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[PMID]:27778395
[Au] Autor:Michailidou I; Naessens DM; Hametner S; Guldenaar W; Kooi EJ; Geurts JJ; Baas F; Lassmann H; Ramaglia V
[Ad] Endereço:Department of Genome Analysis, Academic Medical Center, Meibergdreef 9, Amsterdam, 1105, The Netherlands.
[Ti] Título:Complement C3 on microglial clusters in multiple sclerosis occur in chronic but not acute disease: Implication for disease pathogenesis.
[So] Source:Glia;65(2):264-277, 2017 02.
[Is] ISSN:1098-1136
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Microglial clusters with C3d deposits are observed in the periplaque of multiple sclerosis (MS) brains and were proposed as early stage of lesion formation. As such they should appear in the brain of MS donors with acute disease but thus far this has not been shown. Using postmortem brain tissue from acute (n = 10) and chronic (n = 15) MS cases we investigated whether C3d+ microglial clusters are part of an acute attack against myelinated axons, which could have implications for disease pathogenesis. The specificity of our findings to MS was tested in ischemic stroke cases (n = 8) with initial or advanced lesions and further analyzed in experimental traumatic brain injury (TBI, n = 26), as both conditions are primarily nondemyelinating but share essential features of neurodegeneration with MS lesions. C3d+ microglial clusters were found in chronic but not acute MS. They were not associated with antibody deposits or terminal complement activation. They were linked to slowly expanding lesions, localized on axons with impaired transport and associated with neuronal C3 production. C3d+ microglial clusters were not specific to MS as they were also found in stroke and experimental TBI. We conclude that C3d+ microglial clusters in MS are not part of an acute attack against myelinated axons. As such it is unlikely that they drive formation of new lesions but could represent a physiological mechanism to remove irreversibly damaged axons in chronic disease. GLIA 2017;65:264-277.
[Mh] Termos MeSH primário: Complemento C3/metabolismo
Microglia/metabolismo
Esclerose Múltipla/patologia
[Mh] Termos MeSH secundário: Doença Aguda
Adulto
Idoso
Idoso de 80 Anos ou mais
Animais
Autopsia
Doença Crônica
Complemento C3/genética
Citocinas/metabolismo
Proteínas de Ligação a DNA/metabolismo
Modelos Animais de Doenças
Feminino
Traumatismos Cranianos Fechados/patologia
Seres Humanos
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Meia-Idade
Proteínas da Mielina/metabolismo
Proteínas do Tecido Nervoso/metabolismo
Neurônios/patologia
Acidente Vascular Cerebral/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (AIF1 protein, human); 0 (C3 protein, human); 0 (Complement C3); 0 (Cytokines); 0 (DNA-Binding Proteins); 0 (Myelin Proteins); 0 (Nerve Tissue Proteins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1002/glia.23090


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[PMID]:29180170
[Au] Autor:Carlin MN; Daneshpajouh A; Catino J; Bukur M
[Ad] Endereço:Department of Trauma & Critical Care, Delray Medical Center, Nova Southeastern University, Delray Beach, Florida; Department of General Surgery, Larkin Community Hospital, Nova Southeastern University, South Miami, Florida. Electronic address: margoca@pcom.edu.
[Ti] Título:Money well spent? A cost and utilization analysis of prophylactic inferior vena cava filter placement in high-risk trauma patients.
[So] Source:J Surg Res;220:105-111, 2017 Dec.
[Is] ISSN:1095-8673
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Inferior vena cava filters (IVCF) for venous thromboembolic prophylaxis in high-risk trauma patients is a controversial practice. Utilization of IVCF prophylaxis was evaluated at a level 1 trauma center. Daily cost of IVCF prophylaxis, time to IVCF, duration between IVCF and chemoprophylaxis, and number of patients needed to treat (NNT) to prevent pulmonary embolism (PE) was calculated. METHODS: A retrospective review of prophylactic IVCF over a 5-year period (2010-2014). Demographic, physiologic, injury, procedural, and outcome data were abstracted from the administrative trauma database. Medicare fees and days without chemoprophylaxis were used to determine daily IVCF cost. NNT was calculated using PE events in a cohort without IVCF. RESULTS: Over the 5-year period, 146 patients with mean age 56.3 y (SD ± 24.2), 67.8% male, underwent prophylactic IVCF. Predominant mechanisms of injuries were falls (45.9%) and motor vehicle accidents (20.5%) with median Injury Severity Score of 25 (intraquartile range [IQR] 16-29) and head Abbreviated Injury Score of 3 (IQR 3-5). Most common operative interventions required in 24.7% were orthopedic (25.3%) and neurosurgical (21.9%). Median time to IVCF was 78 h (IQR 48-144). Most common IVCF indications were closed head injury (48.6%) and spinal injuries (30.8%). Median time to administration of chemoprophylaxis was 96 h after IVCF (IQR 24-192) in 57.5%. Median IVCF cost was $759/d (IQR $361-$1897) compared with $4.32 for chemoprophylaxis. PE occurred in 0.26% without IVCF. PE did not occur with prophylactic IVCF. Estimated NNT was 379 (95% CI 265, 661). CONCLUSIONS: Prophylactic IVCF placement is a costly practice with relatively low benefit. Anticipated time without chemoprophylaxis and patient criteria should be considered before routine IVCF placement.
[Mh] Termos MeSH primário: Custos e Análise de Custo
Embolia Pulmonar/prevenção & controle
Filtros de Veia Cava/economia
Filtros de Veia Cava/utilização
Veia Cava Inferior/cirurgia
[Mh] Termos MeSH secundário: Acidentes por Quedas/economia
Acidentes de Trânsito/economia
Adulto
Idoso
Idoso de 80 Anos ou mais
Anticoagulantes/uso terapêutico
Feminino
Traumatismos Cranianos Fechados/cirurgia
Seres Humanos
Escala de Gravidade do Ferimento
Masculino
Medicare
Meia-Idade
Estudos Retrospectivos
Fatores de Risco
Traumatismos da Coluna Vertebral/cirurgia
Fatores de Tempo
Centros de Traumatologia/economia
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticoagulants)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE


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[PMID]:27775478
[Au] Autor:Bahrami N; Sharma D; Rosenthal S; Davenport EM; Urban JE; Wagner B; Jung Y; Vaughan CG; Gioia GA; Stitzel JD; Whitlow CT; Maldjian JA
[Ad] Endereço:From the Advanced Neuroscience Imaging Research (ANSIR) Laboratory (N.B., D.S., E.M.D., Y.J., C.T.W., J.A.M.), Wake Forest School of Medicine (S.R.), Department of Radiology-Neuroradiology (Y.J., C.T.W.), Department of Biomedical Engineering (N.B., J.E.U., Y.J., J.D.S., C.T.W.), Department of Family
[Ti] Título:Subconcussive Head Impact Exposure and White Matter Tract Changes over a Single Season of Youth Football.
[So] Source:Radiology;281(3):919-926, 2016 Dec.
[Is] ISSN:1527-1315
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose To examine the effects of subconcussive impacts resulting from a single season of youth (age range, 8-13 years) football on changes in specific white matter (WM) tracts as detected with diffusion-tensor imaging in the absence of clinically diagnosed concussions. Materials and Methods Head impact data were recorded by using the Head Impact Telemetry system and quantified as the combined-probability risk-weighted cumulative exposure (RWE ). Twenty-five male participants were evaluated for seasonal fractional anisotropy (FA) changes in specific WM tracts: the inferior fronto-occipital fasciculus (IFOF), inferior longitudinal fasciculus, and superior longitudinal fasciculus (SLF). Fiber tracts were segmented into a central core and two fiber terminals. The relationship between seasonal FA change in the whole fiber, central core, and the fiber terminals with RWE was also investigated. Linear regression analysis was conducted to determine the association between RWE and change in fiber tract FA during the season. Results There were statistically significant linear relationships between RWE and decreased FA in the whole (R = 0.433; P = .003), core (R = 0.3649; P = .007), and terminals (R = 0.5666; P < .001) of left IFOF. A trend toward statistical significance (P = .08) in right SLF was observed. A statistically significant correlation between decrease in FA of the right SLF terminal and RWE was also observed (R = 0.2893; P = .028). Conclusion This study found a statistically significant relationship between head impact exposure and change of FA fractional anisotropy value of whole, core, and terminals of left IFOF and right SLF's terminals where WM and gray matter intersect, in the absence of a clinically diagnosed concussion. RSNA, 2016.
[Mh] Termos MeSH primário: Concussão Encefálica/patologia
Futebol Americano/lesões
Traumatismos Cranianos Fechados/patologia
Substância Branca/patologia
[Mh] Termos MeSH secundário: Adolescente
Criança
Imagem de Tensor de Difusão
Lobo Frontal/patologia
Seres Humanos
Masculino
Fibras Nervosas Mielinizadas/patologia
Vias Neurais/patologia
Lobo Occipital/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171201
[Lr] Data última revisão:
171201
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29132572
[Au] Autor:Long B; Koyfman A
[Ad] Endereço:Department of Emergency Medicine, San Antonio Military Medical Center, 3841 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA. Electronic address: Brit.long@yahoo.com.
[Ti] Título:Secondary Gains: Advances in Neurotrauma Management.
[So] Source:Emerg Med Clin North Am;36(1):107-133, 2018 Feb.
[Is] ISSN:1558-0539
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neurotrauma is a leading cause of death and is associated with many secondary injuries. A balance of mean arterial pressure (MAP) and intracranial pressure (ICP) is required to ensure adequate cerebral blood flow and cerebral perfusion pressure. Evaluation and management in the emergency department entails initial stabilization and resuscitation while assessing neurologic status. ICP management follows a tiered approach. Intubation requires consideration of preoxygenation, head of bed elevation, first pass success, and adequate analgesia and sedation. Early consultation with neurosurgery is needed for definitive therapy. Focused evaluation and management play a significant role in optimizing patient outcomes.
[Mh] Termos MeSH primário: Lesões Encefálicas Traumáticas/terapia
Traumatismos da Medula Espinal/terapia
[Mh] Termos MeSH secundário: Lesões Encefálicas Traumáticas/diagnóstico
Traumatismos Cranianos Fechados/diagnóstico
Traumatismos Cranianos Fechados/terapia
Seres Humanos
Traumatismos da Medula Espinal/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171115
[St] Status:MEDLINE


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[PMID]:28791677
[Au] Autor:Krakowka K
[Ad] Endereço:School of Archaeology, University of Oxford, Oxford, OX1 3QY, United Kingdom.
[Ti] Título:Patterns and prevalence of violence-related skull trauma in medieval London.
[So] Source:Am J Phys Anthropol;164(3):488-504, 2017 Nov.
[Is] ISSN:1096-8644
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: This study aims to identify the patterns and prevalence of violence-related skull trauma (including the cranium and mandible) among a large sample of skeletons from medieval London (1050-1550 AD). MATERIALS AND METHODS: In total, data from 399 skulls, representing six different sites from across medieval London, were analyzed for evidence of trauma and assessed for the likelihood that it was caused by violence. The sites include the three parish cemeteries of St Nicholas Shambles (GPO75), St Lawrence Jewry (GYE92), and St Benet Sherehog (ONE94); the two monastic houses of London Blackfriars (PIC87) and St Mary Graces (MIN86); and the early inmate cemetery from the medieval hospital of St Mary Spital (NRT85). RESULTS: The overall findings suggest that violence affected all aspects of medieval London society, but how that violence was characterized largely depended on sex and burial location. Specifically, males from the lay cemeteries appear to have been the demographic most affected by violence-related skull injuries, particularly blunt force trauma to the cranial vault. DISCUSSION: Using both archaeological and historical evidence, the results suggest that violence in medieval London may have been more prevalent than in other parts of medieval England, particularly rural environments, but similar to other parts of medieval Europe. However, more studies focusing on medieval trauma, and violence specifically, need to be carried out to further strengthen these results. In particular, males from the lay cemeteries were disproportionately affected by violence-related trauma, especially blunt force trauma. It perhaps indicates a means of informal conflict resolution as those of lower status did not always have the newly established medieval legal system available to them.
[Mh] Termos MeSH primário: Traumatismos Cranianos Fechados/epidemiologia
Traumatismos Cranianos Fechados/história
Crânio/lesões
Crânio/patologia
Violência/história
[Mh] Termos MeSH secundário: Adolescente
Adulto
Determinação da Idade pelo Esqueleto
Criança
Pré-Escolar
Feminino
História Medieval
Seres Humanos
Lactente
Londres
Masculino
Meia-Idade
Prevalência
Adulto Jovem
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE
[do] DOI:10.1002/ajpa.23288


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[PMID]:28700585
[Au] Autor:Mower WR; Gupta M; Rodriguez R; Hendey GW
[Ad] Endereço:UCLA Department of Emergency Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, California, United States of America.
[Ti] Título:Validation of the sensitivity of the National Emergency X-Radiography Utilization Study (NEXUS) Head computed tomographic (CT) decision instrument for selective imaging of blunt head injury patients: An observational study.
[So] Source:PLoS Med;14(7):e1002313, 2017 Jul.
[Is] ISSN:1549-1676
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Clinicians, afraid of missing intracranial injuries, liberally obtain computed tomographic (CT) head imaging in blunt trauma patients. Prior work suggests that clinical criteria (National Emergency X-Radiography Utilization Study [NEXUS] Head CT decision instrument [DI]) can reliably identify patients with important injuries, while excluding injury, and the need for imaging in many patients. Validating this DI requires confirmation of the hypothesis that the lower 95% confidence limit for its sensitivity in detecting serious injury exceeds 99.0%. A secondary goal of the study was to complete an independent validation and comparison of the Canadian and NEXUS Head CT rules among the subgroup of patients meeting the inclusion and exclusion criteria. METHODS AND FINDINGS: We conducted a prospective observational study of the NEXUS Head CT DI in 4 hospital emergency departments between April 2006 and December 2015. Implementation of the rule requires that patients satisfy 8 criteria to achieve "low-risk" classification. Patients are excluded from "low-risk" classification and assigned "high-risk" status if they fail to meet 1 or more criteria. We examined the instrument's performance in assigning "high-risk" status to patients requiring neurosurgical intervention among a cohort of 11,770 blunt head injury patients. The NEXUS Head CT DI assigned high-risk status to 420 of 420 patients requiring neurosurgical intervention (sensitivity, 100.0% [95% confidence interval [CI]: 99.1%-100.0%]). The instrument assigned low-risk status to 2,823 of 11,350 patients who did not require neurosurgical intervention (specificity, 24.9% [95% CI: 24.1%-25.7%]). None of the 2,823 low-risk patients required neurosurgical intervention (negative predictive value [NPV], 100.0% [95% CI: 99.9%-100.0%]). The DI assigned high-risk status to 759 of 767 patients with significant intracranial injuries (sensitivity, 99.0% [95% CI: 98.0%-99.6%]). The instrument assigned low-risk status to 2,815 of 11,003 patients who did not have significant injuries (specificity, 25.6% [95% CI: 24.8%-26.4%]). Significant injuries were absent in 2,815 of the 2,823 patients assigned low-risk status (NPV, 99.7% [95% CI: 99.4%-99.9%]). Of our patients, 7,759 (65.9%) met the inclusion and exclusion criteria of the Canadian Head CT rule, including 111 patients (1.43%) who required neurosurgical intervention and 306 (3.94%) who had significant intracranial injuries. In our study, the Canadian criteria for neurosurgical intervention identified 108 of 111 patients requiring neurosurgical intervention to yield a sensitivity of 97.3% (95% CI: 92.3%-99.4%) and exhibited a specificity of 58.8% (95% CI: 57.7%-59.9%). The NEXUS rule, when applied to this same cohort, identified all 111 patients requiring neurosurgical intervention, yielding a sensitivity of 100% (95% CI: 96.7%-100.0%) with a specificity of 32.6% (95% CI: 31.5%-33.6%). Our study found that the Canadian medium-risk factors identified 301 of 306 patients with significant injuries (sensitivity = 98.4%; 95% CI: 96.2%-99.5%), while the NEXUS rule identified 299 of these patients (sensitivity = 97.7%; 95% CI: 95.3%-99.1%). In our study, the Canadian medium-risk rule exhibited a specificity of 12.3% (95% CI: 11.6%-13.1%), while the NEXUS rule exhibited a specificity of 33.3% (95% CI: 32.3%-34.4%). Limitations of the study may arise from application of the rule by different clinicians in different environments. Clinicians may vary in their interpretation and application of the instrument's criteria and risk assignment and may also vary in deciding which patients require intervention. The instrument's specificity is also subject to spectrum bias and may change with variations in the proportion of "low-risk" patients seen in other centers. CONCLUSIONS: The NEXUS Head CT DI reliably identifies blunt trauma patients who require head CT imaging and could significantly reduce the use of CT imaging.
[Mh] Termos MeSH primário: Técnicas de Apoio para a Decisão
Traumatismos Cranianos Fechados/diagnóstico por imagem
Tomografia Computadorizada por Raios X/normas
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
California
Criança
Pré-Escolar
Feminino
Traumatismos Cranianos Fechados/etiologia
Seres Humanos
Lactente
Recém-Nascido
Masculino
Meia-Idade
Estudos Prospectivos
Tomografia Computadorizada por Raios X/instrumentação
Ferimentos não Penetrantes/diagnóstico por imagem
Ferimentos não Penetrantes/etiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY; VALIDATION STUDIES
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pmed.1002313


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[PMID]:28655000
[Au] Autor:Cusimano MD; Casey J; Jing R; Mishra A; Solarski M; Techar K; Zhang S
[Ad] Endereço:Department of Neurosurgery, St Michael's Hospital, Toronto, Ontario, Canada.
[Ti] Título:Assessment of Head Collision Events During the 2014 FIFA World Cup Tournament.
[So] Source:JAMA;317(24):2548-2549, 2017 06 27.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Concussão Encefálica/etiologia
Traumatismos Cranianos Fechados/epidemiologia
Futebol/lesões
[Mh] Termos MeSH secundário: Aniversários e Eventos Especiais
Consenso
Traumatismos Cranianos Fechados/complicações
Traumatismos Cranianos Fechados/diagnóstico
Seres Humanos
Incidência
Volta ao Esporte/estatística & dados numéricos
Gravação em Vídeo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.6204


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[PMID]:28630361
[Au] Autor:Joswig H; Ng WP
[Ad] Endereço:London Health Sciences Centre, Clinical Neurological Sciences, Division of Neurosurgery, University Hospital, London Ont. holger.joswig@gmail.com.
[Ti] Título:Traumatic pseudoaneurysm of the superficial temporal artery.
[So] Source:CMAJ;189(24):E837, 2017 06 19.
[Is] ISSN:1488-2329
[Cp] País de publicação:Canada
[La] Idioma:eng
[Mh] Termos MeSH primário: Falso Aneurisma/etiologia
Falso Aneurisma/cirurgia
Traumatismos Cranianos Fechados/cirurgia
Aneurisma Intracraniano/cirurgia
Artérias Temporais/lesões
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Artérias Temporais/cirurgia
Procedimentos Cirúrgicos Vasculares
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE
[do] DOI:10.1503/cmaj.161364


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[PMID]:28437717
[Au] Autor:Davceva N; Sivevski A; Basheska N
[Ad] Endereço:Institute of Forensic Medicine, Criminology and Medical Deontology, "Mother Theresa" No 19, 1000 Skopje, Republic of Macedonia. Electronic address: drdavcevamk@yahoo.com.
[Ti] Título:Traumatic axonal injury, a clinical-pathological correlation.
[So] Source:J Forensic Leg Med;48:35-40, 2017 May.
[Is] ISSN:1878-7487
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Traumatic axonal injury (TAI) is a distinct clinicopathological entity that can cause serious impairment of the brain function and can sometimes be found as a concrete cause of death. It has been discussed from the perspective of its biomechanical importance, and also from the standpoint of certain criteria for the pathological diagnosis of TAI. However, since the time when DAI (diffuse axonal injury) was initially described, there have been few, if any, discussions about the clinical-pathological correlation in TAI. This paper is an attempt to address this issue. For the purpose of certain pathological diagnoses of TAI, 63 cases with closed head injuries have been subjected to the complete forensic-neuropathological examination, involving immunohistochemistry with antibody against ß-APP. In the diagnosis of TAI strict criteria have been followed. Then, retrograde analysis of the clinical parameters has been performed in order to determine some clinical-pathological correlation. The following two most reliable parameters of the impairment of the brain function have been analyzed: the impairment of the consciousness and the time of survival. Comparing the two groups, the one with TAI and the other without TAI, and using appropriate statistical evaluation, our results show that TAI is not a significant contributing factor to the lethal outcome in the early post injury period (24 h), but it is undoubtedly a contributing factor for the severe impairment of the brain function indicated through the status of the consciousness.
[Mh] Termos MeSH primário: Precursor de Proteína beta-Amiloide/metabolismo
Lesão Axonal Difusa/patologia
Traumatismos Cranianos Fechados/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Axônios/metabolismo
Axônios/patologia
Concussão Encefálica/metabolismo
Criança
Pré-Escolar
Coma/metabolismo
Feminino
Seres Humanos
Imuno-Histoquímica
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amyloid beta-Protein Precursor)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE


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[PMID]:28403661
[Au] Autor:Naiyer N; Chounthirath T; Smith GA
[Ad] Endereço:1 Center for Injury Research and Policy, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
[Ti] Título:Pediatric Cheerleading Injuries Treated in Emergency Departments in the United States.
[So] Source:Clin Pediatr (Phila);56(11):985-992, 2017 Oct.
[Is] ISSN:1938-2707
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study investigates the epidemiology of cheerleading injuries to children in the United States. Data were analyzed from the National Electronic Injury Surveillance System for children 5 through 18 years of age treated in US emergency departments for cheerleading injuries from 1990 through 2012. An estimated 497 095 children ages 5 to 18 years were treated in US emergency departments for a cheerleading injury during the 23-year study period, averaging 21 613 injured children per year. From 1990 to 2012, the annual cheerleading injury rate increased significantly by 189.1%; and from 2001 to 2012, the annual rate of cheerleading-related concussion/closed head injury increased significantly by 290.9%. Falls were the most common mechanism of injury (29.4%) and were more likely to lead to hospitalization (relative risk = 2.47; 95% confidence interval = 1.67-3.68) compared with other injury mechanisms. The rising number and rate of pediatric cheerleading injuries underscore the need for increased efforts to prevent these injuries.
[Mh] Termos MeSH primário: Traumatismos em Atletas/epidemiologia
Serviço Hospitalar de Emergência
Hospitalização/estatística & dados numéricos
[Mh] Termos MeSH secundário: Acidentes por Quedas/estatística & dados numéricos
Adolescente
Distribuição por Idade
Traumatismos em Atletas/terapia
Concussão Encefálica/epidemiologia
Criança
Pré-Escolar
Feminino
Traumatismos Cranianos Fechados/epidemiologia
Seres Humanos
Masculino
Risco
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE
[do] DOI:10.1177/0009922817702938



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