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Pesquisa : C11.204.299.070 [Categoria DeCS]
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  1 / 196 MEDLINE  
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[PMID]:29419393
[Au] Autor:Ford TJ; Rocchiccioli P
[Ad] Endereço:British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
[Ti] Título:A keen eye for risk.
[So] Source:BMJ;360:j5884, 2018 02 01.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Arco Senil/diagnóstico
Doenças da Córnea/diagnóstico
Doença da Artéria Coronariana/diagnóstico
Hiperlipoproteinemia Tipo II/diagnóstico
Receptores de LDL/genética
[Mh] Termos MeSH secundário: Anticorpos Monoclonais/administração & dosagem
Anticorpos Monoclonais/uso terapêutico
Anticolesterolemiantes/administração & dosagem
Anticolesterolemiantes/uso terapêutico
Arco Senil/etiologia
Colesterol/sangue
Doenças da Córnea/etiologia
Doença da Artéria Coronariana/complicações
Doença da Artéria Coronariana/etiologia
Feminino
Seres Humanos
Inibidores de Hidroximetilglutaril-CoA Redutases/uso terapêutico
Hiperlipoproteinemia Tipo II/sangue
Hiperlipoproteinemia Tipo II/tratamento farmacológico
Hiperlipoproteinemia Tipo II/genética
Injeções Subcutâneas
Meia-Idade
Mutação
Pró-Proteína Convertase 9/antagonistas & inibidores
Xantomatose/diagnóstico
Xantomatose/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Anticholesteremic Agents); 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors); 0 (Receptors, LDL); 97C5T2UQ7J (Cholesterol); EC 3.4.21.- (PCSK9 protein, human); EC 3.4.21.- (Proprotein Convertase 9); LKC0U3A8NJ (evolocumab)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180209
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j5884


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[PMID]:28911992
[Au] Autor:Wong MYZ; Man REK; Gupta P; Lim SH; Lim B; Tham YC; Sabanayagam C; Wong TY; Cheng CY; Lamoureux EL
[Ad] Endereço:Singapore Eye Research Institute, Singapore.
[Ti] Título:Is Corneal Arcus Independently Associated With Incident Cardiovascular Disease in Asians?
[So] Source:Am J Ophthalmol;183:99-106, 2017 Nov.
[Is] ISSN:1879-1891
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To examine the longitudinal relationship between baseline corneal arcus (CA) and incident cardiovascular disease (CVD) in ethnic Indian and Malay adults in Singapore. DESIGN: Population-based cohort study. METHODS: Indian and Malay adults aged 40-80 years were recruited for baseline and 6-year follow-up visits between 2004-2009 and 2010-2015, respectively (follow-up response rate 73.9%). CA was assessed by ophthalmologists using slit-lamp biomicroscopy. The main outcome was self-reported incident CVD, defined as new myocardial infarction, angina pectoris, or stroke, which developed between baseline and follow-up. Multivariable logistic regression models assessed independent associations between baseline CA and incident CVD, adjusting for traditional CVD risk factors including age, sex, serum cholesterol, hypertension, diabetes, and smoking. We further conducted sex-stratified analyses to identify possible effect modifications. RESULTS: Of the total 3637 participants (overall mean [SD] age: 56 [9] years, 46% male) with available follow-up data, without history of CVD at baseline, 208 (5.7%) incident CVD cases were reported. Participants with CA were more likely to have incident CVD (7.5%) than those without (4.9%). After controlling for traditional CVD risk factors, CA was independently associated with incident CVD (odds ratio [95% confidence interval]: 1.52 [1.07-2.16]) in adjusted models. In sex-stratified models, associations between CA and incident CVD were seen in men (1.73 [1.12-2.67]) and not in women (1.05 [0.56-1.97]). CONCLUSIONS: CA is associated with incident CVD, independent of serum lipids and traditional CVD risk factors, in ethnic Malay and Indian men. Our finding suggests that CA is an additional observable indicator of CVD in men.
[Mh] Termos MeSH primário: Arco Senil/etiologia
Doenças Cardiovasculares/etnologia
Córnea/diagnóstico por imagem
Grupos Étnicos
Vigilância da População
Medição de Risco
[Mh] Termos MeSH secundário: Adulto
Distribuição por Idade
Idoso
Idoso de 80 Anos ou mais
Arco Senil/diagnóstico
Arco Senil/etnologia
Doenças Cardiovasculares/complicações
Feminino
Seguimentos
Seres Humanos
Incidência
Masculino
Microscopia Acústica
Meia-Idade
Estudos Prospectivos
Fatores de Risco
Distribuição por Sexo
Singapura/epidemiologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE


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[PMID]:27124777
[Au] Autor:Ayhan Z; Ozturk T; Kaya M; Arikan G; Gunenc U
[Ad] Endereço:Department of Ophthalmology, Dokuz Eylul University School of Medicine, Izmir, Turkey.
[Ti] Título:Corneal Biomechanical Properties in Patients With Arcus Senilis.
[So] Source:Cornea;35(7):980-2, 2016 Jul.
[Is] ISSN:1536-4798
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To compare the corneal biomechanical properties and intraocular pressure (IOP) levels in patients with and without arcus senilis (AS). METHODS: Ocular response analyzer measurements were performed on the right eyes of 37 patients with AS (group 1) and 37 control eyes (group 2). Corneal hysteresis, corneal resistance factor, Goldmann-correlated IOP, and corneal compensated IOP were recorded with Ocular response analyzer. Spherical equivalent value of the refractive errors, axial length, central corneal thickness, and IOP measured with Goldmann applanation tonometer were noted for each study eyes. Statistical analyses were performed with Student t, Kruskal-Wallis, and Pearson correlation tests. RESULTS: Mean age was 67.6 ± 9.8 years in group 1 and 65.3 ± 8.1 years in group 2 (P = 0.308). Mean corneal hysteresis and corneal resistance factor readings were 9.8 ± 0.9 versus 10.6 ± 0.8 (P < 0.001) and 10.05 ± 1.07 versus 10.9 ± 0.9 (P < 0.001) in groups 1 and 2, respectively. Mean corneal compensated IOP and Goldmann-correlated IOP values were found as 16.1 ± 3.3 mm Hg versus 15.8 ± 2.6 mm Hg (P = 0.719) and 15.1 ± 3.3 mm Hg versus 15.0 ± 2.6 mm Hg (P = 0.912) in groups 1 and 2, respectively. There was no statistical difference in IOP measured with Goldmann applanation tonometer, central corneal thickness, spherical equivalent value of the refractive error, axial length measurements, and mean keratometry readings between the 2 groups (P = 0.983, P = 0.289, P = 0.938, P = 0.886, P = 0.07, respectively). CONCLUSIONS: The mean corneal hysteresis and corneal resistance factor values of eyes with AS were lower when compared with the controls. This study demonstrated that AS may change the corneal biomechanical properties.
[Mh] Termos MeSH primário: Arco Senil/fisiopatologia
Córnea/fisiologia
Elasticidade/fisiologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Comprimento Axial do Olho
Fenômenos Biomecânicos
Feminino
Seres Humanos
Pressão Intraocular/fisiologia
Masculino
Meia-Idade
Estudos Prospectivos
Tonometria Ocular
Acuidade Visual/fisiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160429
[St] Status:MEDLINE
[do] DOI:10.1097/ICO.0000000000000856


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[PMID]:26543100
[Au] Autor:Ogura M; Hori M; Harada-Shiba M
[Ad] Endereço:From the Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan. enustasam@ncvc.go.jp.
[Ti] Título:Association Between Cholesterol Efflux Capacity and Atherosclerotic Cardiovascular Disease in Patients With Familial Hypercholesterolemia.
[So] Source:Arterioscler Thromb Vasc Biol;36(1):181-8, 2016 Jan.
[Is] ISSN:1524-4636
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Patients with familial hypercholesterolemia (FH) are at high risk for premature atherosclerotic cardiovascular disease (ASCVD), especially because of long-term exposure to high low-density lipoprotein cholesterol levels. It has been reported that low-density lipoprotein-lowering therapy delays the onset of ASCVD. However, it still remains difficult to prevent it. Therefore, novel biomarkers and therapeutic targets are necessary to evaluate and prevent atherosclerosis in FH. The aim of this study was to investigate associations of cholesterol efflux capacity with the presence of ASCVD and clinical features in patients with heterozygous FH. APPROACH AND RESULTS: We measured cholesterol efflux capacity in 227 patients with heterozygous FH under pharmaceutical treatment. Seventy-six (33.5%) of them were known to have ASCVD. In a logistic-regression analysis adjusted for risk factors, increased efflux capacity was associated with decreased risk of ASCVD even after the addition of high-density lipoprotein cholesterol level as a covariate (odds ratio per 1-SD increase, 0.95; 95% confidence interval, 0.90-0.99; P<0.05). Decreased cholesterol efflux capacity was associated with the presence of corneal arcus after adjusting for age and sex. In addition, inverse relationships between cholesterol efflux capacity and Achilles tendon thickness, as well as carotid intima-media thickness, were observed after adjustment for age, sex, and traditional cardiovascular risk factors. CONCLUSIONS: Cholesterol efflux capacity was independently and inversely associated with the presence of ASCVD in heterozygous FH. In view of residual risks after treatment with statins, cholesterol efflux capacity might be a novel biomarker and a therapeutic target for preventing atherosclerosis in patients with FH.
[Mh] Termos MeSH primário: Aterosclerose/etiologia
HDL-Colesterol/sangue
Hiperlipoproteinemia Tipo II/diagnóstico
[Mh] Termos MeSH secundário: Tendão do Calcâneo/diagnóstico por imagem
Adulto
Idoso
Arco Senil/sangue
Arco Senil/etiologia
Arco Senil/genética
Doenças Assintomáticas
Aterosclerose/sangue
Aterosclerose/diagnóstico
Aterosclerose/genética
Biomarcadores/sangue
Doenças das Artérias Carótidas/sangue
Doenças das Artérias Carótidas/etiologia
Doenças das Artérias Carótidas/genética
Espessura Intima-Media Carotídea
Estudos Transversais
Feminino
Predisposição Genética para Doença
Heterozigoto
Seres Humanos
Hiperlipoproteinemia Tipo II/sangue
Hiperlipoproteinemia Tipo II/genética
Modelos Lineares
Modelos Logísticos
Masculino
Meia-Idade
Mutação
Razão de Chances
Fenótipo
Pró-Proteína Convertase 9
Pró-Proteína Convertases/genética
Radiografia
Receptores de LDL/genética
Serina Endopeptidases/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers); 0 (Cholesterol, HDL); 0 (LDLR protein, human); 0 (Receptors, LDL); EC 3.4.21.- (PCSK9 protein, human); EC 3.4.21.- (Proprotein Convertase 9); EC 3.4.21.- (Proprotein Convertases); EC 3.4.21.- (Serine Endopeptidases)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151107
[St] Status:MEDLINE
[do] DOI:10.1161/ATVBAHA.115.306665


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[PMID]:24547910
[Au] Autor:Molho-Pessach V; Mechoulam H; Siam R; Babay S; Ramot Y; Zlotogorski A
[Ad] Endereço:a Department of Dermatology .
[Ti] Título:Ophthalmologic Findings in H Syndrome: A Unique Diagnostic Clue.
[So] Source:Ophthalmic Genet;36(4):365-8, 2015.
[Is] ISSN:1744-5094
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: H syndrome is an autosomal recessive histiocytosis with multisystemic involvement caused by mutations in the SLC29A3 gene. The term H syndrome was coined to denote the major clinical findings which include hyperpigmentation, hypertrichosis, hearing loss, hepatosplenomegaly, hypogonadism, hyperglycemia/diabetes mellitus and hallux valgus/flexion contractures. Almost 100 individuals affected with this disorder have been reported, however, a thorough evaluation of the ophthalmologic features of H syndrome has not yet been performed. MATERIALS AND METHODS: Ophthalmic examination of a 50-year-old male with H syndrome. Mutation analysis of SLC29A3 was also performed in this patient. RESULTS: Ophthalmic findings included; shallow orbits with exorbitism, bilateral pterygium, limbal thickening, corneal arcus and cortical cataract. We also review ophthalmologic findings in previously reported H syndrome patients. CONCLUSIONS: The presence of dilated lateral scleral vessels, corneal arcus and shallow orbits should raise the suspicion of H syndrome, especially when seen in young age.
[Mh] Termos MeSH primário: Arco Senil/diagnóstico
Catarata/diagnóstico
Contratura/diagnóstico
Exoftalmia/diagnóstico
Perda Auditiva Neurossensorial/diagnóstico
Histiocitose/diagnóstico
Limbo da Córnea/patologia
Pterígio/diagnóstico
[Mh] Termos MeSH secundário: Contratura/genética
Análise Mutacional de DNA
Perda Auditiva Neurossensorial/genética
Histiocitose/genética
Seres Humanos
Masculino
Meia-Idade
Proteínas de Transporte de Nucleosídeos/genética
Esclera/irrigação sanguínea
Doenças Vasculares/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Nucleoside Transport Proteins); 0 (SLC29A3 protein, human)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:151218
[Lr] Data última revisão:
151218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140220
[St] Status:MEDLINE
[do] DOI:10.3109/13816810.2014.886272


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[PMID]:25118951
[Au] Autor:Hashemi H; Khabazkhoob M; Emamian MH; Shariati M; Fotouhi A
[Ad] Endereço:Noor Ophthalmology Research Center, Noor Eye Hospital , Tehran , Iran .
[Ti] Título:A population-based study of corneal arcus and its risk factors in Iran.
[So] Source:Ophthalmic Epidemiol;21(5):339-44, 2014 Oct.
[Is] ISSN:1744-5086
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To determine the prevalence of corneal arcus, its risk factors, and its relationship to ocular and visual indices. METHODS: In this cross-sectional study, 300 clusters were randomly selected from Shahroud in the north of Iran, using multistage sampling. A total of 20 people were invited to participate from each cluster. After enrollment, all optometric, biometric and ophthalmic exams were conducted on site. RESULTS: Of 6311 people invited, 5190 (82.2%) participated in the study. The prevalence of corneal arcus was 23.3% (95% confidence interval, CI, 22.1-24.6), and 98.4% were bilateral cases. The prevalence of corneal arcus was higher in men (odds ratio, OR, 2.02, 95% CI 1.8-2.3, p < 0.001) and increased with age (OR 1.1/year, p < 0.001). In a multivariable-adjusted regression model, age (OR 1.1/year, p = 0.006), male sex (OR 1.30, p = 0.001), diabetes (OR 0.7, p < 0.001), smoking (OR 1.5, p = 0.003), outdoor activity (OR 1.4, p = 0.006), systolic blood pressure (OR 1.01, p = 0.012), and diastolic blood pressure (OR 0.99, p = 0.016) were significantly correlated with corneal arcus. Including biometric components in another model, corneal thickness (OR 0.99, p < 0.001), anterior chamber depth (OR 0.68, p < 0.001) and corneal radius of curvature (OR 1.59, p < 0.001) were significantly correlated with corneal arcus. CONCLUSION: This study adds valuable information to the epidemiology of corneal arcus in Iran and the Middle East. In people aged over 60 years, nearly 50% of the study population had corneal arcus. Older age, male sex, smoking, and systolic hypertension were risk factors for corneal arcus. Corneal arcus was also associated with thin and flat corneas and shallow anterior chamber depth.
[Mh] Termos MeSH primário: Arco Senil/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Distribuição por Idade
Envelhecimento/fisiologia
Arco Senil/diagnóstico
Arco Senil/fisiopatologia
Biometria
Estudos Transversais
Feminino
Seres Humanos
Irã (Geográfico)/epidemiologia
Masculino
Meia-Idade
Prevalência
Fatores de Risco
Distribuição por Sexo
Fatores Sexuais
Acuidade Visual/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1503
[Cu] Atualização por classe:140911
[Lr] Data última revisão:
140911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140815
[St] Status:MEDLINE
[do] DOI:10.3109/09286586.2014.949782


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[PMID]:25053660
[Au] Autor:Cuchel M; Bruckert E; Ginsberg HN; Raal FJ; Santos RD; Hegele RA; Kuivenhoven JA; Nordestgaard BG; Descamps OS; Steinhagen-Thiessen E; Tybjærg-Hansen A; Watts GF; Averna M; Boileau C; Borén J; Catapano AL; Defesche JC; Hovingh GK; Humphries SE; Kovanen PT; Masana L; Pajukanta P; Parhofer KG; Ray KK; Stalenhoef AF; Stroes E; Taskinen MR; Wiegman A; Wiklund O; Chapman MJ; European Atherosclerosis Society Consensus Panel on Familial Hypercholesterolaemia
[Ad] Endereço:Institute for Translational Medicine and Therapeutics, University of Pennsylvania, 8039 Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA mcuchel@mail.med.upenn.edu.
[Ti] Título:Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society.
[So] Source:Eur Heart J;35(32):2146-57, 2014 Aug 21.
[Is] ISSN:1522-9645
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: Homozygous familial hypercholesterolaemia (HoFH) is a rare life-threatening condition characterized by markedly elevated circulating levels of low-density lipoprotein cholesterol (LDL-C) and accelerated, premature atherosclerotic cardiovascular disease (ACVD). Given recent insights into the heterogeneity of genetic defects and clinical phenotype of HoFH, and the availability of new therapeutic options, this Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society (EAS) critically reviewed available data with the aim of providing clinical guidance for the recognition and management of HoFH. METHODS AND RESULTS: Early diagnosis of HoFH and prompt initiation of diet and lipid-lowering therapy are critical. Genetic testing may provide a definitive diagnosis, but if unavailable, markedly elevated LDL-C levels together with cutaneous or tendon xanthomas before 10 years, or untreated elevated LDL-C levels consistent with heterozygous FH in both parents, are suggestive of HoFH. We recommend that patients with suspected HoFH are promptly referred to specialist centres for a comprehensive ACVD evaluation and clinical management. Lifestyle intervention and maximal statin therapy are the mainstays of treatment, ideally started in the first year of life or at an initial diagnosis, often with ezetimibe and other lipid-modifying therapy. As patients rarely achieve LDL-C targets, adjunctive lipoprotein apheresis is recommended where available, preferably started by age 5 and no later than 8 years. The number of therapeutic approaches has increased following approval of lomitapide and mipomersen for HoFH. Given the severity of ACVD, we recommend regular follow-up, including Doppler echocardiographic evaluation of the heart and aorta annually, stress testing and, if available, computed tomography coronary angiography every 5 years, or less if deemed necessary. CONCLUSION: This EAS Consensus Panel highlights the need for early identification of HoFH patients, prompt referral to specialized centres, and early initiation of appropriate treatment. These recommendations offer guidance for a wide spectrum of clinicians who are often the first to identify patients with suspected HoFH.
[Mh] Termos MeSH primário: Hiperlipoproteinemia Tipo II/diagnóstico
[Mh] Termos MeSH secundário: Anticolesterolemiantes/uso terapêutico
Arco Senil/etiologia
Aterosclerose/diagnóstico
Remoção de Componentes Sanguíneos/métodos
Doenças Cardiovasculares/etiologia
LDL-Colesterol/metabolismo
Diagnóstico Diferencial
Diagnóstico Precoce
Frequência do Gene/genética
Heterogeneidade Genética
Homozigoto
Seres Humanos
Hiperlipoproteinemia Tipo II/genética
Hiperlipoproteinemia Tipo II/terapia
Transplante de Fígado/métodos
Mutação/genética
Linhagem
Fenótipo
Guias de Prática Clínica como Assunto
Xantomatose/etiologia
[Pt] Tipo de publicação:CONSENSUS DEVELOPMENT CONFERENCE; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anticholesteremic Agents); 0 (Cholesterol, LDL)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140724
[St] Status:MEDLINE
[do] DOI:10.1093/eurheartj/ehu274


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[PMID]:25035360
[Au] Autor:Sharma YK; Gupta A; Chaudhari ND
[Ti] Título:Pediatric tuberous xanthomas.
[So] Source:Indian J Dermatol Venereol Leprol;80(4):335, 2014 Jul-Aug.
[Is] ISSN:0973-3922
[Cp] País de publicação:India
[La] Idioma:eng
[Mh] Termos MeSH primário: Arco Senil/diagnóstico
Hiperlipoproteinemia Tipo II/diagnóstico
Xantogranuloma Juvenil/diagnóstico
[Mh] Termos MeSH secundário: Arco Senil/etiologia
Criança
Seres Humanos
Hiperlipoproteinemia Tipo II/complicações
Masculino
Xantogranuloma Juvenil/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1504
[Cu] Atualização por classe:140718
[Lr] Data última revisão:
140718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140719
[St] Status:MEDLINE
[do] DOI:10.4103/0378-6323.136904


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[PMID]:24314439
[Au] Autor:Macchiaiolo M; Buonuomo PS; Valente P; Rana I; Lepri FR; Gonfiantini MV; Bartuli A
[Ad] Endereço:Rare Diseases and Medical Genetics, Bambino Gesù Children's Hospital, Rome, Italy.
[Ti] Título:Corneal arcus as first sign of familial hypercholesterolemia.
[So] Source:J Pediatr;164(3):670, 2014 Mar.
[Is] ISSN:1097-6833
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Arco Senil/patologia
Hiperlipoproteinemia Tipo II/diagnóstico
[Mh] Termos MeSH secundário: Arco Senil/etiologia
Pré-Escolar
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1404
[Cu] Atualização por classe:140224
[Lr] Data última revisão:
140224
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:131210
[St] Status:MEDLINE


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[PMID]:24306057
[Au] Autor:Acquart S; Campolmi N; He Z; Pataia G; Jullienne R; Garraud O; Nguyen F; Péoc'h M; Lépine T; Thuret G; Gain P
[Ad] Endereço:Eye Bank of Saint-Etienne, Auvergne Loire Blood Center, Saint-Étienne, France.
[Ti] Título:Non-invasive measurement of transparency, arcus senilis, and scleral rim diameter of corneas during eye banking.
[So] Source:Cell Tissue Bank;15(3):471-82, 2014 Sep.
[Is] ISSN:1573-6814
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We developed a non-invasive device to quantify transparency (T), clear corneal diameter (CCD) excluding arcus senilis, and scleral rim diameter (SRD) of stored corneas. The T value (expressed in % on a relative scale), based on the modulation transfer function principle, referred to the ratio of local contrasts of a special LED backlit chart measured with and without cornea. CCD and SRD (in mm) were automatically calculated by morphologic operations. Firstly, we assessed measurement reproducibility. We then determined the agreement of T and CCD values with 3-level scores given independently by three experts on 179 scientific corneas. Thirdly, an eye bank was equipped with the device, and 358 consecutive organ-cultured (OC) corneas were tested for donor- and storage- related factors possibly influencing T and CCD. Reproducibility of T, CCD and SRD measurements was high, with intraclass correlation coefficients of 0.982, 0.886, and 0.999 respectively. Capacity to discriminate the three levels of transparency and arcus senilis was good, with T of 20.0 (10.0-33.6), 38.3 (24.3-75.4) and 57.9 (33.9-90.0) % respectively for T deemed poor, average, and good (P < 0.001), and CCD of 9.8 (7.3-10.6), 10.5 (8.2-11.5), and 11.1 (9.9-12.0) mm respectively for arcus senilis deemed prominent, moderate or absent (P < 0.001). T was correlated with neither donor age nor endothelial cell density nor storage time, but slightly worsened during OC for corneas assessed twice. In conclusion, the device, which can be easily integrated in the facilities of an eye bank, provides reliable objective measurement of T, CCD, and SRD. This could be a useful tool for standardizing quality assessment of stored corneas and consequently optimizing their selection for penetrating, endothelial or anterior lamellar keratoplasty.
[Mh] Termos MeSH primário: Arco Senil/diagnóstico
Córnea/citologia
Transplante de Córnea
Epitélio Posterior/citologia
Bancos de Olhos
Preservação de Órgãos
[Mh] Termos MeSH secundário: Transplante de Córnea/métodos
Seres Humanos
Preservação de Órgãos/instrumentação
Preservação de Órgãos/métodos
Reprodutibilidade dos Testes
Doadores de Tecidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1506
[Cu] Atualização por classe:140827
[Lr] Data última revisão:
140827
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131206
[St] Status:MEDLINE
[do] DOI:10.1007/s10561-013-9414-9



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