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[PMID]:28739328
[Au] Autor:Marques S; Santos S; Fremin K; Fogo AB
[Ad] Endereço:Department of Nephrology, Centro Hospitalar São João, Porto, Portugal; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN. Electronic address: sofiahomemdemelo@gmail.com.
[Ti] Título:A Case of Oxalate Nephropathy: When a Single Cause Is Not Crystal Clear.
[So] Source:Am J Kidney Dis;70(5):722-724, 2017 Nov.
[Is] ISSN:1523-6838
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hyperoxaluria can result in oxalate nephropathy with intratubular calcium oxalate crystallization and acute tubular injury. Primary inherited enzymatic deficiency or secondary causes such as excessive dietary intake, enteric increased absorption, or high doses of vitamin C, which is metabolized to oxalate, may underlie hyperoxaluria and oxalate nephropathy. We report a case of acute kidney injury due to oxalate nephropathy in a patient using chelating therapy with oral ethylenediamine tetra acetic acid (EDTA), intravenous supplementation with vitamin C, and chronic diarrhea and discuss the potential kidney damage these factors can cause in particular settings. To our knowledge, this is the first report suggesting an association between oral EDTA and oxalate nephropathy.
[Mh] Termos MeSH primário: Lesão Renal Aguda/etiologia
Ácido Ascórbico/efeitos adversos
Quelantes de Cálcio/efeitos adversos
Oxalato de Cálcio
Diarreia/complicações
Ácido Edético/efeitos adversos
Hiperoxalúria/etiologia
Vitaminas/efeitos adversos
[Mh] Termos MeSH secundário: Lesão Renal Aguda/patologia
Lesão Renal Aguda/terapia
Idoso
Seres Humanos
Necrose Tubular Aguda/etiologia
Necrose Tubular Aguda/patologia
Masculino
Diálise Renal
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calcium Chelating Agents); 0 (Vitamins); 2612HC57YE (Calcium Oxalate); 9G34HU7RV0 (Edetic Acid); PQ6CK8PD0R (Ascorbic Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE


  2 / 802 MEDLINE  
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[PMID]:28602796
[Au] Autor:Lieske JC
[Ad] Endereço:Mayo Clinic Division of Nephrology and Hypertension, Rochester, Minnesota.
[Ti] Título:Is the intestinal microbiome a modifiable cofactor in the development of hyperoxaluria after Roux-en-Y gastric bypass?
[So] Source:Surg Obes Relat Dis;13(7):1157-1158, 2017 07.
[Is] ISSN:1878-7533
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Derivação Gástrica
Obesidade Mórbida/cirurgia
[Mh] Termos MeSH secundário: Anastomose em-Y de Roux
Microbioma Gastrointestinal
Seres Humanos
Hiperoxalúria/cirurgia
Obesidade/cirurgia
[Pt] Tipo de publicação:EDITORIAL; COMMENT
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE


  3 / 802 MEDLINE  
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[PMID]:28489752
[Au] Autor:Demoulin N; Issa Z; Crott R; Morelle J; Danse E; Wallemacq P; Jadoul M; Deprez PH
[Ad] Endereço:aDivision of Nephrology, Cliniques universitaires Saint-Luc bInstitut de Recherche Expérimentale et Clinique cInstitut de Recherche Santé et Société, Université catholique de Louvain dDepartment of Radiology eDepartment of Clinical Chemistry fDepartment of Hepato-Gastroenterology, Cliniques universitaires Saint-Luc, Brussels, Belgium.
[Ti] Título:Enteric hyperoxaluria in chronic pancreatitis.
[So] Source:Medicine (Baltimore);96(19):e6758, 2017 May.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chronic pancreatitis may lead to steatorrhea, enteric hyperoxaluria, and kidney damage. However, the prevalence and determinants of hyperoxaluria in chronic pancreatitis patients as well as its association with renal function decline have not been investigated.We performed an observational study. Urine oxalate to creatinine ratio was assessed on 2 independent random urine samples in consecutive adult patients with chronic pancreatitis followed at the outpatient clinic from March 1 to October 31, 2012. Baseline characteristics and annual estimated glomerular filtration rate (eGFR) change during follow-up were compared between patients with hyper- and normo-oxaluria.A total of 48 patients with chronic pancreatitis were included. The etiology of the disease was toxic (52%), idiopathic (27%), obstructive (11%), autoimmune (6%), or genetic (4%). Hyperoxaluria (defined as urine oxalate to creatinine ratio >32 mg/g) was found in 23% of patients. Multivariate regression analysis identified clinical steatorrhea, high fecal acid steatocrit, and pancreatic atrophy as independent predictors of hyperoxaluria. Taken together, a combination of clinical steatorrhea, steatocrit level >31%, and pancreatic atrophy was associated with a positive predictive value of 100% for hyperoxaluria. On the contrary, none of the patients with a fecal elastase-1 level >100 µg/g had hyperoxaluria. Longitudinal evolution of eGFR was available in 71% of the patients, with a mean follow-up of 904 days. After adjustment for established determinants of renal function decline (gender, diabetes, bicarbonate level, baseline eGFR, and proteinuria), a urine oxalate to creatinine ratio >32 mg/g was associated with a higher risk of eGFR decline.Hyperoxaluria is highly prevalent in patients with chronic pancreatitis and associated with faster decline in renal function. A high urine oxalate to creatinine ratio in patients with chronic pancreatitis is best predicted by clinical steatorrhea, a high acid steatocrit, and pancreatic atrophy. Further studies will need to investigate the mechanisms of renal damage in chronic pancreatitis and the potential benefits of therapies reducing oxaluria.
[Mh] Termos MeSH primário: Hiperoxalúria/etiologia
Pancreatite Crônica/complicações
[Mh] Termos MeSH secundário: Creatinina/urina
Progressão da Doença
Feminino
Seguimentos
Taxa de Filtração Glomerular
Seres Humanos
Hiperoxalúria/epidemiologia
Hiperoxalúria/urina
Estudos Longitudinais
Masculino
Meia-Idade
Análise Multivariada
Proteínas de Transporte Nucleocitoplasmático/urina
Pacientes Ambulatoriais
Pancreatite Crônica/epidemiologia
Pancreatite Crônica/urina
Prevalência
Estudos Prospectivos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Nucleocytoplasmic Transport Proteins); 0 (oxalate binding protein, human); AYI8EX34EU (Creatinine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170612
[Lr] Data última revisão:
170612
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170511
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000006758


  4 / 802 MEDLINE  
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[PMID]:28442375
[Au] Autor:Bhardwaj R; Bhardwaj A; Tandon C; Dhawan DK; Bijarnia RK; Kaur T
[Ad] Endereço:Department of Biophysics, Panjab University, Chandigarh, India.
[Ti] Título:Implication of hyperoxaluria on osteopontin and ER stress mediated apoptosis in renal tissue of rats.
[So] Source:Exp Mol Pathol;102(3):384-390, 2017 Jun.
[Is] ISSN:1096-0945
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Hyperoxaluria is a stress that leads to calcium oxalate crystal deposition which further causes inflammation and renal cell necroptosis. Many studies have linked osteopontin expression with apoptosis and inflammation but so far its association with apoptosis with regard to hyperoxaluria is undiscovered. Moreover, a recent report has suggested that osteopontin induces endoplasmic reticulum stress and subsequently apoptosis in myocytes. In this study, the impact of hyperoxaluria on the modulation of osteopontin expression and endoplasmic reticulum (ER) stress mediated apoptosis in rats is explored. Hyperoxaluria was induced in rats by three different doses viz. ethylene glycol alone, ethylene glycol and ammonium chloride together and third group were fed with hydroxyl-l-proline. After hyperoxaluria induction rats were sacrificed and renal tissue was analysed for crystal depositions, osteopontin expression, inflammation, ER stress and subsequent unfolded protein response intermediates (UPR). Altered histoarchitecture of renal tissue and elevated levels of reactive oxygen species (ROS) along with the presence of calcium oxalate crystals were observed in the hyperoxaluric groups. As expected, inflammation and apoptosis was significantly high in all hyperoxaluria groups. Osteopontin expression showed significant up-regulation following hyperoxaluria. Further, a similar trend between expression of osteopontin and elevated ER stress level was observed. Moreover, UPR intermediates expression was also concurrent with osteopontin levels. It is observed that the extent of calcium oxalate crystal deposition is directly associated with the expression of osteopontin, inflammation and ER stress. The results advocate possible association of osteopontin with ER stress, thus suggesting that the ER could be a new target for developing therapeutic regimes for kidney stones.
[Mh] Termos MeSH primário: Apoptose
Estresse do Retículo Endoplasmático/genética
Hiperoxalúria/patologia
Rim/patologia
Osteopontina/metabolismo
[Mh] Termos MeSH secundário: Animais
Oxalato de Cálcio/metabolismo
Modelos Animais de Doenças
Proteínas de Choque Térmico/genética
Proteínas de Choque Térmico/metabolismo
Masculino
Osteopontina/genética
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Ratos
Ratos Wistar
Espécies Reativas de Oxigênio/metabolismo
Resposta a Proteínas não Dobradas
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Heat-Shock Proteins); 0 (Hspa5 protein, rat); 0 (RNA, Messenger); 0 (Reactive Oxygen Species); 0 (Spp1 protein, rat); 106441-73-0 (Osteopontin); 2612HC57YE (Calcium Oxalate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE


  5 / 802 MEDLINE  
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[PMID]:28392511
[Au] Autor:Jaturakan O; Dissayabutra T; Chaiyabutr N; Kijtawornrat A; Tosukhowong P; Rungsipipat A; Nhujak T; Buranakarl C
[Ad] Endereço:Department of Physiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand.
[Ti] Título:Combination of vitamin E and vitamin C alleviates renal function in hyperoxaluric rats via antioxidant activity.
[So] Source:J Vet Med Sci;79(5):896-903, 2017 May 18.
[Is] ISSN:1347-7439
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Hyperoxaluria and oxidative stress are risk factors in calcium oxalate (CaOx) stone formation. Supplement with antioxidant could be effective in prevention of recurrent stone formation. The present study aims to evaluate the protective effects of vitamin E and vitamin C in hyperoxaluric rat. The experiment was performed in rats for 21 days. Rats were divided into 5 groups as follows: control (group 1, n=8), hyperoxaluric rats (group 2, n=8), hyperoxaluric rats with vitamin E supplement (group 3, n=7), hyperoxaluric rats with vitamin C supplement (group 4, n=7) and hyperoxaluric rats with vitamin E and C supplement (group 5, n=7). Hyperoxaluria was induced by feeding hydroxyl L-proline (HLP) 2% w/v dissolved in drinking water. Intraperitoneal 200 mg/kg of vitamin E was given in groups 3 and 5 on days 1, 6, 11 and 16, while 500 mg of vitamin C was injected intravenously in groups 4 and 5 on days 1 and 11. Renal functions and oxidative status were measured. The urinary oxalate excretion was increased in HLP supplement rats, while glomerular filtration rate, proximal water and sodium reabsorption were significantly lower in group 2 compared with a control (P<0.05). Giving antioxidants significantly lower urinary calcium oxalate crystals (P<0.05). Hyperoxaluric rats had higher plasma malondialdehyde (PMDA) and lower urinary total antioxidant status (UTAS), which were alleviated by vitamin E and/or vitamin C supplement. In conclusion, giving combination of vitamin E and vitamin C exerts a protective role against HLP-induced oxalate nephropathy.
[Mh] Termos MeSH primário: Antioxidantes/uso terapêutico
Ácido Ascórbico/uso terapêutico
Hiperoxalúria/tratamento farmacológico
Rim/efeitos dos fármacos
Vitamina E/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Antioxidantes/administração & dosagem
Ácido Ascórbico/administração & dosagem
Peso Corporal
Citratos/urina
Ingestão de Líquidos
Quimioterapia Combinada
Ingestão de Alimentos
Eletrólitos/metabolismo
Hemodinâmica
Hiperoxalúria/patologia
Rim/patologia
Cálculos Renais/prevenção & controle
Glomérulos Renais/efeitos dos fármacos
Glomérulos Renais/fisiologia
Masculino
Oxalatos/urina
Substâncias Protetoras/uso terapêutico
Ratos
Ratos Sprague-Dawley
Vitamina E/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Citrates); 0 (Electrolytes); 0 (Oxalates); 0 (Protective Agents); 1406-18-4 (Vitamin E); PQ6CK8PD0R (Ascorbic Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE
[do] DOI:10.1292/jvms.17-0083


  6 / 802 MEDLINE  
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[PMID]:28261895
[Au] Autor:Villani V; Gupta N; Elias N; Vagefi PA; Markmann JF; Paul E; Traum AZ; Yeh H
[Ad] Endereço:Division of Transplant Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.
[Ti] Título:Bilateral native nephrectomy reduces systemic oxalate level after combined liver-kidney transplant: A case report.
[So] Source:Pediatr Transplant;21(3), 2017 May.
[Is] ISSN:1399-3046
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:Primary hyperoxaluria type 1 (PH1) is a rare liver enzymatic defect that causes overproduction of plasma oxalate. Accumulation of oxalate in the kidney and subsequent renal failure are fatal to PH1 patients often in pediatric age. Combined liver and kidney transplantation is the therapy of choice for end-stage renal disease due to PH1. Levels of plasma oxalate remain elevated for several months after liver transplantation, as the residual body oxalate is slowly excreted. Patients with persistent hyperoxaluria after transplant often require hemodialysis, and accumulation of residual oxalate in the kidney can induce graft dysfunction. As the native kidneys are the main target of calcium oxalate accumulation, we postulated that removal of native kidneys could drastically decrease total body oxalate levels after transplantation. Here, we report a case of bilateral nephrectomy at the time of combined liver-kidney transplantation in a pediatric PH1 patient. Bilateral nephrectomy induced a rapid decrease in plasma oxalate to normal levels in less than 20 days, compared to the several months reported in the literature. Our results suggest that removal of native kidneys could be an effective strategy to decrease the need for hemodialysis and the risk of renal dysfunction after combined liver-kidney transplantation in patients with PH1.
[Mh] Termos MeSH primário: Hiperoxalúria Primária/cirurgia
Falência Renal Crônica/cirurgia
Transplante de Rim/métodos
Transplante de Fígado/métodos
Oxalatos/sangue
[Mh] Termos MeSH secundário: Criança
Feminino
Taxa de Filtração Glomerular
Seres Humanos
Hiperoxalúria/sangue
Rim/fisiopatologia
Nefrectomia
Diálise Renal
Insuficiência Renal/complicações
[Pt] Tipo de publicação:CASE REPORTS
[Nm] Nome de substância:
0 (Oxalates)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE
[do] DOI:10.1111/petr.12901


  7 / 802 MEDLINE  
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[PMID]:28221143
[Au] Autor:Lancina Martín JA
[Ad] Endereço:Unidad de Litiasis. Servicio de Urología. Complejo Hospitalario Universitario de A Coruña. España.
[Ti] Título:[Metabolic study. How to make it accessible, useful and generalized.]
[Ti] Título:Estudio metabólico. Cómo hacerlo accesible, útil y generalizado..
[So] Source:Arch Esp Urol;70(1):71-90, 2017 Jan.
[Is] ISSN:0004-0614
[Cp] País de publicação:Spain
[La] Idioma:spa
[Ab] Resumo:Risk factors should be evaluated in all patients with urinary lithiasis. The kind of evaluation, simplified or extended, depends on stone composition and, in patients with calcium lithiasis, on the clinical presentation. These studies are done in an outpatient regimen, are easy to perform and accessible for most laboratories. Patients with uric acid, infectious and cystine stones only require a selective more abbreviated evaluation. In calcium lithiasis we perform an extended metabolic evaluation in recurrent patients and also in singleepisode patients when they have high recurrence risk. The extended evaluation has demonstrated to be costeffective in patients with highly recurrent lithiasis. There is not enough clinical evidence yet on what would be the most convenient study methodology for a proper metabolic evaluation, and proposed clinical guidelines are mainly based on expert committee opinions.With these studies, we can diagnose systemic and renal diseases of lithogenic nature, and they also enable the adoption of precise prophylactic measures that achieve recurrence control in a great number of patients.
[Mh] Termos MeSH primário: Urolitíase/diagnóstico
Urolitíase/metabolismo
[Mh] Termos MeSH secundário: Algoritmos
Cálcio/análise
Técnicas de Diagnóstico Urológico
Seres Humanos
Hipercalciúria/complicações
Hiperoxalúria/complicações
Anamnese
Medição de Risco
Fatores de Risco
Urolitíase/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
SY7Q814VUP (Calcium)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170222
[St] Status:MEDLINE


  8 / 802 MEDLINE  
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[PMID]:28221141
[Au] Autor:Arrabal-Martín M; Cano-García MC; Arrabal-Polo MÁ; Domínguez-Amillo A; Canales-Casco N; de la Torre-Trillo J; Cózar-Olmo JM
[Ad] Endereço:Unidad de Urolitiasis y Endourología. Servicio de Urología. Complejo Hospitalario Universitario Granada. España.
[Ti] Título:[Etiopathogenic factors of the different types of urinary litiasis.]
[Ti] Título:Factores etiopatogénicos de los diferentes tipos de urolitiasis..
[So] Source:Arch Esp Urol;70(1):40-50, 2017 Jan.
[Is] ISSN:0004-0614
[Cp] País de publicação:Spain
[La] Idioma:spa
[Ab] Resumo:In this review, we analyze the etiopathogenic principles of urinary lithiasis formation. In the kidney, calcifications that may cause renal lithiasis are produced as a consequence of processes that injury the urothelium at the papilla and Bellini's ducts. With the improvement of imaging techniques, mainly micro CT scan, it is possible to detect them and we may be able to anticipate to the formation of lithiasis. As we well know, there are different factors that influence the formation of the calculi depending on their composition. In calcium lithiasis it is key to review the modification of the categories of hypercalciuria, we currently distinguish two types instead of three, thanks to the fasting calcium/ creatinine ratio, differentiating absorptive hypercalciuria and fasting hypercalciuria. In the fasting hypercalciuria, it is important to emphasize the relationship between this factor and the loss of bone mineral density in patients with recurrent renal calcic lithiasis, so that in this kind of patients it is compulsory the study of bone metabolism by bone remodelling markers and bone densitometry. Regarding the other factors that participate in the formation of calcium lithiasis we should specially emphasize on hypercalciuria and its growing increase because of its relationship with obesity and metabolic syndrome, as well as hipocitraturia, present in an important percentage of patients and related in some cases with metabolic acidosis and osteopenia-osteoporosis too. In relation to uric acid lithiasis it should be highlighted that urinary pH is the most determinant factor and, therefore, its control and modifications would be paramount for prevention of this type of lithiasis. In the infectious lithiasis, the presence of germs that split urea is mandatory. They generate ammonia ions with the ability to injure the urothelium and to form magnesium ammonium phosphate lithiasis mainly. Regarding cystine lithiasis, rare, it was classically divided in three types and now passed to be classified in type A and B depending on the muted gene, and it is more useful to perform direct 24-hour urine measurement than screening tests which have low sensitivity. In general, we tried to give a comprehensive view of the various types of lithiasis emphasizing the most interesting clinical points for the urologist.
[Mh] Termos MeSH primário: Urolitíase/etiologia
[Mh] Termos MeSH secundário: Algoritmos
Cálcio/análise
Seres Humanos
Hiperoxalúria/complicações
Cálculos Renais/química
Cálculos Renais/classificação
Cálculos Renais/patologia
Ácido Úrico/análise
Urolitíase/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
268B43MJ25 (Uric Acid); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170222
[St] Status:MEDLINE


  9 / 802 MEDLINE  
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[PMID]:28089681
[Au] Autor:Moreland AM; Santa Ana CA; Asplin JR; Kuhn JA; Holmes RP; Cole JA; Odstrcil EA; Van Dinter TG; Martinez JG; Fordtran JS
[Ad] Endereço:Division of Gastroenterology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas.
[Ti] Título:Steatorrhea and Hyperoxaluria in Severely Obese Patients Before and After Roux-en-Y Gastric Bypass.
[So] Source:Gastroenterology;152(5):1055-1067.e3, 2017 Apr.
[Is] ISSN:1528-0012
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: Hyperoxaluria after Roux-en-Y gastric bypass (RYGB) is generally attributed to fat malabsorption. If hyperoxaluria is indeed caused by fat malabsorption, magnitudes of hyperoxaluria and steatorrhea should correlate. Severely obese patients, prior to bypass, ingest excess dietary fat that can produce hyperphagic steatorrhea. The primary objective of the study was to determine whether urine oxalate excretion correlates with elements of fat balance in severely obese patients before and after RYGB. METHODS: Fat balance and urine oxalate excretion were measured simultaneously in 26 severely obese patients before and 1 year after RYGB, while patients consumed their usual diet. At these time points, stool and urine samples were collected. Steatorrhea and hyperoxaluria were defined as fecal fat >7 g/day and urine oxalate >40 mg/day. Differences were evaluated using paired 2-tailed t tests. RESULTS: Prior to RYGB, 12 of 26 patients had mild to moderate steatorrhea. Average urine oxalate excretion was 61 mg/day; there was no correlation between fecal fat and urine oxalate excretion. After RYGB, 24 of 26 patients had steatorrhea and urine oxalate excretion averaged 69 mg/day, with a positive correlation between fecal fat and urine oxalate excretions (r = 0.71, P < .001). For each 10 g/day increase in fecal fat output, fecal water excretion increased only 46 mL/day. CONCLUSIONS: Steatorrhea and hyperoxaluria were common in obese patients before bypass, but hyperoxaluria was not caused by excess unabsorbed fatty acids. Hyperphagia, obesity, or metabolic syndrome could have produced this previously unrecognized hyperoxaluric state by stimulating absorption or endogenous synthesis of oxalate. Hyperoxaluria after RYGB correlated with steatorrhea and was presumably caused by excess fatty acids in the intestinal lumen. Because post-bypass steatorrhea caused little increase in fecal water excretion, most patients with steatorrhea did not consider themselves to have diarrhea. Before and after RYGB, high oxalate intake contributed to the severity of hyperoxaluria.
[Mh] Termos MeSH primário: Gorduras na Dieta/metabolismo
Derivação Gástrica
Hiperoxalúria/metabolismo
Hiperfagia/metabolismo
Obesidade/metabolismo
Esteatorreia/metabolismo
[Mh] Termos MeSH secundário: Adulto
Idoso
Fezes/química
Feminino
Seres Humanos
Hiperoxalúria/epidemiologia
Masculino
Meia-Idade
Obesidade/epidemiologia
Obesidade/cirurgia
Oxalatos/urina
Índice de Gravidade de Doença
Esteatorreia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Fats); 0 (Oxalates)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170117
[St] Status:MEDLINE


  10 / 802 MEDLINE  
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[PMID]:27956392
[Au] Autor:Bernardino M; Parmar MS
[Ad] Endereço:Timmins and District Hospital (Bernardino, Parmar), Timmins, Ont.; Division of Clinical Sciences (Parmar), Northern Ontario School of Medicine, Sudbury and Thunder Bay, Ont.
[Ti] Título:Oxalate nephropathy from cashew nut intake.
[So] Source:CMAJ;189(10):E405-E408, 2017 03 13.
[Is] ISSN:1488-2329
[Cp] País de publicação:Canada
[La] Idioma:eng
[Mh] Termos MeSH primário: Anacardium
Hiperoxalúria/induzido quimicamente
Nozes/química
Oxalatos/efeitos adversos
Insuficiência Renal Crônica/etiologia
[Mh] Termos MeSH secundário: Carbonato de Cálcio/uso terapêutico
Quelantes/uso terapêutico
Feminino
Seres Humanos
Hiperoxalúria/complicações
Meia-Idade
Insuficiência Renal Crônica/tratamento farmacológico
Insuficiência Renal Crônica/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chelating Agents); 0 (Oxalates); H0G9379FGK (Calcium Carbonate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161214
[St] Status:MEDLINE
[do] DOI:10.1503/cmaj.151327



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