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[PMID]:29506497
[Au] Autor:Park SJ; Noh JH; Park KB; Jang SY; Lee JW
[Ad] Endereço:College of medicine, Soonchunhyang University, 204-ho, 31 Soonchunhyang-6-gil, Dongnam-gu, Cheonan, 31151, Choongcheongnam-do, South Korea.
[Ti] Título:A novel surgical technique for punctal stenosis: placement of three interrupted sutures after rectangular three-snip punctoplasty.
[So] Source:BMC Ophthalmol;18(1):70, 2018 Mar 05.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We developed a novel surgical technique to treat punctal stenosis involving the placement of three interrupted sutures after rectangular three-snip punctoplasty (TSP). METHODS: Retrospective chart review of forty-eight eyes of 44 patients who underwent rectangular TSP with three interrupted sutures was performed. We investigated whether anatomical recurrences (re-stenosis) occurred during the follow-up period. The subjective symptoms of patients were surveyed. RESULTS: The mean patient age was 64.1 years, and the mean follow-up time was 17.4 months. The placement of three interrupted sutures after rectangular TSP afforded satisfactory outcomes. Regarding subjective symptoms, 91.7% of the eyes (44/48) were reported as improved. Among 4 eyes determined as symptomatic failure, anatomical recurrence (re-stenosis of the punctum) was observed in only one eye. The other three (6.25%, 3/48 eyes) showed functional nasolacrimal obstruction, namely epiphora with patent tear duct. CONCLUSIONS: Placement of three interrupted sutures after rectangular TSP to treat punctal stenosis showed promising results. Notably anatomical success rate was about 98%. Further comparisons between the novel surgical technique and conventional techniques are required.
[Mh] Termos MeSH primário: Doenças Palpebrais/cirurgia
Aparelho Lacrimal/cirurgia
Obstrução dos Ductos Lacrimais/terapia
Procedimentos Cirúrgicos Oftalmológicos
Técnicas de Sutura
[Mh] Termos MeSH secundário: Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Nylons
Estudos Retrospectivos
Suturas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nylons)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180307
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0733-2


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[PMID]:28746253
[Au] Autor:Schear MJ; Rodgers R
[Ad] Endereço:Hofstra Northwell Health School of Medicine, Department of Ophthalmology, Great Neck and Department of Ophthalmology, Mount Sinai Healthcare System, New York, New York, U.S.A.
[Ti] Título:A Case of Everolimus-Induced Eyelid Edema.
[So] Source:Ophthal Plast Reconstr Surg;34(1):e21-e22, 2018 Jan/Feb.
[Is] ISSN:1537-2677
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Everolimus is a newer generation mammalian target of rapamycin inhibitor approved for immunosuppressive use in a number of advanced medical conditions. The authors report a unique case of persistent eyelid edema believed to be related to the immunosuppressive therapy. The therapy was being well tolerated despite the persistent eyelid edema, so the patient underwent a bilateral upper eyelid blepharoplasty. The patient responded well with resolution of her eyelid dermatochalasis and markedly decreased edema. Everolimus-induced eyelid edema should be recognized by clinicians as a potential side effect of the medication. Surgical excision of excess eyelid tissue by blepharoplasty can be a successful way to manage this side effect.Everolimus (zortress) was initially approved as an immunosuppressive agent for renal transplantation patients. Approval for the treatment of subependymal giant cell astrocytomas associated with tuberous sclerosis, progressive metastatic pancreatic neuroendocrine tumors, human epidermal growth factor receptor 2 negative breast cancer in postmenopausal woman, liver transplantation patients, and well-differentiated neuroendocrine tumors of gastrointestinal or pulmonary origin has followed., Everolimus is a derivative of sirolimus (rapamune), and similar to sirolimus acts as an inhibitor of mammalian target of rapamycin. Few prior studies have reported eyelid edema from sirolomus. Many prior medications have been implicated in eyelid edema formation. To date, periocular edema has not been reported as a side effect of everolimus. We report a patient with bilateral upper eyelid edema associated with everolimus therapy requiring surgical intervention to ameliorate the significant skin redundancy and the visual field defect. This report complies with the Declaration of Helsinki and Health Insurance Portability and Accountability Act regulations.
[Mh] Termos MeSH primário: Edema/induzido quimicamente
Everolimo/efeitos adversos
Doenças Palpebrais/induzido quimicamente
Rejeição de Enxerto/tratamento farmacológico
[Mh] Termos MeSH secundário: Idoso
Blefaroplastia
Edema/diagnóstico
Edema/cirurgia
Everolimo/uso terapêutico
Doenças Palpebrais/diagnóstico
Doenças Palpebrais/cirurgia
Feminino
Transplante de Coração/efeitos adversos
Seres Humanos
Imunossupressores/efeitos adversos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunosuppressive Agents); 9HW64Q8G6G (Everolimus)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1097/IOP.0000000000000974


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[PMID]:28468185
[Au] Autor:Park J; Chang M
[Ad] Endereço:*Nune Eye Hospital, Daegu †Department of Ophthalmology, Dongguk University, Ilsan Hospital, Gyounggi, South Korea.
[Ti] Título:Eyelid Fat Atrophy and Depigmentation After an Intralesional Injection of Triamcinolone Acetonide to Treat Chalazion.
[So] Source:J Craniofac Surg;28(3):e198-e199, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Two patients with depigmentation and fat atrophy after an intralesional injection of triamcinolone acetonide (TA) to treat chalazion are reported. A 2-year-old girl with chalazion in her right lower eyelid received a subconjunctival injection of TA and developed fat atrophy and depigmentation around the injected area. These changes subsided after 7 months. The second patient was a 5-year-old boy who received a triamcinolone injection into a chalazion through the eyelid skin and also developed fat atrophy and depigmentation but these changes improved after 1 year.
[Mh] Termos MeSH primário: Calázio/tratamento farmacológico
Doenças Palpebrais/induzido quimicamente
Pálpebras/patologia
Triancinolona Acetonida/efeitos adversos
[Mh] Termos MeSH secundário: Atrofia/induzido quimicamente
Atrofia/diagnóstico
Calázio/patologia
Pré-Escolar
Doenças Palpebrais/patologia
Pálpebras/efeitos dos fármacos
Feminino
Glucocorticoides/administração & dosagem
Glucocorticoides/efeitos adversos
Seres Humanos
Injeções Intralesionais/efeitos adversos
Masculino
Triancinolona Acetonida/administração & dosagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids); F446C597KA (Triamcinolone Acetonide)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003367


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[PMID]:28224802
[Au] Autor:Písová A; Chovanec M; Betka J; Ferrová K; Ceská Burdová M; Odehnal M; Dotrelová D; Mahelková G
[Ti] Título:[The Tear Osmolarity of PATIENTS with Lagophthalmos].
[Ti] Título:Osmolarita slz u pacientu s lagoftalmem..
[So] Source:Cesk Slov Oftalmol;72(5):172-176, 2016.
[Is] ISSN:1211-9059
[Cp] País de publicação:Czech Republic
[La] Idioma:cze
[Ab] Resumo:INTRODUCTION: Lagophthalmos can be characterized as the dysfunction of the eye aperture and in some cases even by the disruption of tear production. Dry eye syndrome can consequently develop. Instability of the tear film, hyperosmolarity and inflammatory reaction are considered as the key mechanisms of dry eye syndrome. In our report we monitored the tear osmolarity of patients with postsurgical unilateral lagophthalmos. Results were compared with tear osmolarity of the non-lagophthalmic eyes. METHODS: We examined 10 patients (6 women, 4 men) with postsurgical facial nerve palsy and lagophthalmos complicating management of either cerebellopontine (8 patients) or salivary gland tumors (2 patients). Only patients without severe corneal defects enrolled the study. The tear osmolarity was measured in lower tear meniscus by TearLab Osmolarity System device. The lagophthalmic eye was always examined first. The results are presented as mean plus/minus the standard deviation. The paired t-test was used for statistical data processing. The p-value 0,05 was considered as statistically significant. RESULTS: The mean tear osmolarity of the lagophthalmic eyes was 296 ± 15,0 mosmol/l (275-315 mosmol/l). In case of healthy eyes the mean osmolarity was 310 ± 12 mosmol/l (292-336 mosmol/l). The tear osmolarity in case of lagophthalmos was significantly lower than in the healthy eyes (p = 0,05). CONCLUSION: In contrary to the studies demonstrating higher tear osmolarity under the scenario of dry eye syndrome, we found lower tear osmolarity in the lagophthalmic eyes than in the healthy eyes. The possible reason could be the changes in tear dynamics of the lagophthalmic eye due to disturbance of eye lid function. Our results also stress the need of evaluation of the actual tear osmolarity in the view of complex clinical eye findings. The place of tear collection should also be considered.Key words: lagophthalmos, dry eye syndrom, tear osmolarity.
[Mh] Termos MeSH primário: Síndromes do Olho Seco/metabolismo
Doenças Palpebrais/metabolismo
Lágrimas/química
[Mh] Termos MeSH secundário: Adulto
Biometria
Síndromes do Olho Seco/diagnóstico
Doenças Palpebrais/diagnóstico
Feminino
Seres Humanos
Masculino
Meia-Idade
Concentração Osmolar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170223
[St] Status:MEDLINE


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[PMID]:29055358
[Au] Autor:Chhadva P; Goldhardt R; Galor A
[Ad] Endereço:Department of Ophthalmology, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois.
[Ti] Título:Meibomian Gland Disease: The Role of Gland Dysfunction in Dry Eye Disease.
[So] Source:Ophthalmology;124(11S):S20-S26, 2017 Nov.
[Is] ISSN:1549-4713
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:TOPIC: To discuss the pathology, causes, and ocular surface impact of meibomian gland disease (MGD), as well as its relationship to dry eye. CLINICAL RELEVANCE: MGD is a common disorder with various contributing mechanisms and clinical manifestations. Understanding MGD pathophysiology and its relationship to dry eye is important in order to optimize diagnosis and treatment algorithms. METHODS: A review of current literature was performed to discern MGD in terms of pathophysiology, risk factors, and ocular surface impact, and the relationship to dry eye. RESULTS: Meibomian gland obstruction and meibocyte depletion are important components of MGD. Many pathologies can disrupt function of meibomian glands, ranging from congenital to acquired causes. Once gland disruption occurs, the quality and quantity of meibum is altered, with a negative impact on the ocular surface. Increased tear evaporation, tear hyperosmolarity, increased ocular surface staining, increased inflammation, symptomatic irritation of the eyelid and globes, as well as decreased visual acuity have all been observed. CONCLUSION: MGD leads to changes in meibum quality and quantity that can cause evaporative dry eye and ocular surface disruption, leading to dry eye symptoms in some individuals.
[Mh] Termos MeSH primário: Síndromes do Olho Seco/fisiopatologia
Doenças Palpebrais/fisiopatologia
Glândulas Tarsais/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171023
[St] Status:MEDLINE


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[PMID]:28950941
[Au] Autor:Mizoguchi S; Iwanishi H; Arita R; Shirai K; Sumioka T; Kokado M; Jester JV; Saika S
[Ad] Endereço:Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan.
[Ti] Título:Ocular surface inflammation impairs structure and function of meibomian gland.
[So] Source:Exp Eye Res;163:78-84, 2017 Oct.
[Is] ISSN:1096-0007
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Dysfunction of the meibomian glands alters secreted meibum quantitatively and qualitatively that can lead to damage to the ocular surface epithelium. In response to an unstable tear film cause by meibomian gland dysfunction, ocular surface epithelium is damaged and expresses inflammatory cytokines leading to secondary ocular inflammation. In turn, inflammatory disorders of the palpebral conjunctiva and lid margin may affect the structure and function of meibomian gland. The disorders include allergic conjunctivitis, long-term usage of contact lenses, dermatological diseases that affect conjunctival homeostasis, Stevens-Johnson's syndrome or chemical burning of the ocular surface and lid margin.
[Mh] Termos MeSH primário: Doenças da Túnica Conjuntiva/complicações
Epitélio Anterior/metabolismo
Doenças Palpebrais/complicações
Glândulas Tarsais/metabolismo
[Mh] Termos MeSH secundário: Lentes de Contato/efeitos adversos
Edema da Córnea/metabolismo
Citocinas/metabolismo
Seres Humanos
Lágrimas/química
Lágrimas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Cytokines)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE


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[PMID]:28950937
[Au] Autor:Jeyalatha MV; Qu Y; Liu Z; Ou S; He X; Bu J; Li S; Reinach PS; Liu Z; Li W
[Ad] Endereço:Eye Institute of Xiamen University, Xiamen, Fujian, China; Medical College of Xiamen University, Xiamen, Fujian, China; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, Fujian, China.
[Ti] Título:Function of meibomian gland: Contribution of proteins.
[So] Source:Exp Eye Res;163:29-36, 2017 Oct.
[Is] ISSN:1096-0007
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The meibomian gland is the major contributor to the tear film lipid layer. It is generally accepted that meibomian gland secretions, i.e, meibum, play a critical role in the homeostasis of the tear film. Lipid components of meibum and their structure, as well as functions were intensively studied. However, the proteins from meibum have not attracted enough attention. This review summarizes current knowledge about protein components of the meibum, particularly their function on tear film and ocular surface, and changes in the proteins during meibomian gland dysfunction (MGD).
[Mh] Termos MeSH primário: Proteínas do Olho/fisiologia
Glândulas Tarsais/fisiologia
Lágrimas/química
[Mh] Termos MeSH secundário: Proteínas do Olho/metabolismo
Doenças Palpebrais/metabolismo
Doenças Palpebrais/fisiopatologia
Seres Humanos
Glândulas Tarsais/metabolismo
Glândulas Tarsais/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Eye Proteins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE


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[PMID]:28887117
[Au] Autor:Liu R; Rong B; Tu P; Tang Y; Song W; Toyos R; Toyos M; Yan X
[Ad] Endereço:Department of Ophthalmology, Peking University First Hospital, Beijing, China.
[Ti] Título:Analysis of Cytokine Levels in Tears and Clinical Correlations After Intense Pulsed Light Treating Meibomian Gland Dysfunction.
[So] Source:Am J Ophthalmol;183:81-90, 2017 Nov.
[Is] ISSN:1879-1891
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To investigate the change from baseline of inflammatory markers in tears of dry eye disease (DED) subjects owing to meibomian gland dysfunction (MGD) after intense pulsed light (IPL) treatment and meibomian gland expression (MGE) compared to sham treatment, and the correlations with ocular surface parameters. DESIGN: Randomized, double-masked, controlled study. METHODS: Those randomized into the active treatment arm received 3 consecutive treatments (14∼16 J/cm ) approximately 4 weeks apart in the periocular region. Control eyes received 3 treatments in the same intervals of 0 J/cm . Tear samples in all eyes were collected and analyzed at baseline, week 12, and/or week 4 for interleukin (IL)-17A, IL-6, and prostaglandin E2 (PGE2). The correlations between cytokines and ocular surface parameters were analyzed before and after IPL treatment. RESULTS: All of the inflammatory markers declined in value compared to baselines. IL-17A and IL-6 showed statistically significant decreases compared to sham treatment at each measured time point. PGE2 showed statistically significant decreases compared to sham at week 12. Results showed that the expressions of IL-17A and IL-6 correlated well with ocular surface parameters of the lower eyelid before IPL. The changed values of IL-6 and PGE2 in tears correlated with the changed values of partial ocular surface parameters after IPL treatment in study eyes, respectively. CONCLUSIONS: The study results suggest that IPL can significantly reduce inflammatory markers in tears of patients suffering with DED owing to MGD after IPL treatment. These findings indicate that IL-17A and IL-6 play roles in the pathogenesis of DED owing to MGD, and the reduction of the inflammatory factors is consistent with the improvement of partial clinical symptoms and signs.
[Mh] Termos MeSH primário: Citocinas/metabolismo
Doenças Palpebrais/terapia
Terapia de Luz Pulsada Intensa/métodos
Lágrimas/metabolismo
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Biomarcadores/metabolismo
Método Duplo-Cego
Doenças Palpebrais/metabolismo
Feminino
Seguimentos
Seres Humanos
Masculino
Glândulas Tarsais/metabolismo
Meia-Idade
Estudos Retrospectivos
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Biomarkers); 0 (Cytokines)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170910
[St] Status:MEDLINE


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[PMID]:28880982
[Au] Autor:Fox TP; Schwartz JA; Chang AC; Parvin-Nejad FP; Yim CK; Feinsilver SH; Wu AY
[Ad] Endereço:Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York.
[Ti] Título:Association Between Eyelid Laxity and Obstructive Sleep Apnea.
[So] Source:JAMA Ophthalmol;135(10):1055-1061, 2017 Oct 01.
[Is] ISSN:2168-6173
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: While much has been reported on the relationship between floppy eyelid syndrome and obstructive sleep apnea (OSA), the diagnostic criteria of floppy eyelid syndrome are often subjective and vague. Objective: To evaluate the association between OSA and quantitative markers of eyelid laxity or secondary ocular surface disease in a sleep clinic population. Design, Setting, and Participants: This investigation was a cross-sectional observational study at the Center for Sleep Medicine at Icahn School of Medicine at Mount Sinai. Participants were individuals referred for overnight polysomnography from March 1 to August 30, 2015. Main Outcomes and Measures: Eyelid laxity and ocular surface disease were assessed on bedside ophthalmologic examination. The presence and severity of OSA were determined from polysomnography results. Initial correlation between OSA and ocular surface and eyelid markers was calculated through bivariate linear regression analysis, and the association between ocular symptoms was obtained through bivariate ordered logistic regression. Analysis was repeated adjusting for known associations between OSA and sex, age, body mass index, and medical comorbidities through multivariable analysis. Results: In total, 201 individuals (402 eyes) were enrolled in the study. Their mean (SD) age was 53.2 (13.5) years, 43.3% (n = 87) were female, 56.7% (n = 114) were of white race/ethnicity, 26.9% (n = 54) were black/African American, 4.0% (n = 8) were Asian, 8.0% (n = 16) were multiracial or other, and 4.5% (n = 9) were of unknown race/ethnicity, with 21.9% (n = 44) of all individuals self-identifying as Hispanic and 75.1% (n = 151) self-identifying as non-Hispanic. After adjustment, no association was observed between OSA severity and an eyelid laxity score (regression coefficient, 0.85; 95% CI, -0.33 to 0.62; P = .40) or an ocular surface score (regression coefficient, 1.09; 95% CI, -0.32 to 0.29; P = .93). Through subset analysis, male sex was associated with a higher ocular surface score, while older age and diabetes were associated with a higher eyelid laxity score. Only one patient (0.5%) exhibited findings of floppy eyelid syndrome. Conclusions and Relevance: Among individuals referred for overnight polysomnography, quantitative markers of eyelid laxity were not associated with the presence or severity of OSA. Subset analysis suggests that prior studies may have been limited by confounding variables or the technique of identifying eyelid laxity.
[Mh] Termos MeSH primário: Doenças Palpebrais/diagnóstico
Apneia Obstrutiva do Sono/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Estudos Transversais
Doenças Palpebrais/fisiopatologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Hipotonia Muscular/diagnóstico
Hipotonia Muscular/fisiopatologia
Polissonografia
Estudos Prospectivos
Fatores de Risco
Apneia Obstrutiva do Sono/fisiopatologia
Síndrome
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170908
[St] Status:MEDLINE
[do] DOI:10.1001/jamaophthalmol.2017.3263


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[PMID]:28756152
[Au] Autor:Mantagos IS; Kleinman ME; Kieran MW; Gordon LB
[Ad] Endereço:Department of Ophthalmology, Boston Children's Hospital - Harvard Medical School, Boston, Massachusetts. Electronic address: Jason.Mantagos@childrens.harvard.edu.
[Ti] Título:Ophthalmologic Features of Progeria.
[So] Source:Am J Ophthalmol;182:126-132, 2017 Oct.
[Is] ISSN:1879-1891
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To establish the natural history of ophthalmic characteristics in Progeria patients and to determine incidence of ocular manifestations. DESIGN: Retrospective case series of patients with Progeria who were seen between 2007 and 2016. METHODS: Setting: Tertiary-care academic center. PATIENT POPULATION: Fourteen patients (28 eyes) with Hutchinson-Gilford Progeria syndrome were included for statistical analysis from a total of 84 patients who have been enrolled in clinical trials for Progeria at Boston Children's Hospital. Clinical treatment trial patients who were not seen at the Department of Ophthalmology at our hospital, but for whom we had detailed clinical ophthalmologic records, were also included. This essentially represents an estimated 20% of the world's known patients with Progeria. Interventions or Observation Procedures: Complete ophthalmic examination. MAIN OUTCOME MEASURES: Visual acuity, stereoacuity, refraction, clinical findings of slit-lamp and dilated fundus examinations. RESULTS: Ophthalmic manifestations noted were hyperopia and signs of ocular surface disease owing to nocturnal lagophthalmos and exposure keratopathy. Additional ophthalmic manifestations included reduced brow hair, madarosis, and reduced accommodation. Most patients had relatively good acuity; however, advanced ophthalmic disease was associated with reduced acuity. CONCLUSIONS: Children with Progeria are at risk for serious ophthalmic complications owing to ocular surface disease. Children with Progeria should have an ophthalmic evaluation at the time of diagnosis and at least yearly after that. Aggressive ocular surface lubrication is recommended, including the use of tape tarsorrhaphy at night.
[Mh] Termos MeSH primário: Oftalmopatias/diagnóstico
Progéria/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Doenças da Córnea/diagnóstico
Oftalmopatias/fisiopatologia
Oftalmopatias/terapia
Sobrancelhas/patologia
Óculos/utilização
Doenças Palpebrais/diagnóstico
Feminino
Seguimentos
Seres Humanos
Masculino
Progéria/fisiopatologia
Progéria/terapia
Refração Ocular/fisiologia
Estudos Retrospectivos
Acuidade Visual/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170731
[St] Status:MEDLINE



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde