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  1 / 1831 MEDLINE  
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[PMID]:28470646
[Au] Autor:Seppey C; Wolfensberger TJ
[Ad] Endereço:Jules Gonin Eye Hospital, University of Lausanne, Lausanne, Switzerland.
[Ti] Título:Vitrectomy with Fovea-Sparing Internal Limiting Membrane Peeling for Myopic Foveoschisis.
[Ti] Título:Vitrektomie mit foveaaussparendem Membrana-limitans-interna-Peeling für myope Foveoschisis..
[So] Source:Klin Monbl Augenheilkd;234(4):497-500, 2017 Apr.
[Is] ISSN:1439-3999
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Myopic foveoschisis is a rare form of a tractional maculopathy, which occurs in patients with elevated axial length. The contraction of the posterior hyaloid exerts tangential traction on the retinal surface with a subsequent continuous splitting of the retinal layers. Internal limiting membrane (ILM) peeling has been advocated in foveoschisis, but it has been associated with post-operative macular hole formation. We report on a modified surgical technique, which spares the fovea and may reduce the risk for macular hole formation. Retrospective analysis of 6 patients with myopic foveoschisis. The mean age was 53.8 ± 12.9 years (4M, 2F) and mean myopia was - 18.3 ± 6.5 Dpt. After a 23 g pars plana vitrectomy, the ILM was peeled on the entire macular surface, except in the foveal region lest the thin foveal structures be damaged. All patients received a gas tamponnade with 23 % SF6 and maintained a face down position for 5 days. Mean best-corrected pre-operative visual acuity was 0.87 ± 0.56 logMAR, which increased to 0.60 ± 0.40 logMAR at the end of follow-up. The retinal thickness, as measured by optical coherence tomography, decreased from 799 ± 352 micrometers to 318 ± 60 micrometers at the end of follow-up 7.8 ± 5.7 months. No case developed a macular hole. Vitrectomy with fovea sparing ILM peeling is a promising surgical technique, which results in an improved foveal anatomy and retinal function. Due to the sparing of the fovea, this surgical technique may reduce the risk of macular hole formation in the post-operative period.
[Mh] Termos MeSH primário: Tamponamento Interno/métodos
Membrana Epirretiniana/cirurgia
Fóvea Central/patologia
Miopia/cirurgia
Tratamentos com Preservação do Órgão/métodos
Retinosquise/cirurgia
Vitrectomia/métodos
[Mh] Termos MeSH secundário: Adulto
Terapia Combinada/métodos
Membrana Epirretiniana/patologia
Feminino
Seguimentos
Fóvea Central/lesões
Seres Humanos
Masculino
Meia-Idade
Miopia/diagnóstico
Retinosquise/diagnóstico
Resultado do Tratamento
Acuidade Visual
Vitrectomia/efeitos adversos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1055/s-0043-104429


  2 / 1831 MEDLINE  
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[PMID]:29183292
[Au] Autor:Gao M; Wang Y; Liu W; Liu L; Yan W; Liu J; Liu K; Liu X; Hu Y
[Ad] Endereço:Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.
[Ti] Título:Assessment of macular function in patients with idiopathic Epiretinal membrane by multifocal Electroretinography: correlation with visual acuity and optical coherence tomography.
[So] Source:BMC Ophthalmol;17(1):221, 2017 Nov 28.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This study evaluates the macular function changes in patients with idiopathic macular epiretinal membrane (ERM) by multifocal electroretinography (mfERG) and their correlations with visual acuity and central macular thickness (CMT) by optical coherence tomography (OCT). METHODS: Twenty eyes of 20 patients with ERM underwent OCT and mfERG examinations. The response amplitude densities and implicit times of mfERG were compared to the control fellow eyes. Correlation analyses among visual acuity, central macular thickness and mfERG values in the central two concentric rings were performed. RESULTS: The mfERG P1 response amplitude densities in ring 1-2 and P1 implicit time in ring1 were significantly changed in epiretinal membrane eyes compared with controls (P < 0.05). Multivariate stepwise linear regression analyses showed LogMAR visual acuity was significantly correlated with CMT (P = 0.004), and also with the P1 amplitude density in ring 1 (P = 0.002). CMT showed significant correlation with P1 implicit time in ring 2 (P = 0.013). CONCLUSIONS: The mfERG abnormalities show macular function changes and correlate with visual acuity and central macular thickness in eyes with ERM. In first-order mfERG responses, P1 wave changes may be a sensitive functional measurement for ERM patients.
[Mh] Termos MeSH primário: Membrana Epirretiniana/fisiopatologia
Macula Lutea/fisiopatologia
Acuidade Visual/fisiologia
[Mh] Termos MeSH secundário: Idoso
Eletrorretinografia/métodos
Membrana Epirretiniana/patologia
Feminino
Seres Humanos
Macula Lutea/patologia
Masculino
Meia-Idade
Retina/fisiopatologia
Tomografia de Coerência Óptica/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-017-0621-1


  3 / 1831 MEDLINE  
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[PMID]:29179705
[Au] Autor:Yuan J; Zhang LL; Lu YJ; Han MY; Yu AH; Cai XJ
[Ad] Endereço:Department of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, People's Republic of China.
[Ti] Título:Vitrectomy with internal limiting membrane peeling versus inverted internal limiting membrane flap technique for macular hole-induced retinal detachment: a systematic review of literature and meta-analysis.
[So] Source:BMC Ophthalmol;17(1):219, 2017 Nov 28.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To evaluate the effects on vitrectomy with internal limiting membrane (ILM) peeling versus vitrectomy with inverted internal limiting membrane flap technique for macular hole-induced retinal detachment (MHRD). METHODS: Pubmed, Cochrane Library, and Embase were systematically searched for studies that compared ILM peeling with inverted ILM flap technique for macular hole-induced retinal detachment. The primary outcomes are the rate of retinal reattachment and the rate of macular hole closure 6 months later after initial surgery, the secondary outcome is the postoperative best-corrected visual acuity (BCVA) 6 months later after initial surgery. RESULTS: Four studies that included 98 eyes were selected. All the included studies were retrospective comparative studies. The preoperative best-corrected visual acuity was equal between ILM peeling and inverted ILM flap technique groups. It was indicated that the rate of retinal reattachment (odds ratio (OR) = 0.14, 95% confidence interval (CI):0.03 to 0.69; P = 0.02) and macular hole closure (OR = 0.06, 95% CI:0.02 to 0.19; P < 0.00001) after initial surgery was higher in the group of vitrectomy with inverted ILM flap technique than that in the group of vitrectomy with ILM peeling. However, there was no statistically significant difference in postoperative best-corrected visual acuity (mean difference (MD) 0.18 logarithm of the minimum angle of resolution; 95% CI -0.06 to 0.43 ; P = 0.14) between the two surgery groups. CONCLUSION: Compared with ILM peeling, vitrectomy with inverted ILM flap technique resulted significantly higher of the rate of retinal reattachment and macular hole closure, but seemed does not improve postoperative best-corrected visual acuity.
[Mh] Termos MeSH primário: Membrana Epirretiniana/cirurgia
Descolamento Retiniano/cirurgia
Perfurações Retinianas/cirurgia
Retalhos Cirúrgicos
Vitrectomia/métodos
[Mh] Termos MeSH secundário: Seres Humanos
Descolamento Retiniano/etiologia
Perfurações Retinianas/complicações
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-017-0619-8


  4 / 1831 MEDLINE  
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[PMID]:29049715
[Au] Autor:Obana A; Sasano H; Okazaki S; Otsuki Y; Seto T; Gohto Y
[Ad] Endereço:Department of Ophthalmology, Seirei Hamamatsu General Hospital, Naka-ku, Hamamatsu City, Shizuoka, Japan.
[Ti] Título:Evidence of Carotenoid in Surgically Removed Lamellar Hole-Associated Epiretinal Proliferation.
[So] Source:Invest Ophthalmol Vis Sci;58(12):5157-5163, 2017 Oct 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To determine the constituents and origin of the yellow pigment in surgically removed lamellar hole-associated epiretinal proliferation (LHEP) in patients with lamellar macular hole (LMH). Methods: This prospective case series comprised nine eyes with LMH in patients aged 41 to 83 years. The presence of LHEP was confirmed by preoperative optical coherence tomography; the distribution of macular pigment was observed by two-wavelength fundus autofluorescence technique before and after surgery. The subjects underwent a 25-gauge vitrectomy, and the surgically removed epiretinal membranous tissue was fixed with formalin. The specimens were examined using resonance Raman microscopy, and paraffin sections were stained with antiglial fibrillary acidic protein. Results: Seven cases presented with LHEP, and the presence of yellow pigment was confirmed using an operating microscope. Carotenoid-specific Raman signals with three major Raman peaks could be identified in the specimens with LHEP. These specimens were positive for glial fibrillary acidic protein staining. Using the fundus autofluorescence technique, a central defect in the distribution of the macular pigment was noted in the exact area of the lamellar hole. This type of defect was no longer visible after surgical repair of the lamellar hole. Conclusions: The constituents of the yellow pigment in the removed LHEP were carotenoids that typically originate from the macular xanthophyll pigments at the fovea. Since LHEP is reported to be composed of Müller cells, we hypothesize that xanthophyll carotenoids at the fovea are contained in the Müller cells.
[Mh] Termos MeSH primário: Membrana Epirretiniana/metabolismo
Pigmento Macular/metabolismo
Perfurações Retinianas/metabolismo
Xantofilas/metabolismo
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Biomarcadores/metabolismo
Membrana Epirretiniana/diagnóstico
Membrana Epirretiniana/cirurgia
Feminino
Fundo de Olho
Proteína Glial Fibrilar Ácida/metabolismo
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Perfurações Retinianas/diagnóstico
Perfurações Retinianas/cirurgia
Análise Espectral Raman
Tomografia de Coerência Óptica
Acuidade Visual
Vitrectomia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Glial Fibrillary Acidic Protein); 0 (Macular Pigment); 0 (Xanthophylls)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22347


  5 / 1831 MEDLINE  
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[PMID]:28973331
[Au] Autor:Shiode Y; Morizane Y; Matoba R; Hirano M; Doi S; Toshima S; Takahashi K; Araki R; Kanzaki Y; Hosogi M; Yonezawa T; Yoshida A; Shiraga F
[Ad] Endereço:Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
[Ti] Título:The Role of Inverted Internal Limiting Membrane Flap in Macular Hole Closure.
[So] Source:Invest Ophthalmol Vis Sci;58(11):4847-4855, 2017 Sep 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To investigate the mechanism of macular hole (MH) closure following the inverted internal limiting membrane (ILM) technique. Methods: We performed the inverted ILM flap surgical technique as an experimental MH model in monkeys, and investigated the process of MH closure immunohistochemically. We then investigated the effects of type IV collagen, fibronectin, and laminin, which are constituent proteins of the ILM, on the proliferation and migration of cultivated Müller cells (MIO-M1). We also investigated the expression of neurotrophic factors and basic fibroblast growth factor (bFGF) in human ILM and MIO-M1 cells, and the effect of MIO-M1 migration on the expression of these factors, via immunohistochemical staining and the real-time reverse transcription polymerase chain reaction. Results: Ten days after inverted ILM flap surgery, the MH had closed and proliferating glial fibrillary acidic protein (GFAP)-positive cells surrounded the ILM. Type IV collagen, fibronectin, and laminin all enhanced the proliferation of MIO-M1 cells, and type IV collagen and fibronectin enhanced the migration of MIO-M1 cells. Neurotrophic factors and bFGF were present on the surface of the human ILM, and MIO-M1 cells produced these factors. Neurotrophic factors and bFGF were expressed to a significantly greater extent by migrating MIO-M1 cells than by these cells in their static state. Conclusions: During MH closure, the ILM functioned as a scaffold for the proliferation and migration of Müller cells, and may promote Müller cell activation. Neurotrophic factors and bFGF produced by activated Müller cells and present on the surface of the ILM may contribute to MH closure.
[Mh] Termos MeSH primário: Membrana Epirretiniana/cirurgia
Perfurações Retinianas/cirurgia
Retalhos Cirúrgicos
Vitrectomia/métodos
[Mh] Termos MeSH secundário: Análise de Variância
Animais
Membrana Basal/cirurgia
Movimento Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Células Cultivadas
Colágeno Tipo IV/farmacologia
Modelos Animais de Doenças
Células Ependimogliais/efeitos dos fármacos
Células Ependimogliais/metabolismo
Membrana Epirretiniana/metabolismo
Fator 2 de Crescimento de Fibroblastos/metabolismo
Fibronectinas/farmacologia
Laminina/farmacologia
Macaca fascicularis
Masculino
Fatores de Crescimento Neural/metabolismo
Fatores de Crescimento Neural/farmacologia
Perfurações Retinianas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Collagen Type IV); 0 (Fibronectins); 0 (Laminin); 0 (Nerve Growth Factors); 103107-01-3 (Fibroblast Growth Factor 2)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-21756


  6 / 1831 MEDLINE  
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[PMID]:28913997
[Au] Autor:Kim S; Kim MK; Wee WR
[Ad] Endereço:Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
[Ti] Título:Additive Effect of Oral Steroid with Topical Nonsteroidal Anti-inflammatory Drug for Preventing Cystoid Macular Edema after Cataract Surgery in Patients with Epiretinal Membrane.
[So] Source:Korean J Ophthalmol;31(5):394-401, 2017 Oct.
[Is] ISSN:2092-9382
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To investigate the additive effect of oral steroid with topical nonsteroidal anti-inflammatory drug (NSAID) on cystoid macular edema (CME) in patients with epiretinal membrane (ERM) after cataract surgery. METHODS: Medical records of subjects who underwent uneventful cataract surgery (n = 1,349) were retrospectively reviewed; among these patients, those with pre-existing ERM (n = 81) were included. Patients were divided into two groups: one group had postoperative administration of oral steroid for 1 week (n = 45) and the other group did not have oral steroid administration (n = 36). Changes in macular thickness and incidence of CME were compared in both groups. Topical NSAIDs were administered in both groups for 1 month postoperatively. Definite CME and probable CME were defined by changes in retinal contour with or without cystoid changes. Change in central macular thickness of more than three standard deviations (≥90.17 µm) was defined as possible CME. Macular thickness was measured at 1 month after the operation by optical coherence tomography. RESULTS: The incidence of definite, probable, and possible CME were 2.22%, 4.44%, and 8.89% with the use of steroid and 2.78%, 5.56%, and 8.33% without steroid, respectively (p = 0.694, p = 0.603, and p = 0.625), and regardless of treatment group, the incidences in these patients were higher compared to incidences in whole subjects (1.26%, 2.30%, and 4.32%; p = 0.048, p = 0.032, and p = 0.038, respectively). The differences in macular thickness were not statistically different between the two groups. Average changes of central foveal thickness in 3 mm and 6 mm zone were 29.29 µm, 35.93 µm, and 38.02 µm with the use of steroid and 32.25 µm, 44.08 µm, and 45.39 µm without steroid (p = 0.747, p = 0.148, and p = 0.077, respectively). CONCLUSIONS: This study suggests that administration of oral steroid may not have a synergistic effect in reduction of CME and retinal thickness in patients with pre-existing ERM after cataract surgery, when topical NSAIDs are applied.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/administração & dosagem
Catarata/complicações
Membrana Epirretiniana/complicações
Glucocorticoides/administração & dosagem
Edema Macular/prevenção & controle
Complicações Pós-Operatórias/prevenção & controle
Transtornos Relacionados ao Uso de Substâncias/etiologia
[Mh] Termos MeSH secundário: Administração Oral
Administração Tópica
Idoso
Extração de Catarata/efeitos adversos
Quimioterapia Combinada
Membrana Epirretiniana/diagnóstico
Feminino
Seres Humanos
Edema Macular/diagnóstico
Edema Macular/etiologia
Masculino
Complicações Pós-Operatórias/diagnóstico
Estudos Retrospectivos
Tomografia de Coerência Óptica
Acuidade Visual
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Glucocorticoids)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE
[do] DOI:10.3341/kjo.2016.0109


  7 / 1831 MEDLINE  
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[PMID]:28810041
[Au] Autor:Tian T; Chen C; Jin H; Zhang Q; Xu Y; Wang S; Zhang X; Zhao P
[Ti] Título:Morphologic and Postoperative Fixation Characteristics of the Macular Epiretinal Membrane in Young Patients Undergoing Surgery.
[So] Source:Ophthalmic Surg Lasers Imaging Retina;48(8):655-662, 2017 Aug 01.
[Is] ISSN:2325-8179
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVE: To describe morphologic characteristics, surgical outcomes, postoperative preferred retinal loci (PRL), and fixation stability of epiretinal membranes (ERMs) in young patients. PATIENTS AND METHODS: This retrospective study analyzed 43 eyes of 41 young patients (age range: 0.8 years to 28 years) with ERMs, which were divided into two groups: secondary ERMs (SERMs; n = 28) and idiopathic ERMs (IERMs; n = 13). All 43 eyes underwent 25-gauge vitrectomy and membrane peeling. Spectral-domain optical coherence tomography scans and microperimetry were used to analyze morphologic and fixation characteristics, respectively. RESULTS: Premacular fibrosis was more common in SERMs group (P = .006). SERMs were also associated with less external limiting membrane (ELM) (P = .008) and ellipsoid zone visibility (P = .008) compared with IERMs. Best-corrected visual acuity (BCVA) improved in 20 eyes (69%) with SERMs (P = .005) and in 12 eyes (86%) with IERMs (P = .13). From the analysis of the postoperative fixation characteristics, there was a linear correlation between visual acuity and fixation stability (R = 0.495). CONCLUSION: BCVA improved significantly in young patients with ERM, even in cases with a severely disrupted ELM and ellipsoid zone. More attention should be paid to the postoperative fixation location and stability. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:655-662.].
[Mh] Termos MeSH primário: Membrana Epirretiniana/cirurgia
Fixação Ocular/fisiologia
Macula Lutea/cirurgia
Tomografia de Coerência Óptica/métodos
Acuidade Visual
Vitrectomia/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Pré-Escolar
Membrana Epirretiniana/diagnóstico
Membrana Epirretiniana/fisiopatologia
Feminino
Seres Humanos
Lactente
Recém-Nascido
Macula Lutea/patologia
Masculino
Período Pós-Operatório
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170816
[St] Status:MEDLINE
[do] DOI:10.3928/23258160-20170802-08


  8 / 1831 MEDLINE  
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[PMID]:28777835
[Au] Autor:Amarnani D; Machuca-Parra AI; Wong LL; Marko CK; Stefater JA; Stryjewski TP; Eliott D; Arboleda-Velasquez JF; Kim LA
[Ad] Endereço:Schepens Eye Research Institute of Massachusetts Eye and Ear, Boston, Massachusetts, United States.
[Ti] Título:Effect of Methotrexate on an In Vitro Patient-Derived Model of Proliferative Vitreoretinopathy.
[So] Source:Invest Ophthalmol Vis Sci;58(10):3940-3949, 2017 Aug 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: The purpose of this study was to develop a method for isolating, culturing, and characterizing cells from patient-derived membranes in proliferative vitreoretinopathy (PVR) to be used for drug testing. Methods: PVR membranes were obtained from six patients with grade C PVR. Membrane fragments were analyzed by gross evaluation, fixed for immunohistologic studies to establish cell identity, or digested with collagenase II to obtain single cell suspensions for culture. PVR-derived primary cultures were used to examine the effects of methotrexate (MTX) on proliferation, migration, and cell death. Results: Gross analysis of PVR membranes showed presence of pigmented cells, indicative of retinal pigment epithelial cells. Immunohistochemistry identified cells expressing α-smooth muscle actin, glial fibrillary acidic protein, Bestrophin-1, and F4/80, suggesting the presence of multiple cell types in PVR. Robust PVR primary cultures (C-PVR) were successfully obtained from human membranes, and these cells retained the expression of cell identity markers in culture. C-PVR cultures formed membranes and band-like structures in culture reminiscent of the human condition. MTX significantly reduced the proliferation and band formation of C-PVR, whereas it had no significant effect on cell migration. MTX also induced regulated cell death within C-PVR as assessed by increased expression of caspase-3/7. Conclusions: PVR cells obtained from human membranes can be successfully isolated, cultured, and profiled in vitro. Using these primary cultures, we identified MTX as capable of significantly reducing growth and inducing cell death of PVR cells in vitro.
[Mh] Termos MeSH primário: Membrana Epirretiniana/tratamento farmacológico
Imunossupressores/farmacologia
Metotrexato/farmacologia
Epitélio Pigmentado da Retina/efeitos dos fármacos
Vitreorretinopatia Proliferativa/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Idoso
Apoptose/efeitos dos fármacos
Biomarcadores/metabolismo
Técnicas de Cultura de Células
Movimento Celular/fisiologia
Proliferação Celular/fisiologia
Separação Celular
Membrana Epirretiniana/metabolismo
Membrana Epirretiniana/patologia
Proteínas da Matriz Extracelular/metabolismo
Feminino
Técnica Indireta de Fluorescência para Anticorpo
Seres Humanos
Masculino
Meia-Idade
Modelos Biológicos
Fenótipo
Descolamento Retiniano/complicações
Epitélio Pigmentado da Retina/metabolismo
Epitélio Pigmentado da Retina/patologia
Fator de Necrose Tumoral alfa/farmacologia
Vitreorretinopatia Proliferativa/etiologia
Vitreorretinopatia Proliferativa/metabolismo
Vitreorretinopatia Proliferativa/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Extracellular Matrix Proteins); 0 (Immunosuppressive Agents); 0 (Tumor Necrosis Factor-alpha); YL5FZ2Y5U1 (Methotrexate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170811
[Lr] Data última revisão:
170811
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.16-20912


  9 / 1831 MEDLINE  
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[PMID]:28704441
[Au] Autor:Nishikawa Y; Morishita S; Horie T; Fukumoto M; Sato T; Kida T; Oku H; Sugasawa J; Ikeda T; Nakamura K
[Ad] Endereço:Department of Ophthalmology, Osaka Medical College, Takatsuki-City, Osaka, Japan.
[Ti] Título:A comparison of sex steroid concentration levels in the vitreous and serum of patients with vitreoretinal diseases.
[So] Source:PLoS One;12(7):e0180933, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to compare steroid hormone concentration levels in the vitreous and serum of vitreoretinal disease patients to elucidate the possibility of neurosteroid production in the retina. Serum and vitreous samples were collected from vitrectomy patients, and estradiol (E2) and testosterone (T) concentrations were measured using electro-chemiluminescence immunoassay. We measured E2 in epiretinal membrane (ERM, n = 14), macular hole (MH, n = 18), proliferative diabetic retinopathy (PDR, n = 20), and retinal detachment (RD, n = 19) cases, and T in ERM (n = 14), MH (n = 17), PDR (n = 13), and RD (n = 17) cases. No statistically significant age differences existed among the groups. Mean respective E2 concentrations (pg/ml) in the male/female vitreous were ERM: 6.67±4.04/18.82±7.10, MH: 10.3±7.02/17.00±4.8, PDR: 4.2±3.05/15.83±3.46, and RD: 10.00±4.58/16.06±4.57, while those in serum were ERM: 31.67±5.51/5.82±1.08, MH: 21.00±8.89/7.53±3.2, PDR: 29.20±7.07/12.75±10.62, and RD: 24.33±6.51/7.5±4.42. E2 concentrations were significantly higher (P<0.001) in the male serum than vitreous, yet significantly higher in the female vitreous than serum. Mean respective T concentrations (ng/ml) in the male/female vitreous were ERM: 0.15±0.03/0.15±0.01, MH: 0.15±0.01/0.15±0.01, PDR: 0.15±0.03/0.16±0.12, and RD: 0.14±0.01/0.17±0.08, while those in serum were ERM: 4.54±1.46/0.16±0.01, MH: 8.04±2.29/0.16±0.10, PDR: 5.14±1.54/0.22±0.11, and RD: 3.24±0.75/0.17±0.10. T concentrations were high in the male serum, yet extremely low in the male and female vitreous and female serum. High concentrations of E2 were found in the vitreous, and women, in particular, exhibited significantly higher concentrations in the vitreous than in the serum. This finding suggests the possibility that in vitreoretinal disease cases, the synthesis of E2 is increased locally only in female eyes.
[Mh] Termos MeSH primário: Retinopatia Diabética/cirurgia
Membrana Epirretiniana/cirurgia
Hormônios Esteroides Gonadais/análise
Descolamento Retiniano/cirurgia
Perfurações Retinianas/cirurgia
Corpo Vítreo/metabolismo
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Retinopatia Diabética/metabolismo
Membrana Epirretiniana/metabolismo
Feminino
Hormônios Esteroides Gonadais/sangue
Hormônios Esteroides Gonadais/metabolismo
Seres Humanos
Masculino
Meia-Idade
Descolamento Retiniano/metabolismo
Perfurações Retinianas/metabolismo
Caracteres Sexuais
Vitrectomia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gonadal Steroid Hormones)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180933


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[PMID]:28699324
[Au] Autor:Hamoudi H; Christensen UC; La Cour M
[Ad] Endereço:Department of Ophthalmology, Rigshospitalet-Glostrup, Copenhagen University Hospital, Glostrup, Denmark.
[Ti] Título:Corneal endothelial cell loss and corneal biomechanical characteristics after two-step sequential or combined phaco-vitrectomy surgery for idiopathic epiretinal membrane.
[So] Source:Acta Ophthalmol;95(5):493-497, 2017 Aug.
[Is] ISSN:1755-3768
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To assess the impact of sequential and combined surgery [cataract surgery and 23-gauge pars plana vitrectomy (PPV) with peeling] on corneal endothelium cell density (CED) and corneal biomechanical characteristics. METHODS: Phakic eyes with epiretinal membrane (ERM) were prospectively allocated to (i) cataract surgery and subsequent PPV (CAT group), (ii) PPV and subsequent cataract surgery (VIT group) or (iii) phacovitrectomy (COMBI group). Eyes were examined at baseline, 1 month after each surgery, and at 3 and 12 months follow-up. Corneal endothelium cell density (CED) was assessed with non-contact specular microscopy. Pachymetry [central cornea thickness (CCT)], keratometry and cornea volume (CV) were measured with Pentacam Scheimpflug camera. Primary outcome was change in CED after 12 months; secondary outcomes were changes in CCT and CV after 12 months. RESULTS: Sixty-two eyes were enrolled and allocated to the three groups. The mean preoperative CED was 2776, 2794 and 2653 cells/mm which decreased significantly at 12 months by 15.3, 20.0 and 19.3% in the CAT, VIT and COMBI group. There was no significant difference in percentage cell loss between the groups at final follow-up. The CED decreased significantly after cataract surgery, but was unaffected by PPV. Central cornea thickness (CCT) increased by 10 µm (p = 0.005) and CV by 1.38 mm (2.3%, p < 0.001) in the COMBI group. There were no significant differences in CCT or CV between the groups at final follow-up. CONCLUSION: Combined and sequential surgery in ERM leads to a small decrease in CED. Performing cataract surgery before, after or in combination with vitrectomy did not make any significant difference with respect to final CED, CCT or CV.
[Mh] Termos MeSH primário: Catarata/complicações
Córnea/fisiopatologia
Perda de Células Endoteliais da Córnea/etiologia
Membrana Epirretiniana/cirurgia
Facoemulsificação/efeitos adversos
Complicações Pós-Operatórias
Vitrectomia/efeitos adversos
[Mh] Termos MeSH secundário: Fenômenos Biomecânicos
Córnea/patologia
Perda de Células Endoteliais da Córnea/diagnóstico
Perda de Células Endoteliais da Córnea/fisiopatologia
Membrana Epirretiniana/complicações
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Fatores de Tempo
Acuidade Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1111/aos.13474



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