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Pesquisa : C12.777.419.570.363 [Categoria DeCS]
Referências encontradas : 22996 [refinar]
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  1 / 22996 MEDLINE  
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[PMID]:29489695
[Au] Autor:Wang Y; Yan Y; Sui Z; Dong B; Zuo L
[Ti] Título:A case report of POEMS syndrome with renal involvement as immunotactoid glomerulopathy.
[So] Source:Medicine (Baltimore);97(9):e9920, 2018 Mar.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: POEMS syndrome is a rare multi-system disorder, which sometimes involves the kidney. Immunotactoid glomerulopathy (ITG) is an uncommon glomerular disease resulted from deposits of immunoglobulins and its derivatives. ITG caused by POEMS syndrome is rarely reported. PATIENT CONCERNS: A 63-year-old man was presented with acute kidney injury. In addition, it's found that he had abnormal serum free κ /λ ratio, polyneuropathy, Castleman's disease, organomegaly, endocrinopathy and skin changes. DIAGNOSES: POEMS syndrome was diagnosed, Renal biopsy revealed an ITG. INTERVENTIONS: Dexamethasone and thalidomide were given, as well as hemodialysis and other supportive treatments. OUTCOMES: The patient's extrarenal manifestations improved gradually and his renal function also showed slight improvement. LESSONS: ITG caused by POEMS syndrome is rare, however, it makes sense that the monoclonal proteins produced by the plasma cells could cause ITG. Chemotherapy similar to that employed in multiple myeloma may be beneficial for these patients.
[Mh] Termos MeSH primário: Glomerulonefrite/etiologia
Nefropatias/etiologia
Síndrome POEMS/complicações
[Mh] Termos MeSH secundário: Glomerulonefrite/patologia
Seres Humanos
Nefropatias/patologia
Glomérulos Renais/patologia
Masculino
Meia-Idade
Síndrome POEMS/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180301
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009920


  2 / 22996 MEDLINE  
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[PMID]:29397599
[Au] Autor:Chen Z; Yang YJ; Li J; Tian XP
[Ad] Endereço:Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China.
[Ti] Título:[The clinical characteristics of Takayasu's arteritis with glomerulonephropathy].
[So] Source:Zhonghua Nei Ke Za Zhi;57(2):129-133, 2018 Feb 01.
[Is] ISSN:0578-1426
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To investigate the clinical features of Takayasu's arteritis (TAK) with glomerulonephropathy and to improve physicians' understanding of this complication in patients with TAK. Clinical data were retrospectively collected including manifestations, laboratory tests, image findings and treatment of 8 patients diagnosed as Takayasu's arteritis with glomerulonephropathy from January 2002 to January 2017 in Peking Union Medical College Hospital. Glomerulonephropathy was confirmed based on percutaneous renal biopsy. There were 6 women and 2 men. The median onset age and median disease duration were 24 (18-37) years and 42 (3-360) months, respectively. Five patients had hypertension. The 24 hour urinary protein was 0.18-14.91 g. Red blood cells and casts in urine were tested among 4 and 2 patients, respectively. Three patients had renal artery stenosis. Three patients demonstrated mesangial proliferative glomerulonephritis, two with IgA nephropathy, two with minimal change disease and one with membranoproliferative glomerulonephritis. Seven patients received glucocorticoid combined with cyclophosphamide therapy (glucocorticoid 40-60 mg/d, prednisone or equivalent; cyclophosphamide 0.4 g/week iv. or cyclophosphamide 0.1 g/d po.). Uninary blood cells removed and 24 hour urinary protein decreased from 1.65 g to 0.90 g after treatment for 12 months in one patient. The other 7 patients were missing. Glomerulonephropathy is occasionally observed among TAK patients. Mesangial proliferative glomerulonephritis is the most common pathological subtype. Glucocorticoid combined with cyclophosphamide therapy could be an optional therapy for Takayasu's arteritis with glomerulonephropathy.
[Mh] Termos MeSH primário: Glomerulonefrite Membranoproliferativa/etiologia
Glomerulonefrite/etiologia
Arterite de Takayasu/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Ciclofosfamida/administração & dosagem
Ciclofosfamida/uso terapêutico
Eritrócitos
Feminino
Glomerulonefrite/patologia
Glomerulonefrite por IGA
Glomerulonefrite Membranoproliferativa/patologia
Glucocorticoides/administração & dosagem
Glucocorticoides/uso terapêutico
Seres Humanos
Hipertensão
Masculino
Prednisona/administração & dosagem
Prednisona/uso terapêutico
Arterite de Takayasu/complicações
Arterite de Takayasu/tratamento farmacológico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids); 8N3DW7272P (Cyclophosphamide); VB0R961HZT (Prednisone)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180206
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0578-1426.2018.02.009


  3 / 22996 MEDLINE  
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[PMID]:29208248
[Au] Autor:Sanghera P; Ghanta M; Ozay F; Ariyamuthu VK; Tanriover B
[Ad] Endereço:Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas.
[Ti] Título:Kidney Diseases Associated With Alternative Complement Pathway Dysregulation and Potential Treatment Options.
[So] Source:Am J Med Sci;354(6):533-538, 2017 12.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Atypical hemolytic uremic syndrome and C3 glomerulopathy (dense deposit disease and C3 glomerulonephritis) are characterized as inappropriate activation of the alternative complement pathway. Genetic mutations affecting the alternative complement pathway regulating proteins (complement factor H, I, membrane cofactor protein and complement factor H-related proteins) and triggers (such as infection, surgery, pregnancy and autoimmune disease flares) result in the clinical manifestation of these diseases. A decade ago, prognosis of these disease states was quite poor, with most patients developing end-stage renal disease. Furthermore, renal transplantation in these conditions was associated with poor outcomes due to graft loss to recurrent disease. Recent advances in targeted complement inhibitor therapy resulted in significant improvement in disease remission, renal recovery, health-related quality of life and allograft survival.
[Mh] Termos MeSH primário: Via Alternativa do Complemento/fisiologia
Nefropatias/etiologia
[Mh] Termos MeSH secundário: Síndrome Hemolítico-Urêmica Atípica/tratamento farmacológico
Síndrome Hemolítico-Urêmica Atípica/etiologia
Inativadores do Complemento/uso terapêutico
Via Alternativa do Complemento/efeitos dos fármacos
Glomerulonefrite/tratamento farmacológico
Glomerulonefrite/etiologia
Glomerulonefrite Membranoproliferativa/tratamento farmacológico
Glomerulonefrite Membranoproliferativa/etiologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Complement Inactivating Agents)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


  4 / 22996 MEDLINE  
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[PMID]:29390440
[Au] Autor:Li XL; Xu PC; Chen T; Yan TK; Jiang JQ; Jia JY; Wei L; Shang WY; Hu SY
[Ad] Endereço:Department of Nephrology.
[Ti] Título:Myeloperoxidase-antineutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis developed from ANCA negative renal limited vasculitis: A case report.
[So] Source:Medicine (Baltimore);96(51):e9128, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: The relationship between antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) and ANCA-negative vasculitis has not been elucidated. PATIENT CONCERNS: A 64-year-old female with edema and proteinuria was admitted. A kidney biopsy indicated focal proliferative nephritis with crescents in 25% of glomeruli. Serum ANCA was negative. Eighteen months later, systemic symptoms emerged and acute kidney injury occurred. Serum ANCA against myeloperoxidase (MPO) turned positive. Repeated kidney biopsy showed more severe lesion than last time. Immunoglobulin (Ig)G was purified from serum obtained before the first kidney biopsy. Weak ANCA which could not be detected in serum was found in IgG. DIAGNOSES: MPO-ANCA-associated AAV developed from ANCA-negative renal-limited AAV. INTERVENTIONS: The patient was treated with glucocorticoid. OUTCOMES: The serum creatinine decreased to 2.17 mg/dL a week later. MPO-ANCA turned negative when re-examined 3 weeks later. No relapse has been observed during follow-up for 6 months. LESSONS: This is the first reported case about the spontaneous transformation from ANCA-negative renal-limited AAV to ANCA-positive systemic vasculitis. There might be a slow process of epitope spreading in the pathogenesis of disease. Physicians should try their best to detect the ANCA in the diagnose and treatment of ANCA-negative AAV.
[Mh] Termos MeSH primário: Vasculite Associada a Anticorpo Anticitoplasma de Neutrófilos/diagnóstico
Anticorpos Anticitoplasma de Neutrófilos/sangue
Glomerulonefrite/etiologia
Peroxidase/imunologia
[Mh] Termos MeSH secundário: Lesão Renal Aguda/etiologia
Feminino
Glomerulonefrite/diagnóstico
Seres Humanos
Meia-Idade
Proteinúria/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Antineutrophil Cytoplasmic); EC 1.11.1.7 (Peroxidase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009128


  5 / 22996 MEDLINE  
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[PMID]:29315316
[Au] Autor:Dick J; Gan PY; Kitching AR; Holdsworth SR
[Ad] Endereço:Centre for Inflammatory Diseases, Monash University Department of Medicine, Clayton, Victoria, Australia.
[Ti] Título:The C3aR promotes macrophage infiltration and regulates ANCA production but does not affect glomerular injury in experimental anti-myeloperoxidase glomerulonephritis.
[So] Source:PLoS One;13(1):e0190655, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitides are autoimmune diseases associated with significant morbidity and mortality. They often affect the kidney causing rapidly progressive glomerulonephritis. While signalling by complement anaphylatoxin C5a though the C5a receptor is important in this disease, the role of the anaphylatoxin C3a signalling via the C3a receptor (C3aR) is not known. Using two different murine models of anti-myeloperoxidase (MPO) glomerulonephritis, one mediated by passive transfer of anti-MPO antibodies, the other by cell-mediated immunity, we found that the C3aR did not alter histological disease severity. However, it promoted macrophage recruitment to the inflamed glomerulus and inhibited the generation of MPO-ANCA whilst not influencing T cell autoimmunity. Thus, whilst the C3aR modulates some elements of disease pathogenesis, overall it is not critical in effector responses and glomerular injury caused by autoimmunity to MPO.
[Mh] Termos MeSH primário: Anticorpos Anticitoplasma de Neutrófilos/imunologia
Complemento C3a/metabolismo
Glomerulonefrite/patologia
Macrófagos/patologia
Peroxidase/imunologia
Receptores de Complemento/fisiologia
[Mh] Termos MeSH secundário: Animais
Formação de Anticorpos
Autoimunidade
Glomerulonefrite/imunologia
Imunidade Celular
Camundongos
Camundongos Endogâmicos C57BL
Receptores de Complemento/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Antineutrophil Cytoplasmic); 0 (Receptors, Complement); 80295-42-7 (Complement C3a); EC 1.11.1.7 (Peroxidase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190655


  6 / 22996 MEDLINE  
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[PMID]:29199037
[Au] Autor:Gao JR; Qin XJ; Jiang H; Gao YC; Guo MF; Jiang NN
[Ad] Endereço:Department of Pharmacy, The first affiliated hospital of Anhui university of Chinese medicine, 117 Meishan Road, Hefei, China. Electronic address: 1036951872@qq.com.
[Ti] Título:Potential role of lncRNAs in contributing to pathogenesis of chronic glomerulonephritis based on microarray data.
[So] Source:Gene;643:46-54, 2018 Feb 15.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Chronic glomerulonephritis (CGN) is the most common form of primary glomerular disease with unclear molecular mechanisms, which related to immune-mediated inflammatory diseases. Our study intended to identify potential long non-coding RNAs (lncRNAs) and genes, and to determine the potential molecular mechanisms of CGN pathogenesis. METHODS: The microarray of GSE64265 and GSE46295 were downloaded from the Gene Expression Omnibus database, GSE64265 including 3 rats control kidney tissues and 5 rats model kidney tissues, GSE46295 including 3 rats control kidney tissues and 3 rats model kidney tissues, which was on the basis of GPL1355 platform. Identification of differentially expressed lncRNAs and mRNAs were performed between the 2 groups. Gene ontology (GO) and pathway enrichment analyses were performed to analyze the biological functions and pathways for the differentially expressed mRNAs. LncRNA-mRNA weighted co-expression network was constructed using the WGCNA package to analyses for the genes in the modules. The protein-protein interaction (PPI) network was visualized. RESULTS: A total of 40 significantly up-regulated and 24 down-regulated lncRNAs, 653 up-regulated and 128 down-regulated mRNAs were identified. Additionally, Cdk1, with the highest connectivity degree in PPI network, was noteworthy enriched in cell cycle. Seven lncRNAs: NONRATT026650, LOC102547664, NONRATT77021989, NONRATT012453, LOC102551856, LOC102553536 and NONRATT7047175 were observed in the modules of lncRNA-mRNA weighted co-expression network. CONCLUSIONS: LncRNAs NONRATT026650, LOC102547664, NONRATT77021989, NONRATT012453, LOC102551856, LOC102553536 and NONRATT7047175 were differentially expressed and might play important roles in the development of CGN. Key genes, such as Cd44, Rftn1, Runx1, may be crucial biomarkers for CGN.
[Mh] Termos MeSH primário: Glomerulonefrite/genética
RNA Longo não Codificante/metabolismo
[Mh] Termos MeSH secundário: Animais
Biomarcadores
Bases de Dados de Ácidos Nucleicos
Perfilação da Expressão Gênica/métodos
Regulação Neoplásica da Expressão Gênica/genética
Ontologia Genética
Redes Reguladoras de Genes/genética
Glomerulonefrite/metabolismo
Glomerulonefrite/veterinária
Análise de Sequência com Séries de Oligonucleotídeos/métodos
RNA Longo não Codificante/genética
RNA Mensageiro/genética
Ratos
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (RNA, Long Noncoding); 0 (RNA, Messenger)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE


  7 / 22996 MEDLINE  
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[PMID]:29244911
[Au] Autor:Karzakova LM; Avtonomova OI; Kudryashov SI; Komelyagina NA; Ukhterova ND
[Ti] Título:The role of circulating cytokines and thyroid hormones in the development of the nephrotic variant of glomerulonephritis.
[So] Source:Patol Fiziol Eksp Ter;60(3):76-82, 2016 Jul-Sep.
[Is] ISSN:0031-2991
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:The purpose of the research - studying the features of the production of pro- and anti-inflammatory cytokines, as well as indicators of thyroid status in patients with nephrotic variant of glomerulonephritis (GN). Research methods. Methods: The examination involved 78 patients with primary GN, including 30 patients with nephrotic syndrome (NS) and 48 GN patients who had no NS symptoms. Laboratory researches included the determination of the concentration of the main cytokines circulating in the blood - IL-1b, IL-2, IL-4, IL-10, IFN-g and the receptor antagonist of IL-1b - Rа-IL-1b by the method of solid-phase enzyme linked immunosorbent assay enzyme immunoassay (ELISA) in the system of the bideterminant definition of antigen with the use of peroxidase as indicator enzyme using standard sets ("Cytokine", St.-Petersburg) according to the technique attached to a set. The investigation of the basic indicators of thyroid status - free thyroxine (FT4), free triiodothyronine (FT3), thyroid-stimulating hormone (TSH), anti-thyroid peroxydase antibodies (TPOAb) is carried out by the ELISA using standard sets and NGO techniques «Diagnostic systems¼ (N-Novgorod). The researches were conducted twice - before the hospitalization (1-2 days) and after the end of a stationary stage of treatment (12-14 days). Results: In 90% of patients with nephrotic option of GN there have been identified laboratory signs of hypothyroidism of different degrees of severity accompanied by increasing of production levels of proinflammatory cytokine IL-1b and IL-4, related to the activity of a humoral link of adaptive immunity. The reduction of glomerular, erythropoietic, concentration kidney functions, as well as proteinuria in patients with nephrotic option GN are associated with the decrease of T4 levels in the blood and increased levels of the cytokines circulating in the blood - IL-1b and IL-4. Conclusion: The obtained data demonstrate that the high level of production of IL-1b and IL-4 in GN patients causes hypothyroidism resulting in the formation of NS.
[Mh] Termos MeSH primário: Glomerulonefrite/sangue
Hipotireoidismo/sangue
Interleucina-10/sangue
Interleucina-4/sangue
Síndrome Nefrótica/sangue
Complicações na Gravidez/sangue
Hormônios Tireóideos/sangue
[Mh] Termos MeSH secundário: Feminino
Glomerulonefrite/complicações
Seres Humanos
Hipotireoidismo/complicações
Masculino
Síndrome Nefrótica/complicações
Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (IL10 protein, human); 0 (IL4 protein, human); 0 (Thyroid Hormones); 130068-27-8 (Interleukin-10); 207137-56-2 (Interleukin-4)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE


  8 / 22996 MEDLINE  
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[PMID]:28450461
[Au] Autor:Chen TD; Rotival M; Chiu LY; Bagnati M; Ko JH; Srivastava PK; Petretto E; Pusey CD; Lai PC; Aitman TJ; Cook HT; Behmoaras J
[Ad] Endereço:Centre for Complement and Inflammation Research, Imperial College London, London W12 0NN, United Kingdom.
[Ti] Título:Identification of Ceruloplasmin as a Gene that Affects Susceptibility to Glomerulonephritis Through Macrophage Function.
[So] Source:Genetics;206(2):1139-1151, 2017 06.
[Is] ISSN:1943-2631
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Crescentic glomerulonephritis (Crgn) is a complex disorder where macrophage activity and infiltration are significant effector causes. In previous linkage studies using the uniquely susceptible Wistar Kyoto (WKY) rat strain, we have identified multiple crescentic glomerulonephritis QTL ( ) and positionally cloned genes underlying and , which accounted for 40% of total variance in glomerular inflammation. Here, we have generated a backcross (BC) population ( = 166) where and were genetically fixed and found significant linkage to glomerular crescents on chromosome 2 ( , LOD = 3.8). Fine mapping analysis by integration with genome-wide expression QTLs (eQTLs) from the same BC population identified ceruloplasmin ( ) as a positional eQTL in macrophages but not in serum. Liquid chromatography-tandem mass spectrometry confirmed Cp as a protein QTL in rat macrophages. WKY macrophages overexpress Cp and its downregulation by RNA interference decreases markers of glomerular proinflammatory macrophage activation. Similarly, short incubation with Cp results in a strain-dependent macrophage polarization in the rat. These results suggest that genetically determined Cp levels can alter susceptibility to Crgn through macrophage function and propose a new role for Cp in early macrophage activation.
[Mh] Termos MeSH primário: Ceruloplasmina/genética
Predisposição Genética para Doença
Glomerulonefrite/genética
[Mh] Termos MeSH secundário: Animais
Ceruloplasmina/biossíntese
Mapeamento Cromossômico
Regulação da Expressão Gênica
Ligação Genética
Glomerulonefrite/patologia
Seres Humanos
Macrófagos/metabolismo
Macrófagos/patologia
Ratos
Ratos Endogâmicos WKY
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
EC 1.16.3.1 (Ceruloplasmin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1534/genetics.116.197376


  9 / 22996 MEDLINE  
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[PMID]:27772637
[Au] Autor:Fogo AB; Lusco MA; Najafian B; Alpers CE
[Ad] Endereço:Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN. Electronic address: agnes.fogo@vanderbilt.edu.
[Ti] Título:AJKD Atlas of Renal Pathology: Pauci-immune Necrotizing Crescentic Glomerulonephritis.
[So] Source:Am J Kidney Dis;68(5):e31-e32, 2016 Nov.
[Is] ISSN:1523-6838
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Vasculite Associada a Anticorpo Anticitoplasma de Neutrófilos/patologia
Glomerulonefrite/patologia
Rim/patologia
[Mh] Termos MeSH secundário: Vasculite Associada a Anticorpo Anticitoplasma de Neutrófilos/metabolismo
Membrana Basal Glomerular/metabolismo
Membrana Basal Glomerular/patologia
Membrana Basal Glomerular/ultraestrutura
Glomerulonefrite/metabolismo
Granuloma/patologia
Seres Humanos
Rim/metabolismo
Rim/ultraestrutura
Túbulos Renais/metabolismo
Túbulos Renais/patologia
Túbulos Renais/ultraestrutura
Microscopia
Microscopia Eletrônica
Microscopia de Fluorescência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171205
[Lr] Data última revisão:
171205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  10 / 22996 MEDLINE  
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[PMID]:28745696
[Au] Autor:Kutyrina IM
[Ad] Endereço:I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.
[Ti] Título:[Obesity-related glomerulopathy: Mechanisms of development, clinical course].
[Ti] Título:Glomerulopatiia, assotsiirovannaia s ozhireniem: mekhanizmy razvitiia, klinicheskoe techenie..
[So] Source:Ter Arkh;89(6):97-101, 2017.
[Is] ISSN:0040-3660
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Obesity and overweight are recognized as epidemics of non-communicable diseases in the 21st century. The kidneys are a target organ for obesity, damage to which is considered to be an independent risk factor for the development of renal failure. Obesity-related glomerulopathy (OGP) is one of the types of renal injury in obesity, which is characterized by the development of proteinuria in patients with a body mass index (BMI) of >30 kg/m2 in the absence of other causes of kidney damage. The pathogenesis of OGP is multifactorial. It is associated with intrarenal hemodynamic disorders - the development of renal hyperfiltration, the damaging action of adipose tissue hormones (hyperleptinemia, activation of the renin-angiotensin-aldosterone system, decreased production of adiponectin); with ectopic lipid accumulation in the kidney. The morphological pattern of OGP is characterized by a low glomerular density (oligonephronia) that leads to glomerular and tubular hypertrophy; by the development of perihilar focal segmental glomerulosclerosis (FSGS), obvious podocyte damages, and the development of a fatty kidney. The clinical picture of OGP is characterized by the slow and gradual development of albuminuria, not exceeding Stage A3 (300-1999 mg/day). Approximately one-third of patients develop partial nephrotic syndrome with massive proteinuria, but without edema and hypoproteinemia. Complete nephrotic syndrome is observed in not more than 6% of patients with OGP. In the course of the disease, 50% of patients develop hypertension and more than 80% do dyslipidemia. Stages IV-V chronic kidney disease may develop 20-30 years after the disease occurs.
[Mh] Termos MeSH primário: Progressão da Doença
Glomerulonefrite/etiologia
Obesidade/complicações
[Mh] Termos MeSH secundário: Glomerulonefrite/complicações
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171129
[Lr] Data última revisão:
171129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.17116/terarkh201789697-101



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