Base de dados : MEDLINE
Pesquisa : C11.338.204 [Categoria DeCS]
Referências encontradas : 4940 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 494 ir para página                         

  1 / 4940 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27776019
[Au] Autor:Nguyen BH; Kuo J; Budiman A; Christie H; Ali S
[Ad] Endereço:aDepartment of Medical Oncology, The Canberra Hospital bThe Australian National University, Canberra, Australian Capital Territory cHervey Bay Cancer Care Centre, Hervey Bay, Queensland, Australia.
[Ti] Título:Two cases of clinical myasthenia gravis associated with pembrolizumab use in responding melanoma patients.
[So] Source:Melanoma Res;27(2):152-154, 2017 Apr.
[Is] ISSN:1473-5636
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Immune checkpoint inhibitors have changed the landscape of the treatment of multiple solid malignancies, and have been used increasingly in the recent years. Although usually well tolerated, given the relative inexperience of using immune checkpoint inhibitors, we are still learning of new side effects from the treatment. We report on two cases of ocular myasthenia gravis that occurred after treatment with pembrolizumab, an antiprogrammed-death (anti-PD1) monoclonal antibody for advanced melanoma in responding patients. One case is in an 81-year-old man and the second case in an 86-year-old woman, both with BRAF-negative metastatic melanoma receiving pembrolizumab. These two cases of ocular only associated myasthenic syndrome appeared 7 and 11 weeks after the initiation of pembrolizumab. We conclude that the condition is most likely associated with pembrolizumab as symptoms started after treatment with pembrolizumab, neither patient had other evidence of neurological cause for presentation, and symptoms also improved rapidly with administration of steroids. Both patients showed good oncological response to anti-PD1 treatment and one patient successfully continued to receive ongoing treatment with no further complications.
[Mh] Termos MeSH primário: Anticorpos Monoclonais Humanizados/efeitos adversos
Antineoplásicos Imunológicos/efeitos adversos
Melanoma/tratamento farmacológico
Miastenia Gravis/induzido quimicamente
Neoplasias Cutâneas/tratamento farmacológico
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Blefaroptose/induzido quimicamente
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal, Humanized); 0 (Antineoplastic Agents, Immunological); DPT0O3T46P (pembrolizumab)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1097/CMR.0000000000000310


  2 / 4940 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29390531
[Au] Autor:Tu Y; Gao F
[Ad] Endereço:Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
[Ti] Título:Dexmedetomidine-based monitored conscious sedation combined local anesthesia for levator resection in a 10-year-old child with Marcus Gunn jaw-winking synkinesis: A case report.
[So] Source:Medicine (Baltimore);96(51):e9369, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Levator resection has become a routine procedure for patients with severe Marcus Gunn jaw-winking synkinesis (MGJWS). To optimize the surgical outcome, adult patients need to be kept awake, or easily aroused and responsive to verbal commands during the operation. However, levator resection is commonly performed under general anesthesia in pediatric patients. In the present case, we described a successful anesthetic protocol of conscious sedation with local anesthesia for levator resection in a child. PATIENT CONCERNS: A 10-year-old boy with MGJWS was admitted to our hospital and scheduled for levator resection. The patient was born through a normal delivery and had no previous history of allergy, no comorbidity, and no history of receiving anesthesia or operation. The laboratory tests of the patient were unremarkable. DIAGNOSES: The diagnosis of MGJWS was made by two experienced ophthalmologists. INTERVENTIONS: A 10-year-old boy with MGJWS was admitted to our hospital and scheduled for levator resection. The levator resection was performed under monitored conscious sedation with dexmedetomidine and local anesthesia. OUTCOMES: Patient with spontaneous breathing responded normally to verbal commands throughout the operation, and no adverse events occurred. The patient and ophthalmologist reported high satisfaction with anesthesia management. LESSONS: Dexmedetomidine-based monitored conscious sedation with local anesthesia is a feasible alternative to general anesthesia for levator resection in collaborative patients.
[Mh] Termos MeSH primário: Blefaroptose/diagnóstico
Blefaroptose/terapia
Dexmedetomidina/administração & dosagem
Cardiopatias Congênitas/diagnóstico
Cardiopatias Congênitas/terapia
Anormalidades Maxilomandibulares/diagnóstico
Anormalidades Maxilomandibulares/terapia
Monitorização Fisiológica/métodos
Doenças do Sistema Nervoso/diagnóstico
Doenças do Sistema Nervoso/terapia
Músculos Oculomotores/cirurgia
[Mh] Termos MeSH secundário: Anestesia Local
Criança
Sedação Consciente/métodos
Seguimentos
Seres Humanos
Masculino
Doenças Raras
Reflexo Anormal
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
67VB76HONO (Dexmedetomidine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009369


  3 / 4940 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29303940
[Au] Autor:Putterman AM; Liu CY
[Ti] Título:Simplified Treatment of Over- and Under-Corrected Blepharoptosis Surgery.
[So] Source:Ophthal Plast Reconstr Surg;34(1):90-92, 2018 Jan/Feb.
[Is] ISSN:1537-2677
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Blefaroplastia/métodos
Blefaroptose/cirurgia
Pálpebras/cirurgia
[Mh] Termos MeSH secundário: Seres Humanos
Resultado do Tratamento
[Pt] Tipo de publicação:LETTER
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1097/IOP.0000000000001014


  4 / 4940 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29394920
[Au] Autor:Vanikieti K; Poonyathalang A; Jindahra P; Cheecharoen P; Chokthaweesak W
[Ad] Endereço:Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Bangkok, 10400, Thailand.
[Ti] Título:Occipital lobe infarction: a rare presentation of bilateral giant cavernous carotid aneurysms: a case report.
[So] Source:BMC Ophthalmol;18(1):25, 2018 Feb 02.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cavernous carotid aneurysm (CCA) represents 2-9% of all intracranial aneurysms and 15% of internal carotid artery (ICA) aneurysms; additionally, giant aneurysms are those aneurysms that are > 25 mm in size. Bilateral CCAs account for 11-29% of patients and are commonly associated with structural weaknesses in the ICA wall, secondary to systemic hypertension. CCAs are considered benign lesions, given the low risk for developing major neurologic morbidities (i.e., subarachnoid hemorrhage, cerebral infarction, or carotid cavernous fistula). Moreover, concurrent presentation with posterior circulation cerebral infarction is even rarer, given different circulation territory from CCA. Here, we report on a patient with bilateral giant CCAs who presented with both typical and atypical symptoms. CASE PRESENTATION: An 88-year-old hypertensive woman presented with acute vertical oblique binocular diplopia, followed by complete ptosis of the right eye. Ophthalmic examination showed dysfunction of the right third, fourth, and sixth cranial nerves. Further examination revealed hypesthesia of the areas supplied by the ophthalmic (V1) and maxillary (V2) branches of the right trigeminal nerve. Bilateral giant cavernous carotid aneurysms, with a concurrent subacute right occipital lobe infarction, were discovered on brain imaging and angiogram. Additionally, a prominent right posterior communicating artery (PCOM) was revealed. Seven months later, clinical improvement with stable radiographic findings was documented without any intervention. CONCLUSIONS: Dysfunction of the third, fourth, and sixth cranial nerves, and the ophthalmic (V ) and maxillary (V ) branches of the trigeminal nerves, should necessitate brain imaging, with special attention given to the cavernous sinus. Despite unilateral symptomatic presentation, bilateral lesions cannot be excluded solely on the basis of clinical findings. CCA should be included in the differential diagnosis of cavernous sinus lesions. Although rare, ipsilateral posterior circulation cerebral infarction (i.e., occipital lobe infarction) can occur in CCA patients, presumably as a result of distal embolization through an ipsilateral, prominent PCOM. Spontaneous clinical improvement with stable radiographic support may occur.
[Mh] Termos MeSH primário: Infarto Encefálico/diagnóstico por imagem
Doenças das Artérias Carótidas/diagnóstico por imagem
Artéria Carótida Interna/diagnóstico por imagem
Trombose do Corpo Cavernoso/diagnóstico por imagem
Aneurisma Intracraniano/diagnóstico por imagem
Lobo Occipital/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Blefaroptose/diagnóstico
Artéria Carótida Interna/patologia
Diplopia/diagnóstico
Feminino
Seres Humanos
Angiografia por Ressonância Magnética
Imagem por Ressonância Magnética
Lobo Occipital/patologia
Campos Visuais
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180204
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0687-4


  5 / 4940 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29390490
[Au] Autor:Zhu Y; Sun C; Zhang X; Shentu X
[Ad] Endereço:Eye Center, 2nd Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, Zhejiang, China.
[Ti] Título:Ptosis induced by topical steroid eye drops: Two cases reports.
[So] Source:Medicine (Baltimore);96(51):e9288, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Ptosis is a rare complication of periocular steroid use. Studies report that local injections of steroids produce ptosis. We describe the first 2 cases of ptosis because of long-term treatment with topical steroid eye drops. PATIENT CONCERNS: Two cases admitted to our hospital because of ptosis of their right eye after long-term treatment with topical steroid eye drops. Both of them had uncontrolled Posner-Schlossman syndrome. DIAGNOSIS: Two cases were diagnosed as steroid-related ptosis. INTERVENTIONS: Regulatory anti-inflammation therapy was prescribed for case 1, and after inflammation control, phacoemulsification was done for her. Six months after steroid withdrawal, the levator resection of the right eye was performed. Case 2 refused our advice of steroid reduction and ptosis surgery. OUTCOMES: After surgery, case 1 retained a symmetrical appearance during a 1-year follow-up. In the surgery, we found thin levator muscles and slack levator palpebrae superioris aponeurosis (LPSA) in the affected eye. Postoperative transmission electron microscopy revealed typical signs of apoptosis in levator muscle cells. LESSONS: We suggest topical application of steroids induces levator muscle apoptosis and LPSA weakness, and results in ptosis.
[Mh] Termos MeSH primário: Corticosteroides/efeitos adversos
Blefaroptose/induzido quimicamente
Extração de Catarata/métodos
Músculos Oculomotores/efeitos dos fármacos
Soluções Oftálmicas/efeitos adversos
Facoemulsificação/métodos
[Mh] Termos MeSH secundário: Corticosteroides/uso terapêutico
Adulto
Blefaroplastia/métodos
Blefaroptose/cirurgia
Catarata/diagnóstico
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Cuidados Pós-Operatórios
Medição de Risco
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Ophthalmic Solutions)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009288


  6 / 4940 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28743241
[Au] Autor:Herath HMMTB; Pahalagamage SP; Withana D; Senanayake S
[Ad] Endereço:National Hospital, Colombo, Sri Lanka. tharukaherath11@gmail.com.
[Ti] Título:Complete ophthalmoplegia, complete ptosis and dilated pupil due to internal carotid artery dissection: as the first manifestation of Takayasu arteritis.
[So] Source:BMC Cardiovasc Disord;17(1):201, 2017 07 25.
[Is] ISSN:1471-2261
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Takayasu arteritis is a rare, chronic large vessel vasculitis involving the aorta and its primary branches. As the disease progresses, the active inflammation of large vessels leads to dilation, narrowing and occlusion of the arteries. Arterial dissection is due to separation of the layers of the arterial wall resulting in a false lumen, where blood seeps into the vessel wall. Neurological sequelae of intracranial arterial dissection results from cerebral ischemia due to thromboembolism and hypo perfusion. Internal carotid artery dissection in Takayasu arteritis is very rare and complete ophthalmoplegia due to internal carotid artery dissection is also rare. This is the first case report of Takayasu arteritis presenting as complete ophthalmoplegia due to internal carotid artery dissection. CASE PRESENTATION: A 38-year-old Sri Lankan female presented with sudden onset severe headache, fixed dilated pupil, complete ptosis and ophthalmoplegia on the right side. On imaging, dissection and dilatation was evident in the right internal carotid artery from the origin up to the cavernous segment. She also had stenosis and aneurysmal dilatation of right subclavian artery. Takayasu arteritis was diagnosed subsequently. She was started on aspirin and high dose steroids. CONCLUSIONS: Internal carotid artery dissection within the cavernous sinus can lead to third, fourth and sixth nerve palsy due to compression, stretching and ischemia from occlusion of the nutritional arteries. This case report illustrates that internal carotid artery dissection should be a differential diagnosis in palsies of the third, fourth, or sixth cranial nerves, especially when associated with headache. In cases of internal carotid artery dissection, vasculitis such as Takayasu arteritis should also be considered.
[Mh] Termos MeSH primário: Aneurisma Dissecante/etiologia
Blefaroptose/etiologia
Doenças das Artérias Carótidas/etiologia
Artéria Carótida Interna
Aneurisma Intracraniano/etiologia
Oftalmoplegia/etiologia
Pupila
Arterite de Takayasu/complicações
[Mh] Termos MeSH secundário: Adulto
Aneurisma Dissecante/diagnóstico por imagem
Angiografia Digital
Aspirina/administração & dosagem
Blefaroptose/diagnóstico
Blefaroptose/fisiopatologia
Doenças das Artérias Carótidas/diagnóstico por imagem
Artéria Carótida Interna/diagnóstico por imagem
Angiografia Cerebral/métodos
Angiografia por Tomografia Computadorizada
Feminino
Seres Humanos
Aneurisma Intracraniano/diagnóstico por imagem
Imagem por Ressonância Magnética
Oftalmoplegia/diagnóstico
Oftalmoplegia/fisiopatologia
Esteroides/administração & dosagem
Arterite de Takayasu/diagnóstico
Arterite de Takayasu/tratamento farmacológico
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Steroids); R16CO5Y76E (Aspirin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1186/s12872-017-0638-7


  7 / 4940 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:28457112
[Au] Autor:Knyazer B; Smolar J; Lazar I; Rosenberg E; Tsumi E; Lifshitz T; Levy J
[Ad] Endereço:Department of Ophthalmology, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
[Ti] Título:Iatrogenic Horner Syndrome: Etiology, Diagnosis and Outcomes.
[So] Source:Isr Med Assoc J;19(1):34-38, 2017 Jan.
[Is] ISSN:1565-1088
[Cp] País de publicação:Israel
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The identification and prompt diagnosis of Horner syndrome (HS) is essential for preventing permanent damage. HS may arise when a lesion presents anywhere along the three-neuron oculosympathetic pathway that begins at the posterior-lateral nuclei of the hypothalamus all the way through to the orbit. We present four cases and review the literature to familiarize the reader with the identification, diagnosis and treatment of Horner syndrome. The four patients, three adults and one child, were followed for at least 6 months following the initial diagnosis (range 6-18 months). There was partial resolution in three of the four cases, while the fourth resolved completely. There are numerous causes of HS, some of them iatrogenic. While iatrogenic cases of HR are rare in both adults and children, HS is seen more often following surgical procedures. Prompt recognition of the syndrome and correction of the offending agent may prevent permanent damage to the neuronal pathway. It is therefore recommended that practitioners be aware of the risks for development of iatrogenic HS and the signs for early detection.
[Mh] Termos MeSH primário: Síndrome de Horner/diagnóstico
Síndrome de Horner/etiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Anisocoria/etiologia
Blefaroptose/etiologia
Feminino
Seres Humanos
Doença Iatrogênica
Lactente
Masculino
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


  8 / 4940 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28991354
[Au] Autor:Kassem RR
[Ti] Título:Anteriorization of the Normally Acting Inferior Oblique Muscles to Treat Dissociated Vertical Deviation Associated With Juvenile Glaucoma.
[So] Source:J Pediatr Ophthalmol Strabismus;54:e63-e66, 2017 Oct 09.
[Is] ISSN:1938-2405
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A case of dissociated vertical deviation, ptosis, and juvenile glaucoma is described. J deformity anteriorization of the normally acting inferior oblique muscles was chosen to preserve the superior fornix for glaucoma surgeries by avoiding superior rectus recession and to prevent narrowing of the palpebral fissure by avoiding an inferior rectus tuck. [J Pediatr Ophthalmol Strabismus. 2017;54:e63-e66.].
[Mh] Termos MeSH primário: Blefaroplastia/métodos
Blefaroptose/cirurgia
Pálpebras/cirurgia
Glaucoma/complicações
Músculos Oculomotores/cirurgia
[Mh] Termos MeSH secundário: Blefaroptose/etiologia
Pré-Escolar
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171010
[St] Status:MEDLINE
[do] DOI:10.3928/01913913-20170907-05


  9 / 4940 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28926665
[Au] Autor:Ural Ö; Mocan MC; Erdener U
[Ti] Título:The Value of the Frontalis Suspension Procedure as a Repeat Intervention in Congenital Blepharoptosis.
[So] Source:J Pediatr Ophthalmol Strabismus;54(5):320-323, 2017 Sep 01.
[Is] ISSN:1938-2405
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To evaluate the therapeutic benefits of frontalis suspension as a repeat intervention in congenital blepharoptosis. METHODS: Pediatric patients diagnosed as having congenital ptosis who had at least 2 years of postoperative follow-up were included in this retrospective study. A successful outcome was defined as a postoperative margin-reflex distance of 3 mm or greater. The chi-square, Student's t, and Mann-Whitney U tests were used in comparisons. RESULTS: Eighty-four eyes of 77 patients with a follow-up period of 8.4 ± 0.7 years were included. The initial surgery was levator resection in 29 (34.5%) eyes and frontalis suspension in 55 (65.5%) eyes. Frontalis suspension was performed for all repeat interventions (n = 20). Surgical success was achieved in 61.9% of patients with single surgery (75.9% for levator resection vs 54.5% for frontalis suspension; P = .06) and in 77.4% of patients following repeated surgeries (93.1% vs 69.1% for patients who initially underwent levator resection vs frontalis suspension, respectively; P = .012). A higher success rate was associated with better preoperative levator function (P = .01) and a higher margin-reflex distance (P = .004), and was inversely proportional to ptosis severity (P = .04). CONCLUSIONS: Frontalis suspension as a repeat intervention for congenital blepharoptosis is associated with a further increase in long-term anatomic success rates and should be considered when initial procedures fail or remain inadequate. [J Pediatr Ophthalmol Strabismus. 2017;54(5):320-323.].
[Mh] Termos MeSH primário: Blefaroplastia/métodos
Blefaroptose/cirurgia
Pálpebras/cirurgia
Músculos Oculomotores/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Blefaroptose/congênito
Criança
Pré-Escolar
Feminino
Seguimentos
Seres Humanos
Lactente
Recém-Nascido
Masculino
Reoperação
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE
[do] DOI:10.3928/01913913-20170801-01


  10 / 4940 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28885362
[Au] Autor:Chen L; Pi L; Ke N; Chen X; Liu Q
[Ad] Endereço:Department of Ophthalmology, Children's Hospital, Chongqing Medical University, Chongqing, China.
[Ti] Título:The protective efficacy and safety of bandage contact lenses in children aged 5 to 11 after frontalis muscle flap suspension for congenital blepharoptosis: A single-center randomized controlled trial.
[So] Source:Medicine (Baltimore);96(36):e8003, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Postoperative complications, lagophthalmos and exposure keratopathy sometimes occur after surgery for congenital blepharoptosis. Bandage contact lenses (BCL) can help prevent some ocular surface disorders. The study aims to evaluate the efficacy and safety of BCL for protection of the ocular surface in children aged 5 to 11 years after frontalis muscle flap suspension for congenital blepharoptosis. METHODS: We conducted a prospective randomized clinical study of 30 eyes of 30 patients with congenital blepharoptosis consecutively enrolled at the Ophthalmology Ward of the Children's Hospital of Chongqing Medical University, China from September 1, 2016, to February 30, 2017. After frontalis muscle flap suspension surgery, patients were randomly assigned to undergo BCL application (BCL group, 15 eyes) or no BCL application (control group, 15 eyes). All patients were treated with bramycin 0.3% and polyvinyl alcohol drops after surgery. The primary outcomes were dry eye assessed by tear film break time (TFBUT), fluoresce in corneal staining (FCS) on slit-lamp on days 1, 3, and 15 postoperatively, and lower tear meniscus height (LTMH) on optical coherence tomography on days 1 and 15 postoperatively. Secondary outcomes were pairwise correlation of TFBUT, FCS and LTMH. RESULTS: In the BCL group, abnormal TFBUT and FCS were only found in 2 patients (13.33%) on postoperative day 15. In the control group, the incidence of dry eye assessed by TFBUT was 67.00% (10/15 eyes) on day 1, 73.33% (11/15 eyes) on day 3, and 53.33% (8/15 eyes) on day 15 (P < .001). LTMH were significantly higher in the BCL group than the control group postoperatively (P < .001). Significant positive correlations were found between LTMH and TFBUT pre-operation and on days 1 and 15 post-operation. For LTMH and FCSS (R = -0.815, P < .001), and TFBUT and FCS (R = -0.837, P < .001), the Pearson coefficient was negative on postoperative day 1, but not correlated on day 15. CONCLUSIONS: Silicone hydrogel BCL were safe and efficacious for protective use in children after frontalis muscle flap suspension for congenital blepharoptosis.
[Mh] Termos MeSH primário: Bandagens
Blefaroptose/terapia
Lentes de Contato
Complicações Pós-Operatórias/prevenção & controle
Retalhos Cirúrgicos
[Mh] Termos MeSH secundário: Anti-Infecciosos/administração & dosagem
Blefaroptose/diagnóstico por imagem
Criança
Pré-Escolar
Síndromes do Olho Seco/diagnóstico por imagem
Síndromes do Olho Seco/prevenção & controle
Feminino
Seguimentos
Seres Humanos
Hidrogéis
Masculino
Soluções Oftálmicas
Álcool de Polivinil/administração & dosagem
Complicações Pós-Operatórias/diagnóstico por imagem
Silicones
Tomografia de Coerência Óptica
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Hydrogels); 0 (Ophthalmic Solutions); 0 (Silicones); 9002-89-5 (Polyvinyl Alcohol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008003



página 1 de 494 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde