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[PMID]:29390370
[Au] Autor:Chen JH; Lee KY; Hu CJ; Chung CC
[Ad] Endereço:Department of Neurology.
[Ti] Título:Coexisting myasthenia gravis, myositis, and polyneuropathy induced by ipilimumab and nivolumab in a patient with non-small-cell lung cancer: A case report and literature review.
[So] Source:Medicine (Baltimore);96(50):e9262, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Immune checkpoint inhibitors have led to the development of new approaches for cancer treatment with positive outcomes. However, checkpoint blockade is associated with a unique spectrum of immune-related adverse events (irAEs), which may cause irreversible neurological deficits and even death. PATIENT CONCERNS: We presented a case of a 57-year-old man with non-small-cell lung cancer.who developed ptosis, dyspnea, and muscle weakness as initial symptoms with progression after the treatment with ipilimumab and nivolumab. DIAGNOSES: Myasthenia gravis was confirmed by serum acetylcholine receptor antibody and single fiber electromyography. Myositis was identified by high level of serum creatine phosphokinase and electromyography. Polyneuropathy was identified by nerve conduction study. INTERVENTIONS: The patient underwent treatment with steroid and pyridostigmine. Respiratory rehabilitation was also performed. OUTCOMES: Dyspnea and muscle weakness improved gradually. Ipilimumab and nivolumab were permanently discontinued. LESSONS: This case has increased the clinical awareness by indicating that the checkpoint inhibitors-related neurological irAEs could be complicated and simultaneously involve multiple neurological systems. Early recognition and complete evaluation are critical in clinical practice.
[Mh] Termos MeSH primário: Anticorpos Monoclonais/efeitos adversos
Antineoplásicos Imunológicos/efeitos adversos
Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico
Ipilimumab/efeitos adversos
Neoplasias Pulmonares/tratamento farmacológico
Miastenia Gravis/induzido quimicamente
Miosite/induzido quimicamente
Polineuropatias/induzido quimicamente
[Mh] Termos MeSH secundário: Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Antineoplastic Agents, Immunological); 0 (Ipilimumab); 31YO63LBSN (nivolumab)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009262


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[PMID]:28454586
[Au] Autor:Pan JH; Peng CY; Lo CT; Dai CY; Wang CL; Chuang HY
[Ad] Endereço:Department of Occupational & Environmental Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. euphyflower1227@gmail.com.
[Ti] Título:n-Hexane intoxication in a Chinese medicine pharmaceutical plant: a case report.
[So] Source:J Med Case Rep;11(1):120, 2017 Apr 28.
[Is] ISSN:1752-1947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: n-Hexane is a well-known neurotoxicant. Polyneuropathy due to occupational n-hexane exposure has been reported worldwide, however, our case is the first report in the Chinese herb industry. CASE PRESENTATION: A 25-year-old Asian man experienced progressive weakness and numbness in his hands and feet after working as an operator in a Chinese medicine pharmaceutical plant for the manufacture of Chinese herbal pain relief patches for 10 months. Electrophysiological studies indicated a reduction in nerve conduction velocity, prolongation of distal latencies, mildly positive sharp waves, and reduced recruitment with polyphasic potentials, particularly at distal sites. Demyelination with axonal degeneration caused by occupational n-hexane exposure was strongly suspected. Through investigation of our patient's workplace, the ambient n-hexane concentration in air was found to considerably exceed the permissible exposure limit/time-weighted average for n-hexane in Taiwan. His symptoms were gradually relieved after 4 months of cessation of exposure to n-hexane. He was then confirmed as a case of occupational n-hexane intoxication. Further effective control measures should be implemented as soon as possible to prevent exposure of workers to n-hexane. CONCLUSIONS: Despite a typical clinical presentation, his exposure at workplace was appropriately investigated. Chemical exposure in Chinese medicine pharmaceutical plants could be an emerging issue that may affect workers' health. The lack of knowledge and management of solvents could endanger the health of workers. This case has profound educational implications for occupational health and is worthy of further follow-up for improving hazards control.
[Mh] Termos MeSH primário: Grupo com Ancestrais do Continente Asiático
Medicamentos de Ervas Chinesas/química
Hexanos/envenenamento
Doenças Profissionais/induzido quimicamente
Exposição Ocupacional/efeitos adversos
Polineuropatias/induzido quimicamente
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Masculino
Doenças Profissionais/fisiopatologia
Plantas Medicinais/química
Polineuropatias/fisiopatologia
Recuperação de Função Fisiológica
Taiwan
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Hexanes); 2DDG612ED8 (n-hexane)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1186/s13256-017-1280-9


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[PMID]:28837908
[Au] Autor:Garg N; Howells J; Yiannikas C; Vucic S; Krishnan AV; Spies J; Bostock H; Mathey EK; Pollard JD; Park SB; Kiernan MC
[Ad] Endereço:Brain and Mind Centre, Sydney Medical School, The University of Sydney, 94 Mallett St, Camperdown, NSW 2050, Australia; Department of Neurology, Royal Prince Alfred Hospital, The University of Sydney, NSW, Australia. Electronic address: nidhi.garg@sydney.edu.au.
[Ti] Título:Motor unit remodelling in multifocal motor neuropathy: The importance of axonal loss.
[So] Source:Clin Neurophysiol;128(10):2022-2028, 2017 Oct.
[Is] ISSN:1872-8952
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To estimate the degree of axonal loss in patients diagnosed with multifocal motor neuropathy (MMN) using a novel assessment of motor unit numbers and size. METHODS: Automated motor unit number estimation using a compound muscle action potential (CMAP) scan was undertaken in median nerves with conduction block. Results were compared with 30 age-matched healthy controls. RESULTS: Compared with healthy controls, MMN patients had fewer motor units (MMN: 33±11vs HC: 93±36 [mean±SD]; p<0.0001) and larger 'size of the largest unit' (MMN: 1.2±0.5mVvs HC: 0.4±0.1mV; p<0.0001), despite having normal distal CMAP amplitudes (MMN: 7.6±1.8mVvs HC: 8.7±2.5mV; p=0.24). CONCLUSIONS: MMN is associated with marked axonal loss which may be masked by striking re-innervation resulting in preservation of distal CMAP amplitudes. SIGNIFICANCE: Assessment of motor unit properties should be incorporated into assessment of disease progression in MMN, given that nerve conduction studies are insensitive to motor unit remodelling.
[Mh] Termos MeSH primário: Axônios/fisiologia
Doença dos Neurônios Motores/fisiopatologia
Degeneração Neural/fisiopatologia
Polineuropatias/fisiopatologia
Recrutamento Neurofisiológico/fisiologia
[Mh] Termos MeSH secundário: Potenciais de Ação/fisiologia
Adulto
Idoso
Estudos de Coortes
Feminino
Seres Humanos
Masculino
Meia-Idade
Doença dos Neurônios Motores/diagnóstico
Degeneração Neural/diagnóstico
Condução Nervosa/fisiologia
Polineuropatias/diagnóstico
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170825
[St] Status:MEDLINE


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[PMID]:28837658
[Au] Autor:Apostolidis L; Schwarz D; Xia A; Weiler M; Heckel A; Godel T; Heiland S; Schlemmer HP; Jäger D; Bendszus M; Bäumer P
[Ad] Endereço:Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg, Germany.
[Ti] Título:Dorsal root ganglia hypertrophy as in vivo correlate of oxaliplatin-induced polyneuropathy.
[So] Source:PLoS One;12(8):e0183845, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To investigate in vivo morphological and functional correlates of oxaliplatin-induced peripheral neuropathy (OXA-PNP) by magnetic resonance neurography (MRN). METHODS: Twenty patients (7 female, 13 male, 58.9±10.0 years) with mild to moderate OXA-PNP and 20 matched controls (8 female, 12 male, 55.7±15.6 years) were prospectively enrolled. All patients underwent a detailed neurophysiological examination prior to neuroimaging. A standardized imaging protocol at 3.0 Tesla included the lumbosacral plexus and both sciatic nerves and their branches using T2-weighted fat-saturated sequences and diffusion tensor imaging. Quantitative assessment included volumetry of the dorsal root ganglia (DRG), sciatic nerve normalized T2 (nT2) signal and caliber, and fractional anisotropy (FA), mean diffusivity (MD), axial (AD) and radial diffusivity (RD). Additional qualitative evaluation of sciatic, peroneal, and tibial nerves evaluated the presence, degree, and distribution of nerve lesions. RESULTS: DRG hypertrophy in OXA-PNP patients (207.3±47.7mm3 vs. 153.0±47.1mm3 in controls, p = 0.001) was found as significant morphological correlate of the sensory neuronopathy. In contrast, peripheral nerves only exhibited minor morphological alterations qualitatively. Quantitatively, sciatic nerve caliber (27.3±6.7mm2 vs. 27.4±7.4mm2, p = 0.80) and nT2 signal were not significantly changed in patients (1.32±0.22 vs. 1.22±0.26, p = 0.16). AD, RD, and MD showed a non-significant decrease in patients, while FA was unchanged. CONCLUSION: OXA-PNP manifests with morphological and functional correlates that can be detected in vivo by MRN. We report hypertrophy of the DRG that stands in contrast to experimental and postmortem studies. DRG volume should be further investigated as a biomarker in other sensory peripheral neuropathies and ganglionopathies.
[Mh] Termos MeSH primário: Gânglios Espinais/efeitos dos fármacos
Compostos Organoplatínicos/toxicidade
Polineuropatias/induzido quimicamente
[Mh] Termos MeSH secundário: Idoso
Imagem de Tensor de Difusão
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Polineuropatias/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organoplatinum Compounds); 04ZR38536J (oxaliplatin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170825
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183845


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[PMID]:28710923
[Au] Autor:Kural MA; Karlsson P; Pugdahl K; Isak B; Fuglsang-Frederiksen A; Tankisi H
[Ad] Endereço:Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark.
[Ti] Título:Diagnostic utility of distal nerve conduction studies and sural near-nerve needle recording in polyneuropathy.
[So] Source:Clin Neurophysiol;128(9):1590-1595, 2017 Sep.
[Is] ISSN:1872-8952
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The electrodiagnosis of polyneuropathy (PNP) may benefit from examination using near-nerve needle technique (NNT) and from inclusion of distal nerves. This study compared the diagnostic utility of distal nerve conduction studies (NCS) and NNT recording. METHODS: Bilateral NNT and surface recording of the sural nerve and surface recording of the dorsal sural and medial plantar nerves were prospectively done in 91 patients with clinically suspected PNP. Distal NCS were additionally done in 37 healthy controls. Diagnostic reference standard was the final clinical diagnosis retrieved from the patients medical records after 1-4years. RESULTS: The clinical follow-up diagnosis confirmed PNP in 68 patients. Equally high sensitivities of the dorsal sural (72%), medial plantar (75%), and sural nerve with NNT recording (77%) were seen, while the sensitivity of conventional surface recording of the sural nerve was lower (60%). Sural NCS with both NNT and surface recording and dorsal sural NCS showed high specificities (85-95%) and positive predictive values (94-98%), while a lower specificity was seen for the medial plantar nerve (68%). CONCLUSION: NCS of distal nerves, especially the dorsal sural nerve, have high diagnostic power equalling sural NNT recording. SIGNIFICANCE: The electrodiagnostic evaluation of patients with suspected PNP benefits from NCS of distal nerves.
[Mh] Termos MeSH primário: Agulhas
Condução Nervosa/fisiologia
Polineuropatias/diagnóstico
Polineuropatias/fisiopatologia
Nervo Sural/fisiopatologia
Nervo Tibial/fisiopatologia
[Mh] Termos MeSH secundário: Potenciais de Ação/fisiologia
Adulto
Idoso
Eletrodiagnóstico/instrumentação
Eletrodiagnóstico/métodos
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170716
[St] Status:MEDLINE


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[PMID]:28682981
[Au] Autor:Wintermann GB; Rosendahl J; Weidner K; Strauß B; Petrowski K
[Ad] Endereço:*Department of Psychotherapy and Psychosomatic Medicine, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden; †Center for Sepsis Control and Care, and ‡Institute of Psychosocial Medicine and Psychotherapy, Jena University Hospital, Friedrich-Schiller University, Jena; and §Department of Workplace Health Promotion, German Sport University Cologne, Cologne, Germany.
[Ti] Título:Risk Factors of Delayed Onset Posttraumatic Stress Disorder in Chronically Critically Ill Patients.
[So] Source:J Nerv Ment Dis;205(10):780-787, 2017 Oct.
[Is] ISSN:1539-736X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The main aim of this study was to investigate factors associated with a delayed-onset posttraumatic stress disorder (PTSD) after the intensive care unit (ICU) treatment of patients with a chronic critical illness (CCI). Patients (n = 97) with critical illness polyneuropathy or critical illness myopathy were interviewed via the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, 4th Edition. The diagnosis of the acute stress disorder was assessed within 1 month (t1), the diagnosis of PTSD at 3 (t2) and 6 (t3) months after transfer from the acute care ICU to the post-acute ICU. Patients showing a delayed-onset or persistent course of PTSD were subsumed in one group; 24.7% (n = 24) showed a delayed-onset PTSD. Significant risk factors were as follows: the severity of the medical illness, the perceived fear of dying at the ICU, the number of traumatic memories from the ICU, and the presence of a coronary heart disease. Every fourth patient with CCI showed a delayed-onset PTSD up to 6 months after the ICU treatment. Markers for a delayed-onset PTSD should already be assessed at the time of discharge from the ICU.
[Mh] Termos MeSH primário: Doença Crônica/psicologia
Estado Terminal/psicologia
Unidades de Terapia Intensiva
Doenças Musculares/psicologia
Polineuropatias/psicologia
Índice de Gravidade de Doença
Transtornos de Estresse Pós-Traumáticos/psicologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Doença Crônica/terapia
Estado Terminal/terapia
Feminino
Seres Humanos
Estudos Longitudinais
Masculino
Meia-Idade
Doenças Musculares/complicações
Doenças Musculares/terapia
Polineuropatias/complicações
Polineuropatias/terapia
Fatores de Risco
Transtornos de Estresse Pós-Traumáticos/etiologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.1097/NMD.0000000000000714


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[PMID]:28640120
[Au] Autor:Özdemir G
[Ad] Endereço:Atatürk University Medical Faculty, Department of Neurology, Erzurum City, Turkey.
[Ti] Título:Working hand syndrome: A new definition of non-classified polyneuropathy condition.
[So] Source:Medicine (Baltimore);96(25):e7235, 2017 Jun.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this paper was to define an unexplained non-classified polyneuropathy condition as a new neurological disease. This new diagnosis of occupation related polyneuropathy has been named as "WORKING HAND SYNDROME (WHS)."This study collected and compared clinic and electrophysiological analyze data from healthy controls, WHS patients, carpal tunnel syndrome (CTS) patients and polyneuropathy patients. The WHS patients presented to the clinic with pain, numbness, tingling, and burning sensations in their hands that increased significantly during rest and nighttime. However, there was no weakness in the muscles, and the deep tendon reflexes were normal in this disease. The patients had all been working in physically demanding jobs requiring the use of their hands/arms for at least 1 year, but no vibrating tools were used by the patients. All of the cases were men. I supposed that overload caused by an action repeated chronically by the hand/arm may impair the sensory nerves in mentioned hand/arm. In patients with these complaints, for a definitive diagnosis, similar diseases must be excluded. Nonetheless, the specific electrophysiological finding that the sural nerves are normal on the lower sides, as well as the occurrence of sensory axonal polyneuropathy in the sensory nerves without a significant effect on velocity and latency in the work-ups of the upper extremity are enough to make a diagnosis.In conclusion, WHS has been defined as a polyneuropathy and occupational disease. Patients with WHS present with pain, numbness, tingling, and burning sensations in their hands that increases significantly during rest and nighttime. They also use their arms/hands for jobs that require heavy labor. The neurological examinations of patients with WHS are normal. Only the sensory nerves in the upper extremities are affected. This article is suggested to serve as a resource for patients, health care professionals, and members of the neurology community at large.
[Mh] Termos MeSH primário: Transtornos Traumáticos Cumulativos/classificação
Mãos
Doenças Profissionais/classificação
Doenças do Sistema Nervoso Periférico/classificação
Polineuropatias/classificação
[Mh] Termos MeSH secundário: Síndrome do Túnel Carpal/diagnóstico
Síndrome do Túnel Carpal/fisiopatologia
Transtornos Traumáticos Cumulativos/diagnóstico
Transtornos Traumáticos Cumulativos/fisiopatologia
Diagnóstico Diferencial
Eletromiografia
Mãos/fisiopatologia
Seres Humanos
Masculino
Nervo Mediano/fisiopatologia
Meia-Idade
Condução Nervosa
Doenças Profissionais/diagnóstico
Doenças Profissionais/fisiopatologia
Doenças do Sistema Nervoso Periférico/diagnóstico
Doenças do Sistema Nervoso Periférico/fisiopatologia
Polineuropatias/diagnóstico
Polineuropatias/fisiopatologia
Reflexo
Nervo Sural/fisiopatologia
Síndrome
Terminologia como Assunto
Nervo Ulnar/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007235


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[PMID]:28631805
[Au] Autor:Warendorf J; Vrancken AF; van Schaik IN; Hughes RA; Notermans NC
[Ad] Endereço:Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, Netherlands, 3584 CX.
[Ti] Título:Drug therapy for chronic idiopathic axonal polyneuropathy.
[So] Source:Cochrane Database Syst Rev;6:CD003456, 2017 06 20.
[Is] ISSN:1469-493X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Chronic idiopathic axonal polyneuropathy (CIAP) is an insidiously progressive sensory or sensorimotor polyneuropathy that affects elderly people. Although severe disability or handicap does not occur, CIAP reduces quality of life. CIAP is diagnosed in 10% to 25% of people referred for evaluation of polyneuropathy. There is a need to gather and review emerging evidence on treatments, as the number of people affected is likely to increase in ageing populations. This is an update of a review first published in 2004 and previously updated in 2006, 2008, 2011 and 2013. OBJECTIVES: To assess the effects of drug therapy for chronic idiopathic axonal polyneuropathy for reducing disability and ameliorating neurological symptoms and associated impairments, and to assess any adverse effects of treatment. SEARCH METHODS: In July 2016, we searched Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Reviews in the Cochrane Library, MEDLINE, Embase, and the Web of Science. We searched two trials registries for ongoing trials. We also handsearched the reference lists of relevant articles, reviews and textbooks identified electronically, and we would have contacted authors and other experts in the field to identify additional studies if this seemed useful. SELECTION CRITERIA: We sought all randomised or quasi-randomised (alternate or other systematic treatment allocation) trials that examined the effects of any drug therapy in people with CIAP at least one year after the onset of treatment. People with CIAP had to fulfil the following criteria: age 40 years or older, distal sensory or sensorimotor polyneuropathy, absence of systemic or other neurological disease, chronic clinical course not reaching a nadir in less than two months, exclusion of any recognised cause of the polyneuropathy by medical history taking, clinical or laboratory investigations, and electrophysiological studies in agreement with axonal polyneuropathy, without evidence of demyelinating features. The primary outcome was the proportion of participants with a significant improvement in disability. Secondary outcomes were change in the mean disability score, change in the proportion of participants who make use of walking aids, change in the mean Medical Research Council sum score, degree of pain relief and/or reduction of other positive sensory symptoms, change in the proportion of participants with pain or other positive sensory symptoms, and frequency of adverse effects. DATA COLLECTION AND ANALYSIS: Two review authors independently reviewed the results of the literature search and extracted details of trial methodology and outcome data of all potentially relevant trials. MAIN RESULTS: We identified 39 studies and assessed them for possible inclusion in the review, but we excluded all of them because of insufficient quality or lack of relevance. We summarised evidence from non-randomised studies in the Discussion. AUTHORS' CONCLUSIONS: Even though CIAP has been clearly described and delineated, no adequate randomised or quasi-randomised controlled clinical treatment trials have been performed. In their absence there is no proven efficacious drug therapy.
[Mh] Termos MeSH primário: Perna (Membro)/inervação
Polineuropatias/tratamento farmacológico
[Mh] Termos MeSH secundário: Idoso
Axônios
Doença Crônica
Marcha Atáxica/tratamento farmacológico
Marcha Atáxica/etiologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE
[do] DOI:10.1002/14651858.CD003456.pub3


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[PMID]:28614534
[Au] Autor:Nienov OH; Matte L; Dias LS; Schmid H
[Ad] Endereço:Health Sciences Graduate Program, Obstetrics and Gynecology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
[Ti] Título:Peripheral polyneuropathy in severely obese patients with metabolic syndrome but without diabetes: Association with low HDL-cholesterol.
[So] Source:Rev Assoc Med Bras (1992);63(4):324-331, 2017 Apr.
[Is] ISSN:1806-9282
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Introduction:: The purpose of this study was to evaluate the prevalence of peripheral polyneuropathy (PPN) in subjects with grade II and III obesity (Ob-II,III) and metabolic syndrome (MetS) but without diabetes and to investigate possible associated factors. Method:: A cross-sectional study was performed in non-diabetic Ob-II,III,MetS patients using the Michigan Neuropathy Screening Instrument (MNSI) to assess the presence of PPN. Results:: A total of 24 of 218 non-diabetic Ob-II,III,MetS patients had PPN. Based on univariate analysis, serum levels of LDL-cholesterol (p=0.046) were significantly associated with PPN, while serum triglycerides (p=0.118) and low HDL-cholesterol (p=0.057) showed a tendency toward this association. On a Poisson regression analysis, when the three possible associations were included, low HDL-cholesterol (p=0.047) remained independently associated. Conclusion:: In non-diabetic Ob-II,III,MetS patients, PPN defined by the MNSI showed a high prevalence and was associated with low levels of HDL-cholesterol. In order to diagnose that complication, neurological evaluation should be performed in these patients.
[Mh] Termos MeSH primário: Hipoalfalipoproteinemias/complicações
Síndrome Metabólica/complicações
Obesidade Mórbida/complicações
Polineuropatias/epidemiologia
Polineuropatias/etiologia
[Mh] Termos MeSH secundário: Adulto
Antropometria
Glicemia/análise
Brasil/epidemiologia
Estudos Transversais
Feminino
Seres Humanos
Hipoalfalipoproteinemias/metabolismo
Hipoalfalipoproteinemias/fisiopatologia
Masculino
Síndrome Metabólica/fisiopatologia
Obesidade Mórbida/metabolismo
Obesidade Mórbida/fisiopatologia
Distribuição de Poisson
Polineuropatias/metabolismo
Polineuropatias/fisiopatologia
Prevalência
Estudos Prospectivos
Fatores de Risco
Estatísticas não Paramétricas
Inquéritos e Questionários
Triglicerídeos/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Triglycerides)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE


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[PMID]:28601286
[Au] Autor:Mathey EK; Garg N; Park SB; Nguyen T; Baker S; Yuki N; Yiannikas C; Lin CS; Spies JM; Ghaoui R; Barnett MH; Vucic S; Pollard JD; Kiernan MC
[Ad] Endereço:Brain & Mind Centre, University of Sydney, Sydney, Australia. Electronic address: emily.mathey@sydney.edu.au.
[Ti] Título:Autoantibody responses to nodal and paranodal antigens in chronic inflammatory neuropathies.
[So] Source:J Neuroimmunol;309:41-46, 2017 Aug 15.
[Is] ISSN:1872-8421
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Autoantibodies to nodal/paranodal proteins have been reported in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN). To determine the frequency of anti-paranodal antibodies in our cohort of CIDP patients and to validate the presence anti-nodal antibodies in MMN, sera were screened for IgG against human neurofascin 155, contactin-1, neurofascin 186 and gliomedin using ELISA. In CIDP patients, 7% were anti-NF155 IgG positive and 7% were anti-CNTN1 IgG positive. Positive results were confirmed using cell based assays and indirect immunofluorescence on teased nerve fibres. We did not detect IgG autoantibodies against these nodal/paranodal antigens in MMN patients.
[Mh] Termos MeSH primário: Autoanticorpos/sangue
Polineuropatias/sangue
Polineuropatias/diagnóstico
Polirradiculoneuropatia Desmielinizante Inflamatória Crônica/sangue
Polirradiculoneuropatia Desmielinizante Inflamatória Crônica/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Animais
Autoanticorpos/imunologia
Moléculas de Adesão Celular/sangue
Moléculas de Adesão Celular/imunologia
Feminino
Células HeLa
Seres Humanos
Imunoglobulina G/sangue
Imunoglobulina G/imunologia
Masculino
Proteínas de Membrana/sangue
Proteínas de Membrana/imunologia
Meia-Idade
Fatores de Crescimento Neural/sangue
Fatores de Crescimento Neural/imunologia
Proteínas do Tecido Nervoso/sangue
Proteínas do Tecido Nervoso/imunologia
Polineuropatias/imunologia
Polirradiculoneuropatia Desmielinizante Inflamatória Crônica/imunologia
Ratos
Ratos Endogâmicos Lew
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Autoantibodies); 0 (Cell Adhesion Molecules); 0 (GLDN protein, human); 0 (Immunoglobulin G); 0 (Membrane Proteins); 0 (NFASC protein, human); 0 (Nerve Growth Factors); 0 (Nerve Tissue Proteins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170612
[St] Status:MEDLINE



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