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Pesquisa : C12.777.419.570.643.150 [Categoria DeCS]
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[PMID]:28146082
[Au] Autor:Jadot I; Declèves AE; Nortier J; Caron N
[Ad] Endereço:Molecular Physiology Research Unit-URPhyM, Namur Research Institute for Life Sciences (NARILIS), University of Namur (UNamur), Namur 5000, Belgium. ines.jadot@unamur.be.
[Ti] Título:An Integrated View of Aristolochic Acid Nephropathy: Update of the Literature.
[So] Source:Int J Mol Sci;18(2), 2017 Jan 29.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The term "aristolochic acid nephropathy" (AAN) is used to include any form of toxic interstitial nephropathy that is caused either by ingestion of plants containing aristolochic acids (AA) as part of traditional phytotherapies (formerly known as "Chinese herbs nephropathy"), or by the environmental contaminants in food (Balkan endemic nephropathy). It is frequently associated with urothelial malignancies. Although products containing AA have been banned in most of countries, AAN cases remain regularly reported all over the world. Moreover, AAN incidence is probably highly underestimated given the presence of AA in traditional herbal remedies worldwide and the weak awareness of the disease. During these two past decades, animal models for AAN have been developed to investigate underlying molecular and cellular mechanisms involved in AAN pathogenesis. Indeed, a more-in-depth understanding of these processes is essential to develop therapeutic strategies aimed to reduce the global and underestimated burden of this disease. In this regard, our purpose was to build a broad overview of what is currently known about AAN. To achieve this goal, we aimed to summarize the latest data available about underlying pathophysiological mechanisms leading to AAN development with a particular emphasis on the imbalance between vasoactive factors as well as a focus on the vascular events often not considered in AAN.
[Mh] Termos MeSH primário: Ácidos Aristolóquicos/efeitos adversos
Medicamentos de Ervas Chinesas/efeitos adversos
Nefrite Intersticial/etiologia
[Mh] Termos MeSH secundário: Animais
Ácidos Aristolóquicos/química
Ácidos Aristolóquicos/metabolismo
Nefropatia dos Bálcãs/diagnóstico
Nefropatia dos Bálcãs/epidemiologia
Nefropatia dos Bálcãs/etiologia
Biópsia
Transformação Celular Neoplásica/induzido quimicamente
Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/metabolismo
Fibrose
Seres Humanos
Neoplasias Renais/etiologia
Nefrite Intersticial/diagnóstico
Nefrite Intersticial/epidemiologia
Estresse Oxidativo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Aristolochic Acids); 0 (Drugs, Chinese Herbal)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170420
[Lr] Data última revisão:
170420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170202
[St] Status:MEDLINE


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[PMID]:27871899
[Au] Autor:Stoev SD
[Ad] Endereço:Department of General and Clinical Pathology, Faculty of Veterinary Medicine, Trakia University, Students Campus, 6000 Stara Zagora, Bulgaria. Electronic address: s_stoev@hotmail.com.
[Ti] Título:Balkan Endemic Nephropathy - Still continuing enigma, risk assessment and underestimated hazard of joint mycotoxin exposure of animals or humans.
[So] Source:Chem Biol Interact;261:63-79, 2017 Jan 05.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:The spreading of mycotoxic nephropathy in animals/humans was studied. The possible etiological causes provoking this nephropathy were carefully reviewed and analyzed. The natural content of the most frequent nephrotoxic mycotoxins in target feedstuffs/foods were investigated, in addition to their significance for development of renal damages in endemic areas. An estimation of the level of exposure of humans to the nephrotoxic mycotoxin, ochratoxin A (OTA), is made. The possible synergism or additive effects between some target mycotoxins in the development of nephropathy is also covered. The significance of joint mycotoxin interaction and masked mycotoxins, in addition to some newly isolated fungal toxic agents in the complicated etiology of mycotoxic nephropathy ranged in Balkan countries is discussed. The importance of some target fungal species which can induce kidney damages was evaluated. The morphological/ultrastructural, functional and toxicological similarities between human and animal nephropathy are studied. The possible hazard of low content of combinations of some target mycotoxins in food or feedstuff ingested by pigs, chickens or humans under natural conditions is evaluated and a risk assessment was made. Some different but more effective manners of prophylaxis and/or prevention against OTA contamination of feedstuffs/foods are suggested. A survey was made in regard to the best possible ways of veterinary hygiene control of OTA-exposed animals at slaughter time for preventing the entrance of OTA in commercial feedstuffs/food channels with a view to reduce the possible health hazard for humans. The economic efficacy and applicability of such preventive measures is additionally discussed and some practical suggestions are made.
[Mh] Termos MeSH primário: Nefropatia dos Bálcãs/epidemiologia
Doenças Endêmicas
Micotoxinas/toxicidade
Medição de Risco
[Mh] Termos MeSH secundário: Animais
Península Balcânica
Seres Humanos
Modelos Biológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Mycotoxins)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170207
[Lr] Data última revisão:
170207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161123
[St] Status:MEDLINE


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[PMID]:27568660
[Au] Autor:Matic M; Dragicevic B; Pekmezovic T; Suvakov S; Savic-Radojevic A; Pljesa-Ercegovac M; Dragicevic D; Smiljic J; Simic T
[Ad] Endereço:Institute of Medical and Clinical Biochemistry.
[Ti] Título:Common Polymorphisms in GSTA1, GSTM1 and GSTT1 Are Associated with Susceptibility to Urinary Bladder Cancer in Individuals from Balkan Endemic Nephropathy Areas of Serbia.
[So] Source:Tohoku J Exp Med;240(1):25-30, 2016 09.
[Is] ISSN:1349-3329
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Balkan endemic nephropathy (BEN) is a chronic familial form of interstitial nephritis that might eventually lead to end stage renal disease. This nephropathy affects individuals living along of the Danube River and its tributaries in Serbia, Bosnia, Croatia, Bulgaria and Romania. The increased incidence of urinary tract tumors in the BEN areas is well described, but its specific genetic predisposition is still unclear. Certain nephrocarcinogenic compounds, including those associated with BEN, are metabolized by glutathione S-transferase (GST) superfamily of phase II detoxication enzymes. Importantly, the GST-mediated detoxification may result in formation of more toxic compounds. We examined the association of common GST polymorphisms and bladder cancer (BC) risk in individuals from BEN areas in Serbia. A hospital-based case-control study included 201 BC cases (67 from BEN region) and 122 controls. Each polymorphism was identified by a PCR-based method. Individuals from BEN region with low-expression GSTA1 genotype (AB+BB) exhibited a 2.6-fold higher BC risk compared to those with GSTA1 (AA) genotype who were from non-BEN region (OR = 2.60, p = 0.015). In contrast, carriers of GSTM1-active genotype from BEN region had a 2.9-fold increased BC risk compared to those with GSTM1-active genotype from non-BEN region (OR = 2.90, p = 0.010). Likewise, carriers with GSTT1-active genotype from BEN region exhibited 2.1-fold higher BC risk compared to those from non-BEN region with GSTT1-active genotype (OR = 2.10, p = 0.027). Thus, common polymorphisms in GSTA1, GSTM1 and GSTT1 are associated with susceptibility to BC in individuals from BEN areas of Serbia.
[Mh] Termos MeSH primário: Nefropatia dos Bálcãs/genética
Predisposição Genética para Doença
Glutationa Transferase/genética
Polimorfismo Genético
Neoplasias da Bexiga Urinária/enzimologia
Neoplasias da Bexiga Urinária/genética
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Demografia
Feminino
Seres Humanos
Masculino
Meia-Idade
Fatores de Risco
Sérvia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.5.1.- (glutathione S-transferase T1); EC 2.5.1.18 (GSTA1 protein, human); EC 2.5.1.18 (Glutathione Transferase); EC 2.5.1.18 (glutathione S-transferase M1)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160830
[St] Status:MEDLINE
[do] DOI:10.1620/tjem.240.25


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[PMID]:27538407
[Au] Autor:Stiborová M; Arlt VM; Schmeiser HH
[Ad] Endereço:Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, 128 40, Prague 2, Czech Republic. stiborov@natur.cuni.cz.
[Ti] Título:Balkan endemic nephropathy: an update on its aetiology.
[So] Source:Arch Toxicol;90(11):2595-2615, 2016 Nov.
[Is] ISSN:1432-0738
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Balkan endemic nephropathy (BEN) is a unique, chronic renal disease frequently associated with upper urothelial cancer (UUC). It only affects residents of specific farming villages located along tributaries of the Danube River in Bosnia-Herzegovina, Croatia, Macedonia, Serbia, Bulgaria, and Romania where it is estimated that ~100,000 individuals are at risk of BEN, while ~25,000 have the disease. This review summarises current findings on the aetiology of BEN. Over the last 50 years, several hypotheses on the cause of BEN have been formulated, including mycotoxins, heavy metals, viruses, and trace-element insufficiencies. However, recent molecular epidemiological studies provide a strong case that chronic dietary exposure to aristolochic acid (AA) a principal component of Aristolochia clematitis which grows as a weed in the wheat fields of the endemic regions is the cause of BEN and associated UUC. One of the still enigmatic features of BEN that need to be resolved is why the prevalence of BEN is only 3-7 %. This suggests that individual genetic susceptibilities to AA exist in humans. In fact dietary ingestion of AA along with individual genetic susceptibility provides a scenario that plausibly can explain all the peculiarities of BEN such as geographical distribution and high risk of urothelial cancer. For the countries harbouring BEN implementing public health measures to avoid AA exposure is of the utmost importance because this seems to be the best way to eradicate this once mysterious disease to which the residents of BEN villages have been completely and utterly at mercy for so long.
[Mh] Termos MeSH primário: Ácidos Aristolóquicos/toxicidade
Nefropatia dos Bálcãs/induzido quimicamente
Carcinógenos Ambientais/toxicidade
Doenças Endêmicas
Medicina Baseada em Evidências
Contaminação de Alimentos
Rim/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Aristolochia/química
Aristolochia/crescimento & desenvolvimento
Aristolochia/toxicidade
Ácidos Aristolóquicos/análise
Nefropatia dos Bálcãs/epidemiologia
Nefropatia dos Bálcãs/fisiopatologia
Nefropatia dos Bálcãs/prevenção & controle
Carcinógenos Ambientais/análise
Fatores de Confusão (Epidemiologia)
Produtos Agrícolas/crescimento & desenvolvimento
Dieta/efeitos adversos
Resistência a Medicamentos
Europa Oriental/epidemiologia
Farinha/efeitos adversos
Farinha/análise
Contaminação de Alimentos/prevenção & controle
Seres Humanos
Rim/fisiopatologia
Plantas Daninhas/química
Plantas Daninhas/crescimento & desenvolvimento
Plantas Daninhas/toxicidade
Prevalência
Risco
Sementes/crescimento & desenvolvimento
Triticum/crescimento & desenvolvimento
Neoplasias Urológicas/induzido quimicamente
Neoplasias Urológicas/epidemiologia
Neoplasias Urológicas/fisiopatologia
Neoplasias Urológicas/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Aristolochic Acids); 0 (Carcinogens, Environmental); 94218WFP5T (aristolochic acid I)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160820
[St] Status:MEDLINE


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[PMID]:27362729
[Au] Autor:Chan W; Pavlovic NM; Li W; Chan CK; Liu J; Deng K; Wang Y; Milosavljevic B; Kostic EN
[Ti] Título:Quantitation of Aristolochic Acids in Corn, Wheat Grain, and Soil Samples Collected in Serbia: Identifying a Novel Exposure Pathway in the Etiology of Balkan Endemic Nephropathy.
[So] Source:J Agric Food Chem;64(29):5928-34, 2016 Jul 27.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:While to date investigations provided convincing evidence on the role of aristolochic acids (AAs) in the etiology of Balkan endemic nephropathy (BEN) and upper urothelial cancer (UUC), the exposure pathways by which AAs enter human bodies to cause BEN and UUC remain obscure. The goal of this study is to test the hypothesis that environmental pollution by AAs and root uptake of AAs in the polluted soil may be one of the pathways by which AAs enter the human food chain. The hypothesis driving this study was that the decay of Aristolochia clematitis L., a AA-containing herbaceous plant that is found growing widespread in the endemic regions, could release free AAs to the soil, which could be taken up by food crops growing nearby, thereby transferring this potent human nephrotoxin and carcinogen into their edible parts. Using the highly sensitive and selective high-performance liquid chromatography coupled with fluorescence detection method, we identified and quantitated in this study for the first time AAs in corn, wheat grain, and soil samples collected from the endemic village Kutles in Serbia. Our results provide the first direct evidence that food crops and soil in the Balkans are contaminated with AAs. It is possible that the presence of AAs in edible parts of crops originating from the AA-contaminated soil could be one of the major pathways by which humans become exposed to AAs.
[Mh] Termos MeSH primário: Aristolochia/química
Ácidos Aristolóquicos/análise
Nefropatia dos Bálcãs/etiologia
Poluentes do Solo/análise
Triticum/química
Zea mays/química
[Mh] Termos MeSH secundário: Ácidos Aristolóquicos/toxicidade
Nefropatia dos Bálcãs/epidemiologia
Exposição Ambiental/análise
Seres Humanos
Sérvia/epidemiologia
Solo/química
Poluentes do Solo/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aristolochic Acids); 0 (Soil); 0 (Soil Pollutants)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160701
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.6b02203


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[PMID]:27228168
[Au] Autor:Reed AP; Bucci G; Abd-Wahab F; Tucker SJ
[Ad] Endereço:Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, United Kingdom.
[Ti] Título:Dominant-Negative Effect of a Missense Variant in the TASK-2 (KCNK5) K+ Channel Associated with Balkan Endemic Nephropathy.
[So] Source:PLoS One;11(5):e0156456, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:TASK-2, a member of the Two-Pore Domain (K2P) subfamily of K+ channels, is encoded by the KCNK5 gene. The channel is expressed primarily in renal epithelial tissues and a potentially deleterious missense variant in KCNK5 has recently been shown to be prevalent amongst patients predisposed to the development of Balkan Endemic Nephropathy (BEN), a chronic tubulointerstitial renal disease of unknown etiology. In this study we show that this variant (T108P) results in a complete loss of channel function and is associated with a major reduction in TASK-2 channel subunits at the cell surface. Furthermore, these mutant subunits have a suppressive or 'dominant-negative' effect on channel function when coexpressed with wild-type subunits. This missense variant is located at the extracellular surface of the M2 transmembrane helix and by using a combination of structural modelling and further functional analysis we also show that this highly-conserved threonine residue is critical for the correct function of other K2P channels. These results therefore provide further structural and functional insights into the possible pathophysiological effects of this missense variant in TASK-2.
[Mh] Termos MeSH primário: Nefropatia dos Bálcãs/metabolismo
Mutação de Sentido Incorreto
Canais de Potássio de Domínios Poros em Tandem/química
Canais de Potássio de Domínios Poros em Tandem/metabolismo
[Mh] Termos MeSH secundário: Substituição de Aminoácidos
Animais
Nefropatia dos Bálcãs/genética
Seres Humanos
Oócitos/metabolismo
Canais de Potássio de Domínios Poros em Tandem/genética
Domínios Proteicos
Estrutura Secundária de Proteína
Relação Estrutura-Atividade
Xenopus laevis
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (KCNK5 protein, human); 0 (Potassium Channels, Tandem Pore Domain)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160527
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0156456


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[PMID]:27218105
[Au] Autor:Popovska-Jankovic K; Noveski P; Jankovic-Velickovic L; Stojnev S; Cukuranovic R; Stefanovic V; Toncheva D; Staneva R; Polenakovic M; Plaseska-Karanfilska D
[Ad] Endereço:Research Centre for Genetic Engineering and Biotechnology "Georgi D. Efremov", Macedonian Academy of Sciences and Arts, 1000 Skopje, Macedonia.
[Ti] Título:MicroRNA Profiling in Patients with Upper Tract Urothelial Carcinoma Associated with Balkan Endemic Nephropathy.
[So] Source:Biomed Res Int;2016:7450461, 2016.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Balkan endemic nephropathy (BEN) is a disease that affects people that live in the alluvial plains along the tributaries of the Danube River in the Balkan region. BEN is a chronic tubulointerstitial disease with a slow progression to terminal renal failure and has strong association with upper tract urothelial carcinoma (UTUC). There are several hypotheses about the etiology of BEN, but only the toxic effect of aristolochic acid has been confirmed as a risk factor in the occurrence of the disease. Aberrantly expressed miRNAs have been shown to be associated with many types of cancers. A number of studies have investigated the expression of microRNAs in urothelial carcinoma, mainly on urothelial bladder cancer, and only a few have included patients with UTUC. Here we present the first study of microRNA profiling in UTUC tissues from patients with BEN (BEN-UTUC) and patients with UTUC from nonendemic Balkan regions (non-BEN-UTUC) in comparison to normal kidney tissues. We found 10 miRNAs that were differentially expressed in patients with BEN-UTUC and 15 miRNAs in patients with non-BEN-UTUC. miRNA signature determined in BEN-UTUC patients differs from the non-BEN-UTUC patients; only miR-205-5p was mutual in both groups.
[Mh] Termos MeSH primário: Nefropatia dos Bálcãs/metabolismo
Biomarcadores Tumorais/metabolismo
Carcinoma de Células de Transição/metabolismo
MicroRNAs/metabolismo
Neoplasias Ureterais/metabolismo
[Mh] Termos MeSH secundário: Adulto
Idoso
Nefropatia dos Bálcãs/epidemiologia
Península Balcânica/epidemiologia
Carcinoma de Células de Transição/epidemiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Neoplasias Ureterais/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (MicroRNAs)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160525
[St] Status:MEDLINE
[do] DOI:10.1155/2016/7450461


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[PMID]:26914156
[Au] Autor:Veale EL; Mathie A
[Ad] Endereço:Medway School of Pharmacy, University of Kent, Kent, UK.
[Ti] Título:Aristolochic acid, a plant extract used in the treatment of pain and linked to Balkan endemic nephropathy, is a regulator of K2P channels.
[So] Source:Br J Pharmacol;173(10):1639-52, 2016 May.
[Is] ISSN:1476-5381
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: Aristolochic acid (AristA) is found in plants used in traditional medicines to treat pain. We investigated the action of AristA on TREK and TRESK, potassium (K2P) channels, which are potential therapeutic targets in pain. Balkan endemic nephropathy (BEN) is a renal disease associated with AristA consumption. A mutation of TASK-2 (K2P 5.1) channels (T108P) is seen in some patients susceptible to BEN, so we investigated how both this mutation and AristA affected TASK-2 channels. EXPERIMENTAL APPROACH: Currents through wild-type and mutated human K2P channels expressed in tsA201 cells were measured using whole-cell patch-clamp recordings in the presence and absence of AristA. KEY RESULTS: TREK-1- and TREK-2-mediated currents were enhanced by AristA (100 µM), whereas TRESK was inhibited. Inhibition of TRESK did not depend on the phosphorylation of key intracellular serines but was completely blocked by mutation of bulky residues in the inner pore (F145A_F352A). The TASK-2_T108P mutation markedly reduced both current density and ion selectivity. A related mutation (T108C) had similar but less marked effects. External alkalization and application of flufenamic acid enhanced TASK-2 and TASK-2_T108C current but did not affect TASK-2_T108P current. AristA (300 µM) produced a modest enhancement of TASK-2 current. CONCLUSIONS AND IMPLICATIONS: Enhancement of TREK-1 and TREK-2 and inhibition of TRESK by AristA may contribute to therapeutically useful effects of this compound in pain. Whilst AristA is unlikely to interact directly with TASK-2 channels in BEN, loss of functional TASK-2 channels may indirectly increase susceptibility to AristA toxicity.
[Mh] Termos MeSH primário: Ácidos Aristolóquicos/farmacologia
Nefropatia dos Bálcãs/tratamento farmacológico
Dor/tratamento farmacológico
Extratos Vegetais/química
Canais de Potássio de Domínios Poros em Tandem/antagonistas & inibidores
[Mh] Termos MeSH secundário: Ácidos Aristolóquicos/química
Ácidos Aristolóquicos/isolamento & purificação
Células Cultivadas
Relação Dose-Resposta a Droga
Seres Humanos
Estrutura Molecular
Canais de Potássio de Domínios Poros em Tandem/genética
Canais de Potássio de Domínios Poros em Tandem/metabolismo
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aristolochic Acids); 0 (Plant Extracts); 0 (Potassium Channels, Tandem Pore Domain); 94218WFP5T (aristolochic acid I)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160226
[St] Status:MEDLINE
[do] DOI:10.1111/bph.13465


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[PMID]:26725075
[Au] Autor:Pavlovic D; Savic-Radojevic A; Pljesa-Ercegovac M; Radic T; Ristic S; Coric V; Matic M; Simic T; Djukanovic L
[Ad] Endereço:University Hospital Foca, Foca, Bosnia and Herzegovina.
[Ti] Título:Biomarkers of oxidative damage and antioxidant enzyme activities in pre-dialysis Balkan endemic nephropathy patients.
[So] Source:Int Urol Nephrol;48(2):257-63, 2016 Feb.
[Is] ISSN:1573-2584
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIM: To obtain more insight into molecular mechanisms underlying oxidative stress in Balkan endemic nephropathy (BEN), biomarkers of oxidative stress and antioxidant enzyme activities were studied in 38 pre-dialysis BEN patients, 21 healthy BEN family members and 36 healthy subjects from non-endemic areas. METHODS: Protein thiol groups (P-SH), antioxidant enzyme activities [superoxide dismutase (SOD) and glutathione peroxidase (GPX)], were determined in plasma spectrophotometrically, while malondialdehyde adducts (MDA) by enzyme immunoassay. RESULTS: BEN patients had significantly lower plasma GPX activity in comparison with values for both control groups (p = 0.016), gradually decreasing with kidney function impairment estimated by glomerular filtration rate (r = 0.53, p = 0.002). GPX activity was inversely correlated with serum urea (r = -0.627, p < 0.001), creatinine (r = -0.53, p < 0.05), urinary excretion of protein and α1-microglobulin (r = -0.44, p = 0.012; r = -0.50, p < 0.007). Significant upregulation of SOD activity was observed in healthy BEN family members (p < 0.05). While the concentration of MDA adducts was similar in all three groups, BEN patients and healthy BEN family members exhibited increased protein damage, based on fewer P-SH groups in comparison with subjects from non-BEN areas (p = 0.085; p = 0.014, respectively). CONCLUSIONS: Based on our results on increased oxidative protein damage in both pre-dialysis BEN patients and healthy BEN family members, it can be speculated that individuals from BEN areas, in general, are chronically exposed to some prooxidant environmental compounds. Moreover, decrease in plasma GPX activity, as a consequence of impaired kidney function, could further affect oxidative status in BEN patients.
[Mh] Termos MeSH primário: Nefropatia dos Bálcãs/enzimologia
Biomarcadores/metabolismo
Taxa de Filtração Glomerular/fisiologia
Glutationa Peroxidase/metabolismo
Estresse Oxidativo/fisiologia
Diálise Renal
Superóxido Dismutase/metabolismo
[Mh] Termos MeSH secundário: Adulto
Nefropatia dos Bálcãs/fisiopatologia
Nefropatia dos Bálcãs/terapia
Ensaio de Imunoadsorção Enzimática
Feminino
Seres Humanos
Masculino
Meia-Idade
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160104
[St] Status:MEDLINE
[do] DOI:10.1007/s11255-015-1192-9


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[PMID]:26654710
[Au] Autor:Li W; Hu Q; Chan W
[Ad] Endereço:Department of Chemistry, The Hong Kong University of Science and Technology , Clear Water Bay, Kowloon, Hong Kong SAR, China.
[Ti] Título:Uptake and Accumulation of Nephrotoxic and Carcinogenic Aristolochic Acids in Food Crops Grown in Aristolochia clematitis-Contaminated Soil and Water.
[So] Source:J Agric Food Chem;64(1):107-12, 2016 Jan 13.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Emerging evidence has suggested aristolochic acids (AAs) are linked to the development of Balkan endemic nephropathy (BEN), a chronic renal disease affecting numerous farmers living in the Balkan peninsula. However, the pathway by which AAs enter the human food chain and cause kidney disease remains poorly understood. Using our previously developed analytical method with high sensitivity and selectivity (Chan, W.; Lee, K. C.; Liu, N.; Cai, Z. J. Chromatogr. A 2007, 1164, 113-119), we quantified AAs in lettuce, tomato, and spring onion grown in AA-contaminated soil and culture medium. Our study revealed that AAs were being taken up from the soil and bioaccumulated in food crops in a time- and dose-dependent manner. To the best of our knowledge, this study is the first to identify one of the possible pathways by which AAs enter our food chain to cause chronic food poisoning. Results also demonstrated that AAs were resistant to the microbial activity of the soil/water.
[Mh] Termos MeSH primário: Aristolochia/toxicidade
Ácidos Aristolóquicos/toxicidade
Nefropatia dos Bálcãs/etiologia
Carcinógenos/metabolismo
Produtos Agrícolas/metabolismo
Poluentes do Solo/metabolismo
Poluentes Químicos da Água/metabolismo
[Mh] Termos MeSH secundário: Aristolochia/química
Ácidos Aristolóquicos/análise
Ácidos Aristolóquicos/metabolismo
Nefropatia dos Bálcãs/metabolismo
Carcinógenos/análise
Carcinógenos/toxicidade
Produtos Agrícolas/química
Produtos Agrícolas/crescimento & desenvolvimento
Seres Humanos
Poluentes do Solo/análise
Poluentes do Solo/toxicidade
Poluentes Químicos da Água/análise
Poluentes Químicos da Água/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Aristolochic Acids); 0 (Carcinogens); 0 (Soil Pollutants); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160113
[Lr] Data última revisão:
160113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151215
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.5b05089



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