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Barraviera, Benedito
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[PMID]:28450050
[Au] Autor:Araújo MR; Kyrylenko S; Spejo AB; Castro MV; Ferreira Junior RS; Barraviera B; Oliveira ALR
[Ad] Endereço:Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas, Sao Paulo, Brazil.
[Ti] Título:Transgenic human embryonic stem cells overexpressing FGF2 stimulate neuroprotection following spinal cord ventral root avulsion.
[So] Source:Exp Neurol;294:45-57, 2017 08.
[Is] ISSN:1090-2430
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ventral root avulsion (VRA) triggers a strong glial reaction which contributes to neuronal loss, as well as to synaptic detachment. To overcome the degenerative effects of VRA, treatments with neurotrophic factors and stem cells have been proposed. Thus, we investigated neuroprotection elicited by human embryonic stem cells (hESC), modified to overexpress a human fibroblast growth factor 2 (FGF-2), on motoneurons subjected to VRA. Lewis rats were submitted to VRA (L4-L6) and hESC/FGF-2 were applied to the injury site using a fibrin scaffold. The spinal cords were processed to evaluate neuronal survival, synaptic stability, and glial reactivity two weeks post lesion. Then, qRT-PCR was used to assess gene expression of ß2-microglobulin (ß2m), TNFα, IL1ß, IL6 and IL10 in the spinal cord in vivo and FGF2 mRNA levels in hESC in vitro. The results indicate that hESC overexpressing FGF2 significantly rescued avulsed motoneurons, preserving synaptic covering and reducing astroglial reactivity. The cells were also shown to express BDNF and GDNF at the site of injury. Additionally, engraftment of hESC led to a significant reduction in mRNA levels of TNFα at the spinal cord ventral horn, indicating their immunomodulatory properties. Overall, the present data suggest that hESC overexpressing FGF2 are neuroprotective and can shift gene expression towards an anti-inflammatory environment.
[Mh] Termos MeSH primário: Células-Tronco Embrionárias Humanas/transplante
Radiculopatia/cirurgia
Raízes Nervosas Espinhais/patologia
[Mh] Termos MeSH secundário: Animais
Movimento Celular
Sobrevivência Celular/efeitos dos fármacos
Sobrevivência Celular/genética
Modelos Animais de Doenças
Doxiciclina/uso terapêutico
Feminino
Adesivo Tecidual de Fibrina/toxicidade
Fator 2 de Crescimento de Fibroblastos/genética
Fator 2 de Crescimento de Fibroblastos/metabolismo
Regulação da Expressão Gênica/efeitos dos fármacos
Regulação da Expressão Gênica/genética
Vetores Genéticos/fisiologia
Células-Tronco Embrionárias Humanas/metabolismo
Seres Humanos
Neurônios Motores/metabolismo
Neurônios Motores/patologia
Proteínas do Tecido Nervoso/metabolismo
Neuroglia/efeitos dos fármacos
Neuroglia/metabolismo
Radiculopatia/induzido quimicamente
Ratos
Ratos Endogâmicos Lew
Adesivos Teciduais/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Fibrin Tissue Adhesive); 0 (Nerve Tissue Proteins); 0 (Tissue Adhesives); 103107-01-3 (Fibroblast Growth Factor 2); N12000U13O (Doxycycline)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180218
[Lr] Data última revisão:
180218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:29252636
[Au] Autor:Briem T; Haemmerle G; Kramers-de Quervain I; Leunig M
[Ad] Endereço:Departments of Orthopaedics-Lower Extremities (T.B. and M.L.), Manual Medicine (G.H.), and Rheumatology (I.K.-de Q.), Schulthess Clinic, Zurich, Switzerland.
[Ti] Título:Synovial Ganglion of the Hip as a Rare Cause of L5 Radiculopathy: A Case Report.
[So] Source:JBJS Case Connect;6(3):e59, 2016 Jul-Sep.
[Is] ISSN:2160-3251
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CASE: We report a rare case of a dorsal synovial ganglion of the left hip causing L5 radiculopathy in a 48-year-old woman. After a 12-month history of intermittent pain in the groin, left buttock, and left lower limb, magnetic resonance imaging (MRI) of the pelvis revealed a 10-cm-long cystic ganglion. The lesion originated from the posterior aspect of the hip joint capsule and extended through the sciatic notch toward the L5 nerve root, causing severe nerve compression. Open resection of the ganglion via surgical hip subluxation was performed. CONCLUSION: Combined presentation of symptoms attributable to intrinsic hip disease and peripheral radiculopathy should raise suspicion for a shared cause of these entities.
[Mh] Termos MeSH primário: Cistos Glanglionares/diagnóstico
Articulação do Quadril/diagnóstico por imagem
Radiculopatia/etiologia
Cisto Sinovial/diagnóstico
[Mh] Termos MeSH secundário: Feminino
Cistos Glanglionares/complicações
Articulação do Quadril/cirurgia
Seres Humanos
Meia-Idade
Cisto Sinovial/complicações
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.2106/JBJS.CC.15.00234


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[PMID]:29381941
[Au] Autor:Wang F; Hou HT; Wang P; Zhang JT; Shen Y
[Ad] Endereço:Department of Spine Surgery, The Third Hospital of Hebei Medical University, The Key Laboratory of Orthopedic Biomechanics of Hebei Province.
[Ti] Título:Symptomatic adjacent segment disease after single-lever anterior cervical discectomy and fusion: Incidence and risk factors.
[So] Source:Medicine (Baltimore);96(47):e8663, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to determine the incidence and risk factors of symptomatic adjacent segment disease (ASD) following single-lever anterior cervical discectomy and fusion (ACDF) for cervical degenerative diseases.From January 2000 to December 2010, a total of 582 patients with cervical radiculopathy and myelopathy who had undergone single-lever ACDF surgery in the authors' institution were reviewed retrospectively. Patients who had a revision surgery for symptomatic ASD were selected for this study. The authors analyzed the incidence for ASD after single-lever ACDF. And univariate analysis and logistic regression analysis were performed to identify the risk factors of ASD.Among the 582 patients, 36 patients received subsequent surgical management for ASD after initial single-lever ACDF for an overall prevalence of 6.2%. The average onset time of ASD was 8.5 (2-15) years. The univariate analysis showed that there were no significant differences in sex, duration of disease, BMI, DM, smoking, operative levels, and follow-up period (P > .05) between the 2 groups with and without ASD. There were statistically significant differences in age at the time of operation (χ = 4.361, P = .037), and developmental canal stenosis (χ = 4.181, P = .041) between patients with and without ASD. The variables of age at the time of operation and developmental canal stenosis were included in a logistic regression model. The logistic regression analysis revealed that age at the time of operation ≤50 years (P = .045, OR = 3.015, 95% CI = 1.024-8.882) and developmental canal stenosis (P = .042, OR = 2.797, 95% CI = 1.039-7.527) were the risk factors for ASD after single-lever ACDF.In the present study, the incidence of symptomatic ASD after single-lever ACDF was 6.2%. And the age at the time of operation ≤50 years and developmental canal stenosis were the risk factors for ASD. The patients ≤50 years old at the time of operation or with developmental canal stenosis are more likely to develop ASD after surgery, and the risk of reoperation will increase.
[Mh] Termos MeSH primário: Discotomia/efeitos adversos
Degeneração do Disco Intervertebral
Complicações Pós-Operatórias
Radiculopatia/cirurgia
Reoperação/estatística & dados numéricos
Doenças da Medula Espinal/cirurgia
Fusão Vertebral/efeitos adversos
Estenose Espinal
[Mh] Termos MeSH secundário: Fatores Etários
Vértebras Cervicais/diagnóstico por imagem
Vértebras Cervicais/patologia
Vértebras Cervicais/cirurgia
China/epidemiologia
Discotomia/métodos
Feminino
Seres Humanos
Incidência
Degeneração do Disco Intervertebral/diagnóstico
Degeneração do Disco Intervertebral/epidemiologia
Degeneração do Disco Intervertebral/etiologia
Degeneração do Disco Intervertebral/cirurgia
Masculino
Meia-Idade
Avaliação de Processos e Resultados (Cuidados de Saúde)
Complicações Pós-Operatórias/diagnóstico
Complicações Pós-Operatórias/epidemiologia
Complicações Pós-Operatórias/cirurgia
Estudos Retrospectivos
Fatores de Risco
Fusão Vertebral/métodos
Estenose Espinal/diagnóstico
Estenose Espinal/epidemiologia
Estenose Espinal/etiologia
Estenose Espinal/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008663


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Registro de Ensaios Clínicos
[PMID]:27770801
[Au] Autor:Yang F; Li WX; Liu Z; Liu L
[Ad] Endereço:Shaanxi University of Chinese Medicine, Xi'an, 712000, China. yangfengdudu@163.com.
[Ti] Título:Balance chiropractic therapy for cervical spondylotic radiculopathy: study protocol for a randomized controlled trial.
[So] Source:Trials;17(1):513, 2016 10 22.
[Is] ISSN:1745-6215
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cervical spondylosis is a very common disorder and cervical spondylotic radiculopathy (CSR) is the most common form of spinal degenerative disease. Its clinical manifestations focus on pain and numbness of the neck and arm as well as restricted movement of the neck, which greatly affect the patient's life and work. The orthopedic of traditional Chinese medicine (TCM) theory holds that the basic pathologic change in spinal degenerative diseases is the imbalance between the dynamic system and the static system of the cervical spine. Based on this theory, some Chinese physicians have developed a balance chiropractic therapy (BCT) to treat CSR, which has been clinically examined for more than 50 years to effectively cure CSR. The purpose of this study is to evaluate the therapeutic effect and safety of BCT on CSR and to investigate the mechanism by which the efficacy is achieved. METHODS/DESIGN: We propose a multicenter, parallel-group, randomized controlled trial to evaluate the efficacy and safety of BCT for CSR. Participants aged 18 to 65 years, who are in conformity with the diagnostic criteria of CSR and whose pain score on a Visual Analog Scale (VAS) is more than 4 points and less than 8 points, will be included and randomly allocated into two groups: a treatment group and a control group. Participants in the treatment group will be treated with BCT, while the control group will receive traction therapy (TT). The primary outcome is pain severity (measured with a VAS). Secondary outcomes will include cervical curvature (measured by the Borden Index), a composite of functional status (measured by the Neck Disability Index, NDI), patient health status (evaluated by the SF-36 health survey) and adverse events (AEs) as reported in the trial. DISCUSSION: If BCT can relieve neck pain without adverse effects, it may be a novel strategy for the treatment of CSR. Furthermore, the mechanism of BCT for CSR will be partially elucidated. TRIAL REGISTRATION: Clinical Trials.gov Identifier: NCT02705131 . Registered on 9 March 2016.
[Mh] Termos MeSH primário: Protocolos Clínicos
Manipulação Quiroprática/métodos
Radiculopatia/terapia
Espondilose/terapia
[Mh] Termos MeSH secundário: Vértebras Cervicais
Seres Humanos
Tamanho da Amostra
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE


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[PMID]:28451842
[Au] Autor:de Rooij JD; Gadjradj PS; Soria van Hoeve JS; Harhangi BS
[Ad] Endereço:Department of Neurosurgery, Erasmus MC: University Medical Center Rotterdam, S-Gravendijkwal 230 HS-205, 3015 CE, Rotterdam, The Netherlands. j.derooij@erasmusmc.nl.
[Ti] Título:Anterior cervical discectomy without fusion for a symptomatic cervical disk herniation.
[So] Source:Acta Neurochir (Wien);159(7):1283-1287, 2017 Jul.
[Is] ISSN:0942-0940
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cervical radiculopathy is characterized by dysfunction of the nerve root usually caused by a cervical disk herniation. The most important symptom is pain, radiating from the neck to the arm. When conservative treatment fails, surgical treatment is indicated to relieve symptoms. During the last decades, multiple fusion techniques have been developed, although without clinical evidence for added value of fusion over non-fusion. METHODS: The surgical procedure of anterior cervical discectomy without fusion is performed step by step, leading to removal of the entire intervertebral disk. CONCLUSION: Anterior cervical discectomy without fusion is a safe and effective treatment for cervical disk herniation.
[Mh] Termos MeSH primário: Discotomia/métodos
Deslocamento do Disco Intervertebral/cirurgia
Complicações Pós-Operatórias/prevenção & controle
Radiculopatia/cirurgia
Fusão Vertebral/métodos
[Mh] Termos MeSH secundário: Vértebras Cervicais/cirurgia
Discotomia/efeitos adversos
Seres Humanos
Disco Intervertebral/cirurgia
Fusão Vertebral/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1007/s00701-017-3189-x


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[PMID]:29182113
[Au] Autor:Li X; Xu L; Kong Q
[Ti] Título:Fusion-segment of high-grade Lumbar Spondylolisthesis: 2-year follow-up.
[So] Source:Acta Orthop Belg;82(4):730-736, 2016 Dec.
[Is] ISSN:0001-6462
[Cp] País de publicação:Belgium
[La] Idioma:eng
[Ab] Resumo:The clinical efficacy of reduction and fusion surgery and the suitable range of fusion-segment were evaluated in 12 pediatric patients treated for high-grade spondylolisthesis. Pre/post-operative clinical and radiological assessments were analyzed. A transient L5 nerve root paralysis was observed in one patient with L5 spondylolisthesis. No degenerative spondylolisthesis or adjacent segmental instability occurred above the fusion segments. In conclusion, we suggest that, in case of spondylolisthesis without severe structural scoliosis deformity or only associated with lumbosacral deformity, the posterior ligament complex should be protected in case of adjacent segmental instability and spondylolisthesis. If the spondylolisthesis is complicated with severe structural scoliosis deformity (Cobb ≥ 70°), in principle, the treatment should be performed according to the characteristics of the two diseases respectively.
[Mh] Termos MeSH primário: Vértebras Lombares/cirurgia
Fusão Vertebral/métodos
Espondilolistese/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Transplante Ósseo
Criança
Descompressão Cirúrgica
Feminino
Seguimentos
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Complicações Pós-Operatórias/epidemiologia
Radiculopatia/epidemiologia
Remissão Espontânea
Índice de Gravidade de Doença
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171228
[Lr] Data última revisão:
171228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE


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[PMID]:28850600
[Au] Autor:Donk RD; Verbeek ALM; Verhagen WIM; Groenewoud H; Hosman AJF; Bartels RHMA
[Ad] Endereço:Via Sana Clinics, Department of Orthopedic Surgery, Mill, the Netherlands.
[Ti] Título:What's the best surgical treatment for patients with cervical radiculopathy due to single-level degenerative disease? A randomized controlled trial.
[So] Source:PLoS One;12(8):e0183603, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To investigate the efficacy of adding supplemental fusion or arthroplasty after cervical anterior discectomy for symptomatic mono-level cervical degenerative disease (radiculopathy), which has not been substantiated in controlled trials until now. METHODS: A randomized controlled trial is reported with 9 years follow up comparing anterior cervical anterior discectomy without fusion, with fusion by cage standalone, or with disc prosthesis. Patients suffering from symptomatic cervical disk degeneration at one level referred to spinal sections of department of neurosurgery or orthopedic surgery of a large general hospital with educational facilities were eligible. Neck Disability Index (NDI), McGill Pain Questionnaire Dutch language version (MPQ-DLV), physical-component summary (PCS), and mental-component summary (MCS) of the 36-item Short-Form Health Survey (SF-36), and re operation rate were evaluated. FINDINGS: 142 patients between 18 and 55 years were allocated. The median follow-up was 8.9±1.9 years (5.6 to 12.2 years). The response rate at last follow-up was 98.5%. NDI at the last follow-up did not differ between the three treatment groups, nor did the secondary outcomes as MPQ-DLV and PCS or MCS from SF-36. The major improvement occurred within the first 6 weeks after surgery. Afterward, it remained stable. Eleven patients underwent surgery for recurrent symptoms and signs due to nerve root compression at the index or adjacent level. CONCLUSIONS: This randomized trial could not detect a difference between three surgical modalities for treating a single-level degenerative disk disease. Anterior cervical discectomy without implant seems to be similar to anterior cervical discectomy with fusion by cage stand-alone or with disk prosthesis. Due to the small study sample size, this statement should be considered as inconclusive so far. TRIAL REGISTRATION: ISRCTN41681847.
[Mh] Termos MeSH primário: Vértebras Cervicais/cirurgia
Degeneração do Disco Intervertebral/cirurgia
Radiculopatia/cirurgia
Fusão Vertebral/métodos
Substituição Total de Disco/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Avaliação da Deficiência
Feminino
Seguimentos
Seres Humanos
Degeneração do Disco Intervertebral/complicações
Masculino
Meia-Idade
Radiculopatia/etiologia
Fusão Vertebral/efeitos adversos
Substituição Total de Disco/efeitos adversos
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183603


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[PMID]:28807894
[Au] Autor:Cohen SP; Hooten WM
[Ad] Endereço:Departments of Anesthesiology and Critical Care Medicine, Neurology and Physical Medicine and Rehabilitation, Johns Hopkins School of Medicine, Baltimore, MD 21029, USA scohen40@jhmi.edu.
[Ti] Título:Advances in the diagnosis and management of neck pain.
[So] Source:BMJ;358:j3221, 2017 Aug 14.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Neck pain imposes a considerable personal and socioeconomic burden-it is one of the top five chronic pain conditions in terms of prevalence and years lost to disability-yet it receives a fraction of the research funding given to low back pain. Although most acute episodes resolve spontaneously, more than a third of affected people still have low grade symptoms or recurrences more than one year later, with genetics and psychosocial factors being risk factors for persistence. Nearly half of people with chronic neck pain have mixed neuropathic-nociceptive symptoms or predominantly neuropathic symptoms. Few clinical trials are dedicated solely to neck pain. Muscle relaxants and non-steroidal anti-inflammatory drugs are effective for acute neck pain, and clinical practice is mostly guided by the results of studies performed for other chronic pain conditions. Among complementary and alternative treatments, the strongest evidence is for exercise, with weaker evidence supporting massage, acupuncture, yoga, and spinal manipulation in different contexts. For cervical radiculopathy and facet arthropathy, weak evidence supports epidural steroid injections and radiofrequency denervation, respectively. Surgery is more effective than conservative treatment in the short term but not in the long term for most of these patients, and clinical observation is a reasonable strategy before surgery.
[Mh] Termos MeSH primário: Cervicalgia/diagnóstico
Cervicalgia/terapia
[Mh] Termos MeSH secundário: Dor Aguda/diagnóstico
Dor Aguda/terapia
Dor Crônica/diagnóstico
Dor Crônica/terapia
Terapias Complementares
Diagnóstico Diferencial
Exercício
Guias como Assunto
Seres Humanos
Manipulação da Coluna/métodos
Cervicalgia/fisiopatologia
Cervicalgia/psicologia
Radiculopatia/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170816
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j3221


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[PMID]:28767566
[Au] Autor:Cui XJ; Yao M; Ye XL; Wang P; Zhong WH; Zhang RC; Li HY; Hu ZJ; Tang ZY; Wang WM; Qiao WP; Sun YL; Li J; Gao Y; Shi Q; Wang Y
[Ad] Endereço:aLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai bFirst Teaching Hospital, Tianjin University of Traditional Chinese Medicine, Tianjin cRehabilitation Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou dXinjiang Uygur Autonomous Region Hospital of traditional Chinese Medicine, Urumqi eFirst Affiliated Hospital, Henan University of Traditional Chinese Medicine, Zhengzhou, China.
[Ti] Título:Shi-style cervical manipulations for cervical radiculopathy: A multicenter randomized-controlled clinical trial.
[So] Source:Medicine (Baltimore);96(31):e7276, 2017 Aug.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: There is a lack of high-quality evidence supporting the use of manipulation therapy for patients with cervical radiculopathy (CR). This study aimed to evaluate the effectiveness of Shi-style cervical manipulations (SCMs) versus mechanical cervical traction (MCT) for CR. METHODS: This was a randomized, open-label, controlled trial carried out at 5 hospitals in patients with CR for at least 2 weeks and neck pain. The patients received 6 treatments of SCM (n = 179) or MCT (n = 180) over 2 weeks. The primary outcome was participant-rated disability (neck disability index), measured 2 weeks after randomization. The secondary outcomes were participant-rated pain (visual analog scale) and health-related quality of life (36-Item Short Form Health Survey [SF-36]). Assessments were performed before, during, and after (2, 4, 12, and 24 weeks) intervention. RESULTS: After 2 weeks of treatment, the SCM group showed a greater improvement in participant-rated disability compared with the control group (P = .018). The SCM group reported less disability compared with the control group (P < .001) during the 26-week follow-up. The difference was particularly important at 6 months (mean -28.91 ±â€Š16.43, P < .001). Significant improvements in SF-36 were noted in both groups after 2 weeks of treatment, but there were no differences between the 2 groups. CONCLUSION: SCM could be a better option than MCT for the treatment of CR-related pain and disability.
[Mh] Termos MeSH primário: Manipulação da Coluna
Radiculopatia/terapia
[Mh] Termos MeSH secundário: Adulto
Vértebras Cervicais
Avaliação da Deficiência
Feminino
Seguimentos
Seres Humanos
Masculino
Manipulação da Coluna/efeitos adversos
Manipulação da Coluna/métodos
Cervicalgia/etiologia
Cervicalgia/terapia
Medição da Dor
Cooperação do Paciente
Qualidade de Vida
Radiculopatia/complicações
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007276


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[PMID]:28705700
[Au] Autor:Koustais S; O'Halloran PJ; Hassan A; Brett F; Young S
[Ad] Endereço:Department of Neurosurgery, Beaumont Hospital, Dublin, Ireland. Electronic address: stavroskoustais@beaumont.ie.
[Ti] Título:Incidental Primary Intradural Carcinoid Tumor in a Patient with Lumbar Radiculopathy.
[So] Source:World Neurosurg;105:1042.e11-1042.e14, 2017 Sep.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Carcinoid tumors are neuroendocrine neoplasms derived from enterochromaffin cells. Central nervous system involvement is rare. The reported cases include metastases to brain or spinal cord, and primary skeletal or extradural disease resulting in compressive myeloradiculopathy. There are 2 previously reported cases of primary intradural extramedullary carcinoid tumor, presenting with compressive symptoms. We report the first case of primary incidental intradural extramedullary carcinoid tumor. CASE DESCRIPTION: A 68-year-old man was complaining of a 2-month history of left-sided back pain and sciatica; however, he presented with acutely worse symptoms of severe left sciatica. There was no sphincter dysfunction nor power deficit on examination. A magnetic resonance imaging (MRI) scan of the lumbar spine revealed an L4-5 central disk protrusion causing left L5 nerve root compression, and a heterogeneous enhancing intradural mass at the L2-3 level displacing the cauda equina. An L4-5 microdiscectomy followed by an L2-3 laminectomy and resection of the intradural mass was performed. There was a postoperative left S1 paresthesia that was managed medically; however, the postoperative period was unremarkable. A postoperative MRI of the lumbar spine showed complete resection of the mass. A staging scan revealed an incidental thyroid nodule; however, there was no other disease burden. Histopathology of the resected specimen revealed a primary spinal carcinoid tumor. CONCLUSIONS: To our knowledge, this is the first reported case of incidental primary intradural spinal carcinoid tumor. Even though intradural spinal carcinoid tumors are exceedingly rare, they should be included in the differential diagnosis of enhancing intradural lesions.
[Mh] Termos MeSH primário: Tumor Carcinoide/diagnóstico por imagem
Achados Incidentais
Vértebras Lombares/diagnóstico por imagem
Radiculopatia/diagnóstico por imagem
Neoplasias da Medula Espinal/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso
Tumor Carcinoide/complicações
Tumor Carcinoide/cirurgia
Seres Humanos
Vértebras Lombares/cirurgia
Masculino
Radiculopatia/complicações
Radiculopatia/cirurgia
Neoplasias da Medula Espinal/complicações
Neoplasias da Medula Espinal/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE



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