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[PMID]:28396945
[Au] Autor:Albavera-Giles T; Serna-Ojeda JC; Jimenez-Corona A; Pedroza-Seres M
[Ad] Endereço:Department of Uveitis and Ocular Immunology, Instituto de Oftalmologia "Conde de Valenciana", Mexico City, Mexico.
[Ti] Título:Outcomes of cataract surgery with/without vitrectomy in patients with pars planitis and immunosuppressive therapy.
[So] Source:Graefes Arch Clin Exp Ophthalmol;255(6):1213-1219, 2017 Jun.
[Is] ISSN:1435-702X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The purpose of this study was to evaluate the characteristics and outcomes of cataract surgery with/without vitrectomy in patients with pars planitis who received immunosuppressive therapy. METHODS: This was a retrospective case series, single-center study. Twenty-two patients with pars planitis who received immunosuppressive therapy were included, with a median age at presentation of 9.5 years, having had cataract surgery. The following data was collected: age at presentation and at cataract surgery, time of follow-up, best-corrected visual acuity (BCVA) before the surgery and at 1 week, 1 and 6 months after the procedure, immunosuppressive therapy, complications and causes for failed visual improvement. The variables associated with an improvement in visual acuity were evaluated. RESULTS: All patients had phacoemulsification with intraocular lens implantation. The most common immunosuppressive therapy used for the patients was methotrexate in nine patients (40.9%). The BCVA improved from a median of 20/400 to 20/100 after 6 months of follow-up (p = 0.0005); 14 patients (63.6%) improved two lines of vision or more. No significant risk factors were found for the association with improvement in visual acuity after the surgery. No improvement in visual acuity was attributed to posterior segment manifestations or amblyopia; the most common complication was posterior capsule opacification in 11 eyes (50%). The median follow-up after the surgery was 32 months. CONCLUSION: Phacoemulsification was the procedure for all the patients. Visual acuity improved in patients with pars planitis treated with immunosuppressive drugs who underwent cataract surgery, except for the patients with posterior segment complications or amblyopia.
[Mh] Termos MeSH primário: Catarata/complicações
Imunossupressão/métodos
Imunossupressores/uso terapêutico
Pars Planite/complicações
Facoemulsificação/métodos
Acuidade Visual
Vitrectomia/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Pré-Escolar
Feminino
Seguimentos
Seres Humanos
Implante de Lente Intraocular/métodos
Masculino
Pars Planite/diagnóstico
Pars Planite/terapia
Estudos Retrospectivos
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Immunosuppressive Agents)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.1007/s00417-017-3658-1


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[PMID]:28002192
[Au] Autor:Vinod K; Panarelli JF; Gentile RC; Sidoti PA
[Ad] Endereço:Department of Ophthalmology, Icahn School of Medicine at Mount Sinai and New York Eye and Ear Infirmary of Mount Sinai, New York, NY.
[Ti] Título:Long-term Outcomes and Complications of Pars Plana Baerveldt Implantation in Children.
[So] Source:J Glaucoma;26(3):266-271, 2017 Mar.
[Is] ISSN:1536-481X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF THE STUDY: The purpose of the study was to report long-term outcomes and complications of Baerveldt glaucoma implant (BGI) surgery with pars plana tube insertion in children. MATERIALS AND METHODS: The medical records of consecutive aphakic and pseudophakic children (<16 y of age) who underwent BGI surgery with pars plana tube insertion between 1990 and 2013 were retrospectively reviewed. Main outcome measures were intraocular pressure and number of glaucoma medications. Postoperative complications were recorded. Failure was defined as an intraocular pressure <5 or ≥21 mm Hg (with or without glaucoma medications), loss of light perception, or need for additional glaucoma surgery. RESULTS: Thirty-seven children were identified with a mean age of 6.0±4.7 years (range, 4 mo to 14.5 y). Mean follow-up after pars plana BGI surgery was 6.5±3.4 years (range, 9 mo to 12.8 y) for patients who met success criteria. Mean intraocular pressure and mean number of glaucoma medications at most recent follow-up for patients with successful intraocular pressure control were 13.8±4.1 and 2.3±1.9 mm Hg, respectively. The Kaplan-Meier survival analysis revealed 1-, 3-, 5-, and 7-year success rates of 94.5%, 74.6%, 65.0%, and 45.8%, respectively. Complications included tube exposure in 1 patient (2.7%), tube obstruction in 8 patients (21.6%), and retinal detachment in 9 patients (24.3%). Seventeen patients (45.9%) failed due to inadequate intraocular pressure control, of whom 9 (24.3%) required additional glaucoma surgery. CONCLUSIONS: Although pars plana BGI surgery is a reasonable option for managing refractory glaucoma in aphakic and pseudophakic children, surgeons must be aware of the potential need for additional glaucoma surgery and/or posterior segment complications with extended follow-up.
[Mh] Termos MeSH primário: Implantes para Drenagem de Glaucoma
Glaucoma/cirurgia
Implante de Prótese/métodos
[Mh] Termos MeSH secundário: Adolescente
Anti-Hipertensivos/uso terapêutico
Afacia/cirurgia
Criança
Pré-Escolar
Corpo Ciliar/cirurgia
Feminino
Glaucoma/fisiopatologia
Seres Humanos
Pressão Intraocular/fisiologia
Estimativa de Kaplan-Meier
Masculino
Pars Planite
Complicações Pós-Operatórias/epidemiologia
Complicações Pós-Operatórias/etiologia
Pseudofacia/cirurgia
Descolamento Retiniano/cirurgia
Estudos Retrospectivos
Resultado do Tratamento
Acuidade Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antihypertensive Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161222
[St] Status:MEDLINE
[do] DOI:10.1097/IJG.0000000000000611


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[PMID]:26576712
[Au] Autor:Sohn EH; Chaon BC; Jabs DA; Folk JC
[Ad] Endereço:Department of Ophthalmology and Visual Sciences, Stephen A. Wynn Institute for Vision Research, University of Iowa Hospitals and Clinics, Iowa City, Iowa. Electronic address: Elliott.Sohn@gmail.com.
[Ti] Título:Peripheral Cryoablation for Treatment of Active Pars Planitis: Long-Term Outcomes of a Retrospective Study.
[So] Source:Am J Ophthalmol;162:35-42.e2, 2016 Feb.
[Is] ISSN:1879-1891
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To compare the long-term outcomes of peripheral retinal cryoablation to conventional treatment for active pars planitis. DESIGN: Retrospective, interventional, comparative case series. METHODS: Review at a single institution was conducted to compare the effect of cryotherapy to eyes with pars planitis to those receiving conventional therapy (topical, regionally injected, or oral corticosteroid therapy). Best-corrected visual acuity (VA), complications, resolution of cystoid macular edema (CME), and anterior chamber and vitreous inflammation were assessed. RESULTS: One hundred thirty-six eyes were treated conventionally, 50 eyes were treated with cryotherapy. Median follow-up was 60.8 months (range 8.1-223.1 months) in the cryotherapy group and 45.0 months (range 3.1-339.0 months) in the controls. There were no significant differences in baseline VA, anterior chamber and vitreous inflammation, presence of CME, and prior use of regional corticosteroid injections. VA improved over time in the cryotherapy group (slope of -0.0018 logMAR units per month; P = .023) but declined in the controls (slope of +0.0011 logMAR units per month; P = .023). Kaplan-Meier survival estimates demonstrated faster times to resolution of anterior chamber cell, vitreous cell, and CME in the cryotherapy-treated eyes. Hazard ratios of remission (adjusted for confounding factors) for vitreous cell and CME for those treated with cryotherapy compared to controls were 4.73 (95% confidence interval 1.63, 13.63; P = .004) and 6.85 (95% confidence interval 1.06, 44.78; P = .044), respectively. No ocular complications were identified in the cryotherapy group. CONCLUSIONS: These data suggest that peripheral retinal cryoablation therapy is an effective treatment for active pars planitis and may be better than conventional regional corticosteroid injections and oral corticosteroid therapy for induction of remission.
[Mh] Termos MeSH primário: Crioterapia/métodos
Pars Planite/terapia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Câmara Anterior/patologia
Criança
Crioterapia/efeitos adversos
Oftalmopatias/patologia
Feminino
Seguimentos
Seres Humanos
Edema Macular/fisiopatologia
Masculino
Meia-Idade
Pars Planite/fisiopatologia
Estudos Retrospectivos
Resultado do Tratamento
Acuidade Visual/fisiologia
Corpo Vítreo/patologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160126
[Lr] Data última revisão:
160126
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:151119
[St] Status:MEDLINE


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[PMID]:26449229
[Au] Autor:Lembo A; Pichi F; Santangelo E; Carrai P; Hadjistilianou T; Serafino M; Nucci P
[Ad] Endereço:San Giuseppe Hospital, University Eye Clinic, Via San Vittore 12, 20123, Milan, Italy. andrealembo1984@hotmail.com.
[Ti] Título:Two masquerade presentations of retinoblastoma.
[So] Source:Int Ophthalmol;36(2):275-9, 2016 Apr.
[Is] ISSN:1573-2630
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Masquerade syndromes are disorders occurring with intraocular inflammation misdiagnosed as uveitis. The underlying causes may be benign or malignant conditions, and one of the most important diagnoses to take into consideration in children is retinoblastoma. We present two cases with uncertain early misdiagnosis whose definite diagnosis eventually was retinoblastoma.
[Mh] Termos MeSH primário: Neoplasias da Retina/diagnóstico
Retinoblastoma/diagnóstico
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Diagnóstico Diferencial
Feminino
Seres Humanos
Masculino
Pars Planite/diagnóstico
Descolamento Retiniano/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1612
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151010
[St] Status:MEDLINE
[do] DOI:10.1007/s10792-015-0134-y


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[PMID]:26438050
[Au] Autor:Przezdziecka-Dolyk J; Wegrzyn A; Turno-Krecicka A; Misiuk-Hojlo M
[Ad] Endereço:Department and Clinic of Ophthalmology, Wroclaw Medical University, Borowska 213, 50-556, Wroclaw, Poland. arie_l@wp.pl.
[Ti] Título:Immunopathogenic Background of Pars Planitis.
[So] Source:Arch Immunol Ther Exp (Warsz);64(2):127-37, 2016 Apr.
[Is] ISSN:1661-4917
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Pars planitis is defined as an intermediate uveitis of unknown background of systemic disease with characteristic formations such as vitreous snowballs, snowbanks and changes in peripheral retina. The incidence of pars planitis varies 2.4-15.4 % of the uveitis patients. The pathogenesis of the disease is to be determined in future. Clinical and histopathological findings suggest an autoimmune etiology, most likely as a reaction to endogenous antigen of unknown source, with T cells predominant in both vitreous and pars plana infiltrations. T cells subsets play an important role as a memory-effector peripheral cell. Snowbanks are formed as an effect of post inflammatory glial proliferation of fibrous astrocytes. There is also a genetic predisposition for pars planitis by human leukocyte antigen and several other genes. A coexistence of multiple sclerosis and optic neuritis has been described in numerous studies. Epiretinal membrane, cataract, cystoid macular edema, retinal detachment, retinal vasculitis, neovascularization, vitreous peripheral traction, peripheral hole formation, vitreous hemorrhage, disc edema are common complications observed in pars planitis. There is a need to expand the knowledge of the pathogenic and immunologic background of the pars planitis to create an accurate pharmacological treatment.
[Mh] Termos MeSH primário: Autoimunidade
Olho/imunologia
Pars Planite/imunologia
Subpopulações de Linfócitos T/imunologia
Linfócitos T/imunologia
[Mh] Termos MeSH secundário: Animais
Olho/patologia
Predisposição Genética para Doença
Antígenos HLA/genética
Seres Humanos
Memória Imunológica
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (HLA Antigens)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151007
[St] Status:MEDLINE
[do] DOI:10.1007/s00005-015-0361-y


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[PMID]:26587811
[Au] Autor:Listernick R
[Ti] Título:A 12-Year-Old Boy with Pars Planitis.
[So] Source:Pediatr Ann;44(11):462-4, 2015 Nov.
[Is] ISSN:1938-2359
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Pars Planite/diagnóstico
Sarcoidose/diagnóstico
[Mh] Termos MeSH secundário: Criança
Diagnóstico Diferencial
Seres Humanos
Masculino
Pars Planite/etiologia
Peptidil Dipeptidase A/sangue
Sarcoidose/complicações
Uveíte/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; CLINICAL CONFERENCE; JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.4.15.1 (Peptidyl-Dipeptidase A)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151121
[Lr] Data última revisão:
151121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151121
[St] Status:MEDLINE
[do] DOI:10.3928/00904481-20151112-02


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[PMID]:25870216
[Au] Autor:Amin RM; Hamdy I; Osman IM
[Ad] Endereço:Department of Ophthalmology, Alexandria Faculty of Medicine, Alexandria, Egypt.
[Ti] Título:Chronic candida endophthalmitis as a cause of intermediate uveitis.
[So] Source:BMJ Case Rep;2015, 2015 Apr 13.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Intermediate uveitis is a subset of intraocular inflammation where vitritis is the most consistent sign, with or without snowball opacities or snow banks over the pars plana. Some patients will have an associated underlying systemic disease such as sarcoidosis, multiple sclerosis, ocular tuberculosis, inflammatory bowel disease, possibly Behçet's disease and intraocular lymphoma, whereas some will be classified as pars planitis in case of the lack of an identifiable systemic disease association. Our patient, a 47-year-old woman, developed intermediate uveitis after cataract surgery in her right eye, was misdiagnosed as pars planitis, and received steroid monotherapy for 8 months. Her inflammation only fully resolved after vitrectomy with removal of the intraocular lens (IOL) and capsular bag. Oral fluconazole and intravitreal amphotericin B injection had failed to resolve her inflammation when Candida albicans was identified as the cause of her persistent intermediate uveitis.
[Mh] Termos MeSH primário: Candida albicans/isolamento & purificação
Endoftalmite/diagnóstico
Endoftalmite/tratamento farmacológico
Infecções Oculares Fúngicas/diagnóstico
Uveíte Intermediária/diagnóstico
[Mh] Termos MeSH secundário: Administração Oral
Anfotericina B/administração & dosagem
Anfotericina B/uso terapêutico
Extração de Catarata/métodos
Erros de Diagnóstico
Endoftalmite/microbiologia
Endoftalmite/fisiopatologia
Infecções Oculares Fúngicas/tratamento farmacológico
Infecções Oculares Fúngicas/microbiologia
Feminino
Fluconazol/administração & dosagem
Fluconazol/uso terapêutico
Seres Humanos
Injeções Intravítreas
Meia-Idade
Pars Planite/diagnóstico
Complicações Pós-Operatórias/diagnóstico
Esteroides/administração & dosagem
Esteroides/uso terapêutico
Resultado do Tratamento
Uveíte Intermediária/fisiopatologia
Uveíte Intermediária/terapia
Vitrectomia/métodos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Steroids); 7XU7A7DROE (Amphotericin B); 8VZV102JFY (Fluconazole)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:170413
[Lr] Data última revisão:
170413
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150415
[St] Status:MEDLINE


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[PMID]:24985727
[Au] Autor:Serna-Ojeda JC; Pedroza-Seres M
[Ad] Endereço:Department of Uveitis and Ocular Immunology, Instituto de Oftalmologia "Conde de Valenciana", Mexico City, Mexico.
[Ti] Título:Treatment with immunosuppressive therapy in patients with pars planitis: experience of a reference centre in Mexico.
[So] Source:Br J Ophthalmol;98(11):1503-7, 2014 Nov.
[Is] ISSN:1468-2079
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIM: To evaluate the clinical course of the patients with pars planitis that received immunosuppressive drugs. METHODS: We retrospectively analysed the data of 10 years from 374 patients with pars planitis in a large reference centre in Mexico City and included 49 patients (92 eyes). RESULTS: Median age at presentation was 8 years. 35 patients (71.4%) were male and 43 patients (87.7%) had bilateral disease. Diverse immunosuppressive medications were used, mainly methotrexate (69.4%) and azathioprine (63.3%) with 18 patients requiring more than one drug. The main indications for starting immunosuppressive therapy were lack of response to initial treatment and advance disease at presentation. The results showed good response with steroid reduction (69.3% of patients), visual acuity improvement (51% of patients) and inflammatory disease reduction (59.1% of patients). In 25 patients (51%), steroids were started previous to immunosuppressors and in 24 (49%) at the same time without significant difference in clinical improvement (p=0.210) or visual outcome (p=0.498). Thirteen patients (26.5%) presented mild adverse effects. The median of the final visual acuity was 20/40. The median follow-up time was 44 months (range 13-115 months). CONCLUSIONS: Immunosuppressive therapy allows an adequate control of inflammatory disease in pars planitis, with clinical and visual improvement and steroid dose reduction.
[Mh] Termos MeSH primário: Imunossupressores/uso terapêutico
Pars Planite/tratamento farmacológico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Azatioprina/efeitos adversos
Azatioprina/uso terapêutico
Criança
Pré-Escolar
Ciclofosfamida/efeitos adversos
Ciclofosfamida/uso terapêutico
Ciclosporina/efeitos adversos
Ciclosporina/uso terapêutico
Feminino
Seres Humanos
Imunossupressores/efeitos adversos
Masculino
Metotrexato/efeitos adversos
Metotrexato/uso terapêutico
México
Meia-Idade
Pars Planite/diagnóstico
Encaminhamento e Consulta
Estudos Retrospectivos
Acuidade Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Immunosuppressive Agents); 83HN0GTJ6D (Cyclosporine); 8N3DW7272P (Cyclophosphamide); MRK240IY2L (Azathioprine); YL5FZ2Y5U1 (Methotrexate)
[Em] Mês de entrada:1503
[Cu] Atualização por classe:141021
[Lr] Data última revisão:
141021
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140703
[St] Status:MEDLINE
[do] DOI:10.1136/bjophthalmol-2014-304913


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[PMID]:24574435
[Au] Autor:Beykin G; Pe'er J; Hemo Y; Frenkel S; Chowers I
[Ad] Endereço:Department of Ophthalmology, Hadassah-Hebrew University Medical Center, , Jerusalem, Israel.
[Ti] Título:Authors' response: Pars planavitrectomy to repair retinal detachment following brachytherapy for uveal melanoma.
[So] Source:Br J Ophthalmol;98(4):571-2, 2014 Apr.
[Is] ISSN:1468-2079
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Braquiterapia/efeitos adversos
Melanoma/radioterapia
Pars Planite/cirurgia
Descolamento Retiniano/cirurgia
Neoplasias Uveais/radioterapia
Vitrectomia/métodos
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:COMMENT; LETTER
[Em] Mês de entrada:1405
[Cu] Atualização por classe:140321
[Lr] Data última revisão:
140321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140228
[St] Status:MEDLINE
[do] DOI:10.1136/bjophthalmol-2014-304970


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[PMID]:24390168
[Au] Autor:Chia SN; Smith HB; Kemp EG
[Ad] Endereço:Department of Ophthalmology, Tennent Institute of Ophthalmology, , Glasgow, UK.
[Ti] Título:Comment on: 'Pars plana vitrectomy to repair retinal detachment following brachytherapy for uveal melanoma'.
[So] Source:Br J Ophthalmol;98(4):571, 2014 Apr.
[Is] ISSN:1468-2079
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Braquiterapia/efeitos adversos
Melanoma/radioterapia
Pars Planite/cirurgia
Descolamento Retiniano/cirurgia
Neoplasias Uveais/radioterapia
Vitrectomia/métodos
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:COMMENT; LETTER
[Em] Mês de entrada:1405
[Cu] Atualização por classe:140321
[Lr] Data última revisão:
140321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140107
[St] Status:MEDLINE
[do] DOI:10.1136/bjophthalmol-2013-304749



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