
Estreptozocina/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Blood Glucose); 0 (Hypoglycemic Agents); 0 (Plant Extracts); 5W494URQ81 (Streptozocin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1983-x


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[PMID]:28880907
[Au] Autor:Goel A; Shivaprasad C; Kolly A; Sarathi H A V; Atluri S
[Ad] Endereço:Department of Endocrinology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, Karnataka, India.
[Ti] Título:Comparison of electrochemical skin conductance and vibration perception threshold measurement in the detection of early diabetic neuropathy.
[So] Source:PLoS One;12(9):e0183973, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The early diagnosis of diabetic peripheral neuropathy (DPN) is challenging. Sudomotor dysfunction is one of the earliest detectable abnormalities in DPN. The present study aimed to determine the diagnostic performance of the electrochemical skin conductance (ESC) test in detecting early DPN, compared with the vibration perception threshold (VPT) test and diabetic neuropathy symptom (DNS) score, using the modified neuropathy disability score (NDS) as the reference standard. Five hundred and twenty-three patients with type 2 diabetes underwent an NDS-based clinical assessment for neuropathy. Participants were classified into the DPN and non-DPN groups based on the NDS (≥ 6). Both groups were evaluated further using the DNS, and VPT and ESC testing. A receiver-operator characteristic (ROC) curve analysis was performed to compare the efficacy of ESC measurements with those of DNS and VPT testing in detecting DPN. The DPN group (n = 110, 21%) had significantly higher HbA1c levels and longer diabetes durations compared with the non-DPN group (n = 413). The sensitivity of feet ESC < 60 µS, VPT testing, and DNS in detecting DPN were 85%, 72%, and 52%, respectively. The specificity of feet ESC, VPT, and DNS in detecting DPN were 85%, 90% and 60% respectively. The areas under the curves of the ROC plots for feet ESC, VPT testing, and DNS were 0.88, 0.84, and 0.6, respectively. A significant inverse linear relationship was noted between VPT and feet ESC (r = -0.45, p = <0.0001). The odds ratios for having DPN, based on the mean feet ESC testing < 60 µS, VPT testing > 15 V, and DNS ≥ 1, were 16.4, 10.9 and 1.8, respectively. ESC measurement is an objective and sensitive technique for the early detection of DPN. Feet ESC measurement was superior to VPT testing for identifying patients with early DPN.
[Mh] Termos MeSH primário: Neuropatias Diabéticas/diagnóstico
Neuropatias Diabéticas/fisiopatologia
Resposta Galvânica da Pele
Percepção
Limiar Sensorial
Vibração
[Mh] Termos MeSH secundário: Intervalos de Confiança
Feminino
Seres Humanos
Masculino
Meia-Idade
Razão de Chances
Curva ROC
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170908
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183973


  10 / 13110 MEDLINE  
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[PMID]:28859075
[Au] Autor:Fernando ME; Crowther RG; Lazzarini PA; Yogakanthi S; Sangla KS; Buttner P; Jones R; Golledge J
[Ad] Endereço:Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Australia.
[Ti] Título:Plantar pressures are elevated in people with longstanding diabetes-related foot ulcers during follow-up.
[So] Source:PLoS One;12(8):e0181916, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: High plantar pressures are implicated in the development of diabetes-related foot ulcers. Whether plantar pressures remain high in patients with chronic diabetes-related foot ulcers over time is uncertain. The primary aim of this study was to compare plantar pressures at baseline and three and six months later in participants with chronic diabetes-related foot ulcers (cases) to participants without foot ulcers (controls). METHODS: Standardised protocols were used to measure mean peak plantar pressure and pressure-time integral at 10 plantar foot sites (the hallux, toes, metatarsals 1 to 5, mid-foot, medial heel and lateral heel) during barefoot walking. Measurements were performed at three study visits: baseline, three and six months. Linear mixed effects random-intercept models were utilised to assess whether plantar pressures differed between cases and controls after adjusting for age, sex, body mass index, neuropathy status and follow-up time. Standardised mean differences (Cohen's d) were used to measure effect size. RESULTS: Twenty-one cases and 69 controls started the study and 16 cases and 63 controls completed the study. Cases had a higher mean peak plantar pressure at several foot sites including the toes (p = 0.005, Cohen's d = 0.36) and mid-foot (p = 0.01, d = 0.36) and a higher pressure-time integral at the hallux (p<0.001, d = 0.42), metatarsal 1 (p = 0.02, d = 0.33) and mid-foot (p = 0.04, d = 0.64) compared to controls throughout follow-up. A reduction in pressure-time integral at multiple plantar sites over time was detected in all participants (p<0.05, respectively). CONCLUSIONS: Plantar pressures assessed during gait are higher in diabetes patients with chronic foot ulcers than controls at several plantar sites throughout prolonged follow-up. Long term offloading is needed in diabetes patients with diabetes-related foot ulcers to facilitate ulcer healing.
[Mh] Termos MeSH primário: Complicações do Diabetes/fisiopatologia
Pé Diabético/fisiopatologia
Neuropatias Diabéticas/fisiopatologia
Úlcera do Pé/fisiopatologia
[Mh] Termos MeSH secundário: Idoso
Índice de Massa Corporal
Neuropatias Diabéticas/complicações
Feminino
Seguimentos
Marcha
Seres Humanos
Estudos Longitudinais
Masculino
Meia-Idade
Pressão
Caminhada
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181916



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