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  1 / 2795 MEDLINE  
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[PMID]:28451988
[Au] Autor:Badhani A; Padhi TR; Panda GK; Mukherjee S; Das T; Jalali S
[Ad] Endereço:Department of Vitreoretinal services, LV Prasad Eye Institute, Bhubaneswar, Odisha, India.
[Ti] Título:Correlation of macular structure and function in a boy with primary foveomacular retinitis and sequence of changes over 5 years.
[So] Source:Doc Ophthalmol;135(1):43-52, 2017 08.
[Is] ISSN:1573-2622
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To describe the clinical characteristics, macular structure and function, and to document sequential changes over 5 years in a 10-year-old boy with bilateral primary foveomacular retinitis. METHODS: A 10-year-old boy presented with sudden onset scotoma in both eyes, experienced after getting up from bed on a non-eclipse day. He persistently denied direct sun-gazing. He neither had any significant systemic illness, nor was using any medications. In addition to a detailed examination at presentation that included fundus fluorescein angiogram (FFA), electroretinogram (ERG), pattern ERG and electrooculogram (EOG), he was examined periodically for 5 years with Humphrey visual field (HVF), spectral domain optical coherence tomogram (SDOCT), Amsler grid charting and multifocal ERG. The macular structure and functions were analyzed over the years and correlated with the symptoms. RESULTS: All findings were bilaterally symmetrical at each visit. At presentation, his corrected visual acuity was 20/25 with subfoveal yellow dot similar to solar retinopathy, central scotoma with reduced foveal threshold in HVF 24-2, micropsia in Amsler grid, missing of two plates on Ishihara color vision chart, transfoveal full thickness hyper-reflective band on SD OCT, unremarkable FFA and normal foveal peak in mfERG. The flash ERG and EOG were unremarkable. A month later, his VA improved to 20/20, he had relative scotoma in Amsler grid, no scotoma in HVF (10-2), restoration of the inner segment of the photoreceptors with sharp defect involving ellipsoid and photoreceptor interdigitation zone in SDOCT and blunting of foveal peaks in mfERG. Three months later, his corrected VA was 20/20 with relative scotoma in Amsler grid, normal color vision, no scotoma in HVF 10-2 and unchanged SDOCT findings. In subsequent examinations at 6, 9, 14, 29, 39 and 60 months, he was symptomless with VA 20/20, unremarkable fundus, normal Amsler grid and HVF (normal foveal threshold), unchanged SDOCT findings and the reduced foveal peaks on mfERG in both eyes got normalized only at 60 months. CONCLUSION: Presented here is a case of bilaterally symmetrical idiopathic foveomacular retinitis that had a clinical appearance similar to solar retinopathy. The fundus changes persisted for 4 weeks, the symptoms and changes in Amsler grid lasted for 3 months, and the foveal threshold in visual fields normalized within 3 months. Maximum change in the SDOCT defect occurred within a month, and the extrafoveal defect in the ellipsoid and photoreceptor interdigitation line persisted despite resolution of symptoms and resolution of the visual field defect and normal distance vision. Probably, the foveal lesion detected on SDOCT was too small to cause a reduction in the distance visual acuity or show up in the visual field and mfERG later.
[Mh] Termos MeSH primário: Fóvea Central/fisiopatologia
Retinite/fisiopatologia
Escotoma/fisiopatologia
[Mh] Termos MeSH secundário: Criança
Eletroculografia
Eletrorretinografia
Angiofluoresceinografia
Seguimentos
Seres Humanos
Masculino
Retinite/diagnóstico
Escotoma/diagnóstico
Estatística como Assunto
Tomografia de Coerência Óptica
Acuidade Visual/fisiologia
Testes de Campo Visual
Campos Visuais/fisiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1007/s10633-017-9590-1


  2 / 2795 MEDLINE  
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[PMID]:28985573
[Au] Autor:Bauer D; Keller J; Alt M; Schubert A; Aufderhorst UW; Palapys V; Kasper M; Heilingloh CS; Dittmer U; Laffer B; Eis-Hübinger AM; Verjans GM; Heiligenhaus A; Roggendorf M; Krawczyk A
[Ad] Endereço:Ophtha-Lab, Department of Ophthalmology at St. Franziskus Hospital, Muenster, Germany.
[Ti] Título:Antibody-based immunotherapy of aciclovir resistant ocular herpes simplex virus infections.
[So] Source:Virology;512:194-200, 2017 Dec.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The increasing incidence of aciclovir- (ACV) resistant strains in patients with ocular herpes simplex virus (HSV) infections is a major health problem in industrialized countries. In the present study, the humanized monoclonal antibody (mAb) hu2c targeting the HSV-1/2 glycoprotein B was examined for its efficacy towards ACV-resistant infections of the eye in the mouse model of acute retinal necrosis (ARN). BALB/c mice were infected by microinjection of an ACV-resistant clinical isolate into the anterior eye chamber to induce ARN and systemically treated with mAb hu2c at 24h prior (pre-exposure prophylaxis) or at 24, 40, and 56h after infection (post-exposure immunotherapy). Mock treated controls and ACV-treated mice showed pronounced retinal damage. Mice treated with mAb hu2c were almost completely protected from developing ARN. In conclusion, mAb hu2c may become a reliable therapeutic option for drug/ACV-resistant ocular HSV infections in humans in order to prevent blindness.
[Mh] Termos MeSH primário: Aciclovir/farmacologia
Anticorpos Monoclonais/uso terapêutico
Anticorpos Antivirais/imunologia
Herpesviridae/efeitos dos fármacos
Imunoterapia
Retinite/virologia
[Mh] Termos MeSH secundário: Animais
Antivirais/farmacologia
Farmacorresistência Viral
Feminino
Herpesviridae/imunologia
Seres Humanos
Camundongos
Camundongos Endogâmicos BALB C
Retinite/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Antibodies, Viral); 0 (Antiviral Agents); X4HES1O11F (Acyclovir)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE


  3 / 2795 MEDLINE  
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[PMID]:28984726
[Au] Autor:Amer R; Tugal-Tutkun I
[Ad] Endereço:aDepartment of Ophthalmology, Hadassah Medical Center, Jerusalem bDepartment of Ophthalmology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
[Ti] Título:Ophthalmic manifestations of bartonella infection.
[So] Source:Curr Opin Ophthalmol;28(6):607-612, 2017 Nov.
[Is] ISSN:1531-7021
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: The eye is commonly affected in disseminated cat scratch disease (CSD) caused by Bartonella species. This article reviews recently published data on epidemiology of CSD, clinical features of ocular involvement, diagnosis and treatment. RECENT FINDINGS: The annual incidence of CSD has been estimated as 4.7 per 100 000 in the United States. It occurs predominantly in the southern states, with a peak in January, and disproportionately affects children. Retinal infiltrates, neuroretinitis and branch retinal artery occlusions have been reported as common manifestations of ocular bartonellosis in recent series. The use of different antigens for serodiagnosis and new real-time PCR assays for molecular diagnosis have been described. Despite lack of a standard treatment, good visual outcomes were generally reported in patients with ocular bartonellosis. SUMMARY: Bartonella infections continue to be a burden worldwide and epidemiologic features may guide preventive measures in high-risk regions and populations. An increased awareness of diverse posterior segment manifestations will lead to an early diagnosis of ocular bartonellosis. Laboratory diagnostic methods continue to evolve and may be applied to the investigation of ocular fluids for a definitive diagnosis of ocular bartonellosis. Well designed clinical trials are required to establish the optimum treatment of especially sight-threatening manifestations.
[Mh] Termos MeSH primário: Bartonella henselae
Doença da Arranhadura de Gato/diagnóstico
Infecções Oculares Bacterianas/diagnóstico
Retinite/diagnóstico
[Mh] Termos MeSH secundário: Animais
Doença da Arranhadura de Gato/epidemiologia
Doença da Arranhadura de Gato/terapia
Infecções Oculares Bacterianas/epidemiologia
Infecções Oculares Bacterianas/terapia
Seres Humanos
Incidência
Reação em Cadeia da Polimerase em Tempo Real
Retinite/epidemiologia
Retinite/terapia
Testes Sorológicos
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE
[do] DOI:10.1097/ICU.0000000000000419


  4 / 2795 MEDLINE  
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[PMID]:28837731
[Au] Autor:Li J; Ren J; Yip YWY; Zhang X; Chu KO; Ng TK; Chan SO; Pang CP; Chu WK
[Ad] Endereço:Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
[Ti] Título:Quantitative Characterization of Autoimmune Uveoretinitis in an Experimental Mouse Model.
[So] Source:Invest Ophthalmol Vis Sci;58(10):4193-4200, 2017 Aug 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To accurately evaluate the autoimmune inflammation, we aim to develop three quantitative measurements to monitor the inflammatory changes in the retina: retinal-choroidal thickness, major retinal vessel diameter, and electroretinography amplitudes. Methods: During a 21-day experimental period, eyes were examined by confocal scanning laser ophthalmoscopy, optical coherence tomography, fundus fluorescein angiography, and electroretinography in living mice, which were then subsequently killed for histologic assessments. Results: On day 21 postimmunization, inflammation was observed both in vivo and in vitro. Fold change of retinal-choroidal thickness and major retinal vessel diameter in experimental autoimmune uveoretinitis mice were significantly greater than controls (P < 0.001). Both scotopic and photopic electroretinography amplitudes were significantly attenuated when compared with control mice (P < 0.01). Our results showed that these three quantifiable indicators provided an objective and accurate evaluation of autoimmune inflammation, which are in good correlations with the reported clinical and histopathologic scoring systems (P < 0.05). Conclusions: These three indicators will be useful to detect the small but significant differences in the severity of experimental autoimmune uveoretinitis for future longitudinally therapeutic studies.
[Mh] Termos MeSH primário: Doenças Autoimunes/diagnóstico
Modelos Animais de Doenças
Retina/fisiopatologia
Vasos Retinianos/patologia
Retinite/diagnóstico
Uveíte/diagnóstico
[Mh] Termos MeSH secundário: Animais
Autoantígenos
Doenças Autoimunes/imunologia
Doenças Autoimunes/fisiopatologia
Permeabilidade Capilar
Dilatação Patológica
Eletrorretinografia
Proteínas do Olho
Feminino
Angiofluoresceinografia
Camundongos
Camundongos Endogâmicos C57BL
Oligopeptídeos
Oftalmoscopia
Retinite/imunologia
Retinite/fisiopatologia
Proteínas de Ligação ao Retinol
Uveíte/imunologia
Uveíte/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Autoantigens); 0 (Eye Proteins); 0 (Oligopeptides); 0 (Retinol-Binding Proteins); 0 (interstitial retinol-binding protein)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170825
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22436


  5 / 2795 MEDLINE  
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[PMID]:28613359
[Au] Autor:Türkcü FM; Sahin A; Yüksel H; Sahin M; Karaalp Ü
[Ti] Título:OCTA Imaging of Choroidal Neovascular Membrane Secondary to Toxoplasma Retinochoroiditis.
[So] Source:Ophthalmic Surg Lasers Imaging Retina;48(6):509-511, 2017 Jun 01.
[Is] ISSN:2325-8179
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Two patients (a 37-year-old man and a 28-year-old woman) who had choroidal neovascular membrane (CNVM) secondary to inactive toxoplasma retinochoroiditis scarring were evaluated. Multimodal imaging including fluorescein angiography, optical coherence tomography (OCT), and OCT angiography (OCTA) was used. CNVM secondary to inactive toxoplasma retinochoroiditis scarring was detected. Representative images of CNVM were demonstrated in the outer retinal layer and choriocapillary layer on OCTA. OCTA, a relatively new technique, is useful in the diagnosis of the CNVMs secondary to retinochoroiditis. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:509-511.].
[Mh] Termos MeSH primário: Neovascularização de Coroide/diagnóstico
Corioidite/complicações
Infecções Oculares Parasitárias/complicações
Angiofluoresceinografia/métodos
Retinite/complicações
Tomografia de Coerência Óptica/métodos
Toxoplasmose Ocular/complicações
[Mh] Termos MeSH secundário: Adulto
Animais
Antígenos de Protozoários/imunologia
Corioide/irrigação sanguínea
Neovascularização de Coroide/etiologia
Corioidite/diagnóstico
Corioidite/parasitologia
Infecções Oculares Parasitárias/diagnóstico
Feminino
Seres Humanos
Masculino
Retinite/diagnóstico
Retinite/parasitologia
Toxoplasma/imunologia
Toxoplasmose Ocular/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Protozoan)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.3928/23258160-20170601-11


  6 / 2795 MEDLINE  
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[PMID]:28440258
[Au] Autor:Guliani BP; Kumar S; Chawla N; Mehta A
[Ad] Endereço:Department of Ophthalmology, VMMC and Safdarjung Hospital, New Delhi, India.
[Ti] Título:Neuroretinitis as presenting and the only presentation of Lyme disease: Diagnosis and management.
[So] Source:Indian J Ophthalmol;65(3):250-252, 2017 Mar.
[Is] ISSN:1998-3689
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:We present a case of neuroretinitis as presenting and the only presentation of Lyme disease in a 25-year-old female who visited hilly areas in the Himalayas of North India. She presented with right eye sudden and painless blurring of vision. Her vision at presentation was 20/60. She had fundus examination; fundus fluorescein angiography (FFA) and optical coherence tomography (OCT) imaging showed classical features of neuroretinitis. No other organ was involved. Oral steroids were prescribed and relevant investigations sent for noninfective and infective causes. Worsened visual acuity (VA) to hand movement and positive IgM titers for Borrelia burgdorferi led to the diagnosis of Lyme disease-associated neuroretinitis. Treatment with oral doxycycline plus oral steroids for 4 weeks revealed VA of 20/20 and resolution of fundus and OCT changes. Neuroretinitis as presenting and the only presentation of Lyme disease will be discussed with serial fundus, FFA, and OCT pictures.
[Mh] Termos MeSH primário: Doxiciclina/administração & dosagem
Angiofluoresceinografia/métodos
Doença de Lyme/complicações
Disco Óptico/patologia
Prednisona/administração & dosagem
Retinite/diagnóstico
Tomografia de Coerência Óptica/métodos
[Mh] Termos MeSH secundário: Administração Oral
Adulto
Antibacterianos/administração & dosagem
Quimioterapia Combinada
Feminino
Seguimentos
Fundo de Olho
Glucocorticoides/administração & dosagem
Seres Humanos
Doença de Lyme/diagnóstico
Retinite/tratamento farmacológico
Retinite/etiologia
Acuidade Visual
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Glucocorticoids); N12000U13O (Doxycycline); VB0R961HZT (Prednisone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE
[do] DOI:10.4103/ijo.IJO_151_17


  7 / 2795 MEDLINE  
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[PMID]:28418948
[Au] Autor:Zatreanu L; Sibony PA; Kupersmith MJ
[Ad] Endereço:Department of Ophthalmology (LZ, PAS), State University of New York at Stony Brook, Stony Brook, New York; and Department of Neurology and Ophthalmology (MJK), Icahn School of Medicine at Mount Sinai, Mt. Sinai Roosevelt and the New York Eye and Ear Infirmary, New York, New York.
[Ti] Título:Optical Coherence Tomography in Neuroretinitis: Epipapillary Infiltrates and Retinal Folds.
[So] Source:J Neuroophthalmol;37(2):176-178, 2017 Jun.
[Is] ISSN:1536-5166
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neuroretinitis is a form of papillitis associated with the delayed onset of an exudative macular star among other inflammatory ocular findings. We describe 4 patients with neuroretinitis who displayed several distinctive and novel findings on spectral-domain optical coherence tomography (OCT) that include "epipapillary infiltrates" and an atypical pattern of inner retinal folds. The recognition of these findings on OCT may help in the early diagnosis of neuroretinitis.
[Mh] Termos MeSH primário: Diagnóstico Precoce
Retina/patologia
Retinite/diagnóstico
Tomografia de Coerência Óptica/métodos
Acuidade Visual
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1097/WNO.0000000000000501


  8 / 2795 MEDLINE  
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[PMID]:28322199
[Au] Autor:Imai A; Toriyama Y; Iesato Y; Hirabayashi K; Sakurai T; Kamiyoshi A; Ichikawa-Shindo Y; Kawate H; Tanaka M; Liu T; Xian X; Zhai L; Dai K; Tanimura K; Liu T; Cui N; Yamauchi A; Murata T; Shindo T
[Ad] Endereço:Department of Cardiovascular Research, Shinshu University Graduate School of Medicine, Nagano, Japan; Department of Ophthalmology, Shinshu University School of Medicine, Nagano, Japan.
[Ti] Título:Adrenomedullin Suppresses Vascular Endothelial Growth Factor-Induced Vascular Hyperpermeability and Inflammation in Retinopathy.
[So] Source:Am J Pathol;187(5):999-1015, 2017 May.
[Is] ISSN:1525-2191
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Diabetic macular edema (DME) is caused by blood-retinal barrier breakdown associated with retinal vascular hyperpermeability and inflammation, and it is the major cause of visual dysfunction in diabetic retinopathy. Adrenomedullin (ADM) is an endogenous peptide first identified as a strong vasodilator. ADM is expressed in the eyes and is up-regulated in various eye diseases, although the pathophysiological significance is largely unknown. We investigated the effect of ADM on DME. In Kimba mice, which overexpress human vascular endothelial growth factor in their retinas, the capillary dropout, vascular leakage, and vascular fragility characteristic of diabetic retinopathy were observed. Intravitreal or systemic administration of ADM to Kimba mice ameliorated both the capillary dropout and vascular leakage. Evaluation of the transendothelial electrical resistance and fluorescein isothiocyanate-dextran permeability of an endothelial cell monolayer using TR-iBRB retinal capillary endothelial cells revealed that vascular endothelial growth factor enhanced vascular permeability but that co-administration of ADM suppressed the effect, in part by enhancing tight junction formation between endothelial cells. In addition, a comprehensive PCR array analysis showed that ADM administration suppressed various molecules related to inflammation and NF-κB signaling within retinas. From these results, we suggest that by exerting inhibitory effects on retinal inflammation, vascular permeability, and blood-retinal barrier breakdown, ADM could serve as a novel therapeutic agent for the treatment of DME.
[Mh] Termos MeSH primário: Adrenomedulina/farmacologia
Permeabilidade Capilar/efeitos dos fármacos
Retinopatia Diabética/fisiopatologia
Fator A de Crescimento do Endotélio Vascular/farmacologia
Vasodilatadores/farmacologia
[Mh] Termos MeSH secundário: Adrenomedulina/administração & dosagem
Animais
Células Cultivadas
Diabetes Mellitus Experimental/fisiopatologia
Impedância Elétrica
Células Endoteliais/fisiologia
Injeções Intravítreas
Masculino
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
NF-kappa B/metabolismo
Retinite/fisiopatologia
Vasodilatadores/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (NF-kappa B); 0 (Vascular Endothelial Growth Factor A); 0 (Vasodilator Agents); 148498-78-6 (Adrenomedullin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE


  9 / 2795 MEDLINE  
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[PMID]:28284786
[Au] Autor:Iu LPL; Lee R; Fan MCY; Lam WC; Chang RT; Wong IYH
[Ad] Endereço:Department of Ophthalmology, The University of Hong Kong, Grantham Hospital, Hong Kong.
[Ti] Título:Serial Spectral-Domain Optical Coherence Tomography Findings in Acute Retinal Pigment Epitheliitis and the Correlation to Visual Acuity.
[So] Source:Ophthalmology;124(6):903-909, 2017 Jun.
[Is] ISSN:1549-4713
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To evaluate the features of acute retinal pigment epitheliitis (ARPE) at onset and in the course of recovery by serial spectral-domain optical coherence tomography (SD OCT) and the correlation to visual acuity (VA). DESIGN: Retrospective cohort study. PARTICIPANTS: Consecutive patients with ARPE. METHODS: A review of medical records was performed. MAIN OUTCOME MEASURES: Integrity of SD OCT retinal bands at onset and in the course of disease, time required to achieve each retinal band restoration, corresponding VA change, and final VA. RESULTS: Four patients were included. Initial SD OCT showed a dome-shaped hyper-reflective lesion at the photoreceptor outer segment layer disrupting the ellipsoid zone (EZ) and interdigitation zone (IZ) (100%). In the early phase, there was also upward displacement of the external limiting membrane (ELM) and mild transient thickening of the retinal pigment epithelium (RPE)/Bruch's complex (Bc). Acute retinal pigment epitheliitis resolved in a sequence of (1) a decrease in height of SD OCT hyper-reflective lesion and the upwardly displaced ELM returning to its normal position with irregularity; (2) complete disappearance of the hyper-reflective lesion; (3) restoration of ELM; (4) restoration of EZ; and (5) restoration of IZ. The average time to restore ELM, EZ, and IZ was 4.3±5.2, 7.3±7.2, and 12.5±12.4 weeks, respectively, and the corresponding logarithm of the minimum angles of resolution (logMAR) VAs were 0.24±0.23, 0.09±0.07, and 0.05±0.06, respectively. Visual acuity improved when IZ was restored. CONCLUSIONS: Early SD OCT revealed an inflammatory lesion in the photoreceptor outer segment layer displacing ELM. The RPE was involved only mildly and transiently. Recovery occurred in a sequence of ELM, EZ, and IZ restoration, and VA improved when the IZ was restored. These features suggested that the IZ (i.e., the contact between photoreceptors and RPE) is the primary site of inflammation in ARPE.
[Mh] Termos MeSH primário: Epitélio Pigmentado da Retina/patologia
Retinite/diagnóstico
Tomografia de Coerência Óptica
Acuidade Visual/fisiologia
[Mh] Termos MeSH secundário: Doença Aguda
Administração Oral
Adolescente
Adulto
Estudos de Coortes
Feminino
Glucocorticoides/uso terapêutico
Seres Humanos
Masculino
Epitélio Pigmentado da Retina/efeitos dos fármacos
Retinite/tratamento farmacológico
Retinite/fisiopatologia
Estudos Retrospectivos
Estatística como Assunto
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE


  10 / 2795 MEDLINE  
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[PMID]:28237172
[Au] Autor:Cao Y; Zhao X; Yi J; Tang R; Lei S
[Ad] Endereço:From the Department of Ophthalmology, The Third Xiangya Hospital, Central South University, Hunan, China.
[Ti] Título:Hantavirus retinitis and concurrent hemorrhagic fever with renal syndrome.
[So] Source:Can J Ophthalmol;52(1):e41-e44, 2017 Feb.
[Is] ISSN:1715-3360
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Infecções Oculares Virais/complicações
Infecções por Hantavirus/complicações
Hantavirus/genética
Febre Hemorrágica com Síndrome Renal/complicações
Retinite/complicações
[Mh] Termos MeSH secundário: DNA Viral/análise
Infecções Oculares Virais/diagnóstico
Infecções Oculares Virais/virologia
Angiofluoresceinografia
Fundo de Olho
Infecções por Hantavirus/diagnóstico
Infecções por Hantavirus/virologia
Febre Hemorrágica com Síndrome Renal/diagnóstico
Seres Humanos
Masculino
Meia-Idade
Retina/patologia
Retinite/diagnóstico
Retinite/virologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170227
[St] Status:MEDLINE



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