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[PMID]:29250981
[Au] Autor:Evangelista E; Lopez R; Dauvilliers Y
[Ad] Endereço:a Centre National de Référence Narcolepsie Hypersomnies, Unité des Troubles du Sommeil, Service de Neurologie , Hôpital Gui-de-Chauliac Montpellier , Montpellier , France.
[Ti] Título:Update on treatment for idiopathic hypersomnia.
[So] Source:Expert Opin Investig Drugs;27(2):187-192, 2018 Feb.
[Is] ISSN:1744-7658
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Idiopathic hypersomnia (IH) is a poorly characterized orphan central disorder of hypersomnolence responsible for excessive daytime sleepiness (EDS), prolonged nighttime sleep and sleep inertia that often require long-term symptomatic stimulant medication. To date, no drug has currently the authorization for the treatment of IH patients worldwide. Areas covered: The authors reviewed data on pharmacological treatment of IH obtained from published literature (Medline/PubMed/Web of Science) and Clinicaltrial.gov database from 1997 to 2017. Most of data on treatment of IH derived from observational studies and case series with only three well-designed clinical trials available. Expert opinion: In two recent randomized, double-blind, placebo-controlled trials, modafinil improves EDS in IH. Most of other wakefulness-promoting agents labeled for narcolepsy have similar efficacy in cases series of IH patients. Pitolisant and sodium oxybate show promising results in two retrospective studies. The efficacy of γ-aminobutyric acid-A receptor antagonists on objective EDS needs to be clarified. All these medications are used off-label for the management of EDS in IH. Specific clinical instruments and objective tests are required in IH to better evaluate the severity of EDS and responsiveness to medications, but also prolonged sleep and sleep inertia, to optimize the whole management of IH patients.
[Mh] Termos MeSH primário: Estimulantes do Sistema Nervoso Central/uso terapêutico
Hipersonolência Idiopática/tratamento farmacológico
Promotores da Vigília/uso terapêutico
[Mh] Termos MeSH secundário: Aprovação de Drogas
Antagonistas de Receptores de GABA-A/uso terapêutico
Seres Humanos
Hipersonolência Idiopática/fisiopatologia
Uso Off-Label
Ensaios Clínicos Controlados Aleatórios como Assunto
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Central Nervous System Stimulants); 0 (GABA-A Receptor Antagonists); 0 (Wakefulness-Promoting Agents)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1080/13543784.2018.1417385


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[PMID]:28364448
[Au] Autor:Jørgen Jennum P; Østergaard Pedersen L; Czarna Bahl JM; Modvig S; Fog K; Holm A; Rahbek Kornum B; Gammeltoft S
[Ad] Endereço:Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Rigshospitalet, Denmark.
[Ti] Título:Cerebrospinal Fluid Biomarkers of Neurodegeneration Are Decreased or Normal in Narcolepsy.
[So] Source:Sleep;40(1), 2017 Jan 01.
[Is] ISSN:1550-9109
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Objectives: To investigate whether cerebrospinal fluid (CSF) biomarkers of neurodegeneration are altered in narcolepsy in order to evaluate whether the hypocretin deficiency and abnormal sleep-wake pattern in narcolepsy leads to neurodegeneration. Methods: Twenty-one patients with central hypersomnia (10 type 1 narcolepsy, 5 type 2 narcolepsy, and 6 idiopathic hypersomnia cases), aged 33 years on average and with a disease duration of 2-29 years, and 12 healthy controls underwent CSF analyses of the levels of ß-amyloid, total tau protein (T-tau), phosphorylated tau protein (P-tau181), α-synuclein, neurofilament light chain (NF-L), and chitinase 3-like protein-1 (CHI3L1). Results: Levels of ß-amyloid were lower in patients with type 1 narcolepsy (375.4 ± 143.5 pg/mL) and type 2 narcolepsy (455.9 ± 65.0 pg/mL) compared to controls (697.9 ± 167.3 pg/mL, p < .05). Furthermore, in patients with type 1 narcolepsy, levels of T-tau (79.0 ± 27.5 pg/mL) and P-tau181 (19.1 ± 4.3 pg/mL) were lower than in controls (162.2 ± 49.9 pg/mL and 33.8 ± 9.2 pg/mL, p < .05). Levels of α-synuclein, NF-L, and CHI3L1 in CSF from narcolepsy patients were similar to those of healthy individuals. Conclusion: Six CSF biomarkers of neurodegeneration were decreased or normal in narcolepsy indicating that taupathy, synucleinopathy, and immunopathy are not prevalent in narcolepsy patients with a disease duration of 2-29 years. Lower CSF levels of ß-amyloid, T-tau protein, and P-tau181 in narcolepsy may indicate that hypocretin deficiency and an abnormal sleep-wake pattern alter the turnover of these proteins in the central nervous system.
[Mh] Termos MeSH primário: Biomarcadores/líquido cefalorraquidiano
Narcolepsia/líquido cefalorraquidiano
Doenças Neurodegenerativas/líquido cefalorraquidiano
[Mh] Termos MeSH secundário: Adulto
Peptídeos beta-Amiloides/líquido cefalorraquidiano
Estudos de Casos e Controles
Proteína 1 Semelhante à Quitinase-3/líquido cefalorraquidiano
Feminino
Seres Humanos
Hipersonolência Idiopática/líquido cefalorraquidiano
Masculino
Proteínas de Neurofilamentos/líquido cefalorraquidiano
Orexinas/líquido cefalorraquidiano
alfa-Sinucleína/líquido cefalorraquidiano
Proteínas tau/líquido cefalorraquidiano
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amyloid beta-Peptides); 0 (Biomarkers); 0 (CHI3L1 protein, human); 0 (Chitinase-3-Like Protein 1); 0 (Neurofilament Proteins); 0 (Orexins); 0 (alpha-Synuclein); 0 (neurofilament protein L); 0 (tau Proteins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170402
[St] Status:MEDLINE
[do] DOI:10.1093/sleep/zsw006


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[PMID]:28243864
[Au] Autor:Barateau L; Lopez R; Franchi JA; Dauvilliers Y
[Ad] Endereço:Sleep-Wake Disorders Center, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, 80 avenue Augustin Fliche, 34295, Montpellier Cedex 5, France.
[Ti] Título:Hypersomnolence, Hypersomnia, and Mood Disorders.
[So] Source:Curr Psychiatry Rep;19(2):13, 2017 Feb.
[Is] ISSN:1535-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Relationships between symptoms of hypersomnolence, psychiatric disorders, and hypersomnia disorders (i.e., narcolepsy and idiopathic hypersomnia) are complex and multidirectional. Hypersomnolence is a common complaint across mood disorders; however, patients suffering from mood disorders and hypersomnolence rarely have objective daytime sleepiness, as assessed by the current gold standard test, the Multiple Sleep Latency Test. An iatrogenic origin of symptoms of hypersomnolence, and sleep apnea syndrome must be considered in a population of psychiatric patients, often overweight and treated with sedative drugs. On the other hand, psychiatric comorbidities, especially depression symptoms, are often reported in patients with hypersomnia disorders, and an endogenous origin cannot be ruled out. A great challenge for sleep specialists and psychiatrists is to differentiate psychiatric hypersomnolence and a central hypersomnia disorder with comorbid psychiatric symptoms. The current diagnostic tools seem to be limited in that condition, and further research in that field is warranted.
[Mh] Termos MeSH primário: Distúrbios do Sono por Sonolência Excessiva/diagnóstico
Distúrbios do Sono por Sonolência Excessiva/psicologia
Hipersonolência Idiopática/diagnóstico
Hipersonolência Idiopática/psicologia
Transtornos Mentais/diagnóstico
Transtornos Mentais/psicologia
Narcolepsia/diagnóstico
Narcolepsia/psicologia
[Mh] Termos MeSH secundário: Comorbidade
Transtorno Depressivo Maior/diagnóstico
Transtorno Depressivo Maior/psicologia
Transtorno Depressivo Maior/terapia
Diagnóstico Diferencial
Distúrbios do Sono por Sonolência Excessiva/terapia
Seres Humanos
Hipersonolência Idiopática/terapia
Comunicação Interdisciplinar
Colaboração Intersetorial
Transtornos Mentais/terapia
Narcolepsia/terapia
Polissonografia
Psiquiatria
Síndromes da Apneia do Sono/diagnóstico
Síndromes da Apneia do Sono/psicologia
Síndromes da Apneia do Sono/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170301
[St] Status:MEDLINE
[do] DOI:10.1007/s11920-017-0763-0


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[PMID]:27838089
[Au] Autor:Leu-Semenescu S; Quera-Salva MA; Dauvilliers Y
[Ad] Endereço:Centre de référence nationale narcolepsie et hypersomnie idiopathique, 34295 Montpellier cedex 5, France; Service de pathologies du sommeil, GH Pitié-Salpêtrière/Charles-Foix, AP-HP, 75013 Paris, France; Inserm U 1127, CNRS UMR 7225, centre de recherche de l'institut du cerveau et de la moelle épinière, UPMC-Paris 6, 75013 Paris, France.
[Ti] Título:French consensus. Idiopathic hypersomnia: Investigations and follow-up.
[So] Source:Rev Neurol (Paris);173(1-2):32-37, 2017 Jan - Feb.
[Is] ISSN:0035-3787
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Idiopathic hypersomnia is a rare, central hypersomnia, recently identified and to date of unknown physiopathology. It is characterised by a more or less permanent, excessive daytime sleepiness, associated with long and unrefreshing naps. Night-time sleep is of good quality, excessive in quantity, associated with sleep inertia in the subtype previously described as "with long sleep time". Diagnosis of idiopathic hypersomnia is complex due to the absence of a quantifiable biomarker, the heterogeneous symptoms, which overlap with the clinical picture of type 2 narcolepsy, and its variable evolution over time. Detailed evaluation enables other frequent causes of somnolence, such as depression or sleep deprivation, to be eliminated. Polysomnography and multiple sleep latency tests (MSLT) are essential to rule out other sleep pathologies and to objectify excessive daytime sleepiness. Sometimes the MSLT do not show excessive sleepiness, hence a continued sleep recording of at least 24hours is necessary to show prolonged sleep (>11h/24h). In this article, we propose recommendations for the work-up to be carried out during diagnosis and follow-up for patients suffering from idiopathic hypersomnia.
[Mh] Termos MeSH primário: Hipersonolência Idiopática/diagnóstico
Hipersonolência Idiopática/terapia
[Mh] Termos MeSH secundário: Assistência ao Convalescente/métodos
Consenso
Diagnóstico Diferencial
Técnicas de Diagnóstico Neurológico
Seguimentos
França/epidemiologia
Seres Humanos
Hipersonolência Idiopática/epidemiologia
Polissonografia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161114
[St] Status:MEDLINE


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[PMID]:28083611
[Au] Autor:Vrana M; Siffnerova V; Pecherkova P; Ratajova E; Sonka K
[Ad] Endereço:HLA Department, Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20, Prague 2, Czech Republic. milena.vrana@uhkt.cz.
[Ti] Título:Distribution of HLA-DQB1 in Czech Patients with Central Hypersomnias.
[So] Source:Arch Immunol Ther Exp (Warsz);64(Suppl 1):89-98, 2016 Dec.
[Is] ISSN:1661-4917
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The aim of our study was to analyze the distribution of HLA-DQB1 in Czech patients with central hypersomnias and differences between diagnostic groups of narcolepsy type 1 (NT1), type 2 (NT2), idiopathic hypersomnia (IH) and no central hypersomnia subjects (no-CH). Statistical analysis of DQB1 genotyping was performed on the cohort of 716 patients (375 men, 341 women) with reported excessive daytime sleepiness. DQB1*06:02 allele was present in 94% of the NT1 patients. The decrease of DQB1*06:03 allele was also confirmed. No other DQB1*06 allele nor any other DQB1 allele group was differently distributed in the NT1. In the cohort of NT2 patients DQB1*06:02 allele was present in 43%. Allele group DQB*05 was detected with a significantly higher frequency in this diagnostic unit. Any differences in presence of DQB1*05 alleles in NT2 patients were not reported so far. The cohort of patients with IH did not show any difference in allele distribution of DQB1 alleles/allele groups comparing to healthy controls. DQB1*06:02 allele was significantly increased in the no hypersomnia group. No other DQB1 allele/allele group had any difference in distribution in patients comparing to healthy controls. The different distribution of DQB1*06:02 and other DQB1 alleles/allele groups was detected in analyzed diagnostic groups. These results indicate that DQB1 contributes to the genetic predisposition to NT1, NT2, IH and no-CH in different manners.
[Mh] Termos MeSH primário: Cadeias beta de HLA-DQ/genética
Hipersonolência Idiopática/genética
Narcolepsia/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Alelos
Estudos de Casos e Controles
Criança
Estudos de Coortes
República Tcheca
Distúrbios do Sono por Sonolência Excessiva/genética
Feminino
Frequência do Gene
Predisposição Genética para Doença
Genótipo
Seres Humanos
Masculino
Meia-Idade
Orexinas/metabolismo
Sono
Distúrbios do Início e da Manutenção do Sono/genética
Vigília
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (HLA-DQ beta-Chains); 0 (HLA-DQB1 antigen); 0 (Orexins)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170413
[Lr] Data última revisão:
170413
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170114
[St] Status:MEDLINE
[do] DOI:10.1007/s00005-016-0435-5


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[PMID]:27548094
[Au] Autor:Galbiati A; Abutalebi J; Iannaccone S; Borsa VM; Musteata S; Zucconi M; Giora E; Ferini-Strambi L
[Ti] Título:The effects of Transcranial Direct Current Stimulation (tDCS) on Idiopathic Hypersomnia: a pilot study.
[So] Source:Arch Ital Biol;154(1):1-5, 2016 Apr 01.
[Is] ISSN:0003-9829
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Idiopathic Hypersomnia (IH) is a rare sleep disorder characterised by excessive daytime sleepiness (EDS) that leads to invalidating daytime consequences. Till now the treatment of IH has mirrored that of sleepiness in narcolepsy, and it is mainly focused on symptoms' management. We employed an anodal transcranic Direct Current Stimulation (tDCS) treatment in order to induce a shift toward arousal in IH patients' cortex during the day. Every patients underwent a 4 weeks treatment (3 stimulations per week, for a total of 12 stimulations over a period of 28 days) with an assessment at the baseline and after treatment aimed to the evaluation of subjective daytime sleepiness, neurocognitive functions, and attentional domain tested by means of the Attentional Network Task (ANT). The dependent variables of the ANT are accuracy and reaction times, which represent the objective outcome of our study. A significant effect of tDCS' treatment in reducing EDS was found. Besides the amelioration in subjective EDS,  an objective improvement in RTs in all conditions of the ANT, in particular in the more difficult component, was observed. Our results indicate that tDCS may foster the management of EDS in IH, improving also the attentional domain.
[Mh] Termos MeSH primário: Hipersonolência Idiopática
[Mh] Termos MeSH secundário: Distúrbios do Sono por Sonolência Excessiva
Seres Humanos
Narcolepsia
Projetos Piloto
Estimulação Transcraniana por Corrente Contínua
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160823
[St] Status:MEDLINE
[do] DOI:10.12871/00039829201611


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[PMID]:27542882
[Au] Autor:Berkowski JA; Shelgikar AV
[Ad] Endereço:Michael S. Aldrich Sleep Disorders Laboratory, Department of Neurology, University of Michigan, 1500 East Medical Center Drive, SPC 5845, C728 Med Inn Building, Ann Arbor, MI 48109-5845, USA. Electronic address: andyberk@med.umich.edu.
[Ti] Título:Disorders of Excessive Daytime Sleepiness Including Narcolepsy and Idiopathic Hypersomnia.
[So] Source:Sleep Med Clin;11(3):365-78, 2016 Sep.
[Is] ISSN:1556-4088
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Central disorders of hypersomnolence are rare conditions with a poorly understood pathophysiology, making the identification and management challenging for sleep clinicians. Clinical history is essential for ruling out secondary causes of hypersomnolence and distinguishing among diagnoses. Current diagnostic criteria rely heavily on the polysomnogram and multiple sleep latency test. The current focus of treatment of hypersomnolence is on drugs that promote alertness. Additionally, in the case of narcolepsy type 1, medication management addresses control of cataplexy, the hallmark symptom of this disorder. Elucidation of pathophysiology of these disorders in the future will be essential to better categorization and management.
[Mh] Termos MeSH primário: Hipersonolência Idiopática/diagnóstico
Síndrome de Kleine-Levin/diagnóstico
Narcolepsia/diagnóstico
[Mh] Termos MeSH secundário: Seres Humanos
Hipersonolência Idiopática/tratamento farmacológico
Síndrome de Kleine-Levin/tratamento farmacológico
Narcolepsia/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170213
[Lr] Data última revisão:
170213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160821
[St] Status:MEDLINE


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[PMID]:27417057
[Au] Autor:Ferri R; Pizza F; Vandi S; Iloti M; Plazzi G
[Ad] Endereço:Department of Neurology I.C., IRCCS Oasi Institute for Research on Mental Retardation and Brain Aging, Troina, Italy. Electronic address: rferri@oasi.en.it.
[Ti] Título:Decreased sleep stage transition pattern complexity in narcolepsy type 1.
[So] Source:Clin Neurophysiol;127(8):2812-9, 2016 Aug.
[Is] ISSN:1872-8952
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To analyze the complexity of the nocturnal sleep stage sequence in central disorders of hypersomnolence (CDH), with the hypothesis that narcolepsy type 1 (NT1) might exhibit distinctive sleep stage sequence organization and complexity. METHODS: Seventy-nine NT1 patients, 22 narcolepsy type 2 (NT2), 22 idiopathic hypersomnia (IH), and 52 patients with subjective hypersomnolence (sHS) were recruited and their nocturnal sleep was polysomnographically recorded and scored. Group between-stage transition probability matrices were obtained and compared. RESULTS: Patients with NT1 differed significantly from all the other patient groups, the latter, in turn, were not different between each other. The individual probability of the R-to-N2 transition was found to be the parameter showing the difference of highest significance between the groups (lowest in NT1) and classified patients with or without NT1 with an accuracy of 78.9% (sensitivity 78.5% and specificity 79.2%), by applying a cut-off value of 0.15. CONCLUSIONS: The main result of this study is that the structure of the sleep stage transition pattern of hypocretin-deficient NT1 patients is significantly different from that of other forms of CDH and sHS, with normal hypocretin levels. SIGNIFICANCE: The lower probability of R-to-N2 transition occurrence in NT1 appears to be a reliable polysomnographic feature with potential application at the individual level, for supportive diagnostic purposes.
[Mh] Termos MeSH primário: Encéfalo/fisiopatologia
Distúrbios do Sono por Sonolência Excessiva/fisiopatologia
Hipersonolência Idiopática/fisiopatologia
Narcolepsia/fisiopatologia
Fases do Sono/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Polissonografia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170526
[Lr] Data última revisão:
170526
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160716
[St] Status:MEDLINE


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[PMID]:26895727
[Au] Autor:Sowa NA
[Ad] Endereço:Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC. Electronic address: nsowa@unch.unc.edu.
[Ti] Título:Idiopathic Hypersomnia and Hypersomnolence Disorder: A Systematic Review of the Literature.
[So] Source:Psychosomatics;57(2):152-64, 2016 Mar-Apr.
[Is] ISSN:1545-7206
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Hypersomnia is a common complaint in medical offices. Often patients are given psychiatric diagnoses, but a primary sleep disorder may be present. The new diagnosis of "hypersomnolence disorder" (HD) in the Diagnostic and Statistical Manual of Mental Disorders, fifth edition is a primary sleep disorder most similar to the diagnosis "idiopathic hypersomnia" (IH) in sleep literature and can be missed in psychiatric settings. METHODS: A systematic review of the computerized databases PubMed, EMBASE, Web of Science, and Psychinfo using the search criteria "idiopathic AND (hypersomnolence OR hypersomnia)," as well as "hypersomnolence disorder was conducted." Articles were included if they were in English and included information regarding the epidemiology, diagnosis, pathophysiology, or treatment of IH or HD. Where relevant, weighted means and 95% CI were calculated based on the number of subjects in each study. RESULTS: A total of 143 articles discussed IH, whereas no articles were found regarding HD. Most articles were review articles, prospective studies, or studies of pathophysiology. IH is found in approximately 0.02%-0.010% of the general population, has a mean age of onset of 21.8 years, and is associated with several somatic symptoms. Alterations in histaminergic or dopaminergic signaling may be involved in IH. Treatment with modafinil or other stimulants appears moderately effective. IH can be differentiated from psychiatric hypersomnolence by formal polysomnography. CONCLUSIONS: IH and HD are relatively uncommon disorders and little is known about them. However, they are distinct from psychiatric disorders and respond well to treatment once properly identified.
[Mh] Termos MeSH primário: Estimulantes do Sistema Nervoso Central/uso terapêutico
Distúrbios do Sono por Sonolência Excessiva/diagnóstico
Distúrbios do Sono por Sonolência Excessiva/tratamento farmacológico
[Mh] Termos MeSH secundário: Compostos Benzidrílicos/uso terapêutico
Seres Humanos
Hipersonolência Idiopática/diagnóstico
Hipersonolência Idiopática/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Benzhydryl Compounds); 0 (Central Nervous System Stimulants); R3UK8X3U3D (modafinil)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170130
[Lr] Data última revisão:
170130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160221
[St] Status:MEDLINE


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[PMID]:26864219
[Au] Autor:Kretzschmar U; Werth E; Sturzenegger C; Khatami R; Bassetti CL; Baumann CR
[Ad] Endereço:University Hospital, Zurich, Switzerland.
[Ti] Título:Which diagnostic findings in disorders with excessive daytime sleepiness are really helpful? A retrospective study.
[So] Source:J Sleep Res;25(3):307-13, 2016 Jun.
[Is] ISSN:1365-2869
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Due to extensive clinical and electrophysiological overlaps, the correct diagnosis of disorders with excessive daytime sleepiness is often challenging. The aim of this study was to provide diagnostic measures that help discriminating such disorders, and to identify parameters, which don't. In this single-center study, we retrospectively identified consecutive treatment-naïve patients who suffered from excessive daytime sleepiness, and analyzed clinical and electrophysiological measures in those patients in whom a doubtless final diagnosis could be made. Of 588 patients, 287 reported subjective excessive daytime sleepiness. Obstructive sleep apnea is the only disorder that could be identified by polysomnography alone. The diagnosis of insufficient sleep syndrome relies on actigraphy as patients underestimate their sleep need and the disorder shares several clinical and electrophysiological properties with both narcolepsy type 1 and idiopathic hypersomnia. Sleep stage sequencing on MSLT appears helpful to discriminate between insufficient sleep syndrome and narcolepsy. Sleep inertia is a strong indicator for idiopathic hypersomnia. There are no distinctive electrophysiological findings for the diagnosis of restless legs syndrome. Altogether, EDS disorders are common in neurological sleep laboratories, but usually cannot be diagnosed based on PSG and MSLT findings alone. The diagnostic value of actigraphy recordings can hardly be overestimated.
[Mh] Termos MeSH primário: Distúrbios do Sono por Sonolência Excessiva/diagnóstico
Distúrbios do Sono por Sonolência Excessiva/fisiopatologia
[Mh] Termos MeSH secundário: Actigrafia
Adulto
Feminino
Seres Humanos
Hipersonolência Idiopática/diagnóstico
Hipersonolência Idiopática/fisiopatologia
Masculino
Meia-Idade
Narcolepsia/diagnóstico
Narcolepsia/fisiopatologia
Polissonografia
Síndrome das Pernas Inquietas/diagnóstico
Síndrome das Pernas Inquietas/fisiopatologia
Estudos Retrospectivos
Apneia Obstrutiva do Sono/diagnóstico
Apneia Obstrutiva do Sono/fisiopatologia
Fases do Sono
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160212
[St] Status:MEDLINE
[do] DOI:10.1111/jsr.12383



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