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[PMID]:28759642
[Au] Autor:Vitale ML; Garcia CJ; Akpovi CD; Pelletier RM
[Ad] Endereço:Département de pathologie et biologie cellulaire, Faculté de Médecine, Université de Montréal, Montreal, Québec, Canada.
[Ti] Título:Distinctive actions of connexin 46 and connexin 50 in anterior pituitary folliculostellate cells.
[So] Source:PLoS One;12(7):e0182495, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Folliculostellate cell gap junctions establish a network for the transmission of information within the anterior pituitary. Connexins make up gap junction channels. Changes in connexin (Cx) turnover modify gap junction-mediated intercellular communication. We have reported that cytokines and hormones influence Cx43 turnover and coupling in folliculostellate cells and in the folliculostellate cell line TtT/GF. In addition, the expression of different connexins alters intercellular communication and connexins may have functions besides cell coupling. Here we assessed the expression, turnover and subcellular localization of Cx46 and Cx50 in the anterior pituitary and TtT/GF cells. Then, we assessed the impact of various natural (lactation, annual reproductive cycle, bFGF) and pathological (autoimmune orchitis, diabetes/obesity) conditions associated with altered anterior pituitary hormone secretion on Cx46 and Cx50. Anterior pituitary Cx46 and Cx50 expression and subcellular distribution were cell-dependent. Cx46 was expressed by folliculostellate, TtT/GF and endocrine cells. In the cytoplasm, Cx46 was chiefly associated with lysosomes. Variously sized Cx46 molecules were recovered exclusively in the TtT/GF cell nuclear fraction. In the nucleus, Cx46 co-localized with Nopp-140, a nucleolar factor involved in rRNA processing. Neither cytoplasmic nor nuclear Cx46 and Cx43 co-localized. Cx50 localized to folliculostellate and TtT/GF cells, and to the walls of blood capillaries, not to endocrine cells. Cx50 was cytoplasmic and associated with the cell membrane, not nuclear. Cx50 did not co-localize with Cx46 but it co-localized in the cytoplasm and co-immunoprecipitated with Cx43. Cx46 and Cx50 responses to various physiological and pathological challenges were different, often opposite. Cx46 and Cx43 expression and phosphorylation profiles differed in the anterior pituitary, whereas Cx50 and Cx43 were similar. The data suggest that Cx46 participates to cellular growth and proliferation and that Cx50, together with Cx43, contributes to folliculostellate cell coupling.
[Mh] Termos MeSH primário: Conexinas/metabolismo
Adeno-Hipófise/metabolismo
[Mh] Termos MeSH secundário: Animais
Membrana Celular/metabolismo
Núcleo Celular/metabolismo
Células Cultivadas
Conexinas/genética
Diabetes Mellitus/metabolismo
Células Endócrinas/metabolismo
Células Epiteliais/metabolismo
Feminino
Lactação/metabolismo
Lisossomos/metabolismo
Masculino
Camundongos
Vison
Obesidade/metabolismo
Orquite/metabolismo
Adeno-Hipófise/citologia
Hormônios Adeno-Hipofisários/secreção
Reprodução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Connexins); 0 (Pituitary Hormones, Anterior); 0 (connexin 46); 0 (connexin 50)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182495


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[PMID]:28407803
[Au] Autor:Tampakis A; Tampaki EC; Damaskos C; Feretis T; Thymara I; Kontzoglou K; Tomos P; Kouraklis G
[Ad] Endereço:Department of Visceral Surgery, University Hospital of Basel, Spitalstrasse 21, 4056, Basel, Switzerland. athantamp@hotmail.com.
[Ti] Título:Orchitis reveals an extragonadal primary mediastinal thymic seminoma: a coincidence or not?
[So] Source:World J Surg Oncol;15(1):85, 2017 Apr 13.
[Is] ISSN:1477-7819
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Mediastinal thymic seminomas are rare male germ cell tumors with extragonadal origin that appear predominately with a cystic appearance. CASE PRESENTATION: A 22-year-old male was referred to our department for further investigation of a mediastinal mass discovered incidentally during routine chest X-ray. The patient has denied any symptoms including dyspnea, chest pain, cough, fever, dysphagia, hemoptysis, weight loss, and weakness. His past medical history was remarkable for orchitis, for which he had undergone a bilateral testicular biopsy, without the latter however, indicating the presence of a germ cell tumor or a premalignant lesion. Contrast-enhanced chest computed tomography revealed a lobulated and well-marginated cystic lesion in the anterior mediastinum. Differential diagnosis included mostly a multilocular thymic cyst, a lymphoma, a seminoma, or a soft tissue tumor. Resection of the mass revealed a primary thymic seminoma. CONCLUSIONS: A surgical approach for the management of these tumors might be reasonable considering that an extensive sampling is mandatory to gain an appropriate biopsy preoperatively in order to securely confirm or refute the presence of a mediastinal extragonadal tumor. Orchitis might be a sign of a general disorder of the germ cells which might transform in time.
[Mh] Termos MeSH primário: Neoplasias do Mediastino/diagnóstico
Orquite/patologia
Seminoma/diagnóstico
Neoplasias do Timo/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Diagnóstico Diferencial
Seres Humanos
Masculino
Neoplasias do Mediastino/cirurgia
Orquite/cirurgia
Prognóstico
Seminoma/cirurgia
Neoplasias do Timo/cirurgia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE
[do] DOI:10.1186/s12957-017-1146-z


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[PMID]:27890874
[Au] Autor:Noguchi J; Watanabe S; Nguyen TQ; Kikuchi K; Kaneko H
[Ad] Endereço:Institute of Agrobiological Sciences, National Agriculture and Food Research Organization (NARO), Ibaraki 305-8602, Japan.
[Ti] Título:Development of a lipopolysaccharide (LPS)-supplemented adjuvant and its effects on cell-mediated and humoral immune responses in male rats immunized against sperm.
[So] Source:J Reprod Dev;63(1):111-115, 2017 Feb 16.
[Is] ISSN:1348-4400
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Supplementation with lipopolysaccharide (LPS) from non-pathogenic Escherichia coli was found to enhance the adjuvant effects of a veterinary vaccine adjuvant (ISA 71VG ). Sperm immunization using 71VG as an adjuvant in the immature period induced infertility in 25% of male rats, whereas this increased to 62.5% after immunization with 71VG + LPS or Freund's complete adjuvant (FCA). Mean testicular weight of non-sterile males in the 71VG + LPS group was significantly lower than that in the 71VG or FCA group. Histological examination of testicular tissue from sterile males demonstrated severe impairment of spermatogenesis due to experimental autoimmune orchitis, a cell-mediated autoimmune condition. The serum anti-sperm titer was elevated in the three sperm-immunized groups relative to male rats treated with adjuvant alone, but the titer was higher in the 71VG + LPS and FCA groups than in the 71VG group. We consider that this LPS-supplemented adjuvant stimulates both humoral and cell-mediated immune responses to an extent comparable to FCA.
[Mh] Termos MeSH primário: Adjuvantes Imunológicos
Imunidade Celular
Imunidade Humoral
Lipopolissacarídeos/química
Orquite/tratamento farmacológico
Espermatozoides/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Anticorpos/química
Doenças Autoimunes/imunologia
Epididimo/metabolismo
Feminino
Adjuvante de Freund
Imunidade Humoral/imunologia
Imunização
Imunoglobulina G/química
Masculino
Orquite/imunologia
Ratos
Ratos Wistar
Espermatogênese/efeitos dos fármacos
Espermatozoides/imunologia
Testículo/efeitos dos fármacos
Testículo/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adjuvants, Immunologic); 0 (Antibodies); 0 (Immunoglobulin G); 0 (Lipopolysaccharides); 9007-81-2 (Freund's Adjuvant)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161129
[St] Status:MEDLINE
[do] DOI:10.1262/jrd.2016-144


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[PMID]:27246506
[Au] Autor:Eskandari M; Ghalyanchi Langeroudi A; Zeighami H; Rostami A; Kazemi M; Eyni H; Shokri S
[Ad] Endereço:Department of Physiology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
[Ti] Título:Co-administration of ginseng and ciprofloxacin ameliorates epididymo-orchitis induced alterations in sperm quality and spermatogenic cells apoptosis following infection in rats.
[So] Source:Andrologia;49(3), 2017 Apr.
[Is] ISSN:1439-0272
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Korean red ginseng (KRG) may be a beneficial adjuvant along with ciprofloxacin to ameliorate devastating effects of epididymo-orchitis (EO) on male fertility. This study intends to assay the effects of KRG and ciprofloxacin on sperm quality and spermatogenic cells apoptosis in EO rats. We divided 54 adult rats into nine groups (n = 6 rats per group): control (CO), sham-operated (SH), EO (E); ciprofloxacin (C), EO-ciprofloxacin (EC), KRG (G), EO-KRG (EG), ciprofloxacin-KRG (CG) and EO-ciprofloxacin-KRG (ECG). We administered ciprofloxacin and KRG 48 hr after the Escherichia coli (E. coli) injection for 10 days. Bilateral orchiectomy was performed after one sperm cycle (14 days) following the last treatment with ciprofloxacin and KRG. Total and progressive motility of E, C and EC groups decreased. However, motility is improved in CG and ECG in comparison with these groups. The E group induced negative changes in the architecture of testes tissue and dramatic increase in apoptosis indices. Interestingly, co-administration of ciprofloxacin and KRG has dramatically improved Miller's and Johnsen's scores and decreased the apoptosis indices of animals in the ECG group. Combined treatment of ciprofloxacin and KRG may improve the quality of spermatozoa and attenuated apoptosis indices in the ECG group.
[Mh] Termos MeSH primário: Antibacterianos/efeitos adversos
Ciprofloxacino/efeitos adversos
Epididimite/tratamento farmacológico
Orquite/tratamento farmacológico
Panax/química
Extratos Vegetais/uso terapêutico
Motilidade Espermática/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antibacterianos/uso terapêutico
Apoptose/efeitos dos fármacos
Ciprofloxacino/uso terapêutico
Modelos Animais de Doenças
Epididimite/complicações
Epididimite/microbiologia
Escherichia coli/isolamento & purificação
Infecções por Escherichia coli/complicações
Infecções por Escherichia coli/tratamento farmacológico
Infecções por Escherichia coli/microbiologia
Seres Humanos
Masculino
Orquite/complicações
Orquite/microbiologia
Ratos
Ratos Wistar
Espermatozoides/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Plant Extracts); 5E8K9I0O4U (Ciprofloxacin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170505
[Lr] Data última revisão:
170505
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160602
[St] Status:MEDLINE
[do] DOI:10.1111/and.12621


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[PMID]:27222288
[Au] Autor:Cherif S; Yoganathan K; Banks T; Abdulla R
[Ad] Endereço:1 Department of Genitourinary and HIV Medicine, Singleton Hospital, Swansea, UK.
[Ti] Título:Unmasking immune reconstitution inflammatory syndrome: a report of tuberculous epididymo-orchitis mimicking a testicular tumour in a Caucasian AIDS patient.
[So] Source:Int J STD AIDS;28(1):100-103, 2017 Jan.
[Is] ISSN:1758-1052
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Worldwide, it is estimated that 14.8% of all new tuberculosis cases in adults are attributable to HIV infection. Genitourinary tuberculosis is a known complication and is considered to be a severe form of extrapulmonary tuberculosis. Isolated tuberculous epididymo-orchitis is rare. We report a Caucasian HIV-positive heterosexual male with a clinical diagnosis of testicular tumour for which he underwent a right orchidectomy. Tuberculous epididymo-orchitis was confirmed by histology. In this case, all Immune Reconstitution Inflammatory Syndrome (IRIS) criteria were met. We want to convey the message that in HIV-positive patients presenting with testicular swelling, an infective aetiology should be considered. This will increase the possibility of early diagnosis and proper management.
[Mh] Termos MeSH primário: Síndrome de Imunodeficiência Adquirida/complicações
Epididimite/complicações
Infecções por HIV/complicações
Síndrome Inflamatória da Reconstituição Imune/complicações
Tuberculose dos Genitais Masculinos/complicações
[Mh] Termos MeSH secundário: Terapia Antirretroviral de Alta Atividade
Diagnóstico Diferencial
Infecções por HIV/tratamento farmacológico
Heterossexualidade
Seres Humanos
Masculino
Meia-Idade
Orquiectomia
Orquite/diagnóstico
Neoplasias Testiculares/complicações
Neoplasias Testiculares/cirurgia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM; X
[Da] Data de entrada para processamento:160526
[St] Status:MEDLINE
[do] DOI:10.1177/0956462416652536


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[PMID]:27884655
[Au] Autor:Chan JF; Zhang AJ; Chan CC; Yip CC; Mak WW; Zhu H; Poon VK; Tee KM; Zhu Z; Cai JP; Tsang JO; Chik KK; Yin F; Chan KH; Kok KH; Jin DY; Au-Yeung RK; Yuen KY
[Ad] Endereço:State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region, China; Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, China; Research Centre of Infection and Immunology, The University of H
[Ti] Título:Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons.
[So] Source:EBioMedicine;14:112-122, 2016 Dec.
[Is] ISSN:2352-3964
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Disseminated or fatal Zika virus (ZIKV) infections were reported in immunosuppressed patients. Existing interferon-signaling/receptor-deficient mouse models may not be suitable for evaluating treatment effects of recombinant interferons. METHODS: We developed a novel mouse model for ZIKV infection by immunosuppressing BALB/c mice with dexamethasone. RESULTS: Dexamethasone-immunosuppressed male mice (6-8weeks) developed disseminated infection as evidenced by the detection of ZIKV-NS1 protein expression and high viral loads in multiple organs. They had ≥10% weight loss and high clinical scores soon after dexamethasone withdrawal (10dpi), which warranted euthanasia at 12dpi. Viral loads in blood and most tissues at 5dpi were significantly higher than those at 12dpi (P<0.05). Histological examination revealed prominent inflammatory infiltrates in multiple organs, and CD45+ and CD8+ inflammatory cells were seen in the testis. These findings suggested that clinical deterioration occurred during viral clearance by host immune response. Type I interferon treatments improved clinical outcome of mice (100% vs 0% survival). CONCLUSIONS: Besides virus dissemination, inflammation of various tissues, especially orchitis, may be potential complications of ZIKV infection with significant implications on disease transmission and male fertility. Interferon treatment should be considered in patients at high risks for ZIKV-associated complications when the potential benefits outweigh the side effects of treatment.
[Mh] Termos MeSH primário: Antivirais/farmacologia
Hospedeiro Imunocomprometido
Interferon Tipo I/farmacologia
Orquite/virologia
Infecção pelo Zika virus/imunologia
Infecção pelo Zika virus/virologia
Zika virus/efeitos dos fármacos
Zika virus/imunologia
[Mh] Termos MeSH secundário: Animais
Encéfalo/imunologia
Encéfalo/metabolismo
Encéfalo/patologia
Dexametasona/efeitos adversos
Modelos Animais de Doenças
Feminino
Rim/imunologia
Rim/metabolismo
Rim/patologia
Masculino
Camundongos
Orquite/tratamento farmacológico
Carga Viral
Infecção pelo Zika virus/tratamento farmacológico
Infecção pelo Zika virus/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Interferon Type I); 7S5I7G3JQL (Dexamethasone)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161126
[St] Status:MEDLINE


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[PMID]:27585828
[Au] Autor:Roe C; May LS
[Ad] Endereço:Brighton and Sussex Medical School, Brighton, UK. c.roe@doctors.org.uk.
[Ti] Título:A case of leprosy in Malawi. Making the final push towards eradication: a clinical and public health perspective.
[So] Source:Infect Dis Poverty;5(1):90, 2016 Sep 02.
[Is] ISSN:2049-9957
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Statistically speaking, Malawi has achieved the World Health Organisation's target for the elimination of leprosy (<1 case per 10 000 people), yet the disease is still considered a leading cause of long term physical disability. In this case study the authors discuss the presentation of a 39-year-old gentleman to a district hospital in Malawi with multibacillary, lepromatous leprosy. The condition was initially managed in the community as an 'allergy' which suggests that local barriers currently hinder the detection of leprosy in this developing primary care system. Leprosy is a multi-system disease and this gentleman demonstrated evidence of lepromatous orchitis. Promoting an awareness of these systemic manifestations will increase the the detection of complications and circumvent long term morbidity. Efforts to optimise systems of detection, management and public and professional education are essential to drive eradication in these at-risk populations. At an international level, we must strive to fulfil the objectives outlined by the 'Enhanced Global Strategy for Further Reducing the Disease Burden due to Leprosy for 2011-2015'. At a national level, local research should delineate community factors that impede the eradication of leprosy. Developing new diagnostic and epidemiologic tools, more efficacious chemoprophylactic regimens and vaccination for endemic regions would facilitate these efforts.
[Mh] Termos MeSH primário: Conhecimentos, Atitudes e Prática em Saúde
Hanseníase Virchowiana/diagnóstico
Hanseníase Virchowiana/prevenção & controle
Mycobacterium leprae/fisiologia
Orquite/diagnóstico
Saúde Pública
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Hanseníase Virchowiana/complicações
Hanseníase Virchowiana/psicologia
Malaui
Masculino
Orquite/tratamento farmacológico
Orquite/microbiologia
Orquite/prevenção & controle
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160903
[St] Status:MEDLINE
[do] DOI:10.1186/s40249-016-0176-z


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[PMID]:27562958
[Au] Autor:Yung CF; Ramsay M
[Ad] Endereço:Infectious Disease Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore.
[Ti] Título:Estimating true hospital morbidity of complications associated with mumps outbreak, England, 2004/05.
[So] Source:Euro Surveill;21(33), 2016 Aug 18.
[Is] ISSN:1560-7917
[Cp] País de publicação:Sweden
[La] Idioma:eng
[Ab] Resumo:Mumps outbreaks in highly vaccinated populations continue to be reported globally. Therefore, quantifying the burden of mumps morbidity accurately will be necessary to better assess the impact of mumps vaccination programmes. We aim to estimate the true morbidity resulting from mumps complications in terms of hospitalised orchitis, meningitis, oophoritis and pancreatitis in England during the outbreak in 2004/05. This outbreak in England led to a clear increase in hospitalisations coded to mumps for complications of orchitis in those born in the 1970s and 1980s and possibly for meningitis in those born in the 1980s. A simple statistical model, based on analysing time trends for diagnosed complications in hospital databases with routine laboratory surveillance data, found that the actual morbidity was much higher. There were 2.5 times (166 cases) more mumps orchitis cases in the 1970s cohort and 2.0 times (708 cases) more mumps orchitis cases in the 1980s cohort than complications coded to mumps in hospital databases. Our study demonstrated that the mumps outbreak in England 2004/05 resulted in a substantial increase in hospitalised mumps complications, and the model we used can improve the ascertainment of morbidity from a mumps outbreak.
[Mh] Termos MeSH primário: Surtos de Doenças
Hospitalização/estatística & dados numéricos
Caxumba/epidemiologia
[Mh] Termos MeSH secundário: Inglaterra/epidemiologia
Feminino
Seres Humanos
Masculino
Meningite Viral/epidemiologia
Meningite Viral/etiologia
Morbidade
Caxumba/complicações
Ooforite/epidemiologia
Ooforite/etiologia
Orquite/epidemiologia
Orquite/etiologia
Pancreatite/epidemiologia
Pancreatite/etiologia
Vigilância da População
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160827
[St] Status:MEDLINE
[do] DOI:10.2807/1560-7917.ES.2016.21.33.30320


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[PMID]:27556195
[Au] Autor:Chang CD; Lin JW; Lee CC; Chen YT; Huang CC; Lee YW; Ng SH; Ko SF
[Ad] Endereço:*Departments of Radiology and †Pathology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine; ‡Department of Biomedical Engineering, I-Shou University; and §Division of Urology, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, Republic of China.
[Ti] Título:Acute Epididymo-orchitis-Related Global Testicular Infarction: Clinical and Ultrasound Findings With an Emphasis on the Juxta-epididymal String-of-Bead Sign.
[So] Source:Ultrasound Q;32(3):283-9, 2016 Sep.
[Is] ISSN:1536-0253
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Acute epididymo-orchitis (AEO)-related global testicular infarction (GTI) is rare. We report herein the clinical and ultrasound findings of 6 patients with AEO-related GTI. Seventeen patients with torsion-related GTI were also reviewed and compared. The echotexture of AEO-related GTI ranged from mildly inhomogeneous to diffuse heteroechoic, depending on the severity of testicular necrotic changes. All of the patients showed a juxta-epididymal string-of-bead pattern on color Doppler ultrasound, which was ascribed to patent arteries (5/6, 87%) and collateral vessels (1/6, 13%) in the tunica albuginea. There were no significant differences in age, laterality, leukocyte count, testicular volume ratio (infarcted/normal), frequencies of heteroechoic testicular parenchyma, scrotal skin thickening, and hydrocele between the 2 groups. However, the left testis was predominantly affected in both groups. Compared with torsion-related GTI, patients with AEO-related GTI had significantly longer duration from scrotal pain onset to surgery (13.5 ± 5.2 vs 2.6 ± 2.0 days, P < 0.001), a higher level of serum C-reactive protein (110.0 ± 82.0 vs 41.2 ± 35.9 mg/dL, P = 0.013), a higher frequency of the juxta-epididymal string-of-bead sign (100% vs 12%, P < 0.001), and a lower frequency of the whirlpool/knot sign (0% vs 88%, P = 0.002). Although the testis in AEO-related GTI may appear variable from mildly to extensively heteroechoic on gray-scale ultrasound, this unusual disease can be characterized by an avascular testis with a juxta-epididymal string-of-bead sign on color Doppler ultrasound.
[Mh] Termos MeSH primário: Epididimite/diagnóstico por imagem
Infarto/diagnóstico por imagem
Orquite/diagnóstico por imagem
Testículo/irrigação sanguínea
Testículo/diagnóstico por imagem
[Mh] Termos MeSH secundário: Doença Aguda
Adulto
Idoso
Criança
Epididimo/diagnóstico por imagem
Epididimite/complicações
Seres Humanos
Infarto/complicações
Masculino
Meia-Idade
Orquite/complicações
Estudos Retrospectivos
Índice de Gravidade de Doença
Ultrassonografia
Ultrassonografia Doppler em Cores
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170503
[Lr] Data última revisão:
170503
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160825
[St] Status:MEDLINE
[do] DOI:10.1097/RUQ.0000000000000225


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[PMID]:27472731
[Au] Autor:Yen CH; Liu CY; Cha TL; Wu ST; Meng E; Sun GH; Yu DS; Chen HI; Chang SY; Tsao CW
[Ad] Endereço:aDivision of Urology, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center bDivision of Urology, Department of Surgery, Tri-Service General Hospital, Song-Shan Branch, Taipei cDepartment of Nutritional Science, Fu Jen Catholic University, New Taipei City dGraduate Institute of Medical Sciences, Chang Jung Christian University, Tainan, Taiwan.
[Ti] Título:Emphysematous epididymo-orchitis as a camouflage of prostate invasion secondary to rectum cancer: A case report.
[So] Source:Medicine (Baltimore);95(30):e4385, 2016 Jul.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Emphysematous epididymo-orchitis is a rare cause of acute scrotum pain characterized by gas formation within the tissue. Diabetes mellitus and recto-seminal fistula secondary to sigmoid diverticulitis are generally accepted as being responsible for this disease. However, prostate invasion secondary to rectal cancer may be considered to be a newly identified pathogenetic mechanism. Herein, we report this rare case and illustrate the pathogenesis. CASE PRESENTATION: A 69-year-old man arrived at our emergency department presenting with sepsis and acute scrotal pain. Emphysematous epididymo-orchitis was diagnosed by scrotal sonography initially; however, advanced rectal cancer with prostate invasion was diagnosed by CT after a recurrent episode. An exploratory laparotomy with abdominoperineal resection and radical prostectomy were performed after neoadjuvant chemoradiotherapy. Histopathologic analysis confirmed the previous diagnosis. Emphysematous epididymo-orchitis caused by advanced rectal cancer is very rare, and our case is the first to be reported according to a literature search. Neoadjuvant chemoradiotherapy plus extended surgery can achieve a good oncological outcome. CONCLUSION: This case indicated that the very rare presentation as emphysematous epididymo-orchitis caused by locally advanced colorectal cancer.
[Mh] Termos MeSH primário: Adenocarcinoma/diagnóstico
Adenocarcinoma/secundário
Neoplasias Colorretais/diagnóstico
Enfisema/diagnóstico
Epididimite/diagnóstico
Orquite/diagnóstico
Neoplasias da Próstata/diagnóstico
Neoplasias da Próstata/secundário
[Mh] Termos MeSH secundário: Dor Aguda/etiologia
Adenocarcinoma/patologia
Adenocarcinoma/cirurgia
Idoso
Neoplasias Colorretais/patologia
Neoplasias Colorretais/cirurgia
Erros de Diagnóstico
Enfisema/patologia
Enfisema/cirurgia
Epididimite/patologia
Epididimite/cirurgia
Seres Humanos
Masculino
Estadiamento de Neoplasias
Orquite/patologia
Orquite/cirurgia
Próstata/patologia
Neoplasias da Próstata/patologia
Neoplasias da Próstata/cirurgia
Reto/patologia
Recidiva
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160730
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000004385



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