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[PMID]:29446282
[Au] Autor:Bodienkova GM; Rukavishnikov VS; Boklazhenko EV
[Ti] Título:[The evaluation of immunoregulatory markers in the course of neurointoxication by mercury over the post-exposure period].
[So] Source:Gig Sanit;95(12):1138-41, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:There was executed the examination of patients with occupational chronic mercury intoxication in the post-exposure period after the exposure to metallic mercury vapor. 47 persons with an established diagnosis of chronic mercury intoxication (HMI) passed the laboratory and immunological examination in the period of exposure to metallic mercury vapor in a production environment. The average age of men accounted for 49.2±1.2 years. The experience of work in hazardous working conditions amounted of 21.65±1.61 years (1 observation). All these same cases were observed in the institute clinic again after 5 years (2 observation) and 10 years (3 observation). A control group of healthy men consisted of 47 cases included persons of representative both age and general work experience, without a professional route of contact with hazardous substances. The level of such cytokines as IL-1ß, IL-2, IL-4, IL-6, TNF-a, INF-y and neurotropic IgG class antibodies directed to proteins of the nervous tissue (NF-200, GFAP, MBP, B-dependent Ca-channel, Glu-R, DA-R, R-GABA, Ser-R, R-Chol, DNA, B2GP) in serum were determined by enzyme linked immunosorbent assay. There was established the gain in the imbalance of inflammatory mediators and production ofneural antibodies in dynamics after the termination of the production in conditions of metallic mercury vapors. Revealed features of the regulatory relationship between the level of cytokines and the severity of the autoimmune process were shown to contribute to the maintenance and progression of neurodegenerative processes. There was recommended the identification of immunoregulatory markers (IL-1ß, IL-4, TNF-a, NF-AT to 200, GFAP, S-100) as an additional criteria for the diagnosis of health disorders in operating and monitoring the course of the progredient professional mercury intoxication.
[Mh] Termos MeSH primário: Citocinas
Intoxicação do Sistema Nervoso por Mercúrio
Mercúrio
Doenças Profissionais
[Mh] Termos MeSH secundário: Formação de Anticorpos/efeitos dos fármacos
Biomarcadores/análise
Biomarcadores/sangue
Indústria Química/métodos
Indústria Química/normas
Citocinas/análise
Citocinas/sangue
Seguimentos
Seres Humanos
Masculino
Mercúrio/imunologia
Mercúrio/toxicidade
Intoxicação do Sistema Nervoso por Mercúrio/diagnóstico
Intoxicação do Sistema Nervoso por Mercúrio/imunologia
Intoxicação do Sistema Nervoso por Mercúrio/prevenção & controle
Meia-Idade
Doenças Profissionais/diagnóstico
Doenças Profissionais/etiologia
Doenças Profissionais/imunologia
Doenças Profissionais/prevenção & controle
Saúde do Trabalhador/normas
Saúde do Trabalhador/estatística & dados numéricos
Sibéria/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Cytokines); FXS1BY2PGL (Mercury)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180216
[St] Status:MEDLINE


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[PMID]:28931792
[Au] Autor:Sakamoto M; Itai T; Murata K
[Ad] Endereço:Department of International Affairs and Environmental Research, National Institute for Minamata Disease.
[Ti] Título:Effects of Prenatal Methylmercury Exposure: From Minamata Disease to Environmental Health Studies.
[So] Source:Nihon Eiseigaku Zasshi;72(3):140-148, 2017.
[Is] ISSN:1882-6482
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Methylmercury, the causative agent of Minamata disease, can easily penetrate the brain, and adult-type Minamata disease patients showed neurological symptoms according to the brain regions where the neurons, mainly in the cerebrum and cerebellum, were damaged. In addition, fetuses are exposed to methylmercury via the placenta from maternal fish consumption, and high-level exposure to methylmercury causes damage to the brains of infants. Typical patients with fetal-type Minamata disease (i.e., serious poisoning caused by in utero exposure to methylmercury) were born during the period of severe methylmercury pollution in 1955-1959, although they showed no abnormality during gestation nor at delivery. However, they showed difficulties in head control, sitting, and walking, and showed disturbances in mental development, these symptoms that are similar to those of cerebral palsy, during the growth periods after birth. The impaired development of fetal-type Minamata disease patients was one of the most tragic and characteristic feature of Minamata disease. In this review, we first summarize 1) the effects of prenatal methylmercury exposure in Minamata disease. Then, we introduce the studies that were conducted mainly by Sakamoto et al. as follows: 2) a retrospective study on temporal and regional variations of methylmercury pollution in Minamata area using preserved umbilical cord methylmercury, 3) decline in male sex ratio observed in Minamata area, 4) characteristics of hand tremor and postural sway in fetal-type Minamata disease patients, 5) methylmercury transfer from mothers to infants during gestation and lactation (the role of placenta), 6) extrapolation studies using rat models on the effects of prenatal methylmercury exposure on the human brain, and 7) risks and benefits of fish consumption.
[Mh] Termos MeSH primário: Doenças Fetais/etiologia
Exposição Materna/efeitos adversos
Intoxicação do Sistema Nervoso por Mercúrio/etiologia
Compostos de Metilmercúrio/efeitos adversos
Compostos de Metilmercúrio/envenenamento
Efeitos Tardios da Exposição Pré-Natal
[Mh] Termos MeSH secundário: Animais
Encéfalo/metabolismo
Modelos Animais de Doenças
Feminino
Peixes
Seres Humanos
Japão
Troca Materno-Fetal
Intoxicação do Sistema Nervoso por Mercúrio/metabolismo
Compostos de Metilmercúrio/metabolismo
Placenta/metabolismo
Gravidez
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Methylmercury Compounds)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1265/jjh.72.140


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[PMID]:28594236
[Au] Autor:O'Malley GF
[Ad] Endereço:a Emergency Medicine , Sidney Kimmel School of Medicine of Thomas Jefferson University Hospital , Philadelphia , PA , USA.
[Ti] Título:The blood of my veins - mercury, Minamata and the soul of Japan.
[So] Source:Clin Toxicol (Phila);55(8):934-938, 2017 Sep.
[Is] ISSN:1556-9519
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The methylmercury contamination of Minamata Bay during the WWII postwar period resulted in thousands of Japanese citizens suffering horrific neurological injury. Fear and miscommunication destroyed and changed family and social structure. In addition, the Minamata poisoning caused momentous changes in the civic discourse in Japan and was an instrumental event in the democratization of the country. This manuscript describes the effects that the environmental contamination and human poising had in the transition of Japan from a feudal society to a democratic one.
[Mh] Termos MeSH primário: Indústria Química
Exposição Ambiental/efeitos adversos
Intoxicação do Sistema Nervoso por Mercúrio/epidemiologia
Compostos de Metilmercúrio/envenenamento
Sistema Nervoso/efeitos dos fármacos
Poluentes Químicos da Água/envenenamento
[Mh] Termos MeSH secundário: Indústria Química/história
Indústria Química/legislação & jurisprudência
Democracia
Exposição Ambiental/história
Monitoramento Ambiental
História do Século XX
Seres Humanos
Japão/epidemiologia
Intoxicação do Sistema Nervoso por Mercúrio/diagnóstico
Intoxicação do Sistema Nervoso por Mercúrio/história
Intoxicação do Sistema Nervoso por Mercúrio/fisiopatologia
Compostos de Metilmercúrio/história
Sistema Nervoso/fisiopatologia
Formulação de Políticas
Prognóstico
Política Pública
Fatores de Tempo
Poluentes Químicos da Água/história
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Methylmercury Compounds); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.1080/15563650.2017.1326606


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[PMID]:28366955
[Au] Autor:Bose-O'Reilly S; Bernaudat L; Siebert U; Roider G; Nowak D; Drasch G
[Ad] Endereço:University Hospital Munich, Munich, Germany (Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, WHO Collaborating Centre for Occupational Health). stephan.boeseoreilly@med.uni-muenchen.de.
[Ti] Título:Signs and symptoms of mercury-exposed gold miners.
[So] Source:Int J Occup Med Environ Health;30(2):249-269, 2017 Mar 30.
[Is] ISSN:1896-494X
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Gold miners use mercury to extract gold from ore adding liquid mercury to the milled gold-containing ore. This results in a mercury-gold compound, called amalgam. Miners smelt this amalgam to obtain gold, vaporizing it and finally inhaling the toxic mercury fumes. The objective was to merge and analyze data from different projects, to identify typical signs and symptoms of chronic inorganic mercury exposure. MATERIAL AND METHODS: Miners and community members from various artisanal small-scale gold mining areas had been examined (Philippines, Mongolia, Tanzania, Zimbabwe, Indonesia). Data of several health assessments were pooled. Urine, blood and hair samples were analyzed for mercury (N = 1252). Questionnaires, standardized medical examinations and neuropsychological tests were used. Participants were grouped into: Controls (N = 209), living in an exposed area (N = 408), working with mercury as panners (N = 181), working with mercury as amalgam burners (N = 454). Chi2 test, linear trend test, Mann-Whitney test, Kruskal-Wallis test, correlation coefficient, Spearman's rho, and analysis of variance tests were used. An algorithm was used to define participants with chronic mercury intoxication. RESULTS: Mean mercury concentrations in all exposed subgroups were elevated and above threshold limits, with amalgam burners showing highest levels. Typical symptoms of chronic metallic mercury intoxication were tremor, ataxia, coordination problems, excessive salivation and metallic taste. Participants from the exposed groups showed poorer results in different neuropsychological tests in comparison to the control group. Fifty-four percent of the high-exposed group (amalgam burners) were diagnosed as being mercury-intoxicated, compared to 0% within the control group (Chi2 p < 0.001). CONCLUSIONS: Chronic mercury intoxication, with tremor, ataxia and other neurological symptoms together with a raised body burden of mercury was clinically diagnosed in exposed people in artisanal small-scale mining areas. The mercury exposure needs to be urgently reduced. Health care systems need to be prepared for this emerging problem of chronic mercury intoxication among exposed people. Int J Occup Med Environ Health 2017;30(2):249-269.
[Mh] Termos MeSH primário: Ouro
Intoxicação do Sistema Nervoso por Mercúrio/epidemiologia
Mercúrio/sangue
Mercúrio/urina
Mineradores
[Mh] Termos MeSH secundário: Ataxia/induzido quimicamente
Carga Corporal (Radioterapia)
Feminino
Cabelo/química
Seres Humanos
Masculino
Metalurgia
Testes Neuropsicológicos
Exposição Ocupacional
Tremor/induzido quimicamente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
7440-57-5 (Gold); FXS1BY2PGL (Mercury)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE


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[PMID]:28267559
[Au] Autor:Fujimura M; Usuki F
[Ad] Endereço:Department of Basic Medical Sciences, National Institute for Minamata Disease, 4058-18 Hama, Minamata, Kumamoto 867-0008, Japan. Electronic address: fujimura@nimd.go.jp.
[Ti] Título:Site-specific neural hyperactivity via the activation of MAPK and PKA/CREB pathways triggers neuronal degeneration in methylmercury-intoxicated mice.
[So] Source:Toxicol Lett;271:66-73, 2017 Apr 05.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Methylmercury (MeHg) induces site-specific neurotoxicity in the adult brain. In this study, we investigated the site-specific expression of the signaling cascade related to neural activity in a mouse model of MeHg intoxication showing neurodegeneration only in the deep layer of the cerebral cortex, especially layer IV. We performed time course studies of c-fos and brain-derived neurotrophic factor (BDNF) expression levels which are proper markers of neural activity. We showed that upregulation of both markers preceded the neuronal degeneration in the cerebral cortex. Immunohistochemical analysis revealed the site-specific upregulation of c-fos in the deep layer of the cerebral cortex. Western blot analysis showed that c-fos and BDNF expression was associated with CREB phosphorylation, which was triggered by the activation of the p44/42 MAPK, p38 MAPK and PKA pathways. However, we did not detect any changes in the expression levels of c-fos and BDNF proteins and no signs of neuronal degeneration in the hippocampus and cerebellum, despite the fact that we could detect accumulation of MeHg in these two brain regions. These results suggested an intriguing possibility that MeHg-induced neuronal degeneration was caused by site-specific neural hyperactivity triggered by the activation of MAPK and PKA/CREB pathways followed by c-fos and BDNF upregulation.
[Mh] Termos MeSH primário: Córtex Cerebral/efeitos dos fármacos
Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/metabolismo
Proteínas Quinases Dependentes de AMP Cíclico/metabolismo
Intoxicação do Sistema Nervoso por Mercúrio/prevenção & controle
Compostos de Metilmercúrio
Proteínas Quinases Ativadas por Mitógeno/metabolismo
Degeneração Neural
Neurônios/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Western Blotting
Fator Neurotrófico Derivado do Encéfalo/metabolismo
Córtex Cerebral/enzimologia
Córtex Cerebral/patologia
Córtex Cerebral/fisiopatologia
Modelos Animais de Doenças
Ativação Enzimática
Imuno-Histoquímica
Masculino
Intoxicação do Sistema Nervoso por Mercúrio/enzimologia
Intoxicação do Sistema Nervoso por Mercúrio/patologia
Intoxicação do Sistema Nervoso por Mercúrio/fisiopatologia
Camundongos Endogâmicos ICR
Neurônios/enzimologia
Neurônios/patologia
Fosforilação
Proteínas Proto-Oncogênicas c-fos/metabolismo
Transdução de Sinais
Fatores de Tempo
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Brain-Derived Neurotrophic Factor); 0 (Creb1 protein, mouse); 0 (Cyclic AMP Response Element-Binding Protein); 0 (Methylmercury Compounds); 0 (Proto-Oncogene Proteins c-fos); EC 2.7.11.11 (Cyclic AMP-Dependent Protein Kinases); EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170328
[Lr] Data última revisão:
170328
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE


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[PMID]:28118383
[Au] Autor:Takahashi T; Fujimura M; Koyama M; Kanazawa M; Usuki F; Nishizawa M; Shimohata T
[Ad] Endereço:Department of Neurology, Brain Research Institute, Niigata University, Niigata, Niigata, Japan.
[Ti] Título:Methylmercury Causes Blood-Brain Barrier Damage in Rats via Upregulation of Vascular Endothelial Growth Factor Expression.
[So] Source:PLoS One;12(1):e0170623, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Clinical manifestations of methylmercury (MeHg) intoxication include cerebellar ataxia, concentric constriction of visual fields, and sensory and auditory disturbances. The symptoms depend on the site of MeHg damage, such as the cerebellum and occipital lobes. However, the underlying mechanism of MeHg-induced tissue vulnerability remains to be elucidated. In the present study, we used a rat model of subacute MeHg intoxication to investigate possible MeHg-induced blood-brain barrier (BBB) damage. The model was established by exposing the rats to 20-ppm MeHg for up to 4 weeks; the rats exhibited severe cerebellar pathological changes, although there were no significant differences in mercury content among the different brain regions. BBB damage in the cerebellum after MeHg exposure was confirmed based on extravasation of endogenous immunoglobulin G (IgG) and decreased expression of rat endothelial cell antigen-1. Furthermore, expression of vascular endothelial growth factor (VEGF), a potent angiogenic growth factor, increased markedly in the cerebellum and mildly in the occipital lobe following MeHg exposure. VEGF expression was detected mainly in astrocytes of the BBB. Intravenous administration of anti-VEGF neutralizing antibody mildly reduced the rate of hind-limb crossing signs observed in MeHg-exposed rats. In conclusion, we demonstrated for the first time that MeHg induces BBB damage via upregulation of VEGF expression at the BBB in vivo. Further studies are required in order to determine whether treatment targeted at VEGF can ameliorate MeHg-induced toxicity.
[Mh] Termos MeSH primário: Barreira Hematoencefálica/efeitos dos fármacos
Permeabilidade Capilar/efeitos dos fármacos
Ataxia Cerebelar/induzido quimicamente
Cerebelo/efeitos dos fármacos
Intoxicação do Sistema Nervoso por Mercúrio/genética
Compostos de Metilmercúrio/toxicidade
Fator A de Crescimento do Endotélio Vascular/biossíntese
[Mh] Termos MeSH secundário: Animais
Anticorpos Neutralizantes/uso terapêutico
Astrócitos/efeitos dos fármacos
Astrócitos/metabolismo
Química Encefálica
Ataxia Cerebelar/tratamento farmacológico
Ataxia Cerebelar/fisiopatologia
Cerebelo/metabolismo
Cerebelo/patologia
Masculino
Mercúrio/análise
Intoxicação do Sistema Nervoso por Mercúrio/metabolismo
Intoxicação do Sistema Nervoso por Mercúrio/patologia
Compostos de Metilmercúrio/farmacologia
Lobo Occipital/efeitos dos fármacos
Lobo Occipital/metabolismo
Lobo Occipital/patologia
Ratos
Ratos Wistar
Fatores de Tempo
Regulação para Cima/efeitos dos fármacos
Fator A de Crescimento do Endotélio Vascular/antagonistas & inibidores
Fator A de Crescimento do Endotélio Vascular/genética
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Neutralizing); 0 (Methylmercury Compounds); 0 (Vascular Endothelial Growth Factor A); 0 (vascular endothelial growth factor A, rat); FXS1BY2PGL (Mercury)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0170623


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[PMID]:27738246
[Au] Autor:Sallon S; Dory Y; Barghouthy Y; Tamdin T; Sangmo R; Tashi J; Yangdon S; Yeshi T; Sadutshang T; Rotenberg M; Cohen E; Harlavan Y; Sharabi G; Bdolah-Abram T
[Ad] Endereço:1 The Louis L Borick Natural Medicine Research Center, Hadassah Medical Organization, Jerusalem 91120, Israel.
[Ti] Título:Is mercury in Tibetan Medicine toxic? Clinical, neurocognitive and biochemical results of an initial cross-sectional study.
[So] Source:Exp Biol Med (Maywood);242(3):316-332, 2017 Feb.
[Is] ISSN:1535-3699
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mercury an important therapeutic substance in Tibetan Medicine undergoes complex "detoxification" prior to inclusion in multi-ingredient formulas. In an initial cross-sectional study, patients taking Tibetan Medicine for various conditions were evaluated for mercury toxicity. Two groups were identified: Group 1, patients taking " Tsothel" the most important detoxified mercury preparation and Group 2, patients taking other mercury preparations or mercury free Tibetan Medicine. Atomic fluorescence spectrometry of Tibetan Medicine showed mercury consumption 130 µg/kg/day (Group 1) and 30 µg/kg/day (Group 2) ( P ≤ 0.001), levels above EPA (RfDs) suggested threshold (0.3 µg/kg /day) for oral chronic exposure. Mean duration of Tibetan Medicine treatment was 9 ± 17 months (range 3-116) (Group 1) and 5 ± 1.96 months (range 1-114) (Group 2) (NS) with cumulative days of mercury containing Tibetan Medicine, 764 days ± 1214 (range 135-7330) vs. 103 days ± 111 (range 0-426), respectively ( P ≤ 0.001). Comparison of treatment groups with healthy referents (Group 3) not taking Tibetan Medicine showed no significant differences in prevalence of 23 non-specific symptoms of mercury toxicity, abnormal neurological, cardiovascular and dental findings and no correlation with mercury exposure variables; consumption, cumulative treatment days, blood/ urine Hg. Liver and renal function tests in treatment groups were not significantly increased compared to referents, with mean urine Beta Microglobulin within the normal range and not significantly associated with Hg exposure variables after correcting for confounding variables. Neurocognitive testing showed no significant intergroup differences for Wechsler Memory Scale, Grooved Pegboard, Visual Retention, but Group1 scores were better for Mini-Mental, Brief Word Learning, Verbal Fluency after correcting for confounding variables. These results suggest mercury containing Tibetan Medicine does not have appreciable adverse effects and may exert a possible beneficial effect on neurocognitive function. Since evidence of mercury as a toxic heavy metal, however, is well known, further analysis of literature on mercury use in other Asian traditional systems is highly suggested prior to further studies.
[Mh] Termos MeSH primário: Cognição/efeitos dos fármacos
Medicina Tradicional Tibetana/efeitos adversos
Intoxicação do Sistema Nervoso por Mercúrio/diagnóstico
Mercúrio/toxicidade
Mercúrio/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Estudos Transversais
Feminino
Seres Humanos
Índia
Masculino
Mercúrio/sangue
Mercúrio/urina
Intoxicação do Sistema Nervoso por Mercúrio/sangue
Intoxicação do Sistema Nervoso por Mercúrio/urina
Espectrometria de Fluorescência
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
FXS1BY2PGL (Mercury)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161015
[St] Status:MEDLINE
[do] DOI:10.1177/1535370216672748


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[PMID]:27853104
[Au] Autor:Iwata T; Takaoka S; Sakamoto M; Maeda E; Nakamura M; Liu XJ; Murata K
[Ad] Endereço:Department of Environmental Health Sciences, Akita University Graduate School of Medicine.
[Ti] Título:Characteristics of hand tremor and postural sway in patients with fetal-type Minamata disease.
[So] Source:J Toxicol Sci;41(6):757-763, 2016.
[Is] ISSN:1880-3989
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:About forty certified patients aged around 50 years old existed as living witnesses to fetal-type Minamata disease (methylmercury poisoning due to in utero exposure) in Minamata, Japan in 2006. Computerized hand tremor and postural sway tests with spectral analysis were conducted for 24 of them and in matched control subjects to examine the pathophysiological feature of neuromotor function. The tremor intensities of the patients with fetal-type Minamata disease were significantly larger than those of the 67 controls at every frequency band for both hands. In the patients, proportions for intensity at 1-6 Hz of both hands were larger, but those of the intensity at 6-10 Hz were smaller compared with the controls. The center frequency of a tremor was significantly lower in the patients than in the controls. Only eight males of the 24 patients were examined to evaluate postural sway because of extremely low scores in activities of daily living in the remaining. Most of the postural sway parameters obtained with eyes open and closed were significantly larger in the patients than in the male controls. Likewise, Romberg quotients of postural sway in anterior-posterior direction were significantly higher in the patients. In conclusion, the patients with fetal-type Minamata disease of our study showed a larger tremor of low frequency at less than 6 Hz and postural instability. Spectral analyses of computerized hand tremor and postural sway are suggested to be useful for assessing the pathophysiological change, related to a lesion of the cerebellum, resulting from prenatal methylmercury exposure.
[Mh] Termos MeSH primário: Mãos/inervação
Intoxicação do Sistema Nervoso por Mercúrio/complicações
Compostos de Metilmercúrio/efeitos adversos
Equilíbrio Postural
Efeitos Tardios da Exposição Pré-Natal
Transtornos das Sensações/etiologia
Tremor/etiologia
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Feminino
Seres Humanos
Masculino
Intoxicação do Sistema Nervoso por Mercúrio/classificação
Intoxicação do Sistema Nervoso por Mercúrio/diagnóstico
Intoxicação do Sistema Nervoso por Mercúrio/fisiopatologia
Meia-Idade
Exame Neurológico
Gravidez
Transtornos das Sensações/diagnóstico
Transtornos das Sensações/fisiopatologia
Tremor/diagnóstico
Tremor/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Methylmercury Compounds)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170411
[Lr] Data última revisão:
170411
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161118
[St] Status:MEDLINE


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[PMID]:27554566
[Au] Autor:Fell AK; Eikeland R; Aaseth JO
[Ad] Endereço:Avdeling for arbeidsmedisin Sykehuset Telemark.
[Ti] Título:A woman in her thirties with cough, tremor, agitation and visual disturbances.
[Ti] Título:En kvinne i 30-årene med hoste, tremor, uro og synsforstyrrelser..
[So] Source:Tidsskr Nor Laegeforen;136(14-15):1233-5, 2016 Aug.
[Is] ISSN:0807-7096
[Cp] País de publicação:Norway
[La] Idioma:eng; nor
[Mh] Termos MeSH primário: Amálgama Dentário/efeitos adversos
Intoxicação do Sistema Nervoso por Mercúrio/etiologia
Mercúrio/efeitos adversos
Doenças Profissionais/induzido quimicamente
Exposição Ocupacional/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Idoso
Acatisia Induzida por Medicamentos/etiologia
Tosse/induzido quimicamente
Diagnóstico Tardio
Assistentes de Odontologia
Feminino
Seres Humanos
Meia-Idade
Tremor/induzido quimicamente
Transtornos da Visão/induzido quimicamente
[Pt] Tipo de publicação:CASE REPORTS
[Nm] Nome de substância:
8049-85-2 (Dental Amalgam); FXS1BY2PGL (Mercury)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160825
[St] Status:MEDLINE
[do] DOI:10.4045/tidsskr.15.0998


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[PMID]:27180086
[Au] Autor:Robitaille S; Mailloux RJ; Chan HM
[Ad] Endereço:University of Ottawa, Department of Biology, Center for Advanced Research in Environmental Genomics, Ottawa K1N 6N5, ON, Canada.
[Ti] Título:Methylmercury alters glutathione homeostasis by inhibiting glutaredoxin 1 and enhancing glutathione biosynthesis in cultured human astrocytoma cells.
[So] Source:Toxicol Lett;256:1-10, 2016 Aug 10.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Methylmercury (MeHg) is a neurotoxin that binds strongly to thiol residues on protein and low molecular weight molecules like reduced glutathione (GSH). The mechanism of its effects on GSH homeostasis particularly at environmentally relevant low doses is not fully known. We hypothesized that exposure to MeHg would lead to a depletion of reduced glutathione (GSH) and an accumulation of glutathione disulfide (GSSG) leading to alterations in S-glutathionylation of proteins. Our results showed exposure to low concentrations of MeHg (1µM) did not significantly alter GSH levels but increased GSSG levels by ∼12-fold. This effect was associated with a significant increase in total cellular glutathione content and a decrease in GSH/GSSG. Immunoblot analyses revealed that proteins involved in glutathione synthesis were upregulated accounting for the increase in cellular glutathione. This was associated an increase in cellular Nrf2 protein levels which is required to induce the expression of antioxidant genes in response to cellular stress. Intriguingly, we noted that a key enzyme involved in reversing protein S-glutathionylation and maintaining glutathione homeostasis, glutaredoxin-1 (Grx1), was inhibited by ∼50%. MeHg treatment also increased the S-glutathionylation of a high molecular weight protein. This observation is consistent with the inhibition of Grx1 and elevated H2O2 production however; contrary to our original hypothesis we found few S-glutathionylated proteins in the astrocytoma cells. Collectively, MeHg affects multiple arms of glutathione homeostasis ranging from pool management to protein S-glutathionylation and Grx1 activity.
[Mh] Termos MeSH primário: Astrocitoma/enzimologia
Neoplasias do Sistema Nervoso Central/enzimologia
Glutarredoxinas/antagonistas & inibidores
Glutationa/biossíntese
Intoxicação do Sistema Nervoso por Mercúrio/enzimologia
Compostos de Metilmercúrio/toxicidade
Neurônios/efeitos dos fármacos
[Mh] Termos MeSH secundário: Astrocitoma/patologia
Linhagem Celular Tumoral
Neoplasias do Sistema Nervoso Central/patologia
Relação Dose-Resposta a Droga
Glutarredoxinas/metabolismo
Dissulfeto de Glutationa
Homeostase
Seres Humanos
Intoxicação do Sistema Nervoso por Mercúrio/metabolismo
Neurônios/enzimologia
Neurônios/patologia
Oxirredução
Estresse Oxidativo/efeitos dos fármacos
Processamento de Proteína Pós-Traducional
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (GLRX protein, human); 0 (Glutaredoxins); 0 (Methylmercury Compounds); GAN16C9B8O (Glutathione); ULW86O013H (Glutathione Disulfide)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170130
[Lr] Data última revisão:
170130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160516
[St] Status:MEDLINE



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