Base de dados : MEDLINE
Pesquisa : C10.886 [Categoria DeCS]
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[PMID]:29431940
[Au] Autor:Novichkova NI; Kallistov DY; Romanova EA; Sobolevskaya OV; Romanov AI
[Ti] Título:[Hygienic analysis of factors affecting of the occurrence of sleep disorders prevalence rate].
[So] Source:Gig Sanit;95(11):1037-40, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Aim: To evaluate the prevalence rate of sleep disorders in various age and professional groups of the population - residents of different regions of Russia and to estimate the relative role of environmental, work-related and life style factors in their progression. Materials and Methods: 6 groups of the population including more than 2500 adults and children - residents of areas with various levels of environmental pollution were examined with the use of the structured questionnaire. Working conditions of state employees and health care professionals were examined. Statistical analysis including the calculation of odds ratios for sleep disorders was performed Results: Disorders of the sleep maintenance among adults were found in 49% of men and 51% of women in Moscow; 49.3% of men and 26.7% of women in Voronezh. Air pollution and noise levels increased risks of insomnia by 10% and 20% respectively. In the city of Serpukhov (the Moscow Region) 78.7% of girls and 94.1% of boys estimated their sleep as deep and sound; in the Great Novgorod so did 69.2% girls and 66.0% boys. A trend (R=0.97) for the increasing of the prevalence rate of insomnia symptoms among children with the age was revealed. In working populations there was shown the positive correlation between the prevalence rate of sleep disorders and job environment, hardness of the work (r=0.28) and work-related stress (odds ratio = 1.8). Conclusion: Harmful environmental factors, life style, hardness of the work and work related stress are independent risk factors of chronic insomnia.
[Mh] Termos MeSH primário: Exposição Ambiental
Estilo de Vida
Estresse Ocupacional
Transtornos do Sono-Vigília
[Mh] Termos MeSH secundário: Adulto
Criança
Exposição Ambiental/efeitos adversos
Exposição Ambiental/análise
Exposição Ambiental/prevenção & controle
Feminino
Seres Humanos
Masculino
Estresse Ocupacional/complicações
Estresse Ocupacional/epidemiologia
Estresse Ocupacional/prevenção & controle
Prevalência
Saúde Pública/métodos
Saúde Pública/estatística & dados numéricos
Federação Russa/epidemiologia
Transtornos do Sono-Vigília/epidemiologia
Transtornos do Sono-Vigília/etiologia
Transtornos do Sono-Vigília/prevenção & controle
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


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[PMID]:29406641
[Au] Autor:Celia T; Freysteinson WW; Frye RE
[Ti] Título:Concurrent Medical Conditions in Autism Spectrum Disorders.
[So] Source:Pediatr Nurs;42(5):230-4, 2016 Sep-Oct.
[Is] ISSN:0097-9805
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Long thought to be purely psychological in origin, current research lends credenceto the idea that autism has a medical basis. Patients with autism can be among themost challenging patients that a healthcare provider may care for. Often the presentingsymptoms of autism make these patients difficult to examine and may alsomask underlying concurrent conditions. This article reviews some of the more commonconditions found concurrently in the autistic population.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista/complicações
Transtorno do Espectro Autista/diagnóstico
Gastroenteropatias/etiologia
Doenças do Sistema Imune/etnologia
Doenças do Sistema Nervoso/etiologia
Transtornos do Sono-Vigília/etiologia
[Mh] Termos MeSH secundário: Adolescente
Transtorno do Espectro Autista/epidemiologia
Transtorno do Espectro Autista/fisiopatologia
Criança
Pré-Escolar
Comorbidade
Feminino
Gastroenteropatias/epidemiologia
Gastroenteropatias/terapia
Seres Humanos
Doenças do Sistema Imune/epidemiologia
Doenças do Sistema Imune/terapia
Lactente
Masculino
Doenças do Sistema Nervoso/epidemiologia
Doenças do Sistema Nervoso/terapia
Transtornos do Sono-Vigília/epidemiologia
Transtornos do Sono-Vigília/terapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:29406628
[Au] Autor:Cavalieri A
[Ti] Título:Sleep Issues in Children with AutismSpectrum Disorder.
[So] Source:Pediatr Nurs;42(4):169-74, 2016 Jul-Aug.
[Is] ISSN:0097-9805
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sleep issues are more prevalent in children with autism spectrum disorder (ASD)than in typically developing children. Parents often seek help from providers toimprove their child's ability to fall asleep, stay asleep longer, and decrease awakeningsthrough the night. The pathophysiology of ASD, as well as sleep issuesin children with ASD, are not well understood, which poses certain difficulties inchoosing the most effective and appropriate treatment options. This article discussesprobable causes of sleep problems in children with ASD, existing treatments,and implications for clinical practice and future research.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista/complicações
Transtorno do Espectro Autista/terapia
Transtornos do Sono-Vigília/etiologia
Transtornos do Sono-Vigília/terapia
[Mh] Termos MeSH secundário: Adolescente
Transtorno do Espectro Autista/fisiopatologia
Criança
Seres Humanos
Prevalência
Transtornos do Sono-Vigília/fisiopatologia
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:29385179
[Au] Autor:Theadom A; Starkey N; Barker-Collo S; Jones K; Ameratunga S; Feigin V; BIONIC4you Research Group
[Ad] Endereço:National Institute for Stroke and Applied Neuroscience, Auckland University of Technology, Auckland, New Zealand.
[Ti] Título:Population-based cohort study of the impacts of mild traumatic brain injury in adults four years post-injury.
[So] Source:PLoS One;13(1):e0191655, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There is increasing evidence that some people can experience persistent symptoms for up to a year following mild TBI. However, few longitudinal studies of mild TBI exist and the longer-term impact remains unclear. The purpose of this study is to determine if there are long-term effects of mild traumatic brain injury (TBI) four-years later. Adults (aged ≥16 years) identified as part of a TBI incidence study who experienced a mild-TBI four-years ago (N = 232) were compared to age-sex matched controls (N = 232). Sociodemographic variables, prior TBI and symptoms were assessed at the time of injury. Four years post-injury participants completed the Rivermead Post-Concussion Symptom Questionnaire, Hospital Anxiety and Depression Scale, Pittsburgh Sleep Quality Index and the Participation Assessment with Recombined Tools. Analysis of covariance was used to compare differences between TBI cases four years post-injury and controls, controlling for prior TBI and depression. A multiple regression model was used to identify the predictors of increased symptoms and reduced participation. The mild-TBI sample experienced significantly increased self-reported cognitive symptoms (F = 19.90, p = <0.01) four years post-injury than controls. There were no differences between the groups for somatic (F = 0.02, p = 0.89) or emotional symptoms (F = 0.31, p = 0.58). Additionally, the mild-TBI group reported significantly poorer community participation across all three domains: productivity (F = 199.07, p = <0.00), social relations (F = 13.93, p = <0.00) and getting out and about (F = 364.69, p = <0.00) compared to controls. A regression model accounting for 41% of the variance in cognitive symptoms in TBI cases revealed a history of TBI, receiving acute medical attention and baseline cognitive symptoms, sleep quality, anxiety and depression were predictive of outcome. The results indicate that whilst somatic and emotional symptoms resolve over time, cognitive symptoms can become persistent and that mild TBI can impact longer-term community participation. Early intervention is needed to reduce the longer-term impact of cognitive symptoms and facilitate participation.
[Mh] Termos MeSH primário: Lesões Encefálicas Traumáticas/psicologia
[Mh] Termos MeSH secundário: Adulto
Ansiedade/etiologia
Lesões Encefálicas Traumáticas/complicações
Estudos de Casos e Controles
Disfunção Cognitiva/etiologia
Estudos de Coortes
Depressão/etiologia
Feminino
Seres Humanos
Estudos Longitudinais
Masculino
Meia-Idade
Nova Zelândia
Autorrelato
Transtornos do Sono-Vigília/etiologia
Comportamento Social
Inquéritos e Questionários
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191655


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[PMID]:28459898
[Au] Autor:Pek EA; Remfry A; Pendrith C; Fan-Lun C; Bhatia RS; Soong C
[Ad] Endereço:Department of Medicine, University of Toronto, Ontario.
[Ti] Título:High Prevalence of Inappropriate Benzodiazepine and Sedative Hypnotic Prescriptions among Hospitalized Older Adults.
[So] Source:J Hosp Med;12(5):310-316, 2017 May.
[Is] ISSN:1553-5606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Benzodiazepines and sedative hypnotics are commonly used to treat insomnia and agitation in older adults despite significant risk. A clear understanding of the extent of the problem and its contributors is required to implement effective interventions. OBJECTIVE: To determine the proportion of hospitalized older adults who are inappropriately prescribed benzodiazepines or sedative hypnotics, and to identify patient and prescriber factors associated with increased prescriptions. DESIGN: Single-center retrospective observational study. SETTING: Urban academic medical center. PARTICIPANTS: Medical-surgical inpatients aged 65 or older who were newly prescribed a benzodiazepine or zopiclone. MEASUREMENTS: Our primary outcome was the proportion of patients who were prescribed a potentially inappropriate benzodiazepine or sedative hypnotic. Potentially inappropriate indications included new prescriptions for insomnia or agitation/anxiety. We used a multivariable random-intercept logistic regression model to identify patient- and prescriber-level variables that were associated with potentially inappropriate prescriptions. RESULTS: Of 1308 patients, 208 (15.9%) received a potentially inappropriate prescription. The majority of prescriptions, 254 (77.4%), were potentially inappropriate. Of these, most were prescribed for insomnia (222; 87.4%) and during overnight hours (159; 62.3%). Admission to a surgical or specialty service was associated with significantly increased odds of potentially inappropriate prescription compared to the general internal medicine service (odds ratio [OR], 6.61; 95% confidence interval [CI], 2.70-16.17). Prescription by an attending physician or fellow was associated with significantly fewer prescriptions compared to first-year trainees (OR, 0.28; 95% CI, 0.08-0.93). Nighttime prescriptions did not reach significance in initial bivariate analyses but were associated with increased odds of potentially inappropriate prescription in our regression model (OR, 4.48; 95% CI, 2.21-9.06). CONCLUSIONS: The majority of newly prescribed benzodiazepines and sedative hypnotics were potentially inappropriate and were primarily prescribed as sleep aids. Future interventions should focus on the development of safe sleep protocols and education targeted at first-year trainees.Journal of Hospital Medicine 2017;12:310-316.
[Mh] Termos MeSH primário: Benzodiazepinas/uso terapêutico
Hospitalização/tendências
Hipnóticos e Sedativos/uso terapêutico
Prescrição Inadequada/tendências
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Benzodiazepinas/efeitos adversos
Prescrições de Medicamentos
Feminino
Seres Humanos
Hipnóticos e Sedativos/efeitos adversos
Masculino
Prevalência
Estudos Retrospectivos
Transtornos do Sono-Vigília/tratamento farmacológico
Transtornos do Sono-Vigília/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Hypnotics and Sedatives); 12794-10-4 (Benzodiazepines)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.12788/jhm.2739


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[PMID]:29386445
[Au] Autor:Sugiura A; Eto T; Kinoshita F; Takada H
[Ad] Endereço:Department of Radiological Technology, Gifu University of Medical Science.
[Ti] Título:[Effect of Reading a Book on a Tablet Computer on Cerebral Blood Flow in the Prefrontal Cortex].
[So] Source:Nihon Eiseigaku Zasshi;73(1):39-45, 2018.
[Is] ISSN:1882-6482
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:OBJECTIVES: By measuring cerebral blood flow in the prefrontal cortex, we aimed to determine how reading a book on a tablet computer affects sleep. METHODS: Seven students (7 men age range, 21-32 years) participated in this study. In a controlled illuminance environment, the subjects read a novel in printed form or on a tablet computer from any distance. As the subjects were reading, the cerebral blood flow in their prefrontal cortex was measured by near-infrared spectroscopy. The study protocol was as follows. 1) Subjects mentally counted a sequence of numbers for 30 s as a pretest to standardized thinking and then 2) read the novel for 10 min, using the printed book or tablet computer. In step 2), the use of the book or tablet computer was in a random sequence. Subjects rested between the two tasks. RESULTS: Significantly increased brain activity (increase in regional cerebral blood flow) was observed following reading a novel on a tablet computer compared with that after reading a printed book. Furthermore, the region around Broca's area was more active when reading on a tablet computer than when reading a printed book. CONCLUSIONS: Considering the results of this study and previous studies on physiological characteristics during nonrapid eye movement sleep, we concluded that reading a book on a tablet computer before the onset of sleep leads to the potential inhibition of sound sleep through mechanisms other than the suppression of melatonin secretion.
[Mh] Termos MeSH primário: Circulação Cerebrovascular/fisiologia
Computadores de Mão
Córtex Pré-Frontal/irrigação sanguínea
Leitura
Transtornos do Sono-Vigília/etiologia
Sono/fisiologia
[Mh] Termos MeSH secundário: Adulto
Livros
Seres Humanos
Masculino
Melatonina/secreção
Espectroscopia de Luz Próxima ao Infravermelho
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
JL5DK93RCL (Melatonin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180202
[St] Status:MEDLINE
[do] DOI:10.1265/jjh.73.39


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[PMID]:29192612
[Au] Autor:Basner M; Clark C; Hansell A; Hileman JI; Janssen S; Shepherd K; Sparrow V
[Ad] Endereço:Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[Ti] Título:Aviation Noise Impacts: State of the Science.
[So] Source:Noise Health;19(87):41-50, 2017 Mar-Apr.
[Is] ISSN:1463-1741
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Noise is defined as "unwanted sound." Aircraft noise is one, if not the most detrimental environmental effect of aviation. It can cause community annoyance, disrupt sleep, adversely affect academic performance of children, and could increase the risk for cardiovascular disease of people living in the vicinity of airports. In some airports, noise constrains air traffic growth. This consensus paper was prepared by the Impacts of Science Group of the Committee for Aviation Environmental Protection of the International Civil Aviation Organization and summarizes the state of the science of noise effects research in the areas of noise measurement and prediction, community annoyance, children's learning, sleep disturbance, and health. It also briefly discusses civilian supersonic aircraft as a future source of aviation noise.
[Mh] Termos MeSH primário: Aeronaves
Aeroportos
Exposição Ambiental/efeitos adversos
Exposição Ambiental/prevenção & controle
Humor Irritável
Transtornos de Aprendizagem/etiologia
Transtornos de Aprendizagem/prevenção & controle
Ruído dos Transportes/efeitos adversos
Ruído dos Transportes/prevenção & controle
Transtornos do Sono-Vigília/etiologia
Transtornos do Sono-Vigília/prevenção & controle
[Mh] Termos MeSH secundário: Guias como Assunto
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.4103/nah.NAH_104_16


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[PMID]:29192613
[Au] Autor:Prendergast GP; Staff M
[Ad] Endereço:Northern Sydney Public Health Unit, Hornsby, NSW, Australia.
[Ti] Título:A Health-Based Metric for Evaluating the Effectiveness of Noise Barrier Mitigation Associated With Transport Infrastructure Noise.
[So] Source:Noise Health;19(87):51-57, 2017 Mar-Apr.
[Is] ISSN:1463-1741
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: This study examines the use of the number of night-time sleep disturbances as a health-based metric to assess the cost effectiveness of rail noise mitigation strategies for situations, wherein high-intensity noises dominate such as freight train pass-bys and wheel squeal. MATERIALS AND METHODS: Twenty residential properties adjacent to the existing and proposed rail tracks in a noise catchment area of the Epping to Thornleigh Third Track project were used as a case study. Awakening probabilities were calculated for individual's awakening 1, 3 and 5 times a night when subjected to 10 independent freight train pass-by noise events using internal maximum sound pressure levels (LAFmax). RESULTS: Awakenings were predicted using a random intercept multivariate logistic regression model. With source mitigation in place, the majority of the residents were still predicted to be awoken at least once per night (median 88.0%), although substantial reductions in the median probabilities of awakening three and five times per night from 50.9 to 29.4% and 9.2 to 2.7%, respectively, were predicted. This resulted in a cost-effective estimate of 7.6-8.8 less people being awoken at least three times per night per A$1 million spent on noise barriers. CONCLUSION: The study demonstrates that an easily understood metric can be readily used to assist making decisions related to noise mitigation for large-scale transport projects.
[Mh] Termos MeSH primário: Recuperação e Remediação Ambiental
Ruído dos Transportes/efeitos adversos
Ruído dos Transportes/prevenção & controle
Ferrovias
Transtornos do Sono-Vigília/etiologia
Transtornos do Sono-Vigília/prevenção & controle
[Mh] Termos MeSH secundário: Materiais de Construção
Seres Humanos
New South Wales
Vibração
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.4103/nah.NAH_101_16


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[PMID]:28747136
[Au] Autor:Kahya M; Vidoni E; Burns JM; Thompson AN; Meyer K; Siengsukon CF
[Ad] Endereço:1 Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, KS, USA.
[Ti] Título:The Relationship Between Apolipoprotein ε4 Carrier Status and Sleep Characteristics in Cognitively Normal Older Adults.
[So] Source:J Geriatr Psychiatry Neurol;30(5):273-279, 2017 Sep.
[Is] ISSN:0891-9887
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The apolipoprotein (APOE) ε4 allele, a well-described genetic risk factor for late-onset Alzheimer disease (AD), is associated with sleep disturbances even in cognitively normal older adults, although it is not clear whether this association is independent of sleep apnea. We sought to extend previous studies by examining whether cognitively normal older adults without self-reported sleep apnea who carry the APOE ε4 allele have altered sleep characteristics compared to noncarriers. Data from N = 36 (APOE ε4 carriers [n = 9], noncarriers [n = 27]) cognitively normal older adults (Clinical Dementia Rating [CDR] scale = 0) without self-reported sleep apnea were used for these analyses. Participants wore an actigraph for 7 days to determine sleep characteristics. The Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) were used to assess sleep quality and daytime sleepiness, respectively. The APOE ε4 carriers had a higher number of awakenings compared to the noncarriers ( P = .02). There was no significant difference in the PSQI global score and the ESS; however, the PSQI subcomponent of daily disturbances was significantly higher in APOE ε4 carriers ( P = .03), indicating increased daytime dysfunction is related to disrupted sleep. This study provides evidence that individuals who are cognitively normal and genetically at risk of AD may have disrupted sleep. These findings are consistent with prior studies and suggest that sleep disruption may be present in the presymptomatic stages of AD.
[Mh] Termos MeSH primário: Doença de Alzheimer/genética
Apolipoproteínas E/genética
Cognição/fisiologia
Transtornos do Sono-Vigília/genética
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Masculino
Transtornos do Sono-Vigília/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ApoE protein, human); 0 (Apolipoproteins E)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1177/0891988717720301


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[PMID]:29357377
[Au] Autor:Bourcier E; Korb-Savoldelli V; Hejblum G; Fernandez C; Hindlet P
[Ad] Endereço:Sorbonne Université, INSERM, Institut Pierre Louis d'épidémiologie et de Santé Publique, IPLESP UMR-S1136, Paris, France.
[Ti] Título:A systematic review of regulatory and educational interventions to reduce the burden associated with the prescriptions of sedative-hypnotics in adults treated for sleep disorders.
[So] Source:PLoS One;13(1):e0191211, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The burden of Sedative-Hypnotics (SHs) has been known since the 1980s. Yet, their consumption remains high. A systematic review of the literature should help to assess efficient interventions to improve the appropriate use of SHs in sleep disorders. OBJECTIVES: To identify and assess regulatory and educational interventions designed to improve the appropriate use of SHs for insomnia treatment. METHODS: We conducted a systematic review of the literature according to PRISMA guidelines. A systematic search covering the period 1980-2015 was carried out in Medline, Web of Science, Embase and PsycInfo. We included studies reporting the implementation of regulatory or educational strategies directed towards patients and/or healthcare professionals to improve the appropriate use of SHs to treat insomnia in the community, hospitals and nursing homes. RESULTS: Thirty-one studies were included: 23 assessed educational interventions (recommendations by mail/email, computer alerts, meetings, mass media campaigns, prescription profile), 8 assessed regulatory interventions (prescription rule restriction, end of reimbursement). The most recent was implemented in 2009. Restrictive prescription rules were effective to reduce the consumption of targeted SHs but led to a switch to other non-recommended SHs. Among educational interventions, only 3 studies out of 7 reported positive results of mono-faceted interventions; whereas, 13 out of the 16 multi-faceted interventions were reported as efficient: particularly, the active involvement of healthcare professionals and patients and the spread of information through mass media were successful. The risk of bias was high for 24 studies (mainly due to the design), moderate for 3 studies and weak for 4 studies. CONCLUSION: Educational multifaceted studies are presented as the most efficient. But further better designed studies are needed to make evidence-based results more generalizable.
[Mh] Termos MeSH primário: Hipnóticos e Sedativos/uso terapêutico
Transtornos do Sono-Vigília/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Prescrições de Medicamentos
Seres Humanos
Hipnóticos e Sedativos/administração & dosagem
Hipnóticos e Sedativos/efeitos adversos
Legislação de Medicamentos
Educação de Pacientes como Assunto
Distúrbios do Início e da Manutenção do Sono/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Hypnotics and Sedatives)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180123
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191211



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