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Pesquisa : C10.668.829.860 [Categoria DeCS]
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[PMID]:29029847
[Au] Autor:Terkelsen AJ; Karlsson P; Lauria G; Freeman R; Finnerup NB; Jensen TS
[Ad] Endereço:Department of Neurology, Aarhus University Hospital, Aarhus, Denmark; Danish Pain Research Center, Aarhus University, Aarhus, Denmark.
[Ti] Título:The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes.
[So] Source:Lancet Neurol;16(11):934-944, 2017 Nov.
[Is] ISSN:1474-4465
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Small fibre neuropathies are a heterogeneous group of disorders affecting thinly myelinated Aδ-fibres and unmyelinated C-fibres. Although multiple causes of small nerve fibre degeneration have been reported, including via genetic mutations, the cause of small fibre neuropathy remains unknown in up to 50% of cases. The typical clinical presentation of small fibre neuropathy is that of a symmetrical, length-dependent polyneuropathy associated with sensory or autonomic symptoms. More rarely, the clinical presentation is characterised by non-length-dependent, focal, or multifocal symptoms. The diagnostic tests to identify small fibre neuropathy include skin biopsy, quantitative sensory, and autonomic testing. Additional tests, such as those measuring small fibre-related evoked potentials and corneal confocal microscopy, might contribute to a better understanding of these neuropathies. Biochemical markers can also help in screening patients for the presence of small fibre neuropathy and to assess disease progression.
[Mh] Termos MeSH primário: Neuropatia de Pequenas Fibras/diagnóstico
Neuropatia de Pequenas Fibras/etiologia
[Mh] Termos MeSH secundário: Biópsia/métodos
Feminino
Seres Humanos
Masculino
Microscopia Confocal
Condução Nervosa/fisiologia
Pele/patologia
Neuropatia de Pequenas Fibras/genética
Neuropatia de Pequenas Fibras/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171015
[St] Status:MEDLINE


  2 / 30 MEDLINE  
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[PMID]:28957343
[Au] Autor:Hsu JL; Liao MF; Hsu HC; Weng YC; Lo AL; Chang KH; Chang HS; Kuo HC; Huang CC; Ro LS
[Ad] Endereço:Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung University College of Medicine, Taipei, Taiwan.
[Ti] Título:A prospective, observational study of patients with uncommon distal symmetric painful small-fiber neuropathy.
[So] Source:PLoS One;12(9):e0183948, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To investigate the clinical characteristics of patients with uncommon distal symmetric painful small-fiber neuropathy (DSPSFN). METHODS: From September 2012 to September 2014, participants between 18-70 years of age that had DSPSFN defined by clinical signs/symptoms and ID pain > 2 or DN4 > 4 on questionnaires for more than 1 month were included. Participants who had previous historical or laboratory evidence of common etiologies of DSPSFN were excluded. Enzyme activity and genetic studies for Fabry diseaseand familial amyloid polyneuropathy were performed after participants fulfilled the inclusion and exclusion criteria. The cryoglobulin test, autoantibodies studies and electrophysiological studies were performed in these participants. RESULTS: In total, 100 cases were enrolled in the current study. Three cases of subclinical diabetes mellitus and two cases of fibromyalgia were found. Fabry disease (1%) and familial amyloid polyneuropathy (3%) with Ala97Ser transthyretin (TTR) mutations were also detected. The cryoglobulin test was positive in 30% of participants, and these participants had higher DN4 scores than the negative group. In the autoantibodies studies, 59% of the participants had abnormal anti-Ro/SSA and/or anti-La/SSB antibodies. CONCLUSIONS: Cryoglobulinemia is not a rare etiology of uncommon DSPSFN. The long-term prognosis is quite good in these participants. From our structuralized protocol, Fabry disease and familial amyloid polyneuropathy could be easily detected in these cases of uncommon DSPSFN.
[Mh] Termos MeSH primário: Neuropatia de Pequenas Fibras/diagnóstico
[Mh] Termos MeSH secundário: Autoanticorpos/imunologia
Crioglobulinemia/complicações
Demografia
Fenômenos Eletrofisiológicos
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Neuropatia de Pequenas Fibras/complicações
Neuropatia de Pequenas Fibras/imunologia
Neuropatia de Pequenas Fibras/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Autoantibodies)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183948


  3 / 30 MEDLINE  
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[PMID]:28672034
[Au] Autor:Liguori R; Incensi A; de Pasqua S; Mignani R; Fileccia E; Santostefano M; Biagini E; Rapezzi C; Palmieri S; Romani I; Borsini W; Burlina A; Bombardi R; Caprini M; Avoni P; Donadio V
[Ad] Endereço:IRCCS Institute of Neurological Sciences, Bologna, Italy.
[Ti] Título:Skin globotriaosylceramide 3 deposits are specific to Fabry disease with classical mutations and associated with small fibre neuropathy.
[So] Source:PLoS One;12(7):e0180581, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Fabry Disease (FD) is characterized by globotriaosylceramide-3 (Gb3) accumulation in several tissues and a small fibre neuropathy (SFN), however the underlying mechanisms are poorly known. This study aimed to: 1) ascertain the presence of Gb3 deposits in skin samples, by an immunofluorescence method collected from FD patients with classical GLA mutations or late-onset FD variants or GLA polymorphisms; 2) correlate skin GB3 deposits with skin innervation. METHODS: we studied 52 genetically-defined FD patients (32 with classical GLA mutations and 20 with late-onset variants or GLA polymorphisms), 15 patients with SFN associated with a specific cause and 22 healthy controls. Subjects underwent skin biopsy to evaluate Gb3 deposits and epi-dermal innervation. RESULTS: Skin Gb3 deposits were found in all FD patients with classical GLA mutations but never in FD patients with late-onset variants or GLA polymorphisms or in patients with SFN and healthy controls. Abnormal deposits were found inside different skin structures but never inside axons. FD patients with GB3 deposits showed lower skin innervation than FD patients with late-onset variants or polymorphisms. CONCLUSIONS: 1) Skin Gb3 deposits are specific to FD patients with classical GLA mutations; 2) Gb3 deposits were associated with lower skin innervation but they were not found inside axons, suggesting an indirect damage on peripheral small fibre innervation.
[Mh] Termos MeSH primário: Doença de Fabry/genética
Mutação
Neuropatia de Pequenas Fibras/metabolismo
Triexosilceramidas/metabolismo
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Neuropatia de Pequenas Fibras/genética
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Trihexosylceramides); 71965-57-6 (globotriaosylceramide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170704
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180581


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[PMID]:28422829
[Au] Autor:Indart S; Hugon J; Guillausseau PJ; Gilbert A; Dumurgier J; Paquet C; Sène D
[Ad] Endereço:aCognitive Neurology Center AP-HP, Hôpital Lariboisière bINSERM, U942 cUniversity of Paris Diderot, Sorbonne Paris Cité dDepartment of Internal Medicine, AP-HP, Hôpital Lariboisière, INSERM eDepartment of Biochemistry and Molecular Biology, AP-HP, Hôpital Lariboisière, Paris, France.
[Ti] Título:Impact of pain on cognitive functions in primary Sjögren syndrome with small fiber neuropathy: 10 cases and a literature review.
[So] Source:Medicine (Baltimore);96(16):e6384, 2017 Apr.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Primary Sjögren syndrome (pSS) is a chronic systemic autoimmune disease characterized by xerophthalmia, xerostomia, and potential peripheral or central neurological involvement. In pSS, the prevalence of cognitive disorders is generally sparse across literature and the impact of pain on cognitive profile is unclear. The aim of this study was to determine the relation between pain, cognitive complaint, and impairment in a very homogenous population of 10 pSS patients with painful small fiber neuropathy (PSFN) and spontaneous cognitive complaint. Neurological exam, neuropsychological assessment, clinical evaluation measuring pain level, fatigue, anxiety, depression, and cognitive complaint were performed. Our results showed that 100% of patients had cognitive dysfunction especially in executive domain (80%). The most sensitive test was the Wisconsin Card Sorting Test (WCST), abnormal in 70% of our population. Moreover, we found clear cut significant correlations between pain levels and 3 measures of WCST: the number of errors (R = -0.768, P = .0062), perseverations (R = 0.831, P = .0042), and categories (R = 0.705, P = .02). In the literature review, the impact of pain is underexplored and results could be discordant. In a homogeneous cohort of pSS patients with PSFN, a cognitive complaint seems to be a valid reflection of cognitive dysfunction marked by a specific executive profile found with the WCST. In this preliminary study, this profile is linked to the level of pain and highlights that an appropriate management of pain control and a cognitive readaptation in patients could improve the quality of life.
[Mh] Termos MeSH primário: Cognição
Dor/psicologia
Síndrome de Sjogren/psicologia
Neuropatia de Pequenas Fibras/psicologia
[Mh] Termos MeSH secundário: Disfunção Cognitiva/complicações
Disfunção Cognitiva/fisiopatologia
Feminino
Seres Humanos
Meia-Idade
Estudos Observacionais como Assunto
Dor/complicações
Dor/fisiopatologia
Projetos Piloto
Síndrome de Sjogren/complicações
Síndrome de Sjogren/fisiopatologia
Neuropatia de Pequenas Fibras/complicações
Neuropatia de Pequenas Fibras/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000006384


  5 / 30 MEDLINE  
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[PMID]:28414705
[Au] Autor:Gemignani F
[Ad] Endereço:Department of Neurosciences, University of Parma, Parma, Italy.
[Ti] Título:Small fiber neuropathy or small fiber pathology?
[So] Source:Pain;158(5):988-989, 2017 05.
[Is] ISSN:1872-6623
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Fibras Nervosas
Neuropatia de Pequenas Fibras
[Mh] Termos MeSH secundário: Seres Humanos
Doenças do Sistema Nervoso Periférico
Pele
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170607
[Lr] Data última revisão:
170607
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE
[do] DOI:10.1097/j.pain.0000000000000835


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[PMID]:28369282
[Au] Autor:von Bischhoffshausen S; Ivulic D; Alvarez P; Schuffeneger VC; Idiaquez J; Fuentes C; Morande P; Fuentes I; Palisson F; Bennett DLH; Calvo M
[Ad] Endereço:Facultad de Medicina, Universidad de los Andes, Chile.
[Ti] Título:Recessive dystrophic epidermolysis bullosa results in painful small fibre neuropathy.
[So] Source:Brain;140(5):1238-1251, 2017 May 01.
[Is] ISSN:1460-2156
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Small fibres in the skin are vulnerable to damage in metabolic or toxic conditions such as diabetes mellitus or chemotherapy resulting in small fibre neuropathy and associated neuropathic pain. Whether injury to the most distal portion of sensory small fibres due to a primary dermatological disorder can cause neuropathic pain is still unclear. Recessive dystrophic epidermolysis bullosa (RDEB) is a rare condition in which mutations of proteins of the dermo-epidermal junction lead to cycles of blistering followed by regeneration of the skin. Damage is exclusive to the skin and mucous membranes, with no known direct compromise of the nervous system. It is increasingly recognized that most RDEB patients experience daily pain, the aetiology of which is unclear but may include inflammation (in the wounds), musculoskeletal (due to atrophy and retraction scars limiting movement) or neuropathic pain. In this study we investigated the incidence of neuropathic pain and examined the presence of nerve dysfunction in RDEB patients. Around three quarters of patients presented with pain of neuropathic characteristics, which had a length-dependent distribution. Quantitative sensory testing of the foot revealed striking impairments in thermal detection thresholds combined with an increased mechanical pain sensitivity and wind up ratio (temporal summation of noxious mechanical stimuli). Nerve conduction studies showed normal large fibre sensory and motor nerve conduction; however, skin biopsy showed a significant decrease in intraepidermal nerve fibre density. Autonomic nervous system testing revealed no abnormalities in heart rate and blood pressure variability however the sympathetic skin response of the foot was impaired and sweat gland innervation was reduced. We conclude that chronic cutaneous injury can lead to injury and dysfunction of the most distal part of small sensory fibres in a length-dependent distribution resulting in disabling neuropathic pain. These findings also support the use of neuropathic pain screening tools in these patients and treatment algorithms designed to target neuropathic pain.
[Mh] Termos MeSH primário: Epidermólise Bolhosa Distrófica/fisiopatologia
Hiperalgesia/fisiopatologia
Neuralgia/etiologia
Neuropatia de Pequenas Fibras/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Pressão Sanguínea/fisiologia
Estudos de Casos e Controles
Chile/epidemiologia
Epidermólise Bolhosa Distrófica/complicações
Epidermólise Bolhosa Distrófica/patologia
Feminino
Resposta Galvânica da Pele/fisiologia
Frequência Cardíaca
Seres Humanos
Hiperalgesia/complicações
Incidência
Masculino
Fibras Nervosas/patologia
Fibras Nervosas/fisiologia
Condução Nervosa/fisiologia
Neuralgia/complicações
Neuralgia/epidemiologia
Limiar Sensorial
Pele/patologia
Pele/fisiopatologia
Neuropatia de Pequenas Fibras/complicações
Neuropatia de Pequenas Fibras/patologia
Manobra de Valsalva/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE
[do] DOI:10.1093/brain/awx069


  7 / 30 MEDLINE  
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[PMID]:28339448
[Au] Autor:Maino P; Koetsier E; Kaelin-Lang A; Gobbi C; Perez R
[Ad] Endereço:Ospedale Regionale di Lugano, Viganello, Switzerland.
[Ti] Título:Efficacious Dorsal Root Ganglion Stimulation for Painful Small Fiber Neuropathy: A Case Report.
[So] Source:Pain Physician;20(3):E459-E463, 2017 Mar.
[Is] ISSN:2150-1149
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Small fiber neuropathy is a disorder of the peripheral nerves with typical symptoms of burning, sharp, and shooting pain and sensory disturbances in the feet. Pain treatment depends principally on the underlying etiology with concurrent administration of antidepressants, anticonvulsants, opioids, and topical treatments like capsaicin and local anesthetics. However, treatments for pain relief in these patients frequently fail. We describe the first case of intractable painful small fiber neuropathy of the foot successfully treated with spinal cord stimulation of the left L5 dorsal root ganglion.A 74-year-old man presented at our clinic with severe intractable pain, dysesthesia, and allodynia of the left foot caused by idiopathic small fiber neuropathy, confirmed by skin biopsy. His pain score was 8 on a standard 0 - 10 numeric rating scale. As the pain was not satisfactorily controlled by conventional therapy, dorsal root ganglion stimulation was proposed to the patient and, after informed consent, a specifically designed percutaneous stimulation lead was placed over the left L5 dorsal root ganglion and connected to an external neurostimulator. After a positive trial of 10 days, a permanent neurostimulator was implanted. Twenty months post-implantation the patient continued to experience stimulation-induced paresthesia covering the entire pain area and reported a pain rating of 4.Results from the case report demonstrate that the dorsal root ganglion is a promising neural stimulation target to treat neuropathic pain due to intractable small fiber neuropathy. Prospective controlled studies are warranted to confirm the efficacy of this treatment as an option for the aforementioned condition.Key words: Dorsal root ganglion stimulation, small fiber neuropathy, neuropathic pain.
[Mh] Termos MeSH primário: Gânglios Espinais
Neuralgia/terapia
Neuropatia de Pequenas Fibras/terapia
Estimulação da Medula Espinal
[Mh] Termos MeSH secundário: Idoso
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE


  8 / 30 MEDLINE  
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[PMID]:28301890
[Au] Autor:Koch S; Moshourab R; Wollersheim T; Spies C; Fritzsche T; Weber-Carstens S
[Ti] Título:Kasuistik: Late-onset Small-Fiber-Neuropathie nach kritischer Erkrankung..
[So] Source:Anasthesiol Intensivmed Notfallmed Schmerzther;52(3):220-226, 2017 Mar.
[Is] ISSN:1439-1074
[Cp] País de publicação:Germany
[La] Idioma:ger
[Ab] Resumo:A 42-year-old patient presented with acute allodynia and hyperalgesia in her distal limbs, most severe in the innervation area of the ulnar nerve. The patient developed critical illness myopathy/polyneuropathy after septic shock 5 months prior to her presentation. After exclusion of differential diagnosis, "late onset small fiber neuropathy" after critical illness was diagnosed. Recent studies showed small fiber lesions during critical illness and in follow-up exams, where additionally neuropathic pain were proved. Dysfunction of voltage-gated Sodium channels related to severe insulin resistance during critical illness might explain the pathophysiology, as seen in critical illness myopathy/polyneuropathy. Therefore we recommend cooling, pharmacotherapy with carbamazepin/oxcarbazepine, tricyclic antidepressive agents and peripheral nerve blocks to treat patients with "late onset small fiber neuropathy" after critical illness.
[Mh] Termos MeSH primário: Polineuropatias/complicações
Sepse/complicações
Sepse/diagnóstico
Neuropatia de Pequenas Fibras/etiologia
Neuropatia de Pequenas Fibras/terapia
[Mh] Termos MeSH secundário: Adulto
Analgésicos não Entorpecentes/administração & dosagem
Anestésicos Locais/administração & dosagem
Antidepressivos Tricíclicos/administração & dosagem
Terapia Combinada/métodos
Estado Terminal
Feminino
Seres Humanos
Hipotermia Induzida/métodos
Polineuropatias/diagnóstico
Polineuropatias/terapia
Sepse/terapia
Neuropatia de Pequenas Fibras/diagnóstico
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Non-Narcotic); 0 (Anesthetics, Local); 0 (Antidepressive Agents, Tricyclic)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.1055/s-0043-102813


  9 / 30 MEDLINE  
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[PMID]:28221302
[Au] Autor:Blackmore D; Siddiqi ZA
[Ad] Endereço:Department of Neurology, University of Alberta Hospital, Edmonton, AB, Canada. The authors report no conflicts of interest.
[Ti] Título:Diagnostic Criteria for Small Fiber Neuropathy.
[So] Source:J Clin Neuromuscul Dis;18(3):125-131, 2017 Mar.
[Is] ISSN:1537-1611
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Despite its relative common occurrence, definitive diagnosis of small fiber neuropathy (SFN) remains problematic. In practice, patients with pain, numbness, and/or paresthesias in their lower limbs are diagnosed with SFN if found to have dissociated sensory loss in their feet, that is, impaired pinprick perception (PP) but relatively preserved vibration. We sought to assess the sensitivity and specificity of clinical examination and various diagnostic tools available for screening SFN. METHODS: Medical records of 56 patients diagnosed with SFN were reviewed. Diagnosis was based on symptoms, detailed neurological examination that included PP, and abnormal results on at least one testing modality-quantitative sudomotor axon reflex (sweat) test (QSART), quantitative sensory testing (QST), and heart rate variability (HRV) testing. RESULTS: Sensitivity of PP was relatively consistent between modalities of about 63% in presence of appropriate sensory symptoms. Laboratory testing diagnosed 88% of patients when both QSART and QST are employed. QST was most sensitive for detection of SFN with the heat-pain testing having higher sensitivity than cooling. Heart rate variability testing revealed low correlation across all groups. CONCLUSIONS: The diagnostic yield for SFN increases by combining clinical features with various testing modalities. In symptomatic patients, we propose the following diagnostic criteria for diagnosis of SFN: Definite SFN-abnormal neurological examination and both QSART and QST; Probable SFN-abnormal neurological examination, and either QSART or QST; Possible SFN-abnormal neurological exam, QSART, or QST.
[Mh] Termos MeSH primário: Axônios/fisiologia
Eletrodiagnóstico/métodos
Condução Nervosa/fisiologia
Reflexo/fisiologia
Neuropatia de Pequenas Fibras/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Meia-Idade
Exame Neurológico
Estudos Retrospectivos
Sensibilidade e Especificidade
Neuropatia de Pequenas Fibras/fisiopatologia
Vibração
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170222
[St] Status:MEDLINE
[do] DOI:10.1097/CND.0000000000000154


  10 / 30 MEDLINE  
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[PMID]:27743736
[Au] Autor:Laverdet B; Girard D; Bayout A; Bordeau N; Demiot C; Desmoulière A
[Ad] Endereço:University of Limoges, EA 6309 "Myelin maintenance and peripheral neuropathies", Limoges F-87000, France. Electronic address: betty.laverdet@unilim.fr.
[Ti] Título:Effects of small-fiber neuropathy induced by resiniferatoxin on skin healing and axonal regrowth after burn.
[So] Source:Burns;43(3):562-572, 2017 May.
[Is] ISSN:1879-1409
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Damage to the peripheral nervous system influences wound healing and, after a deep burn, imperfect cutaneous nerve regeneration occurs. A third-degree burn model was developed in rats combined with the use of resiniferatoxin (RTX), known to promote sensory neuropathy. METHODS: Rats were injected intraperitoneally either with RTX or vehicle. A mechanical sensory assay and the hot plate thermal sensory test were performed. The structural integrity of the sciatic nerve was assessed using transmission electron microcopy. After RTX injection, third-degree thermal burns were performed. Wound closure was monitored and samples were collected for histological analysis, immunohistochemistry and immunoblotting for neuronal markers. RESULTS: RTX promoted both mechanical and thermal hypoalgesia. This transient RTX-mediated sensory deficit occurred without damaging the integrity of nerve fibers and induced a significant depletion of neuropeptides in both neuronal bodies and intraepidermal nerve fibers. Although wound closure rates were similar in both groups, the kinetic of granulation tissue remodeling was delayed in the RTX group compared with control group. A significant reduction of the peripherin expression in the RTX group was observed indicating impaired axonal regrowth of small fibers within the wound. CONCLUSION: Our study confirms the important roles of innervation during skin healing and the defect of nerve regeneration after burn.
[Mh] Termos MeSH primário: Queimaduras/fisiopatologia
Tecido de Granulação/fisiopatologia
Regeneração Nervosa/fisiologia
Crescimento Neuronal/fisiologia
Nervo Isquiático/fisiopatologia
Neuropatia de Pequenas Fibras/fisiopatologia
Cicatrização/fisiologia
[Mh] Termos MeSH secundário: Animais
Queimaduras/complicações
Diterpenos/toxicidade
Gânglios Espinais/patologia
Gânglios Espinais/fisiopatologia
Immunoblotting
Imuno-Histoquímica
Masculino
Microscopia Eletrônica de Transmissão
Nociceptividade
Ratos
Ratos Sprague-Dawley
Nervo Isquiático/ultraestrutura
Neuropatia de Pequenas Fibras/induzido quimicamente
Neuropatia de Pequenas Fibras/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diterpenes); A5O6P1UL4I (resiniferatoxin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde