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Pesquisa : C12.777.419.403.875 [Categoria DeCS]
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  1 / 5186 MEDLINE  
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[PMID]:29394475
[Au] Autor:Pazmiño PA
[Ad] Endereço:Nephrology, Internal Medicine, and Hypertension Center, El Paso, TX drppazmino@msn.com
[Ti] Título:Tolvaptan in Later-Stage Polycystic Kidney Disease.
[So] Source:N Engl J Med;378(5):488-9, 2018 02 01.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Antagonistas de Receptores de Hormônios Antidiuréticos
Benzazepinas
[Mh] Termos MeSH secundário: Seres Humanos
Rim
Doenças Renais Policísticas
Rim Policístico Autossômico Dominante
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
0 (Antidiuretic Hormone Receptor Antagonists); 0 (Benzazepines); 21G72T1950 (tolvaptan)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMc1716478


  2 / 5186 MEDLINE  
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[PMID]:29394474
[Au] Autor:De Tymowski C; Legrand M
[Ad] Endereço:Hôpital Saint-Louis, Paris, France
[Ti] Título:Tolvaptan in Later-Stage Polycystic Kidney Disease.
[So] Source:N Engl J Med;378(5):488, 2018 02 01.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Antagonistas de Receptores de Hormônios Antidiuréticos
Benzazepinas
[Mh] Termos MeSH secundário: Seres Humanos
Rim
Doenças Renais Policísticas
Rim Policístico Autossômico Dominante
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
0 (Antidiuretic Hormone Receptor Antagonists); 0 (Benzazepines); 21G72T1950 (tolvaptan)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMc1716478


  3 / 5186 MEDLINE  
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[PMID]:29385372
[Au] Autor:Torres VE; Gansevoort RT; Czerwiec FS
[Ad] Endereço:Mayo Clinic, Rochester, MN torres.vicente@mayo.edu
[Ti] Título:Tolvaptan in Later-Stage Polycystic Kidney Disease.
[So] Source:N Engl J Med;378(5):489-490, 2018 02 01.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Antagonistas de Receptores de Hormônios Antidiuréticos
Benzazepinas
[Mh] Termos MeSH secundário: Seres Humanos
Rim
Doenças Renais Policísticas
Rim Policístico Autossômico Dominante
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
0 (Antidiuretic Hormone Receptor Antagonists); 0 (Benzazepines); 21G72T1950 (tolvaptan)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMc1716478


  4 / 5186 MEDLINE  
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[PMID]:29069013
[Au] Autor:Mi YX; Sui X; Huang JM; Wei LG; Xie P
[Ad] Endereço:aDepartment of Nuclear Medicine, Shanxi Provincial Cancer Hospital, Taiyuan City bDepartment of Ultrasound cDepartment of Nuclear Medicine, The Third Hospital, Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
[Ti] Título:Incidentally polycystic kidney disease identified by SPECT/CT with post-therapy radioiodine scintigraphy in a patient with differentiated thyroid carcinoma: A case report.
[So] Source:Medicine (Baltimore);96(43):e8348, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Post-therapy or diagnostic whole-body radioiodine scintigraphy is widely employed to evaluate the residual, recurrence, or metastases of differentiated thyroid carcinoma because of the high sensitivity and accuracy. However, it has pitfalls. PATIENT CONCERNS: We described a 63-year-old male with a history of papillary thyroid carcinoma who was referred for iodine-131 ablation therapy. The post-therapy iodine-131 whole-body images demonstrated abnormal increased uptake of the tracer in the regions of bilateral upper abdomen. DIAGNOSES: The single photon emission computed tomography/computed tomography (SPECT/CT) showed the abnormal Iactivity was corresponded to multiple irregular cystic low densities in the both kidneys on the low-dose computed tomography images, so the diagnosis of polycystic kidney disease was confirmed. INTERVENTIONS AND OUTCOMES: The patient responded well to the lifestyle-based treatments. LESSONS: Polycystic kidney disease was one of the etiologies of the false-positive findings in the radioiodine scintigraphy.
[Mh] Termos MeSH primário: Carcinoma Papilar
Doenças Renais Policísticas/diagnóstico
Radioimunoterapia/métodos
Tomografia Computadorizada com Tomografia Computadorizada de Emissão de Fóton Único/métodos
Neoplasias da Glândula Tireoide
[Mh] Termos MeSH secundário: Carcinoma Papilar/patologia
Carcinoma Papilar/terapia
Seres Humanos
Achados Incidentais
Radioisótopos do Iodo/uso terapêutico
Masculino
Meia-Idade
Metástase Neoplásica/diagnóstico
Compostos Radiofarmacêuticos/uso terapêutico
Neoplasias da Glândula Tireoide/patologia
Neoplasias da Glândula Tireoide/terapia
Imagem Corporal Total/métodos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iodine Radioisotopes); 0 (Radiopharmaceuticals)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171123
[Lr] Data última revisão:
171123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008348


  5 / 5186 MEDLINE  
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[PMID]:29064957
[Au] Autor:Grodstein EI; Baggett N; Wayne S; Leverson G; D'Alessandro AM; Fernandez LA; Foley DP; Mezrich JD; Odorico JS; Redfield RR; Sollinger HW; Kaufman DB
[Ad] Endereço:1 Division of Transplantation, Department of Surgery, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, Madison, WI.
[Ti] Título:An Evaluation of the Safety and Efficacy of Simultaneous Bilateral Nephrectomy and Renal Transplantation for Polycystic Kidney Disease: A 20-Year Experience.
[So] Source:Transplantation;101(11):2774-2779, 2017 Nov.
[Is] ISSN:1534-6080
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Many strategies regarding timing of native nephrectomies exist for patients with symptomatic polycystic kidney disease (PCKD). METHODS: This is a single-center, retrospective study of 594 adults with PCKD who had renal transplants from 1994 to 2014. Three groups were analyzed: renal transplant-only recipients (tx alone), recipients of simultaneous bilateral nephrectomies and transplant (simultaneous), and recipients with pretransplant bilateral nephrectomies (pre). The primary outcome was graft survival. Secondary outcomes included postoperative complications. RESULTS: Five hundred sixty-five adults with PCKD received kidney transplants (303 tx alone, 161 simultaneous, 27 pre). Ten-year posttransplant graft survival was 68.5%, 63.6%, and 65.7% for tx alone, simultaneous, and precohorts (P = 0.86). No statistically significant differences were observed in rates of postoperative ileus, deep vein thrombosis, small bowel obstruction, urinary stricture, urine leak, hernia formation, and delayed graft function. More wound complications were seen in prepatients (25.9% vs 11.1% tx alone, 5.1% simultaneous; P = 0.03), whereas simultaneous patients had a lower incidence of lymphocele (1.3% vs 11.1% pre, 10.2% tx-alone; P = 0.002). Importantly, simultaneous patients had more renal vascular thromboses (4.4% vs 1.3% tx alone, 0% pre; P = 0.04). 16.3% of renal transplant alone patients required nephrectomy at 10 years follow-up. Twenty-nine patients were referred for transplant having had nephrectomies and were ultimately not transplanted. In 4 of these patients who had data available for analysis, the mean panel-reactive antibody significantly increased after nephrectomy was performed. CONCLUSIONS: Simultaneous bilateral nephrectomy can be safely performed at the time of renal transplantation, however, carries a significantly increased risk of renal vascular thrombosis.
[Mh] Termos MeSH primário: Transplante de Rim
Nefrectomia
Doenças Renais Policísticas/cirurgia
Tempo para o Tratamento
[Mh] Termos MeSH secundário: Feminino
Sobrevivência de Enxerto
Seres Humanos
Estimativa de Kaplan-Meier
Transplante de Rim/efeitos adversos
Masculino
Meia-Idade
Nefrectomia/efeitos adversos
Doenças Renais Policísticas/diagnóstico
Complicações Pós-Operatórias/etiologia
Estudos Retrospectivos
Fatores de Risco
Fatores de Tempo
Resultado do Tratamento
Wisconsin
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171025
[St] Status:MEDLINE
[do] DOI:10.1097/TP.0000000000001779


  6 / 5186 MEDLINE  
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[PMID]:28978659
[Au] Autor:Nurmonen HJ; Huttunen T; Huttunen J; Kurki MI; Helin K; Koivisto T; von Und Zu Fraunberg M; Jääskeläinen JE; Lindgren AE
[Ad] Endereço:From Neurosurgery (H.J.N.), School of Medicine, Institute of Clinical Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio; Neurosurgery of NeuroCenter (T.H., J.H., K.H., T.K., M.v.u.z.F., J.E.J. A.E.L.), Kuopio University Hospital, Finland; and Broad Institute (M.I.K.), Bosto
[Ti] Título:Polycystic kidney disease among 4,436 intracranial aneurysm patients from a defined population.
[So] Source:Neurology;89(18):1852-1859, 2017 Oct 31.
[Is] ISSN:1526-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To define the association of autosomal dominant polycystic kidney disease (ADPKD) with the characteristics of aneurysmal subarachnoid hemorrhage (aSAH) and unruptured intracranial aneurysm (IA) disease. METHODS: We fused data from the Kuopio Intracranial Aneurysm database (n = 4,436 IA patients) and Finnish nationwide registries into a population-based series of 53 IA patients with ADPKD to compare the aneurysm- and patient-specific characteristics of IA disease in ADPKD and in the general IA population, and to identify risks for de novo IA formation. RESULTS: In total, there were 33 patients with ADPKD with aSAH and 20 patients with ADPKD with unruptured IAs. The median size of ruptured IAs in ADPKD was significantly smaller than in the general population (6.00 vs 8.00 mm) and the proportion of small ruptured IAs was significantly higher (31% vs 18%). Median age at aSAH was 42.8 years, 10 years younger than in the general IA population. Multiple IAs were present in 45% of patients with ADPKD compared to 28% in the general IA population. Cumulative risk of de novo IA formation was 1.3% per patient-year (vs 0.2% in the general IA population). Hazard for de novo aneurysm formation was significantly elevated in patients with ADPKD (Cox regression hazard ratio 7.7, 95% confidence interval 2.8-20; < 0.0005). CONCLUSIONS: Subarachnoid hemorrhage occurs at younger age and from smaller IAs in patients with ADPKD and risk for de novo IAs is higher than in the general Eastern Finnish population. ADPKD should be considered as an indicator for long-term angiographic follow-up in patients with diagnosed IAs.
[Mh] Termos MeSH primário: Aneurisma Intracraniano/epidemiologia
Doenças Renais Policísticas/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Área Programática (Saúde)
Planejamento em Saúde Comunitária
Bases de Dados Factuais
Feminino
Finlândia/epidemiologia
Seguimentos
Seres Humanos
Incidência
Aneurisma Intracraniano/complicações
Aneurisma Intracraniano/diagnóstico por imagem
Estimativa de Kaplan-Meier
Masculino
Meia-Idade
Doenças Renais Policísticas/complicações
Doenças Renais Policísticas/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000004597


  7 / 5186 MEDLINE  
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[PMID]:28855402
[Au] Autor:Yu TM; Chuang YW; Sun KT; Yu MC; Kung SC; Lee BK; Huang ST; Chen CH; Lin CL; Kao CH
[Ad] Endereço:From the Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine (T.-M.Y., K.-T.S., S.-T.H., C.-H.C., C.-H.K.), Pediatric Dentistry, Dental Department (K.-T.S.), and College of Medicine (C.-L.L.), China Medical University, Taichung; Division of Nephrology (T.-M.Y.,
[Ti] Título:Polycystic kidney disease is significantly associated with dementia risk.
[So] Source:Neurology;89(14):1457-1463, 2017 Oct 03.
[Is] ISSN:1526-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Data on the risk of neurodegenerative diseases, including Alzheimer disease (AD) and Parkinson disease (PD), in patients with polycystic kidney disease (PKD) are lacking. METHODS: A total of 4,229 patients who were aged ≥20 years and had received a diagnosis of PKD were included in the PKD cohort. For each PKD case identified, 1 participant aged ≥20 years without a history of PKD, dementia, or PD was selected from the comparison cohort. For each patient with PKD, the corresponding controls were selected 1:1 on the basis of the nearest propensity score calculated using logistic regression. RESULTS: The incidence density rates of dementia were 4.31 and 2.50 per 1,000 person-years in the PKD and control cohorts, respectively. A 2.04-fold higher risk of dementia was observed in patients with PKD than in controls (adjusted hazard ratio [aHR] 2.04; 95% confidence interval [CI] 1.46-2.85). Regarding the risk of different dementia subtypes, including AD and vascular dementia (VaD), the aHR for AD and presenile dementia was 2.71 (95% CI 1.08-6.75) and that for VaD was 0.90 (95% CI 0.43-1.87) in patients with PKD compared with controls, after adjustment for age, sex, and comorbidities. Compared with controls, the risk of PD increased by 1.78-fold (95% CI 1.14-2.79) in patients with PKD. CONCLUSIONS: In clinical practice, health care professionals should be aware of the risk of neurodegenerative diseases in patients with PKD.
[Mh] Termos MeSH primário: Demência/epidemiologia
Doenças Renais Policísticas/epidemiologia
[Mh] Termos MeSH secundário: Fatores Etários
Idoso
Estudos de Coortes
Comorbidade
Demência/classificação
Feminino
Seres Humanos
Incidência
Masculino
Meia-Idade
Mutação/genética
Doenças Renais Policísticas/genética
Modelos de Riscos Proporcionais
Fatores de Risco
Canais de Cátion TRPP/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (TRPP Cation Channels); 0 (polycystic kidney disease 1 protein)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000004434


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[PMID]:28823919
[Au] Autor:Kobayashi D; Asano-Hoshino A; Nakakura T; Nishimaki T; Ansai S; Kinoshita M; Ogawa M; Hagiwara H; Yokoyama T
[Ad] Endereço:Department of Anatomy and Developmental Biology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. Electronic address: kdaisuke@koto.kpu-m.ac.jp.
[Ti] Título:Loss of zinc finger MYND-type containing 10 (zmynd10) affects cilia integrity and axonemal localization of dynein arms, resulting in ciliary dysmotility, polycystic kidney and scoliosis in medaka (Oryzias latipes).
[So] Source:Dev Biol;430(1):69-79, 2017 10 01.
[Is] ISSN:1095-564X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cilia and flagella are hair-like organelles that project from the cell surface and play important roles in motility and sensory perception. Motility defects in cilia and flagella lead to primary ciliary dyskinesia (PCD), a rare human disease. Recently zinc finger MYND-type containing 10 (ZMYND10) was identified in humans as a PCD-associated gene. In this study, we use medaka fish as a model to characterize the precise functions of zmynd10. In medaka, zmynd10 is exclusively expressed in cells with motile cilia. Embryos with zmynd10 Morpholino knockdown exhibited a left-right (LR) defect associated with loss of motility in Kupffer's vesicle (KV) cilia. This immotility was caused by loss of the outer dynein arms, which is a characteristic ultrastructural phenotype in PCD. In addition, KV cilia in zmynd10 knockdown embryos had a swollen and wavy morphology. Together, these results suggest that zmynd10 is a multi-functional protein that has independent roles in axonemal localization of dynein arms and in formation and/or maintenance of cilia. The C-terminal region of zmynd10 has a MYND-type zinc finger domain (zf-MYND) that is important for its function. Our rescue experiment showed that the zmynd10-ΔC truncated protein, which lacks zf-MYND, was still partially functional, suggesting that zmynd10 has another functional domain besides zf-MYND. To analyze the later stages of development, we generated a zmynd10 knockout mutant using transcription activator-like effector nuclease (TALEN) technology. Adult mutants exhibited sperm dysmotility, scoliosis and progressive polycystic kidney.
[Mh] Termos MeSH primário: Axonema/metabolismo
Cílios/metabolismo
Dineínas/metabolismo
Oryzias/metabolismo
Doenças Renais Policísticas/metabolismo
Escoliose/metabolismo
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Axonema/efeitos dos fármacos
Sequência de Bases
Padronização Corporal/efeitos dos fármacos
Padronização Corporal/genética
Cílios/efeitos dos fármacos
Embrião não Mamífero/efeitos dos fármacos
Embrião não Mamífero/metabolismo
Epistasia Genética/efeitos dos fármacos
Regulação da Expressão Gênica no Desenvolvimento/efeitos dos fármacos
Masculino
Morfolinos/farmacologia
Movimento
Oryzias/embriologia
Oryzias/genética
Fenótipo
Doenças Renais Policísticas/patologia
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Escoliose/patologia
Espermatozoides/metabolismo
Proteínas Supressoras de Tumor/química
Proteínas Supressoras de Tumor/genética
Proteínas Supressoras de Tumor/metabolismo
Dedos de Zinco
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Morpholinos); 0 (RNA, Messenger); 0 (Tumor Suppressor Proteins); EC 3.6.4.2 (Dyneins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170822
[St] Status:MEDLINE


  9 / 5186 MEDLINE  
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[PMID]:28692371
[Au] Autor:Shahid S; Rait S; Sharples E; Gorard D
[Ad] Endereço:Gastroenterology Registrar, Gastroenterology Office, Wycombe Hospital, Buckinghamshire Healthcare NHS Trust, High Wycombe HP11 2TT.
[Ti] Título:Chronic hepatitis in the transplant patient.
[So] Source:Br J Hosp Med (Lond);78(7):408-409, 2017 Jul 02.
[Is] ISSN:1750-8460
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Rejeição de Enxerto/prevenção & controle
Hepatite E/diagnóstico
Hepatite Crônica/diagnóstico
Imunossupressores/efeitos adversos
Transplante de Rim
Doenças Renais Policísticas/cirurgia
[Mh] Termos MeSH secundário: Idoso
Alanina Transaminase/sangue
Antivirais/uso terapêutico
Hepatite E/sangue
Hepatite E/tratamento farmacológico
Hepatite E/etiologia
Vírus da Hepatite E/genética
Vírus da Hepatite E/imunologia
Hepatite Crônica/sangue
Hepatite Crônica/tratamento farmacológico
Hepatite Crônica/etiologia
Seres Humanos
Hospedeiro Imunocomprometido
Imunoglobulina M/sangue
Masculino
Ácido Micofenólico/efeitos adversos
Reação em Cadeia da Polimerase
RNA Viral/sangue
Ribavirina/uso terapêutico
Tacrolimo/efeitos adversos
Carga Viral
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Immunoglobulin M); 0 (Immunosuppressive Agents); 0 (RNA, Viral); 49717AWG6K (Ribavirin); EC 2.6.1.2 (Alanine Transaminase); HU9DX48N0T (Mycophenolic Acid); WM0HAQ4WNM (Tacrolimus)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170711
[St] Status:MEDLINE
[do] DOI:10.12968/hmed.2017.78.7.408


  10 / 5186 MEDLINE  
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[PMID]:28666097
[Au] Autor:Kito Y; Saigo C; Takeuchi T
[Ad] Endereço:Department of Pathology and Translational Research, Gifu University Graduate School of Medicine, Gifu, Japan. Electronic address: kitoysk@gifu-u.ac.jp.
[Ti] Título:Novel Transgenic Mouse Model of Polycystic Kidney Disease.
[So] Source:Am J Pathol;187(9):1916-1922, 2017 Sep.
[Is] ISSN:1525-2191
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Transmembrane protein 207 (TMEM207) is characterized as an important molecule for invasiveness of gastric signet-ring cell carcinoma cells. To clarify the pathobiological effects of TMEM207, we generated 13 transgenic mouse strains, designated C57BL/6-transgenic (Tg) (ITF-TMEM207), where the mouse Tmem207 is ectopically expressed under the proximal promoter of the murine intestinal trefoil factor gene. A C57BL/6-Tg (ITF-TMEM207) mouse strain unexpectedly exhibited a high incidence of spontaneous kidney cysts with histopathological features resembling human polycystic kidney disease, which were found in approximately all mice within 1 year. TMEM207 immunoreactivity was found in noncystic kidney tubules and in renal cysts of the transgenic mice. The ITF-TMEM207 construct was inserted into Mitf at chromosome 6. Cystic kidney was not observed in other C57BL/6-Tg (ITF-TMEM207) transgenic mouse strains. Although several genetically manipulated animal models exist, this mouse strain harboring a genetic mutation in Mitf and overexpression of Tmem207 protein was not reported as a model of polycystic kidney disease until now. This study demonstrates that the C57BL/6-Tg (ITF-TMEM207) mouse may be a suitable model for understanding human polycystic kidney disease.
[Mh] Termos MeSH primário: Modelos Animais de Doenças
Rim/patologia
Proteínas de Membrana/genética
Doenças Renais Policísticas/genética
Doenças Renais Policísticas/patologia
[Mh] Termos MeSH secundário: Animais
Camundongos
Camundongos Transgênicos
Regiões Promotoras Genéticas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Membrane Proteins); 0 (TMEM207 protein, mouse)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde