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[PMID]:29261750
[Au] Autor:Nishi T; Ueda T; Mizusawa Y; Semba K; Shinomiya K; Mitamura Y; Sakamoto T; Ogata N
[Ad] Endereço:Department of Ophthalmology, Nara Medical University, Nara, Japan.
[Ti] Título:Effect of optical correction on subfoveal choroidal thickness in children with anisohypermetropic amblyopia.
[So] Source:PLoS One;12(12):e0189735, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to determine the effect of optical correction on the best-corrected visual acuity (BCVA) and subfoveal choroidal thickness (CT) in the eyes of children with anisohypermetropic amblyopia. Twenty-four anisohypermetropic amblyopic eyes and their fellow eyes of 24 patients and twenty-three eyes of 23 age-matched control children were studied. After one year of optical correction, the BCVA in the anisohypermetropic amblyopic eyes was significantly improved. Before the treatment, the mean subfoveal CT in the amblyopic eyes was 351.9 ± 59.4 µm which was significantly thicker than that of control eyes at 302.4 ± 63.2 µm. After the treatment, the amount of change in the subfoveal CT in the amblyopic and fellow eyes was greater than that in the control eyes. The amblyopic and fellow eyes with thicker choroids had a greater thinning of the choroid whereas eyes with thinner choroids had a greater thickening of the choroid. We conclude that wearing corrective lenses improves the visual acuity, and induces changes of the subfoveal CT in eyes with anisohypermetropic amblyopia.
[Mh] Termos MeSH primário: Ambliopia/complicações
Ambliopia/patologia
Anisometropia/complicações
Anisometropia/patologia
Corioide/patologia
Fóvea Central/patologia
[Mh] Termos MeSH secundário: Ambliopia/fisiopatologia
Anisometropia/fisiopatologia
Estudos de Casos e Controles
Criança
Pré-Escolar
Corioide/fisiopatologia
Demografia
Feminino
Fóvea Central/fisiopatologia
Seres Humanos
Masculino
Tomografia de Coerência Óptica
Acuidade Visual
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189735


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[PMID]:29178892
[Au] Autor:White RJ; Wang Y; Tang P; Montezuma SR
[Ad] Endereço:Department of Ophthalmology and Visual Neurosciences, University of Minnesota, 420 Delaware St. SE, MMC 493, Minneapolis, MN, 55455-0501, USA.
[Ti] Título:Knobloch syndrome associated with Polymicrogyria and early onset of retinal detachment: two case reports.
[So] Source:BMC Ophthalmol;17(1):214, 2017 Nov 25.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Knobloch Syndrome (KS) is a rare congenital syndrome characterized by occipital skull defects and vitreoretinal degeneration. Retinal detachment (RD) often occurs at the end of the first decade of life or later. Aside from occipital skull defects, central nervous system abnormalities are uncommon. CASE PRESENTATIONS: We report on two siblings with KS. The first, a seven month old male, presented with nystagmus and was found to have a serous RD and a tessellated retinal appearance. His sister had a history of multiple visual abnormalities and had a similar retinal appearance although no signs of RD, but retina staphylomas. Genetic testing performed on both siblings showed a mutation in COL18A1, diagnostic of KS. MRI of both siblings demonstrated polymicrogyria but did not show occipital defects. CONCLUSIONS: Although several families with KS have been described previously, our case is noteworthy for several reasons. The RD observed in our first patient occurred at an early age, and we find evidence of only one patient with KS who had an RD identified at an earlier age. The findings of polymicrogyria are not characteristic of KS, and we found only a few previous reports of this association. Additionally, we review potential treatment options for this condition.
[Mh] Termos MeSH primário: Encefalocele/complicações
Polimicrogiria/etiologia
Descolamento Retiniano/congênito
Descolamento Retiniano/etiologia
[Mh] Termos MeSH secundário: Adolescente
Anisometropia/etiologia
Feminino
Seres Humanos
Lactente
Masculino
Miopia Degenerativa/etiologia
Descolamento Retiniano/complicações
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-017-0615-z


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[PMID]:28953639
[Au] Autor:Yang C; Li X; Zhang G; Lan J; Zhang Y; Chu H; Li J; Xie W; Wang S; Yan L; Zeng J
[Ad] Endereço:aDepartment of Ophthalmology, Guangdong Eye Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences bHealth Management Center, Guangdong General Hospital, Guangdong Academy of Medical Sciences cNational Engineering Research Center for Healthcare Devices, Guangzhou, China.
[Ti] Título:Comparison of perceptual eye positions among patients with different degrees of anisometropia.
[So] Source:Medicine (Baltimore);96(39):e8119, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study is to compare the perceptual eye positions (PEPs) among patients with different degrees of anisometropia.A total of 157 patients were recruited into this retrospective study. A detailed ophthalmic examination was conducted on each patient. The degree of refractive errors in the presence of astigmatism was converted into the degree of spherical equivalent (SE). Patients were divided into 3 groups according to the interocular SE difference: severe anisometropia group with interocular SE difference ≥2.50D, mild anisometropia group with interocular SE difference ≥1.00D and <2.50D, and non-anisometropia group with interocular SE difference <1.00D. The vertical and horizontal PEP were measured by a computer-controlled perceptual examination evaluation system. The results obtained from the 3 groups were compared and analyzed.A total of 157 patients were enrolled including 32 patients in the severe anisometropia group, 37 patients in the mild anisometropia group, and 88 patients in the non-anisometropia group. The quartiles of vertical PEP pixels were as follows: 7.50 (5.00, 16.75) in the severe anisometropia group, 5.00 (2.00, 7.50) in the mild anisometropia group, and 5.00 (3.00, 9.00) in the non-anisometropia group, respectively. The vertical PEP pixel was much higher in the severe anisometropia group than that in the other two groups (P < .05). The quartiles of horizontal PEP pixels were as follows: 27.50 (10.75, 67.50) in the severe anisometropia group, 17.00 (7.00, 54.50) in the mild anisometropia group, and 21.50 (11.00, 60.75) in the non-anisometropia group. There were no statistically significant differences among the 3 groups (P > .05).There was an obvious deviation of vertical PEP in patients with anisometropia ≥2.50D, indicating that the instability of vertical PEP might be associated with the development of severe anisometropia.
[Mh] Termos MeSH primário: Anisometropia/psicologia
Propriocepção
[Mh] Termos MeSH secundário: Adolescente
Astigmatismo/psicologia
Estudos de Casos e Controles
Olho
Feminino
Seres Humanos
Masculino
Estudos Retrospectivos
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008119


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[PMID]:28873168
[Au] Autor:Grossman DC; Curry SJ; Owens DK; Barry MJ; Davidson KW; Doubeni CA; Epling JW; Kemper AR; Krist AH; Kurth AE; Landefeld CS; Mangione CM; Phipps MG; Silverstein M; Simon MA; Tseng CW; US Preventive Services Task Force
[Ad] Endereço:Kaiser Permanente Washington Health Research Institute, Seattle.
[Ti] Título:Vision Screening in Children Aged 6 Months to 5 Years: US Preventive Services Task Force Recommendation Statement.
[So] Source:JAMA;318(9):836-844, 2017 Sep 05.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: One of the most important causes of vision abnormalities in children is amblyopia (also known as "lazy eye"). Amblyopia is an alteration in the visual neural pathway in a child's developing brain that can lead to permanent vision loss in the affected eye. Among children younger than 6 years, 1% to 6% have amblyopia or its risk factors (strabismus, anisometropia, or both). Early identification of vision abnormalities could prevent the development of amblyopia. Subpopulation Considerations: Studies show that screening rates among children vary by race/ethnicity and family income. Data based on parent reports from 2009-2010 indicated identical screening rates among black non-Hispanic children and white non-Hispanic children (80.7%); however, Hispanic children were less likely than non-Hispanic children to report vision screening (69.8%). Children whose families earned 200% or more above the federal poverty level were more likely to report vision screening than families with lower incomes. Objective: To update the 2011 US Preventive Services Task Force (USPSTF) recommendation on screening for amblyopia and its risk factors in children. Evidence Review: The USPSTF reviewed the evidence on the accuracy of vision screening tests and the benefits and harms of vision screening and treatment. Surgical interventions were considered to be out of scope for this review. Findings: Treatment of amblyopia is associated with moderate improvements in visual acuity in children aged 3 to 5 years, which are likely to result in permanent improvements in vision throughout life. The USPSTF concluded that the benefits are moderate because untreated amblyopia results in permanent, uncorrectable vision loss, and the benefits of screening and treatment potentially can be experienced over a child's lifetime. The USPSTF found adequate evidence to bound the potential harms of treatment (ie, higher false-positive rates in low-prevalence populations) as small. Therefore, the USPSTF concluded with moderate certainty that the overall net benefit is moderate for children aged 3 to 5 years. Conclusions and Recommendations: The USPSTF recommends vision screening at least once in all children aged 3 to 5 years to detect amblyopia or its risk factors. (B recommendation) The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of vision screening in children younger than 3 years. (I statement).
[Mh] Termos MeSH primário: Ambliopia/diagnóstico
Seleção Visual
[Mh] Termos MeSH secundário: Comitês Consultivos
Anisometropia/diagnóstico
Pré-Escolar
Reações Falso-Positivas
Feminino
Hispano-Americanos
Seres Humanos
Lactente
Masculino
Programas de Rastreamento
Medição de Risco
Fatores de Risco
Estrabismo/diagnóstico
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; PRACTICE GUIDELINE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.11260


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[PMID]:28774525
[Au] Autor:Eissa SA; El-Deeb MW; Hendawi MS
[Ad] Endereço:Ophthalmology, Cairo University, and Ophthalmology and Refractive Surgery, Magrabi Hospital, Khamis Mushait, Kingdom of Saudi Arabia; Ophthalmology Department, Kasr Al Ainy, Cairo University, Egypt.
[Ti] Título:V4B implantable collamer lens versus Intacs corneal rings to manage anisometropic myopic amblyopia in children.
[So] Source:Can J Ophthalmol;52(4):409-415, 2017 Aug.
[Is] ISSN:1715-3360
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To compare the safety and efficacy of phakic intraocular lens (PIOL) versus intrastromal corneal ring segments (Intacs), for correcting high myopic anisometropia in amblyopic children. DESIGN: Nonrandomized prospective multi-center study. PARTICIPANTS: Thirty children, aged between 4 and 12 years, with unilateral high myopic anisometropic amblyopia were included in this study. METHODS: Patients who were prospectively subdivided into group A, with mean preoperative manifest refraction spherical equivalent (MRSE) of -12.96 ± 4.17 D, underwent unilateral phakic posterior chamber intraocular lens implantation. Patients with mean preoperative MRSE of -8.60 ± 1.16 D in group B were treated by Intacs corneal rings. Pre- and postoperative visual acuity, ocular examination, stereoacuity, axial biometry measurements, cycloplegic refraction, and endothelial cell counts were performed in all patients. RESULTS: Group A revealed prevention of amblyopia with improvement in spectacle-corrected distance visual acuity, where 4-6 lines were achieved in 77% of children, 2-3 lines in 4%, and just 0-1 lines restricted to 19% of children. Improvement in stereoacuity was noted in 93.33% of group A cases, whereas group B showed fewer cases of successfully improved vision, with 4-6 lines in 70% of children, 2-3 lines in 3%, and just 0-1 lines restricted to 27% of children. Improvement in stereoacuity was noted in 86.66% of cases. Two cases of cataract and 1 case of glaucoma with 1 case of uveitis were noted in the implantable contact lens (ICL) group. CONCLUSIONS: Posterior chamber PIOLs or Intacs may provide a safe alternative in treating anisometropic myopic patients. Intacs implantation is safer with fewer complications than ICL. However, ICL implantation is advantageous over the corneal ring segment procedure owing to the wide range of errors to correct.
[Mh] Termos MeSH primário: Ambliopia/cirurgia
Anisometropia/cirurgia
Córnea/cirurgia
Implante de Lente Intraocular/métodos
Miopia/cirurgia
Lentes Intraoculares Fácicas
Refração Ocular/fisiologia
[Mh] Termos MeSH secundário: Ambliopia/complicações
Ambliopia/fisiopatologia
Anisometropia/complicações
Anisometropia/fisiopatologia
Criança
Pré-Escolar
Feminino
Seguimentos
Seres Humanos
Masculino
Miopia/complicações
Miopia/fisiopatologia
Estudos Prospectivos
Desenho de Prótese
Resultado do Tratamento
Acuidade Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE


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[PMID]:28614238
[Au] Autor:Feng L; Zhou D; Zhang Z; He L; Liu Y; Yang Y
[Ad] Endereço:aEye Center, The Second Affiliated Hospital of Zhejiang University School of Medicine bDepartment of General Surgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou cBio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University dInstitutes of Biomedical Sciences, Fudan University eKey Laboratory of Molecular Medicine, The Ministry of Education, Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai, PR China.
[Ti] Título:Exome sequencing identifies a novel UNC5D mutation in a severe myopic anisometropia family: A case report.
[So] Source:Medicine (Baltimore);96(24):e7138, 2017 Jun.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Severe myopic anisometropia has been identified to have heritability, but the pathogenesis of anisometropia still remains obscure. CASE DESCRIPTION: Here, we presented a Chinese severe myopic anisometropia family with 5 members affected. Though using the exome sequencing, we identified a novel mutation in the UNC5D gene (c.1297C>T, p.R433C), which was predicted to have a damage effect on the protein function and kept highly conserved throughout evolution across species. As previously described, the UNC5D gene belongs to the UNC5 protein family and may have functions to regulate neuronal migration, axon guidance, and cell survival. The expression of UNC5D was also co-located at the visual areas of the mouse cortical regions at early postnatal ages. CONCLUSION: Our data provide the first evidence for involvement of UNC5D gene in the severe myopic anisometropia.
[Mh] Termos MeSH primário: Anisometropia/genética
Mutação
Miopia/genética
Receptores de Superfície Celular/genética
[Mh] Termos MeSH secundário: Anisometropia/complicações
Grupo com Ancestrais do Continente Asiático/genética
China
Exoma
Família
Feminino
Seres Humanos
Masculino
Miopia/complicações
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Cell Surface); 0 (UNC5H4 protein, human)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007138


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[PMID]:28576202
[Au] Autor:Nabie R; Andalib D; Amir-Aslanzadeh S; Khojasteh H
[Ad] Endereço:Nikookari Eye Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: r_nabie@yahoo.com.
[Ti] Título:Effect of artificial anisometropia in dominant and nondominant eyes on stereoacuity.
[So] Source:Can J Ophthalmol;52(3):240-242, 2017 Jun.
[Is] ISSN:1715-3360
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate the effect of artificial anisometropia in dominant and nondominant eyes on stereoacuity. METHODS: In this descriptive analytic study, 60 healthy adult volunteers 18-37 years of age (mean age: 25.58 years) without any ocular disease were enrolled at Tabriz Nikookari eye hospital over a 1-year period. Anisometropia (unilateral myopia) was induced by placing trial lenses over the dominant and nondominant eyes in 1-diopter (D) increments ranging from 1 to 3 D. Stereoacuity was measured using the TNO, Randot, and Titmus stereotests and values were converted into Napierian logarithm (ln) and compared between the 2 eyes. RESULTS: Of the 60 adults (25 male and 35 female subjects), the right eye was dominant in 49 (81.7%) of the cases. Stereoacuity levels were reduced proportionately to the degree of anisometropia in all participants. Mean stereoacuity was 4.3, 5.5, and 7.4 ln for dominant eyes and 4.1, 5.4, and 7.3 ln for nondominant eyes using the TNO test by applying 1, 2, and 3 D lenses, respectively (p > 0.05). Corresponding values were 3.5, 4.6, and 6.6 ln for dominant eyes and 3.4, 4.6, and 6.5 ln for nondominant eyes by the circles subcategory of Randot test, respectively (p > 0.05). The scores were 3.8, 4.7, and 6.5 ln for dominant eyes and 3.8, 4.7, and 6.4 ln for nondominant eyes by the circles subcategory of Titmus test, respectively (p > 0.05). CONCLUSION: Artificial anisometropia could reduce stereoacuity. However, ocular dominance has no effect on the amount of stereoacuity reduction.
[Mh] Termos MeSH primário: Anisometropia/fisiopatologia
Percepção de Profundidade/fisiologia
Dominância Ocular/fisiologia
Refração Ocular/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Anisometropia/diagnóstico
Feminino
Seres Humanos
Masculino
Índice de Gravidade de Doença
Testes Visuais
Acuidade Visual
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170604
[St] Status:MEDLINE


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[PMID]:28526552
[Au] Autor:Weakley D; Cotsonis G; Wilson ME; Plager DA; Buckley EG; Lambert SR; Infant Aphakia Treatment Study Group
[Ad] Endereço:Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address: David.Weakley@Childrens.com.
[Ti] Título:Anisometropia at Age 5 Years After Unilateral Intraocular Lens Implantation During Infancy in the Infant Aphakia Treatment Study.
[So] Source:Am J Ophthalmol;180:1-7, 2017 Aug.
[Is] ISSN:1879-1891
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To report the prevalence of anisometropia at age 5 years after unilateral intraocular lens (IOL) implantation in infants. DESIGN: Prospective randomized clinical trial. METHODS: Fifty-seven infants in the Infant Aphakia Treatment Study (IATS) with a unilateral cataract were randomized to IOL implantation with an initial targeted postoperative refractive error of either +8 diopters (D) (infants 28 to <48 days of age) or +6 D (infants 48-210 days of age). Anisometropia was calculated at age 5 years. Six patients were excluded from the analyses. RESULTS: Median age at cataract surgery was 2.2 months (interquartile range [IQR], 1.2, 3.5 months). The mean age at the age 5 years follow-up visit was 5.0 ± 0.1 years (range, 4.9-5.4 years). The median refractive error at the age 5 years visit of the treated eyes was -2.25 D (IQR -5.13, +0.88 D) and of the fellow eyes +1.50 D (IQR +0.88, +2.25). Median anisometropia was -3.50 D (IQR -8.25, -0.88 D); range -19.63 to +2.75 D. Patients with glaucoma in the treated eye (n = 9) had greater anisometropia (glaucoma, median -8.25 D; IQR -11.38, -5.25 D vs no glaucoma median -2.75; IQR -6.38, -0.75 D; P = .005). CONCLUSIONS: The majority of pseudophakic eyes had significant anisometropia at age 5 years. Anisometropia was greater in patients that developed glaucoma. Variability in eye growth and myopic shift continue to make refractive outcomes challenging for IOL implantation during infancy.
[Mh] Termos MeSH primário: Anisometropia/etiologia
Afacia Pós-Catarata/cirurgia
Extração de Catarata
Hiperopia/etiologia
Implante de Lente Intraocular/efeitos adversos
Miopia/etiologia
[Mh] Termos MeSH secundário: Anisometropia/diagnóstico
Pré-Escolar
Feminino
Seguimentos
Glaucoma/etiologia
Glaucoma/fisiopatologia
Seres Humanos
Lactente
Recém-Nascido
Lentes Intraoculares
Masculino
Estudos Prospectivos
Pseudofacia/etiologia
Pseudofacia/fisiopatologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170521
[St] Status:MEDLINE


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[PMID]:28510775
[Au] Autor:Zedan RH; El-Fayoumi D; Awadein A
[Ti] Título:Progression of High Anisometropia in Children.
[So] Source:J Pediatr Ophthalmol Strabismus;54(5):282-286, 2017 Sep 01.
[Is] ISSN:1938-2405
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To investigate the onset and rate of progression of high anisometropia in myopic children younger than 13 years. METHODS: A retrospective study was performed on children with anisometropia younger than 13 years with myopia of more than 4.00 diopters (D) in the more ametropic eye and a difference in spherical equivalent refraction of 4.00 D between both eyes. All children had a complete ophthalmologic examination, including measurement of visual acuity and cycloplegic refraction every 3 to 6 months for at least 5 years. Change in the spherical equivalent and the cylindrical error for both eyes and changes in the difference in spherical equivalent refraction between both eyes were calculated for each patient at each visit. Linear, polynomial, logarithmic, and exponential fitting models were tested for both eyes and for the anisometropic difference between both eyes. The regression line with the greatest R value was considered best fit. RESULTS: Sixty-three patients fulfilled the inclusion criteria. The more ametropic eye grew in a regular fashion during the first 2 years of life, followed by a rapid decrease in the rate of growth to become almost stable after 4 years of age. The increase in myopia best fit a third-degree polynomial (cubic) model (R = 0.98). The less ametropic eye showed only a small increase in myopia during the follow-up period. The anisometropic difference between both eyes increased gradually during the first 2 years, then remained stable. CONCLUSIONS: High anisometropic myopia progresses rapidly in the first few years of life before becoming stable. [J Pediatr Ophthalmol Strabismus. 2017;54(5):282-286.].
[Mh] Termos MeSH primário: Anisometropia/diagnóstico
Miopia/complicações
Refração Ocular/fisiologia
Acuidade Visual
[Mh] Termos MeSH secundário: Anisometropia/etiologia
Anisometropia/fisiopatologia
Criança
Pré-Escolar
Progressão da Doença
Feminino
Seguimentos
Seres Humanos
Lactente
Recém-Nascido
Masculino
Miopia/diagnóstico
Miopia/fisiopatologia
Estudos Retrospectivos
Índice de Gravidade de Doença
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170517
[St] Status:MEDLINE
[do] DOI:10.3928/01913913-20170320-06


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[PMID]:28481050
[Au] Autor:Pärssinen O; Kauppinen M
[Ad] Endereço:Department of Ophthalmology, Central Hospital of Central Finland, Jyväskylä, Finland.
[Ti] Título:Anisometropia of spherical equivalent and astigmatism among myopes: a 23-year follow-up study of prevalence and changes from childhood to adulthood.
[So] Source:Acta Ophthalmol;95(5):518-524, 2017 Aug.
[Is] ISSN:1755-3768
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To study anisometropia of spherical equivalent and astigmatism from the onset of myopia at school age to adulthood. METHODS: A total of 240 myopic schoolchildren (mean age 10.9 years), with no previous spectacles, were recruited during 1983-1984 to a randomized 3-year clinical trial of bifocal treatment of myopia. Examinations with subjective cyclopedic refraction were repeated 3 years later (follow-up 1) for 238 subjects and thereafter at the mean ages of 23.2 (follow-up 2) and 33.9 years (follow-up 3) for 178 and 134 subjects. After exclusions, the 102 subjects who attended all three follow-ups were included in the analyses. Corneal refractive power and astigmatism and anterior chamber depth was measured with Pentacam topography and axial length with IOL master at study end. Prevalence and changes in anisometropia of spherical equivalent (AnisoSE) and astigmatism (AnisoAST) and their relationships with refractive and axial measures were studied. RESULTS: Mean (±SD) of spherical equivalent (SE), AnisoSE and AnisoAST increased from baseline to follow-up end from -1.44 ± 0.57 D to -5.11 ± 2.23 D, from 0.28 ± 0.30 D to 0.68 ± 0.69 D and from 0.14 ± 0.18 D to 0.37 ± 0.36 D, respectively. Prevalence of AnioSE, ≥1 D, increased from 5% to 22.6% throughout follow-up. Higher AnisoSE was associated with SE in the less myopic eye at baseline and at follow-up 1, and with SE in the more myopic eye in follow-ups 2 and 3 in adulthood. At study end, AnisoSE was associated with the interocular difference in axial length (AL) (r = 0.612, p < 0.001) but not with the interocular difference in corneal refraction (CR) (r = -0.122, p = 0.266). In cases of low AnisoSE(≤1.00 D), the negative correlation between the real interocular differences (value of right eye minus value of left eye) in CR and AL (r = -0.427, p < 0.001) decreased the influence of the interocular difference in AL on AnisoSE, causing emmetropization in AnisoSE. The interocular difference in corneal astigmatism was the main factor associated with AnisoAST (r = 0.231, p = 0.020). No significant relationship was found between AnisoAST and level of SE. CONCLUSION: Anisometropia of the spherical equivalent (AnisoSE) increased along with the myopic progression and at study end was mainly associated with the interocular difference in AL. AnisoAST was mainly explained by the interocular difference in corneal astigmatism. In cases with low AnisoSE (≤1.0 D), the interrelationship between CR and AL decreased AnisoSE causing emmetropization in AnisoSE.
[Mh] Termos MeSH primário: Anisometropia/epidemiologia
Astigmatismo/epidemiologia
Óculos
Previsões
Miopia/complicações
Refração Ocular
[Mh] Termos MeSH secundário: Adolescente
Adulto
Anisometropia/etiologia
Anisometropia/fisiopatologia
Astigmatismo/etiologia
Astigmatismo/fisiopatologia
Comprimento Axial do Olho
Criança
Córnea/patologia
Topografia da Córnea
Progressão da Doença
Feminino
Finlândia/epidemiologia
Seguimentos
Seres Humanos
Masculino
Miopia/fisiopatologia
Miopia/terapia
Prevalência
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.1111/aos.13405



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