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Pesquisa : C12.294.565 [Categoria DeCS]
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[PMID]:29489699
[Au] Autor:Qiu Y; Liu Y; Ren W; Ren J
[Ad] Endereço:Department of General Practice, the First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
[Ti] Título:Prostatic cyst in general practice: A case report and literature review.
[So] Source:Medicine (Baltimore);97(9):e9985, 2018 Mar.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Prostatic cyst is a rare disease of the prostate especially in general practice. As it is often asymptomatic, how to manage it is still unfamiliar with, general practitioners (GPs). PATIENT CONCERNS: The 24-year-old man presented with left back discomfort for 1 week without severe pain, dysuria, or fever. DIAGNOSES: Ultrasonography revealed the presence of a 14×14 mm cystic lesion. INTERVENTIONS: The patient was given the medicine and regular follow-up. OUTCOMES: Several days later, he recovered without lower back discomfort. LESSONS: Patients with prostatic cyst of small size and no symptom should be follow-up regularly. Although prostatic cyst of progressive symptoms, large size (2.5 cm or larger), or high serum prostate-specific antigen (PSA) should be timely referred to urological specialists.
[Mh] Termos MeSH primário: Cistos/complicações
Medicina Geral/métodos
Dor Lombar/etiologia
Doenças Prostáticas/complicações
[Mh] Termos MeSH secundário: Cistos/diagnóstico por imagem
Seres Humanos
Dor Lombar/diagnóstico por imagem
Masculino
Doenças Prostáticas/diagnóstico por imagem
Ultrassonografia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180301
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009985


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[PMID]:28931070
[Au] Autor:McBirney M; King SE; Pappalardo M; Houser E; Unkefer M; Nilsson E; Sadler-Riggleman I; Beck D; Winchester P; Skinner MK
[Ad] Endereço:Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, Washington, United States of America.
[Ti] Título:Atrazine induced epigenetic transgenerational inheritance of disease, lean phenotype and sperm epimutation pathology biomarkers.
[So] Source:PLoS One;12(9):e0184306, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ancestral environmental exposures to a variety of environmental toxicants and other factors have been shown to promote the epigenetic transgenerational inheritance of adult onset disease. The current study examined the potential transgenerational actions of the herbicide atrazine. Atrazine is one of the most commonly used herbicides in the agricultural industry, in particular with corn and soy crops. Outbred gestating female rats were transiently exposed to a vehicle control or atrazine. The F1 generation offspring were bred to generate the F2 generation and then the F2 generation bred to generate the F3 generation. The F1, F2 and F3 generation control and atrazine lineage rats were aged and various pathologies investigated. The male sperm were collected to investigate DNA methylation differences between the control and atrazine lineage sperm. The F1 generation offspring (directly exposed as a fetus) did not develop disease, but weighed less compared to controls. The F2 generation (grand-offspring) was found to have increased frequency of testis disease and mammary tumors in males and females, early onset puberty in males, and decreased body weight in females compared to controls. The transgenerational F3 generation rats were found to have increased frequency of testis disease, early onset puberty in females, behavioral alterations (motor hyperactivity) and a lean phenotype in males and females. The frequency of multiple diseases was significantly higher in the transgenerational F3 generation atrazine lineage males and females. The transgenerational transmission of disease requires germline (egg or sperm) epigenetic alterations. The sperm differential DNA methylation regions (DMRs), termed epimutations, induced by atrazine were identified in the F1, F2 and F3 generations. Gene associations with the DMRs were identified. For the transgenerational F3 generation sperm, unique sets of DMRs (epimutations) were found to be associated with the lean phenotype or testis disease. These DMRs provide potential biomarkers for transgenerational disease. The etiology of disease appears to be in part due to environmentally induced epigenetic transgenerational inheritance, and epigenetic biomarkers may facilitate the diagnosis of the ancestral exposure and disease susceptibility. Observations indicate that although atrazine does not promote disease in the directly exposed F1 generation, it does have the capacity to promote the epigenetic transgenerational inheritance of disease.
[Mh] Termos MeSH primário: Atrazina/toxicidade
Biomarcadores/metabolismo
Epigênese Genética/efeitos dos fármacos
Herbicidas/toxicidade
Espermatozoides/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adipócitos/citologia
Adipócitos/patologia
Animais
Comportamento Animal/efeitos dos fármacos
Peso Corporal/efeitos dos fármacos
Metilação de DNA
Feminino
Nefropatias/epidemiologia
Nefropatias/etiologia
Masculino
Doenças Metabólicas/epidemiologia
Doenças Metabólicas/etiologia
Fenótipo
Doenças Prostáticas/epidemiologia
Doenças Prostáticas/etiologia
Ratos
Ratos Sprague-Dawley
Maturidade Sexual/efeitos dos fármacos
Espermatozoides/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Herbicides); QJA9M5H4IM (Atrazine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170921
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184306


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[PMID]:28904679
[Au] Autor:Ojewola RW; Oridota ES; Balogun OS; Ogundare EO; Alabi TO; Banjo OO; Laoye A; Adetunmbi B; Adebayo BO; Oluyombo R
[Ad] Endereço:Department of Surgery, College of Medicine of University of Lagos/Lagos University Teaching Hospital, PMB 12003, Idi-Araba, Surulere, Lagos, Nigeria.
[Ti] Título:Knowledge, attitudes and screening practices regarding prostatic diseases among men older than 40 years: a population-based study in Southwest Nigeria.
[So] Source:Pan Afr Med J;27:151, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Despite the global increase in awareness of prostatic diseases resulting from widespread availability of screening tools, there is no evidence that the knowledge, attitudes and screening practices of Nigerian men have improved regarding prostatic diseases. METHODS: A descriptive cross-sectional study amongst 305 community-dwelling men. Respondents were selected using multi-staged sampling techniques. Knowledge, attitudes and screening practices were determined based on responses to a semi-structured KAP questionnaire. Data were analyzed using SPSS version 18. Pearson's chi-square and Fisher's exact test (two-tail) with level of significance set at 0.05 were used to determine the level of statistical significance. Pearson's correlation coefficient was used to establish correlation between variables. RESULTS: Mean age of respondents was 63.4±11.8 years. Slightly less than half, 145(47.5%) were aware of prostate cancer (PCa) while only 99(32.5%) and 91(29.8%) were aware of BPH and prostatitis respectively. About a quarter (25.1%) had heard of PSA. The main sources of information were radio and television. Overall, 143(46.9%) respondents had good knowledge while 162(53.1%) had poor knowledge. Sexually transmitted disease was the commonest misconception as the cause of prostatic diseases. Overall, 44.3% had good attitudes. Only 31(10.2%) respondents had ever carried out screening for PCa. Only educational and occupational status had significant associations with level of knowledge and attitudes of participants. The only factor that influenced screening practices was educational status. CONCLUSION: There is a poor level of knowledge, attitudes and screening practices regarding prostatic diseases in Nigeria. We recommend a widespread public health education to improve knowledge, attitudes and screening practices for prostatic diseases.
[Mh] Termos MeSH primário: Conhecimentos, Atitudes e Prática em Saúde
Programas de Rastreamento/estatística & dados numéricos
Doenças Prostáticas/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Estudos Transversais
Seres Humanos
Masculino
Meia-Idade
Nigéria
Doenças Prostáticas/diagnóstico
Doenças Prostáticas/etiologia
Hiperplasia Prostática/diagnóstico
Hiperplasia Prostática/fisiopatologia
Neoplasias da Próstata/diagnóstico
Neoplasias da Próstata/fisiopatologia
Prostatite/diagnóstico
Prostatite/fisiopatologia
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.151.10605


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[PMID]:28844848
[Au] Autor:Shahin NN; Mohamed MM
[Ad] Endereço:Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt. Electronic address: nancy.shahin@pharma.cu.edu.eg.
[Ti] Título:Nano-sized titanium dioxide toxicity in rat prostate and testis: Possible ameliorative effect of morin.
[So] Source:Toxicol Appl Pharmacol;334:129-141, 2017 Nov 01.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study investigated the effect of short-term oral exposure to nano-sized titanium dioxide (nTiO ) on Wistar rat prostate and testis, and the associating reproductive-related alterations. The study also evaluated the potential ameliorative effect of the natural flavonoid, morin, on nTiO -induced aberrations. Intragastric administration of nTiO (50mg/kg/day for 1, 2 and 3weeks) increased testicular gamma-glutamyltransferase (γ-GT) activity and decreased testicular steroidogenic acute regulatory protein (StAR) and c-kit gene expression, serum testosterone level and sperm count. nTiO -treated rats also exhibited prostatic and testicular altered glutathione levels, elevated TNF-α levels, up-regulated Fas, Bax and caspase-3 gene expression, down-regulated Bcl-2 gene expression and enhanced prostatic lipid peroxidation. Sperm malformation and elevated testicular acid phosphatase (ACP) activity and malondialdehyde level, serum prostatic acid phosphatase activity, prostate specific antigen (PSA), gonadotrophin and estradiol levels occurred after the 2 and 3week regimens. Morin (30mg/kg/day administered intragastrically for 5weeks) mitigated nTiO -induced prostatic and testicular injury as evidenced by lowering serum PSA level, testicular γ-GT and ACP activities and TNF-α level, along with hampering both intrinsic and extrinsic apoptotic pathways. Moreover, morin alleviated prostatic lipid peroxidation, raised prostatic glutathione level, and relieved testicular reductive stress. Additionally, morin increased testicular StAR and c-kit mRNA expression, raised the sperm count, reduced sperm deformities and modified the altered hormone profile. Histopathological evaluation supported the biochemical findings. In conclusion, morin could ameliorate nTiO -induced prostatic and testicular injury and the corresponding reproductive-related aberrations via redox regulatory, anti-inflammatory and anti-apoptotic mechanisms, promoting steroidogenesis and spermatogenesis, and improving sperm count and morphology.
[Mh] Termos MeSH primário: Flavonoides/uso terapêutico
Nanopartículas Metálicas/toxicidade
Próstata/efeitos dos fármacos
Testículo/efeitos dos fármacos
Titânio/toxicidade
[Mh] Termos MeSH secundário: Animais
Antioxidantes/administração & dosagem
Antioxidantes/uso terapêutico
Biomarcadores
Flavonoides/administração & dosagem
Regulação da Expressão Gênica/efeitos dos fármacos
Masculino
Nanopartículas Metálicas/química
Estresse Oxidativo/efeitos dos fármacos
Próstata/patologia
Doenças Prostáticas/induzido quimicamente
Doenças Prostáticas/tratamento farmacológico
Proteínas Proto-Oncogênicas c-kit/genética
Proteínas Proto-Oncogênicas c-kit/metabolismo
Distribuição Aleatória
Ratos
Ratos Wistar
Contagem de Espermatozoides
Doenças Testiculares/induzido quimicamente
Doenças Testiculares/tratamento farmacológico
Testículo/patologia
Titânio/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biomarkers); 0 (Flavonoids); 15FIX9V2JP (titanium dioxide); 8NFQ3F76WR (morin); D1JT611TNE (Titanium); EC 2.7.10.1 (Proto-Oncogene Proteins c-kit)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE


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[PMID]:28699177
[Au] Autor:Wang K; Chen X; Bird VY; Gerke TA; Manini TM; Prosperi M
[Ad] Endereço:Department of Epidemiology, University of Florida, Gainesville, FL.
[Ti] Título:Association between age-related reductions in testosterone and risk of prostate cancer-An analysis of patients' data with prostatic diseases.
[So] Source:Int J Cancer;141(9):1783-1793, 2017 Nov 01.
[Is] ISSN:1097-0215
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The relationship between serum total testosterone and prostate cancer (PCa) risk is controversial. The hypothesis that faster age-related reduction in testosterone is linked with increased PCa risk remains untested. We conducted our study at a tertiary-level hospital in southeast of the USA, and derived data from the Medical Registry Database of individuals that were diagnosed of any prostate-related disease from 2001 to 2015. Cases were those diagnosed of PCa and had one or more measurements of testosterone prior to PCa diagnosis. Controls were those without PCa and had one or more testosterone measurements. Multivariable logistic regression models for PCa risk of absolute levels (one-time measure and 5-year average) and annual change in testosterone were respectively constructed. Among a total of 1,559 patients, 217 were PCa cases, and neither one-time measure nor 5-year average of testosterone was found to be significantly associated with PCa risk. Among the 379 patients with two or more testosterone measurements, 27 were PCa cases. For every 10 ng/dL increment in annual reduction of testosterone, the risk of PCa would increase by 14% [adjusted odds ratio, 1.14; 95% confidence interval (CI), 1.03-1.25]. Compared to patients with a relatively stable testosterone, patients with an annual testosterone reduction of more than 30 ng/dL had 5.03 [95% CI: 1.53, 16.55] fold increase in PCa risk. This implies a faster age-related reduction in, but not absolute level of serum total testosterone as a risk factor for PCa. Further longitudinal studies are needed to confirm this finding.
[Mh] Termos MeSH primário: Doenças Prostáticas/sangue
Neoplasias da Próstata/sangue
Testosterona/sangue
[Mh] Termos MeSH secundário: Fatores Etários
Idoso
Biópsia
Seres Humanos
Masculino
Meia-Idade
Próstata/patologia
Antígeno Prostático Específico/sangue
Doenças Prostáticas/patologia
Neoplasias da Próstata/patologia
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
3XMK78S47O (Testosterone); EC 3.4.21.77 (Prostate-Specific Antigen)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1002/ijc.30882


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[PMID]:28539434
[Au] Autor:Cooke PS; Nanjappa MK; Ko C; Prins GS; Hess RA
[Ad] Endereço:Department of Physiological Sciences, University of Florida, Gainesville, Florida; Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, Illinois; Department of Urology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois.
[Ti] Título:Estrogens in Male Physiology.
[So] Source:Physiol Rev;97(3):995-1043, 2017 Jul 01.
[Is] ISSN:1522-1210
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Estrogens have historically been associated with female reproduction, but work over the last two decades established that estrogens and their main nuclear receptors (ESR1 and ESR2) and G protein-coupled estrogen receptor (GPER) also regulate male reproductive and nonreproductive organs. 17ß-Estradiol (E2) is measureable in blood of men and males of other species, but in rete testis fluids, E2 reaches concentrations normally found only in females and in some species nanomolar concentrations of estrone sulfate are found in semen. Aromatase, which converts androgens to estrogens, is expressed in Leydig cells, seminiferous epithelium, and other male organs. Early studies showed E2 binding in numerous male tissues, and ESR1 and ESR2 each show unique distributions and actions in males. Exogenous estrogen treatment produced male reproductive pathologies in laboratory animals and men, especially during development, and studies with transgenic mice with compromised estrogen signaling demonstrated an E2 role in normal male physiology. Efferent ductules and epididymal functions are dependent on estrogen signaling through ESR1, whose loss impaired ion transport and water reabsorption, resulting in abnormal sperm. Loss of ESR1 or aromatase also produces effects on nonreproductive targets such as brain, adipose, skeletal muscle, bone, cardiovascular, and immune tissues. Expression of GPER is extensive in male tracts, suggesting a possible role for E2 signaling through this receptor in male reproduction. Recent evidence also indicates that membrane ESR1 has critical roles in male reproduction. Thus estrogens are important physiological regulators in males, and future studies may reveal additional roles for estrogen signaling in various target tissues.
[Mh] Termos MeSH primário: Estrogênios/metabolismo
Genitália Masculina/metabolismo
Receptores Estrogênicos/metabolismo
Reprodução
[Mh] Termos MeSH secundário: Animais
Aromatase/genética
Aromatase/metabolismo
Genitália Masculina/patologia
Genitália Masculina/fisiopatologia
Genótipo
Seres Humanos
Masculino
Camundongos Knockout
Mutação
Fenótipo
Próstata/metabolismo
Próstata/patologia
Próstata/fisiopatologia
Doenças Prostáticas/metabolismo
Doenças Prostáticas/patologia
Doenças Prostáticas/fisiopatologia
Receptores Estrogênicos/deficiência
Receptores Estrogênicos/genética
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Estrogens); 0 (Receptors, Estrogen); EC 1.14.14.1 (Aromatase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1152/physrev.00018.2016


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[PMID]:28482833
[Au] Autor:Kuhnt NSM; Harder LK; Nolte I; Wefstaedt P
[Ad] Endereço:Small Animal Clinic, University of Veterinary Medicine Hannover, Foundation, Hannover, Bünteweg 9, D-30559, Hannover, Germany.
[Ti] Título:Computed tomography: a beneficial diagnostic tool for the evaluation of the canine prostate?
[So] Source:BMC Vet Res;13(1):123, 2017 May 08.
[Is] ISSN:1746-6148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Prostatic diseases in intact male dogs are common. However, studies about the computed tomographic (CT) examination of the prostate in dogs are rare. The aim of the present study was to evaluate age related-changes in the canine prostate with the help of the CT and to evaluate whether measuring Hounsfield Units (HUs) in different morphological conditions of the prostate is of diagnostic value. Fifty pre- and post-contrast CT scans of the prostate of dogs were evaluated and divided into three groups according to the tissue structure: Group1 dogs with homogenous prostate tissue (16/50); group 2 with prostate cysts (26/50) and group 3 with inhomogeneous prostate tissue (8/50). The prostatic dimensions were measured and the ratio between length, height and width and the sixth lumbar vertebra was calculated. Median values of prostatic attenuation measured in HUs, using regions of interests (ROIs) were determined on pre- and post- contrast scans over the whole length of the prostate. The results were compared to the dog's age. Furthermore, the CT Images were compared with the results of ultrasonography (47/50). RESULTS: On pre-contrast scans HUs within ROIs placed in the prostate did not differ statistically significantly between the different morphological groups (1: 37.7; 2: 36.3; 3: 39.8 HU). HUs within on the post- contrast scans showed statistically significant differences between the groups. Group one had a mean density of 93.6 HU, group two had a mean density of 106.1 HU and group three had one of 138.2 HU. The prostatic size in the first group was smaller than in the other groups, whereas the largest prostates were found in the second group. In six cases the post-contrast CT scan showed results that differed from the ultrasound examination. Dogs had a homogenous tissue in ultrasonography while the CT scan revealed an inhomogeneous tissue structure. CONCLUSIONS: The CT examination can be a beneficial diagnostic tool for examining the prostatic size and for evaluating the prostatic tissue. The different HUs reflected age-related changes and alterations in the prostate while measuring the density of the prostate. Contrast agent application enables a more specific analysis of the prostate to be carried out and for precise changes in tissue structure to be observed.
[Mh] Termos MeSH primário: Próstata/diagnóstico por imagem
Doenças Prostáticas/veterinária
Tomografia Computadorizada por Raios X/veterinária
[Mh] Termos MeSH secundário: Fatores Etários
Animais
Cães
Masculino
Tamanho do Órgão
Doenças Prostáticas/diagnóstico por imagem
Ultrassonografia/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170510
[St] Status:MEDLINE
[do] DOI:10.1186/s12917-017-1016-5


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[PMID]:28428477
[Au] Autor:Shiina H
[Ti] Título:1. Making a Diagnosis of Prostatic Disorders Based on the Recent Imaging Procedures.
[So] Source:Nihon Hoshasen Gijutsu Gakkai Zasshi;73(4):330-339, 2017.
[Is] ISSN:0369-4305
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Mh] Termos MeSH primário: Doenças Prostáticas/diagnóstico por imagem
[Mh] Termos MeSH secundário: Seres Humanos
Masculino
Guias de Prática Clínica como Assunto
Prognóstico
Doenças Prostáticas/diagnóstico
Recidiva
Fatores de Risco
Ultrassonografia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE
[do] DOI:10.6009/jjrt.2017_JSRT_73.4.330


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[PMID]:28428476
[Au] Autor:Uchida K
[Ti] Título:Preface.
[So] Source:Nihon Hoshasen Gijutsu Gakkai Zasshi;73(4):329, 2017.
[Is] ISSN:0369-4305
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Mh] Termos MeSH primário: Doenças Prostáticas/diagnóstico por imagem
[Mh] Termos MeSH secundário: Seres Humanos
Masculino
Doenças Prostáticas/terapia
[Pt] Tipo de publicação:INTRODUCTORY JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE
[do] DOI:10.6009/jjrt.2017_JSRT_73.4.329


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[PMID]:28415915
[Au] Autor:Adamama-Moraitou KK; Pardali D; Prassinos NN; Menexes G; Patsikas MN; Rallis TS
[Ad] Endereço:a School of Veterinary Medicine, Faculty of Health Sciences , Aristotle University of Thessaloniki , St. Voutira 11 str., 54627 Thessaloniki , Greece.
[Ti] Título:Evaluation of dogs with macroscopic haematuria: a retrospective study of 162 cases (2003-2010).
[So] Source:N Z Vet J;65(4):204-208, 2017 Jul.
[Is] ISSN:1176-0710
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: To retrospectively describe clinical features of dogs that were presented to a small animal clinic between 2003-10 with macroscopic haematuria, and investigate whether signalment of the dog and severity and duration of the haematuria at admission were associated with specific aetiologies. METHODS: Medical records were evaluated of 162 dogs with macroscopic haematuria admitted to a University-based small animal clinic in Thessaloniki, Greece, from January 2003 to December 2010. The inclusion criteria were discolouration of the urine sediment combined with abnormal numbers of erythrocytes, when examined microscopically. Data collected from the medical records included signalment, severity, frequency and duration of haematuria, and diagnosis. RESULTS: Between January 2007 and December 2010, 8,893 dogs were admitted to the clinic; of these 99 (1.1%) were admitted with haematuria. Of the 162 dogs with records of haematuria, 80 (49.4%) were aged between 5.1-10 years, presented with acute (96/162; 59.3%), constant (99/162; 61.1%) and mild/moderate (150/162; 92.6%) haematuria. Of 147 dogs with a recorded diagnosis, the commonest diagnoses were urinary tract infection (UTI, 42/147; 28.6%), urolithiasis (38/147; 25.9%), prostatic disease (25/147; 17.0%) and urinary tumours (13/147; 8.8%). The prevalence of UTI was higher in female (22/56; 39%) than male (20/91; 22%) dogs, and in medium sized (22/52; 42%) than small (6/40; 15%) dogs. Urolithiasis was most prevalent in small (21/40; 52.5%) dogs, and all dogs with urolithiasis presented with mild/moderate haematuria. The prevalence of prostatic disease was highest in large (11/46; 24%) and giant (3/9; 33%) sized dogs and in dogs aged >10 years (8/30; 27%). CONCLUSIONS AND CLINICAL RELEVANCE: In this retrospective study from one small animal clinic, UTI, urolithiasis, prostatic disease and urinary tumours predominated among the causes of canine haematuria. The consideration of sex, age, and size of the dog and characteristics of haematuria were found to be useful parameters when forming the list of differential diagnoses.
[Mh] Termos MeSH primário: Doenças do Cão/epidemiologia
Hematúria/veterinária
[Mh] Termos MeSH secundário: Animais
Cães
Feminino
Grécia/epidemiologia
Hematúria/epidemiologia
Hematúria/etiologia
Masculino
Método de Monte Carlo
Doenças Prostáticas/epidemiologia
Doenças Prostáticas/veterinária
Estudos Retrospectivos
Distribuição por Sexo
Infecções Urinárias/epidemiologia
Infecções Urinárias/veterinária
Urolitíase/epidemiologia
Urolitíase/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1080/00480169.2017.1316529



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