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[PMID]: 28671927 [Au] Autor: Emanuel ME; Grover DS; Fellman RL; Godfrey DG; Smith O; Butler MR; Kornmann HL; Feuer WJ; Goyal S [Ad] Endereço: *Glaucoma Associates of Texas, Dallas, TX †Miller School of Medicine, Bascom Palmer Eye Institute, University of Miami, Miami, FL. [Ti] Título: Micropulse Cyclophotocoagulation: Initial Results in Refractory Glaucoma. [So] Source: J Glaucoma;26(8):726-729, 2017 Aug. [Is] ISSN: 1536-481X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: PURPOSE: The purpose of this study is to evaluate the use of micropulse transscleral cyclophotocoagulation (MP-TSCPC), a new and increasingly popular treatment, in patients with uncontrolled glaucoma. METHODS: A retrospective chart review was performed for all patients who underwent a MP-TSCPC at the Glaucoma Associates of Texas. RESULTS: A total of 84 eyes were treated with MP-TSCPC in this study with a mean follow-up time of 4.3 months. The mean age of treated patients was 74 years and 48 (57%) were female. Preoperatively, mean intraocular pressure (IOP) was 27.7 mm Hg and mean number of ocular antihypertensive medications used was 3.3. Mean postoperative IOP at months 1, 3, 6, and 12 were lowered to 16.3 mm Hg (41.2% reduction), 14.6, 13.0, and 11.1 mm Hg, respectively. Postoperative ocular antihypertensive medication use was also lowered to 1.9, 2.0, 2.0, and 2.3 medications at months 1, 3, 6, and 12, respectively. Five patients required further laser or surgical intervention for adequate IOP control. Complications included hypotony, IOP spike, hyphema, serous choroidal detachment, persistent inflammation, and vision loss. At 3 months, inflammation was still present in 46% of eyes and vision loss of at least 1 line was present in 41% of eyes. CONCLUSIONS: MP-TSCPC is effective at lowering IOP and decreasing the need for ocular antihypertensive medications. Eyes with limited visual potential or at high risk for incisional glaucoma surgery can successfully be treated with MP-TSCPC as a reasonable and effective alternative to traditional CPC. These results present short-term data and both longer follow-up and further studies are necessary. [Mh] Termos MeSH primário: Corpo Ciliar/cirurgia Glaucoma de Ângulo Aberto/cirurgia Fotocoagulação a Laser/métodos [Mh] Termos MeSH secundário: Adolescente Adulto Idoso Idoso de 80 Anos ou mais Cegueira/etiologia Doenças da Coroide/etiologia Corpo Ciliar/fisiopatologia Feminino Seguimentos Glaucoma de Ângulo Aberto/fisiopatologia Seres Humanos Hifema/etiologia Pressão Intraocular/fisiologia Fotocoagulação a Laser/efeitos adversos Lasers Semicondutores/uso terapêutico Luz Masculino Meia-Idade Oftalmologia Período Pós-Operatório Estudos Retrospectivos Tonometria Ocular Resultado do Tratamento Acuidade Visual/fisiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171106 [Lr] Data última revisão: 171106 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170704 [St] Status: MEDLINE [do] DOI: 10.1097/IJG.0000000000000715

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[PMID]: 28619012 [Au] Autor: Hosogai M; Nakatani Y; Mimura K; Kishi S; Akiyama H [Ad] Endereço: Department of Ophthalmology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan. mayu64jun@gmail.com. [Ti] Título: Genetic analysis of varicella-zoster virus in the aqueous humor in uveitis with severe hyphema. [So] Source: BMC Infect Dis;17(1):427, 2017 Jun 15. [Is] ISSN: 1471-2334 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Genetic variations have been identified in the genome of varicella-zoster virus (VZV) strains using vesicle fluid, varicella scabs and throat swab samples. We report a rare case of VZV-associated uveitis with severe hyphema, which was immediately diagnosed by polymerase chain reaction (PCR) using the aqueous humor, in which we were able to analyze the VZV genotype for the first time. CASE PRESENTATION: A 16-year-old Japanese boy was referred to our hospital with a 20-day history of unilateral anterior uveitis and 11-day history of hyphema. At presentation, details of the iris, the iridocorneal angle, and the fundus were not visible due to the severe hyphema. Serum anti-VZV IgG and anti-VZV IgM were elevated, and 1.61 × 10 copies/mL of VZV-DNA were detected by real-time PCR using the aqueous humor. As there were no eruptions on his face or body, we diagnosed zoster sine herpete and started intravenous administration of prednisolone and acyclovir. The hyphema completely disappeared 2 weeks after presentation, while sectorial iris atrophy and mild periphlebitis of the fundus became gradually apparent. Anterior inflammation and periphlebitis gradually improved and VZV-DNA in the aqueous humor was reduced to 1.02 × 10 copies/mL at 4 weeks after presentation. Examination by slit lamp microscope revealed no inflammation after 5 months, and VZV-DNA could no longer be detected in the aqueous humor. Serum anti-VZV IgG and anti-VZV IgM also showed a gradual decrease along with improvement in ocular inflammation. The genetic analysis of multiple open reading frames and the R5 variable repeat region in the VZV genes, using DNA extracted from the aqueous humor at presentation, showed that the isolate was a wild-type clade 2 VZV strain (prevalent in Japan and surrounding countries) with R5A allele and one SNP unique to clade 1 (both are major types in Europe and North America). CONCLUSIONS: VZV-associated uveitis may develop hyphema that obscures ocular inflammation, thus PCR analysis using the aqueous humor is the key investigation necessary for the diagnosis. The measurement of VZV-DNA copies by real-time PCR would be useful for evaluation of therapeutic effects. We could amplify and analyze VZV genotype using the aqueous humor including a very large number of VZV-DNA copies (1.61 × 10 copies/mL). [Mh] Termos MeSH primário: Humor Aquoso/virologia Herpes Zoster Oftálmico/complicações Herpesvirus Humano 3/genética Hifema/virologia Uveíte Anterior/virologia [Mh] Termos MeSH secundário: Aciclovir/uso terapêutico Adolescente Anticorpos Anti-Idiotípicos/sangue DNA Viral/análise Europa (Continente) Genótipo Herpes Zoster Oftálmico/diagnóstico Herpes Zoster Oftálmico/tratamento farmacológico Herpesvirus Humano 3/isolamento & purificação Herpesvirus Humano 3/patogenicidade Seres Humanos Japão Masculino Reação em Cadeia da Polimerase Uveíte Anterior/tratamento farmacológico [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antibodies, Anti-Idiotypic); 0 (DNA, Viral); 0 (anti-IgM); X4HES1O11F (Acyclovir) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171002 [Lr] Data última revisão: 171002 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170617 [St] Status: MEDLINE [do] DOI: 10.1186/s12879-017-2518-2

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[PMID]: 26806665 [Au] Autor: Krohn J; Tvenning AO; Kjersem B; Høvding G [Ad] Endereço: Department of Clinical Medicine, Section of Ophthalmology, University of Bergen, Bergen, Norway. [Ti] Título: Iris cavernous haemangioma associated with recurrent hyphaema treated by laser photocoagulation. [So] Source: Acta Ophthalmol;95(1):e80-e81, 2017 Feb. [Is] ISSN: 1755-3768 [Cp] País de publicação: England [La] Idioma: eng [Mh] Termos MeSH primário: Hemangioma Cavernoso/cirurgia Hifema/cirurgia Neoplasias da Íris/cirurgia Fotocoagulação a Laser [Mh] Termos MeSH secundário: Adulto Feminino Angiofluoresceinografia Hemangioma Cavernoso/diagnóstico Seres Humanos Hifema/diagnóstico Pressão Intraocular Neoplasias da Íris/diagnóstico Recidiva [Pt] Tipo de publicação: CASE REPORTS; LETTER [Em] Mês de entrada: 1702 [Cu] Atualização por classe: 170207 [Lr] Data última revisão: 170207 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160126 [St] Status: MEDLINE [do] DOI: 10.1111/aos.12967

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[PMID]: 28292093 [Au] Autor: Leila S; Ibtissam H; Hafsa E; Abdeljalil M [Ad] Endereço: Ophthalmology Department, Mohamed VI University Hospital, Marrakech, Morroco. [Ti] Título: Extra-ocular retinoblastoma: about 12 cases followed at the Mohamed VI university hospital of Marrakech. [So] Source: Pan Afr Med J;25:131, 2016. [Is] ISSN: 1937-8688 [Cp] País de publicação: Uganda [La] Idioma: eng [Ab] Resumo: Retinoblastoma is the most frequent childhood intraocular tumor. The aim of our study is to evaluate the clinical features and management of extra-ocular retinoblastoma in the Mohamed VI university hospital of Marrakech. Retrospective case series, the patient's records were reviewed for patient and tumor features, ocular management, histopathological findings, and patient survival. Over a period of three years, 35 eyes were diagnosed with retinoblastoma; 12 children (16 eyes) (46%) had extra-ocular retinoblastoma. Mean age was 27 months, 60% were males. Six cases had unilateral tumor, five bilateral and one case of trilateral retinoblastoma. There was no positive family history, proptosis was the mean mode of presentation (41,6%) followed by staphyloma (25%) orbital cellulitis (25%) and hyphema(8,3%). The median lag period was 18 months. On imaging and histopathological analysis, there was extrascleral involvement in 41.6%, involvement of orbital part of optic nerve (75%), of orbital muscles (50%) and eyelids in 16.6%. the surgical treatment included according to the degree of extension enucleation (75%) or exenteration (25%) associated to chemotherapy in all cases and one case of external beam radiation. There were 2 cases of orbital recurrence, one death and no metastases at 30 months follow-up.Orbital retinoblastoma still stands as a tall challenge requiring multi-modal and multi-disciplinary approach. Although the survival has increased over the last few years, lack of access to medical facilities, lack of education about the need for early medical attention and cultural resistance to enucleation continue to contribute to an epidemic of extra ocular disease at diagnosis in the developing world. [Mh] Termos MeSH primário: Exoftalmia/etiologia Neoplasias da Retina/diagnóstico Retinoblastoma/diagnóstico [Mh] Termos MeSH secundário: Pré-Escolar Feminino Seguimentos Hospitais Universitários Seres Humanos Hifema/etiologia Lactente Masculino Marrocos Recidiva Local de Neoplasia Celulite Orbitária/etiologia Neoplasias da Retina/patologia Neoplasias da Retina/terapia Retinoblastoma/patologia Retinoblastoma/terapia Estudos Retrospectivos Fatores de Tempo [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1703 [Cu] Atualização por classe: 170330 [Lr] Data última revisão: 170330 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170316 [St] Status: MEDLINE [do] DOI: 10.11604/pamj.2016.25.131.8599

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[PMID]: 27938973 [Au] Autor: Sandhu S; Arora S; Edwards MC [Ad] Endereço: Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alta. [Ti] Título: A case of delayed-onset recurrent hyphema after iStent surgery. [So] Source: Can J Ophthalmol;51(6):e165-e167, 2016 Dec. [Is] ISSN: 1715-3360 [Cp] País de publicação: England [La] Idioma: eng [Mh] Termos MeSH primário: Implantes para Drenagem de Glaucoma/efeitos adversos Glaucoma/cirurgia Hifema/etiologia Stents [Mh] Termos MeSH secundário: Idoso Câmara Anterior/cirurgia Feminino Gonioscopia Seres Humanos Pressão Intraocular Recidiva [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1703 [Cu] Atualização por classe: 170817 [Lr] Data última revisão: 170817 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161213 [St] Status: MEDLINE

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[PMID]: 27938972 [Au] Autor: Khouri AS; Megalla MM [Ad] Endereço: Rutgers New Jersey Medical School, Newark, N.J. Electronic address: albert.khouri@rutgers.edu. [Ti] Título: Recurrent hyphema following iStent surgery managed by surgical removal. [So] Source: Can J Ophthalmol;51(6):e163-e165, 2016 Dec. [Is] ISSN: 1715-3360 [Cp] País de publicação: England [La] Idioma: eng [Mh] Termos MeSH primário: Câmara Anterior/cirurgia Implantes para Drenagem de Glaucoma/efeitos adversos Hifema/etiologia Hifema/cirurgia Stents [Mh] Termos MeSH secundário: Remoção de Dispositivo Glaucoma/cirurgia Gonioscopia Seres Humanos Pressão Intraocular Masculino Meia-Idade Recidiva [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1703 [Cu] Atualização por classe: 170817 [Lr] Data última revisão: 170817 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161213 [St] Status: MEDLINE

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[PMID]: 27802426 [Au] Autor: Kung YH; Wu TT [Ad] Endereço: Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC. [Ti] Título: Risk Factors of Hyphema following Surgeries for Primary Rhegmatogenous Retinal Detachment. [So] Source: Ophthalmologica;236(3):159-165, 2016. [Is] ISSN: 1423-0267 [Cp] País de publicação: Switzerland [La] Idioma: eng [Ab] Resumo: PURPOSE: This study aimed to evaluate the risk factors for hyphema complicating primary rhegmatogenous retinal detachment (RRD) surgeries and to analyze outcomes. METHODS: In this retrospective comparative study, we included 1,011 consecutive eyes. Two groups were compared according to the occurrence of postoperative hyphema. RESULTS: Postoperative hyphema occurred in 32 eyes (3.17%). High myopia was significantly related to the occurrence of hyphema (odds ratio [OR] 3.396, 95% confidence interval [CI] 1.502-7.675; p = 0.003). Combined scleral buckling and vitrectomy (SB + VT) was associated with a significantly higher incidence of hyphema (OR 21.266, 95% CI 4.855-93.152; p < 0.001). The final anatomical success rate did not differ significantly between the group with and the group without occurrence of hyphema; however, the primary anatomical success rate was worse in the eyes with hyphema. CONCLUSIONS: High myopia and combined SB + VT were risk factors for hyphema after RRD surgeries. The occurrence of hyphema did not affect the final anatomical success rate at 6 months. [Mh] Termos MeSH primário: Hifema/epidemiologia Miopia/complicações Hemorragia Pós-Operatória/epidemiologia Descolamento Retiniano/cirurgia Medição de Risco Recurvamento da Esclera/efeitos adversos Vitrectomia/efeitos adversos [Mh] Termos MeSH secundário: Feminino Seres Humanos Hifema/diagnóstico Hifema/etiologia Incidência Masculino Meia-Idade Hemorragia Pós-Operatória/diagnóstico Hemorragia Pós-Operatória/etiologia Prognóstico Fatores de Risco Taiwan/epidemiologia Acuidade Visual [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Em] Mês de entrada: 1701 [Cu] Atualização por classe: 170131 [Lr] Data última revisão: 170131 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161102 [St] Status: MEDLINE

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[PMID]: 27315386 [Au] Autor: Hausmann JC; Mans C; Gosling A; Miller JL; Chamberlin T; Dunn JR; Miller PE; Sladky KK [Ti] Título: Bilateral Uveitis and Hyphema in a Catalina Macaw (Ara ararauna × Ara macao ) With Multicentric Lymphoma. [So] Source: J Avian Med Surg;30(2):172-8, 2016 Jun. [Is] ISSN: 1082-6742 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: A 20-year-old, female Catalina macaw (Ara ararauna × Ara macao ) was presented with bilateral uveitis and hyphema. The hyphema initially improved with 0.12% prednisolone acetate ophthalmic drops (1 drop OU q4h for 7 days), but the hyphema recurred after the drops were tapered. The bird subsequently developed inappetance, weight loss, regurgitation, and lethargy and was euthanatized 24 days after initial presentation. Necropsy revealed marked splenomegaly and hepatomegaly, with significant mucosal ulcerations of the proventriculus and petechiation associated with both kidneys. Histopathologic examination revealed multicentric lymphoma, with neoplastic cells observed in ocular, splenic, hepatic, renal, proventricular, intestinal, pancreatic, and choanal tissue. Neoplastic lymphocytes effaced the iris, ciliary body, and the choroid of the eyes, and neoplastic lymphocytes were attached to the corneal endothelium and infiltrated the sclera, episclera, and conjunctivae. Immunohistochemical results indicated that the neoplastic lymphocytes were CD3(+) and CD79a(-), which is consistent with T-cell lymphoma. [Mh] Termos MeSH primário: Doenças das Aves/patologia Hifema/veterinária Linfoma/veterinária Psittaciformes Uveíte/veterinária [Mh] Termos MeSH secundário: Animais Feminino Hifema/patologia Linfoma/patologia Uveíte/patologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1609 [Cu] Atualização por classe: 160618 [Lr] Data última revisão: 160618 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160618 [St] Status: MEDLINE [do] DOI: 10.1647/2015-105

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[PMID]: 27079595 [Au] Autor: Read SP; Cavuoto KM [Ad] Endereço: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida. [Ti] Título: Traumatic open globe injury in young pediatric patients: characterization of a novel prognostic score. [So] Source: J AAPOS;20(2):141-4, 2016 Apr. [Is] ISSN: 1528-3933 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Open globe injury is a common cause of monocular blindness in children. Current formulas to predict outcomes of open globe injury often rely heavily on visual acuity and presence of an afferent pupillary defect, examination elements that are difficult to assess in young children. We aimed to analyze the features of open globe injuries in children aged 0-6 years to facilitate development of a novel algorithm for predicting visual outcomes in this age group. METHODS: The medical records of patients 0-6 years of age presenting at a single institution with open globe injury from 2000 to 2013 were retrospectively reviewed. Epidemiology, physical examination, and intervention data were used to develop a prognostic algorithm. RESULTS: A total of 28 patients were included. Mean age at presentation was 4.2 years (range, 1.9-6.7). Glass was the most common mechanism of injury. Associated findings included uveal prolapse (93%), choroidal detachment (39%), hyphema (32%), and retinal detachment (11%). In addition to primary repair, 43% patients required a lensectomy, and 7% underwent surgery to repair retinal detachment. Complicating cataract (P < 0.005) and a wound >6 mm (P < 0.05) were associated with a final visual acuity worse than 20/40. A novel algorithm for predicting visual outcome was devised with a sensitivity of 81% and a specificity of 92%. CONCLUSIONS: Patients 0-6 years of age with open globe injuries present unique risk factors for poor outcome. The trauma score generated by our algorithm is not reliant on presenting visual acuity and may be useful in predicting prognosis in very young children. [Mh] Termos MeSH primário: Ferimentos Oculares Penetrantes/classificação Ferimentos Oculares Penetrantes/diagnóstico Escala de Gravidade do Ferimento Acuidade Visual/fisiologia [Mh] Termos MeSH secundário: Algoritmos Criança Pré-Escolar Doenças da Coroide/diagnóstico Doenças da Coroide/fisiopatologia Doenças da Coroide/cirurgia Ferimentos Oculares Penetrantes/fisiopatologia Ferimentos Oculares Penetrantes/cirurgia Feminino Seres Humanos Hifema/diagnóstico Hifema/fisiopatologia Hifema/cirurgia Lactente Recém-Nascido Masculino Prognóstico Prolapso Descolamento Retiniano/diagnóstico Descolamento Retiniano/fisiopatologia Descolamento Retiniano/cirurgia Estudos Retrospectivos Medição de Risco Doenças da Úvea/diagnóstico Doenças da Úvea/fisiopatologia Doenças da Úvea/cirurgia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1610 [Cu] Atualização por classe: 161230 [Lr] Data última revisão: 161230 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160416 [St] Status: MEDLINE

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[PMID]: 26907818 [Au] Autor: Goetz RK; Cosgrave E [Ad] Endereço: Department of Ophthalmology, University Hospital Waterford, Dublin, Ireland Department of Ophthalmology, University Hospital Waterford, Waterford, Ireland. [Ti] Título: Spontaneous hyphaemas requiring a closer look. [So] Source: BMJ Case Rep;2016, 2016 Feb 23. [Is] ISSN: 1757-790X [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: We present four cases of acute blurred vision that presented to the Ophthalmology Emergency Department of University Hospital Waterford. All four patients were found to have a spontaneous hyphaema with neither neovascular cause nor traumatic history. The pathophysiology was initially uncertain. On closer investigation, these patients were found to have rare iris microhaemangiomas (IMs) or Cobb's haemangiomas. They were all treated conservatively and made full recoveries. Though some reports recommend treating IM prior to intraocular surgery, one of these patients proceeded to have uncomplicated cataract surgery at a later date with no need for prior intervention. [Mh] Termos MeSH primário: Hemangioma/complicações Hifema/etiologia Iris/patologia Transtornos da Visão/etiologia [Mh] Termos MeSH secundário: Idoso Feminino Hemangioma/terapia Seres Humanos Hifema/terapia Meia-Idade [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1611 [Cu] Atualização por classe: 161230 [Lr] Data última revisão: 161230 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160225 [St] Status: MEDLINE

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