[PMID]: | 27684550 |
[Au] Autor: | Di Ciaula A; Grattagliano I; Portincasa P |
[Ad] Endereço: | Division of Internal Medicine, Hospital of Bisceglie, Italy. |
[Ti] Título: | Chronic alcoholics retain dyspeptic symptoms, pan-enteric dysmotility, and autonomic neuropathy before and after abstinence. |
[So] Source: | J Dig Dis;17(11):735-746, 2016 Nov. |
[Is] ISSN: | 1751-2980 |
[Cp] País de publicação: | Australia |
[La] Idioma: | eng |
[Ab] Resumo: | OBJECTIVE: To carry out a comprehensive study on gastrointestinal symptoms, motility and autonomic neuropathy in chronic alcoholics before and one year after abstinence. METHODS: Dyspeptic symptoms (questionnaires), fasting and postprandial gallbladder and gastric motility (ultrasonography), oro-cecal transit time (lactulose H -breath test), stool form score (indirect marker of colonic transit), and autonomic neuropathy (sweat spot test, R-R ratio) were assessed at baseline in 268 subjects (136 chronic alcoholics and 132 healthy controls). A subgroup of 39 patients was re-evaluated after 12 months of abstinence. RESULTS: Chronic alcoholics had increased dyspepsia, delayed gastric emptying and oro-cecal transit time but faster gallbladder emptying, with slightly accelerated colonic transit. Sympathetic, but not parasympathetic, autonomic dysfunction was found. Dyspeptic symptoms and functional alterations of gastric emptying and oro-cecal transit tests were still present after 12-month abstinence, whereas gallbladder motility, stool form score and sympathetic function improved. CONCLUSIONS: Chronic alcoholics exhibit combined and interdependent presence of dyspeptic symptoms, impaired motility at different levels of the gastrointestinal tract, with sympathetic dysfunction. Only a few of these abnormalities improve after one year of abstinence from alcohol. |
[Mh] Termos MeSH primário: |
Abstinência de Álcool Alcoolismo/fisiopatologia Doenças do Sistema Nervoso Autônomo/fisiopatologia Dispepsia/fisiopatologia Gastroenteropatias/fisiopatologia Motilidade Gastrointestinal/fisiologia
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[Mh] Termos MeSH secundário: |
Adulto Neuropatia Alcoólica/etiologia Neuropatia Alcoólica/fisiopatologia Alcoólicos Alcoolismo/complicações Doenças do Sistema Nervoso Autônomo/etiologia Doença Crônica Dispepsia/etiologia Feminino Gastroenteropatias/etiologia Seres Humanos Masculino Inquéritos e Questionários
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[Pt] Tipo de publicação: | JOURNAL ARTICLE; OBSERVATIONAL STUDY |
[Em] Mês de entrada: | 1704 |
[Cu] Atualização por classe: | 170426 |
[Lr] Data última revisão:
| 170426 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 160930 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1111/1751-2980.12415 |
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