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[PMID]:28364570
[Au] Autor:Nepozitek J; Sonka K
[Ad] Endereço:Centre for Sleep and Wake Disorders, Department of Neurology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic. jiri.nepozitek@lf1.cuni.cz.
[Ti] Título:Excessive Fragmentary Myoclonus: What Do We Know?
[So] Source:Prague Med Rep;118(1):5-13, 2017.
[Is] ISSN:1214-6994
[Cp] País de publicação:Czech Republic
[La] Idioma:eng
[Ab] Resumo:Excessive fragmentary myoclonus (EFM) is a polysomnographic finding registered by the surface electromyography (EMG) and characterized as a result of the muscle activity consisting of sudden, isolated, arrhythmic, asynchronous and asymmetric brief twitches. The EMG potentials are defined by the exact criteria in The International Classification of the Sleep Disorders, 3rd edition and they appear with high intensity in all sleep stages. Clinical significance of EFM is unclear. It was observed in combination with other diseases and features such as obstructive and central sleep apnea, narcolepsy, periodic limb movements, insomnia, neurodegenerative disorders and peripheral nerve dysfunction. Relation to such wide range of diseases supports the opinion that EFM is nor a specific sleep disorder nor a specific polysomnographic sign. The option that EFM is a normal variant has also not been ruled out so far.
[Mh] Termos MeSH primário: Síndrome da Mioclonia Noturna/fisiopatologia
[Mh] Termos MeSH secundário: Eletromiografia
Seres Humanos
Polissonografia
Fatores de Risco
Fases do Sono
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170402
[St] Status:MEDLINE
[do] DOI:10.14712/23362936.2017.1


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[PMID]:28364468
[Au] Autor:Hiranniramol K; Fulda S; Skeba P; Earley CJ; Allen RP
[Ad] Endereço:Center for Restless Legs Study, Department of Neurology, Johns Hopkins University, Baltimore, MD.
[Ti] Título:Intervening Leg Movements Disrupt PLMS Sequences.
[So] Source:Sleep;40(1), 2017 Jan 01.
[Is] ISSN:1550-9109
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Study Objectives: Periodic leg movements during sleep (PLMS) occur within a subject as a series with a remarkably stable period defined by the intermovement interval (IMI). Sometimes a non-PLMS movement occurs intervening between two PLMS. PLMS scoring rules totally ignore these intervening leg movements (iLM). This implicitly assumes an iLM results from a process sufficiently independent from the periodic process producing PLMS that it does not affect the periodicity of the surrounding PLMS. This study for the first time tests this basic assumption and explores characteristics of iLM as a potentially significant class of leg movements during sleep. Methods: Leg movements were analyzed from two nights of polysomnography recordings from 27 RLS patients and 22 controls using the validated MATPLM1.1 program. All periods (IMI) between PLMS containing an iLM were compared to the local PLMS period defined as the immediately preceding PLMS IMI using pairwise two-sided Wilcoxon sign-rank tests. Similarly, iLM were tested to see if they started a new PLMS series by having the same period as the subsequent PLMS. Results: The periods (IMIs) containing iLM were longer than the previous periods in RLS subjects, but not controls (p < .05). The periods beginning with the iLM were shorter than the subsequent periods in both RLS and controls (p < .05). Conclusions: iLM as a separate type of LM distort PLMS periodicity and do not restart PLMS series. iLM end PLMS series.
[Mh] Termos MeSH primário: Síndrome da Mioclonia Noturna/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Estudos de Casos e Controles
Feminino
Seres Humanos
Masculino
Meia-Idade
Síndrome da Mioclonia Noturna/diagnóstico
Periodicidade
Polissonografia
Sono/fisiologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170402
[St] Status:MEDLINE
[do] DOI:10.1093/sleep/zsw023


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[PMID]:28364416
[Au] Autor:Gaig C; Iranzo A; Pujol M; Perez H; Santamaria J
[Ad] Endereço:Neurology Service and Multidisciplinary Sleep Unit, Hospital Clínic of Barcelona, Barcelona 08036, Spain.
[Ti] Título:Periodic Limb Movements During Sleep Mimicking REM Sleep Behavior Disorder: A New Form of Periodic Limb Movement Disorder.
[So] Source:Sleep;40(3), 2017 Mar 01.
[Is] ISSN:1550-9109
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Study Objectives: To describe a group of patients referred because of abnormal sleep behaviors that were suggestive of rapid eye movement (REM) sleep behavior disorder (RBD) in whom video-polysomnography ruled out RBD and showed the reported behaviors associated with vigorous periodic limb movements during sleep (PLMS). Aims and Methods: Clinical history and video-polysomnography review of patients identified during routine visits in a sleep center. Results: Patients were 15 men and 2 women with a median age of 66 (range: 48-77) years. Reported sleep behaviors were kicking (n = 17), punching (n = 16), gesticulating (n = 8), falling out of bed (n = 5), assaulting the bed partner (n = 2), talking (n = 15), and shouting (n = 10). Behaviors resulted in injuries in 3 bed partners and 1 patient. Twelve (70.6%) patients were not aware of displaying abnormal sleep behaviors that were only noticed by their bed partners. Ten (58.8%) patients recalled unpleasant dreams such as being attacked or chased. Video-polysomnography showed (1) frequent and vigorous stereotyped PLMS involving the lower limbs, upper limbs, and trunk (median PLMS index 61.2; median PLMS index in NREM sleep 61.9; during REM sleep only 8 patients had PLMS and their median PLMS index in REM sleep was 39.5); (2) abnormal behaviors (e.g., punching, groaning) during some of the arousals that immediately followed PLMS in NREM sleep; and (3) ruled out RBD and other sleep disorders such as obstructive sleep apnea. Dopaminergic agents were prescribed in 14 out of the 17 patients and resulted in improvement of abnormal sleep behaviors and unpleasant dreams in all of them. After dopaminergic treatment, follow-up video-polysomnography in 7 patients showed a decrease in the median PLMS index from baseline (108.9 vs. 19.2, p = .002) and absence of abnormal behaviors during the arousals. Conclusions: Abnormal sleep behaviors and unpleasant dreams simulating RBD symptomatology may occur in patients with severe PLMS. In these cases, video-polysomnography ruled out RBD and identified prominent PLMS followed by arousals containing abnormal behaviors. Our cases represent an objectively documented subtype of periodic limb movement disorder causing abnormal sleep behaviors.
[Mh] Termos MeSH primário: Síndrome da Mioclonia Noturna/diagnóstico
Síndrome da Mioclonia Noturna/fisiopatologia
Polissonografia/métodos
Transtorno do Comportamento do Sono REM/diagnóstico
Transtorno do Comportamento do Sono REM/fisiopatologia
[Mh] Termos MeSH secundário: Idoso
Nível de Alerta/fisiologia
Diagnóstico Diferencial
Feminino
Seres Humanos
Masculino
Meia-Idade
Movimento/fisiologia
Síndrome da Mioclonia Noturna/epidemiologia
Transtorno do Comportamento do Sono REM/epidemiologia
Sono REM/fisiologia
Gravação em Vídeo/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170402
[St] Status:MEDLINE
[do] DOI:10.1093/sleep/zsw063


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[PMID]:28329254
[Au] Autor:Boulos MI; Murray BJ; Muir RT; Gao F; Szilagyi GM; Huroy M; Kiss A; Walters AS; Black SE; Lim AS; Swartz RH
[Ad] Endereço:L.C. Campbell Cognitive Neurology Research Unit, Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Hurvitz Brain Sciences Research Program, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
[Ti] Título:Periodic Limb Movements and White Matter Hyperintensities in First-Ever Minor Stroke or High-Risk Transient Ischemic Attack.
[So] Source:Sleep;40(3), 2017 Mar 01.
[Is] ISSN:1550-9109
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Study Objectives: Emerging evidence suggests that periodic limb movements (PLMs) may contribute to the development of cerebrovascular disease. White matter hyperintensities (WMHs), a widely accepted biomarker for cerebral small vessel disease, are associated with incident stroke and death. We evaluated the association between increased PLM indices and WMH burden in patients presenting with stroke or transient ischemic attack (TIA), while controlling for vascular risk factors and stroke severity. Methods: Thirty patients presenting within 2 weeks of a first-ever minor stroke or high-risk TIA were prospectively recruited. PLM severity was measured with polysomnography. WMH burden was quantified using the Age Related White Matter Changes (ARWMC) scale based on neuroimaging. Partial Spearman's rank-order correlations and multiple linear regression models tested the association between WMH burden and PLM severity. Results: Greater WMH burden was correlated with elevated PLM index and stroke volume. Partial Spearman's rank-order correlations demonstrated that the relationship between WMH burden and PLM index persisted despite controlling for vascular risk factors. Multivariate linear regression models revealed that PLM index was a significant predictor of an elevated ARWMC score while controlling for age, stroke volume, stroke severity, hypertension, and apnea-hypopnea index. Conclusion: The quantity of PLMs was associated with WMH burden in patients with first-ever minor stroke or TIA. PLMs may be a risk factor for or marker of WMH burden, even after considering vascular risk factors and stroke severity. These results invite further investigation of PLMs as a potentially useful target to reduce WMH and stroke burden.
[Mh] Termos MeSH primário: Ataque Isquêmico Transitório/complicações
Síndrome da Mioclonia Noturna/patologia
Síndrome da Mioclonia Noturna/fisiopatologia
Acidente Vascular Cerebral/complicações
Substância Branca/patologia
[Mh] Termos MeSH secundário: Idoso
Biomarcadores
Feminino
Seres Humanos
Hipertensão/complicações
Hipertensão/patologia
Hipertensão/fisiopatologia
Ataque Isquêmico Transitório/patologia
Ataque Isquêmico Transitório/fisiopatologia
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Movimento
Síndrome da Mioclonia Noturna/complicações
Fatores de Risco
Acidente Vascular Cerebral/patologia
Acidente Vascular Cerebral/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE
[do] DOI:10.1093/sleep/zsw080


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[PMID]:28329227
[Au] Autor:Kendzerska T; Kamra M; Murray BJ; Boulos MI
[Ad] Endereço:Department of Medicine, University of Toronto, ON, Canada.
[Ti] Título:Incident Cardiovascular Events and Death in Individuals With Restless Legs Syndrome or Periodic Limb Movements in Sleep: A Systematic Review.
[So] Source:Sleep;40(3), 2017 Mar 01.
[Is] ISSN:1550-9109
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Study Objectives: To systematically review the current evidence examining restless legs syndrome (RLS) and periodic limb movements in sleep (PLMS) as prognostic factors for all-cause mortality and incident cardiovascular events (CVE) in longitudinal studies published in the adult population. Methods: All English language studies (from 1947 to 2016) found through Medline and Embase, as well as bibliographies of identified articles, were considered eligible. Quality was evaluated using published guidelines. Results: Among 18 cohorts (reported in 13 manuscripts), 15 evaluated the association between RLS and incident CVE and/or all-cause mortality and 3 between PLMS and CVE and mortality. The follow-up periods ranged from 2 to 20 years. A significant relationship between RLS and CVE was reported in four cohorts with a greater risk suggested for severe RLS with longer duration and secondary forms of RLS. Although a significant association between RLS and all-cause mortality was reported in three cohorts, a meta-analysis we conducted of the four studies of highest quality found no association (pooled hazard ratio = 1.09, 95% confidence interval: 0.80-1.78). A positive association between PLMS and CVE and/or mortality was demonstrated in all included studies with a greater risk attributed to PLMS with arousals. Conclusions: The available evidence on RLS as a prognostic factor for incident CVE and all-cause mortality was limited and inconclusive; RLS duration, severity, and secondary manifestations may be important in understanding a possible relationship. Although very limited, the current evidence suggests that PLMS may be a prognostic factor for incident CVE and mortality.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/epidemiologia
Doenças Cardiovasculares/mortalidade
Síndrome da Mioclonia Noturna/epidemiologia
Síndrome das Pernas Inquietas/epidemiologia
Sono
[Mh] Termos MeSH secundário: Estudos de Coortes
Seres Humanos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE
[do] DOI:10.1093/sleep/zsx013


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[PMID]:27457202
[Au] Autor:Athavale Y; Krishnan S; Dopsa DD; Berneshawi AG; Nouraei H; Raissi A; Murray BJ; Boulos MI
[Ad] Endereço:Department of Electrical & Computer Engineering, Ryerson University, Toronto, Canada.
[Ti] Título:Advanced signal analysis for the detection of periodic limb movements from bilateral ankle actigraphy.
[So] Source:J Sleep Res;26(1):14-20, 2017 Feb.
[Is] ISSN:1365-2869
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Actigraphy can assist in the detection of periodic limb movements in sleep. Although several actigraphs have been previously reported to accurately detect periodic limb movements, many are no longer available; of the existing actigraphs, most sample too infrequently to accurately detect periodic limb movements. The purpose of this study was to use advanced signal analysis to validate a readily available actigraph that has the capability of sampling at relatively high frequencies. We simultaneously recorded polysomnography and bilateral ankle actigraphy in 96 consecutive patients presenting to our sleep laboratory. After pre-processing and conditioning, the bilateral ankle actigraphy signals were then analysed for 14 simple time, frequency and morphology-based features. These features reduced the signal dimensionality and aided in better representation of the periodic limb movement activity in the actigraph signals. These features were then processed by a Naïve-Bayes binary classifier for distinguishing between normal and abnormal periodic limb movement indices. We trained the Naïve-Bayes classifier using a training set, and subsequently tested its classification accuracy using a testing set. From our experiments, using a periodic limb movement index cut-off of 5, we found that the Naïve-Bayes classifier had a correct classification rate of 78.9%, with a sensitivity of 80.3% and a specificity of 73.7%. The algorithm developed in this study has the potential of facilitating identification of periodic limb movements across a wide spectrum of patient populations via the use of bilateral ankle actigraphy.
[Mh] Termos MeSH primário: Actigrafia/métodos
Tornozelo/inervação
Síndrome da Mioclonia Noturna/diagnóstico
Polissonografia/métodos
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160727
[St] Status:MEDLINE
[do] DOI:10.1111/jsr.12438


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[PMID]:27027974
[Au] Autor:Lo Coco D; Puligheddu M; Mattaliano P; Congiu P; Borghero G; Fantini ML; La Bella V; Ferri R
[Ad] Endereço:ALS Clinical Research Center, Department of Biomedicine and Clinical Neurosciences, University of Palermo, Palermo, Italy.
[Ti] Título:REM sleep behavior disorder and periodic leg movements during sleep in ALS.
[So] Source:Acta Neurol Scand;135(2):219-224, 2017 Feb.
[Is] ISSN:1600-0404
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To assess sleep characteristics and the occurrence of abnormal muscle activity during sleep, such as REM sleep without atonia (RSWA), REM sleep behavior disorder (RBD), and periodic leg movements during sleep (PLMS), in patients with amyotrophic lateral sclerosis (ALS). METHODS: A total of 41 patients with ALS and 26 healthy subjects were submitted to clinical interview and overnight video-polysomnography. RESULTS: A total of 22 patients with ALS (53.6%) reported poor sleep quality. Polysomnographic studies showed that patients with ALS had reduced total sleep time, increased wakefulness after sleep onset, shortened REM and slow-wave sleep, and decreased sleep efficiency, compared to controls. Polysomnographic abnormalities were not different in patients reporting good or poor sleep and were not correlated to clinical and demographic variables. The PLMS index was significantly higher in patients with ALS than in healthy subjects, and 22 patients (53.6%) showed a PLMS index > 15/h, vs 4 (15.4%) controls (P < 0.001). Finally, two patients with ALS (4.9%) had RBD, and two more patients presented RSWA (4.9%), whereas no controls showed abnormalities of REM sleep. CONCLUSION: Patients with ALS frequently present abnormalities of sleep that can be documented both at the clinical interview and at the polysomnographic evaluation, including insomnia, fragmented sleep, and increased PLMS. Moreover, abnormalities of REM sleep can be found in some of these patients.
[Mh] Termos MeSH primário: Esclerose Amiotrófica Lateral/diagnóstico
Esclerose Amiotrófica Lateral/epidemiologia
Síndrome da Mioclonia Noturna/diagnóstico
Síndrome da Mioclonia Noturna/epidemiologia
Transtorno do Comportamento do Sono REM/diagnóstico
Transtorno do Comportamento do Sono REM/epidemiologia
Fases do Sono/fisiologia
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Itália/epidemiologia
Masculino
Meia-Idade
Polissonografia/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160331
[St] Status:MEDLINE
[do] DOI:10.1111/ane.12593


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[PMID]:26932899
[Au] Autor:Woo HG; Lee D; Hwang KJ; Ahn TB
[Ad] Endereço:Department of Neurology, College of Medicine, Kyung Hee University, Seoul, Korea.
[Ti] Título:Post-stroke restless leg syndrome and periodic limb movements in sleep.
[So] Source:Acta Neurol Scand;135(2):204-210, 2017 Feb.
[Is] ISSN:1600-0404
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Primary restless leg syndrome (RLS) and periodic limb movements in sleep (PLMS) frequently co-exist, obscuring the boundaries between the two conditions. In such instances, a study of secondary cases with focal lesions such as post-stroke RLS and PLMS (psRLS and psPLMS, respectively) can be helpful in identifying characteristics of the individual conditions. MATERIALS AND METHODS: Patients who had suffered strokes and who subsequently developed psRLS or psPLMS were recruited. To determine the overall features of psRLS/PLMS, historical cases were selected from the literature. All cases with either psRLS or psPLMS alone were further analyzed to elucidate the distinctive pathomechanisms of the two conditions. RESULTS: Six patients with either psRLS or psPLMS were recruited from our hospital; two patients had both conditions contemporaneously. The literature contains details on 30 cases of psRLS or psPLMS. The causative lesion was most frequently located in the pons. We found that psRLS was more often bilateral, and usually detected later in time. Lesions in both the pontine base and tegmentum (together) were associated with unilateral psPLMS, whereas lesions in the corona radiata and adjacent basal ganglia were associated with bilateral RLS. Lesions confined to the corona radiata resulted in either unilateral or bilateral RLS. CONCLUSIONS: The observed differences in the clinical and radiological features of psRLS and psPLMS suggest that the pathophysiologies of the two conditions are distinct. Further research is needed to understand the pathophysiologies of primary RLS and PLMS.
[Mh] Termos MeSH primário: Síndrome da Mioclonia Noturna/fisiopatologia
Síndrome das Pernas Inquietas/fisiopatologia
Sono/fisiologia
Acidente Vascular Cerebral/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Meia-Idade
Síndrome da Mioclonia Noturna/diagnóstico por imagem
Síndrome da Mioclonia Noturna/epidemiologia
Polissonografia/tendências
Ponte/diagnóstico por imagem
Síndrome das Pernas Inquietas/diagnóstico por imagem
Síndrome das Pernas Inquietas/epidemiologia
Estudos Retrospectivos
Acidente Vascular Cerebral/diagnóstico por imagem
Acidente Vascular Cerebral/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160303
[St] Status:MEDLINE
[do] DOI:10.1111/ane.12582


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[PMID]:27810014
[Au] Autor:Shangold L
[Ad] Endereço:ENT and Allergy Associates, 1500 Route 112, Port Jefferson Station, NY 11776, USA. Electronic address: Lshangold@entandallergy.com.
[Ti] Título:How to Evaluate a Diagnostic Sleep Study Report.
[So] Source:Otolaryngol Clin North Am;49(6):1307-1329, 2016 Dec.
[Is] ISSN:1557-8259
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There is more information on a sleep study report than just the Apnea-Hypopnea Index or Respiratory Disturbance Index. This article explains how to evaluate any sleep study report to get the most information out of it. Maximum information allows the optimal treatment of patients with obstructive sleep apnea and some other sleep disorders.
[Mh] Termos MeSH primário: Polissonografia
Apneia Obstrutiva do Sono/diagnóstico
[Mh] Termos MeSH secundário: Eletroencefalografia
Eletromiografia
Eletroculografia
Seres Humanos
Síndrome da Mioclonia Noturna/diagnóstico
Fenômenos Fisiológicos Respiratórios
Privação do Sono/diagnóstico
Fases do Sono
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170322
[Lr] Data última revisão:
170322
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161105
[St] Status:MEDLINE


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[PMID]:27568800
[Au] Autor:Leng Y; Blackwell T; Stone KL; Hoang TD; Redline S; Yaffe K
[Ad] Endereço:Department of Psychiatry, University of California, San Francisco, CA.
[Ti] Título:Periodic Limb Movements in Sleep are Associated with Greater Cognitive Decline in Older Men without Dementia.
[So] Source:Sleep;39(10):1807-1810, 2016 Oct 01.
[Is] ISSN:1550-9109
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:STUDY OBJECTIVES: To examine the association between periodic limb movements in sleep (PLMS) and change in selected aspects of cognition in community-dwelling older men. METHODS: We studied 2,636 older men without dementia who underwent in-home polysomnography with measurement of the periodic limb movement index (PLMI) and periodic limb movement arousal index (PLMAI) using piezoelectric sensors. Random-effects models and logistic regression were used to examine the association between PLMI, PLMAI, and 3- to 4-y change in cognition. RESULTS: After multivariable adjustment, men with a high PLMI had greater decline on the Trail Making Test - Part B (P trend = 0.02); those with a PLMI ≥ 30 were 48% more likely (odds ratio = 1.48, 95% confidence interval = 1.05-2.07) to experience the development of significant cognitive impairment (≥ 1 SD above mean change). Further adjustment for sleep efficiency, nocturnal hypoxemia, or dopaminergic medication use and analysis among men without Parkinson disease (n = 2,607) showed similar findings. No significant association was found for PLMAI or for Modified Mini-Mental State Examination scores. CONCLUSIONS: Among older men without dementia, higher PLMS frequency was associated with greater decline in cognition, particularly in executive function.
[Mh] Termos MeSH primário: Disfunção Cognitiva/diagnóstico
Disfunção Cognitiva/epidemiologia
Demência/diagnóstico
Demência/epidemiologia
Síndrome da Mioclonia Noturna/diagnóstico
Síndrome da Mioclonia Noturna/epidemiologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Disfunção Cognitiva/fisiopatologia
Demência/fisiopatologia
Seres Humanos
Vida Independente
Masculino
Testes Neuropsicológicos
Síndrome da Mioclonia Noturna/fisiopatologia
Polissonografia/métodos
Estudos Prospectivos
Sono/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160830
[St] Status:MEDLINE



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde