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[PMID]:28276943
[Au] Autor:Mahdavinia M; Schleimer RP; Keshavarzian A
[Ad] Endereço:a Allergy and Immunology Section, Department of Immunology and Microbiology , Rush University Medical Center , Chicago , IL , USA.
[Ti] Título:Sleep disruption in chronic rhinosinusitis.
[So] Source:Expert Rev Anti Infect Ther;15(5):457-465, 2017 May.
[Is] ISSN:1744-8336
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Chronic rhinosinusitis (CRS) is a common disease of the upper airways and paranasal sinuses with a marked decline in quality of life (QOL). CRS patients suffer from sleep disruption at a significantly higher proportion (60 to 75%) than in the general population (8-18 %). Sleep disruption in CRS causes decreased QOL and is linked to poor functional outcomes such as impaired cognitive function and depression. Areas covered: A systematic PubMed/Medline search was done to assess the results of studies that have investigated sleep and sleep disturbances in CRS. Expert commentary: These studies reported sleep disruption in most CRS patients. The main risk factors for sleep disruption in CRS include allergic rhinitis, smoking, and high SNOT-22 total scores. The literature is inconsistent with regard to the prevalence of sleep-related disordered breathing (e.g. obstructive sleep apnea) in CRS patients. Although nasal obstruction is linked to sleep disruption, the extent of sleep disruption in CRS seems to expand beyond that expected from physical blockage of the upper airways alone. Despite the high prevalence of sleep disruption in CRS, and its detrimental effects on QOL, the literature contains a paucity of studies that have investigated the mechanisms underlying this major problem in CRS.
[Mh] Termos MeSH primário: Obstrução Nasal/fisiopatologia
Qualidade de Vida/psicologia
Rinite/fisiopatologia
Sinusite/fisiopatologia
Transtornos Intrínsecos do Sono/fisiopatologia
[Mh] Termos MeSH secundário: Doença Crônica
Disfunção Cognitiva/diagnóstico
Disfunção Cognitiva/etiologia
Disfunção Cognitiva/fisiopatologia
Disfunção Cognitiva/psicologia
Depressão/diagnóstico
Depressão/etiologia
Depressão/fisiopatologia
Depressão/psicologia
Seres Humanos
Obstrução Nasal/complicações
Obstrução Nasal/diagnóstico
Obstrução Nasal/psicologia
Rinite/complicações
Rinite/diagnóstico
Rinite/psicologia
Sinusite/complicações
Sinusite/diagnóstico
Sinusite/psicologia
Transtornos Intrínsecos do Sono/complicações
Transtornos Intrínsecos do Sono/diagnóstico
Transtornos Intrínsecos do Sono/psicologia
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1080/14787210.2017.1294063


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[PMID]:28063757
[Au] Autor:Azulay JP; Witjas T; Eusebio A
[Ad] Endereço:AP-HM, hôpital de la Timone, centre expert pour la maladie de Parkinson, service de neurologie et pathologie du mouvement, 13385 Marseille, France. Electronic address: jean-philippe.azulay@ap-hm.fr.
[Ti] Título:[No motor signs in Parkinson's disease].
[Ti] Título:Les signes non moteurs de la maladie de Parkinson..
[So] Source:Presse Med;46(2 Pt 1):195-201, 2017 Mar.
[Is] ISSN:2213-0276
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:In Parkinson's disease, motor signs have long been the main targets of the management of the disease. In recent years, non-motor disorders have elicited increasing interest. These disorders are under diagnosed and managed more difficultly than motor signs and are sometimes perceived as more disturbing by the patients. These signs are polymorphous, sometimes occurring before the motor symptoms but increase with the disease duration and complicating always the late stages. They may fluctuate as the motor signs, while being under the control of dopaminergic pathways, or be linked to the degeneration of other neuronal circuits. These clinical manifestations, whether or not fluctuating are classified into three major categories: psycho-cognitive including sleep disorders, autonomic and sensory.
[Mh] Termos MeSH primário: Transtornos Cognitivos/etiologia
Doença de Parkinson/complicações
Disautonomias Primárias/etiologia
Transtornos das Sensações/etiologia
Transtornos Intrínsecos do Sono/etiologia
[Mh] Termos MeSH secundário: Transtornos Cognitivos/fisiopatologia
Transtorno Depressivo/etiologia
Progressão da Doença
Neurônios Dopaminérgicos/fisiologia
Feminino
Gastroenteropatias/etiologia
Gastroenteropatias/fisiopatologia
Seres Humanos
Masculino
Neuralgia/etiologia
Neuralgia/fisiopatologia
Doença de Parkinson/fisiopatologia
Disautonomias Primárias/fisiopatologia
Transtorno do Comportamento do Sono REM/etiologia
Transtorno do Comportamento do Sono REM/fisiopatologia
Transtornos das Sensações/fisiopatologia
Fatores Sexuais
Transtornos Intrínsecos do Sono/fisiopatologia
Avaliação de Sintomas
Transtornos Urinários/etiologia
Transtornos Urinários/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170406
[Lr] Data última revisão:
170406
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170109
[St] Status:MEDLINE


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[PMID]:27609325
[Au] Autor:Yong LC; Li J; Calvert GM
[Ad] Endereço:Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA.
[Ti] Título:Sleep-related problems in the US working population: prevalence and association with shiftwork status.
[So] Source:Occup Environ Med;74(2):93-104, 2017 Feb.
[Is] ISSN:1470-7926
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To estimate the prevalence of a comprehensive set of self-reported sleep problems by job characteristics, including shiftwork status, among a representative sample of US workers. METHODS: Data for 6338 workers aged ≥18 years were obtained from the National Health and Nutrition Examination Survey. Short sleep duration was defined as <7 hours per weekday/workday. Sleep quality was categorised as good, moderate and poor based on the frequency of 6 sleep-related symptoms. A sleep-related activities of daily living (ADL) score ≥2 was defined as impaired. Insomnia was defined as having poor sleep quality and impaired ADL. Shiftwork status was categorised as daytime, night, evening, rotating or another schedule. Prevalence rates were calculated and multivariate logistic regression analyses were used. RESULTS: The prevalence of short sleep duration (37.6% overall) was highest among night shift workers (61.8%; p<0.001). The prevalence of poor sleep quality was 19.2% among all workers, with the highest prevalence among night shift workers (30.7%, p=0.004). The prevalence of impaired ADL score (24.8% overall) and insomnia (8.8% overall) was also highest for night shift workers (36.2%, p=0.001 and 18.5%, p=0.013, respectively). In multivariate analysis, night shift workers had the highest likelihood of these sleep problems. CONCLUSIONS: Self-reported short sleep duration, poor sleep quality, impaired ADL score and insomnia are common among US workers especially among night shift workers. Although these findings should be confirmed with objective sleep measures, they support the need for intervention programmes to improve sleep quantity and quality among night shift workers.
[Mh] Termos MeSH primário: Doenças Profissionais/epidemiologia
Doenças Profissionais/etiologia
Transtornos do Sono do Ritmo Circadiano/epidemiologia
Transtornos Intrínsecos do Sono/epidemiologia
Tolerância ao Trabalho Programado
[Mh] Termos MeSH secundário: Atividades Cotidianas
Adolescente
Adulto
Distribuição por Idade
Idoso
Feminino
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Inquéritos Nutricionais
Prevalência
Fatores de Risco
Distribuição por Sexo
Transtornos do Sono do Ritmo Circadiano/diagnóstico
Estados Unidos/epidemiologia
Tolerância ao Trabalho Programado/psicologia
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160910
[St] Status:MEDLINE
[do] DOI:10.1136/oemed-2016-103638


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[PMID]:27907272
[Au] Autor:Hafeez MU; Molero H; Hurwitz TD; Khawaja IS
[Ad] Endereço:ubaid_hafeez@yahoo.com.
[Ti] Título:A Case Report of Wake State Misperception, or Reverse Sleep State Misperception, in a Patient With Dementia and REM Sleep Without Atonia.
[So] Source:Prim Care Companion CNS Disord;18(6), 2016 Nov 03.
[Is] ISSN:2155-7780
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Demência/complicações
Transtorno do Comportamento do Sono REM/complicações
Transtornos Intrínsecos do Sono/complicações
[Mh] Termos MeSH secundário: Idoso
Demência/tratamento farmacológico
Demência/fisiopatologia
Seres Humanos
Masculino
Transtorno do Comportamento do Sono REM/tratamento farmacológico
Transtorno do Comportamento do Sono REM/fisiopatologia
Transtornos Intrínsecos do Sono/tratamento farmacológico
Transtornos Intrínsecos do Sono/fisiopatologia
[Pt] Tipo de publicação:CASE REPORTS; LETTER; REVIEW
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161202
[St] Status:MEDLINE
[do] DOI:10.4088/PCC.15l01928


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[PMID]:27403929
[Au] Autor:Kische H; Ewert R; Fietze I; Gross S; Wallaschofski H; Völzke H; Dörr M; Nauck M; Obst A; Stubbe B; Penzel T; Haring R
[Ad] Endereço:Institute of Clinical Chemistry and Laboratory Medicine (H.K., H.W., M.N., R.H.), Departments of Internal Medicine B (R.E., A.O., B.S.) and Cardiology (S.G., M.D.), and Institute for Community Medicine (H.V.), University Medicine Greifswald, D-17475 Greifswald, Germany; Interdisciplinary Sleep Cente
[Ti] Título:Sex Hormones and Sleep in Men and Women From the General Population: A Cross-Sectional Observational Study.
[So] Source:J Clin Endocrinol Metab;101(11):3968-3977, 2016 Nov.
[Is] ISSN:1945-7197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CONTEXT AND OBJECTIVES: Associations between sex hormones and sleep habits originate mainly from small and selected patient-based samples. We examined data from a population-based sample with various sleep characteristics and the major part of sex hormones measured by mass spectrometry. DESIGN, SETTING, AND PARTICIPANTS: We used data from 204 men and 213 women of the cross-sectional Study of Health in Pomerania-TREND. MAIN OUTCOME AND MEASURES: Associations of total T (TT) and free T, androstenedione (ASD), estrone, estradiol (E2), dehydroepiandrosterone-sulphate, SHBG, and E2 to TT ratio with sleep measures (including total sleep time, sleep efficiency, wake after sleep onset, apnea-hypopnea index [AHI], Insomnia Severity Index, Epworth Sleepiness Scale, and Pittsburgh Sleep Quality Index) were assessed by sex-specific multivariable regression models. RESULTS: In men, age-adjusted associations of TT (odds ratio 0.62; 95% confidence interval (CI) 0.46-0.83), free T, and SHBG with AHI were rendered nonsignificant after multivariable adjustment. In multivariable analyses, ASD was associated with Epworth Sleepiness Scale (ß-coefficient per SD increase in ASD: -0.71; 95% CI: -1.18 to -0.25). In women, multivariable analyses showed positive associations of dehydroepiandrosterone-sulphate with wake after sleep onset (ß-coefficient: .16; 95% CI 0.03-0.28) and of E2 and E2 to TT ratio with Epworth Sleepiness Scale. Additionally, free T and SHBG were associated with AHI in multivariable models among premenopausal women. CONCLUSIONS: The present cross-sectional, population-based study observed sex-specific associations of androgens, E2, and SHBG with sleep apnea and daytime sleepiness. However, multivariable-adjusted analyses confirmed the impact of body composition and health-related lifestyle on the association between sex hormones and sleep.
[Mh] Termos MeSH primário: Androstenodiona/sangue
Sulfato de Desidroepiandrosterona/sangue
Estradiol/sangue
Estrona/sangue
Globulina de Ligação a Hormônio Sexual/análise
Transtornos Intrínsecos do Sono/sangue
Testosterona/sangue
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Algoritmos
Estudos de Coortes
Estudos Transversais
Feminino
Alemanha/epidemiologia
Seres Humanos
Masculino
Polissonografia
Prevalência
Índice de Gravidade de Doença
Fatores Sexuais
Síndromes da Apneia do Sono/sangue
Síndromes da Apneia do Sono/epidemiologia
Síndromes da Apneia do Sono/fisiopatologia
Transtornos Intrínsecos do Sono/epidemiologia
Transtornos Intrínsecos do Sono/fisiopatologia
Distúrbios do Início e da Manutenção do Sono/sangue
Distúrbios do Início e da Manutenção do Sono/epidemiologia
Distúrbios do Início e da Manutenção do Sono/fisiopatologia
Transtornos do Sono-Vigília/sangue
Transtornos do Sono-Vigília/epidemiologia
Transtornos do Sono-Vigília/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Sex Hormone-Binding Globulin); 2DI9HA706A (Estrone); 3XMK78S47O (Testosterone); 409J2J96VR (Androstenedione); 4TI98Z838E (Estradiol); 57B09Q7FJR (Dehydroepiandrosterone Sulfate)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170602
[Lr] Data última revisão:
170602
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160713
[St] Status:MEDLINE


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[PMID]:26825913
[Au] Autor:Chen CH; Yang TY; Lin CL; Chen CS; Lin WM; Kuo CN; Lin MC; Kao CH
[Ad] Endereço:From the Department of Medical Laboratory Science and Biotechnology (CHC); Molecular and Genomic Epidemiology Center, China Medical University Hospital, China Medical University, Taichung (T-YY); Division of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, Changhua (T-YY); Management Office for Health Data, China Medical University Hospital (C-LL); College of Medicine (C-LL); Division of Chinese Trauma, China Medical University Hospital, China Medical University, Taichung (C-SC); Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi (W-ML); Chang Gung University, Taoyuan (W-ML); Kau-Tang Traditional Medical Hospital, Taichung (C-NK); Department of Nuclear Medicine, I-Shou University, Kaohsiung (M-GL); Department of Nuclear Medicine and PET Center, China Medical University Hospital (C-HK); and Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan (C-HK).
[Ti] Título:Dry Eye Syndrome Risks in Patients With Fibromyalgia: A National Retrospective Cohort Study.
[So] Source:Medicine (Baltimore);95(4):e2607, 2016 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The coexistence of fibromyalgia (FM) and dry eye syndrome (DES) has been previously reported. However, there are few studies on how patients with FM may develop concomitant DES. Patients with chronic widespread pain, like FM, chronic fatigue syndrome, and irritable bowel syndrome (IBS), was concerned for the rheumatic or psychosomatic disorders which might adequately reflect the long-term risk of DES. We retrieved data on FM patients from the National Health Insurance Research Database of Taiwan covering the years 2000 to 2011. Our FM population consisted of 25,777 patients versus 103,108 patients in the non-FM group: the overall incidence of DES in these populations was 7.37/10,000 and 4.81/10,000, respectively. Male FM patients had a higher incidence of DES, with a 1.39-fold DES risk for males and a 1.45-fold for females after adjustment for confounding factor. Notably, FM patients aged ≤49 years had an elevated 80% risk of DES compared with the non-FM group. Without comorbidities, FM patients had an approximately 1.40-fold risk of DES than those without FM. The additive effects of FM and IBS or FM and sleep disturbance were pointed out that the risk for DES would be elevated when the FM patients with IBS or sleep disturbance. FM patients have a higher incidence of DES than that of non-FM patients. They carry long-term DES risks from a relatively young age, particularly those with psychiatric problems. Risk stratification for a timely psychiatric medication intervention and risk modifications are not intended.
[Mh] Termos MeSH primário: Síndromes do Olho Seco/epidemiologia
Fibromialgia/epidemiologia
Síndrome do Intestino Irritável/epidemiologia
Transtornos Intrínsecos do Sono/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Analgésicos Opioides/uso terapêutico
Ansiolíticos/uso terapêutico
Antidepressivos/uso terapêutico
Ansiedade/tratamento farmacológico
Ansiedade/epidemiologia
Estudos de Casos e Controles
Comorbidade
Depressão/tratamento farmacológico
Depressão/epidemiologia
Feminino
Fibromialgia/tratamento farmacológico
Seres Humanos
Incidência
Masculino
Meia-Idade
Prevalência
Estudos Retrospectivos
Fatores de Risco
Fatores Sexuais
Taiwan/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Analgesics, Opioid); 0 (Anti-Anxiety Agents); 0 (Antidepressive Agents)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160131
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000002607


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[PMID]:26727258
[Au] Autor:Weissová K; Bartos A; Sládek M; Nováková M; Sumová A
[Ad] Endereço:Department of Neurohumoral Regulations, Institute of Physiology, the Czech Academy of Sciences, Prague, Czech Republic.
[Ti] Título:Moderate Changes in the Circadian System of Alzheimer's Disease Patients Detected in Their Home Environment.
[So] Source:PLoS One;11(1):e0146200, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Alzheimer's disease (AD) is a neurodegenerative disease often accompanied with disruption of sleep-wake cycle. The sleep-wake cycle is controlled by mechanisms involving internal timekeeping (circadian) regulation. The aim of our present pilot study was to assess the circadian system in patients with mild form of AD in their home environment. In the study, 13 elderly AD patients and 13 age-matched healthy control subjects (the patient's spouses) were enrolled. Sleep was recorded for 21 days by sleep diaries in all participants and checked by actigraphy in 4 of the AD patient/control couples. The samples of saliva and buccal mucosa were collected every 4 hours during the same 24 h-interval to detect melatonin and clock gene (PER1 and BMAL1) mRNA levels, respectively. The AD patients exhibited significantly longer inactivity interval during the 24 h and significantly higher number of daytime naps than controls. Daily profiles of melatonin levels exhibited circadian rhythms in both groups. Compared with controls, decline in amplitude of the melatonin rhythm in AD patients was not significant, however, in AD patients more melatonin profiles were dampened or had atypical waveforms. The clock genes PER1 and BMAL1 were expressed rhythmically with high amplitudes in both groups and no significant differences in phases between both groups were detected. Our results suggest moderate differences in functional state of the circadian system in patients with mild form of AD compared with healthy controls which are present in conditions of their home dwelling.
[Mh] Termos MeSH primário: Doença de Alzheimer/fisiopatologia
Ritmo Circadiano/fisiologia
[Mh] Termos MeSH secundário: Fatores de Transcrição ARNTL/biossíntese
Fatores de Transcrição ARNTL/genética
Actigrafia
Idoso
Idoso de 80 Anos ou mais
Doença de Alzheimer/complicações
Estudos de Casos e Controles
Meio Ambiente
Feminino
Regulação da Expressão Gênica
Habitação
Seres Humanos
Masculino
Registros Médicos
Melatonina/análise
Mucosa Bucal/química
Proteínas Circadianas Period/biossíntese
Proteínas Circadianas Period/genética
RNA Mensageiro/análise
RNA Mensageiro/biossíntese
Saliva/química
Transtornos Intrínsecos do Sono/complicações
Transtornos Intrínsecos do Sono/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (ARNTL Transcription Factors); 0 (ARNTL protein, human); 0 (PER1 protein, human); 0 (Period Circadian Proteins); 0 (RNA, Messenger); JL5DK93RCL (Melatonin)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160105
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0146200


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[PMID]:26423332
[Au] Autor:Aazami S; Mozafari M; Shamsuddin K; Akmal S
[Ad] Endereço:Department of Nursing, Faculty of Nursing and Midwifery, Ilam University of Medical Science, Iran.
[Ti] Título:Work-family conflict and sleep disturbance: the Malaysian working women study.
[So] Source:Ind Health;54(1):50-7, 2016.
[Is] ISSN:1880-8026
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:This study aimed at assessing effect of the four dimensions of work-family conflicts (strain and time-based work interference into family and family interference into work) on sleep disturbance in Malaysian working women. This cross-sectional study was conducted among 325 Malaysian married working women. Multiple-stage simple random sampling method was used to recruit women from public service departments of Malaysia. Self-administrated questionnaires were used to measure the study variables and data were analyzed using SPSS version 21. We found that high level of the four dimensions of work-family conflicts significantly increase sleep disturbance. Our analyses also revealed an age-dependent effect of the work-family conflict on sleep disturbance. Women in their 20 to 30 yr old suffer from sleep disturbance due to high level of time-based and strain-based work-interference into family. However, the quality of sleep among women aged 30-39 were affected by strain-based family-interference into work. Finally, women older than 40 yr had significantly disturbed sleep due to strain-based work-interference into family as well as time-based family interference into work. Our findings showed that sleep quality of working women might be disturbed by experiencing high level of work-family conflict. However, the effects of inter-role conflicts on sleep varied among different age groups.
[Mh] Termos MeSH primário: Conflito (Psicologia)
Transtornos Intrínsecos do Sono/etiologia
Estresse Psicológico/psicologia
Equilíbrio Trabalho-Vida
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Estudos Transversais
Família
Feminino
Seres Humanos
Malásia
Meia-Idade
Inquéritos e Questionários
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151002
[St] Status:MEDLINE
[do] DOI:10.2486/indhealth.2015-0086


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[PMID]:26134878
[Au] Autor:Jafari N; Pahwa R; Nazzaro JM; Arnold PM; Lyons KE
[Ad] Endereço:a 1 University of Kansas School of Medicine , USA.
[Ti] Título:MDS-UPDRS to assess non-motor symptoms after STN DBS for Parkinson's disease.
[So] Source:Int J Neurosci;126(1):25-9, 2016.
[Is] ISSN:1563-5279
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine if the non-motor sections of the Movement Disorder Society's (MDS) version of the Unified Parkinson's Disease Rating Scale (UPDRS) could supplement the original UPDRS as a patient completed assessment of changes in non-motor symptoms in Parkinson's disease (PD) patients after bilateral subthalamic nucleus (STN) deep brain stimulation (DBS). METHODS: Thirty PD patients who underwent bilateral STN DBS were assessed using the total UPDRS and the non-motor sections of the MDS-UPDRS prior to surgery and one year following surgery. This study focuses on non-motor symptoms as assessed by Part I of the UPDRS and Part 1A and 1B of the MDS-UPDRS. RESULTS: One year following surgery, no individual non-motor symptoms or the total mentation score of the UPDRS were significantly changed. In comparison, the MDS-UPDRS showed significant improvements in sleep and urinary problems and a trend towards improvement in anxiety, constipation, daytime sleepiness, fatigue and pain. CONCLUSIONS: This study provides evidence that the MDS-UPDRS non-motor sections, when completed by the patients, can supplement the original version of the UPDRS as an effective method of measuring changes in non-motor symptoms after DBS. It also reinforces the benefits of bilateral STN DBS on non-motor symptoms of PD.
[Mh] Termos MeSH primário: Estimulação Encefálica Profunda
Doença de Parkinson/terapia
Índice de Gravidade de Doença
Núcleo Subtalâmico
Avaliação de Sintomas/métodos
[Mh] Termos MeSH secundário: Idoso
Ansiedade/etiologia
Ansiedade/terapia
Transtornos Cognitivos/etiologia
Transtornos Cognitivos/terapia
Constipação Intestinal/etiologia
Constipação Intestinal/terapia
Fadiga/etiologia
Fadiga/terapia
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Dor/etiologia
Doença de Parkinson/complicações
Doença de Parkinson/fisiopatologia
Transtornos Intrínsecos do Sono/etiologia
Transtornos Intrínsecos do Sono/terapia
Núcleo Subtalâmico/fisiopatologia
Resultado do Tratamento
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151204
[Lr] Data última revisão:
151204
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150703
[St] Status:MEDLINE
[do] DOI:10.3109/00207454.2015.1065257


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[PMID]:26444000
[Au] Autor:Ammanuel S; Chan WC; Adler DA; Lakshamanan BM; Gupta SS; Ewen JB; Johnston MV; Marcus CL; Naidu S; Kadam SD
[Ad] Endereço:Neuroscience Laboratory, Hugo Moser Research Institute at Kennedy Krieger, Baltimore, Maryland, United States of America; Department of Biomedical Engineering, Whiting School of Engineering,Johns Hopkins University, Baltimore, Maryland, United States of America.
[Ti] Título:Heightened Delta Power during Slow-Wave-Sleep in Patients with Rett Syndrome Associated with Poor Sleep Efficiency.
[So] Source:PLoS One;10(10):e0138113, 2015.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sleep problems are commonly reported in Rett syndrome (RTT); however the electroencephalographic (EEG) biomarkers underlying sleep dysfunction are poorly understood. The aim of this study was to analyze the temporal evolution of quantitative EEG (qEEG) biomarkers in overnight EEGs recorded from girls (2-9 yrs. old) diagnosed with RTT using a non-traditional automated protocol. In this study, EEG spectral analysis identified high delta power cycles representing slow wave sleep (SWS) in 8-9h overnight sleep EEGs from the frontal, central and occipital leads (AP axis), comparing age-matched girls with and without RTT. Automated algorithms quantitated the area under the curve (AUC) within identified SWS cycles for each spectral frequency wave form. Both age-matched RTT and control EEGs showed similar increasing trends for recorded delta wave power in the EEG leads along the antero-posterior (AP). RTT EEGs had significantly fewer numbers of SWS sleep cycles; therefore, the overall time spent in SWS was also significantly lower in RTT. In contrast, the AUC for delta power within each SWS cycle was significantly heightened in RTT and remained heightened over consecutive cycles unlike control EEGs that showed an overnight decrement of delta power in consecutive cycles. Gamma wave power associated with these SWS cycles was similar to controls. However, the negative correlation of gamma power with age (r = -.59; p<0.01) detected in controls (2-5 yrs. vs. 6-9 yrs.) was lost in RTT. Poor % SWS (i.e., time spent in SWS overnight) in RTT was also driven by the younger age-group. Incidence of seizures in RTT was associated with significantly lower number of SWS cycles. Therefore, qEEG biomarkers of SWS in RTT evolved temporally and correlated significantly with clinical severity.
[Mh] Termos MeSH primário: Ondas Encefálicas/fisiologia
Síndrome de Rett/genética
Transtornos Intrínsecos do Sono/fisiopatologia
Fases do Sono/fisiologia
[Mh] Termos MeSH secundário: Biomarcadores/análise
Criança
Pré-Escolar
Eletroencefalografia
Feminino
Seres Humanos
Proteína 2 de Ligação a Metil-CpG/genética
Polissonografia
Estudos Retrospectivos
Síndrome de Rett/patologia
Transtornos Intrínsecos do Sono/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Biomarkers); 0 (MECP2 protein, human); 0 (Methyl-CpG-Binding Protein 2)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151008
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0138113



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