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[PMID]:28801699
[Au] Autor:Kaplowitz K; Tsai JC
[Ad] Endereço:Loma Linda VA, Loma Linda University, 11201 Benton St, Loma, Linda, CA, 92357, USA.
[Ti] Título:Use of subconjunctival injections of 5-fluorouracil to rescue and prolong intraocular pressure reduction for a failing Ahmed glaucoma implant.
[So] Source:Graefes Arch Clin Exp Ophthalmol;255(11):2295, 2017 11.
[Is] ISSN:1435-702X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Mh] Termos MeSH primário: Fluoruracila
Pressão Intraocular
[Mh] Termos MeSH secundário: Glaucoma
Implantes para Drenagem de Glaucoma
Seres Humanos
Injeções
Hipotensão Ocular
Complicações Pós-Operatórias
Resultado do Tratamento
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
U3P01618RT (Fluorouracil)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170813
[St] Status:MEDLINE
[do] DOI:10.1007/s00417-017-3769-8


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[PMID]:28723783
[Au] Autor:Tang J; Du E; Wang J
[Ad] Endereço:Department of Ophthalmology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
[Ti] Título:Novel surgical management of cyclodialysis cleft via anterior chamber perfusion: Case report.
[So] Source:Medicine (Baltimore);96(29):e7559, 2017 Jul.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Cyclodialysis cleft is a relatively rare but severe condition with persistent ocular hypotony, which can cause morphologic changes and visual loss. Here we report a case of a traumatic cyclodialysis cleft that was successfully managed with direct cyclopexy via anterior chamber perfusion. During the operation, if there is aqueous humor flowing out of the deep scleral incision, the cleft is not closed, and surgery should continue until there is no aqueous outflow. PATIENT CONCERNS: A 66-year-old man was treated for severe blunt ocular trauma of the left eye and a resultant cyclodialysis cleft, lens subluxation, choroidal detachment and a cataract. His intraocular pressure was 6 mm Hg, he presented with a shallow anterior chamber, phacodonesis, iridodonesis, 360° ciliary body detachment, and a suspicious cyclodialysis cleft in the 5 to 8 o'clock position. DIAGNOSES:: ocular blunt trauma (left eye), cyclodialysis cleft (left eye), lens subluxation (left eye), choroidal detachment (left eye), cataract (both eyes). INTERVENTIONS: The cataract was extracted by phacoemulsification and a posterior chamber intraocular lens was implanted with 2 capsular tension rings, one in the lens bag and the other in the ciliary sulcus. Throughout the following month, intraocular pressure fluctuated between 4 and 6 mm Hg and the ciliary body failed to reattach. A cyclopexy via anterior chamber perfusion was thus deemed necessary and performed. OUTCOMES: After cyclopexy, intraocular pressure increased to 27 mm Hg and decreased to 16 mm Hg after brinzolamide eye drops treatment twice daily for 4 days. Subsequently intraocular pressure stabilized between 10 to 21mm Hg. Complete closure of the cyclodialysis cleft was confirmed with ultrasound biomicroscopy. LESSONS: Cyclopexy via anterior chamber perfusion for patients with cyclodialysis cleft is a simple, safe, and efficient technique that ensures a successful surgery.
[Mh] Termos MeSH primário: Câmara Anterior/cirurgia
Traumatismos Oculares/complicações
Hipotensão Ocular/cirurgia
[Mh] Termos MeSH secundário: Idoso
Câmara Anterior/diagnóstico por imagem
Câmara Anterior/efeitos dos fármacos
Catarata/complicações
Catarata/diagnóstico
Catarata/tratamento farmacológico
Extração de Catarata
Doenças da Coroide/diagnóstico
Doenças da Coroide/tratamento farmacológico
Doenças da Coroide/etiologia
Doenças da Coroide/cirurgia
Traumatismos Oculares/diagnóstico
Traumatismos Oculares/tratamento farmacológico
Seres Humanos
Implante de Lente Intraocular
Masculino
Hipotensão Ocular/diagnóstico
Hipotensão Ocular/tratamento farmacológico
Hipotensão Ocular/etiologia
Complicações Pós-Operatórias/diagnóstico por imagem
Complicações Pós-Operatórias/tratamento farmacológico
Complicações Pós-Operatórias/cirurgia
Ferimentos não Penetrantes/complicações
Ferimentos não Penetrantes/diagnóstico
Ferimentos não Penetrantes/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007559


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[PMID]:28692596
[Au] Autor:Berk TA; An JA; Ahmed IIK
[Ad] Endereço:*Department of Ophthalmology, McGill University, Montréal, QC ‡Department of Ophthalmology and Vision Sciences, University of Toronto Faculty of Medicine, Toronto §Trillium Health Partners, Mississauga ∥Prism Eye Institute, Mississauga, ON, Canada †Department of Ophthalmology, Mason Eye Institute, University of Missouri School of Medicine, Columbia, MO.
[Ti] Título:Inadvertent Cyclodialysis Cleft and Hypotony Following Ab-Interno Trabeculotomy Using the Trabectome Device Requiring Surgical Repair.
[So] Source:J Glaucoma;26(8):742-746, 2017 Aug.
[Is] ISSN:1536-481X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To report the first case of inadvertent cyclodialysis cleft and hypotony requiring surgical repair following ab-interno trabeculotomy (AIT) using the Trabectome device, and the postoperative clinical results following direct suture cyclopexy. METHODS: A 55-year-old man with hypotonous maculopathy secondary to cyclodialysis cleft inadvertently created 3 years earlier during AIT using the Trabectome device was referred for repair. Direct suture cyclopexy was performed and topical homatropine and dexamethasone drops were prescribed postoperatively. RESULTS: Gonioscopic examination revealed complete cleft closure on postoperative day 1 confirmed by anterior segment optical coherence tomography. At 11 weeks postoperatively, visual acuity had improved from 20/400 to 20/40, with resolution of preoperative macular folds on fundoscopic examination. At 9 months postoperatively, visual acuity had further improved to 20/20 with intraocular pressure stable at 9 mm Hg maintained on travoprost and brimonidine. CONCLUSIONS: Inadvertent cyclodialysis cleft from a malpositioned AIT and resultant hypotony is rare and in this case was successfully treated by direct suture cyclopexy.
[Mh] Termos MeSH primário: Corpo Ciliar/lesões
Traumatismos Oculares/etiologia
Hipotensão Ocular/etiologia
Esclera/lesões
Trabeculectomia/efeitos adversos
[Mh] Termos MeSH secundário: Corpo Ciliar/patologia
Traumatismos Oculares/diagnóstico
Traumatismos Oculares/cirurgia
Glaucoma de Ângulo Aberto/cirurgia
Gonioscopia
Seres Humanos
Doença Iatrogênica
Pressão Intraocular/fisiologia
Masculino
Meia-Idade
Hipotensão Ocular/diagnóstico
Hipotensão Ocular/cirurgia
Esclera/patologia
Tomografia de Coerência Óptica
Tonometria Ocular
Trabeculectomia/instrumentação
Acuidade Visual/fisiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170711
[St] Status:MEDLINE
[do] DOI:10.1097/IJG.0000000000000719


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[PMID]:28660275
[Au] Autor:Jasien JV; Huisingh C; Girkin CA; Downs JC
[Ad] Endereço:Vision Science Graduate Program, School of Optometry, University of Alabama at Birmingham, Birmingham, Alabama, United States.
[Ti] Título:The Magnitude of Hypotony and Time Course of Intraocular Pressure Recovery Following Anterior Chamber Cannulation in Nonhuman Primates.
[So] Source:Invest Ophthalmol Vis Sci;58(7):3225-3230, 2017 Jun 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To determine the magnitude of ocular hypotony and the length of recovery time to 6 and 10 mm Hg IOP following anterior chamber (AC) cannulation. Methods: Bilateral IOP was recorded 500 times per second via telemetry immediately before, during, and immediately after AC cannulation with a 27-G needle in 10 different sessions at least 2 weeks apart in four male rhesus macaques (nonhuman primates; NHPs) aged 3- to 6-years old. Bilateral IOP was recorded continuously using a proven telemetry system while the NHPs were under general anesthesia during IOP transducer calibration experiments involving manometric control of IOP via AC cannulation, then continuously after the AC needles were removed until IOP recovered to precannulation levels. The change in IOP from baseline to AC cannulation was tested using the signed-rank test. The times necessary for IOP to recover to 6 and 10 mm Hg, respectively, were calculated. Results: Average precannulation IOP was 11.5 mm Hg and significantly decreased to an average of 2.3 mm Hg immediately following AC needle removal (P = 0.0156). On average, IOP recovered from 2.3 to 6 and 10 mm Hg in 32.4 and 63.7 minutes, respectively. Recovery times of IOP were not affected by repeated AC cannulations every 2 weeks. Conclusions: Generally, IOP recovers relatively quickly after repeated AC cannulation, and did not result in extended duration hypotony. It is important to consider hypotony in animal experiments and clinical procedures involving AC cannulation and paracentesis when consideration of IOP or its effects is important.
[Mh] Termos MeSH primário: Câmara Anterior/fisiopatologia
Cateterismo
Pressão Intraocular/fisiologia
Hipotensão Ocular/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Macaca mulatta
Recuperação de Função Fisiológica/fisiologia
Análise de Regressão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-21833


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[PMID]:28615113
[Au] Autor:Tseng VL; Kim CH; Romero PT; Yu F; Robertson-Brown KW; Phung L; Raygoza D; Caprioli J; Coleman AL
[Ad] Endereço:Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
[Ti] Título:Risk Factors and Long-Term Outcomes in Patients with Low Intraocular Pressure after Trabeculectomy.
[So] Source:Ophthalmology;124(10):1457-1465, 2017 Oct.
[Is] ISSN:1549-4713
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To examine risk factors for low intraocular pressure (IOP) after trabeculectomy and to describe long-term outcomes in these eyes. DESIGN: Retrospective case-control study. PARTICIPANTS: Cases with low IOP included all patients with IOP ≤5 mmHg on 3 or more consecutive visits 3 months or later after trabeculectomy. Control patients without low IOP after trabeculectomy were randomly selected at a 1:2 case-to-control ratio. METHODS: A case-control study was performed of patients undergoing trabeculectomy at the Stein Eye Institute. Covariates included demographics, history of cataract surgery, refractive error, number of glaucoma medications, family history of glaucoma, diabetes, hypertension, visual acuity (VA), IOP, number of sutures in the scleral flap, laser suture lysis, surgeon, and laterality of surgery. Logistic regression modeling was used to examine associations between each covariate and low IOP. Postoperative outcomes that were examined included reoperation, vision loss, and surgical failure. The time between trabeculectomy and each outcome was compared between cases and controls with Cox proportional hazards regression modeling. MAIN OUTCOME MEASURES: Low IOP after trabeculectomy, reoperation, vision loss, and surgical failure. RESULTS: Of 3659 total trabeculectomies performed by 5 surgeons between 1990 and 2013, 64 eyes had low IOP (1.7%), which were compared with 130 control eyes. Fifteen of the 64 eyes with low IOP had hypotony maculopathy (23.4%). After accounting for differences in baseline IOP, laser suture lysis was negatively correlated with low IOP after trabeculectomy (odds ratio [OR], 0.33; 95% confidence interval [CI], 0.13-0.87); surgeon was correlated with high vs. low IOP after trabeculectomy (OR, 5.32; 95% CI, 1.53-18.52). There were no statistically significant associations between low IOP and time to reoperation (hazard ratio [HR], 0.73; 95% CI, 0.32-1.68), vision loss (HR, 1.77; 95% CI, 0.81-3.88) or surgical failure (HR, 1.14; 95% CI, 0.62-2.11). In patients with low IOP, there was a higher unadjusted incidence of bleb revision in patients who had maculopathy (7.6 vs. 1.9 revisions/100 person-years; for maculopathy versus no maculopathy P = 0.008). CONCLUSIONS: The absence of laser suture lysis and surgeon are factors potentially associated with low IOP after trabeculectomy. Numeric hypotony does not necessarily represent clinical failure after trabeculectomy.
[Mh] Termos MeSH primário: Pressão Intraocular/fisiologia
Hipotensão Ocular/etiologia
Complicações Pós-Operatórias
Trabeculectomia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Estudos de Casos e Controles
Feminino
Seguimentos
Glaucoma de Ângulo Aberto/cirurgia
Seres Humanos
Masculino
Meia-Idade
Hipotensão Ocular/fisiopatologia
Modelos de Riscos Proporcionais
Reoperação
Estudos Retrospectivos
Fatores de Risco
Tonometria Ocular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE


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[PMID]:28604498
[Au] Autor:Lincoff NS; Buccilli A; Weinstock-Guttman B; Sieminski S; Gandhi S
[Ad] Endereço:Department of Neurology and Ophthalmology (NSL), State University of New York at Buffalo School of Medicine, Buffalo, New York; Jacobs MS Center (NSL, BW-G, SG), UBMD Neurology, State University of New York, Buffalo, New York; Ophthalmology Clinic (AB), Lockport, New York; and Ross Eye Institute (SS), University at Buffalo, Buffalo, New York.
[Ti] Título:Is Multiple Sclerosis Associated With a Lower Intraocular Pressure?
[So] Source:J Neuroophthalmol;37(3):265-267, 2017 Sep.
[Is] ISSN:1536-5166
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine if multiple sclerosis (MS) is associated with lower intraocular pressure (IOP) compared with individuals without MS. METHODS: Thirty patients with clinically definite MS were identified and a retrospective chart review was conducted. Each patient with MS underwent IOP recording by a single investigator using kinetic applanation tonometry. Measurement of central corneal thickness (CCT) also was obtained. Similarly, 30 study controls were identified and kinetic applanation tonometry and CCT were recorded. Univariate analysis of covariance was conducted to determine a statistically significant difference between IOP between MS and control groups, controlling for age. RESULTS: Analyses were adjusted for age and 2 subjects were excluded because of steroid use. The average IOP in MS group was 12.3 mm Hg (right eye = 12.3 mm Hg, left eye = 12.2 mm Hg) and in the control group was 17 mm Hg (right eye = 16.9 mm Hg, left eye = 17 mm Hg). There was a significant effect of presence of MS on IOP accounting for 53% variability in mean IOP (F(1,55) = 60.7; P < 0.001) when compared with the control group. CONCLUSIONS: This study demonstrated that IOP was significantly lower in patients with MS compared with controls. A more in-depth prospective study design is required, along with further investigation of possible etiologies. Identifying the mechanism of decreased IOP in patients with MS might allow development of new-targeted therapies for the treatment of glaucoma.
[Mh] Termos MeSH primário: Pressão Intraocular/fisiologia
Esclerose Múltipla/complicações
Hipotensão Ocular/etiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Esclerose Múltipla/fisiopatologia
Hipotensão Ocular/diagnóstico
Hipotensão Ocular/fisiopatologia
Estudos Retrospectivos
Tonometria Ocular
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE
[do] DOI:10.1097/WNO.0000000000000520


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[PMID]:28594895
[Au] Autor:Roy Chowdhury U; Bahler CK; Holman BH; Fautsch MP
[Ad] Endereço:Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, United States of America.
[Ti] Título:ATP-sensitive potassium (KATP) channel openers diazoxide and nicorandil lower intraocular pressure by activating the Erk1/2 signaling pathway.
[So] Source:PLoS One;12(6):e0179345, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Elevated intraocular pressure is the most prevalent and only treatable risk factor for glaucoma, a degenerative disease of the optic nerve. While treatment options to slow disease progression are available, all current therapeutic and surgical treatments have unwanted side effects or limited efficacy, resulting in the need to identify new options. Previous reports from our laboratory have established a novel ocular hypotensive effect of ATP-sensitive potassium channel (KATP) openers including diazoxide (DZ) and nicorandil (NCD). In the current study, we evaluated the role of Erk1/2 signaling pathway in KATP channel opener mediated reduction of intraocular pressure (IOP). Western blot analysis of DZ and NCD treated primary normal trabecular meshwork (NTM) cells, human TM (isolated from perfusion cultures of human anterior segments) and mouse eyes showed increased phosphorylation of Erk1/2 when compared to vehicle treated controls. DZ and NCD mediated pressure reduction (p<0.02) in human anterior segments (n = 7 for DZ, n = 4 for NCD) was abrogated by U0126 (DZ + U0126: -9.7 ± 11.5%, p = 0.11; NCD + U0126: -0.1 ± 11.5%, p = 1.0). In contrast, U0126 had no effect on latanoprostfree acid-induced pressure reduction (-52.5 ± 6.8%, n = 4, p = 0.001). In mice, DZ and NCD reduced IOP (DZ, 14.9 ± 3.8%, NCD, 16.9 ± 2.5%, n = 10, p<0.001), but the pressure reduction was inhibited by U0126 (DZ + U0126, 0.7 ± 3.0%; NCD + U0126, 0.9 ± 2.2%, n = 10, p>0.1). Histologic evaluation of transmission electron micrographs from DZ + U0126 and NCD + U0126 treated eyes revealed no observable morphological changes in the ultrastructure of the conventional outflow pathway. Taken together, the results indicate that the Erk1/2 pathway is necessary for IOP reduction by KATP channel openers DZ and NCD.
[Mh] Termos MeSH primário: Diazóxido/farmacologia
Pressão Intraocular/efeitos dos fármacos
Ativação do Canal Iônico/efeitos dos fármacos
Canais KATP/metabolismo
Sistema de Sinalização das MAP Quinases/efeitos dos fármacos
Nicorandil/farmacologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Animais
Butadienos/farmacologia
Células Cultivadas
Ativação Enzimática/efeitos dos fármacos
Seres Humanos
Lactente
Camundongos Endogâmicos C57BL
Meia-Idade
Nitrilos/farmacologia
Hipotensão Ocular/fisiopatologia
Perfusão
Fosforilação/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Butadienes); 0 (KATP Channels); 0 (Nitriles); 0 (U 0126); 260456HAM0 (Nicorandil); O5CB12L4FN (Diazoxide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179345


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[PMID]:28538979
[Au] Autor:Roddy GW; Viker KB; Winkler NS; Bahler CK; Holman BH; Sheikh-Hamad D; Roy Chowdhury U; Stamer WD; Fautsch MP
[Ad] Endereço:Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, United States.
[Ti] Título:Stanniocalcin-1 Is an Ocular Hypotensive Agent and a Downstream Effector Molecule That Is Necessary for the Intraocular Pressure-Lowering Effects of Latanoprost.
[So] Source:Invest Ophthalmol Vis Sci;58(5):2715-2724, 2017 May 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To identify downstream signaling molecules through which intraocular pressure (IOP) is lowered following treatment with the prostaglandin analog latanoprost. Methods: Total RNA and protein isolated from primary human Schlemm's canal cells (n = 3) treated with latanoprost (free acid; 100 nM) were processed for quantitative PCR and Western blot analysis. IOP was evaluated in stanniocalcin-1 (STC-1-/-) and wild-type mice following treatment with latanoprost or Rho kinase inhibitor Y27632. Human anterior segment pairs (n = 8) were treated with recombinant STC-1 (5, 50, or 500 ng/mL) and pressure was recorded using custom-designed software. The effect of recombinant STC-1 (0.5 mg/mL) on IOP was evaluated in wild-type mice. Tissue morphology was evaluated by light and transmission electron microscopy. Results: Increased STC-1 mRNA (4.0- to 25.2-fold) and protein expression (1.9- to 5.1-fold) was observed within 12 hours following latanoprost treatment. Latanoprost reduced IOP in wild-type mice (22.0% ± 1.9%), but had no effect on STC-1-/- mice (0.5% ± 0.7%). In contrast, Y27632 reduced IOP in both wild-type (12.5% ± 1.2%) and in STC-1-/- mice (13.1% ± 2.8%). Human anterior segments treated with STC-1 (500 ng/mL) showed an increase in outflow facility (0.15 ± 0.03 to 0.27 ± 0.09 µL/min/mm Hg) while no change was observed in paired vehicle-treated controls. Recombinant STC-1 reduced IOP in wild-type mice by 15.2% ± 3.0%. No observable morphologic changes were identified between treatment groups when evaluated by microscopy. Conclusions: Latanoprost-induced reduction of IOP is mediated through the downstream signaling molecule STC-1. When used by itself, STC-1 exhibits ocular hypotensive properties.
[Mh] Termos MeSH primário: Anti-Hipertensivos/farmacologia
Glicoproteínas/genética
Pressão Intraocular/efeitos dos fármacos
Prostaglandinas F Sintéticas/farmacologia
Transdução de Sinais/fisiologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Amidas/farmacologia
Animais
Segmento Anterior do Olho/citologia
Segmento Anterior do Olho/efeitos dos fármacos
Western Blotting
Linhagem Celular
Regulação da Expressão Gênica/fisiologia
Seres Humanos
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Microscopia Eletrônica de Transmissão
Meia-Idade
Hipotensão Ocular/tratamento farmacológico
Piridinas/farmacologia
RNA Mensageiro/genética
Reação em Cadeia da Polimerase em Tempo Real
Tonometria Ocular
Quinases Associadas a rho/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amides); 0 (Antihypertensive Agents); 0 (Glycoproteins); 0 (Prostaglandins F, Synthetic); 0 (Pyridines); 0 (RNA, Messenger); 138381-45-0 (Y 27632); 6Z5B6HVF6O (latanoprost); 76687-96-2 (teleocalcin); EC 2.7.11.1 (rho-Associated Kinases)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170525
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.16-21004


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[PMID]:28380098
[Au] Autor:Perez CI; Oportus MJ; Mellado F; Valenzuela F; Cartes C; López-Ponce D; Salinas-Toro D; López-Solís R; Traipe L
[Ad] Endereço:Fundación Oftalmológica los Andes, Vitacura, Santiago de Chile.
[Ti] Título:Algorithm approach for revision surgery following late-onset bleb complications after trabeculectomy: long-term follow-up.
[So] Source:Arq Bras Oftalmol;80(1):25-29, 2017 Jan-Feb.
[Is] ISSN:1678-2925
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Purpose:: The aim of this study was to introduce a reproducible algorithm for the surgical management of late-onset (>2 months) bleb complications after trabeculectomy with mitomycin C. Methods:: We performed a retrospective review of eyes treated using a reproducible algorithm approach by a single surgeon for the surgical management of late-onset bleb complications from July 2006 to April 2014. Exclusion criteria were bleb revision with less than 3 months of follow-up or bleb revision combined with other glaucoma procedures at the time of surgery. Success was evaluated using the Kaplan-Meier survival method and defined as achieving all of the following criteria: primary surgery indication resolved, no additional surgery required for decreasing the intraocular pressure (IOP), and IOP of ≥6 mmHg and ≤18 mmHg. Results:: Twenty-three eyes from 20 patients were evaluated. Indications for bleb revision were hypotonic maculopathy (47.8%), bleb leak (30.4%), and dysesthetic bleb (21.7%). The overall primary outcome success rate calculated using the Kaplan-Meier survival method was 65.2% at 48 months. When the IOP target was changed to ≤15 mmHg, the bleb survival rate was 47.8% at 48 months. At the most recent postoperative visit, 95.7% of eyes had an IOP of ≤15 mmHg and 56.5% were being treated with an average of one medication per eye. One eye (4.3%) required a second bleb revision for persistent hypotony and two eyes required glaucoma surgery to reduce IOP during follow-up. Conclusions:: An algorithm approach for the surgical management of late-onset bleb complications with a success rate similar to those reported in specialized literature is proposed. Randomized trials are needed to confirm the best surgical approach.
[Mh] Termos MeSH primário: Algoritmos
Vesícula/cirurgia
Glaucoma/cirurgia
Complicações Pós-Operatórias/cirurgia
Reoperação
Trabeculectomia/efeitos adversos
[Mh] Termos MeSH secundário: Vesícula/etiologia
Reagentes para Ligações Cruzadas/uso terapêutico
Feminino
Seguimentos
Seres Humanos
Pressão Intraocular
Estimativa de Kaplan-Meier
Masculino
Meia-Idade
Mitomicina/uso terapêutico
Hipotensão Ocular/etiologia
Hipotensão Ocular/cirurgia
Complicações Pós-Operatórias/tratamento farmacológico
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cross-Linking Reagents); 50SG953SK6 (Mitomycin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE


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[PMID]:28263262
[Au] Autor:Heisler M; Quong WL; Lee S; Han S; Beg MF; Sarunic MV; Mackenzie PJ
[Ad] Endereço:*School of Engineering Science, Simon Fraser University, Burnaby †Faculty of Medicine ‡Faculty of Applied Science §Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada.
[Ti] Título:Anterior Segment Optical Coherence Tomography for Targeted Transconjunctival Suture Placement in Overfiltering Trabeculectomy Blebs.
[So] Source:J Glaucoma;26(5):486-490, 2017 May.
[Is] ISSN:1536-481X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To demonstrate the utility of swept-source anterior segment optical coherence tomography (SS-AS-OCT) in guiding placement of transconjunctival sutures in hypotonous patients after a trabeculectomy. PATIENTS AND METHODS: This is a longitudinal case series of 10 eyes from 10 patients who required transconjunctival sutures after a trabeculectomy. SS-AS-OCT was used to aid in the placement of the sutures to improve the function of the overfiltering bleb. RESULTS: SS-AS-OCT reliably identified localized areas of overfiltering, allowing for targeted suture placement in 8 eyes. The 2 eyes in which localized areas of overfiltering were not found required further surgical intervention. CONCLUSIONS: SS-AS-OCT enhances transconjunctival suturing for overfiltering blebs when focal fluid accumulation is visualized.
[Mh] Termos MeSH primário: Segmento Anterior do Olho
Túnica Conjuntiva/cirurgia
Hipotensão Ocular/cirurgia
Técnicas de Sutura
Tomografia de Coerência Óptica/métodos
Trabeculectomia/efeitos adversos
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Glaucoma de Ângulo Aberto/cirurgia
Seres Humanos
Pressão Intraocular/fisiologia
Masculino
Meia-Idade
Hipotensão Ocular/etiologia
Hipotensão Ocular/fisiopatologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE
[do] DOI:10.1097/IJG.0000000000000656



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