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[PMID]:29183023
[Au] Autor:Demirel S; Degirmenci MFK; Bilici S; Yanik Ö; Batioglu F; Özmert E; Alp N
[Ad] Endereço:Department of Ophthalmology, Ankara University Faculty of Medicine, Ankara, Turkey.
[Ti] Título:The Recovery of Microvascular Status Evaluated by Optical Coherence Tomography Angiography in Patients after Successful Macular Hole Surgery.
[So] Source:Ophthalmic Res;59(1):53-57, 2018.
[Is] ISSN:1423-0259
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The aim of this study was to evaluate the optical coherence tomography angiography (OCTA) features of patients who underwent successful macular hole (MH) surgery. METHODS: Nineteen patients who underwent surgery in a single eye due to MH and 13 healthy subjects as a control group were included in the study. Vascular densities, flow indexes, and the foveal avascular zone (FAZ) area in superficial and deep retinal capillary plexuses were evaluated by OCTA in the right eyes of the control group, and both the surgical and healthy fellow eyes of the patients. RESULTS: The mean vascular densities of the superficial and deep capillary plexuses were significantly lower in the surgical eyes than in the control group (44.1 vs. 49.6%, p = 0.002, and 47.3 vs. 59.1%, p = 0.009, respectively). The mean superficial and deep capillary flow indexes were significantly lower in the surgical eyes than in the control group (0.85 vs. 1.35, p = 0.003, and 0.57 vs. 1.45, p = 0.001, respectively), while the mean superficial and deep FAZ area were significantly greater in the surgical eyes in comparison to the control group (0.55 vs. 0.32, p < 0.001, and 0.64 vs. 0.37, p = 0.001, respectively). There was no difference between the flow indexes of both layers of the healthy fellow eyes and the control group. CONCLUSIONS: These preliminary results may be an explanation for unsatisfactory visual gain after surgery, despite the successful anatomical closure of the MH.
[Mh] Termos MeSH primário: Fóvea Central/irrigação sanguínea
Microvasos/diagnóstico por imagem
Perfurações Retinianas/patologia
Vasos Retinianos/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso
Estudos de Casos e Controles
Feminino
Angiofluoresceinografia/métodos
Fóvea Central/diagnóstico por imagem
Seres Humanos
Macula Lutea/irrigação sanguínea
Masculino
Meia-Idade
Perfurações Retinianas/cirurgia
Estudos Retrospectivos
Tomografia de Coerência Óptica/métodos
Acuidade Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1159/000484092


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[PMID]:29343222
[Au] Autor:Liu B; Li Y; Li T; Lin Y; Ma W; Lu L
[Ad] Endereço:State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, China.
[Ti] Título:Transscleral tunnel incision related arterial hemorrhage in 23-gauge Vitrectomy: case report.
[So] Source:BMC Ophthalmol;18(1):9, 2018 Jan 17.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Transscleral tunnel incisions are commonly made to avoid postoperative leakage in small gauge sutureless vitrectomy. We present an unreported intraoperative complication, tunnel incision related arterial hemorrhage from sclerotomy, in 23-gauge (23G) vitrectomy. CASE PRESENTATION: Two cases of intraocular arterial hemorrhage from superonasal sclerotomy were observed at the beginning of vitrectomy. The bleeding filled the vitreous cavity quickly and gushed out from the incision port after the involved supronasal cannula was removed. The active bleeding seemed not to stop spontaneously. We controlled the active bleeding by relocating the involved cannula, elevating the intraocular pressure and compressing the sclera wound. Post-operative intraocular hemorrhage from the sclerotomy was not found in any of the two cases. CONCLUSIONS: We suggest that the bleeding was from injured ciliary artery when the incision crossed 3 or 9 o'clock accidently. Surgeons might avoid this complication by locating the superior incisions away from the horizontal axis, and should be aware the proper management.
[Mh] Termos MeSH primário: Perda Sanguínea Cirúrgica
Artérias Ciliares/lesões
Perfurações Retinianas/cirurgia
Esclera/cirurgia
Esclerostomia/efeitos adversos
Lesões do Sistema Vascular/complicações
Vitrectomia/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Hemostasia Cirúrgica/métodos
Seres Humanos
Pressão Intraocular
Masculino
Microcirurgia/efeitos adversos
Meia-Idade
Perfurações Retinianas/diagnóstico
Técnicas de Sutura/instrumentação
Tomografia de Coerência Óptica
Lesões do Sistema Vascular/diagnóstico
Lesões do Sistema Vascular/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180119
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0677-6


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[PMID]:28744658
[Au] Autor:Yun C; Ahn J; Kim M; Kim JT; Hwang SY; Kim SW; Oh J
[Ad] Endereço:Department of Ophthalmology, Korea University College of Medicine, 126-1 Anam-dong 5-ga, Sungbuk-gu, Seoul, 136-705, South Korea.
[Ti] Título:Characteristics of retinal vessels in surgically closed macular hole: an optical coherence tomography angiography study.
[So] Source:Graefes Arch Clin Exp Ophthalmol;255(10):1923-1934, 2017 Oct.
[Is] ISSN:1435-702X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The purpose of our study was to investigate characteristics of retinal vessels in eyes with surgically closed macular holes (MH). METHODS: We included patients who underwent surgery for idiopathic MH and a follow-up examination using optical coherence tomography angiography (OCTA). The area of the foveal avascular zone (FAZ) and retinal vascular densities of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were calculated on the postoperative OCTA images and compared with those of age-matched normal controls. RESULTS: Twenty-eight patients with MH and 28 controls were included. Mean postoperative FAZ areas of SCP and DCP (0.317 ± 0.129 mm and 0.500 ± 0.174 mm ) were smaller than those of normal controls (0.406 ± 0.131 mm and 0.687 ± 0.147 mm ) (P = 0.013 and P < 0.001, respectively). Retinal vascular densities of SCP and DCP in the MH group (32.23 ± 1.45% and 31.85 ± 1.28%) were lower than those of the control group (33.26 ± 1.71% and 33.18 ± 1.89%) (P = 0.019 and P = 0.003, respectively). The retinal vascular densities of SCP and DCP were associated with postoperative mean ganglion cell-inner plexiform layer (GC-IPL) thickness (P = 0.033 and P = 0.035, respectively). The vascular densities were horizontally asymmetric and related to asymmetric distribution of GC-IPL thickness in the MH group. CONCLUSIONS: Surgically closed MH eyes had remodeled retinal vascular patterns, which were related to morphologic changes in the inner retinal layer. The healing process after MH surgery may be involved in asymmetric change in anatomy and hemodynamics of the inner retina.
[Mh] Termos MeSH primário: Angiofluoresceinografia/métodos
Fóvea Central/irrigação sanguínea
Macula Lutea/patologia
Perfurações Retinianas/diagnóstico
Vasos Retinianos/diagnóstico por imagem
Acuidade Visual
Vitrectomia/métodos
[Mh] Termos MeSH secundário: Idoso
Capilares/patologia
Feminino
Fundo de Olho
Seres Humanos
Masculino
Período Pós-Operatório
Perfurações Retinianas/cirurgia
Estudos Retrospectivos
Tomografia de Coerência Óptica/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180110
[Lr] Data última revisão:
180110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1007/s00417-017-3742-6


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[PMID]:29208844
[Au] Autor:Bawankar P; Das D; Agarwal B; Bhattacharjee K; Tayab S; Deka P; Singh A; Borah E; Dhar S
[Ad] Endereço:Department of ophthalmology, Sri Sankaradeva Nethralaya, Guwahati, India.
[Ti] Título:A rare case of traumatic subretinal migration of crystalline lens, corroborated histologically.
[So] Source:Indian J Ophthalmol;65(12):1495-1497, 2017 Dec.
[Is] ISSN:1998-3689
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Blunt trauma is the most common cause of posterior dislocation of the crystalline lens. We describe a rare case of subretinal migration of crystalline lens through the giant retinal tear following blunt ocular trauma. This incidental finding of subretinal dislocation of lens following blunt ocular trauma was confirmed on histopathological examination of the enucleated eye. This complication has not been described by histopathological examination in literature so far.
[Mh] Termos MeSH primário: Traumatismos Oculares/complicações
Subluxação do Cristalino/etiologia
Cristalino/patologia
Ferimentos não Penetrantes/complicações
[Mh] Termos MeSH secundário: Adulto
Traumatismos Oculares/diagnóstico
Traumatismos Oculares/cirurgia
Seres Humanos
Subluxação do Cristalino/diagnóstico
Subluxação do Cristalino/cirurgia
Cristalino/lesões
Masculino
Procedimentos Cirúrgicos Oftalmológicos/métodos
Doenças Raras
Perfurações Retinianas/diagnóstico
Perfurações Retinianas/etiologia
Perfurações Retinianas/cirurgia
Ferimentos não Penetrantes/diagnóstico
Ferimentos não Penetrantes/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180103
[Lr] Data última revisão:
180103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE
[do] DOI:10.4103/ijo.IJO_613_17


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[PMID]:29202717
[Au] Autor:Giocanti-Aurégan A; Chbat EA; Morel CGH; Morin BR; Conrath JG; Devin FC
[Ad] Endereço:Ophthalmology department, Avicenne hospital, 125 rue de Stalingrad, 93000, Bobigny, France. audreygiocanti@yahoo.fr.
[Ti] Título:Ten years follow-up after surgery for a foveal detachment due to optic disc pit: a case report of outer retinal layer healing.
[So] Source:BMC Ophthalmol;17(1):231, 2017 Dec 04.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To report a case of complete progressive visual recovery and healing of outer retinal layers after vitrectomy for foveal detachment associated with optic disc pit. CASE PRESENTATION: Optical coherence tomography (OCT) follow-up was performed on a 15-year-old boy with deep optic disc pit and foveal detachment, before and for 10 years after vitrectomy with gas. The foveal detachment was successfully reattached with complete reapplication of the retina. OCT scans showed a progressive long-term retinal healing with reappearance of the ellipsoid line and visual acuity improved from 20/100 before surgery to 20/25, 10 years after surgery. CONCLUSIONS: Photoreceptor regeneration after foveal detachment surgery has been already described only in zebrafish but never humans. However, we highlight with this case that in humans, a healing process of the outer retinal layers can occur with reappearance of the ellipsoid zone on OCT. This healing process may take several years and allow a complete functional restoration.
[Mh] Termos MeSH primário: Anormalidades do Olho/complicações
Fóvea Central
Disco Óptico/anormalidades
Retina/fisiologia
Descolamento Retiniano/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Fóvea Central/cirurgia
Seres Humanos
Masculino
Regeneração
Perfurações Retinianas/cirurgia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-017-0626-9


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[PMID]:29255544
[Au] Autor:Maneh N; Tchapbou Moyou DC; Nonon Saa KB; Amedome MK; Dzidzinyo K; Diatewa BM; Ayena KD; Banla M; Balo KP
[Ad] Endereço:Université de Lomé, FSS, Service d'Ophtalmologie Chu-Campus de Lomé, Togo.
[Ti] Título:[Risk factors for retinal detachment in Togo].
[Ti] Título:Facteurs de risque du décollement de rétine au Togo..
[So] Source:Pan Afr Med J;28:74, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:fre
[Ab] Resumo:Introduction: Retinal detachment poses management problems in developing countries due to the shortage of technical equipment. Prevention passes through knowledge and elimination of risk factors. This study aimed to identify the risk factors for retinal detachment in people living in Togo. Methods: We conducted a retrospective and descriptive study in the Department of Ophthalmology at the Chu-Campus and in an ophthalmology office in Lomé from 2 January 2011 to 31 December 2015. The medical records of patients with retinal detachment were included in the study. The diagnosis of retinal detachment was confirmed based on funduscopic exam or ocular ultrasound. Results: in total, 116 eyes of 100 patients had retinal detachment of whom 40 in the RE, 44 in the LE and 16 bilaterally. The average age of patients was 46.65 ± 16.46 years [07 years; 87 years], with a male predominance and with a sex-ratio = 0.32 (W/M). Diabetic patients accounted for 17% and patients with sickle cell disease accounted for 16%. Myopic patients accounted for 5%, pseudophakic patients accounted for 17.2% and aphakic patients accounted for 3.4%. Four patients had retinal tear (14.28% of rhegmatogenous detachment) including 2 superotemporal tears, 1 inferior nasal tear and 1 inferior temporala tear. 35 eyes (52.2%) had total retinal detachment while 24 eyes (35.8%) had partial retinal detachment. Twenty eyes had vitreoretinal proliferations, 5 eyes had itreous hemorrhage and 6 eyes had hyalite. Diabetes and sickle cell disease were the risk factors for tractional RD (p=0.006 and p=0.0003) while cataract surgery was the risk factor for rhegmatogenous RD (p=0.0097). Conclusion: Diabetes, sickle cell anemia and eye surgery were the major risk factors for RD. A better management of these pathologies and ophthalmologist's mastery of cataract surgery may prevent retinal detachment.
[Mh] Termos MeSH primário: Anemia Falciforme/complicações
Extração de Catarata/efeitos adversos
Diabetes Mellitus/epidemiologia
Descolamento Retiniano/etiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Anemia Falciforme/epidemiologia
Criança
Feminino
Seres Humanos
Masculino
Meia-Idade
Descolamento Retiniano/diagnóstico
Perfurações Retinianas/epidemiologia
Estudos Retrospectivos
Fatores de Risco
Togo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.28.74.13418


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[PMID]:29191240
[Au] Autor:Crim N; Esposito E; Monti R; Correa LJ; Serra HM; Urrets-Zavalia JA
[Ad] Endereço:Department of Ophthalmology, University Clinic Reina Fabiola, Catholic University of Cordoba, Oncativo 1248, 5000, Cordoba, Argentina.
[Ti] Título:Myopia as a risk factor for subsequent retinal tears in the course of a symptomatic posterior vitreous detachment.
[So] Source:BMC Ophthalmol;17(1):226, 2017 Dec 01.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Retinal tears complicating the course of a posterior vitreous detachment (PVD) may be unique or multiple, and when multiple they may occur simultaneously or subsequently at different moments in the evolution of a PVD. The purpose of our study was to analyze the prevalence of subsequent retinal tears (SRT) in patients with a PVD, and to identify possible risk factors for SRT. METHODS: One hundred and seventy six eyes in 165 consecutive patients that presented one or more retinal tears in the evolution of a symptomatic PVD, with a minimum follow-up of 12 months, were retrospectively evaluated. The primary outcome measure was to characterize the clinical features associated with SRT formation against those eyes with non-subsequent retinal tear (NSRT-retinal tear/s diagnosed at initial examination) formation. For that purpose, this cohort of patients was divided into two different groups: group 1 included eyes presenting one or multiple retinal tears only at initial examination (NSRT), and group 2 eyes that progressed to a further retinal tear/s (SRT) during follow-up. RESULTS: Group 1 comprised 154 eyes from 145 patients, 48.7% males and 51.3% females with a mean age of 56.9 ± 14.0 years (range = 15-89); 17.2% of patients had a previous retinal tear or retinal detachment in the fellow eye; mean number of retinal tears per eye 1.42 ± 0.8 (range = 1-5); 20.8% presented bilateral retinal tears; 59.1% were myopic eyes (p < 0.05). Group 2 comprised 22 eyes from 20 patients; mean age was 53.3 ± 13.6 years (range = 30-69); 63.6% were male (p = 0.13), and 7 patients (31.8%) had a history of SRT or retinal detachment in the fellow eye (p = 0.13). The mean number of retinal tears per eye was 1.36 ± 0.5 (range = 1-2); bilateral retinal tears were noted in 18.2% of eyes; 86.4% were myopic eyes (p = 0.01); 81.8% occurred within a 120 days-period following diagnosis of the first retinal tear. CONCLUSIONS: Multiple retinal tears may be diagnosed in the evolution of a PVD. SRT are most frequently observed in myopic patients, and are usually symptomatic. Follow-up must extend for at least 4 months after the initial symptoms.
[Mh] Termos MeSH primário: Miopia/complicações
Perfurações Retinianas/epidemiologia
Descolamento do Vítreo/complicações
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Prevalência
Perfurações Retinianas/etiologia
Estudos Retrospectivos
Fatores de Risco
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-017-0629-6


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[PMID]:29179705
[Au] Autor:Yuan J; Zhang LL; Lu YJ; Han MY; Yu AH; Cai XJ
[Ad] Endereço:Department of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, People's Republic of China.
[Ti] Título:Vitrectomy with internal limiting membrane peeling versus inverted internal limiting membrane flap technique for macular hole-induced retinal detachment: a systematic review of literature and meta-analysis.
[So] Source:BMC Ophthalmol;17(1):219, 2017 Nov 28.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To evaluate the effects on vitrectomy with internal limiting membrane (ILM) peeling versus vitrectomy with inverted internal limiting membrane flap technique for macular hole-induced retinal detachment (MHRD). METHODS: Pubmed, Cochrane Library, and Embase were systematically searched for studies that compared ILM peeling with inverted ILM flap technique for macular hole-induced retinal detachment. The primary outcomes are the rate of retinal reattachment and the rate of macular hole closure 6 months later after initial surgery, the secondary outcome is the postoperative best-corrected visual acuity (BCVA) 6 months later after initial surgery. RESULTS: Four studies that included 98 eyes were selected. All the included studies were retrospective comparative studies. The preoperative best-corrected visual acuity was equal between ILM peeling and inverted ILM flap technique groups. It was indicated that the rate of retinal reattachment (odds ratio (OR) = 0.14, 95% confidence interval (CI):0.03 to 0.69; P = 0.02) and macular hole closure (OR = 0.06, 95% CI:0.02 to 0.19; P < 0.00001) after initial surgery was higher in the group of vitrectomy with inverted ILM flap technique than that in the group of vitrectomy with ILM peeling. However, there was no statistically significant difference in postoperative best-corrected visual acuity (mean difference (MD) 0.18 logarithm of the minimum angle of resolution; 95% CI -0.06 to 0.43 ; P = 0.14) between the two surgery groups. CONCLUSION: Compared with ILM peeling, vitrectomy with inverted ILM flap technique resulted significantly higher of the rate of retinal reattachment and macular hole closure, but seemed does not improve postoperative best-corrected visual acuity.
[Mh] Termos MeSH primário: Membrana Epirretiniana/cirurgia
Descolamento Retiniano/cirurgia
Perfurações Retinianas/cirurgia
Retalhos Cirúrgicos
Vitrectomia/métodos
[Mh] Termos MeSH secundário: Seres Humanos
Descolamento Retiniano/etiologia
Perfurações Retinianas/complicações
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-017-0619-8


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[PMID]:29179702
[Au] Autor:Cho JH; Yi HC; Bae SH; Kim H
[Ad] Endereço:Department of Ophthalmology, Kangnam Sacred Heart Hospital, Hallym University School of Medicine, 1, Singil-ro, Yeongdeungpo-gu, Seoul, 150-950, South Korea.
[Ti] Título:Foveal microvasculature features of surgically closed macular hole using optical coherence tomography angiography.
[So] Source:BMC Ophthalmol;17(1):217, 2017 Nov 28.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To describe the features of foveal microvasculature using optical coherence tomography angiography (OCTA) and to determine the related clinical factors in eyes with surgically closed macular hole (MH). METHODS: A retrospective case series of 18 patients with unilateral MH was reviewed. The patients maintained complete hole closure after vitrectomy with inner limiting membrane (ILM) peeling for at least 12 months. The healthy fellow eyes were studied as controls. The foveal microvasculature of both eyes was examined by OCTA. The area of the foveal avascular zone (FAZ) and the vascular density (VD) ratio in the superficial and deep capillary plexuses (SCP and DCP) were determined after surgery. Several clinical factors including age, stage and dimensions of MH, papillofoveal distance, the extent of nasal displacement of the fovea after surgery, postoperative central foveal thickness, and outer-retina integrity were evaluated to determine any relationships with the OCTA parameters. RESULTS: The mean FAZ area in both the SCP and DCP (0.29 ± 0.11 mm and 0.39 ± 0.14 mm ) was significantly smaller than those of the controls (0.45 ± 0.14 mm and 0.62 ± 0.22 mm ) (p = 0.001 and <0.001, respectively). The mean VD ratio in the SCP (0.270 ± 0.349) was similar to that of the controls (0.321 ± 0.189) (p = 0.231); however, that in the DCP (0.321 ± 0.189) was significantly lower than that of the controls (0.331 ± 0.119) (p = 0.025). Only the extent of nasal displacement of the fovea was correlated with the DCP FAZ-area difference values between the study group and the controls (correlation coefficient = 0.577; p = 0.012). CONCLUSIONS: After successful MH surgery, the FAZ area in both the SCP and DCP was smaller and the VD ratio of the DCP was lower, suggesting a possible DCP vulnerability to tractional stress. As the FAZ area of the DCP in closed-MH eyes became smaller than that in the controls, the fovea was less displaced toward the optic disc, possibly reflecting a lack of retinal redundancy caused by horizontal stretching accompanied by foveal displacement.
[Mh] Termos MeSH primário: Fóvea Central/irrigação sanguínea
Perfurações Retinianas/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Angiofluoresceinografia
Fóvea Central/diagnóstico por imagem
Seres Humanos
Masculino
Microvasos/diagnóstico por imagem
Meia-Idade
Perfurações Retinianas/cirurgia
Estudos Retrospectivos
Tomografia de Coerência Óptica
Vitrectomia/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-017-0607-z


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[PMID]:29049715
[Au] Autor:Obana A; Sasano H; Okazaki S; Otsuki Y; Seto T; Gohto Y
[Ad] Endereço:Department of Ophthalmology, Seirei Hamamatsu General Hospital, Naka-ku, Hamamatsu City, Shizuoka, Japan.
[Ti] Título:Evidence of Carotenoid in Surgically Removed Lamellar Hole-Associated Epiretinal Proliferation.
[So] Source:Invest Ophthalmol Vis Sci;58(12):5157-5163, 2017 Oct 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To determine the constituents and origin of the yellow pigment in surgically removed lamellar hole-associated epiretinal proliferation (LHEP) in patients with lamellar macular hole (LMH). Methods: This prospective case series comprised nine eyes with LMH in patients aged 41 to 83 years. The presence of LHEP was confirmed by preoperative optical coherence tomography; the distribution of macular pigment was observed by two-wavelength fundus autofluorescence technique before and after surgery. The subjects underwent a 25-gauge vitrectomy, and the surgically removed epiretinal membranous tissue was fixed with formalin. The specimens were examined using resonance Raman microscopy, and paraffin sections were stained with antiglial fibrillary acidic protein. Results: Seven cases presented with LHEP, and the presence of yellow pigment was confirmed using an operating microscope. Carotenoid-specific Raman signals with three major Raman peaks could be identified in the specimens with LHEP. These specimens were positive for glial fibrillary acidic protein staining. Using the fundus autofluorescence technique, a central defect in the distribution of the macular pigment was noted in the exact area of the lamellar hole. This type of defect was no longer visible after surgical repair of the lamellar hole. Conclusions: The constituents of the yellow pigment in the removed LHEP were carotenoids that typically originate from the macular xanthophyll pigments at the fovea. Since LHEP is reported to be composed of Müller cells, we hypothesize that xanthophyll carotenoids at the fovea are contained in the Müller cells.
[Mh] Termos MeSH primário: Membrana Epirretiniana/metabolismo
Pigmento Macular/metabolismo
Perfurações Retinianas/metabolismo
Xantofilas/metabolismo
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Biomarcadores/metabolismo
Membrana Epirretiniana/diagnóstico
Membrana Epirretiniana/cirurgia
Feminino
Fundo de Olho
Proteína Glial Fibrilar Ácida/metabolismo
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Perfurações Retinianas/diagnóstico
Perfurações Retinianas/cirurgia
Análise Espectral Raman
Tomografia de Coerência Óptica
Acuidade Visual
Vitrectomia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Glial Fibrillary Acidic Protein); 0 (Macular Pigment); 0 (Xanthophylls)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22347



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