Base de dados : MEDLINE
Pesquisa : C11.204.299 [Categoria DeCS]
Referências encontradas : 3381 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 339 ir para página                         

  1 / 3381 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29390260
[Au] Autor:Chiang HH; Wieland RS; Rogers TS; Gibson PC; Atweh G; McCormick G
[Ad] Endereço:University of Vermont College of Medicine.
[Ti] Título:Paraproteinemic keratopathy in monoclonal gammopathy of undetermined significance treated with primary keratoprosthesis: Case report, histopathologic findings, and world literature review.
[So] Source:Medicine (Baltimore);96(50):e8649, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: We report a case of paraproteinemic keratopathy associated with monoclonal gammopathy of undetermined significance, treated with keratoprosthesis as a primary penetrating procedure. Histopathological findings and a world literature review are presented. PATIENT CONCERNS: A 74 year old female recently diagnosed with monoclonal gammopathy undetermined significance presented with progressive blurry vision bilaterally. DIAGNOSES: Examination revealed corneal opacities consistent with paraproteinemic keratopathy. INTERVENTIONS: Corneal transplantation with the Boston Type I keratoprosthesis was performed on the right and, a year later, on the left. OUTCOMES: Visual outcomes were good. Histopathological staining of host corneal buttons were consistent with monoclonality, and electron microscopy revealed fibrillar extracellular aggregates within intervening normal stroma. LESSONS: Corneal deposits may be the only manifestation of monoclonal gammopathy of undetermined significance in patients who are otherwise systemically asymptomatic. Ophthalmologists who encounter corneal opacities may order the appropriate diagnostic studies to determine the presence of occult systemic disease. Risk of graft failure after penetrating keratoplasty from recurring opacities is high, so keratoprosthesis as a primary penetrating procedure may afford superior long-term outcomes. Host corneal buttons retrieved from penetrating keratoplasty or corneal biopsy may be sent for histopathological examination to confirm the diagnosis.
[Mh] Termos MeSH primário: Doenças da Córnea/etiologia
Opacidade da Córnea/etiologia
Gamopatia Monoclonal de Significância Indeterminada/complicações
Paraproteinemias/complicações
[Mh] Termos MeSH secundário: Idoso
Doenças da Córnea/cirurgia
Opacidade da Córnea/cirurgia
Transplante de Córnea
Feminino
Seres Humanos
Transtornos da Visão/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008649


  2 / 3381 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29227512
[Au] Autor:Anumanthan G; Sharma A; Waggoner M; Hamm CW; Gupta S; Hesemann NP; Mohan RR
[Ti] Título:Efficacy and Safety Comparison Between Suberoylanilide Hydroxamic Acid and Mitomycin C in Reducing the Risk of Corneal Haze After PRK Treatment In Vivo.
[So] Source:J Refract Surg;33(12):834-839, 2017 Dec 01.
[Is] ISSN:1081-597X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: This study compared the efficacy and safety of suberoylanilide hydroxamic acid (SAHA) and mitomycin C (MMC) up to 4 months in the prevention of corneal haze induced by photorefractive keratectomy (PRK) in rabbits in vivo. METHODS: Corneal haze in rabbits was produced with -9.00 diopter PRK. A single application of SAHA (25 µM) or MMC (0.02%) was applied topically immediately after PRK. Effects of the two drugs were analyzed by slit-lamp microscope, specular microscope, TUNEL assay, and immunofluorescence. RESULTS: Single topical adjunct use of SAHA (25 µM) or MMC (0.02%) after PRK attenuated more than 95% corneal haze and myofibroblast formation (P < .001). SAHA did not reduce keratocyte density, cause keratocyte apoptosis, or increase immune cell infiltration compared to MMC (P < .01 or .001). Furthermore, SAHA dosing did not compromise corneal endothelial phenotype, density, or function in rabbit eyes, whereas MMC application did (P < .01 or .001). CONCLUSIONS: SAHA and MMC significantly decreased corneal haze after PRK in rabbits in vivo. SAHA exhibited significantly reduced short- and long-term damage to the corneal endothelium compared to MMC in rabbits. SAHA is an effective and potentially safer alternative to MMC for the prevention of corneal haze after PRK. Clinical trials are warranted. [J Refract Surg. 2017;33(12):834-839.].
[Mh] Termos MeSH primário: Alquilantes/uso terapêutico
Opacidade da Córnea/prevenção & controle
Modelos Animais de Doenças
Inibidores de Histona Desacetilases/uso terapêutico
Ácidos Hidroxâmicos/uso terapêutico
Mitomicina/uso terapêutico
Ceratectomia Fotorrefrativa/efeitos adversos
[Mh] Termos MeSH secundário: Alquilantes/efeitos adversos
Animais
Apoptose
Córnea/cirurgia
Opacidade da Córnea/etiologia
Técnica Indireta de Fluorescência para Anticorpo
Inibidores de Histona Desacetilases/efeitos adversos
Ácidos Hidroxâmicos/efeitos adversos
Marcação In Situ das Extremidades Cortadas
Mitomicina/efeitos adversos
Coelhos
Lâmpada de Fenda
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkylating Agents); 0 (Histone Deacetylase Inhibitors); 0 (Hydroxamic Acids); 50SG953SK6 (Mitomycin); 58IFB293JI (vorinostat)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.3928/1081597X-20170921-02


  3 / 3381 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27777504
[Au] Autor:Lapp T; Hildebrand A; Böhringer D; Betancor PK; Schlunck G; Reinhard T
[Ad] Endereço:Eye Center Medical Center, Faculty of Medicine, University of Freiburg, Germany.
[Ti] Título:Optimizing rejection readouts in a corneal allograft transplantation model.
[So] Source:Mol Vis;22:1248-1255, 2016.
[Is] ISSN:1090-0535
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To evaluate the feasibility of anterior segment spectral domain optic coherence tomography (ASOCT) as rejection readout in a keratoplasty mouse model and to compare ASOCT against the current standard (i.e., a clinical score system). Furthermore, to compare both approaches with respect to intra- and inter-individual observer variability and to calculate a critical point that distinguishes between rejection and non-rejection in ASOCT analysis. METHODS: Allogeneic penetrating keratoplasties (PKs) were performed using C3H/He donor mice and BALB/c recipient mice; syngeneic transplantations served as controls using BALB/c donors and recipients. Corneal graft rejection was determined with a clinical score. ASOCT was used to determine the central thickness of the corneal grafts in the same animals. The rejection status was corroborated with histopathological examination. RESULTS: The median survival time (MST) of the corneal allografts in the wild-type BALB/c mice was 12 days. Allogeneic transplantation led to a 100% rejection rate, whereas signs of rejection after syngeneic transplantation appeared in up to 20% of the mice. Central corneal thickness (CCT) determination via customized software revealed a direct correlation with the clinical score. Receiver operating curve (ROC) analysis confirmed CCT as a valid surrogate for rejection. Calculation of the area under the curve (AUC) revealed a value of 0.88 with an optimal cut-off at 267 pixels. CONCLUSIONS: An increase in the CCT during acute allogeneic corneal graft rejection significantly correlated with the clinical surrogate parameter "corneal opacity." ASOCT not only generates source data, but also analysis of the ASOCT data shows lower readout variability and fewer interpreter variations than the clinical score commonly used to define the time point of graft rejection in mice.
[Mh] Termos MeSH primário: Segmento Anterior do Olho/patologia
Modelos Animais de Doenças
Rejeição de Enxerto/diagnóstico
Ceratoplastia Penetrante
Tomografia de Coerência Óptica
[Mh] Termos MeSH secundário: Animais
Área Sob a Curva
Opacidade da Córnea/patologia
Paquimetria Corneana
Feminino
Rejeição de Enxerto/classificação
Sobrevivência de Enxerto/fisiologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos C3H
Variações Dependentes do Observador
Curva ROC
Fatores de Tempo
Transplante Homólogo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


  4 / 3381 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28465303
[Au] Autor:Solebo AL; Teoh L; Rahi J
[Ad] Endereço:Lifecourse Epidemiology and Biostatistics Section, Population, Policy and Practice Programme, Institute of Child Health, University College London, London, UK.
[Ti] Título:Epidemiology of blindness in children.
[So] Source:Arch Dis Child;102(9):853-857, 2017 09.
[Is] ISSN:1468-2044
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An estimated 14 million of the world's children are blind. A blind child is more likely to live in socioeconomic deprivation, to be more frequently hospitalised during childhood and to die in childhood than a child not living with blindness. This update of a previous review on childhood visual impairment focuses on emerging therapies for children with severe visual disability (severe visual impairment and blindness or SVI/BL).For children in higher income countries, cerebral visual impairment and optic nerve anomalies remain the most common causes of SVI/BL, while retinopathy of prematurity (ROP) and cataract are now the most common avoidable causes. The constellation of causes of childhood blindness in lower income settings is shifting from infective and nutritional corneal opacities and congenital anomalies to more resemble the patterns seen in higher income settings. Improvements in maternal and neonatal health and investment in and maintenance of national ophthalmic care infrastructure are the key to reducing the burden of avoidable blindness. New therapeutic targets are emerging for childhood visual disorders, although the safety and efficacy of novel therapies for diseases such as ROP or retinal dystrophies are not yet clear. Population-based epidemiological research, particularly on cerebral visual impairment and optic nerve hypoplasia, is needed in order to improve understanding of risk factors and to inform and support the development of novel therapies for disorders currently considered 'untreatable'.
[Mh] Termos MeSH primário: Cegueira/epidemiologia
[Mh] Termos MeSH secundário: Cegueira/diagnóstico
Cegueira/etiologia
Catarata/complicações
Catarata/epidemiologia
Criança
Opacidade da Córnea/complicações
Opacidade da Córnea/epidemiologia
Oftalmopatias Hereditárias/complicações
Oftalmopatias Hereditárias/epidemiologia
Saúde Global/estatística & dados numéricos
Seres Humanos
Renda/estatística & dados numéricos
Recém-Nascido
Nervo Óptico/anormalidades
Prevalência
Doenças Retinianas/complicações
Doenças Retinianas/epidemiologia
Retinopatia da Prematuridade/complicações
Retinopatia da Prematuridade/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180124
[Lr] Data última revisão:
180124
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1136/archdischild-2016-310532


  5 / 3381 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28662686
[Au] Autor:Chang RQ; Du Y; Zhu XJ; Lu Y
[Ad] Endereço:Department of Ophthalmology, Eye and Ear, Nose, and Throat Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
[Ti] Título:Type II Peter's anomaly with histopathological proof: a case report.
[So] Source:BMC Ophthalmol;17(1):110, 2017 Jun 29.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Peter's anomaly is a rare congenital anterior segment dysgenesis with poor visual results. This case report describes a case of bilateral Type II Peter's anomaly with notable clinical and histopathological features. CASE PRESENTATION: A 7-year-old boy was admitted to our center with complaints of bilateral central opacification, photophobia and severe reduced vision since birth. He underwent phacoemulsification, intraocular lens (IOL) implantation and anterior vitrectomy on the right eye in another medical institution two years ago. Slit lamp examination revealed bilateral central corneal opacity, few strands of peripheral iris, irregular pupils and cloudy lens with central adhesion to posterior corneal surface in the left eye. Additionally, a history of premature birth and mental retardation was also noted. The patient was diagnosed with Peter's anomaly in the left eye, pseudophakia in the right eye and bilateral amblyopia. Similar surgery to the right one was performed on the left eye. A vesicle-like structure was found in the anterior chamber intraoperatively, which was composed mainly of immature lens and some corneal stroma as revealed by postoperative histopathological examinations. CONCLUSIONS: The exact mechanism of Peter's anomaly is not completely understood, however, the notable histopathological features of tissue obtained from the present case may provide evidence to the hypothesis of developmental anomalies.
[Mh] Termos MeSH primário: Segmento Anterior do Olho/anormalidades
Córnea/patologia
Opacidade da Córnea/diagnóstico
Anormalidades do Olho/diagnóstico
Esclera/patologia
[Mh] Termos MeSH secundário: Criança
Diagnóstico Diferencial
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-017-0502-7


  6 / 3381 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28606270
[Au] Autor:Cai SB; Sun M; Li S; Xu LJ; Wang W; Wang J; Hu WK; Li XY; Wang P; Zhang H; Li GG
[Ad] Endereço:Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
[Ti] Título:[Keratoplasty classification and primary disease spectrum analysis of 315 cases].
[So] Source:Zhonghua Yan Ke Za Zhi;53(6):460-463, 2017 Jun 11.
[Is] ISSN:0412-4081
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To identify the primary disease spectrum and trends of surgical procedure of keratoplasty patients. Retrospective case series study. To review all patients who underwent keratoplasty at Department of ophthalmology in Tongji Hospital from January 1, 2012 to December 31, 2015. The data collected included age, sex, birthplace, and primary corneal disease and associated surgical procedures. Then the data were compared with similar papers domestic and foreign. A total of 315 keratoplasties were performed during this 4-year period. The average age of patients at time of surgery was (42.0± 1.8) years, range from 33 days to 89 years, 229 cases (72.7%) were from 18 to 65 years; male: female ratio was 2.06:1. Totally 289 cases (91.8%)came from Hubei province, 26 cases (8.2%) were from other provinces. The leading indications for corneal transplantation were keratitis in 125 cases (39.7%), followed by corneal scar in 71 cases (22.5%), keratoconus in 41 cases (13.0%), pseudophakic bullous keratopathy in 26 cases (8.3%), corneal dermoid in 18 cases (5.7%), corneal dystrophy and degeneration in 16 cases (5.1%), and others (including chemical injuries, thermal burns, post-traumatic corneal scar and corneal opacity) in 18 cases (5.7%). Of the 125 keratitis cases, 51 cases (40.8%) were associated with fungus, 43 cases (34.4%)were associated with virus, and 24 cases (19.2%)were associated with bacterial. In accordance with the classification of corneal transplant surgery, penetrating keratoplasty was performed in 212 cases (67.3% ), lamellar keratoplasty was completed in 87 cases (27.6% ), corneal endothelial transplantation was made in 16 patients (5.1%). Infectious keratitis was the leading indication for corneal transplantation followed by corneal scar, keratoconus and pseudophakic bullous keratopathy in Tongji hospital patients who underwent keratoplasty. And fungus was the first cause of infectious keratitis. Penetrating keratoplasty was still the main part of corneal transplantation. .
[Mh] Termos MeSH primário: Doenças da Córnea/cirurgia
Transplante de Córnea
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Distrofias Hereditárias da Córnea/cirurgia
Opacidade da Córnea/cirurgia
Cisto Dermoide/cirurgia
Feminino
Seres Humanos
Internacionalidade
Ceratite/cirurgia
Ceratocone/cirurgia
Ceratoplastia Penetrante
Masculino
Meia-Idade
Estudos Retrospectivos
Análise Espectral
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170614
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0412-4081.2017.06.013


  7 / 3381 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28545414
[Au] Autor:Zhang S; Xu H; Zheng K; Zhao J; Jian W; Li M; Zhou X
[Ad] Endereço:Department of ophthalmology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.
[Ti] Título:The observation during small incision lenticule extraction for myopia with corneal opacity.
[So] Source:BMC Ophthalmol;17(1):80, 2017 May 25.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To evaluate the feasibility and efficacy of small incision lenticule extraction (SMILE) in the treatment of myopia with corneal opacity. METHODS: To evaluate the treatment of myopia with corneal opacity, 9 patients (4 males, 5 females) who underwent SMILE were enrolled in this prospective clinical study. One eye of each patient was treated. The results of laser scanning and lenticule extraction were observed during the surgery, and the surgical videos were again reviewed after surgery. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), and spherical equivalence (SE) were noted at 1 month after surgery. The depth and density of the corneal opacities were measured by anterior segment optical coherence tomography (AS-OCT) and the Pentacam anterior eye segment analyzer. RESULTS: All procedures were uneventful and no intraoperative complications were observed. At 1 month after surgery, the UDVA of all patients was 20/25 or better and no patients lost Snellen lines. The mean safety and efficacy indexes were 1.10 ± 0.24 and 1.08 ± 0.16, respectively, at 1 month postoperatively. The mean postoperative spherical equivalent was 0.27 ± 0.23 diopter (D). All eyes were within ±0.75 D and 8 eyes (88.9%) were within ±0.50 D. There was no eccentric corneal topography or abnormal morphology in the corneal caps. The corneal opacities of all patients were within the optical zone. The mean preoperative depths in the deepest areas of corneal opacity were 152 ± 38 µm (range: 86-217 µm); at 1 month after surgery (P < .01), they were 117 ± 28 µm (range: 86-189 µm). The preoperative maximum density of corneal opacity was 48.5 ± 20.7 (range: 20.4 to 85.8); at 1 month after surgery (P > .05), it was 49.8 ± 26.7 (range: 19.8 to 82.5) at 1 month after surgery. CONCLUSION: Patients with corneal opacity can be successfully treated with the SMILE operation. The short-term outcome was good, however the long-term results need further study. TRIAL REGISTRATION: The trial registration number: ChiCTR-ONRC-13003114 , Date of Last Refreshed on: 2016-01-27, Date of registration on 2013-03-17(retrospectively registered).
[Mh] Termos MeSH primário: Opacidade da Córnea/cirurgia
Substância Própria/cirurgia
Cirurgia da Córnea a Laser/métodos
Microcirurgia/métodos
Miopia/cirurgia
Refração Ocular
[Mh] Termos MeSH secundário: Adulto
Opacidade da Córnea/complicações
Opacidade da Córnea/diagnóstico
Substância Própria/patologia
Topografia da Córnea
Feminino
Seguimentos
Seres Humanos
Masculino
Miopia/complicações
Miopia/diagnóstico
Estudos Prospectivos
Fatores de Tempo
Tomografia de Coerência Óptica
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170527
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-017-0474-7


  8 / 3381 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28404468
[Au] Autor:Kalia A; Gandhi T; Chatterjee G; Swami P; Dhillon H; Bi S; Chauhan N; Gupta SD; Sharma P; Sood S; Ganesh S; Mathur U; Sinha P
[Ad] Endereço:Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, USA. Electronic address: akalia@mit.edu.
[Ti] Título:Assessing the impact of a program for late surgical intervention in early-blind children.
[So] Source:Public Health;146:15-23, 2017 May.
[Is] ISSN:1476-5616
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Many blind children in the developing world are unable to obtain timely treatment due to lack of financial and medical resources. Can public health programs that identify and treat such children several years after the onset of blindness enhance their quality of life? The notion that visual development is subject to an early 'critical period' argues against this possibility. However, there are inadequate empirical data from humans on this issue. To address this need, we examined the quality of life of children living in India and who were treated for early-onset blindness (before one year of age), due to cataracts or corneal opacities. STUDY DESIGN: Survey study. METHODS: As part of an ongoing scientific effort named Project Prakash, we screened over 40,000 children in rural northern India to identify those suffering from early-onset blindness. They were provided eye surgeries in a tertiary care ophthalmic center in New Delhi. We subsequently surveyed 64 Prakash children, ranging in age from 5 to 22 years and obtained their responses on a multi-dimensional quality of life questionnaire. RESULTS: Nearly all of the subjects indicated that their quality of life had improved after treatment. Children reported marked enhancement in their mobility, independence, and safety, and also in social integration. Surprisingly, we found no significant correlations between quality of life metrics and factors such as age at treatment, gender, time since treatment, and pre-surgery and post-surgery acuity. CONCLUSIONS: A key question for public health policy makers is whether a program of surgical intervention for older blind children is likely to be beneficial, or if the resources are better spent on rehabilitation via vocational training and assistive devices. The marked improvements in quality of life we find in our data strongly argue for the provision of surgical care regardless of a child's age.
[Mh] Termos MeSH primário: Cegueira/cirurgia
Qualidade de Vida
[Mh] Termos MeSH secundário: Adolescente
Idade de Início
Cegueira/etiologia
Catarata/complicações
Criança
Pré-Escolar
Opacidade da Córnea/complicações
Feminino
Seres Humanos
Índia
Masculino
Avaliação de Programas e Projetos de Saúde
População Rural/estatística & dados numéricos
Inquéritos e Questionários
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE


  9 / 3381 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28374268
[Au] Autor:Di Zazzo A; Bonini S; Crugliano S; Fortunato M
[Ad] Endereço:IRCCS G.B. Bietti Foundation ONLUS, via Livenza n.3, 00198, Rome, Italy. Antonio_dizazzo@yahoo.com.
[Ti] Título:The challenging management of pediatric corneal transplantation: an overview of surgical and clinical experiences.
[So] Source:Jpn J Ophthalmol;61(3):207-217, 2017 May.
[Is] ISSN:1613-2246
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Pediatric keratoplasty is an immense challenge because of the technical complexity of the procedure and the high risk of rejection in young graft recipients. Our aim is to describe the major indications and appropriate timing of corneal transplantation intervention, including a report of our experience and surgical tips, in conjunction with the current literature. METHODS: Review of the literature on indications for keratoplasty in pediatric patients classified as: congenital, traumatic and acquired non-traumatic opacities. We additionally explored the challenges corneal surgeons face in performing this type of surgery and review the most pressing transplant-related problems and their management. RESULTS: Outcomes after pediatric keratoplasty, in terms of visual development, restoration and clarity of the graft, are influenced by peri-operative local and systemic conditions and factors, and by intraoperative management of the transplantation procedure itself. CONCLUSION: Pediatric corneal transplantation is a critical tool for visual restoration and development in young patients with corneal opacities, particularly during the critical period of visual development. Successful management of the significant challenges associated with pediatric keratoplasty requires customized clinical and surgical management of each patient with particular attention paid to proper post-operative rehabilitation.
[Mh] Termos MeSH primário: Córnea/cirurgia
Opacidade da Córnea
Transplante de Córnea/métodos
Acuidade Visual
[Mh] Termos MeSH secundário: Criança
Córnea/patologia
Opacidade da Córnea/patologia
Opacidade da Córnea/fisiopatologia
Opacidade da Córnea/cirurgia
Sobrevivência de Enxerto
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE
[do] DOI:10.1007/s10384-017-0510-4


  10 / 3381 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28207886
[Au] Autor:Feng X; Pi L; Sriram S; Schultz GS; Gibson DJ
[Ad] Endereço:Institute of Wound Research, University of Florida, Gainesville, Florida, United States of America.
[Ti] Título:Connective tissue growth factor is not necessary for haze formation in excimer laser wounded mouse corneas.
[So] Source:PLoS One;12(2):e0172304, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We sought to determine if connective tissue growth factor (CTGF) is necessary for the formation of corneal haze after corneal injury. Mice with post-natal, tamoxifen-induced, knockout of CTGF were subjected to excimer laser phototherapeutic keratectomy (PTK) and the corneas were allowed to heal. The extent of scaring was observed in non-induced mice, heterozygotes, and full homozygous knockout mice and quantified by macrophotography. The eyes from these mice were collected after euthanization for re-genotyping to control for possible Cre-mosaicism. Primary corneal fibroblasts from CTGF knockout corneas were established in a gel plug assay. The plug was removed, simulating an injury, and the rate of hole closure and the capacity for these cells to form light reflecting cells in response to CTGF and platelet-derived growth factor B (PDGF-B) were tested and compared to wild-type cells. We found that independent of genotype, each group of mice was still capable of forming light reflecting haze in the cornea after laser ablation (p = 0.40). Results from the gel plug closure rate in primary cell cultures of knockout cells were not statistically different from serum starved wild-type cells, independent of treatment. Compared to the serum starved wild-type cells, stimulation with PDGF-BB significantly increased the KO cell culture's light reflection (p = 0.03). Most interestingly, both reflective cultures were positive for α-SMA, but the cellular morphology and levels of α-SMA were distinct and not in proportion to the light reflection seen. This new work demonstrates that corneas without CTGF can still form sub-epithelial haze, and that the light reflecting phenotype can be reproduced in culture. These data support the possibilities of growth factor redundancy and that multiple pro-haze pathways exist.
[Mh] Termos MeSH primário: Fator de Crescimento do Tecido Conjuntivo/fisiologia
Córnea/patologia
Lesões da Córnea/etiologia
Opacidade da Córnea/etiologia
Lasers de Excimer/efeitos adversos
Cicatrização
[Mh] Termos MeSH secundário: Animais
Córnea/metabolismo
Lesões da Córnea/metabolismo
Lesões da Córnea/patologia
Opacidade da Córnea/metabolismo
Opacidade da Córnea/patologia
Camundongos
Camundongos Knockout
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ctgf protein, mouse); 139568-91-5 (Connective Tissue Growth Factor)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0172304



página 1 de 339 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde