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  1 / 2999 MEDLINE  
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[PMID]:29381990
[Au] Autor:Zheng RW; Liu D; Eric TE; Ning YZ; Chen LL; Hu H; Ren Y
[Ad] Endereço:Department of Acupuncture and Moxibustion, Dongfang Hospital, The Second Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, China.
[Ti] Título:A case study of Ramsay Hunt Syndrome in conjunction with cranial polyneuritis.
[So] Source:Medicine (Baltimore);96(47):e8833, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Ramsay Hunt syndrome in conjunction with cranial polyneuritis is not extensively documented, and is very easily misdiagnosed. PATIENT CONCERNS: A case of a 53-year-old male with Ramsay Hunt syndrome in conjunction with cranial polyneuritis is presented with early symptoms of vertigo, cephalalgia, and facial palsy, followed by zoster oticus 10 days later. DIAGNOSES: Diagnosis was challenging as this condition presents with multiple neuropathies, and attempting to diagnose based on clinical symptoms was often misleading. Polymerase chain reaction can be used to test for presence of the virus in the cerebrospinal fluid, followed by targeted drug therapy. INTERVENTIONS: Acupuncture, in conjunction with fire cupping, bloodletting around the afflicted region on the face, as well as oral consumption of herbal medicine and vitamins for nerve nourishment was given to treat this disease. OUTCOMES: Due to misdiagnosis resulting in delayed treatment, peripheral facial paralysis was left as the main sequelae, while other symptoms responded quickly to treatment. After a 6-month follow-up, facial palsy was still present. LESSONS: Considering that targeted antiviral therapy can be used to increase the effectiveness of treatment, early diagnosis, and timely use of medication is critical.
[Mh] Termos MeSH primário: Doenças dos Nervos Cranianos/diagnóstico
Erros de Diagnóstico/efeitos adversos
Herpes Zoster da Orelha Externa/diagnóstico
Neurite (Inflamação)/diagnóstico
[Mh] Termos MeSH secundário: Antivirais/uso terapêutico
Doenças dos Nervos Cranianos/virologia
Paralisia Facial/diagnóstico
Paralisia Facial/virologia
Cefaleia/diagnóstico
Cefaleia/virologia
Herpes Zoster da Orelha Externa/virologia
Seres Humanos
Masculino
Meia-Idade
Neurite (Inflamação)/virologia
Vertigem/diagnóstico
Vertigem/virologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008833


  2 / 2999 MEDLINE  
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[PMID]:28651265
[Au] Autor:Örgel A; Hauser TK; Nägele T; Horger M
[Ti] Título:[Imaging in Cranial Nerve Neuritis by Lyme-Neuroborreliosis].
[Ti] Título:Neuritis bei Lyme-Neuroborreliose..
[So] Source:Rofo;189(7):599-602, 2017 07.
[Is] ISSN:1438-9010
[Cp] País de publicação:Germany
[La] Idioma:ger
[Mh] Termos MeSH primário: Borrelia
Doenças dos Nervos Cranianos/diagnóstico por imagem
Neuroborreliose de Lyme/diagnóstico por imagem
Imagem por Ressonância Magnética/métodos
Neurite (Inflamação)/diagnóstico por imagem
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Medicina Baseada em Evidências
Seres Humanos
Aumento da Imagem/métodos
Tomografia Computadorizada por Raios X/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE
[do] DOI:10.1055/s-0043-104535


  3 / 2999 MEDLINE  
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[PMID]:28542314
[Au] Autor:Portaro S; Naro A; Chillura A; Billeri L; Bramanti A; Bramanti P; Rodolico C; Calabrò RS
[Ad] Endereço:Istitute of Scientific Research and Care "IRCCS Centro Neurolesi Bonino-Pulejo", Messina, Italy.
[Ti] Título:Toward a more personalized motor function rehabilitation in Myotonic dystrophy type 1: The role of neuroplasticity.
[So] Source:PLoS One;12(5):e0178470, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Myotonic dystrophy type 1 (DM1) is the most prevalent adult muscular dystrophy, often accompanied by impairments in attention, memory, visuospatial and executive functions. Given that DM1 is a multi-system disorder, it requires a multi-disciplinary approach, including effective rehabilitation programs, focusing on the central nervous system neuroplasticity, in order to develop patient-tailored rehabilitative procedures for motor function recovery. Herein, we performed a transcranial magnetic stimulation (TMS) study aimed at investigating central motor conduction time, sensory-motor plasticity, and cortical excitability in 7 genetically defined DM1 patients. As compared to healthy individuals, DM1 patients showed a delayed central motor conduction time and an abnormal sensory-motor plasticity, with no alteration of cortical excitability. These findings may be useful to define patient-tailored motor rehabilitative programs.
[Mh] Termos MeSH primário: Distrofia Miotônica/fisiopatologia
Neurite (Inflamação)/fisiopatologia
Plasticidade Neuronal/fisiologia
Recuperação de Função Fisiológica/fisiologia
Córtex Sensório-Motor/fisiopatologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Sistema Nervoso Central/fisiopatologia
Eletromiografia/métodos
Feminino
Seres Humanos
Masculino
Memória/fisiologia
Meia-Idade
Estimulação Magnética Transcraniana/métodos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178470


  4 / 2999 MEDLINE  
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[PMID]:28017171
[Au] Autor:Yektas A; Çabalar M; Sar M; Alagöl A; Çelik DS; Yayla V; Tolga D
[Ad] Endereço:Bagcilar Training and Research Hospital, Istanbul, Turkey. Electronic address: akyektas722000@yahoo.co.uk.
[Ti] Título:Perineural dexmedetomidine effects on sciatic nerve in rat.
[So] Source:Braz J Anesthesiol;67(1):57-66, 2017 Jan - Feb.
[Is] ISSN:0104-0014
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The present study was designed to test the hypothesis that high dose dexmedetomidine would increase the duration of antinociception to a thermal stimulus in a rat model of sciatic nerve blockade without causing nerve damage. The rats were anesthetized with isoflurane. After electromyography (EMG) recordings, right sciatic nerves were explored and perineural injections were delivered: Group D (n=7), 40µgµgkg dexmedetomidine administration, Group II (n=6), (0.2mL) saline administration, Group III (n=2), only surgically exploration of the right sciatic nevre. Time to paw withdrawal latency (PAW) to a thermal stimulus for both paws and an assessment of motor function were measured every 30min after the nerve block until a return to baseline. The compound muscle action potential (CMAP) of right and left sciatic nerves were recorded 10 times per each nerve once more after perineural injections at 14 day. After EMG recordings, right and the part of left sciatic nerve were excised at a length of at minimum 15mm for histopathological examination. Comparison of right/left CMAP amplitude ratios before and 14 days after the procedure showed a statistically significant difference (p=0.000). There were no differences in perineural inflammation between the Group D, Group S, and Group E at 14 days.
[Mh] Termos MeSH primário: Analgésicos não Entorpecentes/farmacologia
Dexmedetomidina/farmacologia
Nervo Isquiático/efeitos dos fármacos
[Mh] Termos MeSH secundário: Análise de Variância
Animais
Estimulação Elétrica
Eletromiografia
Extremidade Inferior
Masculino
Bloqueio Nervoso/métodos
Neurite (Inflamação)/induzido quimicamente
Ratos Sprague-Dawley
Tempo de Reação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Non-Narcotic); 67VB76HONO (Dexmedetomidine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161227
[St] Status:MEDLINE


  5 / 2999 MEDLINE  
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[PMID]:27986526
[Au] Autor:Maldonado AA; Amrami KK; Mauermann ML; Spinner RJ
[Ad] Endereço:Mayo Clinic, Department of Neurologic Surgery, 200 1st Street South West, Rochester, MN 55905, USA.
[Ti] Título:Nontraumatic "isolated" posterior interosseous nerve palsy: Reinterpretation of electrodiagnostic studies and MRIs.
[So] Source:J Plast Reconstr Aesthet Surg;70(2):159-165, 2017 Feb.
[Is] ISSN:1878-0539
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Different hypotheses have been proposed for the pathophysiology of posterior interosseous nerve (PIN) palsy, namely compression, nerve inflammation, and fascicular constriction. We hypothesized that critical reinterpretation of electrodiagnostic (EDX) studies and MRIs of patients with a diagnosis of PIN palsy could provide insight into the pathophysiology and treatment. MATERIALS AND METHODS: We retrospectively reviewed patients with a diagnosis of nontraumatic PIN palsy and an upper extremity EDX and MRI. The original EDX studies and MRIs were reinterpreted by a neuromuscular neurologist and musculoskeletal radiologist, respectively, both blinded to our hypothesis. RESULTS: Fifteen patients met the inclusion criteria, i.e., having an "isolated" PIN palsy. Four patients (27%) had a defined mass compressing the PIN. The remaining 11 patients (73%) presented with at least one finding incompatible with the compression hypothesis: physical examination revealed that weakness in muscles was not innervated by the PIN in 4 patients (36%); EDX abnormalities not related to the PIN were found in 4 patients (36%); and reinterpretation of the MRIs showed muscle atrophy or nerve enlargement beyond the territory of the PIN in 9 patients (82%), without any evidence of compression of the PIN in the proximal forearm. CONCLUSION: The eleven patients in our series with presumed isolated and idiopathic PIN palsy had evidence of a more diffuse nerve-muscle involvement pattern, without any radiologic signs of nerve compression of the PIN itself. These data would favor an inflammatory pathophysiology when a structural lesion compressing the nerve is ruled out with imaging.
[Mh] Termos MeSH primário: Eletrodiagnóstico/métodos
Antebraço/inervação
Previsões
Imagem por Ressonância Magnética/métodos
Neurite (Inflamação)/complicações
Paralisia/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Neurite (Inflamação)/diagnóstico
Neurite (Inflamação)/fisiopatologia
Paralisia/etiologia
Paralisia/fisiopatologia
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161218
[St] Status:MEDLINE


  6 / 2999 MEDLINE  
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[PMID]:27956101
[Au] Autor:Takano K; Yamamoto M; Takahashi H; Himi T
[Ad] Endereço:Department of Otolaryngology, Sapporo Medical University School of Medicine, S1W16, Chuo-ku, Sapporo 060-8543, Japan. Electronic address: kent@sapmed.ac.jp.
[Ti] Título:Recent advances in knowledge regarding the head and neck manifestations of IgG4-related disease.
[So] Source:Auris Nasus Larynx;44(1):7-17, 2017 Feb.
[Is] ISSN:1879-1476
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:IgG4-related disease (IgG4-RD) is a chronic inflammatory disorder, characterized by elevated serum IgG4 levels as well as abundant infiltration of IgG4-positive plasmacytes and fibrosis in various organs, including the head and neck region. In particular, the salivary glands, orbit, and thyroid are common sites of disease involvement. IgG4-RD is diagnosed based on various clinical, serological, and histopathological findings, none of which are pathognomonic. Hence, various differential diagnoses, which exhibit elevated serum IgG4 levels and infiltration of IgG4-postive cells into tissues, need to be excluded, especially malignant diseases and mimicking disorders. Systemic corticosteroids are generally effective in inducing IgG4-RD remission; however, recurrent or refractory cases are common. In addition, although the pathogenic mechanisms of IgG4-RD remain unclear, an antigen-driven inflammatory condition is believed to be involved. Recent studies have indicated the important pathogenic role of B cell/T cell collaboration and innate immunity in this disease. Nevertheless, additional research and discussions are needed to resolve many remaining questions. In this review, we provide an overview of the recent insights on the history, clinical features, diagnosis, and treatment of IgG4-RD in the head and neck region. Furthermore, we have also addressed the pathogenesis of this disease.
[Mh] Termos MeSH primário: Doenças Autoimunes/imunologia
Dacriocistite/imunologia
Imunoglobulina G/imunologia
Rinite/imunologia
Sialadenite/imunologia
Sinusite/imunologia
Tireoidite Autoimune/imunologia
[Mh] Termos MeSH secundário: Corticosteroides/uso terapêutico
Doenças Autoimunes/tratamento farmacológico
Hipofisite Autoimune/tratamento farmacológico
Hipofisite Autoimune/imunologia
Dacriocistite/tratamento farmacológico
Seres Humanos
Linfadenite/tratamento farmacológico
Linfadenite/imunologia
Mastoidite/tratamento farmacológico
Mastoidite/imunologia
Neurite (Inflamação)/tratamento farmacológico
Neurite (Inflamação)/imunologia
Otite/tratamento farmacológico
Otite/imunologia
Rinite/tratamento farmacológico
Sialadenite/tratamento farmacológico
Sinusite/tratamento farmacológico
Tireoidite Autoimune/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Immunoglobulin G)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170723
[Lr] Data última revisão:
170723
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161214
[St] Status:MEDLINE


  7 / 2999 MEDLINE  
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[PMID]:27862491
[Au] Autor:Gougeon ML
[Ad] Endereço:Institut Pasteur, Antiviral Immunity, Biotherapy and Vaccine Unit, Infection and Epidemiology Department, Paris, France.
[Ti] Título:Alarmins and central nervous system inflammation in HIV-associated neurological disorders.
[So] Source:J Intern Med;281(5):433-447, 2017 May.
[Is] ISSN:1365-2796
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In the era of highly active antiretroviral therapy (HAART), HIV-1-associated neurocognitive disorders (HAND) persist in infected individuals with adequate immunological and virological status. Risk factors for cognitive impairment include hepatitis C virus co-infection, host genetic factors predisposing to HAND, the early establishment of the virus in the CNS and its persistence under HAART; thus, the CNS is an important reservoir for HIV. Microglial cells are permissive to HIV-1, and NLRP3 inflammasome-associated genes were found expressed in brains of HIV-1-infected persons, contributing to brain disease. Inflammasomes can be triggered by alarmins or danger-associated molecular patterns (DAMPs), which directly stimulate the production of proinflammatory mediators by glial cells, contribute to blood-brain barrier injury through induction of release of various proteases and allow the passage of infected macrophages, and trigger IL-1ß release from primed cells. Amongst alarmins involved in HIV-1-induced neuropathogenesis, IL-33 and high-mobility group box 1 (HMGB1) are of particular interest. Neurocognitive alterations were recently associated with dysregulation of the IL-33/ST2 axis in the CNS, leading to the induction of neuronal apoptosis, decrease in synaptic function and neuroinflammation. Specific biomarkers, including HMGB1 and anti-HMGB1 antibodies, have been identified in cerebrospinal fluid from patients with HAND, correlated with immune activation and identifying a very early stage of neurocognitive impairment that precedes changes in metabolites detected by magnetic resonance spectroscopy. Moreover, HMGB1 plays a crucial role in HIV-1 persistence in dendritic cells and in the constitution of viral reservoirs. In this review, the mechanisms whereby alarmins contribute to HIV-1-induced CNS inflammation and neuropathogenesis will be discussed.
[Mh] Termos MeSH primário: Alarminas/fisiologia
Doenças do Sistema Nervoso Central/virologia
Infecções por HIV/etiologia
HIV-1
Neurite (Inflamação)/virologia
[Mh] Termos MeSH secundário: Fármacos Anti-HIV/uso terapêutico
Biomarcadores/metabolismo
Doenças do Sistema Nervoso Central/imunologia
Doença Crônica
Reservatórios de Doenças
Proteína gp120 do Envelope de HIV/fisiologia
Infecções por HIV/tratamento farmacológico
Infecções por HIV/imunologia
Proteína HMGB1/fisiologia
Seres Humanos
Imunidade Inata/imunologia
Inflamassomos/fisiologia
Interleucina-33/fisiologia
Neurite (Inflamação)/imunologia
Doenças Neurodegenerativas/imunologia
Doenças Neurodegenerativas/virologia
Produtos do Gene tat do Vírus da Imunodeficiência Humana/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Alarmins); 0 (Anti-HIV Agents); 0 (Biomarkers); 0 (HIV Envelope Protein gp120); 0 (HMGB1 Protein); 0 (HMGB1 protein, human); 0 (Inflammasomes); 0 (Interleukin-33); 0 (tat Gene Products, Human Immunodeficiency Virus)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE
[do] DOI:10.1111/joim.12570


  8 / 2999 MEDLINE  
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[PMID]:27859670
[Au] Autor:Mowla MR; Ara S; Mizanur Rahman AFM; Tripura SP; Paul S
[Ad] Endereço:Department of Dermatology & Venereology, Chittagong Medical College, Chittagong, Bangladesh.
[Ti] Título:Leprosy reactions in postelimination stage: the Bangladesh experience.
[So] Source:J Eur Acad Dermatol Venereol;31(4):705-711, 2017 Apr.
[Is] ISSN:1468-3083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Leprosy reactions are immunologically mediated conditions and a major cause of disability before, during and after multidrug therapy (MDT). Little data have been published on the epidemiology of leprosy reactions in Bangladesh. OBJECTIVES: To describe the pattern and prevalence of leprosy reactions in the postelimination stage. METHODS: A descriptive retrospective cross-sectional study was carried out in Chittagong Medical College Hospital using the registered records of patients in the period between 2004 and 2013. RESULTS: Of the 670 patients with leprosy, 488 (73.38%) were males and 182 (27.37%) were females. The prevalence of reaction was in 300 (44.78%) patients with a male:female ratio of 3.55 : 1. The age-specific cumulative reaction cases at >40 years were 115 (38.33%) among all age groups. The prevalence of reaction was found to be in 166 (55.33%) patients for the reversal reaction, 49 (16.57%) for the erythema nodosum leprosum (ENL) and 85 (28.33%) for the neuritis. Borderline tuberculoid was most common (106, 35.33%)in the reversal reaction group, while lepromatous leprosy was most common (37, 12.33%) in ENL group. More than half of the patients (169, 56.33%) had reactions at the time of presentations, while 85 (28.33%) and 46 (15.33%) patients developed reaction during and after MDT, respectively. The reversal reaction group presented with ≥six skin lesions in 96 (57.83%) patients and ≥two nerve function impairments (NFIs) in 107 (64.46%) patients. The ENL was present chiefly as papulo-nodular lesions in 45 (91.84%) patients followed by pustule-necrotic lesions in four (8.16%), neuritis in 33 (67.35%), fever in 24 (48.98%), lymphadenitis in six (12.24%), arthritis in five (10.20%) and iritis in two (4.08%). Bacterial index ≥3 had been demonstrated in 34 (60.71%) patients in ENL group. CONCLUSION: The incidence of leprosy reaction seemed to be more than three times common in borderline tuberculoid (52.33%) group than in lepromatous leprosy (14%) group. Reactions with NFI and disability still occur among multibacillary patients during and after MDT. Early detection and management of leprosy reaction are very important in preventing disability and deformity, and patients should be educated to undergo regular follow-up examinations. Developing reinforced new therapies to curb leprosy reactions is crucial for improving leprosy healthcare services.
[Mh] Termos MeSH primário: Eritema Nodoso/imunologia
Hipersensibilidade Tardia/complicações
Hipersensibilidade Tardia/epidemiologia
Hanseníase/tratamento farmacológico
Linfadenite/imunologia
Neurite (Inflamação)/imunologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Antígenos de Bactérias/imunologia
Artrite/epidemiologia
Artrite/imunologia
Bangladesh/epidemiologia
Criança
Pré-Escolar
Eritema Nodoso/epidemiologia
Feminino
Seres Humanos
Lactente
Irite/epidemiologia
Irite/imunologia
Hansenostáticos/uso terapêutico
Hanseníase Dimorfa/tratamento farmacológico
Hanseníase Virchowiana/tratamento farmacológico
Hanseníase Tuberculoide/tratamento farmacológico
Linfadenite/epidemiologia
Masculino
Neurite (Inflamação)/epidemiologia
Prevalência
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Bacterial); 0 (Leprostatic Agents)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE
[do] DOI:10.1111/jdv.14049


  9 / 2999 MEDLINE  
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[PMID]:27550711
[Au] Autor:Narang T; Arshdeep; Dogra S
[Ad] Endereço:Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
[Ti] Título:Minocycline in leprosy patients with recent onset clinical nerve function impairment.
[So] Source:Dermatol Ther;30(1), 2017 Jan.
[Is] ISSN:1529-8019
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nerve function impairment (NFI) in leprosy may occur and progress despite multidrug therapy alone or in combination with corticosteroids. We observed improvement in neuritis when minocycline was administered in patients with type 2 lepra reaction. This prompted us to investigate the role of minocycline in recent onset NFI, especially in corticosteroid unresponsive leprosy patients. Leprosy patients with recent onset clinical NFI (<6 months), as determined by Monofilament Test (MFT) and Voluntary Muscle Test (VMT), were recruited. Minocycline 100mg/day was given for 3 months to these patients. The primary outcome was the proportion of patients with 'restored,' 'improved,' 'stabilized,' or 'deteriorated' NFI. Secondary outcomes included any improvement in nerve tenderness and pain. In this pilot study, 11 patients were recruited. The progression of NFI was halted in all; with 9 out of 11 patients (81.82%) showing ?restored? or ?improved? sensory or motor nerve functions, on assessment with MFT and VMT. No serious adverse effects due to minocycline were observed. Our pilot study demonstrates the efficacy and safety of minocycline in recent onset NFI in leprosy patients. However, larger and long term comparative trials are needed to validate the efficacy of minocycline in leprosy neuropathy.
[Mh] Termos MeSH primário: Hansenostáticos/uso terapêutico
Hanseníase/tratamento farmacológico
Minociclina/uso terapêutico
Neurite (Inflamação)/tratamento farmacológico
Doenças do Sistema Nervoso Periférico/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Hansenostáticos/efeitos adversos
Hanseníase/diagnóstico
Hanseníase/microbiologia
Masculino
Meia-Idade
Minociclina/efeitos adversos
Atividade Motora/efeitos dos fármacos
Neurônios Motores/efeitos dos fármacos
Neurônios Motores/microbiologia
Neurite (Inflamação)/diagnóstico
Neurite (Inflamação)/microbiologia
Neurite (Inflamação)/fisiopatologia
Exame Neurológico
Doenças do Sistema Nervoso Periférico/diagnóstico
Doenças do Sistema Nervoso Periférico/microbiologia
Doenças do Sistema Nervoso Periférico/fisiopatologia
Projetos Piloto
Recuperação de Função Fisiológica
Limiar Sensorial/efeitos dos fármacos
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Leprostatic Agents); FYY3R43WGO (Minocycline)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160824
[St] Status:MEDLINE
[do] DOI:10.1111/dth.12404


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[PMID]:27277137
[Au] Autor:La Rocca V; da Fonsêca DV; Silva-Alves KS; Ferreira-da-Silva FW; de Sousa DP; Santos PL; Quintans-Júnior LJ; Leal-Cardoso JH; de Almeida RN
[Ad] Endereço:Postgraduate Program in Biotechnology (Renorbio), Federal University of Paraíba, João Pessoa, Brazil.
[Ti] Título:Geraniol Induces Antinociceptive Effect in Mice Evaluated in Behavioural and Electrophysiological Models.
[So] Source:Basic Clin Pharmacol Toxicol;120(1):22-29, 2017 Jan.
[Is] ISSN:1742-7843
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Geraniol (GER) is a monoterpene alcohol with various biochemical and pharmacological properties present in the essential oil of more than 160 species of herbs (especially the Cymbopogon genus). In this study, we evaluated the antinociceptive activity of GER in behavioural and electrophysiological in vitro experimental models of nociception using male Swiss mice. GER (12.5, 25 or 50 mg/kg i.p. and 50 or 200 mg/kg p.o.) reduced the number of writhes induced by acetic acid. The opioid antagonist naloxone (5 mg/kg s.c.) administered in mice subsequently treated with GER (25 mg/kg i.p.) did not reverse such antinociceptive activity, suggesting a non-opioid pathway for the mechanism of action. GER (12.5, 25 and 50 mg/kg i.p.) reduced paw licking time in the second phase of the formalin test. Also, in the glutamate test, GER when administered 50 mg/kg i.p. reduced paw licking time, probably modulating glutamatergic neurotransmission. GER blocked reversibly components of the compound action potential (CAP) recorded in isolated sciatic nerve in a concentration- and drug exposure time-dependent manner: 1 mM to 120 min. for the first component and 0.6 mM to 90 min. for the second component. The IC was calculated for the peak-to-peak amplitude (PPA) at 0.48 ± 0.04 mM. The conduction velocity was also reduced by exposure to GER starting from the concentration of 0.3 mM for both components of the CAP. In conclusion, it is suggested that GER has antinociceptive activity, especially in pain related to inflammation, and in part related to reduced peripheral nerve excitability.
[Mh] Termos MeSH primário: Analgésicos/uso terapêutico
Modelos Animais de Doenças
Modelos Neurológicos
Neurite (Inflamação)/tratamento farmacológico
Neurônios/efeitos dos fármacos
Nervo Isquiático/efeitos dos fármacos
Terpenos/uso terapêutico
[Mh] Termos MeSH secundário: Potenciais de Ação/efeitos dos fármacos
Administração Oral
Analgésicos/administração & dosagem
Analgésicos/farmacologia
Animais
Comportamento Animal/efeitos dos fármacos
Relação Dose-Resposta a Droga
Fenômenos Eletrofisiológicos/efeitos dos fármacos
Técnicas In Vitro
Injeções Intraperitoneais
Cinética
Masculino
Camundongos
Condução Nervosa/efeitos dos fármacos
Neurite (Inflamação)/imunologia
Neurônios/imunologia
Nervo Isquiático/fisiologia
Transmissão Sináptica/efeitos dos fármacos
Terpenos/administração & dosagem
Terpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Terpenes); L837108USY (geraniol)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160610
[St] Status:MEDLINE
[do] DOI:10.1111/bcpt.12630



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