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[PMID]:27772645
[Au] Autor:Jeng BH; Farid M; Patel SV; Schwab IR
[Ad] Endereço:Baltimore, Maryland. Electronic address: bjeng@som.umaryland.edu.
[Ti] Título:Corneal Cross-linking for Keratoconus: A Look at the Data, the Food and Drug Administration, and the Future.
[So] Source:Ophthalmology;123(11):2270-2272, 2016 11.
[Is] ISSN:1549-4713
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Reagentes para Ligações Cruzadas
Ceratocone/tratamento farmacológico
Fotoquimioterapia
Fármacos Fotossensibilizantes/uso terapêutico
Riboflavina/uso terapêutico
United States Food and Drug Administration/tendências
[Mh] Termos MeSH secundário: Ensaios Clínicos como Assunto
Colágeno/metabolismo
Substância Própria/metabolismo
Aprovação de Drogas
Previsões
Seres Humanos
Ceratocone/metabolismo
Projetos de Pesquisa
Raios Ultravioleta
Estados Unidos
[Pt] Tipo de publicação:EDITORIAL
[Nm] Nome de substância:
0 (Cross-Linking Reagents); 0 (Photosensitizing Agents); 9007-34-5 (Collagen); TLM2976OFR (Riboflavin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29357819
[Au] Autor:Kodama-Takahashi A; Fukuda M; Sugioka K; Kobayashi A; Shimomura Y
[Ad] Endereço:Department of Ophthalmology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama City, Osaka, 589-8511, Japan. akodama@med.kindai.ac.jp.
[Ti] Título:Spontaneous reattachment of dislocated endothelial graft after non-Descemet stripping automated endothelial keratoplasty: a case report.
[So] Source:BMC Ophthalmol;18(1):14, 2018 Jan 22.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Graft detachment is a complication of non-Descemet stripping automated endothelial keratoplasty (nDSAEK). We report a case of spontaneous reattachment of an extensively dislocated graft after nDSAEK. CASE PRESENTATION: A 54-year-old male underwent penetrating keratoplasty (PKP) for keratoconus in his left eye in 2001. Following graft opacity due to rejection, a second PKP was implemented in May 2014. The graft was kept in good condition after the reoperation and yet, visual acuity (VA) declined due to cataract. PEA+IOL was then performed in May 2015. Because edema appeared in the graft 6 months after the PEA+IOL, nDSAEK was carried out in May 2016. Although the donor graft well attached immediately after the nDSAEK, the graft was almost completely dislocated 3 h later except a temporal part. Air was reinjected into the anterior chamber on the following day and the detachment was resolved. Despite of the treatment, about 1/5 of the graft remained detached and the detachment deteriorated to 3/4 of the graft 9 days later. Because the patient could not decide whether to undergo another operation immediately, we decided to follow him up first and found that the partially detached graft reattached spontaneously 1 month later during the follow-up. Although the cornea had a mild edema remaining in the superior temporal area, his BCVA improved to 1.0. Three months later, the graft remained in position and the cornea kept its transparency. CONCLUSIONS: Spontaneous reattachment was observed during the follow-up in a case that had shown a comparatively extensive graft dislocation after nDSAEK.
[Mh] Termos MeSH primário: Ceratoplastia Endotelial com Remoção da Lâmina Limitante Posterior/efeitos adversos
Sobrevivência de Enxerto
Ceratocone/cirurgia
Complicações Pós-Operatórias/diagnóstico
[Mh] Termos MeSH secundário: Câmara Anterior
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Remissão Espontânea
Estudos Retrospectivos
Falha de Tratamento
Acuidade Visual
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180124
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0684-7


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[PMID]:29422750
[Au] Autor:Bussières N; Ababneh OH; Abu Ameerh MA; Al Bdour MD
[Ad] Endereço:Department of Vision Rehabilitation, Faculty of Applied Medical Sciences, German Jordanian University, Amman, Jordan.
[Ti] Título:Keratoconus Asymmetry between Both Eyes Based on Corneal Tomography.
[So] Source:Middle East Afr J Ophthalmol;24(4):171-176, 2017 Oct-Dec.
[Is] ISSN:0975-1599
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To characterize the asymmetry between both eyes in patients with keratoconus based on corneal tomography. MATERIALS AND METHODS: All patients with keratoconus who presented to the eye clinic at Jordan University Hospital between January 2008 and November 2011 were included in the study. Using computerized corneal tomography, the keratometric values and indices of both eyes of participants with keratoconus and normal controls were compared. For both eyes to be considered symmetrical, the difference between the mean curvature power (Km), flat curvature power (K1), or steep curvature power (K2) in both eyes was equal to or <2.5 diopters, and the difference between the thinnest corneal points was equal to or <25.0 µm between both eyes. RESULTS: Ninety-eight patients with keratoconus and 49 normal participants were evaluated. The mean age of the participants was 26.3 ± 6.6 years. The results showed two populations of patients with keratoconus: one with asymmetrical corneas who were more affected by the disease and another with symmetrical corneas. As the disease severity increased, the differences between the two eyes increased for patients with the asymmetrical form, while both corneas of patients with the symmetrical form were similar. CONCLUSIONS: Corneal tomography identified two forms of keratoconus: symmetrical and asymmetrical. The latter tended to be more severe and occurred in a younger age group. Questions remain about whether the two keratoconic forms are specific to the Middle Eastern population and whether there are ethnic or demographic forms of the disease.
[Mh] Termos MeSH primário: Córnea/patologia
Ceratocone/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Topografia da Córnea
Feminino
Seres Humanos
Masculino
Meia-Idade
Tomografia Computadorizada por Raios X
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE
[do] DOI:10.4103/meajo.MEAJO_311_16


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[PMID]:29227515
[Au] Autor:Carriazo C; Cosentino MJ
[Ti] Título:A Novel Corneal Remodeling Technique for the Management of Keratoconus.
[So] Source:J Refract Surg;33(12):854-856, 2017 Dec 01.
[Is] ISSN:1081-597X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To describe a novel technique to reshape the ectatic cornea by means of crescent keratectomy performed with an excimer laser using a mask. METHODS: A crescent-shaped perforation at the base of the mask allowed the laser ablation to be directed only to the intended region, shielding the remaining cornea. This technique was performed in 3 eyes of 3 patients with keratoconus grade 2 to 3. Arcs of 180° and 360° had been performed depending on the severity of the keratoconus. The edges of the crescent were closed by 10-0 nylon interrupted sutures. RESULTS: At 1 year postoperatively, all cases showed improvement in visual acuity, keratometry, and corneal topography. The treatment also reduced optical aberrations and shortened the anterior chamber depth. CONCLUSIONS: Although the preliminary results are promising, there is a need to standardize a nomogram of this technique for treating keratoconus. [J Refract Surg. 2017;33(12):854-856.].
[Mh] Termos MeSH primário: Córnea/fisiologia
Cirurgia da Córnea a Laser/métodos
Ceratocone/cirurgia
Lasers de Excimer/uso terapêutico
Fenômenos Fisiológicos Oculares
[Mh] Termos MeSH secundário: Adulto
Topografia da Córnea
Feminino
Seres Humanos
Ceratocone/fisiopatologia
Masculino
Refração Ocular/fisiologia
Acuidade Visual/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.3928/1081597X-20171004-05


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[PMID]:29227513
[Au] Autor:Vinciguerra R; Romano V; Arbabi EM; Brunner M; Willoughby CE; Batterbury M; Kaye SB
[Ti] Título:In Vivo Early Corneal Biomechanical Changes After Corneal Cross-linking in Patients With Progressive Keratoconus.
[So] Source:J Refract Surg;33(12):840-846, 2017 Dec 01.
[Is] ISSN:1081-597X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To report early corneal biomechanical changes after corneal cross-linking (CXL) in patients with keratoconus. METHODS: Thirty-four eyes of 34 patients undergoing CXL for progressive keratoconus were included in this prospective clinical study. Dynamic corneal response (DCR) parameters obtained with the Corvis ST (OCULUS Optikgeräte GmbH; Wetzlar, Germany) were assessed at baseline (day of CXL) and after 1 month of follow-up; conversely, corneal tomography with the Pentacam (OCULUS Optikgeräte GmbH) was assessed at baseline and at 1, 3, and 6 months after CXL. RESULTS: At the last follow-up visit (123.7 ± 69.6 days), all morphological parameters including steepest point (Kmax) and thinnest corneal thickness (ThCT) indicated stabilization of keratoconus (P > .05). Comparative analyses showed a rise of corneal stiffness demonstrated by a significant increase of Stiffness Parameter A1 (SP-A1) and Highest Concavity (SP-HC) and a significant decrease of Inverse Concave Radius (1/R) and Deformation Amplitude Ratio (DA Ratio) (P < .05). There was a significant correlation between the preoperative keratoconus characteristics (Kmax, Belin/Ambrósio final D value [BAD-D], and ThCT) and the DCR parameters (P < .05). Kmax and BAD-D showed a significant positive correlation with DA Ratio, Deflection Amplitude (DefA), and 1/R and a significant negative correlation with SPA1 and SP-HC. ThCT showed a significant positive correlation with SP-A1 and SP-HC and a significant negative correlation with DA Ratio, DefA, and 1/R. CONCLUSIONS: This study suggests that the new DCR parameters of the Corvis ST are able to detect early changes in biomechanics following CXL and those that are measurable before corneal shape modifications take place. Based on these results, the authors suggest the use of these metrics to assess the early efficacy of cross-linking. [J Refract Surg. 2017;33(12):840-846.].
[Mh] Termos MeSH primário: Córnea/fisiologia
Reagentes para Ligações Cruzadas
Elasticidade/fisiologia
Ceratocone/tratamento farmacológico
Fotoquimioterapia
Fármacos Fotossensibilizantes/uso terapêutico
Riboflavina/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Fenômenos Biomecânicos
Colágeno/metabolismo
Substância Própria/metabolismo
Topografia da Córnea
Feminino
Seres Humanos
Ceratocone/metabolismo
Ceratocone/fisiopatologia
Masculino
Estudos Prospectivos
Raios Ultravioleta
Acuidade Visual/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cross-Linking Reagents); 0 (Photosensitizing Agents); 9007-34-5 (Collagen); TLM2976OFR (Riboflavin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.3928/1081597X-20170922-02


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[PMID]:29439700
[Au] Autor:Jian W; Shen Y; Chen Y; Tian M; Zhou X
[Ad] Endereço:The Eye and ENT Hospital of Fudan University, Shanghai, China.
[Ti] Título:Ocular dimensions of the Chinese adolescents with keratoconus.
[So] Source:BMC Ophthalmol;18(1):43, 2018 Feb 13.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Adolescent KC is a special segment of the general KC population because an adolescents's eyes are still susceptible to blurred vision and optical defocus during the sensitive period of ocular and visual development. In the present study, we evaluated the ocular dimensions of 53 KC adolescents. METHODS: One hundred and six KC eyes of 53 (42 boys and 11 girls) KC adolescents (age 15.5 ± 1.7 years, range 11 to 18) were involved in this retrospective study. The eye with more severe KC (Severe Group) of each patient was compared with their less affected eye (Mild Group). Optical axial length (OAL) was measured by optical coherence biometry (IOL-master). Central corneal thickness, anterior chamber depth (ACD), flat keratometry value, steep keratometry value, and maximum keratometry value were assessed with an anterior segment analyzer (Pentacam HR). Anterior segment length (ASL) was manually measured from the 25 scheimpflug images captured by the Pentacam HR with the mean value recorded. The posterior segment length (PSL) was calculated with the formula "PSL = OAL-ASL". RESULTS: The mean ACD, OAL, ASL, and PSL values of the Severe Group were 3.51 ± 0.32 mm, 24.76 ± 1.24 mm, 4.01 ± 0.30 mm and 20.76 ± 1.15 mm.While those of the Mild Group were 3.36 ± 0.29 mm, 24.97 ± 1.40 mm, 3.94 ± 0.35 mm and 21.03 ± 1.31 mm. The Severe Group has significantly higher ACD (t = 4.539, P < 0.001) value but lower OAL (t = - 3.120, P = 0.003) and PSL (t = - 4.537, P < 0.001) values when compared with those of the Mild Group. For the Severe Group, the Kmax values were significantly correlated with the SE values (R = - 0.385, P = 0.004), the ACD values (R = 0.375, P = 0.006), the ASL values (R = 0.308, P = 0.025) and the PSL values (R = - 0.317, P = 0.021), but not with the OAL values (R = - 0.220, P = 0.114). In the Mild Group, the Kmax values were negatively correlated with the SE (R = - 0.577, P < 0.001), OAL(R = - 0.533, P < 0.001), and PSL (R = - 0.523, P < 0.001) values, but not with ACD (R = - 0.110, P = 0.434) or ASL (R = - 0.182, P = 0.192) values. CONCLUSIONS: For adolescent KC, the more keratoconic eyes may be characterized by deeper ACD but shorter OAL and PSL, when compared with the less affected ones.
[Mh] Termos MeSH primário: Câmara Anterior/patologia
Comprimento Axial do Olho/patologia
Ceratocone/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Grupo com Ancestrais do Continente Asiático/etnologia
Biometria
Criança
China/epidemiologia
Topografia da Córnea
Feminino
Seres Humanos
Ceratocone/epidemiologia
Masculino
Refração Ocular
Estudos Retrospectivos
Tomografia de Coerência Óptica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180218
[Lr] Data última revisão:
180218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0713-6


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[PMID]:29328565
[Au] Autor:Jovanovic V; Nikolic L
[Ti] Título:Urrets-Zavalia syndrome after deep anterior lamellar keratoplasty
[So] Source:Vojnosanit Pregl;73(10):973-5, 2016 Oct.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Introduction: Urrets-Zavalia syndrome is an uncommon complication of the deep anterior lamellar keratoplasty in keratoconus. The manifestations of this syndrome are an irreversible mydriasis, iris atrophy and secondary glaucoma. Case report: Deep anterior lamellar keratoplasty was done for keratoconus with a presumably healed corneal hydrops in a 21-year-old Caucasian man. The graft remained clear, but the surgery was complicated by a fixed, dilated pupil, patches of iris atrophy, ectropium of the iris pigment layer and glaukomflecken in the lens. Conclusion: Although safer than penetrating keratoplasty, the deep anterior lamellar by not trying to secure an unhealed Descemet's membrane with air. Instead, a new Descemet's membrane transplanted within a penetrating graft is a safer choice.
[Mh] Termos MeSH primário: Transplante de Córnea/efeitos adversos
Glaucoma/etiologia
Doenças da Íris/etiologia
Ceratocone/cirurgia
Midríase/etiologia
[Mh] Termos MeSH secundário: Atrofia
Glaucoma/diagnóstico
Seres Humanos
Iris/patologia
Doenças da Íris/diagnóstico
Ceratocone/diagnóstico
Masculino
Midríase/diagnóstico
Síndrome
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.2298/VSP141109088J


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[PMID]:28742621
[Au] Autor:Imbornoni LM; Padmanabhan P; Belin MW; Deepa M
[Ad] Endereço:*Department of Ophthalmology and Vision Science, University of Arizona, Tucson, AZ; †Department of Cornea and Refractive Surgery, Medical Research Foundation, Chennai, India.
[Ti] Título:Long-Term Tomographic Evaluation of Unilateral Keratoconus.
[So] Source:Cornea;36(11):1316-1324, 2017 Nov.
[Is] ISSN:1536-4798
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To report 5 cases of advanced unilateral keratoconus documented by sequential tomographic evaluation. METHODS: Retrospective review over a 10-year period at a single practice identifying patients with unilateral keratoconus by advanced imaging throughout the follow-up period. RESULTS: Five patients were identified with progressive keratoconus in 1 eye and no changes in the fellow eye based on full tomographic evaluation and analysis of both anterior and posterior corneal surfaces and corneal thickness with a mean follow-up period of 59 months (range 39-86). CONCLUSIONS: Keratoconus is believed to be a bilateral disease that can present asymmetrically. We present 5 cases that appear to be true unilateral keratoconus with no associated mechanical environmental factors.
[Mh] Termos MeSH primário: Córnea/patologia
Topografia da Córnea
Ceratocone/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Paquimetria Corneana
Feminino
Seguimentos
Lateralidade Funcional
Seres Humanos
Masculino
Estudos Retrospectivos
Acuidade Visual
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1097/ICO.0000000000001295


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[PMID]:29381972
[Au] Autor:Cantemir A; Alexa AI; Galan BG; Anton N; Ciuntu RE; Danielescu C; Chiselita D; Costin D
[Ad] Endereço:Grigore T. Popa University of Medicine and Pharmacy.
[Ti] Título:Outcomes of iontophoretic corneal collagen crosslinking in keratoconic eyes with very thin corneas.
[So] Source:Medicine (Baltimore);96(47):e8758, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The purpose of this retrospective study was to report the results of iontophoretic corneal collagen crosslinking (I-CXL) with riboflavin and ultraviolet A irradiation in patients affected by keratoconus, each with thinnest pachymetry values of <400 µ (with epithelium) and not treatable using standard epithelium-off technique.Fifteen eyes of 15 patients affected by progressive keratoconus and with thinnest pachymetry values <400 µ underwent I-CXL. The uncorrected (UDVA) and corrected (CDVA) distance visual acuity, maximum and minimum keratometry (K max and K min) readings, corneal thickness at the thinnest point (CTTP), endothelial cell density (ECD), and intraocular pressure (IOP) were assessed before I-CXL, at 1, 3, 6, and 12 months postoperatively.The mean UDVA and CDVA significantly increased 12 months after I-CXL (P = .002 for both comparisons). The K max readings significantly decreased at 6 and 12 months postoperatively (P = .04 and P = .02, respectively). The mean CTTP improved at the end of the follow-up (P = .008). ECD was unchanged. No side effects or damage to the limbal region was observed during the follow-up period.I-CXL has been proved to be effective in halting keratoconus progression in eyes with very thin corneas, with no side effects during the follow-up period. This procedure could be used in patients with more advanced keratoconus.
[Mh] Termos MeSH primário: Colágeno/uso terapêutico
Reagentes para Ligações Cruzadas/uso terapêutico
Iontoforese/métodos
Ceratocone/terapia
Terapia Ultravioleta/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Córnea/patologia
Feminino
Seres Humanos
Ceratocone/patologia
Masculino
Fármacos Fotossensibilizantes/uso terapêutico
Estudos Retrospectivos
Riboflavina/uso terapêutico
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cross-Linking Reagents); 0 (Photosensitizing Agents); 9007-34-5 (Collagen); TLM2976OFR (Riboflavin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008758


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[PMID]:29284455
[Au] Autor:Lee H; Kang DSY; Ha BJ; Choi JY; Kim EK; Seo KY; Kim TI
[Ad] Endereço:Department of Ophthalmology, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, South Korea.
[Ti] Título:Visual rehabilitation in moderate keratoconus: combined corneal wavefront-guided transepithelial photorefractive keratectomy and high-fluence accelerated corneal collagen cross-linking after intracorneal ring segment implantation.
[So] Source:BMC Ophthalmol;17(1):270, 2017 Dec 29.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To investigate the effects of combined corneal wavefront-guided transepithelial photorefractive keratectomy (tPRK) and accelerated corneal collagen cross-linking (CXL) after intracorneal ring segment (ICRS) implantation in patients with moderate keratoconus. METHODS: Medical records of 23 eyes of 23 patients undergoing combined tPRK and CXL after ICRS implantation were retrospectively analyzed. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), manifest refraction spherical equivalent (MRSE), corneal indices based on Scheimpflug tomography, higher-order aberrations (HOAs), and corneal biomechanical properties were evaluated before and after ICRS implantation, and at 1, 3, and 6 months after combined tPRK and CXL. RESULTS: There were significant improvements in final logMAR UDVA and logMAR CDVA, and reductions in sphere, MRSE, and all corneal indices from baseline. Significant improvements in logMAR UDVA and reductions in sphere, MRSE, maximal keratometry, keratometry at the apex, mean keratometry, and keratoconus index were noted after ICRS implantation. After tPRK and CXL, significant improvements in logMAR UDVA and logMAR CDVA, and reductions in cylinder and all corneal indices were observed. There were significant improvements in final root mean square HOAs and coma aberrations from baseline, but no changes from baseline after ICRS implantation. Significant reductions in final radius and deformation amplitude from baseline were noted. CONCLUSIONS: Combined tPRK and accelerated CXL after ICRS implantation in moderate keratoconus appears to be a safe and effective treatment, providing an improvement in visual acuity, corneal indices, and HOAs. TRIAL REGISTRATION: retrospectively registered (identification no. NCT03355430 ). Date registered: 28/11/2017.
[Mh] Termos MeSH primário: Colágeno/uso terapêutico
Reagentes para Ligações Cruzadas/uso terapêutico
Ceratocone/terapia
Lentes Intraoculares
Fotoquimioterapia/métodos
Ceratectomia Fotorrefrativa/métodos
Acuidade Visual
[Mh] Termos MeSH secundário: Adulto
Substância Própria/patologia
Substância Própria/cirurgia
Topografia da Córnea
Feminino
Seguimentos
Seres Humanos
Ceratocone/diagnóstico
Ceratocone/fisiopatologia
Masculino
Implante de Prótese/métodos
Refração Ocular/fisiologia
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cross-Linking Reagents); 9007-34-5 (Collagen)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171230
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-017-0666-1



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