| [PMID]: | 29211700 |
| [Au] Autor: | Kim MJ; Kim JH; Jeon HS; Wee WR; Hyon JY |
| [Ad] Endereço: | *Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea; and†Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam, Korea. |
| [Ti] Título: | Effect of Histocompatibility Y Antigen Matching on Graft Survival in Primary Penetrating Keratoplasty. |
| [So] Source: | Cornea;37(1):33-38, 2018 Jan. |
| [Is] ISSN: | 1536-4798 |
| [Cp] País de publicação: | United States |
| [La] Idioma: | eng |
| [Ab] Resumo: | PURPOSE: To investigate the influence of histocompatibility Y (H-Y) antigen matching on corneal graft survival in primary penetrating keratoplasty (PK). METHODS: Medical records of patients who underwent primary PK at Seoul National University Bundang Hospital between June 2005 and October 2015 were retrospectively analyzed. The eyes were classified into 2 groups: H-Y-compatible (115 eyes) and H-Y-incompatible (23 eyes). The H-Y-compatible group included donor/recipient combinations of male/male (57 eyes), female/male (44 eyes), and female/female (14 eyes). The H-Y-incompatible group included the male/female (23 eyes) combination alone. A subgroup analysis of low- and high-risk patients according to preoperative diagnoses was also performed. Survival analysis was conducted using the Kaplan-Meier method; differences between groups were assessed with a log-rank test. RESULTS: A total of 138 eyes from 136 patients (age: 58 ± 18 years) were enrolled. Rejection-free graft survival and graft survival were not significantly different between H-Y-compatible and H-Y-incompatible groups (χ = 0.4, P = 0.548; χ = 1.9; P = 0.17, respectively). Preoperative diagnoses of high-risk cases included those with corneal perforation or thinning (8.7%) and infectious keratitis (7.2%). Low-risk cases included corneal opacity (50.0%), bullous keratopathy (25.4%), keratoconus (5.8%), and corneal dystrophy (2.9%). In the high-risk group, rejection-free graft survival rate was significantly higher in the H-Y-compatible group (χ = 3.9, P = 0.049). CONCLUSIONS: H-Y antigen matching does not influence graft rejection and failure in cases of primary PK. However, matching the H-Y antigen could help reduce graft rejection, especially in preoperatively high-risk patients. |
| [Mh] Termos MeSH primário: |
Doenças da Córnea/cirurgia
Sobrevivência de Enxerto/imunologia
Antígeno H-Y/imunologia
Ceratoplastia Penetrante
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| [Mh] Termos MeSH secundário: |
Idoso
Aloenxertos
Feminino
Rejeição de Enxerto/diagnóstico
Teste de Histocompatibilidade
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
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| [Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (H-Y Antigen) |
| [Em] Mês de entrada: | 1803 |
| [Cu] Atualização por classe: | 180309 |
[Lr] Data última revisão:
| 180309 |
| [Sb] Subgrupo de revista: | IM |
| [Da] Data de entrada para processamento: | 171207 |
| [St] Status: | MEDLINE |
| [do] DOI: | 10.1097/ICO.0000000000001394 |
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