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[PMID]:29194680
[Au] Autor:Jenkins S; Ives J; Avery S; Draper H
[Ti] Título:Who gets the gametes? An argument for a points system for fertility patients.
[So] Source:Bioethics;32(1):16-26, 2018 01.
[Is] ISSN:1467-8519
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This paper argues that the convention of allocating donated gametes on a 'first come, first served' basis should be replaced with an allocation system that takes into account more morally relevant criteria than waiting time. This conclusion was developed using an empirical bioethics methodology, which involved a study of the views of 18 staff members from seven U.K. fertility clinics, and 20 academics, policy-makers, representatives of patient groups, and other relevant professionals, on the allocation of donated sperm and eggs. Against these views, we consider some nuanced ways of including criteria in a points allocation system. We argue that such a system is more ethically robust than 'first come, first served', but we acknowledge that our results suggest that a points system will meet with resistance from those working in the field. We conclude that criteria such as a patient's age, potentially damaging substance use, and parental status should be used to allocate points and determine which patients receive treatment and in what order. These and other factors should be applied according to how they bear on considerations like child welfare, patient welfare, and the effectiveness of the proposed treatment.
[Mh] Termos MeSH primário: Temas Bioéticos
Doação Dirigida de Tecido/ética
Células Germinativas
Acesso aos Serviços de Saúde/ética
Infertilidade
Reprodução/ética
[Mh] Termos MeSH secundário: Adulto
Atitude do Pessoal de Saúde
Bioética
Dissidências e Disputas
Feminino
Fertilidade
Seres Humanos
Masculino
Pais
Discriminação Social
Participação dos Interessados
Reino Unido
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:E; IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1111/bioe.12411


  2 / 9556 MEDLINE  
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[PMID]:28455751
[Au] Autor:Hipp H; Crawford S; Kawwass JF; Boulet SL; Grainger DA; Kissin DM; Jamieson D
[Ad] Endereço:Division of Reproductive Endocrinology and Infertility, Emory University School of Medicine, Emory University, 550 Peachtree Street, Suite 1800, Atlanta, GA, 30308, USA. hhipp@emory.edu.
[Ti] Título:National trends and outcomes of autologous in vitro fertilization cycles among women ages 40 years and older.
[So] Source:J Assist Reprod Genet;34(7):885-894, 2017 Jul.
[Is] ISSN:1573-7330
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The purpose of the study was to describe trends in and investigate variables associated with clinical pregnancy and live birth in autologous in vitro fertilization (IVF) cycles among women ≥40 years. METHODS: We used autologous IVF cycle data from the National ART Surveillance System (NASS) for women ≥40 years at cycle start. We assessed trends in fresh and frozen cycles (n = 371,536) from 1996 to 2013. We reported perinatal outcomes and determined variables associated with clinical pregnancy and live birth in fresh cycles between 2007 and 2013. RESULTS: From 1996 to 2013, the total number of cycles in women ≥40 years increased from 8672 to 28,883 (p < 0.0001), with frozen cycles almost tripling in the last 8 years. Cycles in women ≥40 years accounted for 16.0% of all cycles in 1996 and 21.0% in 2013 (p < 0.0001). For fresh cycles from 2007 to 2013 (n = 157,890), the cancelation rate was 17.1%. Among cycles resulting in transfer (n = 112,414), the live birth rate was 16.1%. The following were associated with higher live birth rates: multiparity, fewer prior ART cycles, use of standard agonist or antagonist stimulation, lower gonadotropin dose, ovarian hyperstimulation syndrome, more oocytes retrieved, use of pre-implantation genetic screening/diagnosis, transferring more and/or blastocyst stage embryos, and cryopreserving more supernumerary embryos. Of the singleton infants born (n = 14,992), 86.9% were full term and 88.3% normal birth weight. CONCLUSIONS: The NASS allows for a comprehensive description of IVF cycles in women ≥40 years in the USA. Although live birth rate is less than 20%, identifying factors associated with IVF success can facilitate treatment option counseling.
[Mh] Termos MeSH primário: Fertilização In Vitro/tendências
Taxa de Gravidez
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Centers for Disease Control and Prevention (U.S.)
Feminino
Fertilização In Vitro/estatística & dados numéricos
Seres Humanos
Infertilidade/terapia
Gravidez
Resultado do Tratamento
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1007/s10815-017-0926-2


  3 / 9556 MEDLINE  
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[PMID]:29330225
[Au] Autor:Maione L; Dwyer AA; Francou B; Guiochon-Mantel A; Binart N; Bouligand J; Young J
[Ad] Endereço:University of Paris-SudParis-Sud Medical School, Le Kremlin-Bicêtre, France.
[Ti] Título:GENETICS IN ENDOCRINOLOGY: Genetic counseling for congenital hypogonadotropic hypogonadism and Kallmann syndrome: new challenges in the era of oligogenism and next-generation sequencing.
[So] Source:Eur J Endocrinol;178(3):R55-R80, 2018 Mar.
[Is] ISSN:1479-683X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Congenital hypogonadotropic hypogonadism (CHH) and Kallmann syndrome (KS) are rare, related diseases that prevent normal pubertal development and cause infertility in affected men and women. However, the infertility carries a good prognosis as increasing numbers of patients with CHH/KS are now able to have children through medically assisted procreation. These are genetic diseases that can be transmitted to patients' offspring. Importantly, patients and their families should be informed of this risk and given genetic counseling. CHH and KS are phenotypically and genetically heterogeneous diseases in which the risk of transmission largely depends on the gene(s) responsible(s). Inheritance may be classically Mendelian yet more complex; oligogenic modes of transmission have also been described. The prevalence of oligogenicity has risen dramatically since the advent of massively parallel next-generation sequencing (NGS) in which tens, hundreds or thousands of genes are sequenced at the same time. NGS is medically and economically more efficient and more rapid than traditional Sanger sequencing and is increasingly being used in medical practice. Thus, it seems plausible that oligogenic forms of CHH/KS will be increasingly identified making genetic counseling even more complex. In this context, the main challenge will be to differentiate true oligogenism from situations when several rare variants that do not have a clear phenotypic effect are identified by chance. This review aims to summarize the genetics of CHH/KS and to discuss the challenges of oligogenic transmission and also its role in incomplete penetrance and variable expressivity in a perspective of genetic counseling.
[Mh] Termos MeSH primário: Aconselhamento Genético
Hipogonadismo/genética
Infertilidade/genética
Síndrome de Kallmann/genética
Herança Multifatorial/genética
[Mh] Termos MeSH secundário: Sequenciamento de Nucleotídeos em Larga Escala
Seres Humanos
Hipogonadismo/congênito
Penetrância
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180114
[St] Status:MEDLINE
[do] DOI:10.1530/EJE-17-0749


  4 / 9556 MEDLINE  
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[PMID]:29216611
[Au] Autor:Biundo B
[Ad] Endereço:Professional Compounding Centers of America, Houston, Texas. bbiundo@pccarx.com.
[Ti] Título:Compounding Opportunities in Urology.
[So] Source:Int J Pharm Compd;21(5):358-362, 2017 Sep-Oct.
[Is] ISSN:1092-4221
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There are a lot of options that pharmacists, including compounding pharmacists, can offer urologists to assist their patients. Compounding pharmacists are in a great position to offer unique, effective preparations for many of the conditions urologists treat on a daily basis. It would be well worth the time to learn a little about the conditions these specialists treat and become familiar with what you can offer.
[Mh] Termos MeSH primário: Composição de Medicamentos
Farmacêuticos
Urologia
[Mh] Termos MeSH secundário: Cistite Intersticial/tratamento farmacológico
Disfunção Erétil/tratamento farmacológico
Seres Humanos
Infertilidade/tratamento farmacológico
Masculino
Dor Pélvica/tratamento farmacológico
Induração Peniana/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE


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[PMID]:27778517
[Au] Autor:Hammarberg K; Zosel R; Comoy C; Robertson S; Holden C; Deeks M; Johnson L
[Ad] Endereço:a Victorian Assisted Reproductive Treatment Authority , Melbourne , Victoria , Australia.
[Ti] Título:Fertility-related knowledge and information-seeking behaviour among people of reproductive age: a qualitative study.
[So] Source:Hum Fertil (Camb);20(2):88-95, 2017 Jun.
[Is] ISSN:1742-8149
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Some potentially modifiable factors adversely affect fertility and pregnancy health. To inform a fertility health promotion programme, this study investigated fertility knowledge and information-seeking behaviour among people of reproductive age. This was a qualitative study involving six focus group discussions with women and men who intended to have children in the future and eight paired interviews with couples who were actively trying to conceive. Participants (n = 74) themselves generally claimed 'low' to 'average' levels of knowledge about fertility. Most of them overestimated women's reproductive lifespan and had limited knowledge about the 'fertile window' of the menstrual cycle. The Internet was a common source of fertility-related information and social media was viewed as a potential effective avenue for dissemination of messages about fertility and how to protect it. Most participants agreed that primary health care providers, such as general practitioners (GPs), are well placed to provide information regarding fertility and pregnancy health. This study identified several gaps in knowledge among people of reproductive age about factors that influence fertility and pregnancy health negatively. Addressing these knowledge gaps in school curricula, primary care and health promotion would assist people to realize their reproductive goals and reduce the risk of infertility and adverse obstetric outcomes.
[Mh] Termos MeSH primário: Fertilidade
Conhecimentos, Atitudes e Prática em Saúde
Infertilidade
Comportamento de Busca de Informação
Reprodução/fisiologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Grupos Focais
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1080/14647273.2016.1245447


  6 / 9556 MEDLINE  
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[PMID]:29314805
[Au] Autor:Radojcic L; Divac-Jovanovic M
[Ti] Título:Redefinition of gender roles and fertility problems.
[So] Source:Vojnosanit Pregl;73(7):690-4, 2016 Jul.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Mh] Termos MeSH primário: Cultura
Identidade de Gênero
Infertilidade/psicologia
Casamento/psicologia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Infertilidade/terapia
Masculino
Sérvia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE


  7 / 9556 MEDLINE  
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[PMID]:28470451
[Au] Autor:Collins SC
[Ad] Endereço:Division of Reproductive Endocrinology and Infertility, Yale School of Medicine, 150 Sargent Drive, Second Floor, New Haven, CT, 06511, USA. Stephen.c.collins@yale.edu.
[Ti] Título:Precision reproductive medicine: multigene panel testing for infertility risk assessment.
[So] Source:J Assist Reprod Genet;34(8):967-973, 2017 Aug.
[Is] ISSN:1573-7330
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The concept of precision medicine relies on a thorough understanding of the consequences of unique features of individual patients, such as environmental exposures and genetic profiles. A key component of implementing individualized care in this paradigm will be improved assessment of genetic risk. Compared with single gene tests, multigene panel testing-which has recently become commercially available for female infertility-offers the possibility of a more comprehensive and efficient risk evaluation. However, as the use of multigene panel testing for breast cancer risk has shown, this approach must be used judiciously to ensure its usefulness in a clinical setting. Key challenges which have been encountered in oncology include the interpretation of gene variants of questionable clinical effect and a lack of evidence to guide management after variants are identified. In this review, the core concepts of multigene panel testing for risk assessment are discussed, with careful attention to both its shortcomings as well as its potential for benefit in reproductive medicine.
[Mh] Termos MeSH primário: Infertilidade/genética
[Mh] Termos MeSH secundário: Testes Genéticos/métodos
Seres Humanos
Medicina Reprodutiva/métodos
Medição de Risco/métodos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1007/s10815-017-0938-y


  8 / 9556 MEDLINE  
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[PMID]:29179273
[Au] Autor:Zhao H; Teng XM; Li YF
[Ad] Endereço:Center of Reproductive Medicine, Henan Province People's Hospital, Zhengzhou 450003, China.
[Ti] Título:[Relationship between mitochondrial DNA copy number, membrane potential of human embryo and embryo morphology].
[So] Source:Zhonghua Fu Chan Ke Za Zhi;52(11):770-774, 2017 Nov 25.
[Is] ISSN:0529-567X
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To explore the relationship between the embryo with the different morphological types in the third day and its mitochondrial copy number, the membrane potential. Totally 117 embryos with poor development after normal fertilization and were not suitable transferred in the fresh cycle and 106 frozen embryos that were discarded voluntarily by infertility patients with in vitro fertilization-embryo transfer after successful pregnancy were selected. According to evaluation of international standard in embryos, all cleavage stage embryos were divided into class â…  frozen embryo group ( 64), class â…¡ frozen embryo group ( 42) and class â…¢ fresh embryonic group (not transplanted embryos; 117). Real-time PCR and confocal microscopy methods were used to detect mitochondrial DNA (mtDNA) copy number and the mitochondrial membrane potential of a single embryo. The differences between embryo quality and mtDNA copy number and membrane potential of each group were compared. The copy number of mtDNA and the mitochondrial membrane potential in class â…¢ fresh embryonic group [(1.7±1.0)×10(5) copy/µl, 1.56±0.32] were significantly lower than those in class â…  frozen embryo group [(3.4±1.7)×10(5) copy/µl, 2.66±0.21] and class â…¡ frozen embryo group [(2.6±1.2)×10(5) copy/µl, 1.80±0.32; all 0.05]. The copy number of mtDNA and the mitochondrial membrane potential in classâ…  frozen embryo group were significantly higher than those in classâ…¡ frozen embryo group (both 0.05). The mtDNA copy number and the mitochondrial membrane potential of embryos of the better quality embryo are higher.
[Mh] Termos MeSH primário: DNA Mitocondrial
Potenciais da Membrana
[Mh] Termos MeSH secundário: Transferência Embrionária
Feminino
Fertilização In Vitro
Seres Humanos
Infertilidade
Microscopia Confocal
Gravidez
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Mitochondrial)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180111
[Lr] Data última revisão:
180111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-567X.2017.11.010


  9 / 9556 MEDLINE  
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[PMID]:28455086
[Au] Autor:Luke B; Gopal D; Cabral H; Stern JE; Diop H
[Ad] Endereço:Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University, East Lansing, MI. Electronic address: lukeb@msu.edu.
[Ti] Título:Adverse pregnancy, birth, and infant outcomes in twins: effects of maternal fertility status and infant gender combinations; the Massachusetts Outcomes Study of Assisted Reproductive Technology.
[So] Source:Am J Obstet Gynecol;217(3):330.e1-330.e15, 2017 09.
[Is] ISSN:1097-6868
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: It is unknown whether the risk of adverse outcomes in twin pregnancies among subfertile women, conceived with and without in vitro fertilization, differs from those conceived spontaneously. OBJECTIVE: We sought to evaluate the effects of fertility status on adverse perinatal outcomes in twin pregnancies on a population basis. STUDY DESIGN: All twin live births of ≥22 weeks' gestation and ≥350 g birthweight to Massachusetts resident women in 2004 through 2010 were linked to hospital discharge records, vital records, and in vitro fertilization cycles. Women were categorized by their fertility status as in vitro fertilization, subfertile, or fertile, and by twin pair genders (all, like, unlike). Women whose births linked to in vitro fertilization cycles were classified as in vitro fertilization; those with indicators of subfertility but without in vitro fertilization treatment were classified as subfertile; all others were classified as fertile. Risks of 6 adverse pregnancy outcomes (gestational diabetes, pregnancy hypertension, uterine bleeding, placental complications [placenta abruptio, placenta previa, and vasa previa], prenatal hospitalizations, and primary cesarean) and 9 adverse infant outcomes (very low birthweight, low birthweight, small-for-gestation birthweight, large-for-gestation birthweight, very preterm [<32 weeks], preterm, birth defects, neonatal death, and infant death) were modeled by fertility status with the fertile group as reference, using multivariate log binomial regression and reported as adjusted relative risk ratios and 95% confidence intervals. RESULTS: The study population included 10,352 women with twin pregnancies (6090 fertile, 724 subfertile, and 3538 in vitro fertilization). Among all twins, the risks for all 6 adverse pregnancy outcomes were significantly increased for the subfertile and in vitro fertilization groups, with highest risks for uterine bleeding (adjusted relative risk ratios, 1.92 and 2.58, respectively) and placental complications (adjusted relative risk ratios, 2.07 and 1.83, respectively). Among all twins, the risks for those born to subfertile women were significantly increased for very preterm birth and neonatal and infant death (adjusted relative risk ratios, 1.36, 1.89, and 1.87, respectively). Risks were significantly increased among in vitro fertilization twins for very preterm birth, preterm birth, and birth defects (adjusted relative risk ratios, 1.28, 1.07, and 1.26, respectively). CONCLUSION: Risks of all maternal and most infant adverse outcomes were increased for subfertile and in vitro fertilization twins. Among all twins, the highest risks were for uterine bleeding and placental complications for the subfertile and in vitro fertilization groups, and neonatal and infant death in the subfertile group. These findings provide further evidence supporting single embryo transfer and more cautious use of ovulation induction.
[Mh] Termos MeSH primário: Fertilização In Vitro
Infertilidade
Gravidez de Gêmeos
[Mh] Termos MeSH secundário: Adulto
Apresentação Pélvica/epidemiologia
Cesárea/estatística & dados numéricos
Anormalidades Congênitas/epidemiologia
Feminino
Seres Humanos
Recém-Nascido de Baixo Peso
Masculino
Massachusetts/epidemiologia
Doenças Placentárias/epidemiologia
Gravidez
Nascimento Prematuro/epidemiologia
Transferência de Embrião Único
Hemorragia Uterina/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180111
[Lr] Data última revisão:
180111
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


  10 / 9556 MEDLINE  
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[PMID]:29284224
[Au] Autor:Skrzypek M; Wdowiak A; Marzec A
[Ad] Endereço:Department of Clinical Dietetics, Faculty of Health Sciences, Medical University, Lublin, Poland. michal.skrzypek@umlub.pl.
[Ti] Título:Application of dietetics in reproductive medicine.
[So] Source:Ann Agric Environ Med;24(4):559-565, 2017 Dec 23.
[Is] ISSN:1898-2263
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:In the light of up-to-date epidemiological data concerning the prevalence of infertility, and also considering the scale of the problem of obesity and proven cause-effect relationship between abnormal body weight and infertility, it is justifiable to undertake the task of systematization of the state of knowledge concerning nutritional correlates of infertility, in order to create a scientific basis for the formulation of the assumptions of a fertility diet. The study is an attempt to systematize the current state of knowledge concerning the importance of energy and structural (qualitative) aspects of nutrition in the prevention and treatment of infertility.
[Mh] Termos MeSH primário: Dietética/métodos
Infertilidade/dietoterapia
Medicina Reprodutiva/métodos
[Mh] Termos MeSH secundário: Animais
Dietética/tendências
Seres Humanos
Infertilidade/metabolismo
Estado Nutricional
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171230
[St] Status:MEDLINE



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