Base de dados : MEDLINE
Pesquisa : C10.886.425.800.200.500 [Categoria DeCS]
Referências encontradas : 169 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 17 ir para página                         

  1 / 169 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28221196
[Au] Autor:Drouet C; Morel O; Verger A; Guedj E; Boulahdour H
[Ad] Endereço:From the *Department of Nuclear Medicine, University Hospital Jean Minjoz, Besançon; †University of Bourgogne Franche-Comté; ‡EA 4662-Nanomedicine Lab, Imagery and Therapeutics, Besançon; §Service de Médecine Nucléaire, CHU Brabois, Nancy; ∥Nancyclotep Imaging Platform, Nancy; ¶IADI, INSERM U947, Nancy; **Service Central de Biophysique et Médecine Nucléaire, Hôpital de la Timone, APHM, Marseille; ††Aix-Marseille Univ, INT, CNRS UMR 7289, Marseille; and ‡‡Aix-Marseille Univ, CERIMED, Marseille, France.
[Ti] Título:FDG Brain PET/CT Revealing Bilateral Thalamostriatal Activation During a Symptomatic Episode in a Patient With Kleine-Levin Syndrome.
[So] Source:Clin Nucl Med;42(5):e261-e262, 2017 May.
[Is] ISSN:1536-0229
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We report the case of a 14-year-old girl with clinically diagnosed Kleine-Levin syndrome. Electroencephalogram and brain MRI were unremarkable. An FDG PET/CT scan was acquired during a symptomatic episode, while she was asleep, and another PET scan was obtained when she was asymptomatic, awake, and quiet. Comparison of both examinations demonstrated a bilateral activation of thalami, caudate nuclei, and lenticular nuclei. These findings may be linked to the implication of thalamostriatal structures in the regulation of sleep and wakefulness.
[Mh] Termos MeSH primário: Encéfalo/diagnóstico por imagem
Síndrome de Kleine-Levin/diagnóstico por imagem
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
[Mh] Termos MeSH secundário: Adolescente
Feminino
Fluordesoxiglucose F18
Seres Humanos
Compostos Radiofarmacêuticos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170518
[Lr] Data última revisão:
170518
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170222
[St] Status:MEDLINE
[do] DOI:10.1097/RLU.0000000000001616


  2 / 169 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27542882
[Au] Autor:Berkowski JA; Shelgikar AV
[Ad] Endereço:Michael S. Aldrich Sleep Disorders Laboratory, Department of Neurology, University of Michigan, 1500 East Medical Center Drive, SPC 5845, C728 Med Inn Building, Ann Arbor, MI 48109-5845, USA. Electronic address: andyberk@med.umich.edu.
[Ti] Título:Disorders of Excessive Daytime Sleepiness Including Narcolepsy and Idiopathic Hypersomnia.
[So] Source:Sleep Med Clin;11(3):365-78, 2016 Sep.
[Is] ISSN:1556-4088
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Central disorders of hypersomnolence are rare conditions with a poorly understood pathophysiology, making the identification and management challenging for sleep clinicians. Clinical history is essential for ruling out secondary causes of hypersomnolence and distinguishing among diagnoses. Current diagnostic criteria rely heavily on the polysomnogram and multiple sleep latency test. The current focus of treatment of hypersomnolence is on drugs that promote alertness. Additionally, in the case of narcolepsy type 1, medication management addresses control of cataplexy, the hallmark symptom of this disorder. Elucidation of pathophysiology of these disorders in the future will be essential to better categorization and management.
[Mh] Termos MeSH primário: Hipersonolência Idiopática/diagnóstico
Síndrome de Kleine-Levin/diagnóstico
Narcolepsia/diagnóstico
[Mh] Termos MeSH secundário: Seres Humanos
Hipersonolência Idiopática/tratamento farmacológico
Síndrome de Kleine-Levin/tratamento farmacológico
Narcolepsia/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170213
[Lr] Data última revisão:
170213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160821
[St] Status:MEDLINE


  3 / 169 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:27364793
[Au] Autor:Luo YW; Yu H; Yuan LH; Zhu GX
[Ad] Endereço:Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China.
[Ti] Título:A Polysomnography Study of Kleine-Levin Syndrome in a Single Center.
[So] Source:Chin Med J (Engl);129(13):1565-8, 2016 Jul 05.
[Is] ISSN:0366-6999
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Kleine-Levin syndrome (KLS) is a rare sleep disorder characterized by recurrent episodes of hypersomnia. Polysomnographic (PSG) researches of KLS have been reported only in few publications in the past decades. This study aimed to investigate the characteristics of PSG of KLS. METHODS: This study, which was conducted from March 2010 to July 2014, included seven patients diagnosed with KLS in the Sleep and Wake Disorder Center of Huashan Hospital, Fudan University (Shanghai, China). PSG and multiple sleep latency tests (MSLT) were performed during their episodes and the results were evaluated. RESULTS: Five of the seven patients were males. The mean age at KLS onset was 15.6 ± 3.6 years. The number of episodes ranged from 2 to 7. The duration of episodes lasted from 4 to 11 days. The sleep architecture and proportion were normal in most of the patients. The average value of mean sleep latency was 6.9 ± 4.1 min. No sleep-onset rapid eye movement (SOREM) was detected in three of the patients, whereas one patient experienced one period of SOREM, and such episodes occurred twice in other two patients. CONCLUSIONS: We found that sleep architecture and proportion were normal in most KLS patients. However, the results of PSG and MSLT had no specificity for KLS patients.
[Mh] Termos MeSH primário: Síndrome de Kleine-Levin/diagnóstico
Síndrome de Kleine-Levin/fisiopatologia
Polissonografia/métodos
[Mh] Termos MeSH secundário: Adolescente
Criança
China
Feminino
Seres Humanos
Masculino
Estudos Retrospectivos
Transtornos do Sono-Vigília/fisiopatologia
Sono REM/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160702
[St] Status:MEDLINE
[do] DOI:10.4103/0366-6999.184476


  4 / 169 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27253765
[Au] Autor:Nguyen QT; Groos E; Leclair-Visonneau L; Monaca-Charley C; Rico T; Farber N; Mignot E; Arnulf I
[Ad] Endereço:National Reference Center for Narcolepsy, Idiopathic Hypersomnia and Kleine-Levin Syndrome, Sleep Disorders Unit and Hospital-University Institute of Neuroscience, Pitié-Salpêtrière Hospital (APHP), Pierre and Marie Curie University, Paris, France.
[Ti] Título:Familial Kleine-Levin Syndrome: A Specific Entity?
[So] Source:Sleep;39(8):1535-42, 2016 Aug 01.
[Is] ISSN:1550-9109
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:STUDY OBJECTIVES: Kleine-Levin syndrome (KLS) is a rare, mostly sporadic disorder, characterized by intermittent episodes of hypersomnia plus cognitive and behavior disorders. Although its cause is unknown, multiplex families have been described. We contrasted the clinical and biological features of familial versus sporadic KLS. METHODS: Two samples of patients with KLS from the United States and France (n = 260) were studied using clinical interviews and human leukocyte antigen (HLA) genotyping. A multiplex family contained two or more first- or second-degree affected relatives (familial cases). RESULTS: Twenty-one patients from 10 multiplex families (siblings: n = 12, including two pairs of monozygotic twins; parent-child: n = 4; cousins: n = 2; uncle-nephews: n = 3) and 239 patients with sporadic KLS were identified, yielding to 4% multiplex families and 8% familial cases. The simplex and multiplex families did not differ for autoimmune, neurological, and psychiatric disorders. Age, sex ratio, ethnicity, HLA typing, karyotyping, disease course, frequency, and duration of KLS episodes did not differ between groups. Episodes were less frequent in familial versus sporadic KLS (2.3 ± 1.8/y versus 3.8 ± 3.7/y, P = 0.004). Menses triggered more frequently KLS onset in the nine girls with familial KLS (relative risk, RR = 4.12, P = 0.03), but not subsequent episodes. Familial cases had less disinhibited speech (RR = 3.44, P = 0.049), less combined hypophagia/hyperphagia (RR = 4.38, P = 0.006), more abrupt termination of episodes (RR = 1.45, P = 0.04) and less postepisode insomnia (RR = 2.16, P = 0.008). There was similar HLA DQB1 distribution in familial versus sporadic cases and no abnormal karyotypes. CONCLUSION: Familial KLS is mostly present in the same generation, and is clinically similar to but slightly less severe than sporadic KLS.
[Mh] Termos MeSH primário: Síndrome de Kleine-Levin/classificação
Síndrome de Kleine-Levin/genética
[Mh] Termos MeSH secundário: Distúrbios do Sono por Sonolência Excessiva/complicações
Distúrbios do Sono por Sonolência Excessiva/genética
Saúde da Família
Feminino
França
Genótipo
Teste de Histocompatibilidade
Seres Humanos
Hiperfagia/complicações
Hiperfagia/genética
Síndrome de Kleine-Levin/complicações
Síndrome de Kleine-Levin/fisiopatologia
Masculino
Linhagem
Doenças Raras/complicações
Doenças Raras/genética
Doenças Raras/fisiopatologia
Distúrbios do Início e da Manutenção do Sono/complicações
Distúrbios do Início e da Manutenção do Sono/genética
Estados Unidos
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160603
[St] Status:MEDLINE
[do] DOI:10.5665/sleep.6014


  5 / 169 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27230978
[Au] Autor:Engström M; Landtblom AM; Karlsson T
[Ad] Endereço:Department of Medical and Health Sciences (IMH), Linköping University, Linköping, Sweden.
[Ti] Título:New hypothesis on pontine-frontal eye field connectivity in Kleine-Levin syndrome.
[So] Source:J Sleep Res;25(6):716-719, 2016 Dec.
[Is] ISSN:1365-2869
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Previous studies have indicated involvement of the thalamus and the pons in Kleine-Levin syndrome. In the present study, functional connectivity of the thalamus and the pons was investigated in asymptomatic patients with Kleine-Levin syndrome and healthy controls. Twelve patients and 14 healthy controls were investigated by functional magnetic resonance imaging during rest. Resting state images were analysed using seed regions of interest in the thalamus and the pons. The results showed significantly lower functional connectivity between the pons and the frontal eye field in persons with Kleine-Levin syndrome compared with healthy controls. There were no connectivity differences involving the thalamus. Based on these findings, a relation is proposed between the sleep disorder Kleine-Levin syndrome and cerebral control of eye movements, which in turn is related to visual attention and working memory. This hypothesis has to be tested in future studies of oculomotor control in Kleine-Levin syndrome.
[Mh] Termos MeSH primário: Movimentos Oculares/fisiologia
Lobo Frontal/fisiopatologia
Síndrome de Kleine-Levin/fisiopatologia
Modelos Neurológicos
Ponte/fisiopatologia
[Mh] Termos MeSH secundário: Adolescente
Atenção/fisiologia
Estudos de Casos e Controles
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Memória de Curto Prazo/fisiologia
Descanso
Tálamo/fisiopatologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160528
[St] Status:MEDLINE
[do] DOI:10.1111/jsr.12428


  6 / 169 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Texto completo
[PMID]:27153153
[Au] Autor:de Oliveira MM; Conti C; Prado GF
[Ad] Endereço:Universidade Federal de São Paulo, Rua Pedro de Toledo, 598, São Paulo, São Paulo, Brazil, 04039-001.
[Ti] Título:Pharmacological treatment for Kleine-Levin syndrome.
[So] Source:Cochrane Database Syst Rev;(5):CD006685, 2016 May 06.
[Is] ISSN:1469-493X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This is an updated version of the original Cochrane review, published in 2009, Issue 2.Kleine-Levin syndrome (KLS) is a rare disorder that mainly affects adolescent men. It is characterised by recurrent episodes of hypersomnia, usually accompanied by hyperphagia, cognitive and mood disturbances, abnormal behaviour, such as hypersexuality, and signs of dysautonomia.In 1990, the diagnostic criteria for Kleine-Levin syndrome were modified in the International Classification of Sleep Disorders, where KLS was defined as a syndrome comprised of recurring episodes of undue sleepiness lasting some days, which may or may not be associated with hyperphagia and abnormal behaviour. According to the International Classification of Sleepiness Disorders, 3rd version (ICSD-3), revised in 2014, the Kleine-Levin syndrome is a disorder characterized by recurrent episodes of hypersomnia that last from two days to four weeks, with at least annual recurrence, and hyperphagia (rapid consumption of a large amount of food), usually with onset in early adolescence in males but occasionally in later life and in women. A monosymptomatic form of the disorder with hypersomnia only can occur without binge eating or hypersexuality.The cause of Kleine-Levin syndrome remains unknown, and several treatment strategies have been used. Some medications have been reported to provide benefit in the treatment of patients with KLS, but because of the rarity of the condition, no long-term follow-up therapies have yet been described. OBJECTIVES: This review aimed to evaluate:1. whether pharmacological treatment for Kleine Levin syndrome was effective and safe.2. which drug or category of drugs was effective and safe. SEARCH METHODS: For the latest update, we searched the following sources: the Cochrane Epilepsy Group Specialized Register (7 April 2016); the Cochrane Central Register of Controlled Trials (CENTRAL) via the Cochrane Register of Studies Online CRSO (7 April 2016); MEDLINE (1946 to April 2016); LILACS (7 April 2016); ClinicalTrials.gov (7 April 2016); WHO International Clinical Trials Registry Platform ICTRP (7 April 2016); reference lists of sleep medicine textbooks; review articles and reference lists of articles identified by the search strategies. SELECTION CRITERIA: All randomised controlled trials (RCTs) and quasi-randomised controlled trials looking at pharmacological interventions for Kleine-Levin syndrome were eligible. We had planned to include both parallel-group and cross-over studies. DATA COLLECTION AND ANALYSIS: Two review authors (MMO and CC) had planned to extract the data reported in the original articles. MAIN RESULTS: No studies met the inclusion criteria for this systematic review. AUTHORS' CONCLUSIONS: Therapeutic trials of pharmacological treatment for Kleine-Levin syndrome with a double-blind, placebo-controlled design are needed.
[Mh] Termos MeSH primário: Síndrome de Kleine-Levin/tratamento farmacológico
Doenças Raras/tratamento farmacológico
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160601
[Lr] Data última revisão:
160601
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160507
[St] Status:MEDLINE
[do] DOI:10.1002/14651858.CD006685.pub4


  7 / 169 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27137943
[Au] Autor:Miglis MG; Guilleminault C
[Ad] Endereço:Sleep Medicine, Stanford University, Redwood City, CA, USA. mmiglis@stanford.edu.
[Ti] Título:Kleine-Levin Syndrome.
[So] Source:Curr Neurol Neurosci Rep;16(6):60, 2016 Jun.
[Is] ISSN:1534-6293
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Kleine-Levin syndrome is a rare recurrent hypersomnia associated with symptoms of behavioral and cognitive impairment. This article reviews common presenting symptoms, differential diagnosis, diagnostic workup, and potential treatment options. Current updates on functional imaging studies and long-term neuropsychological studies are reviewed.
[Mh] Termos MeSH primário: Síndrome de Kleine-Levin
[Mh] Termos MeSH secundário: Animais
Diagnóstico Diferencial
Fenômenos Eletrofisiológicos
Seres Humanos
Síndrome de Kleine-Levin/diagnóstico
Síndrome de Kleine-Levin/epidemiologia
Síndrome de Kleine-Levin/fisiopatologia
Testes Neuropsicológicos
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1612
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160504
[St] Status:MEDLINE
[do] DOI:10.1007/s11910-016-0653-6


  8 / 169 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26943469
[Au] Autor:Wang JY; Han F; Dong SX; Li J; An P; Zhang XZ; Chang Y; Zhao L; Zhang XL; Liu YN; Yan H; Li QH; Hu Y; Lv CJ; Gao ZC; Strohl KP
[Ad] Endereço:Binzhou Medical University Hospital, Shandong Province, China.
[Ti] Título:Cerebrospinal Fluid Orexin A Levels and Autonomic Function in Kleine-Levin Syndrome.
[So] Source:Sleep;39(4):855-60, 2016 Apr 01.
[Is] ISSN:1550-9109
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:STUDY OBJECTIVES: Kleine-Levin syndrome (KLS) is a rare disorder of relapsing sleepiness. The hypothesis was that the syndrome is related to a change in the vigilance peptide orexin A. METHODS: From 2002 to 2013, 57 patients with relapsing hypersomnolence were clinically assessed in a referral academic center in Beijing, China, and 44 (28 males and 16 females; mean age 18.3 ± 8.9 y (mean ± standard deviation, range 9-57 y) were determined to have clinical and behavioral criteria consistent with KLS. Cerebrospinal fluid orexin A levels and diurnal blood pressure were measured in relapse versus remission in a subgroup of patients. RESULTS: Presenting symptoms included relapsing or remitting excessive sleepiness-associated parallel complaints of cognitive changes (82%), eating disorders (84%); depression (45%); irritability (36%); hypersexuality (18%); and compulsions (11%). Episodes were 8.2 ± 3.3 days in duration. In relapse, diurnal values for blood pressure and heart rate were lower (P < 0.001). In a subgroup (n = 34), cerebrospinal fluid orexin A levels were ∼31% lower in a relapse versus remission (215.7 ± 81.5 versus 319.2 ± 95.92 pg/ml, P < 0.001); in three patients a pattern of lower levels during subsequent relapses was documented. CONCLUSIONS: There are lower orexin A levels in the symptomatic phase than in remission and a fall and rise in blood pressure and heart rate, suggesting a role for orexin dysregulation in KLS pathophysiology.
[Mh] Termos MeSH primário: Pressão Sanguínea
Frequência Cardíaca
Síndrome de Kleine-Levin/líquido cefalorraquidiano
Síndrome de Kleine-Levin/fisiopatologia
Orexinas/líquido cefalorraquidiano
[Mh] Termos MeSH secundário: Adolescente
Adulto
Pequim
Criança
Feminino
Seres Humanos
Masculino
Meia-Idade
Recidiva
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Orexins)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160305
[St] Status:MEDLINE
[do] DOI:10.5665/sleep.5642


  9 / 169 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26935190
[Au] Autor:Arnone JM; Conti RP
[Ti] Título:Kleine-Levin Syndrome: An Overview and Relevance to Nursing Practice.
[So] Source:J Psychosoc Nurs Ment Health Serv;54(3):41-7, 2016 Mar.
[Is] ISSN:0279-3695
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Kleine-Levin syndrome (KLS) is a neuropsychiatric sleep disorder primarily affecting adolescent males. Onset is insidious, idiopathic, and hastened by neurological incident or infection. Typically, the initial onset occurs during the teen years or after the second decade, although cases have been documented in early childhood, adulthood, and senescence. KLS is marked by unexpected debilitating, yet reversible, episodic hypersomnia, with varying recurrence rates; cognitive and behavioral impairment; compulsive eating; and feelings of derealization, hypersexuality, apathy, and depressed mood. Diagnosis is problematic due to the syndrome's rarity, disparity of presenting clinical symptoms, and misdiagnosis. Correct diagnosis can take up to 4 years. The clinical course is approximately 8 to 14 years from initial onset, yet may be longer in the adult form of the disorder. KLS has been shown to impact activities of daily living, usurping an adolescent of his/her social relations with peers, experiences, and time.
[Mh] Termos MeSH primário: Síndrome de Kleine-Levin
[Mh] Termos MeSH secundário: Atividades Cotidianas
Adolescente
Transtornos Cognitivos
Diagnóstico Diferencial
Seres Humanos
Síndrome de Kleine-Levin/complicações
Síndrome de Kleine-Levin/diagnóstico
Síndrome de Kleine-Levin/enfermagem
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM; N
[Da] Data de entrada para processamento:160304
[St] Status:MEDLINE
[do] DOI:10.3928/02793695-20160219-07


  10 / 169 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:26739970
[Au] Autor:Al Suwayri SM
[Ad] Endereço:Department of Internal Medicine, College of Medicine, Al-Imam Muhammed Ibn Saud University, Riyadh, Kingdom of Saudi Arabia. E-mail. drsaad321@hotmail.com.
[Ti] Título:Kleine-Levin syndrome. Familial cases and comparison with sporadic cases.
[So] Source:Saudi Med J;37(1):21-8, 2016 Jan.
[Is] ISSN:0379-5284
[Cp] País de publicação:Saudi Arabia
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To highlight the occurrence of familial cases and addresses, whether familial Kleine-Levine syndrome (KLS) presents the same spectrum of disease, as that seen in sporadic KLS.   METHODS: Between September and December 2014, reports of familial cases of KLS were identified by searching the Library of Congress, PubMed, and Web of Science databases restricted to the English language, with no restriction on date of publication. All cases were reviewed to identify familial cases consistent with current diagnostic criteria for sporadic KLS.   RESULTS: Six reviews and 11 case reports describing cases of familial KLS were identified. In 17 of the 29 familial cases identified, sufficient clinical details were described to be confident that these cases were familial and consistent with the description of KLS in the International Classification of Sleep Disorders 3rd edition (ICSD-3), and recent detailed reviews of sporadic KLS. CONCLUSION: A significant number of familial cases of KLS have been described that are consistent with the ICSD-3 description of KLS, and indistinguishable from sporadic KLS. This suggests that study of familial KLS using modern genetic techniques may be useful in elucidating the pathogenesis of this rare condition.
[Mh] Termos MeSH primário: Síndrome de Kleine-Levin/fisiopatologia
[Mh] Termos MeSH secundário: Predisposição Genética para Doença
Seres Humanos
Classificação Internacional de Doenças
Síndrome de Kleine-Levin/genética
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160108
[St] Status:MEDLINE
[do] DOI:10.15537/smj.2016.1.12992



página 1 de 17 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde