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[PMID]:27772648
[Au] Autor:Nesper PL; Simjanoski E; Mirza RG
[Ad] Endereço:Department of Ophthalmology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
[Ti] Título:Retinal Macroaneurysm in Long-Standing Hypertension.
[So] Source:Ophthalmology;123(11):2327, 2016 11.
[Is] ISSN:1549-4713
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Aneurisma/etiologia
Hipertensão/complicações
Artéria Retiniana/patologia
Doenças Retinianas/etiologia
[Mh] Termos MeSH secundário: Idoso
Aneurisma/diagnóstico por imagem
Arteríolas/diagnóstico por imagem
Arteríolas/patologia
Feminino
Angiofluoresceinografia
Seres Humanos
Artéria Retiniana/diagnóstico por imagem
Doenças Retinianas/diagnóstico por imagem
Hemorragia Retiniana/diagnóstico
Líquido Sub-Retiniano
Tomografia de Coerência Óptica
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29443727
[Au] Autor:Lyu S; Zhang M; Gao Y
[Ad] Endereço:Department of Ophthalmology, West China Hospital of Sichuan University, Wuhou, Chengdu, Sichuan, China.
[Ti] Título:Acute bilateral retina hemorrhages beneath internal limiting membrane: An unusual ophthalmological case report of acute leukemia during complete clinical remission.
[So] Source:Medicine (Baltimore);97(7):e0000, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Leukemia is a common hematologic disease that causes various systemic complications, such as ophthalmological disorders. The venous congestion is considered to be the main clinical sign that occurs during the initial stage of the disease, whereas white-centered hemorrhages are the most typical manifestations in leukemic retinopathy. These complications usually manifest when the disease presents with clinical and hematological symptoms. In the present study, we report a patient who was diagnosed with leukemic retinopathy. The initial signs of this disease were bilateral hemorrhages that occurred during complete clinical remission. Previous studies regarding this condition are quite rare. PATIENT CONCERNS: We report a 26-year-old man who was diagnosed with leukemic retinopathy and exhibited the initial signs of the disease, namely bilateral hemorrhages with a distinct appearance beneath the internal limiting membrane. In addition, flame-shaped hemorrhages were observed surrounding the optic discs and/or along the vessels in the absence of venous congestion. All these changes were present during complete clinical remission. DIAGNOSES: Bilateral acute leukemic retinopathy, acute lymphoblastic leukemia (pro-B lymphocyte, BCR-ABL chimeric gene-positive). INTERVENTIONS: Clinical remission was achieved following effective systemic chemotherapy that was applied for leukemia in the hematology department. A dynamic observation was applied actively in the absence of surgery and/or medical treatment for ophthalmologic treatment. OUTCOMES: Best corrected visual acuity was 20/40 in the right eye and 20/60 in the left eye, which was considerably better than those noted at the initial visit of the patient (20/250 in the right eye and 20/400 in the left eye). LESSONS: The cautious expectant treatment is safe and helpful for acute leukemic retinopathy. A long-term follow-up is inevitable. Effective systemic chemotherapy that is required for leukemia treatment can achieve clinical remission, which might be helpful in controlling the pathological changes of the eyes.
[Mh] Termos MeSH primário: Síndromes Paraneoplásicas Oculares/complicações
Leucemia-Linfoma Linfoblástico de Células Precursoras/complicações
Hemorragia Retiniana/etiologia
[Mh] Termos MeSH secundário: Doença Aguda
Adulto
Seres Humanos
Masculino
Retina/patologia
Hemorragia Retiniana/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000010000


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[PMID]:27770590
[Au] Autor:Cho YH; Craig ME; Januszewski AS; Benitez-Aguirre P; Hing S; Jenkins AJ; Donaghue KC
[Ad] Endereço:Institute of Endocrinology and Diabetes, Children's Hospital at Westmead, Westmead, Australia.
[Ti] Título:Higher skin autofluorescence in young people with Type 1 diabetes and microvascular complications.
[So] Source:Diabet Med;34(4):543-550, 2017 Apr.
[Is] ISSN:1464-5491
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIM: To test the hypothesis that non-invasive skin autofluorescence, a measure of advanced glycation end products, would provide a surrogate measure of long-term glycaemia and be associated with early markers of microvascular complications in adolescents with Type 1 diabetes. METHODS: Forearm skin autofluorescence (arbitrary units) was measured in a cross-sectional study of 135 adolescents with Type 1 diabetes [mean ± sd age 15.6 ± 2.1 years, diabetes duration 8.7 ± 3.5 years, HbA 72 ± 16 mmol/mol (8.7 ± 1.5%)]. Retinopathy, assessed using seven-field stereoscopic fundal photography, was defined as ≥1 microaneurysm or haemorrhage. Cardiac autonomic function was measured by standard deviation of consecutive RR intervals on a 10-min continuous electrocardiogram recording, as a measure of heart rate variability. RESULTS: Skin autofluorescence was significantly associated with age (R = 0.15; P < 0.001). Age- and gender-adjusted skin autofluorescence was associated with concurrent HbA (R = 0.32; P < 0.001) and HbA over the previous 2.5-10 years (R = 0.34-0.43; P < 0.002). Age- and gender-adjusted mean skin autofluorescence was higher in adolescents with retinopathy vs those without retinopathy [mean 1.38 (95% CI 1.29, 1.48) vs 1.22 (95% CI 1.17, 1.26) arbitrary units; P = 0.002]. In multivariable analysis, retinopathy was significantly associated with skin autofluorescence, adjusted for duration (R = 0.19; P = 0.03). Cardiac autonomic dysfunction was also independently associated with skin autofluorescence (R = 0.11; P = 0.006). CONCLUSIONS: Higher skin autofluorescence is associated with retinopathy and cardiac autonomic dysfunction in adolescents with Type 1 diabetes. The relationship between skin autofluorescence and previous glycaemia may provide insight into metabolic memory. Longitudinal studies will determine the utility of skin autofluorescence as a non-invasive screening tool to predict future microvascular complications.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 1/fisiopatologia
Angiopatias Diabéticas/diagnóstico por imagem
Retinopatia Diabética/diagnóstico por imagem
Microaneurisma/diagnóstico por imagem
Hemorragia Retiniana/diagnóstico por imagem
Pele/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adolescente
Doenças do Sistema Nervoso Autônomo/etiologia
Doenças do Sistema Nervoso Autônomo/fisiopatologia
Diabetes Mellitus Tipo 1/complicações
Diabetes Mellitus Tipo 1/metabolismo
Angiopatias Diabéticas/etiologia
Angiopatias Diabéticas/fisiopatologia
Retinopatia Diabética/etiologia
Retinopatia Diabética/fisiopatologia
Eletrocardiografia
Feminino
Fundo de Olho
Hemoglobina A Glicada/metabolismo
Frequência Cardíaca
Seres Humanos
Masculino
Microaneurisma/etiologia
Microaneurisma/fisiopatologia
Análise Multivariada
Imagem Óptica
Hemorragia Retiniana/etiologia
Hemorragia Retiniana/fisiopatologia
Pele/irrigação sanguínea
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycated Hemoglobin A); 0 (hemoglobin A1c protein, human)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE
[do] DOI:10.1111/dme.13280


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[PMID]:29188462
[Au] Autor:Kim JH; Chang YS; Lee DW; Kim CG; Kim JW
[Ad] Endereço:Department of Ophthalmology, Kim's Eye Hospital, Konyang University College of Medicine, #156 Youngdeungpo-dong 4ga, Youngdeungpo-gu, Seoul, 150-034, South Korea. kimoph@gmail.com.
[Ti] Título:Quantification of retinal changes after resolution of submacular hemorrhage secondary to polypoidal choroidal vasculopathy.
[So] Source:Jpn J Ophthalmol;62(1):54-62, 2018 Jan.
[Is] ISSN:1613-2246
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To evaluate changes in the thickness of retinal layers after resolution of submacular hemorrhage secondary to polypoidal choroidal vasculopathy (PCV). STUDY DESIGN: Retrospective, observational study. METHODS: This study included 21 patients (21 eyes) who had been diagnosed with submacular hemorrhage secondary to PCV and treated using anti-vascular endothelial growth factor monotherapy. After the hemorrhage had resolved, the thicknesses of the retinal layers were measured on horizontal- and vertical-crosshair optical coherence tomography scan images. The thickness of each layer in the region affected by the hemorrhage was compared with the thickness of the layer in the corresponding region in the fellow eye, as well as between an unaffected region in the eye with the hemorrhage and the corresponding region in the fellow eye. RESULTS: Optical coherence tomography (OCT) was performed 5.5±2.8 months after diagnosis. In the horizontal OCT images, the outer plexiform layer (OPL) and outer nuclear layer (ONL) + photoreceptor layer (PRL) were significantly thinner in the affected region than in the corresponding region (P = 0.019 and P <0.001, respectively). In the vertical OCT image, the ONL+PRL was significantly thinner in the affected region than in the corresponding region (P <0.001). The thickness of the retinal layer in the unaffected region did not differ from that in the corresponding region of the fellow eye. CONCLUSIONS: The significant thinning of the outer retinal layers in the regions affected by submacular hemorrhage suggests that the hemorrhage induces marked damage in the outer retinal layers, explaining the poor visual prognosis of submacular hemorrhage.
[Mh] Termos MeSH primário: Neovascularização de Coroide/fisiopatologia
Pólipos/fisiopatologia
Hemorragia Retiniana/fisiopatologia
Neurônios Retinianos/patologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Inibidores da Angiogênese/uso terapêutico
Neovascularização de Coroide/complicações
Neovascularização de Coroide/tratamento farmacológico
Corantes/administração & dosagem
Feminino
Angiofluoresceinografia
Seres Humanos
Verde de Indocianina/administração & dosagem
Injeções Intravítreas
Masculino
Meia-Idade
Pólipos/complicações
Pólipos/tratamento farmacológico
Ranibizumab/uso terapêutico
Receptores de Fatores de Crescimento do Endotélio Vascular/uso terapêutico
Proteínas Recombinantes de Fusão/uso terapêutico
Hemorragia Retiniana/tratamento farmacológico
Hemorragia Retiniana/etiologia
Estudos Retrospectivos
Tomografia de Coerência Óptica
Fator A de Crescimento do Endotélio Vascular/antagonistas & inibidores
Acuidade Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Angiogenesis Inhibitors); 0 (Coloring Agents); 0 (Recombinant Fusion Proteins); 0 (VEGFA protein, human); 0 (Vascular Endothelial Growth Factor A); 15C2VL427D (aflibercept); EC 2.7.10.1 (Receptors, Vascular Endothelial Growth Factor); IX6J1063HV (Indocyanine Green); ZL1R02VT79 (Ranibizumab)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1007/s10384-017-0549-2


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[PMID]:29253013
[Au] Autor:Ha A; Kim YK; Jeoung JW; Park KH
[Ad] Endereço:Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
[Ti] Título:Impact of optic disc hemorrhage on subsequent glaucoma progression in mild-to-moderate myopia.
[So] Source:PLoS One;12(12):e0189706, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To investigate optic disc hemorrhage (DH)'s clinical implications to subsequent progression of primary open-angle glaucoma (POAG) in cases of mild-to-moderate myopia. DESIGN: Retrospective comparative study. PARTICIPANTS: (1) Fifty-nine (59) myopic (26.5 mm > axial length [AXL] ≥ 24.0 mm) POAG patients with DH and (2) 59 age-, AXL-, and mean deviation (MD) of visual field (VF)-matched controls without DH were evaluated over the course of a minimum 3.5 years of follow up. For clear assessment of the effect of DH on progression of glaucoma, the patients selected for inclusion in the study were those with stable IOP (i.e., those showing an at least 20% reduction relative to the baseline IOP) whose IOP-lowering medication was not increased, supplemented or changed during the follow-up period. METHODS: The patients' optic disc/retinal nerve fiber layer (RNFL) photographs were independently evaluated by three glaucoma specialists for structural progression of glaucoma. Event-based analysis with Guided Progression Analysis (GPA) software was used to determine their functional progression. The durations of structural and functional progression were compared by Kaplan-Meier life survival analyses. MAIN OUTCOME MEASURES: Optic disc/RNFL progression and VF progression. RESULTS: The mean follow-up periods between the DH and non-DH groups were not significantly different: in the DH group, 5.6±2.7 years; in the non-DH group, 5.4±2.6 years (P = 0.588). In the DH group, 30 (50.8%) of 59 eyes manifested optic disc/RNFL deterioration; in the non-DH group, however, only 17 (28.8%) of 59 eyes showed structural progression. For the DH group, the cumulative probability of structural glaucoma progression was significantly greater than for the non-DH group (P = 0.001; log rank test). Interestingly, the two groups did not significantly differ in the cumulative probability of functional progression (P = 0.79; log rank test): in the DH group, VF progression was observed in 14 eyes (23.7%); in the non-DH group, in 12 eyes (20.3%). CONCLUSIONS: DH was associated with a greater probability of structural progression in medically well-controlled-IOP POAG eyes with mild-to-moderate myopia. However, the relevance of DH to VF progression was not clear over the course of the average 5.5-year duration of the study.
[Mh] Termos MeSH primário: Glaucoma de Ângulo Aberto/patologia
Miopia/patologia
Hemorragia Retiniana/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Progressão da Doença
Feminino
Seguimentos
Glaucoma de Ângulo Aberto/complicações
Seres Humanos
Estimativa de Kaplan-Meier
Masculino
Meia-Idade
Miopia/complicações
Disco Óptico/fisiopatologia
Hemorragia Retiniana/complicações
Estudos Retrospectivos
Fatores de Risco
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189706


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[PMID]:29258454
[Au] Autor:Lee JY; Kim DY; Lee HJ; Jeong JH; Park SP; Kim JY
[Ad] Endereço:Department of Ophthalmology, Jeju National University Hospital, Jeju National University School of Medicine, 1753-3 Ara-1 Dong, Jeju-Si, Jeju Self-Governing Province, Republic of Korea.
[Ti] Título:Atypical acute retinal necrosis accompanied by Terson's syndrome: a case report.
[So] Source:BMC Ophthalmol;17(1):255, 2017 Dec 19.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Acute retinal necrosis (ARN) has characterized by panuveitis, vitritis, severe vaso-occlusive vasculitis, and diffuse necrotizing retinitis. There are no case reports on atypical ARN combined with Terson's syndrome. Herein, we report a case of ARN with atypical clinical features combined with Terson's syndrome that we successfully treated by intravitreal ganciclovir injection. CASE PRESENTATION: A 64-year-old man visited our eye clinic with a complaint of decreased visual acuity in his right eye. At the initial visit, his best corrected visual acuity was 20/125 in the right eye. Slit-lamp examination demonstrated mild hyperemia, keratic precipitates, and anterior chamber inflammatory reaction. Fundus examination revealed multiple diffuse white-yellowish infiltrations in the peripheral retina combined with dot hemorrhages. Ultra-wide-field fluorescence angiography showed obstructive arteritis with peripheral non-perfusion and leakage from the retinal vessels. As a result of the PCR analysis, varicella zoster virus DNA was identified in the aqueous humor. Under the diagnosis with VZV-mediated ARN, we started with intravenous acyclovir and oral prednisolone. After 3 days of the above treatment, the anterior chamber inflammation and vitreous opacity were increased. On fundus examination, multiple whitish infiltrations were increased. In addition, newly developed vitreous and peripapillary hemorrhages were detected. On the T2 brain magnetic resonance imaging (MRI) demonstrated a sub-acute or old hemorrhagic infarction in the right occipital lobe, and contrast-enhancing lesions in the right basal ganglia. The spinal tapping was performed in the department of neurology in our hospital at the time when the patient complained of headache, and intracranial pressure was 31 mmHg. Under the diagnosis of ARN with Terson's syndrome, we started intravitreal ganciclovir (2 mg/0.5 ml) injections. After 5 intravitreal ganciclovir injections over a period of 8 months, the diffuse whitish infiltrating retinal lesions combined with dot hemorrhage were decreased. The vitreous and peripapillary hemorrhage was significantly reduced. There was no recurrence in the patient's right eye, in which his visual acuity had improved to 20/60. CONCLUSIONS: In the event of a poor response to traditional treatment such as intravenous acyclovir, intravitreal ganciclovir may have a role as an adjunctive therapy in patients of VZV associated ARN combined with Terson's syndrome.
[Mh] Termos MeSH primário: Hemorragias Intracranianas/complicações
Síndrome de Necrose Retiniana Aguda/patologia
Hemorragia Vítrea/patologia
[Mh] Termos MeSH secundário: Seres Humanos
Masculino
Meia-Idade
Hemorragia Retiniana/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-017-0655-4


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[PMID]:29261845
[Au] Autor:Lee WJ; Kim YK; Park KH; Jeoung JW
[Ad] Endereço:Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
[Ti] Título:Evaluation of Ganglion Cell-Inner Plexiform Layer Thinning in Eyes With Optic Disc Hemorrhage: A Trend-Based Progression Analysis.
[So] Source:Invest Ophthalmol Vis Sci;58(14):6449-6456, 2017 Dec 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To evaluate the rate of change in ganglion cell-inner plexiform layer (GCIPL) thickness measured by optical coherence tomography (OCT) using a trend-based approach in early-stage glaucomatous eyes with disc hemorrhage (DH) and to compare the GCIPL thinning rate with that in glaucomatous eyes without DH. Methods: This prospective observational study included 46 patients with early-stage open-angle glaucoma and DH who underwent serial spectral-domain OCT measurements for at least 30 months. The GCIPL thinning rate was determined in the global, superior, or inferior hemiretinas and in six macular sectors by linear regression and was compared between glaucomatous eyes with DH and fellow glaucomatous eyes without DH and between glaucomatous eyes with DH and non-DH glaucomatous control eyes. Results: The GCIPL thinning rate (mean ± standard deviation) was significantly more rapid in glaucomatous eyes with DH than in fellow eyes without DH in the inferior hemiretina (-1.07 ± 0.75 vs. -0.44 ± 0.54 µm/y, P = 0.001), inferotemporal sector (-1.13 ± 1.00 vs. -0.61 ± 0.66 µm/y, P = 0.028), and inferior sector (-1.33 ± 0.79 vs. -0.42 ± 0.78 µm/y, P < 0.001). The GCIPL thinning rate was significantly more rapid in glaucomatous eyes with DH than in glaucomatous controls without DH in the global area (-0.78 ± 0.85 vs. -0.32 ± 0.48 µm/y, P = 0.002), the inferior hemiretina (-1.00 ± 0.94 vs. -0.37 ± 0.67 µm/y, P < 0.001), and the inferotemporal sector (-1.31 ± 1.07 vs. -0.34 ± 0.75 µm/y, P < 0.001). Conclusions: The GCIPL thinning rate on OCT was significantly more rapid in glaucomatous eyes with DH than in fellow glaucomatous eyes without DH or glaucomatous control eyes without DH. DH could be associated with progression of glaucoma in terms of GCIPL thinning.
[Mh] Termos MeSH primário: Glaucoma de Ângulo Aberto/diagnóstico
Disco Óptico/irrigação sanguínea
Doenças do Nervo Óptico/diagnóstico
Hemorragia Retiniana/diagnóstico
Segmento Interno das Células Fotorreceptoras da Retina/patologia
Tomografia de Coerência Óptica/métodos
[Mh] Termos MeSH secundário: Progressão da Doença
Seguimentos
Glaucoma de Ângulo Aberto/fisiopatologia
Seres Humanos
Pressão Intraocular
Fibras Nervosas/patologia
Disco Óptico/patologia
Doenças do Nervo Óptico/etiologia
Estudos Prospectivos
Hemorragia Retiniana/etiologia
Acuidade Visual
Campos Visuais
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22547


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[PMID]:29217027
[Au] Autor:Ozturker ZK; Munro K; Gupta N
[Ad] Endereço:Glaucoma Unit, University of Toronto, Toronto, Ont.; Ophthalmology & Vision Sciences, University of Toronto, Toronto, Ont.
[Ti] Título:Optic disc hemorrhages in glaucoma and common clinical features.
[So] Source:Can J Ophthalmol;52(6):583-591, 2017 Dec.
[Is] ISSN:1715-3360
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To analyze optic nerve head stereophotographs for the presence of optic disc hemorrhages, and to describe bleeding patterns and patient characteristics. DESIGN: Retrospective, cross-sectional study. PARTICIPANTS: 1113 optic nerve stereophotograph pairs of 562 consecutive patients. METHODS: Stereophotographs were systematically reviewed for the presence of a disc hemorrhage with careful documentation of optic nerve head features. All charts of patients with hemorrhage were subsequently studied for demographic information and clinical data. RESULTS: Disc hemorrhages were observed in 7.1% of patients with optic disc photography. Most patients had open-angle glaucoma (57.5%) with focal ischemic phenotype of the optic disc (66.7%). The mean vertical and horizontal cup-disc ratios were 0.82 ± 0.14 and 0.76 ± 0.14, respectively. The ß-zone peripapillary atrophy was observed in 48.9% of patients. The most common location was the inferotemporal region of the disc (60.8%), and most were flame or splinter shaped (70.6%). Disc hemorrhages were found either superficial to or within the retinal nerve fibre layer (72.5%), and in association with a notch (64.4%). The average intraocular pressure was 17.3 ± 4.9 mm Hg, and most hemorrhages were associated with early visual field defects (42.5%). CONCLUSIONS: Optic disc hemorrhages in patients with glaucoma were most frequently observed inferiorly in association with a notch. Most eyes with a disc hemorrhage had an intraocular pressure within normal range and had either early or no visual field loss. These findings highlight the importance of careful examination of the optic nerve head to look for the presence of a disc hemorrhage as an important biomarker of glaucoma damage.
[Mh] Termos MeSH primário: Glaucoma de Ângulo Fechado/diagnóstico
Glaucoma de Ângulo Aberto/diagnóstico
Glaucoma de Baixa Tensão/diagnóstico
Disco Óptico/patologia
Doenças do Nervo Óptico/diagnóstico
Hemorragia Retiniana/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Estudos Transversais
Feminino
Seres Humanos
Pressão Intraocular
Masculino
Meia-Idade
Doenças do Nervo Óptico/classificação
Fotografia
Estudos Retrospectivos
Tonometria Ocular
Campos Visuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE


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[PMID]:29049728
[Au] Autor:Kogachi K; Wolfe JD; Kashani AH
[Ad] Endereço:USC Roski Eye Institute, Keck School of Medicine of USC, Los Angeles, California, United States.
[Ti] Título:Surgically Induced Focal Retinal Detachment Does Not Cause Detectable SD-OCT Retinal Changes in Normal Human Retina.
[So] Source:Invest Ophthalmol Vis Sci;58(12):5270-5279, 2017 Oct 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: Induction of focal retinal detachment (RD) for subretinal delivery of stem cells and gene therapy is increasingly common. In order to determine if this procedure has an adverse impact on the retina, we use spectral-domain optical coherence tomography (SD-OCT) to evaluate the pre- and postoperative retinal anatomy of the incidentally detached normal retina surrounding large submacular hemorrhages (SMH) during surgical displacement procedures. Methods: Retrospective, observational study of human subjects with monocular SMH evaluated before and after surgical displacement using clinical exam, fundus photography, and SD-OCT. Manual measurements of the inner retinal thickness (IRT), outer retinal thickness (ORT), and full retinal thickness (FRT) were made in regions involving the SMH and surrounding normal retina. Comparison of retinal thickness measurements was made using the Wilcoxon signed-rank test. Results: Seven eyes were included in this study. All eyes successfully underwent surgical displacement of SMH. Visual acuity improved in 6/7 subjects and was unchanged in the remaining subject. Incidental RD of the normal retinal regions surrounding the SMH did not cause any significant change in IRT, ORT, or FRT that was detectable by SD-OCT. In contrast, mean FRT overlying regions with SMH was significantly greater before surgery compared to after displacement of SMH or normal adjacent retina. Conclusions: Surgically induced focal RD does not cause detectable retinal changes in the incidentally detached normal retina surrounding large SMH. Therefore, surgical induction of focal RD should not be considered to have the same adverse impact on the retina as pathologic RD.
[Mh] Termos MeSH primário: Retina/patologia
Descolamento Retiniano/cirurgia
Hemorragia Retiniana/cirurgia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Meia-Idade
Retina/diagnóstico por imagem
Descolamento Retiniano/fisiopatologia
Hemorragia Retiniana/fisiopatologia
Estudos Retrospectivos
Tomografia de Coerência Óptica/métodos
Acuidade Visual/fisiologia
Vitrectomia
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; OBSERVATIONAL STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22737


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[PMID]:29049226
[Au] Autor:Tsuchihashi K; Shimokawa H; Takayoshi K; Nio K; Aikawa T; Matsushita Y; Wada I; Arita S; Ariyama H; Kusaba H; Sonoda KH; Akashi K; Baba E
[Ad] Endereço:aDepartment of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University bDepartment of Medical Oncology, National Hospital Organization Kyushu Medical Center cDepartment of Gastrointestinal and Medical Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka dDepartment of Medical Oncology, Sasebo Kyosai Hospital, Sasebo eDepartment of Medical Oncology, Fukuoka Wajiro Hospital fDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka gDepartment of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki hDepartment of Comprehensive Clinical Oncology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
[Ti] Título:Regorafenib-induced retinal and gastrointestinal hemorrhage in a metastatic colorectal cancer patient with liver dysfunction: A case report.
[So] Source:Medicine (Baltimore);96(42):e8285, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Regorafenib is effective for metastatic colorectal cancer but its toxicity such as hemorrhage should be considered. The safety of regorafenib for the patient with the liver disease is not known. PATIENT CONCERNS: Seventy-one-year old man of colon cancer had myodesopsia and blood stool after 14 days from the initiation of regorafenib administration with 50% dose reduction due to liver dysfunction. DIAGNOSES: Fundus examination revealed hemorrhage of the retinal vein. INTERVENTIONS: Regorafenib treatment was discontinued and observational therapy was pursued. OUTCOMES: Retinal and gastrointestinal hemorrhage resolved in 1 week. LESSONS: Retinal hemorrhage should be considered as the differential diagnosis of myodesopsia in the patient treated by regorafenib. Safety and pharmacokinetic of continuous regorafenib administration for patients with liver dysfunction remains to be clarified.
[Mh] Termos MeSH primário: Antineoplásicos/efeitos adversos
Neoplasias Colorretais/tratamento farmacológico
Hemorragia Gastrointestinal/induzido quimicamente
Compostos de Fenilureia/efeitos adversos
Piridinas/efeitos adversos
Hemorragia Retiniana/induzido quimicamente
[Mh] Termos MeSH secundário: Idoso
Antineoplásicos/farmacocinética
Antineoplásicos/uso terapêutico
Neoplasias Colorretais/complicações
Neoplasias Colorretais/patologia
Relação Dose-Resposta a Droga
Seres Humanos
Hepatopatias/complicações
Masculino
Metástase Neoplásica
Compostos de Fenilureia/farmacocinética
Compostos de Fenilureia/uso terapêutico
Piridinas/farmacocinética
Piridinas/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Phenylurea Compounds); 0 (Pyridines); 24T2A1DOYB (regorafenib)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008285



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