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[PMID]:29183799
[Au] Autor:Xing JS; Bai ZM
[Ad] Endereço:Department of Urinary Surgery, Central South University Xiangya School of Medicine Affiliated Haikou Hospital(Haikou People's Hospital), Haikou 570208, PR China.
[Ti] Título:Is testicular dysgenesis syndrome a genetic, endocrine, or environmental disease, or an unexplained reproductive disorder?
[So] Source:Life Sci;194:120-129, 2018 Feb 01.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Progressive increases in the incidence of male reproductive disorders inclusive of hypospadias, cryptorchidism, poor semen quality, and testicular germ cell cancer (TGCC) have been observed in recent times. The central hypothesis of this study asserted that these disorders may all collectively signify testicular dysgenesis syndrome (TDS). This review aimed to provide evidence verifying the reality of TDS based on four key aspects: environmental endocrine-disrupting chemicals (EDCs), genetic factors, intrauterine growth disorders and lifestyle factors. Although TDS might result from genetic polymorphisms or aberration, recent evidence has highlighted links indicating the conditions associations to both environmental and lifestyle factors due to the rapid temporal changes in the clinical symptoms observed over recent decades. Based on our review of genetic and environmental factors, a key observation of our study suggested that there is an urgent need to prioritize research in reproductive physiology and pathophysiology, particularly in highly industrialized countries facing decreasing populations. At present, current research has yet to elucidate the mechanisms of TDS, in addition to the lack of genuine consideration of a variety of potentially key factors and TDS mechanisms. In conclusion, our study revealed that environmental exposures owing to modern lifestyles are primary factors involved in the associated trends of the syndrome, which are capable of affecting the adult endocrine system via direct means or through epigenetic mechanisms.
[Mh] Termos MeSH primário: Disgenesia Gonadal/etiologia
Infertilidade Masculina/etiologia
Doenças Testiculares/etiologia
Testículo/patologia
[Mh] Termos MeSH secundário: Animais
Disruptores Endócrinos/efeitos adversos
Retardo do Crescimento Fetal/genética
Retardo do Crescimento Fetal/patologia
Disgenesia Gonadal/genética
Disgenesia Gonadal/patologia
Seres Humanos
Infertilidade Masculina/genética
Infertilidade Masculina/patologia
Estilo de Vida
Masculino
Neoplasias Embrionárias de Células Germinativas/etiologia
Neoplasias Embrionárias de Células Germinativas/genética
Neoplasias Embrionárias de Células Germinativas/patologia
Polimorfismo Genético
Doenças Testiculares/genética
Doenças Testiculares/patologia
Neoplasias Testiculares/etiologia
Neoplasias Testiculares/genética
Neoplasias Testiculares/patologia
Testículo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Endocrine Disruptors)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE


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[PMID]:28844848
[Au] Autor:Shahin NN; Mohamed MM
[Ad] Endereço:Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt. Electronic address: nancy.shahin@pharma.cu.edu.eg.
[Ti] Título:Nano-sized titanium dioxide toxicity in rat prostate and testis: Possible ameliorative effect of morin.
[So] Source:Toxicol Appl Pharmacol;334:129-141, 2017 Nov 01.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study investigated the effect of short-term oral exposure to nano-sized titanium dioxide (nTiO ) on Wistar rat prostate and testis, and the associating reproductive-related alterations. The study also evaluated the potential ameliorative effect of the natural flavonoid, morin, on nTiO -induced aberrations. Intragastric administration of nTiO (50mg/kg/day for 1, 2 and 3weeks) increased testicular gamma-glutamyltransferase (γ-GT) activity and decreased testicular steroidogenic acute regulatory protein (StAR) and c-kit gene expression, serum testosterone level and sperm count. nTiO -treated rats also exhibited prostatic and testicular altered glutathione levels, elevated TNF-α levels, up-regulated Fas, Bax and caspase-3 gene expression, down-regulated Bcl-2 gene expression and enhanced prostatic lipid peroxidation. Sperm malformation and elevated testicular acid phosphatase (ACP) activity and malondialdehyde level, serum prostatic acid phosphatase activity, prostate specific antigen (PSA), gonadotrophin and estradiol levels occurred after the 2 and 3week regimens. Morin (30mg/kg/day administered intragastrically for 5weeks) mitigated nTiO -induced prostatic and testicular injury as evidenced by lowering serum PSA level, testicular γ-GT and ACP activities and TNF-α level, along with hampering both intrinsic and extrinsic apoptotic pathways. Moreover, morin alleviated prostatic lipid peroxidation, raised prostatic glutathione level, and relieved testicular reductive stress. Additionally, morin increased testicular StAR and c-kit mRNA expression, raised the sperm count, reduced sperm deformities and modified the altered hormone profile. Histopathological evaluation supported the biochemical findings. In conclusion, morin could ameliorate nTiO -induced prostatic and testicular injury and the corresponding reproductive-related aberrations via redox regulatory, anti-inflammatory and anti-apoptotic mechanisms, promoting steroidogenesis and spermatogenesis, and improving sperm count and morphology.
[Mh] Termos MeSH primário: Flavonoides/uso terapêutico
Nanopartículas Metálicas/toxicidade
Próstata/efeitos dos fármacos
Testículo/efeitos dos fármacos
Titânio/toxicidade
[Mh] Termos MeSH secundário: Animais
Antioxidantes/administração & dosagem
Antioxidantes/uso terapêutico
Biomarcadores
Flavonoides/administração & dosagem
Regulação da Expressão Gênica/efeitos dos fármacos
Masculino
Nanopartículas Metálicas/química
Estresse Oxidativo/efeitos dos fármacos
Próstata/patologia
Doenças Prostáticas/induzido quimicamente
Doenças Prostáticas/tratamento farmacológico
Proteínas Proto-Oncogênicas c-kit/genética
Proteínas Proto-Oncogênicas c-kit/metabolismo
Distribuição Aleatória
Ratos
Ratos Wistar
Contagem de Espermatozoides
Doenças Testiculares/induzido quimicamente
Doenças Testiculares/tratamento farmacológico
Testículo/patologia
Titânio/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biomarkers); 0 (Flavonoids); 15FIX9V2JP (titanium dioxide); 8NFQ3F76WR (morin); D1JT611TNE (Titanium); EC 2.7.10.1 (Proto-Oncogene Proteins c-kit)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE


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[PMID]:28715257
[Au] Autor:Trout AT; Chow J; McNamara ER; Darge K; Ramirez Grueso R; Munden M; Rothan SM; Navarro OM; Tijerín Bueno M; Bove KE; Chikwava KR; Heider A; Hicks MJ; Somers GR; Zhang B; Dillman JR
[Ad] Endereço:From the Department of Radiology (A.T.T., J.R.D.) and Divisions of Pathology (K.E.B.) and Biostatistics and Epidemiology (B.Z.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229-3026; Departments of Radiology (J.C.) and Urology (E.R.M.), Boston Children's Hospital
[Ti] Título:Association between Testicular Microlithiasis and Testicular Neoplasia: Large Multicenter Study in a Pediatric Population.
[So] Source:Radiology;285(2):576-583, 2017 Nov.
[Is] ISSN:1527-1315
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose To retrospectively define the strength of association between testicular microlithiasis and testicular neoplasia in a large geographically diverse pediatric population. Materials and Methods Retrospective review of scrotal ultrasonographic (US) examination reports and pathology specimens obtained between January 2000 and May 2014 at six academic pediatric hospitals in North America was performed. Reported cases were reviewed to confirm microlithiasis. Radiology and pathology data bases were searched for pathology-proven testicular tumors (benign or malignant germ cell or stromal tumors). Association strength (risk) was expressed in terms of odds ratios (ORs) with and without adjustment for fixed study site effects based on logistic regression. Results A total of 37 863 individuals underwent scrotal US during the study period. Mean age was 11.1 years ± 4.7 [standard deviation] in boys with microlithiasis and 9.1 years ± 5.9 in boys without microlithiasis (P < .001). Microlithiasis was confirmed in 2.90% of patients (1097 of 37 863; range, 1.61%-5.25% across sites). It was unilateral in 21.97% (241 of 1097) of patients and bilateral in 78.0% (856 of 1097). Tumor was identified in 4.64% (51 of 1097) of boys with microlithiasis and 0.33% (122 of 36 766) of boys without (unadjusted OR, 14.65; 95% confidence interval [CI]: 10.29, 20.84; adjusted OR, 14.19). Malignant germ cell tumors were identified in 2.8% (31 of 1097) of boys with microlithiasis and 0.12% (45 of 36 766) of boys without microlithiasis (unadjusted OR, 17.26; 95% CI: 11.8, 25.25; adjusted OR, 22.37). Sex cord-stromal tumors were identified in 0.46% (five of 1097) of boys with microlithiasis and 0.079% (29 of 36 766) of boys without (unadjusted OR, 5.8; 95% CI: 2.1, 16; adjusted OR, 6.39). Conclusion There is a strong association between testicular microlithiasis and primary testicular neoplasia in this pediatric population. RSNA, 2017.
[Mh] Termos MeSH primário: Cálculos/complicações
Cálculos/epidemiologia
Doenças Testiculares/complicações
Doenças Testiculares/epidemiologia
Neoplasias Testiculares/complicações
Neoplasias Testiculares/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Cálculos/diagnóstico por imagem
Criança
Pré-Escolar
Seres Humanos
Masculino
Razão de Chances
Estudos Retrospectivos
Doenças Testiculares/diagnóstico por imagem
Neoplasias Testiculares/diagnóstico por imagem
Ultrassonografia
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170718
[St] Status:MEDLINE
[do] DOI:10.1148/radiol.2017162625


  4 / 4027 MEDLINE  
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[PMID]:28639925
[Au] Autor:Ma W; Sarasohn D; Zheng J; Vargas HA; Bach A
[Ad] Endereço:1 Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065.
[Ti] Título:Causes of Avascular Hypoechoic Testicular Lesions Detected at Scrotal Ultrasound: Can They Be Considered Benign?
[So] Source:AJR Am J Roentgenol;209(1):110-115, 2017 Jul.
[Is] ISSN:1546-3141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The purposes of this study were to determine the cause of avascular hypoechoic lesions detected at scrotal ultrasound and to assess usefulness of sonographic and clinical features in differentiating benign from malignant etiologic factors. MATERIALS AND METHODS: This retrospective study included 58 patients with avascular hypoechoic lesions detected at testicular ultrasound. The sonographic features recorded were lesion size and margins and presence of peripheral vascularity and focal calcifications. Also recorded were patient age, symptoms, risk factors, lesion palpability, and levels of serum tumor markers. The reference standard was pathologic results or at least 2-year stability documented with serial follow-up ultrasound studies. Features associated with malignant, including burnt-out, lesions and benign lesions were examined by Fisher exact test, Wilcox-on rank sum test, and the generalized estimating equations method for multivariable models. RESULTS: Sixty-three lesions were identified in 58 patients; 40 of the 63 (63.5%) were benign. Patients with malignant lesions had elevated serum tumor marker levels more often than patients who had benign lesions (26.1% versus 5.7%, p = 0.043). The clinical palpability of lesions and history of testicular cancer were not statistically significantly different between patients with malignant and those with benign lesions. Poorly defined margins of a lesion and focal calcification within the lesion were more often found in malignant lesions. Maximal size of a lesion and peripheral vascularity were not associated with either the benign or the malignant nature of a lesion. CONCLUSION: Although most avascular hypoechoic testicular lesions are benign, a substantial proportion are malignant. The ultrasound characteristics of a lesion, the patient's clinical presentation, and serum tumor marker status may be useful in differentiating malignant from benign lesions.
[Mh] Termos MeSH primário: Escroto/diagnóstico por imagem
Doenças Testiculares/diagnóstico por imagem
Doenças Testiculares/patologia
Ultrassonografia/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Biomarcadores Tumorais/sangue
Diagnóstico Diferencial
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Fatores de Risco
Doenças Testiculares/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.2214/AJR.16.17333


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[PMID]:28635608
[Au] Autor:Gomaa AM; Abou Khalil NS; Abdel-Ghani MA
[Ad] Endereço:Department of Medical Physiology, Faculty of Medicine, Assiut University, Assiut, Egypt. asmaagom3a@yahoo.com.
[Ti] Título:The protective role of folic acid against testicular dysfunction in lead-intoxicated rat model.
[So] Source:Gen Physiol Biophys;36(3):297-308, 2017 Jul.
[Is] ISSN:0231-5882
[Cp] País de publicação:Slovakia
[La] Idioma:eng
[Ab] Resumo:There is an increasing concern over male reproductive toxicity caused by lead exposure. Folic acid (FA) is supposed to be a promising therapeutic strategy against lead toxicity. Therefore, the aim of this experimental study was to shed light on the potential protective role of FA on lead-induced testicular dysfunction in rats and its possible underlying mechanistic pathways. Rats (n = 24) were divided into four groups: Control, FA, Lead, and FA+Lead group. After 4 weeks, lead intoxication resulted in a marked reduction in the relative testicular weight and the serum level of testosterone, an impairment in the characters of semen analysis, and an increased content of lead, malondialdehyde and both interleukin-6 and -10 and a decreased antioxidant enzyme levels in the testicular tissue homogenate. Furthermore, marked degenerative histological changes and an increased expression of NF-κB were also noticed in the testicular tissue of Lead group. Supplementation of FA in association with lead considerably alleviated these adverse outcome responses most probably owing to its cytoprotective ability as emerged from combating the oxidative stress and inflammatory reactions. We concluded that FA could act as a highly effective fighting approach against lead-associated testicular toxicity.
[Mh] Termos MeSH primário: Ácido Fólico/administração & dosagem
Intoxicação por Chumbo/tratamento farmacológico
Intoxicação por Chumbo/fisiopatologia
Doenças Testiculares/prevenção & controle
Doenças Testiculares/fisiopatologia
Testosterona/sangue
[Mh] Termos MeSH secundário: Animais
Citoproteção/efeitos dos fármacos
Intoxicação por Chumbo/patologia
Masculino
Ratos
Ratos Wistar
Análise do Sêmen
Espermatozoides/efeitos dos fármacos
Espermatozoides/patologia
Doenças Testiculares/induzido quimicamente
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
3XMK78S47O (Testosterone); 935E97BOY8 (Folic Acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170622
[St] Status:MEDLINE
[do] DOI:10.4149/gpb_2016048


  6 / 4027 MEDLINE  
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[PMID]:28496042
[Au] Autor:Miura N; Ohtani K; Hasegawa T; Yoshioka H; Hwang GW
[Ad] Endereço:Industrial Toxicology and Health Effects Research Group, National Institute of Occupational Safety and Health Japan.
[Ti] Título:High sensitivity of testicular function to titanium nanoparticles.
[So] Source:J Toxicol Sci;42(3):359-366, 2017.
[Is] ISSN:1880-3989
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Titanium dioxide nanoparticles (TiNPs) present toxicity in organs such as the liver, lung, and intestine. The testis has also been reported as a target organ of TiNPs. We recently reported that TiNPs had no genotoxic effect in the liver and bone marrow, while showing clear testicular dysfunction. In this paper, therefore, we systematically compared the sensitivity of hepatic function using biochemical markers and testicular function against TiNPs. Male C57BL/6J mice were injected intravenously with TiNPs (Aeroxide-P25, at doses of 0.1, 1, 2, and 10 mg/kg body weight) once per week for 4 consecutive weeks. Mice were sacrificed three days after the last injection. Body weights, liver weights, and testicular-related organ weights were not found to be changed by TiNP treatment. Moreover, TiNPs caused no hepatic damage, as evaluated by alanine aminotransferase and aspartate aminotransferase indexes. The testicular function, however, was clearly impaired by TiNP treatment; reduction in two sperm motion parameters (motile percent and progressive percent) and sperm numbers in cauda epididymides was seen. We observed Ti accumulation in the liver but not in the testis, as well as no change in plasma levels of sex hormones related to spermatogenesis. Our findings indicate that the testis is highly sensitive to TiNPs, as compared to the liver. We believe that, when considering the biological effects of TiNPs, testicular function (especially motility ability) may be a sensitive indicator.
[Mh] Termos MeSH primário: Nanopartículas Metálicas/toxicidade
Doenças Testiculares/induzido quimicamente
Testículo/efeitos dos fármacos
Titânio/toxicidade
[Mh] Termos MeSH secundário: Animais
Doença Hepática Induzida por Substâncias e Drogas/etiologia
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Camundongos Endogâmicos C57BL
Contagem de Espermatozoides
Motilidade Espermática/efeitos dos fármacos
Espermatogênese/efeitos dos fármacos
Testículo/metabolismo
Titânio/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
D1JT611TNE (Titanium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170513
[St] Status:MEDLINE
[do] DOI:10.2131/jts.42.359


  7 / 4027 MEDLINE  
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[PMID]:28401283
[Au] Autor:Mathur M; Mills I; Spektor M
[Ad] Endereço:Department of Radiology and Biomedical Imaging, Yale School of Medicine, 333 Cedar Street, Room TE-2, PO Box 208042, New Haven, CT, 06520, USA. mahan.mathur@yale.edu.
[Ti] Título:Magnetic resonance imaging of the scrotum: pictorial review with ultrasound correlation.
[So] Source:Abdom Radiol (NY);42(7):1929-1955, 2017 Jul.
[Is] ISSN:2366-0058
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The purpose of this review is to showcase the added value of scrotal magnetic resonance imaging (MRI) in the workup of neoplastic and non-neoplastic entities. While ultrasound (US) remains the first-line imaging modality for evaluating scrotal pathology, MRI may add valuable information, particularly when US findings are equivocal. The inherent soft tissue resolution characteristics of MRI, as well as the ability to detect subtle enhancement and provide wider field-of-view imaging, can prove useful in evaluating inconclusive US findings. The added value of MR in these instances is critical as it may have a significant impact on patient management.
[Mh] Termos MeSH primário: Imagem por Ressonância Magnética/métodos
Escroto/diagnóstico por imagem
Doenças Testiculares/diagnóstico por imagem
Ultrassonografia/métodos
[Mh] Termos MeSH secundário: Seres Humanos
Aumento da Imagem/métodos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170413
[St] Status:MEDLINE
[do] DOI:10.1007/s00261-017-1127-2


  8 / 4027 MEDLINE  
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[PMID]:28267895
[Au] Autor:Pedersen MR; Møller H; Rafaelsen SR; Jørgensen MM; Osther PJ; Vedsted P
[Ad] Endereço:Department of Radiology, Vejle Hospital, Part of Lillebaelt Hospital, Vejle, Denmark.
[Ti] Título:Characteristics of symptomatic men with testicular microlithiasis - A Danish cross-sectional questionnaire study.
[So] Source:Andrology;5(3):556-561, 2017 May.
[Is] ISSN:2047-2927
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Testicular microlithiasis (TML) is an incidental finding at ultrasonography of the scrotum. A link between testicular microlithiasis and testicular cancer has been suggested. However, the majority of studies are retrospective using ultrasonography with minor data on health status and life style characteristics. Our objective was to investigate if lifestyle and health are associated with TML. In 2014, we conducted a self-administered questionnaire survey including 1538 men, who all due to testicular/scrotal symptoms had an ultrasound investigation of the scrotum during 2004-2013. The men were divided into men with TML and men without. The 23-items questionnaire included items on age, height, weight, lifestyle (alcohol consumptions, smoking habits, workload, exercise and food), previous diseases in the testicles, pain and consumption of analgesics. The prevalence of TML was 12.8%. Overall, lifestyle factors did not vary between men with or without TML. However, men with TML did consume more crisp than men without. Development of TML was not associated to classic life style factors such as alcohol consumption, smoking habits, or mothers smoking during pregnancy. Also, age and height could not be linked to presence of TML. We did find, however, that men with TML experienced less physical activity and consumed more crisp than men without TML. Since ingestion of crisps has potential carcinogenic effect (acrylamide), this finding needs confirmation in a separate study.
[Mh] Termos MeSH primário: Cálculos/epidemiologia
Doenças Testiculares/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Estudos Transversais
Dinamarca/epidemiologia
Seres Humanos
Masculino
Meia-Idade
Prevalência
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE
[do] DOI:10.1111/andr.12326


  9 / 4027 MEDLINE  
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[PMID]:28263137
[Au] Autor:Pridjian AA; Sharbaugh A; Raval A; McGinnis D
[Ad] Endereço:Department of Urology, Sidney Kimmel Medical College - Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
[Ti] Título:Paratesticular fibrous pseudotumor.
[So] Source:Can J Urol;24(1):8676-8678, 2017 Feb.
[Is] ISSN:1195-9479
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:We present a rare case of fibrous pseudotumor of the tunica vaginalis. Discussion includes identification, histopathologic findings and management. Proper understanding and preoperative identification of this benign disease allows for an organ-sparing surgical approach.
[Mh] Termos MeSH primário: Granuloma de Células Plasmáticas/diagnóstico por imagem
Granuloma de Células Plasmáticas/patologia
Doenças Testiculares/diagnóstico por imagem
Doenças Testiculares/patologia
[Mh] Termos MeSH secundário: Idoso
Epididimo
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Ultrassonografia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE


  10 / 4027 MEDLINE  
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[PMID]:28249332
[Au] Autor:Tadeu Spadella C; Teixeira Trindade AA; Natália Lucchesi A; Sperandéo de Macedo C
[Ad] Endereço:Surgery and Orthopedics, Botucatu School of Medicine - UNESP, Botucatu, Brazil.
[Ti] Título:Pancreas Transplantation Delays the Progression of Morphological, Morphometric and Ultrastructural Changes in Testes of Alloxan-Induced Diabetic Rats.
[So] Source:Exp Clin Endocrinol Diabetes;125(2):106-115, 2017 Feb.
[Is] ISSN:1439-3646
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to assess the effects of pancreas transplantation on the progression of testicular lesions in diabetic rats. Diabetic rats were subjected to pancreas transplantation and sacrificed after 6, 14, 26 and 50 weeks of follow-up, using non-diabetic and untreated diabetic rats as controls. Successful pancreas transplantation corrected all of the metabolic changes observed in diabetic rats, including low levels of testosterone. The testicular mass was decreased, and the relative weight of the testes was high in diabetic rats. The seminiferous tubules of diabetic rats showed progressive atrophy of the germinal epithelium, with cytoplasmic vacuolization, detachment of germ cells to the tubular lumen and the appearance of giant cells. Leydig cells were abnormally distributed, and hyperplasia of Sertoli cells was observed. Sperm were not detectable within the tubular lumen in late follow-up. The diameter, total area, lumen area, and germinal epithelium area of the seminiferous tubules were low, and tubular density was high in diabetic rats. Ultrastructural changes were also observed in these rats, compromising the cytoplasm, organelles and cellular nuclei of the germ, Sertoli, and Leydig cells. The most frequent changes consisted of accumulation of lipid droplets and electron-dense dark material in the cell cytoplasm, cellular degeneration and apoptosis. Similar to non-diabetic rats, pancreas-transplanted rats showed progressive testicular lesions, but they were much less severe and occurred much later than in the untreated diabetic controls. Diabetes causes morphological and ultrastructural changes in rat testes, but the progression of lesions can be significantly delayed by successful pancreas transplantation, which may have a positive impact on male infertility due to diabetes.
[Mh] Termos MeSH primário: Complicações do Diabetes
Diabetes Mellitus Experimental
Transplante de Pâncreas
Doenças Testiculares
Testículo
[Mh] Termos MeSH secundário: Animais
Complicações do Diabetes/metabolismo
Complicações do Diabetes/patologia
Complicações do Diabetes/cirurgia
Diabetes Mellitus Experimental/metabolismo
Diabetes Mellitus Experimental/patologia
Diabetes Mellitus Experimental/cirurgia
Masculino
Ratos
Ratos Endogâmicos Lew
Espermatogênese
Doenças Testiculares/etiologia
Doenças Testiculares/metabolismo
Doenças Testiculares/patologia
Doenças Testiculares/cirurgia
Testículo/metabolismo
Testículo/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170317
[Lr] Data última revisão:
170317
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE
[do] DOI:10.1055/s-0042-122137



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