Base de dados : MEDLINE
Pesquisa : C11.790.500 [Categoria DeCS]
Referências encontradas : 1123 [refinar]
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  1 / 1123 MEDLINE  
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[PMID]:27772649
[Au] Autor:Raven ML; Burris CK; Potter HD
[Ad] Endereço:Department of Ophthalmology and Visual Sciences, University of Wisconsin - Madison.
[Ti] Título:Scleritis with Devastating Consequences.
[So] Source:Ophthalmology;123(11):2337, 2016 11.
[Is] ISSN:1549-4713
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Cegueira/etiologia
Esclerite/complicações
[Mh] Termos MeSH secundário: Adulto
Doenças da Córnea/etiologia
Enucleação Ocular
Glaucoma/induzido quimicamente
Glucocorticoides/efeitos adversos
Seres Humanos
Masculino
Recidiva
Esclerite/diagnóstico
Esclerite/tratamento farmacológico
Doenças da Úvea/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  2 / 1123 MEDLINE  
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[PMID]:29433463
[Au] Autor:Todokoro D; Hoshino J; Yo A; Makimura K; Hirato J; Akiyama H
[Ad] Endereço:Department of Ophthalmology, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma, 371-8511, Japan. dtodokor@gunma-u.ac.jp.
[Ti] Título:Scedosporium apiospermum infectious scleritis following posterior subtenon triamcinolone acetonide injection: a case report and literature review.
[So] Source:BMC Ophthalmol;18(1):40, 2018 Feb 13.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Ubiquitous fungi of the Scedosporium apiospermum species complex (SASC) cause various opportunistic infections. Posterior subtenon triamcinolone acetonide (STTA) injection is a standard therapy for intraocular inflammation and macular edema. We report a case of Scedosporium apiospermum infectious scleritis after a posterior STTA injection. CASE PRESENTATION: A 75-year-old man received a posterior STTA injection to treat macular edema in his left eye. After 3 months, he complained of ocular pain and hyperemia in his left eye. Examination showed a subtenon abscess in the site corresponding with the STTA injection. After incising the abscess, the smear revealed numerous conidia-like structures. Although we suspected fungal infection and started topical voriconazole (VRCZ) and levofloxacin, the inflammation of the eye worsened. Fungal culture revealed filamentous fungus growth. Subsequently, we added systemic VRCZ and performed surgical debridement of the infected sclera and Tenon's capsule. Pathology of the sclera showed fungal hyphae. The antifungal susceptibility test revealed low minimum inhibitory concentrations for micafungin, VRCZ and miconazole (0.06, 0.25 and 0.5 µg/mL, respectively). After 2 months, the ciliary injection subsided and VRCZ therapy was stopped. However, subtenon abscess recurred 1 month after discontinuation of topical VRCZ. Surgical debridement and topical VRCZ were resumed, with the eye finally improving after 5 months of management. The fungal species was identified as Scedosporium apiospermum sensu stricto morphologically and by DNA sequencing. CONCLUSIONS: This case was successfully treated by topical and systemic VRCZ and repeated surgical debridement. Infectious scleritis caused by SASC rarely develops after posterior STTA. SASC can produce conidia in the enclosed subtenon space. Late-onset infectious scleritis after a posterior STTA injection suggests the presence of a fungal infection, including SASC, thereby requiring extensive and prolonged medical and surgical treatment.
[Mh] Termos MeSH primário: Infecções Oculares Fúngicas/microbiologia
Imunossupressores/administração & dosagem
Micoses/microbiologia
Complicações Pós-Operatórias
Scedosporium/isolamento & purificação
Esclerite/microbiologia
Triancinolona Acetonida/administração & dosagem
[Mh] Termos MeSH secundário: Idoso
Antifúngicos/uso terapêutico
Terapia Combinada
Desbridamento
Infecções Oculares Fúngicas/diagnóstico
Infecções Oculares Fúngicas/terapia
Seres Humanos
Injeções Intraoculares
Edema Macular/tratamento farmacológico
Imagem por Ressonância Magnética
Masculino
Testes de Sensibilidade Microbiana
Micoses/diagnóstico
Micoses/terapia
Esclerite/diagnóstico
Esclerite/terapia
Cápsula de Tenon/efeitos dos fármacos
Voriconazol/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Immunosuppressive Agents); F446C597KA (Triamcinolone Acetonide); JFU09I87TR (Voriconazole)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180218
[Lr] Data última revisão:
180218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180214
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0707-4


  3 / 1123 MEDLINE  
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[PMID]:29382031
[Au] Autor:Ryu SJ; Kang MH; Seong M; Cho H; Shin YU
[Ad] Endereço:Department of Ophthalmology, Hanyang University College of Medicine, Seoul, Korea.
[Ti] Título:Anterior scleritis following intravitreal injections in a patient with rheumatoid arthritis: A case report.
[So] Source:Medicine (Baltimore);96(47):e8925, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Surgically induced scleritis is a rare complication following ophthalmologic surgery such as cataract surgery, pterygium excision, strabismus surgery, and retinal detachment repair. Rheumatoid arthritis (RA) is the connective tissue disease most commonly associated with scleritis. PATIENT CONCERNS: A 70-year-old woman visited our clinic with complaint of visual disturbance, ocular pain, and conjunctival injection in her right eye of 1 month's duration. She had a stable state of rheumatoid factor positive RA and had a history of multiple intravitreal injections placed in the symptomatic right eye due to age-related macular degeneration. DIAGNOSES: Anterior scleritis induced by multiple intravitreal injections. INTERVENTIONS: Topical and systemic steroids were administered. OUTCOMES: Her symptoms and signs were relieved and no significant recurrence has been occurred with the maintenance of low dose oral steroid. LESSONS: Surgically induced scleritis can also be induced by not only major surgical trauma but also by relatively minor trauma such as intravitreal injection (especially in patients who have connective tissue disease such as RA).
[Mh] Termos MeSH primário: Artrite Reumatoide/tratamento farmacológico
Injeções Intravítreas/efeitos adversos
Esclerite/etiologia
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008925


  4 / 1123 MEDLINE  
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[PMID]:28957561
[Au] Autor:Ungprasert P; Crowson CS; Cartin-Ceba R; Garrity JA; Smith WM; Specks U; Matteson EL; Makol A
[Ad] Endereço:Division of Rheumatology, Department of Internal Medicine.
[Ti] Título:Clinical characteristics of inflammatory ocular disease in anti-neutrophil cytoplasmic antibody associated vasculitis: a retrospective cohort study.
[So] Source:Rheumatology (Oxford);56(10):1763-1770, 2017 Oct 01.
[Is] ISSN:1462-0332
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objective: To characterize the clinical correlates and outcome of inflammatory ocular disease (IOD) among patients with ANCA-associated vasculitides (AAV). Methods: Medical records of potential cases of AAV seen at Mayo Clinic from 2003 to 2013, inclusive, were reviewed to identify confirmed cases meeting the diagnosis of AAV using the Chapel Hill Consensus Conference 2012 descriptors. Records of confirmed cases of AAV were then further reviewed for IOD, and clinical characteristics, treatment and outcomes abstracted. Results: A total of 1171 confirmed cases of AAV were identified of which 183 patients (mean age 49.0 years; 51% female; 95% Caucasian) had IOD. The most common manifestation of IOD was injection of the eye (57%) followed by eye pain (46%) and visual acuity loss (18%). Scleritis was the most common type of IOD (22%) followed by episcleritis (21%), orbital inflammation (18%), lacrimal duct stenosis (10%) and uveitis (9%). Oral glucocorticoids were used to treat IOD in the majority of patients (96%). CYC and rituximab were the most frequently used immunosuppressive agents (54 and 36%, respectively). Of those with orbital inflammation, 52% underwent therapeutic surgical intervention. Clinical remission of IOD was achieved in 91% of patients but relapses were seen in 23%. Significant visual acuity loss was observed in only six patients. Conclusion: IOD is a common manifestation of AAV and seen in about 16% of patients with AAV. Scleritis, episcleritis and orbital inflammation are the most common subtypes. Most patients respond well to glucocorticoids and immunosuppression, but relapse of IOD is common.
[Mh] Termos MeSH primário: Vasculite Associada a Anticorpo Anticitoplasma de Neutrófilos/complicações
Oftalmopatias/imunologia
Doenças Orbitárias/imunologia
Esclerite/imunologia
[Mh] Termos MeSH secundário: Adulto
Oftalmopatias/tratamento farmacológico
Oftalmopatias/patologia
Feminino
Glucocorticoides/uso terapêutico
Seres Humanos
Imunossupressores/uso terapêutico
Masculino
Meia-Idade
Doenças Orbitárias/tratamento farmacológico
Doenças Orbitárias/patologia
Recidiva
Estudos Retrospectivos
Esclerite/tratamento farmacológico
Esclerite/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids); 0 (Immunosuppressive Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE
[do] DOI:10.1093/rheumatology/kex261


  5 / 1123 MEDLINE  
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[PMID]:28858963
[Au] Autor:Derzko-Dzulynsky L
[Ad] Endereço:University of Toronto, Department of Ophthalmology and Vision Sciences, Canada.
[Ti] Título:IgG4-related disease in the eye and ocular adnexa.
[So] Source:Curr Opin Ophthalmol;28(6):617-622, 2017 Nov.
[Is] ISSN:1531-7021
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: IgG4-related disease is a multi-organ fibro-inflammatory disease with characteristic histopathology showing lymphoplasmacytic infiltration, increased IgG4+ plasma cells and elevated IgG4/IgG ratios (>40%). The lacrimal gland is the most common ocular site of involvement. Scleritis and intraocular involvement in IgG4-related ophthalmic disease (IgG4-ROD) have recently been reported. The purpose of this review is to describe orbital and intraocular IgG4-ROD with a focus on publications since 2016. RECENT FINDINGS: Case reports of scleritis and uveitis in IgG4-ROD have been described since 2012. Systemic prednisone is recommended as the first-line treatment, but immunosuppressive therapy may be required for steroid-sparing or in steroid-resistant cases. High rates of systemic IgG4-RD involvement exist in patients with bilateral IgG4-ROD or if the lacrimal gland is involved. Rituximab is the most specific immune targeted therapy available with high rates of remission. SUMMARY: IgG4-ROD is an emerging cause of scleritis and uveitis and should be considered in any patient with multisystem inflammatory disease. New targeted immune therapies may improve outcomes and lead to clinical remission.
[Mh] Termos MeSH primário: Oftalmopatias/imunologia
Imunoglobulina G
Paraproteinemias/imunologia
[Mh] Termos MeSH secundário: Dacriocistite/diagnóstico
Dacriocistite/tratamento farmacológico
Dacriocistite/imunologia
Oftalmopatias/diagnóstico
Oftalmopatias/tratamento farmacológico
Glucocorticoides/uso terapêutico
Seres Humanos
Imunoglobulina G/imunologia
Imunossupressores/uso terapêutico
Pseudotumor Orbitário/diagnóstico
Pseudotumor Orbitário/tratamento farmacológico
Pseudotumor Orbitário/imunologia
Paraproteinemias/diagnóstico
Paraproteinemias/tratamento farmacológico
Esclerite/diagnóstico
Esclerite/tratamento farmacológico
Esclerite/imunologia
Uveíte/diagnóstico
Uveíte/tratamento farmacológico
Uveíte/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Glucocorticoids); 0 (Immunoglobulin G); 0 (Immunosuppressive Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1097/ICU.0000000000000427


  6 / 1123 MEDLINE  
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[PMID]:28643721
[Au] Autor:Derhy D; Sauer A; Sabou M; Letsch J; Candolfi E; Letscher-Bru V; Bourcier T
[Ad] Endereço:Department of Ophthalmology, Strasbourg University Hospital, FMTS, University of Strasbourg, 67000 Strasbourg, France.
[Ti] Título:Surgical treatment of sclerokeratitis and endophthalmitis.
[So] Source:Indian J Ophthalmol;65(6):523-526, 2017 Jun.
[Is] ISSN:1998-3689
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:A 55-year-old nurse was referred with a 5-month history of right eye corneal abscess. The initial injury occurred when doing lawn work. The infection worsened despite multiple antibiotic, antiviral, and steroid treatments. Visual acuity was limited to hand motion. On examination, there was keratitis, ocular hypertension, and a secondary cataract. Corneal scrapings grew a filamentous fungus, identified as Metarhizium anisopliae (MA). Despite intensive antifungal treatment with topical, intravitreous, and systemic voriconazole, purulent corneal melting and scleritis with endophthalmitis rapidly appeared. An emergency surgical procedure including sclerocorneal transplantation, cataract surgery, a pars plana vitrectomy using temporary keratoprosthesis, and scleral crosslinking was necessary. One year after the surgery, there was no recurrence of infection. Functional outcome remained very poor. This is the first case of sclerokeratitis and endophthalmitis caused by MA ever reported. The infection was successfully treated with an aggressive combination of medical and surgical treatments.
[Mh] Termos MeSH primário: Endoftalmite/cirurgia
Infecções Oculares Fúngicas/cirurgia
Ceratite/cirurgia
Metarhizium/isolamento & purificação
Procedimentos Cirúrgicos Oftalmológicos/métodos
Esclerite/cirurgia
Acuidade Visual
[Mh] Termos MeSH secundário: Córnea/anormalidades
Córnea/cirurgia
Doenças da Córnea/cirurgia
Endoftalmite/diagnóstico
Endoftalmite/microbiologia
Infecções Oculares Fúngicas/diagnóstico
Infecções Oculares Fúngicas/microbiologia
Feminino
Seres Humanos
Ceratite/diagnóstico
Ceratite/microbiologia
Meia-Idade
Esclerite/diagnóstico
Esclerite/microbiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170624
[St] Status:MEDLINE
[do] DOI:10.4103/ijo.IJO_461_16


  7 / 1123 MEDLINE  
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[PMID]:28394239
[Au] Autor:Gonzales JA; Haemel A; Gross AJ; Acharya NR
[Ad] Endereço:1 F.I. Proctor Foundation, University of California , San Francisco, San Francisco, California.
[Ti] Título:Management of Uveitis and Scleritis in Necrobiotic Xanthogranuloma.
[So] Source:J Ocul Pharmacol Ther;33(4):325-333, 2017 May.
[Is] ISSN:1557-7732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Necrobiotic xanthogranuloma (NXG) is a chronic, progressive non-Langerhans histiocytic granulomatous disease. While case reports describing periorbital involvement of NXG are frequent, only a few case reports describing ocular involvement, such as scleritis and uveitis, exist. Herein, we present a case presenting initially as bilateral anterior and posterior scleritis, as well as a chronic bilateral granulomatous panuveitis, and discuss the immunosuppressant options that should be considered for this disease with protean manifestations.
[Mh] Termos MeSH primário: Xantogranuloma Necrobiótico/complicações
Xantogranuloma Necrobiótico/terapia
Esclerite/complicações
Esclerite/terapia
Uveíte/complicações
Uveíte/terapia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Xantogranuloma Necrobiótico/diagnóstico
Esclerite/diagnóstico
Uveíte/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE
[do] DOI:10.1089/jop.2016.0135


  8 / 1123 MEDLINE  
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[PMID]:28372717
[Au] Autor:Tarff A; Behrens A
[Ad] Endereço:The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 North Broadway, Suite 4001, Baltimore, MD 21231, USA.
[Ti] Título:Ocular Emergencies: Red Eye.
[So] Source:Med Clin North Am;101(3):615-639, 2017 May.
[Is] ISSN:1557-9859
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:"Red eye" is used as a general term to describe irritated or bloodshot eyes. It is a recognizable sign of an acute/chronic, localized/systemic underlying inflammatory condition. Conjunctival injection is most commonly caused by dryness, allergy, visual fatigue, contact lens overwear, and local infections. In some instances, red eye can represent a true ocular emergency that should be treated by an ophthalmologist. A comprehensive assessment of red eye conditions is required to preserve the patients visual function. Severe ocular pain, significant photophobia, decreased vision, and history of ocular trauma are warning signs demanding immediate ophthalmological consultation.
[Mh] Termos MeSH primário: Emergências
Oftalmopatias/fisiopatologia
Oftalmopatias/terapia
[Mh] Termos MeSH secundário: Blefarite/fisiopatologia
Blefarite/terapia
Conjuntivite/diagnóstico
Conjuntivite/fisiopatologia
Lesões da Córnea/terapia
Síndromes do Olho Seco/tratamento farmacológico
Síndromes do Olho Seco/fisiopatologia
Endoftalmite/fisiopatologia
Endoftalmite/terapia
Oftalmopatias/diagnóstico
Corpos Estranhos no Olho/terapia
Glaucoma de Ângulo Fechado/fisiopatologia
Glaucoma de Ângulo Fechado/terapia
Hemorragia/fisiopatologia
Hemorragia/terapia
Seres Humanos
Inflamação
Ceratite/diagnóstico
Ceratite/fisiopatologia
Esclerite/fisiopatologia
Esclerite/terapia
Uveíte/fisiopatologia
Uveíte/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE


  9 / 1123 MEDLINE  
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[PMID]:28355124
[Au] Autor:Stem MS; Todorich B; Faia LJ
[Ad] Endereço:1 Associated Retinal Consultants P.C. , Royal Oak, Michigan.
[Ti] Título:Ocular Pharmacology for Scleritis: Review of Treatment and a Practical Perspective.
[So] Source:J Ocul Pharmacol Ther;33(4):240-246, 2017 May.
[Is] ISSN:1557-7732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Scleritis is defined as an infectious or noninfectious inflammation of the sclera that can be broadly categorized according to anatomic location (ie, anterior or posterior) and whether the process is necrotizing or non-necrotizing. Treatment for scleritis is dictated by the etiology of the inflammation, with infectious forms requiring treatment of the inciting agent and noninfectious forms requiring treatment of the underlying inflammation with immunosuppression. Pharmacotherapy for noninfectious scleritis can be classified according to delivery route (eg, local or systemic) and mechanism of action (eg, biologic or nonbiologic). This review will briefly summarize the classification scheme for scleritis before reviewing in depth both systemic and local pharmacotherapies that can be used to effectively treat an eye afflicted by either infectious or noninfectious scleritis. Traditional anti-inflammatory agents such as nonsteroidal anti-inflammatory drugs, steroids, and immunomodulatory therapy will be discussed, as well as newer biologic therapies such as antitumor necrosis factor alpha and anti-CD20 agents.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/uso terapêutico
Imunomodulação
Esclerite/tratamento farmacológico
Esteroides/uso terapêutico
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Steroids)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170330
[St] Status:MEDLINE
[do] DOI:10.1089/jop.2016.0127


  10 / 1123 MEDLINE  
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[PMID]:28337043
[Au] Autor:Young N
[Ad] Endereço:General Medicine Department, Auckland City Hospital, Grafton.
[Ti] Título:Poststreptococcal episcleritis.
[So] Source:N Z Med J;130(1452):66-67, 2017 Mar 24.
[Is] ISSN:1175-8716
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:This report describes the case of a patient presenting with an unusual poststreptococcal syndrome that featured episcleritis as a prominent manifestation. To my knowledge, this is the first time that poststreptococcal episcleritis has been described in the literature.
[Mh] Termos MeSH primário: Faringite/complicações
Esclerite/etiologia
Infecções Estreptocócicas/complicações
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Meia-Idade
Streptococcus pyogenes
Síndrome
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE



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